Search:
Tokushima University > Graduate School of Biomedical Sciences > 医学域 > Medical Science > Pathological Sciences > Department of Immunology and Parasitology >
Tokushima University > Faculty of Medicine > School of Medicine > Course of Microbiology and Immunology > Immunology and Parasitology >
Tokushima University > Graduate School of Medical Sciences > Medical Science > Course of Microbiology and Immunology >
(CSV files for researchmap) [PDF manual]

Research Activity

Field of Study

Immunology

Subject of Study

Notchシグナルによる免疫担当細胞の分化・機能制御

Book / Paper

Book:

1. Chieko Ishifune and Koji Yasutomo :
Notch and Myeloid Cells,
Springer, 2017.

Academic Paper (Judged Full Paper):

1. Chieko Ishifune, Shin-ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Hyun Doo Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano and Koji Yasutomo :
Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.,
PLoS Biology, Vol.17, No.5, 2019.
(DOI: 10.1371/journal.pbio.3000262,   PubMed: 31071093)
2. Masanori Niki, Kohhei Nakajima, Daichi Ishikawa, Jun Nishida, Chieko Ishifune, Shin-ichi Tsukumo, Mitsuo Shimada, Shinji Nagahiro, Yoshinori Mitamura and Koji Yasutomo :
MicroRNA-449a deficiency promotes colon carcinogenesis.,
Scientific Reports, Vol.7, No.1, 10696, 2017.
(Tokushima University Institutional Repository: 112383,   DOI: 10.1038/s41598-017-10500-0,   PubMed: 28878284,   Elsevier: Scopus)
3. Sultana Taskia Zaman, Hideki Arimochi, Satoshi Maruyama, Chieko Ishifune, Shin-ichi Tsukumo, Akiko Kitamura and Koji Yasutomo :
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression.,
The Journal of Immunology, Vol.199, No.6, 1989-1997, 2017.
(DOI: 10.4049/jimmunol.1700645,   PubMed: 28779023)
4. Takahiro Furukawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Yoichi Maekawa, Naoko Matsui, Ryuji Kaji and Koji Yasutomo :
Transmission of survival signals through Delta-like 1 on activated CD4(+) T cells.,
Scientific Reports, Vol.6, 33692, 2016.
(Tokushima University Institutional Repository: 112325,   DOI: 10.1038/srep33692,   PubMed: 27659682,   Elsevier: Scopus)
5. Jaba Gamrekelashvili, Roberto Giagnorio, Jasmin Jussofie, Oliver Soehnlein, Johan Duchene, G Carlos Briseño, K Saravana Ramasamy, Kashyap Krishnasamy, Anne Limbourg, Tamar Kapanadze, Chieko Ishifune, Rabea Hinkel, Freddy Radtke, J Lothar Strobl, Ursula Zimber-Strobl, Christian L Napp, Johann Bauersachs, Hermann Haller, Koji Yasutomo, Christian Kupatt, M Kenneth Murphy, H Ralf Adams, Christian Weber and P Florian Limbourg :
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.,
Nature Communications, Vol.7, 12597, 2016.
(Tokushima University Institutional Repository: 112441,   DOI: 10.1038/ncomms12597,   PubMed: 27576369,   Elsevier: Scopus)
6. SJ Oh, S Ahn, YH Jin, Chieko Ishifune, JH Kim, Koji Yasutomo and DH Chung :
Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells.,
Journal of Leukocyte Biology, Vol.98, No.5, 781-789, 2015.
(DOI: 10.1189/jlb.1A0914-459RR,   PubMed: 26188077,   Elsevier: Scopus)
7. Kurihara Takeshi, Hideki Arimochi, Bhuyan Ahmed Zaied, Chieko Ishifune, Tsumura Hideki, Ito Morihiro, Ito Yasuhiko, Akiko Kitamura, Yoichi Maekawa and Koji Yasutomo :
CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon- Production In Vivo,
PLoS ONE, Vol.10, No.10, e0139692, 2015.
(DOI: 10.1371/journal.pone.0139692,   PubMed: 26444422)
8. Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita and Koji Yasutomo :
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.,
Nature Medicine, Vol.21, No.1, 55-61, 2015.
(DOI: 10.1038/nm.3758,   PubMed: 25501905,   Elsevier: Scopus)
9. Chieko Ishifune, Satoshi Maruyama, Yuki Sasaki, Hideo Yagita, Katsuto Hozumi, Taisuke Tomita, Kenji Kishihara and Koji Yasutomo :
Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.111, No.16, 5986-5991, 2014.
(DOI: 10.1073/pnas.1401671111,   PubMed: 24711412)
10. Ahmed Zaied Bhuyan, Michihito Asanoma, Akiko Iwata, Chieko Ishifune, Yoichi Maekawa, Mitsuo Shimada and Koji Yasutomo :
Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells.,
PLoS ONE, Vol.9, No.2, e89266, 2014.
(DOI: 10.1371/journal.pone.0089266,   PubMed: 24586644)
11. Ahmed Zaied Bhuyan, Hideki Arimochi, Jun Nishida, Keiko Kataoka, Takeshi Kurihara, Chieko Ishifune, Hideki Tsumura, Morihiro Ito, Yasuhiko Ito, Akiko Kitamura and Koji Yasutomo :
CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells.,
Biochemical and Biophysical Research Communications, Vol.444, No.4, 628-633, 2014.
(DOI: 10.1016/j.bbrc.2014.01.144,   PubMed: 24491544,   Elsevier: Scopus)
12. Kohhei Nakajima, Yoichi Maekawa, Keiko Kataoka, Chieko Ishifune, Jun Nishida, Hideki Arimochi, Akiko Kitamura, Takayuki Yoshimoto, Shuhei Tomita, Shinji Nagahiro and Koji Yasutomo :
The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+cells.,
Nature Communications, Vol.4, 2112, 2013.
(DOI: 10.1038/ncomms3112,   PubMed: 23836150,   Elsevier: Scopus)
13. Shuichi Iwahashi, Yoichi Maekawa, Jun Nishida, Chieko Ishifune, Akiko Kitamura, Hideki Arimochi, Keiko Kataoka, Shigeru Chiba, Mitsuo Shimada and Koji Yasutomo :
Notch2 regulates the development of marginal zone B cells through Fos.,
Biochemical and Biophysical Research Communications, Vol.418, No.4, 701-707, 2012.
(DOI: 10.1016/j.bbrc.2012.01.082,   PubMed: 22293205,   Elsevier: Scopus)
14. Tomomi Kuwahara, Yositoshi Ogura, Kenshiro Oshima, Ken Kurokawa, Tadasuke Ooka, Hideki Hirakawa, Takehiko Itoh, Haruyuki Nakayama-Imaohji, Minoru Ichimura, Kikuji Itoh, Chieko Ishifune, Yoichi Maekawa, Koji Yasutomo, Masahira Hattori and Tetsuya Hayashi :
The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing.,
DNA Research, Vol.18, No.4, 291-303, 2011.
(DOI: 10.1093/dnares/dsr022,   PubMed: 21791478)
15. Chieko Ishifune, Yoichi Maekawa, Jun Nishida, Akiko Kitamura, Tanigaki Kenji, Yagita Hideo and Koji Yasutomo :
Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.,
European Journal of Immunology, Vol.41, No.5, 1309-1320, 2011.
(DOI: 10.1002/eji.201041159,   PubMed: 21469122)
16. Yoichi Maekawa, Yoshiaki Minato, Chieko Ishifune, Takeshi Kurihara, Akiko Kitamura, Hidefumi Kojima, Hideo Yagita, Mamiko Sakata-Yanagimoto, Toshiki Saito, Ichiro Taniuchi, Shigeru Chiba, Saburo Sone and Koji Yasutomo :
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.,
Nature Immunology, Vol.9, No.10, 1140-1147, 2008.
(DOI: 10.1038/ni.1649,   PubMed: 18724371)
17. Mika Kijima, Takeshi Yamaguchi, Chieko Ishifune, Yoichi Maekawa, Akemi Koyanagi, HIdeo Yagita, Shigeru Chiba, Kenji Kishihara, Mitsuo Shimada and Koji Yasutomo :
Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.105, No.19, 7010-7015, 2008.
(DOI: 10.1073/pnas.0709919105,   PubMed: 18458347)

Review, Commentary:

1. Chieko Ishifune and Koji Yasutomo :
Ahrによる腸管の恒常性制御 (レドックスUPDATE ストレス制御の臨床医学・健康科学に関する別冊号),
Journal of Clinical and Experimental Medicine, 90-95, Jul. 2015.
2. Chieko Ishifune and Koji Yasutomo :
The differentiation of intestinal dendtitic cells and the Notch signaling,
Clinical Immunology & Allergology, Vol.58, No.4, 382-386, Oct. 2012.
3. Chieko Ishifune and 安友 康二 :
IL-22 and the New IL-10 Family (IL-19, 20, 22, 24, 26),
細胞工学, Vol.31, No.7, 751-757, Jun. 2012.
(CiNii: 40019360575)
4. Chieko Ishifune and Koji Yasutomo :
NotchによるPARP1活性化はB細胞特異的に腫瘍化を抑制する,
血液内科, Vol.63, No.6, 734-739, Dec. 2011.
5. Chieko Ishifune and Koji Yasutomo :
Regulation of T cell homeostasis by Notch signaling,
Clinical Immunology & Allergology, Vol.55, No.5, 490-495, May 2011.
(CiNii: 40018868184)
6. Chieko Ishifune and Koji Yasutomo :
【樹状細胞による免疫制御と臨床応用 T細胞制御機構の理解から,樹状細胞療法の開発,自己免疫疾患・感染症の病態解明とその治療まで】 樹状細胞の生物学と生理学(分化・サブセット活性化・動態) Notchシグナルと樹状細胞分化,
Experimental Medicine, Vol.26, No.20, 3169-3174, Dec. 2008.
7. Chieko Ishifune and Koji Yasutomo :
【制御性T細胞の多様性と臨床応用】 微生物感染と制御性T細胞,
Inflammation & Immunology, Vol.15, No.4, 437-442, Jul. 2007.

Proceeding of International Conference:

1. Chieko Ishifune and Koji Yasutomo :
Notch signal controls TCR+CD8+ intestinal intraepithelial lymphocyte,
7th Joint Meeting of Tokushima University, Gifu University, KAIST, and Seoul National University, Seoul, Nov. 2018.
2. Chieko Ishifune, Shin-ichi Tsukumo and Koji Yasutomo :
Notch signal controls the number of TCR+CD8+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a2,
Australia-Japan Meeting on Cell Death, Tokyo, May 2018.
3. Chieko Ishifune, Yoichi Maekawa, Katsuto Hozumi and Koji Yasutomo :
Notch-STAT5b is central for the development of TCR alpha beta+ CD8 alpha alpha+ small intestinal intraepithelial lymphocytes,
16th International Congress of Immunology (ICI), Melbourne, Australia, Aug. 2016.
4. Chieko Ishifune and Koji Yasutomo :
Notch-STAT5b signaling regulates the TCRalpha beta+ CD8alpha alpha+ intraepithelial lymphocytes in the small intestine,
17th International Congress of Mucosal Immunology, Berlin, Jul. 2015.
5. Chieko Ishifune and Koji Yasutomo :
Notch signaling is essential for the differentiation of CX3CR1 positive cells in lamina propria of the small intestine,
2012 International Symposium on Dendritic Cells., Daegu, Oct. 2012.

Proceeding of Domestic Conference:

1. Chieko Ishifune and Koji Yasutomo :
Notch-mediated final differantiation of TCRgd+CD8aa+ intraepithelial lymphocyte in the small intestine,
The 47th Annual Meeting of The Japanease Society for Immunology, Dec. 2018.
2. Chieko Ishifune and Koji Yasutomo :
Notch-mediated final differantiation of TCRgd+CD8aa+ intraepithelial lymphocyte in the small intestine,
第47回 日本免疫学会学術集会, Dec. 2018.
3. Chieko Ishifune, Shin-ichi Tsukumo and Koji Yasutomo :
Notch signal controls the number of TCRab+CD8aa+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a2,
第46回 日本免疫学会学術集会, Dec. 2017.
4. Chieko Ishifune and Koji Yasutomo :
Notchシグナルによる細胞膜リン脂質の極性制御を介した腸管上皮間リンパ球の制御,
第32回自己免疫研究会, Jul. 2017.
5. Chieko Ishifune :
Notch シグナルによる腸管マクロファージと腸管上皮間 リンパ球の分化・恒常性制御,
東邦大学 第13回生化学セミナー, Apr. 2017.
6. Chieko Ishifune, Yoichi Maekawa and Koji Yasutomo :
Notch-Rbpj regulates Eat-Me singal of TCRab+CD8aa+ intraepithelial lymphocytes by controlling fllipase ATP8a2,
第45回日本免疫学会学術集会, Dec. 2016.
7. N Doi, Chieko Ishifune, Koji Yasutomo, T Miura, Y Sakai, K Fujimoto, S Harada, K Yoshimura, Masako Nomaguchi and Akio Adachi :
Replication and pathogenicity of HIV-1rmt: towards evaluation of viral growth ability in gut-derived cells,
第64回日本ウイルス学会学術集会, Oct. 2016.
8. Chieko Ishifune, Yoichi Maekawa, Katsuto Hozumi and Koji Yasutomo :
Notch-STAT5b is central for the differentiation of TCR alpha beta+ CD8 alpha alpha+ intraepithelial lymphocytes,
第44回日本免疫学会学術集会, Nov. 2015.
9. Chieko Ishifune, Maekawa Yoichi, Katsuto Hozumi and Koji Yasutomo :
Notch regulates the differentiation of TCRalpha beta+ CD8alpha alpha+ intraepithelial lymphocytes in the small intestine through Stat5b signaling,
第43回 日本免疫学会学術集会, Dec. 2014.
10. Chieko Ishifune, Yoichi Maekawa, Katsuto Hozumi and Koji Yasutomo :
Notch signaling regulates the differentiation of TCR alpha beta+ CD8alpha alpha+ Thy1- intraepithelial lymphocytes in the small intestine,
第42回日本免疫学会学術集会, Dec. 2013.
11. Chieko Ishifune, Yoichi Maekawa and Koji Yasutomo :
Notch signaling is essential for the differentiation of CX3CR1+ cell in lamina propria of the small intestine,
第41回日本免疫学会総会, Dec. 2012.

Et cetera, Workshop:

1. Chieko Ishifune and 安友 康二 :
難治性腸炎の発症に関わる腸管上皮細胞間リンパ球の分化制御,
第一回病因研究会別府シンポジウム, Jan. 2015.
2. Chieko Ishifune and 安友 康二 :
自己免疫性大腸炎におけるNotchシグナルによる腸管上皮間T細胞の維持調節,
自己免疫研究会, Jul. 2014.
3. Chieko Ishifune and Koji Yasutomo :
Requirement of Notch signaling for the development of intestinal intraepithelial T lymphocytes,
The Third Bizan Immunology Symposium at The University of Tokushima (BISUT3), "Immune System Development, Deviation, and Regulation", Feb. 2014.
4. Chieko Ishifune and Koji Yasutomo :
Notch-mediated regulation of intestinal CD11c+ cells,
The Second Immunology Symposium of The University of Tokushima Immune Development, Deviation, and Regulation 25 January 2013, Jan. 2013.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Notchシグナルによる小腸上皮間リンパ球の成熟・TCRレパトア調節機構の解明 (Project/Area Number: 18K15191 )
  • Elucidation of maintenance mechanism of intestinal homeostasis through control of small intestinal epithelial lymphocytes by Notch signal (Project/Area Number: 15K19131 )
  • Regulation of differentiation of the small intestinal lamina proprial CX3CR1-positive cells by the Notch signal. (Project/Area Number: 24890146 )
  • Search by Researcher Number (80632645)