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Academic Paper (Judged Full Paper):

1. Minoru Matsumoto, Koichi Tsuneyama, Junko Morimoto, Kazuyoshi Hosomichi, Mitsuru Matsumoto and Hitoshi Nishijima :
Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms.,
International Immunology, Vol.32, No.2, 117-131, 2020.
(Tokushima University Institutional Repository: 114944,   DOI: 10.1093/intimm/dxz066,   PubMed: 31586207)
2. Junko Morimoto, Yumiko Nishikawa, Takumi Kakimoto, Kohei Furutani, Naoki Kihara, Minoru Matsumoto, Koichi Tsuneyama, Yuko Kozono, Haruo Kozono, Katsuto Hozumi, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto :
Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G.,
The Journal of Immunology, Vol.201, No.11, 3244-3257, 2018.
(DOI: 10.4049/jimmunol.1800950,   PubMed: 30389776)
3. Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Minoru Matsumoto, Hiroshi Kawano, Yasuhiko Nishioka, Hisanori Uehara, Keisuke Izumi, Koichi Tsuneyama, Il-mi Okazaki, Taku Okazaki, Kazuyoshi Hosomichi, Ayako Shiraki, Makoto Shibutani, Kunitoshi Mitsumori and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).,
Journal of Autoimmunity, Vol.86, 75-92, 2018.
(Tokushima University Institutional Repository: 112347,   DOI: 10.1016/j.jaut.2017.09.006,   PubMed: 28931462)
4. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Yasuhiko Nishioka and Mitsuru Matsumoto :
Aire expression is inherent to most medullary thymic epithelial cells during their differentiation program.,
The Journal of Immunology, Vol.195, No.11, 5149-5158, 2015.
(DOI: 10.4049/jimmunol.1501000,   PubMed: 26503950)
5. Hitoshi Nishijima, Satsuki Kitano, Hitoshi Miyachi, Junko Morimoto, Hiroshi Kawano, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Kiyoshi Masuda, Issei Imoto, Koichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla.,
The Journal of Immunology, Vol.195, No.10, 4641-4649, 2015.
(DOI: 10.4049/jimmunol.1501026,   PubMed: 26453754,   Elsevier: Scopus)
6. Yasuhiro Mouri, Hitoshi Nishijima, Hiroshi Kawano, Fumiko Hirota, Nobuo Sakaguchi, Junko Morimoto and Mitsuru Matsumoto :
NF-κB-Inducing Kinase in Thymic Stroma Establishes Central Tolerance by Orchestrating Cross-Talk with Not Only Thymocytes but Also Dendritic Cells.,
The Journal of Immunology, Vol.193, No.9, 4356-4367, 2014.
(DOI: 10.4049/jimmunol.1400389,   PubMed: 25261487)
7. Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Joerg Hans Fehring, Yasuhiro Mouri and Mitsuru Matsumoto :
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.,
The Journal of Immunology, Vol.192, No.6, 2585-2592, 2014.
(DOI: 10.4049/jimmunol.1302786,   PubMed: 24516201,   Elsevier: Scopus)

Review, Commentary:

1. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
AIRE - The Autoimmune Regulator,
eLS, Feb. 2019.
(DOI: 10.1002/9780470015902.a0027281)
2. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Yasuhiro Mouri :
Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?,
Frontiers in Immunology, Vol.4, 1-4, Jul. 2013.
(DOI: 10.3389/fimmu.2013.00210,   PubMed: 23885257,   Elsevier: Scopus)

Proceeding of International Conference:

1. Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Characterization of Aire-expressing DCs with high-sensitivity and high-fidelity Aire-reporter strain,
The 48th Annual Meeting of the Japanese Society for Immunology, Hamamatsu, Japan, Dec. 2019.
2. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa and Hitoshi Nishijima :
Aire-dependent establishment of self-tolerance,
The 17th International Congress of Immunology, Beijing, Oct. 2019.
3. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa and Hitoshi Nishijima :
Aire-dependent establishment of self-tolerance studied by genetically modified mice,
EMBO Workshop ThymE, Israel, May 2019.
4. Minoru Matsumoto, Junko Morimoto, Mitsuru Matsumoto and Hitoshi Nishijima :
Tissue-specific autoimmunity modified by Aire in thymic and peripheral tolerance,
5th International Congress on Controversies in Rheumatology and Autoimmunity (CORA), Italy, Mar. 2019.
5. Mitsuru Matsumoto, Minoru Matsumoto, Junko Morimoto, Koichi Tsuneyama and Hitoshi Nishijima :
Tissue-specific autoimmunity manipulated by Aire in thymic and peripheral tolerance,
Immunology of Diabetes Society Congress 2018, London, Oct. 2018.
6. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto and Hitoshi Nishijima :
Aire controls in trans the production of medullary thymic epithelial cells expressing Ly6C/Ly6G,
5th European Congress of Immunology 2018, Amsterdam, Sep. 2018.
7. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto and Mitsuru Matsumoto :
Distinct tissue-specific immune response revealed by manipulation of thymic and peripheral tolerance by Aire,
1st International Symposium for "Neo-self", Awaji, Japan, Jul. 2018.
8. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity,
11th International Congress on Autoimmunity, Lisbon, Portugal, May 2018.
9. Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto :
Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells,
Immunology 2018 - AAI Annual Meeting, Austin, Texas, May 2018.
10. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama and Hitoshi Nishijima :
A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression,
ThymOz8, Heron Island, Australia, Mar. 2018.
11. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD,
ThymOz8, Heron Island, Australia, Mar. 2018.
12. Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto :
Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells,
5th Annual Meeting of the International Cytokine and Interferon Society, Kanazawa, Japan, Oct. 2017.
13. Junko Morimoto, Yumiko Nishikawa, Hitoshi Nishijima and Mitsuru Matsumoto :
Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function,
12th International Congress on SLE, Melbourne, Australia, Mar. 2017.
14. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE,
7th International Workshop of Kyoto T Cell Conference, Kyoto, Japan, Mar. 2017.
15. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice,
Controversies in Rheumatology and Autoimmunity 2017, Bologna, Italy, Mar. 2017.
16. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto :
Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program,
The 4th European Congress of Immunology, Vienna, Austria, Sep. 2015.
17. Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka :
Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program,
Venice Thymus Meeting 2015, Venice, Italy, Apr. 2015.
18. Hitoshi Nishijima, Junko Morimoto, Hiroshi Kawano, Yasuhiro Mouri, Koichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment,
ThymOz 7, Heron Island, Australia, Apr. 2014.
19. Mitsuru Matsumoto, Junko Morimoto, Hiroshi Kawano, Yasuhiro Mouri and Hitoshi Nishijima :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary microenvironment,
9th International Congress on Autoimmunity, Nice, France, Mar. 2014.
20. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Yumiko Nishikawa, Kouichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor within medullary microenvironment,
第3回 眉山免疫シンポジウム, Feb. 2014.

Proceeding of Domestic Conference:

1. Junko Morimoto, Hitoshi Nishijima, 松本 稔 and Mitsuru Matsumoto :
Treg誘導に 関与する胸腺内樹状細胞サブセットとAireの機能解析.第2回若手の会(新学術領域ネオセルフの生成・機能・構造)(静岡)1月10~11日,2019.,
2. Junko Morimoto, Hitoshi Nishijima, 松本 稔 and Mitsuru Matsumoto :
Antigen Transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs. The 48th Annual meeting of the Japanese Society for Immunology, Hamamatsu, Japan. Dec. 2019,
3. Hitoshi Nishijima, Mizuki Sugita, Junko Morimoto, Minoru Matsumoto and Mitsuru Matsumoto :
Functional and transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression,
第42回日本分子生物学会年会, Dec. 2019.
4. Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Mitsuru Matsumoto :
Transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression,
第47回日本免疫学会学術集会, Dec. 2018.
5. Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto and Mitsuru Matsumoto :
Analysis of the role of thymic APCs and Aire in the production of thymic Tregs,
第47回日本免疫学会学術集会, Dec. 2018.
6. Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Mitsuru Matsumoto :
胸腺髄質上皮細胞における Aire 発現レベルと組織特異的自己抗原 遺伝子発現との関連性に関する検討,
28 Kyoto T cell Conference (KTCC), Jun. 2018.
7. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the impaired presentation of self-antigens in the pancreas,
第46回日本免疫学会学術集会, Dec. 2017.
8. Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity,
第45回日本免疫学会学術集会, Dec. 2016.
9. Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein,
第44回日本免疫学会学術集会, Nov. 2015.
10. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE,
第44回日本免疫学会学術集会, Nov. 2015.
11. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Hiroshi Kawano, Koichi Ikuta and Mitsuru Matsumoto :
Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex,
第43回日本免疫学会学術集会, Dec. 2014.
12. Hiroshi Kawano, Junko Morimoto, Yasuhiro Mouri, Hitoshi Nishijima, Yasuhiko Nishioka and Mitsuru Matsumoto :
Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells,
第43回日本免疫学会学術集会, Dec. 2014.
13. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Yumiko Nishikawa, Kouichi Ikuta and Mitsuru Matsumoto :
Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance,
第42回日本免疫学会総会, Dec. 2013.

Et cetera, Workshop:

1. Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析,
第36回日本胸腺研究会, Feb. 2017.
2. Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano and Mitsuru Matsumoto :
NOD系統特異的に多発性筋炎様症状をもたらすゲノム領域の解析,
第14回四国免疫フォーラム, Jun. 2015.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • GPIアンカー型タンパク質Ly6C分子による免疫応答調節機構の解明 (Project/Area Number: 19K07626 )
  • AIREを基軸とする自己免疫疾患の病態解明、ならびに新規治療法の開発 (Project/Area Number: 19H03699 )
  • 自己免疫病態におけるアンビバレンス(両価性)の解読 (Project/Area Number: 18K19564 )
  • Elucidation of the pathogenesis of autoimmune disease through the functional study of AIRE (Project/Area Number: 16H05342 )
  • Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function (Project/Area Number: 26460577 )
  • 新規マクロファージ亜群の同定とその生体内自己免疫反応制御における意義 (Project/Area Number: 22021003 )
  • The role of osteopontin in the generation of memory CD8 T cells during influenza virus infection (Project/Area Number: 22790449 )
  • Molecular basis for the functional regulation of intractable inflammatory disorders by Osteopontin (Project/Area Number: 21390113 )
  • The roles of osteopontin and IL-17 in the protective immune responses against virus infection (Project/Area Number: 20790365 )
  • Search by Researcher Number (20451396)