徳島大学 / 教育研究者総覧 --- 山本由理

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徳島大学 ⟩ 病院 ⟩ 先端医科医療開発研究プロジェクト ⟩
徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 小児·周産·女性科 ⟩ 産科婦人科 ⟩
徳島大学 ⟩ 医学部 ⟩ 医学科 ⟩ 発生発達医学講座 ⟩ 産科婦人科学分野 ⟩

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研究活動

専門分野

研究テーマ

著書・論文

著書:

1.	岩佐武, 湊沙希, 山本由理 : 多嚢胞性卵巣症候群(PCOS), 総合医学社, 2021年9月.

学術論文(審査論文):

1.	湊沙希, 山本由理, 野口拓樹, 内芝舞実, 鎌田周平, 谷口友香, 河北貴子, 苛原稔, 岩佐武 : 当院における精巣内精子採取術・顕微授精(testicular sperm extraction-intracytoplasmic sperm injection: TESE-ICSI)の治療成績と周産期予後の検討, 現代産婦人科, Vol.71, 93-98, 2022年.
2.	Shuhei Kamada, Yuri Yamamoto, Hidenori Aoki, Kou Tamura, Asuka Takeda, Saki Minato, Rie Masaki, Rie Yanagihara, Noriko Hayashi, Yuya Yano, Junki Imaizumi, Tomohiro Kagawa, Atsuko Yoshida, Takako Kawakita, Minoru Irahara and Takeshi Iwasa : A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes., Reproductive Medicine and Biology, Vol.21, No.1, e12416, 2021. (要約) Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models. We tried to produce an improved rat model of PCOS, and the reproductive, metabolic, and behavioral phenotypes of the model rats were evaluated. Female rats were implanted with silicon tubes containing oil-dissolved dihydrotestosterone (Oil-DHT) as a new PCOS model. Their phenotypes were compared with those of conventional PCOS model rats (DHT), into which tubes containing crystalline DHT were implanted, and non-DHT-treated rats (control). Both the Oil-DHT and DHT rats showed greater body weight gain, food intake, and fat depot weight than the control rats. Furthermore, these groups showed fewer estrous stages and increased numbers of cystic follicles. The DHT rats exhibited lower ovarian and uterine weights than the control rats, whereas no such changes were observed in the Oil-DHT rats. The Oil-DHT and DHT rats showed less locomotor activity in the light phase than the control rats. Our proposed PCOS model reproduced both the reproductive and metabolic phenotypes of PCOS and may have potential for PCOS research. (徳島大学機関リポジトリ) ● Metadata: 117712 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/rmb2.12416 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34934399 ● Search Scopus @ Elsevier (PMID): 34934399 ● Search Scopus @ Elsevier (DOI): 10.1002/rmb2.12416 (徳島大学機関リポジトリ: 117712, DOI: 10.1002/rmb2.12416, PubMed: 34934399)
3.	Takeshi Iwasa, Toshiya Matsuzaki, Yiliyasi Mayila, Rie Yanagihara, Yuri Yamamoto, Takako Kawakita, Akira Kuwahara and Minoru Irahara : Oxytocin treatment reduced food intake and body fat and ameliorated obesity in ovariectomized female rats., Neuropeptides, Vol.75, 49-57, 2019. (要約) Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabolic disorders, no safe medical interventions for these conditions have been established. In this study, we evaluated the effects of oxytocin on appetite, body weight, and fat mass in ovariectomized rats. Six-day oxytocin treatment attenuated cumulative food intake and body weight gain, and reduced visceral and subcutaneous fat weight and adipocyte cell area in ovariectomized rats. Blood examinations indicated that 6-day oxytocin treatment did not alter renal or hepatic functions. Instead, it might prevent ovariectomy-induced liver damage. In addition, acute oxytocin treatment did not affect body temperature or locomotor activity. These results indicate that oxytocin might be useful for treating or preventing menopause-induced metabolic disorders, without causing any adverse effects. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.npep.2019.03.002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30885500 ● Search Scopus @ Elsevier (PMID): 30885500 ● Search Scopus @ Elsevier (DOI): 10.1016/j.npep.2019.03.002 (DOI: 10.1016/j.npep.2019.03.002, PubMed: 30885500)
4.	岩佐武, 谷口友香, 中山聡一朗, 米谷直人, 吉田あつ子, 阿部彰子, 山本由理, 加地剛, 桑原章, 松崎利也, 苛原稔 : 徳島大学病院産科婦人科における不育症患者に対する染色体検査の実施状況, 現代産婦人科, Vol.67, No.1, 21-24, 2018年. (キーワード) 不育症 / 習慣流産 / 染色体検査 / recurrent miscarriage / chromosome analysis (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520572359817582976 (CiNii: 1520572359817582976)
5.	Yuka Taniguchi, Akira Kuwahara, Ayaka Tachibana, Yuya Yano, Kiyohito Yano, Yuri Yamamoto, Mikio Yamasaki, Takeshi Iwasa, Kenji Hinokio, Toshiya Matsuzaki and Minoru Irahara : Intra-follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology., Reproductive Medicine and Biology, Vol.16, No.4, 380-385, 2017. (要約) To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology. Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology. The follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick-up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology. Kisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation. (徳島大学機関リポジトリ) ● Metadata: 112881 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/rmb2.12056 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29259492 ● Search Scopus @ Elsevier (PMID): 29259492 ● Search Scopus @ Elsevier (DOI): 10.1002/rmb2.12056 (徳島大学機関リポジトリ: 112881, DOI: 10.1002/rmb2.12056, PubMed: 29259492)
6.	Mikio Yamasaki, Akira Kuwahara, Takeshi Iwasa, Yuri Yamamoto, Yuka Taniguchi, Yuya Yano, Sumika Matsui, Toshiya Matsuzaki and Minoru Irahara : Development-related changes in the expression of the ovarian Kiss1 and Kiss1r genes and their sensitivity to human chorionic gonadotropin in prepubertal female rats., The Journal of Reproduction and Development, Vol.63, No.4, 409-414, 2017. (要約) Kisspeptin, which is encoded by the Kiss1 gene, and its receptor, the G protein-coupled receptor 54 (Kiss1r), play important roles in the regulation of reproductive functions in mammals. Several studies have shown that the Kiss1 and Kiss1r genes are expressed in the rat, primate, and human ovaries, and that the ovarian kisspeptin system plays a pivotal role in ovulation at the proestrous stage in adulthood. The purpose of this study was to evaluate development-related changes in the expression of ovarian Kiss1 and Kiss1r genes and in kisspeptin levels, and to identify the regulatory factors for these genes during the prepubertal period. The serum kisspeptin level was also measured to examine whether ovarian kisspeptin affects serum kisspeptin levels. Variations in the ovarian Kiss1 and Kiss1r mRNA levels were observed during the prepubertal period in female rats, with levels peaking around postnatal days 20 and 15, respectively. Nevertheless, the ovarian kisspeptin content per total protein level was stably maintained. Serum kisspeptin levels at postnatal days 30 and 35 were higher than those at earlier postnatal days. The pattern of the ovarian Kiss1 mRNA levels was similar to that of the serum luteinizing hormone (LH) levels, and the ovarian Kiss1 mRNA level increased after injection with human chorionic gonadotropin (HCG) on postnatal day 20, but not on postnatal days 10 and 30. These data indicate that ovarian Kiss1 and Kiss1r mRNA levels are increased on postnatal days 20 and 15, respectively, and that changes in the serum LH level and the ovarian sensitivity to LH may be involved in the alteration of ovarian Kiss1 mRNA levels. (キーワード) Animals / Chorionic Gonadotropin / Female / Gene Expression Regulation, Developmental / Kisspeptins / Ovary / Rats / Rats, Sprague-Dawley / Receptors, Kisspeptin-1 (徳島大学機関リポジトリ) ● Metadata: 112975 (出版サイトへのリンク) ● Publication site (DOI): 10.1262/jrd.2016-179 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28552864 ● Search Scopus @ Elsevier (PMID): 28552864 ● Search Scopus @ Elsevier (DOI): 10.1262/jrd.2016-179 (徳島大学機関リポジトリ: 112975, DOI: 10.1262/jrd.2016-179, PubMed: 28552864)
7.	Yuu Tanaka, Akira Kuwahara, Kenjiro Ushigoe, Yuya Yano, Yuka Taniguchi, Yuri Yamamoto, Toshiya Matsuzaki, Toshiyuki Yasui and Minoru Irahara : Expression of cytokine-induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis., Reproductive Medicine and Biology, Vol.16, No.2, 157-165, 2017. (要約) Cytokine-induced neutrophil chemoattractant (CINC/gro) is a CXC family chemokine, similar to interleukin-8 in rats, and is one of the factors that regulates ovulation. However, the mechanism that regulates atresia of the ovaries postovulation is not clearly defined. Whether antibody-blocking of CINC/gro can alter the number of ovulated oocytes and modulate neutrophil infiltration was investigated. The effect of the antibody on the level of inflammatory cytokine production and follicular atresia was examined. Apoptosis was measured by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and via analysis of the messenger RNA expression of Bcl-2 and Bcl2-associated X (Bax). The anti-CINC/gro antibody treatment decreased the number of ovulated oocytes. The messenger RNA levels of cyclooxygenase-2 and interleukin-1 beta were decreased by the antibody treatment, whereas that of tumor necrosis factor (TNF) alpha was increased. The TUNEL analysis revealed a larger number of apoptotic cells in the antibody group, compared with those in the control group, as well as a significant increase in the Bax/Bcl-2 ratio 24 hours after human chorionic gonadotropin administration. These findings suggest that ovulation is accelerated by neutrophil infiltration into the theca layer. The CINC/gro appears to synergize with interleukin-1 beta for ovulation. By contrast, the data suggest that CINC/gro expression suppresses TNF alpha expression and that CINC/gro expression therefore prevents the follicles from undergoing atresia and apoptosis. (徳島大学機関リポジトリ) ● Metadata: 113212 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/rmb2.12022 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29259464 ● Search Scopus @ Elsevier (PMID): 29259464 ● Search Scopus @ Elsevier (DOI): 10.1002/rmb2.12022 (徳島大学機関リポジトリ: 113212, DOI: 10.1002/rmb2.12022, PubMed: 29259464)
8.	吉田加奈子, 加藤剛志, 山本由理, 田中優, 苛原稔 : 骨盤内膿瘍に対する腹腔鏡手術の有用性, 現代産婦人科, Vol.59, No.1, 59-63, 2010年. (要約) 骨盤内膿瘍に対する治療は，抗生剤による薬物療法が主体であるが，抗生剤無効例や，消化管から発生した膿瘍との鑑別を要する症例では外科的アプローチが必要となる．骨盤内膿瘍の場合，炎症による癒着が強いことが多く，手術は比較的難易度が高い．しかし，高度の炎症で疲弊した患者の負担を軽減するために，近年では腹腔鏡手術が積極的に導入されており，当院でも可能な限り腹腔鏡手術で対応している．抗生剤による治療が無効であった付属器膿瘍に対して腹腔鏡下手術を施行した4症例について報告する．4例とも輸血を要するような出血はなく，また他臓器損傷もなかった．術後は，速やかに炎症所見が改善し特に問題なく経過した．骨盤内膿瘍に対する腹腔鏡手術は，ドレナージによりすみやかな炎症軽減が可能であり，かつ低侵襲であることから有用性は高い．一方で，(汎発性腹膜炎などで，)腸管麻痺を伴う症例では，腸管の膨隆のため腹腔鏡下の視野確保が困難であり，腹腔鏡手術の適応は慎重であるべきであると考える． (キーワード) 付属器膿瘍 / 腹腔鏡 / tubo-ovaruan abscess / laparoscopic surgery (徳島大学機関リポジトリ) ● Metadata: 113614 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282813437686400 (徳島大学機関リポジトリ: 113614, CiNii: 1050282813437686400)

学術論文(紀要・その他):

1.	田村公, 山本由理, 湊沙希, 柳原里江, 鎌田周平, 谷口友香, 阿部彰子, 西村正人, 苛原稔, 岩佐武 : 子宮内膜癌・子宮内膜異型増殖症に対する妊孕性温存治療の治療効果と妊娠成績，周産期予後, 現代産婦人科, Vol.70, No.1, 123-128, 2021年. (キーワード) 子宮内膜癌 / 子宮内膜異型増殖症 / MPA療法 / 妊孕性温存 / endometrial cancer / atypical endometrial hyperplasia / medroxyprogesterone acetate (MPA) treatment / シキュウナイマクガン / シキュウナイマクイケイゾウショクショウ / MPA リョウホウ / ニンヨウセイオンゾン (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520853835559930496 (CiNii: 1520853835559930496)

総説・解説:

1.	岩佐武, 野口拓樹, 内芝舞実, 山本由理 : 多胎二卵性, 一卵性多胎, 臨床婦人科産科, Vol.76, No.11, 1112-1117, 2022年11月.
2.	岩佐武, 内芝舞実, 野口拓樹, 山本由理 : 黄体ホルモン製剤の種類と使い方, 産婦人科の実際, Vol.71, No.10, 1277-1280, 2022年9月.
3.	岩佐武, 野口拓樹, 山本由理 : 黄体ホルモンと生殖補助医療, 産科と婦人科, Vol.89, No.9, 963-967, 2022年8月.
4.	岩佐武, 湊沙希, 山本由理 : 新鮮胚移植と凍結胚移植の安全性, 臨床婦人科産科, Vol.764, No.4, 122-125, 2022年4月.
5.	岩佐武, 柳原里江, 山本由理 : 卵巣老化とPGT-A, 産科と婦人科, Vol.88, No.8, 952-957, 2021年8月.
6.	岩佐武, 柳原里江, 山本由理 : 【画像! エキスパート直伝産婦人科画像診断】生殖内分泌 .機能性囊胞, 黄体囊胞, 排卵・黄体,卵巣出血, 産科と婦人科, Vol.88, No.Suppl, 255-258, 2021年3月.
7.	岩佐武, 鎌田周平, 山本由理 : 耐糖能異常, 産婦人科の実際, Vol.69, No.13, 1593-1596, 2020年12月.
8.	岩佐武, 山本由理, 桑原章 : がん治療後の内分泌環境の変化, 日本がん·生殖医療学会誌, Vol.3, No.1, 202-204, 2020年2月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669555939849344 (CiNii: 1523669555939849344)
9.	Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Yuri Yamamoto, Akira Kuwahara and Minoru Irahara : Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms., Journal of Clinical Medicine, Vol.7, No.7, Jul. 2018. (要約) It is known that metabolic disturbances suppress reproductive functions in females. The mechanisms underlying metabolic and nutritional effects on reproductive functions have been established based on a large body of clinical and experimental data. From the 1980s to 1990s, it was revealed that disrupted gonadotropin-releasing hormone (GnRH) secretion is the main cause of reproductive impairments in metabolic and nutritional disorders. From the late 1990s to early 2000s, it was demonstrated that, in addition to their primary functions, some appetite- or metabolism-regulating factors affect GnRH secretion. Furthermore, in the early 2000s, kisspeptin, which is a potent positive regulator of GnRH secretion, was newly discovered, and it has been revealed that kisspeptin integrates the effects of metabolic status on GnRH neurons. Recent studies have shown that kisspeptin mediates at least some of the effects of appetite- and metabolism-regulating factors on GnRH neurons. Thus, kisspeptin might be a useful clinical target for treatments aimed at restoring reproductive functions in individuals with metabolic or nutritional disturbances, such as those who exercise excessively, experience marked weight loss, or suffer from eating disorders. This paper presents a review of what is currently known about the effects of metabolic status on reproductive functions and their underlying mechanisms by summarizing the available evidence. (徳島大学機関リポジトリ) ● Metadata: 117743 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/jcm7070166 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29976877 ● Search Scopus @ Elsevier (PMID): 29976877 ● Search Scopus @ Elsevier (DOI): 10.3390/jcm7070166 (徳島大学機関リポジトリ: 117743, DOI: 10.3390/jcm7070166, PubMed: 29976877)

国際会議:

1.	YAMASAKI Mikio, Akira Kuwahara, TANIGUCHI Yuka, Yuri Yamamoto, Takeshi Iwasa, HINOKIO Kenji, Toshiya Matsuzaki and Minoru Irahara : Comparison of AMH and FSH an indicator of ovarian reserve in ART., IFFS/JSRM International Meeting,2015, Yokohama, Apr. 2015.
2.	TANAKA Yu, Akira Kuwahara, USHIGOE Kenjiro, YANO Yuya, TANIGUCHI Yuka, Yuri Yamamoto and Toshiya Matsuzaki : The role of CINC/gro in the rat ovulatory process., IFFS/JSRM International Meeting,2015, Yokohama, Apr. 2015.
3.	Yuri Yamamoto, Akira Kuwahara, YANO Yuya, TANIGUCHI Yuka, YAMASAKI MIkio, HINOKIO Kenji and Minoru Irahara : Clinical significance of serum hCG in early pregnancy periods in ART., IFFS/JSRM International Meeting,2015, Yokohama, Apr. 2015.
4.	Akira Kuwahara, HINOKIO Kenji, TANIGUCHI Yuka, Yuri Yamamoto, YAMASAKI Mikio, Takeshi Iwasa and Minoru Irahara : Clinical significance of estradiol and transvaginal ultrasonography for pregnancy outcomes in natural frozen-thawed blastcyst transfer cycles., IFFS/JSRM International Meeting,2015, Yokohama, Apr. 2015.
5.	Akiko Abe, Masato Nishimura, Eri Takiguchi, Takako Kawakita, TANIGUCHI Yuka, Yuri Yamamoto, YAMASAKI Mikio, Takeshi Iwasa, Akira Kuwahara, Toshiya Matsuzaki and Minoru Irahara : Survey on oncologist and gynecologist concerned with fertility for cancer survivors in reproductive age., IFFS/JSRM International Meeting,2015, Yokohama, Apr. 2015.
6.	Masato Nishimura, Eri Takiguchi, Takako Kawakita, Akiko Abe, TANIGUCHI Yuka, Yuri Yamamoto, YAMASAKI Mikio, Takeshi Iwasa, Akira Kuwahara, Toshiya Matsuzaki and Minoru Irahara : Efficacy and pregnant outcomes of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical endometrial hyperplasia in young women., IFFS/JSRM International Meeting,2015, Yokohama, Apr. 2015.

国内講演発表:

1.	吉田加奈子, 加藤剛志, 武田明日香, 新垣亮輔, 今泉絢貴, 香川智洋, 峯田あゆか, 河北貴子, 山本由理, 苛原稔, 岩佐武 : ワークショップ:効率よくTLH上達を目指すための当科での取り組み, 第62回日本産婦人科内視鏡学会, 2022年9月.
2.	山本由理, 加藤剛志 : 子宮腺筋症核出術後に不妊治療を行うも妊娠せず子宮全摘術をおこなった1例, 第60回日本産科婦人科内視鏡学会学術講演会, 2020年12月.
3.	清重尚希, 住谷龍平, 水口槙子, 中村昌史, 大浦雅博, 曽我部公子, 高橋真美子, 原田武志, 藤井志朗, 賀川久美子, 安倍正博, 中村信元, 三木浩和, 曽賀愛未, 一宮由貴, 山本由理 : 急性転化をきたしたAYA世代慢性骨髄性白血病の1例, 四国医学雑誌, Vol.76, No.5-6, 354-355, 2020年12月. (キーワード) 同種移植抗腫瘍剤(治療的利用) *白血病-BCR-ABL陽性慢性骨髄性(診断,治療,薬物療法) 急性転化(白血病) 障害者の子供造血幹細胞移植家族介護者ヒト青年期(13~18) 女
4.	山本由理, 桑原章, 阿部彰子, 岩佐武, 倉橋浩樹, 苛原稔 : 徳島大学病院における初めての着床前診断(PGT-M)の経験, 第72回日本産科婦人科学会学術集会, 2020年4月.
5.	阿部彰子, 岩佐武, 山本由理, 森本雅美, 中村信元, 桑原章 : 徳島県におけるがん生殖医療の現状と課題, 日本がん·生殖医療学会誌, Vol.3, No.1, 106, 2020年1月. (キーワード) 腫瘍地域社会ネットワーク徳島県 *妊孕性温存ヒト女
6.	岩佐武, 松崎利也, 阿部彰子, 柳原理江, 山本由理, 香川智洋, 峯田あゆか, 西村正人, 桑原章, 苛原稔 : 子宮内膜異型増殖症・初期子宮体癌患者に対する黄体ホルモン療法の治療成績，妊娠成績および周産期予後, 第72回中国四国日本産科婦人科学会学術講演会, 2019年9月.
7.	岩佐武, 山本由理, 阿部彰子, 桑原章, 西村正人, 松崎敏也, 苛原稔 : 子宮内膜異型増殖症・初期子宮体癌患者に対する黄体ホルモン療法の治療成績，妊娠成績および周産期予後, 第10回日本がん・生殖医療学会, 2019年2月.

その他・研究会:

1.	山本由理 : 徳島県におけるがん生殖ネットワーク形成の取り組み, 第35回徳島大学産科婦人科関連病院臨床検討会, 2021年9月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

女性においてアンドロゲンが栄養代謝機能に及ぼす影響とその機序に関する検討 (研究課題/領域番号: 21K09518 )
研究者番号（90622879）による検索