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Tokushima University > Graduate School of Biomedical Sciences > 薬学域 > 先端薬学教育研究プロジェクト >
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Tokushima University > Research Clusters > Research Clusters (Registered) > 1704091 細胞内代謝に焦点をあてたシェーグレン症候群の新規治療薬の開発 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1704046 生体における活性イオウの生理機能解析とその臨床応用 >
Tokushima University > Graduate School of Pharmaceutical Sciences > Pharmaceutical Sciences >
Tokushima University > Faculty of Pharmaceutical Sciences > School of Pharmaceutical Technosciences > 創薬学講座 > Pharmaceutical Organic Chemistry >
Tokushima University > Research Clusters > Research Clusters (Prioritized) > 1802001 有機合成化学を起点とするセンシング技術の開発と応用 >
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Research Activity

Field of Study

Synthetic Organic Chemistry, Bioorganic Chemistry

Subject of Study

Development of novel asymmetric reactions, Development of novel methodology for synthesis of biomolecules and their analogues (organocatalysts, 触媒的不斉合成, 異常アミノ酸, peptide synthesis)

Book / Paper

Academic Paper (Judged Full Paper):

1. Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor,
Chemistry - A European Journal, Vol.25, 2019.
(DOI: 10.1002/chem.201903572)
2. Chiaki Komiya, Akira Shigenaga, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence,
Chemical Communications, Vol.55, 7029-7032, 2019.
(DOI: 10.1039/C9CC03583D,   PubMed: 31140482,   Elsevier: Scopus)
3. Hiroki Kiyama, Tsubasa Inokuma, Yusuke Kuroda, Yousuke Yamaoka, Kiyosei Takasu and Ken-ichi Yamada :
Optical Resolution via Catalytic Generation of Chiral Auxiliary,
Tetrahedron Letters, Vol.60, No.2, 175-177, 2018.
(Tokushima University Institutional Repository: 113449,   DOI: 10.1016/j.tetlet.2018.12.006,   Elsevier: Scopus)
4. Takahisa Jichu, Tsubasa Inokuma, Keisuke Aihara, Taiki Kohiki, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka :
A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst,
ChemCatChem, Vol.10, No.16, 3402-3405, 2018.
(Tokushima University Institutional Repository: 111892,   DOI: 10.1002/cctc.201800714)
5. Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka :
Direct enantioselective indolylation of peptidyl imine for the synthesis of indolyl glycine-containing peptides,
Heterocycles, Vol.97, No.2, 1269-1287, 2018.
(DOI: 10.3987/COM-18-S(T)86)
6. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Resin-bound crypto-thioester for native chemical ligation,
Organic Letters, Vol.20, No.8, 2449-2453, 2018.
(Tokushima University Institutional Repository: 111890,   DOI: 10.1021/acs.orglett.8b00795)
7. Tsubasa Inokuma and Sato Sinichi :
Chemical Biology for Pharmaceutical Sciences (Development of Practical Chemical Biotechnology),
Journal of the Pharmaceutical Society of Japan, Vol.138, No.1, 37-38, 2018.
(DOI: 10.1248/yakushi.17-00186-F,   PubMed: 29311463,   Elsevier: Scopus)
8. Taiki Kohiki, Yusuke Nishikawa, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Chemical synthetic platform for chlorpromazine oligomers that were reported as photo-degradation products of chlorpromazine,
Chemical & Pharmaceutical Bulletin, Vol.65, No.12, 1161-1166, 2017.
(Tokushima University Institutional Repository: 111929,   DOI: 10.1248/cpb.c17-00692,   PubMed: 29199220,   Elsevier: Scopus)
9. Keisuke Aihara, Tsubasa Inokuma, Takahisa Jichu, Zhenjian Lin, Feixue Fu, Kosuke Yamaoka, Akira Shigenaga, David A. Hutchins, Eric W. Schmidt and Akira Otaka :
Cysteine-free intramolecular ligaiton of N-sulfanylethylanilide peptide using 4-mercaptobenzylphosphonic acid: Synthesis of cyclic peptide, trichamide,
Synlett, Vol.28, No.15, 1944-1949, 2017.
(Tokushima University Institutional Repository: 111889,   DOI: 10.1055/s-0036-1589055)
10. Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Inside Front Cover: Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology,
Organic & Biomolecular Chemistry, Vol.15, 5240, 2017.
(DOI: 10.1039/C7OB90109G)
11. Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology,
Organic & Biomolecular Chemistry, Vol.15, No.25, 5289-5297, 2017.
(Tokushima University Institutional Repository: 111927,   DOI: 10.1039/C7OB00633K)
12. Tsubasa Inokuma, Takahisa Jichu, Kodai Nishida, Akira Shigenaga and Akira Otaka :
A convenient method for preparation of -imino carboxylic acid derivatives and application to the asymmetric synthesis of unnatural -amino acid derivative,
Chemical & Pharmaceutical Bulletin, Vol.65, No.6, 573-581, 2017.
(DOI: 10.1248/cpb.c17-00158,   PubMed: 28566650)
13. Mitsuhiro Eto, Naoto Naruse, Kyohei Morimoto, Kosuke Yamaoka, Kohei Sato, Kohei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of an anilide-type scaffold for the thioester precursor N-sulfanylethylcoumarinyl amide,
Organic Letters, Vol.18, No.17, 4416-4419, 2016.
(Tokushima University Institutional Repository: 111879,   DOI: 10.1021/acs.orglett.6b02207,   PubMed: 27529363)
14. Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka :
Back Cover: Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library,
ChemBioChem, Vol.17, No.20, 1994, 2016.
(DOI: 10.1002/cbic.201600521)
15. Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka :
Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library,
ChemBioChem, Vol.17, No.20, 1986-1992, 2016.
(Tokushima University Institutional Repository: 111880,   DOI: 10.1002/cbic.201600400,   PubMed: 27428709,   Elsevier: Scopus)
16. Masaya Denda, Takuya Morisaki, Taiki Kohiki, Jun Yamamoto, Kohei Sato, Ikuko Sagawa, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide,
Organic & Biomolecular Chemistry, Vol.14, 6244-6251, 2016.
(Tokushima University Institutional Repository: 111885,   DOI: 10.1039/C6OB01014H)
17. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Kouji Itou, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
An N-Sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins,
Chemical Communications, Vol.52, 6911-6913, 2016.
(Tokushima University Institutional Repository: 111925,   DOI: 10.1039/C6CC01229A)
18. Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki :
Identification of SNAIL1 Peptide-Based Irreversible Lysine Specific Demethylase 1-Selective Inactivators,
Journal of Medicinal Chemistry, Vol.59, No.4, 1531-1544, 2016.
(DOI: 10.1021/acs.jmedchem.5b01323,   PubMed: 26700437)
19. Chiaki Komiya, Keisuke Aihara, Kou Morishita, Hao Ding, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of an intein-inspired amide cleavage chemical device,
The Journal of Organic Chemistry, Vol.81, No.2, 699-707, 2016.
(Tokushima University Institutional Repository: 111896,   DOI: 10.1021/acs.joc.5b02399,   PubMed: 26646813)
20. Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot/sequential native chemical ligation using photo-caged crypto-thioester,
Organic Letters, Vol.18, No.3, 596-599, 2016.
(DOI: 10.1021/acs.orglett.5b03661,   PubMed: 26753720)
21. Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga, Miki Imanishi, Shiro Futaki and Akira Otaka :
Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis,
Biopolymers, Vol.106, No.4, 531-546, 2015.
(Tokushima University Institutional Repository: 111898,   DOI: 10.1002/bip.22757,   PubMed: 26501985)
22. Kohei Tsuji, Kosuke Tanegashima, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka :
Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation,
Bioorganic & Medicinal Chemistry, Vol.23, No.17, 5909-5914, 2015.
(DOI: 10.1016/j.bmc.2015.06.064,   PubMed: 26187016,   Elsevier: Scopus)
23. Miku Kita, Jun Yamamoto, Takuya Morisaki, Chiaki Komiya, Tsubasa Inokuma, Licht Miyamoto, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka :
Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide,
Tetrahedron Letters, Vol.56, No.28, 4228-4231, 2015.
(Tokushima University Institutional Repository: 111909,   DOI: 10.1016/j.tetlet.2015.05.060,   Elsevier: Scopus)
24. Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Naoto Naruse, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka :
The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate,
Chemical Communications, Vol.51, No.49, 9946-9948, 2015.
(Tokushima University Institutional Repository: 111882,   DOI: 10.1039/C5CC02967H,   PubMed: 26006093,   Elsevier: Scopus)
25. Keisuke Aihara, Tsubasa Inokuma, Chiaki Komiya, Akira Shigenaga and Akira Otaka :
Synthesis of lactam-bridged cyclic peptides by using olefin metathesis and diimide reduction,
Tetrahedron, Vol.71, No.24, 4183-4191, 2015.
(Tokushima University Institutional Repository: 111884,   DOI: 10.1016/j.tet.2015.04.093,   Elsevier: Scopus)
26. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Development of chemical methodology for preparation of peptide thioesters applicable to naturally occurring peptides using a sequential quadruple acyl transfer system,
ChemistryOpen, Vol.4, No.4, 448-452, 2015.
(Tokushima University Institutional Repository: 111883,   DOI: 10.1002/open.201500086,   Elsevier: Scopus)
27. Tsubasa Inokuma, Fuller P Roberta and III F Barbas Carlos :
N-Sulfonyl-β-lactam hapten as an effective labeling reagent for aldolase mAb,
Bioorganic & Medicinal Chemistry Letters, Vol.25, No.8, 1684-1687, 2015.
(DOI: 10.1016/j.bmcl.2015.03.011,   PubMed: 25791455)
28. Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka :
Liquid-phase synthesis of bridged peptides using olefin metathesis of protected peptide with long aliphatic chain anchor,
Organic Letters, Vol.17, No.3, 696-699, 2015.
(Tokushima University Institutional Repository: 111891,   DOI: 10.1021/ol503718j,   PubMed: 25629979,   Elsevier: Scopus)
29. Tsuji Nobuya, Stadler Michael, Kazumi Naoya, Tsubasa Inokuma and Takemoto Yoshiji :
Catalytic asymmetric synthesis of the pentacyclic core of (-)-nakadomarin A via oxazolidine as an iminium cation equivalent,
Organic & Biomolecular Chemistry, Vol.12, No.40, 7919-7922, 2014.
(DOI: 10.1039/c4ob01678e,   PubMed: 25216237,   Elsevier: Scopus)
30. Azuma Takumi, Murata Akihiro, Kobayashi Yusuke, Tsubasa Inokuma and Takemoto Yoshiji :
A Dual Arylboronic Acid-Aminothiourea Catalytic System for the Asymmetric Intramolecular Hetero-Michael Reaction of a,b-Unsaturated Carboxylic Acids,
Organic Letters, Vol.16, No.16, 4256-4259, 2014.
(DOI: 10.1021/ol501954r,   PubMed: 25075571,   Elsevier: Scopus)
31. Koji Ebisuno, Masaya Denda, Keiji Ogura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein,
Bioorganic & Medicinal Chemistry, Vol.22, No.11, 2984-2991, 2014.
(Tokushima University Institutional Repository: 111910,   DOI: 10.1016/j.bmc.2014.04.002,   PubMed: 24768166,   Elsevier: Scopus)
32. Kobayashi Yusuke, Taniguchi Yamato, Hayama Noboru, Tsubasa Inokuma and Takemoto Yoshiji :
A Powerful Hydrogen-Bond-Donating Organocatalyst for the Enantioselective Intramolecular Oxa-Michael Reaction of ,-Unsaturated Amides and Esters,
Angewandte Chemie International Edition, Vol.52, 11114-11118, 2013.
(DOI: 10.1002/anie.201305492,   PubMed: 24039087,   Elsevier: Scopus)
33. Sato Shinichi, Tsubasa Inokuma, Otsubo Nobumasa, Barton R Denis and III F Barbas Carlos :
Chemically Programmed Antibodies As HIV-1 Attachment Inhibitors,
ACS Medicinal Chemistry Letters, Vol.4, No.5, 460-465, 2013.
(DOI: 10.1021/ml400097z,   PubMed: 23750312)
34. Ban Hitoshi, Nagano Masanobu, Gavrilyuk Julia, Hakamata Wataru, Tsubasa Inokuma and III F Barbas Carlos :
Facile and Stabile Linkages through Tyrosine: Bioconjugation Strategies with the Tyrosine-Click Reaction,
Bioconjugate Chemistry, Vol.24, No.4, 520-532, 2013.
(DOI: 10.1021/bc300665t,   PubMed: 23534985,   Elsevier: Scopus)
35. Uno Takuya, Tsubasa Inokuma and Takemoto Yoshiji :
NHC-catalyzed thioesterification of aldehydes by external redox activation,
Chemical Communications, Vol.48, 1901-1903, 2012.
(DOI: 10.1039/c2cc17183j,   PubMed: 22228405,   Elsevier: Scopus)
36. Tsubasa Inokuma, Furukawa Masaya, Suzuki Yusuke, Kimachi Tetsutaro, Kobayashi Yusuke and Takemoto Yoshiji :
Organocatalyzed Isomerization of a-Substituted Alkynoates into Trisubstituted Allenoates by Dynamic Kinetic Resolution,
ChemCatChem, Vol.4, 983-985, 2012.
(DOI: 10.1002/cctc.201200065)
37. Sakamoto Shota, Tsubasa Inokuma and Takemoto Yoshiji :
Organocatalytic asymmetric Neber reaction for the synthesis of 2H-azirine carboxylic esters,
Organic Letters, Vol.13, No.24, 6374-6377, 2011.
(DOI: 10.1021/ol2026747,   PubMed: 22107059,   Elsevier: Scopus)
38. Tsubasa Inokuma, Furukawa Masaya, Uno Takuya, Suzuki Yusuke, Yoshida Kozo, Yano Yoshiaki, Matsuzaki Katsumi and Takemoto Yoshiji :
Bifunctional Hydrogen-Bond Donors That Bear a Quinazoline or Benzothiadiazine Skeleton for Asymmetric Organocatalysis,
Chemistry - A European Journal, Vol.17, No.37, 10470-10477, 2011.
(DOI: 10.1002/chem.201101338,   PubMed: 21812044,   Elsevier: Scopus)
39. Takao Tamura, Akiko Kuwahara, Kaori Kadoyama, Motohiro Yamamori, Kohshi Nishiguchi, Tsubasa Inokuma, Yoshiji Takemoto, Naoko Chayahara, Tatsuya Okuno, Ikuya Miki, Yoshimi Fujishima and Toshiyuki Sakaeda :
Effects of Bolus Injection of 5-Fluorouracil on Steady-State Plasma Concentrations of 5-Fluorouracil in Japanese Patients with Advanced Colorectal Cancer,
International Journal of Medical Sciences, Vol.8, No.5, 406-412, 2011.
(DOI: 10.7150/ijms.8.406,   PubMed: 21750645)
40. Tsubasa Inokuma, Suzuki Yusuke, Sakaeda Toshiyuki and Takemoto Yoshiji :
Synthesis of Optically Active N-Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy-Thiourea Catalyst,
Chemistry - An Asian Journal, Vol.6, 2902-2906, 2011.
(DOI: 10.1002/asia.201100453,   PubMed: 21815270,   Elsevier: Scopus)
41. Yoshida Kozo, Tsubasa Inokuma, Takasu Kiyosei and Takemoto Yoshiji :
Catalytic asymmetric synthesis of both enantiomers of 4-substituted 1,4-dihydropyridines with the use of bifunctional thiourea-ammonium salts bearing different counterions,
Molecules, Vol.15, No.11, 8305-8326, 2010.
(DOI: 10.3390/molecules15118305,   PubMed: 21079568,   Elsevier: Scopus)
42. Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Kaori Kadoyama, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka and Toshiyuki Sakaeda :
Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma,
International Journal of Medical Sciences, Vol.7, No.1, 48-54, 2010.
(DOI: 10.7150/ijms.7.48,   PubMed: 20151048)
43. Yoshida Kozo, Tsubasa Inokuma, Takasu Kiyosei and Takemoto Yoshiji :
Brønsted acid-thiourea co-catalysis: asymmetric synthesis of functionalized 1,4-dihydropyridines from b-enamino esters and a,b-unsaturated aldehydes,
Synlett, 1865-1869, 2010.
(DOI: 10.1055/s-0030-1258090)
44. Kuwahara Akiko, Yamamori Motohiro, Nishiguchi Kohshi, Okuno Tatsuya, Chayahara Naoko, Miki Ikuya, Tamura Takao, Tsubasa Inokuma, Takemoto Yoshiji, Nakamura Tsutomu, Kataoka Kazusaburo and Sakaeda Toshiyuki :
Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma,
International Journal of Medical Sciences, Vol.6, No.6, 305-311, 2009.
(DOI: 10.7150/ijms.6.305,   PubMed: 19834547,   Elsevier: Scopus)
45. Tsubasa Inokuma, Takasu Kiyosei, Sakaeda Toshiyuki and Takemoto Yoshiji :
Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Addition of ,-Unsaturated Ketones with Alkenylboronic Acids,
Organic Letters, Vol.11, No.11, 2425-2428, 2009.
(DOI: 10.1021/ol9006053,   PubMed: 19402642,   Elsevier: Scopus)
46. Tsubasa Inokuma, Sakamoto Shota and Takemoto Yoshiji :
Enantioselective nitrocyclopropanation of α,β-unsaturated α-cyanoimides catalyzed by bifunctional thiourea,
Synlett, Vol.10, 1627-1630, 2009.
(DOI: 10.1055/s-0029-1217331)
47. Tsubasa Inokuma, Nagamoto Yuuki, Sakamoto Shota, Miyabe Hideto, Takasu Kiyosei and Takemoto Yoshiji :
Asymmetric synthesis of 4-substituted 2,6-dioxopiperidine-3-carbonitrile by using thiourea-catalyzed asymmetric Michael addition,
Heterocycles, Vol.79, 573-582, 2009.
(DOI: 10.3987/COM-08-S(D)18)
48. Tsubasa Inokuma, Hoashi Yasutaka and Takemoto Yoshiji :
Thiourea-Catalyzed Asymmetric Michael Addition of Activated Methylene Compounds to ,-Unsaturated Imides: Dual Activation of Imide by Intra- and Intermolecular Hydrogen Bonding,
Journal of the American Chemical Society, Vol.128, No.29, 9413-9419, 2006.
(DOI: 10.1021/ja061364f,   PubMed: 16848477,   Elsevier: Scopus)
49. Yanada Reiko, Obika Shingo, Tsubasa Inokuma, Yanada Kazuo, Yamashita Masayuki, Ohta Shunsaku and Takemoto Yoshiji :
Stereoselective Synthesis of 3-Alkylideneoxindoles via Palladium-Catalyzed Domino Reactions,
The Journal of Organic Chemistry, Vol.70, No.17, 6972-6975, 2005.
(DOI: 10.1021/jo0508604,   PubMed: 16095329)
50. Reiko Yanada, Shingo Obika, Yusuke Kobayashi, Tsubasa Inokuma, Munetaka Oyama, Kazuo Yanada and Yoshiji Takemoto :
Stereoselective Synthesis of 3-Alkylideneoxindoles using Tandem Indium-Mediated Carbometallation and Palladium-Catalyzed Cross-Coupling Reactions,
Advanced Synthesis & Catalysis, Vol.347, No.11-13, 1632-1642, 2005.
(DOI: 10.1002/adsc.200505147,   Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis,
Peptide Science 2018, 8, 2019.
2. Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Development and application of novel protein labeling reagent "SEAL",
Peptide Science 2018, 104, 2019.
3. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima and Tsubasa Inokuma :
Development of methodology for producing thioesters from naturally occurring peptide sequence,
Peptide Science 2017, 86-87, 2018.
4. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis,
Peptide Science 2017, 32-33, 2018.
5. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Development of methodology for producing thioesters from naturally occurring peptide sequence,
Peptide Science 2017, 86-87, 2018.
6. Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki :
Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors,
Peptide Science 2016, 165-166, 2017.
7. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot sequential native chemical ligations using photocaged crypto-thioester,
Peptide Science 2016, 73-74, 2017.
8. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
Development of N-sulfanyltehylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins,
Peptide Science 2016 [PRESTO], 179-181, 2017.
9. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka :
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library,
Peptide Science 2016, 75-76, 2017.
10. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Intein-inspired amide bond processing device,
EPS Proceedings 2016, 60, 2016.
11. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Second-generation synthetic strategy of GM2-activator protein (GM2AP) analogues applicable to the preparation of a protein library,
EPS Proceedings 2016, 63, 2016.
12. Keisuke Aihara, Kohsuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot/sequential native chemical ligation using photo-responsive crypto-thioester,
EPS Proceedings 2016, 39, 2016.
13. Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol,
Peptide Science 2015, 21-22, 2016.
14. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of intein-inspired peptide bond processing device,
Peptide Science 2015, 281-282, 2016.
15. Kohei Tsuji, Kohei Sato, Mitsuhiro Eto, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide (SEAlide) peptide as a versatile intermediate for protein chemical synthesis using native chemical ligation,
Peptide Science 2014, 113-116, 2015.

Review, Commentary:

1. Akira Shigenaga, Jun Yamamoto, Taiki Kohiki, Tsubasa Inokuma and Akira Otaka :
Invention of stimulus-responsive peptide-bond-cleaving residue (Spr) and its application to chemical biology tools,
Journal of Peptide Science, Vol.23, 505-513, Aug. 2017.
(Tokushima University Institutional Repository: 111930,   DOI: 10.1002/psc.2961,   PubMed: 28105728)
2. Yusuke Tsuda, Akira Shigenaga, Kouhei Satou, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発,
ケミカルバイオロジー, Vol.9, 7-10, Jun. 2016.
3. Kobayashi Yusuke, Tsubasa Inokuma and Takemoto Yoshiji :
Development of Innovative HydrogenBondDonor Catalysts Based on Heterocyclic Scaff olds and Their Applications to Asymmetric Reactions,
Journal of Synthetic Organic Chemistry, Japan, Vol.71, No.5, 491-502, 2013.

Proceeding of International Conference:

1. Ken-ichi Yamada, Yinli Wang, Satoru Kuwano, Tsubasa Inokuma, Yousuke Yamaoka and Kiyosei Takasu :
The Enhancement of Enantio-recognition in Kinetic Resolution of Chiral Secondary Alcohols with Chiral Acyltriazolium by Formation of AlcoholCarboxylate Complexes,
27th International Society of Heterocyclic Chemistry Congress, Sep. 2019.
2. Ken-ichi Yamada, Yinli Wang, Satoru Kuwano, Tsubasa Inokuma, Yousuke Yamaoka and Kiyosei Takasu :
The Enhanced Enantio-recognition of Chiral Acylazolium in Kinetic Resolution of Chiral Secondary Alcohol by Carboxylate Additive,
The 4th International Symposium on Process Chemistry (ISPC 2019), Jul. 2019.
3. Ken-ichi Yamada, Wang Yinli, Kuwano Satoru, Tsubasa Inokuma, Yamaoka Yousuke and Takasu Kiyosei :
NHC-Carboxylate Dual Catalysis in Kinetic Resolution of α-Hydroxy Thioamide by Acylation,
The 1st International Symposium on Hybrid Catalysis for Enabling Molecular Synthesis on Demand, Tokyo, May 2019.
4. Akira Shigenaga, Takuya Morisaki, Taiki Kohiki, Masaya Denda, Tsubasa Inokuma and Akira Otaka :
Development of acyl transfer-based chemical biology tools for purification/selective labeling of target proteins,
5th International Symposium for Medicinal Sciences, Chiba, Mar. 2019.
5. Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
Development and application of novel protein labeling reagent "SEAL",
10th International Peptide Symposium, Kyoto, Dec. 2018.
6. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis,
10th International Peptide Symposium, Kyoto, Dec. 2018.
7. Yusuke Kato, Nobuo Maita, Taiki Kohiki, Sumire Kurosawa, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Kazuko YORITA, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui :
Combined approach of computation and enzymology to investigate novel D-amino acid oxidase inhibitors,
The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine and the 28th Hot Spring Harbor Symposium, Fukuoka, Oct. 2018.
8. Tsubasa Inokuma, Nishida Kodai, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka :
Novel methodology for the synthesis of-indolyl-glycine containing peptidevia direct asymmetric FriedelCrafts reactionto peptidyl imine,
35th European Peptide Symposium, Dublin, Ireland, Aug. 2018.
9. Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui :
Studies on binding molecules to D-amino acid oxidase using computational approaches,
The 12th International Symposium of the Institute Network, Tokyo, Nov. 2017.
10. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
Development of N-Sulfanylethylanilide-based Traceable Linker for Purification and Selective Labeling of Target Proteins,
American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017.
11. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of methodology for preparation of peptide thioester via on-resin N-S acyl transfer using N-sulfanylethylanilide peptide,
American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017.
12. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Second-Generation Synthetic Strategy of GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library,
34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016.
13. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Intein-inspired Amide Bond Processing Device,
34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016.
14. Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-Pot/Sequential Native Chemical Ligation Using Photo-responsive Crypto-thioester,
34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016.
15. Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Development of Chemistry-based Protocol for Sequence-dependent Thioesterification,
American Peptide Symposium 2015, Florida, Jun. 2015.
16. Masaya Denda, Takuya Morisaki, Jun Yamamoto, Kohei Sato, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
In Cell Labeling of Target Proteins using ''SEAL-tag'',
American Peptide Symposium 2015, Florida, Jun. 2015.
17. Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka :
Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional control,
The 2nd International Symposium on Fusion Materials Program, Tokyo, Nov. 2014.

Proceeding of Domestic Conference:

1. Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Development of the direct asymmetric indolylation of imino peptide for synthesis of indolylglycine-containing peptide,
第56回ペプチド討論会, Oct. 2019.
2. Daishiroh Kobayashi, Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant,
第56回ペプチド討論会, Oct. 2019.
3. Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Development of Novel Methodology for the Synthesis of Non-Proteinogenic Amino Acid-Containing Peptide via Direct Asymmetric Reaction to Peptidyl Substrate,
日本ケミカルバイオロジー学会第14回年会, Jun. 2019.
4. Ken-ichi Yamada, 木山 大樹, Tsubasa Inokuma, 黒田 悠介, 山岡 庸介 and 高須 清誠 :
Optical Resolution via Catalytic Formation of Chiral Auxiliary,
日本薬学会第139年会, Mar. 2019.
5. Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
Synthesis of indolyl glycine-containing peptide via direct asymmetric reaction to peptide,
日本薬学会第139年会, Mar. 2019.
6. Akiho Yamauchi, Inriki Wan, Tsubasa Inokuma, 山岡 庸介, 高須 清誠 and Ken-ichi Yamada :
Effects of N-Substituent on Kinetic Resolution of -Hydroxy Amide,
日本薬学会第139年会, Mar. 2019.
7. Tsubasa Inokuma :
ペプチドへの直接的不斉反応による異常アミノ酸含有ペプチド合成法の開発,
大阪大学蛋白質研究所セミナー 「30代研究者が切り拓くタンパク質化学合成の新潮流」, Mar. 2019.
8. Ken-ichi Yamada, 木山 大樹, Tsubasa Inokuma, 黒田 悠介, 山岡 庸介 and 高須 清誠 :
触媒的ジアステレオマー法によるキラルアルコール類の光学分割,
第11回 有機触媒シンポジウム, Dec. 2018.
9. Sakakibara Takuya, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
非天然側鎖構造を有するα-アミノリン酸の実用的不斉合成,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018.
10. Okada Kazuki, Tsubasa Inokuma and Ken-ichi Yamada :
ホモセリン類含有ペプチドの効率的合成を志向した不斉Mannich 反応の検討,
第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018.
11. Tsubasa Inokuma, Kazuki Okada, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
ペプチドイミンに対する不斉1,2-付加を基盤とする非天然アミノ酸含有ペプチドの不斉合成,
第44回反応と合成の進歩シンポジウム, Nov. 2018.
12. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移速度 の向上を指向した新規補助基の開発,
第50回若手ペプチド夏の勉強会, Aug. 2018.
13. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
On-resinチオエス テル化法から得られた知見とその応用,
第50回若手ペプチド夏の勉強会, Aug. 2018.
14. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
加水分解酵素を利用したC末端特異的チオエステル化反応の開発,
第50回若手ペプチド夏の勉強会, Aug. 2018.
15. Ken-ichi Yamada, Inriki Wan, Tsubasa Inokuma, 山岡 庸介 and 高須 清誠 :
Kinetic Resolution of alpha-Hydroxy-Caraboxylic-Acid Derivateives Using a Chiral NHC Catalyst,
日本プロセス化学会 2018 サマーシンポジウム, Jul. 2018.
16. Masuda Sakyo, Goto Kengo, Nakayama Takamori, Tsubasa Inokuma and Ken-ichi Yamada :
構造活性相関研究を志向したPancratistatin誘導体の立体網羅的合成,
創薬懇話会 2018 in 志賀島, Jun. 2018.
17. Takuya Sakakibara, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada :
安定なイミンを用いたα-アミノリン酸の実用的不斉合成,
創薬懇話会 2018 in 志賀島, Jun. 2018.
18. Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
発現タンパク質に適用可能な新規チオエステル合成法の開発,
創薬懇話会 2018 in 志賀島, Jun. 2018.
19. Ken-ichi Yamada, Inriki Wan, 鍬野 哲, Tsubasa Inokuma, 山岡 庸介 and 高須 清誠 :
The Enhanced Enantio-recognition of Chiral Acylazolium in Kinetic Resolution of Chiral Secondary Alcohol by Formation of AlcoholCarboxylate Complex,
モレキュラーキラリティー2018, May 2018.
20. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
均一修飾タンパク質の合成を指向したタンパク質C末端特異的活性化反応の開発,
日本薬学会第138年会, Mar. 2018.
21. Kentaroh Hashimoto, Inriki Wan, 鍬野 哲, 高須 清誠, Tsubasa Inokuma and Ken-ichi Yamada :
Remote Electronic Tuning of Chiral NHC Catalysts in the Asymmetric Benzoin Reaction,
日本薬学会第138年会, Mar. 2018.
22. Akiho Yamauchi, 宮川 泰典, Inriki Wan, 高須 清誠, Tsubasa Inokuma and Ken-ichi Yamada :
Development of Catalytic Asymmetric Migrative Cyclization of Sulfonyl Alkynol,
日本薬学会第138年会, Mar. 2018.
23. Inriki Wan, Akiho Yamauchi, Tsubasa Inokuma, 山岡 庸介, 高須 清誠 and Ken-ichi Yamada :
Kinetic Resolution of -Hydroxy Thioamides Based on Chiral Recognition of Substrate-Cocatalyst Complex,
日本薬学会第138年会, Mar. 2018.
24. Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui :
DAO分子表面に結合する阻害分子の計算科学的解析,
2017年度生命科学系学会合同年次大会, Dec. 2017.
25. Tsubasa Inokuma, Li Yin Wang, Yamaoka Yousuke, Takasu Kiyosei and Ken-ichi Yamada :
キラルNHC触媒を用いたα-ヒドロキシカルボン酸誘導体の速度論的光学分割,
第10回有機触媒シンポジウム, Dec. 2017.
26. Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis,
第54回ペプチド討論会, Nov. 2017.
27. Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka :
Development of methodology for producing thioesters from naturally occurring peptide sequence,
第54回ペプチド討論会, Nov. 2017.
28. Inriki Wan, Tsubasa Inokuma, 山岡 庸介, 高須 清誠 and Ken-ichi Yamada :
キラルNHC触媒を用いる不斉アシル化によるα-ヒドロキシカルボン酸誘導体の速度論的光学分割,
第43回反応と合成の進歩シンポジウム, Nov. 2017.
29. Chiaki Komiya, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質C末端特異的活性化反応の開発,
第35回メディシナルケミストリーシンポジウム, Oct. 2017.
30. Takahisa Jichu, Keisuke Aihara, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発,
第35回メディシナルケミストリーシンポジウム, Oct. 2017.
31. Tsubasa Inokuma :
ペプチドへの直接的不斉反応を基盤とした非天然アミノ酸含有ペプチドの新規効率的不斉合成法開発,
第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2017.
32. Kentarou Hashimoto, Yinli Wang, Satoru Kuwano, Kiyosei Takasu, Tsubasa Inokuma and Ken-ichi Yamada :
遠隔位チューニングによるキラルNHC触媒の高性能化,
第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2017.
33. Akiho Yamauchi, Yasunori Miyakawa, Yinli Wang, Tsubasa Inokuma, Kiyosei Takasu and Ken-ichi Yamada :
スルホニルアルキノールの転位環化反応のキラルカウンターカチオンを用いる触媒的不斉化,
第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2017.
34. Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka :
N-Sアシル基転移を基盤としたタンパク質ラベル化法を用いたD-アミノ酸酸化酵素阻害剤の結合サイト解明研究,
第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Oct. 2017.
35. Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質位置選択的修飾を目指したチオエステル調製法の開発,
第49回若手ペプチド夏の勉強会, Aug. 2017.
36. Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ペプチドへの直接的不斉反応を基盤とする非天然アミノ酸含有ペプチドの新規効率的合成法の開発,
第49回若手ペプチド夏の勉強会, Aug. 2017.
37. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移反応の速度差を利用したライゲーション反応のための新規補助基の開発,
第49回若手ペプチド夏の勉強会, Aug. 2017.
38. Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ペプチド創薬を指向した非天然アミノ酸含有ペプチドの新規効率的合成法の開発,
創薬懇話会2017 in 加賀, Jul. 2017.
39. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質化学合成のための新規N-ペプチジルアニリド型補助基の開発,
創薬懇話会2017 in 加賀, Jul. 2017.
40. Yamauchi Akiho, Miyakawa Yasunori, Yinli Wang, Takasu Kiyosei, Tsubasa Inokuma and Ken-ichi Yamada :
スルホニルアルキノールの転位環化反応のキラルカウンターカチオンを用いる触媒的不斉化,
創薬懇話会2017 in 加賀, Jul. 2017.
41. Tsubasa Inokuma, Nishida Koudai, Akira Shigenaga and Akira Otaka :
ペプチドへの直接的不斉反応を基盤とする新規非天然アミノ酸含有ペプチド合成テクノロジーの開発,
日本薬学会第137年会, Mar. 2017.
42. Kohdai Nishida, Takahisa Jichu, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
MnO2を用いたα-イミノカルボン酸誘導体の効率的合成法の開発,
日本薬学会第137年会, Mar. 2017.
43. Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発,
日本薬学会第137年会, Mar. 2017.
44. Taiki Kohiki, Masaya Denda, 藤川 昴樹, Tsubasa Inokuma, Akira Shigenaga, Kentaro Kogure and Akira Otaka :
N-Sulfanylethylanilideを用いた細胞内標的タンパク質ラベル化法の開発,
日本薬学会第137年会, Mar. 2017.
45. Kyohei Morimoto, 山次 建三, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga, 金井 求 and Akira Otaka :
DMAP誘導体を用いた環状ペプチド合成法の開発,
日本薬学会第137年会, Mar. 2017.
46. Naoto Naruse, 津田 修吾, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
効率的タンパク質合成のためのSEAlideペプチドを用いたon-resinチオエステル化法の開発,
日本薬学会第137年会, Mar. 2017.
47. Tsubasa Inokuma :
ペプチドへの直接的不斉反応を基盤とする新規非天然アミノ酸含有ペプチド合成法の開発,
平成28年度特別経費事業合同シンポジウム(創薬人育成のための創薬実践道場教育構築事業)(多機能性人工エキソソーム(iTEX)医薬品化実践を通じた操薬人育成事業), Feb. 2017.
48. Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
タンパク質位置選択的修飾を指向したチオエステル調製法の開発,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
49. Naoto Naruse, 種子島 幸祐, Kouhei Tsuji, Tsubasa Inokuma, Akira Shigenaga, 原 孝彦 and Akira Otaka :
N-Sulfanylethylanilideペプチドを利用したケモカイン誘導体の合成とToll-like receptor 9の活性化への影響について,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
50. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
SEAlideを基盤とした標的タンパク質精製ツールの開発研究,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
51. 伊藤 幸裕, Keisuke Aihara, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, Akira Shigenaga, Tsubasa Inokuma, 中川 秀彦, 宮田 直樹, 水上 民夫, Akira Otaka and 鈴木 孝禎 :
ヒドラジン構造を持つペプチド性LSD1阻害薬の創製,
第34回メディシナルケミストリーシンポジウム, Dec. 2016.
52. Naoto Naruse, Mitsuhiro Etoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylcoumarinylamide (SECmide) を利用したN-Sアシル転移促進剤の探 索とペプチド合成への応用,
第42回反応と合成の進歩シンポジウム, Nov. 2016.
53. Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
非天然アミノ酸含有ペプチドの新規効率的合成法の開発,
第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016.
54. Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
マンノース6リン酸修飾型GM2活性化タンパク質の合成研究,
第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016.
55. Keisuke Aihara, Takahisa Jichu, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ケミカルバイオロジー研究を指向した環状ペプチドtrichamideの合成研究,
第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016.
56. 伊藤 幸裕, Keisuke Aihara, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, Akira Shigenaga, Tsubasa Inokuma, 中川 秀彦, 宮田 直樹, 水上 民夫, Akira Otaka and 鈴木 孝禎 :
Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors,
第53回ペプチド討論会, Oct. 2016.
57. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
One-pot sequential native chemical ligations using photocaged crypto-thioester,
第53回ペプチド討論会, Oct. 2016.
58. Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
Development of N-sulfanylethylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins,
第53回ペプチド討論会, Oct. 2016.
59. Takahisa Jichu, Keisuke Aihara, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Synthetic study of trichamide using Cys-free ligation,
第53回ペプチド討論会, Oct. 2016.
60. Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka :
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library,
第53回ペプチド討論会, Oct. 2016.
61. Takahisa Jichu, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka :
Cys-free ligationを用いた環状ペプチドTrichamideの合成研究,
第48回若手ペプチド夏の勉強会, Aug. 2016.
62. Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
リソソーム移行型GM2活性化タンパク質の合成研究,
第48回若手ペプチド夏の勉強会, Aug. 2016.
63. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究,
創薬懇話会2016 in 蓼科, Jun. 2016.
64. Takahisa Jichu, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka :
中分子創薬を指向した環状ペプチドTrichamideの合成研究,
創薬懇話会2016 in 蓼科, Jun. 2016.
65. Taiki Kohiki, Masaya Denda, Takuya Morisaki, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
''SEAL-tag''を基盤とした細胞内での標的タンパク質ラベル化法の開発,
日本ケミカルバイオロジー学会第11回年会, Jun. 2016.
66. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
標的タンパク質精製ツール"SEAlide-based traceable linker"の開発,
日本ケミカルバイオロジー学会第11回年会, Jun. 2016.
67. Takahisa Jichu, Keisuke Aihara, Mitsuhiro Etoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
環状ペプチドTrichamideの合成研究,
日本薬学会第136年会, Mar. 2016.
68. Mitsuhiro Etoh, Kyohei Morimoto, Kouhei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チオエステル等価体としてのN-sulfanylethylcoumarinylamide (SECmide) の開発及びペプチド合成への応用,
日本薬学会第136年会, Mar. 2016.
69. Takuya Morisaki, Masaya Denda, Takahiro Nakamura, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka :
標的タンパク質の高効率的同定を可能とする新規リンカー分子の開発研究,
日本薬学会第136年会, Mar. 2016.
70. Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
マンノース六リン酸修飾型GM2活性化タンパク質の合成研究,
日本薬学会第136年会, Mar. 2016.
71. Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答型チオエステル等価体を用いたOne-potタンパク質化学合成法の開発,
日本薬学会第136年会, Mar. 2016.
72. Tsubasa Inokuma :
炭素-窒素結合の穏和な酸化反応を利用した非天然アミノ酸新規効率的合成法の開発,
平成27年度特別経費事業合同シンポジウム(創薬人育成のための創薬実践道場教育構築事業)(多機能性人工エキソソーム(iTEX)医薬品化実践を通じた操薬人育成事業)), Feb. 2016.
73. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Development of intein-inspired peptide bond processing device,
第52回ペプチド討論会, Nov. 2015.
74. Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol,
第52回ペプチド討論会, Nov. 2015.
75. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Kensuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka :
SEAlideを利用した標的タンパク質精製ツール ''トレーサブルリンカー''の開発研究,
第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015.
76. Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
多成分縮合を可能とする光応答型チオエステル等価体の開発,
第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015.
77. Tsubasa Inokuma, Kazuya Iwamoto, Ken Sakamoto, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylanilide (SEAlide)を基盤としたタンパク質-ペプチドコンジュゲーション法の開発,
第41回反応と合成の進歩シンポジウム, Oct. 2015.
78. Takahisa Jichu, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
α-イミノカルボン酸誘導体の効率的合成法の開発と非天然α-アミノ酸合成への応用,
第41回反応と合成の進歩シンポジウム, Oct. 2015.
79. Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka :
非天然型アミノ酸を含むタンパク質の調製を志向したタンパク質完全化学合成法の開拓,
第64回高分子討論会(特定テーマ 融合マテリアルの精密構造制御と機能創製), Sep. 2015.
80. Takahisa Jichu, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
チアゾール含有環状ペプチドTrichamideの合成研究,
第三十一回若手化学者のための化学道場, Aug. 2015.
81. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質自己編集システムを範としたアミド結合切断反応の開発,
第三十一回若手化学者のための化学道場, Aug. 2015.
82. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Kensuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka :
標的タンパク質の効率的精製および選択的ラベル化を可能とするケミカルツールの開発研究,
第三十一回若手化学者のための化学道場, Aug. 2015.
83. Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答型チオエステル等価体を利用した多成分One-pot NCL法の開発,
第三十一回若手化学者のための化学道場, Aug. 2015.
84. Masaya Denda, Takuya Morisaki, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移反応を基盤としたin cellタンパク質ラベル化法の開発,
第47回若手ペプチド夏の勉強会, Aug. 2015.
85. Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Keisuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka :
標的タンパク質の高効率同定を可能とするケミカルツールの開発研究,
第47回若手ペプチド夏の勉強会, Aug. 2015.
86. Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
光応答性補助基を用いた4成分One-pot NCL法の開発,
第47回若手ペプチド夏の勉強会, Aug. 2015.
87. Masaya Denda, Takuya Morisaki, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka :
N-Sアシル基転移反応を利用した新規ラベル化試薬の開発,
創薬懇話会2015 in 徳島, Jul. 2015.
88. Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
タンパク質半化学合成を指向した配列特異的チオエステル化法の開発,
創薬懇話会2015 in 徳島, Jul. 2015.
89. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Tsubasa Inokuma and Akira Otaka :
GM2活性化タンパク質誘導体の第二世代化学合成法の確立,
日本ケミカルバイオロジー学会第10回年会, Jun. 2015.
90. Kimihito Naruse, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
M6P修飾型GM2APの合成検討,
日本薬学会第135年会, Mar. 2015.
91. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究,
日本薬学会第135年会, Mar. 2015.
92. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka :
GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究,
日本薬学会第135年会, Mar. 2015.
93. Miku Kita, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Protein trans-splicingの高速化を指向したN-intein合成法の開発研究,
日本薬学会第135年会, Mar. 2015.
94. Koji Ebisuno, Masaya Denda, Keiji Ogura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価,
第40回反応と合成の進歩シンポジウム, Nov. 2014.
95. Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka :
固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発,
第40回反応と合成の進歩シンポジウム, Nov. 2014.
96. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質機能制御を指向したプロテインスプライシング模倣型アミド結合切断反応の開発,
第40回反応と合成の進歩シンポジウム, Nov. 2014.
97. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kouhei Satou, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
新規タンパク質チオエステル調製法の開発,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
98. Takahiro Nakamura, Akira Shigenaga, Kouhei Satou, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka :
GM2活性化タンパク質アナログの第二世代化学合成法の開発研究,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
99. Mitsuhiro Etoh, Masaya Denda, Kouhei Satou, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
ペプチドチオエステル調製のためのクマリン型補助基の開発,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014.
100. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
Preparation of Peptide/protein Thioesters Using a Chemical Protocol Applicable to Expressed Proteins.,
51th The Japanese Peptide Society, Oct. 2014.
101. Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
Preparation of peptide thioesters using N-sulfanylethylcoumarinylamide peptide,
第51回ペプチド討論会, Oct. 2014.
102. Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka :
One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide,
第51回ペプチド討論会, Oct. 2014.
103. Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka :
Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein,
51th The Japanese Peptide Society, Oct. 2014.
104. Kohei Tsuji, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka :
二量体化したCXCL14 C端側領域はCXCL12アンタゴニストとなる,
第46回若手ペプチド夏の勉強会, Aug. 2014.
105. Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Takahiro Nakamura, Tsubasa Inokuma and Akira Otaka :
新規タンパク質チオエステル調製法 ''SQAT system'' の開発,
第46回若手ペプチド夏の勉強会, Aug. 2014.
106. Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka :
第二世代hGM2AP完全化学合成法の開発研究,
第46回若手ペプチド夏の勉強会, Aug. 2014.
107. Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylcoumarinylamide (SECmide) を用いたペプチドチオエステル調製法の開発,
第46回若手ペプチド夏の勉強会, Aug. 2014.
108. Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
アスパラギン誘導体を用いたインテイン模倣型ペプチド結合切断システムの開発,
第46回若手ペプチド夏の勉強会, Aug. 2014.
109. Rin Miyajima, Yusuke Tsuda, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
天然型アミノ酸配列からのチオエステル合成,
第46回若手ペプチド夏の勉強会, Aug. 2014.
110. Takuya Morisaki, Jun Yamamoto, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka :
SEAlideを基盤としたトレーサブルリンカーの開発研究,
第46回若手ペプチド夏の勉強会, Aug. 2014.
111. Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka :
オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発,
創薬懇話会2014, Jul. 2014.
112. Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発,
日本ケミカルバイオロジー学会第9回年会, Jun. 2014.
113. Ysuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka :
発現タンパク質に適用可能な新規タンパク質チオエステル合成法の開発,
日本薬学会第134年会, Mar. 2014.
114. Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
N-Sulfanylethylcoumarinylamide (SECmide) を用いたペプチドチオエステル調製法の開発,
日本薬学会第134年会, Mar. 2014.
115. Chiaki Komiya, Jun Yamamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
還元的N-N結合切断反応の改良を基盤とした刺激応答型アミノ酸の実用的合成法の検討,
日本薬学会第134年会, Mar. 2014.
116. Rin Miyajima, Yusuke Tsuda, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
天然アミノ酸配列に適用可能な新規ペプチドチオエステル合成法の開発,
日本薬学会第134年会, Mar. 2014.
117. Takuya Morisaki, Jun Yamamoto, Akira Shigenaga, Youichi Sato, Tsubasa Inokuma, Aiko Yamauchi and Akira Otaka :
標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発,
日本薬学会第134年会, Mar. 2014.

Et cetera, Workshop:

1. Kazuya Iwamoto, Tsubasa Inokuma, Ken Sakamoto, Kohei Sato, Akira Shigenaga and Akira Otaka :
NCL法を利用したペプチド–タンパク質コンジュゲーション法の開発研究,
第6回夏の生物系勉強会, Aug. 2015.
2. Chiaki Komiya, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka :
タンパク質機能の時空間的制御を指向したペプチド結合切断能を有する刺激応答型アミノ酸の開発,
文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第10回 若手スクール, May 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • アリールグリシン不斉構築と非天然アミノ酸含有ペプチド効率的合成への展開 (Project/Area Number: 18K14869 )
  • Novel methodology for the synthesis of unnatural amino acid-containing peptide based on asymmetric construction of indolyl glycine (Project/Area Number: 16K18845 )
  • Development of a stimulus-responsive amino acid that enables functional control of peptides and proteins (Project/Area Number: 15K07858 )
  • Development of Highly Practical Process of Organic Synthesis by using Asymmetric Organocatalysts (Project/Area Number: 21890112 )
  • Search by Researcher Number (40541272)