Tokushima University > Graduate School of Biomedical Sciences > 医学域 > Medical Science > Internal Medicine > Department of Medical Informatics >
Tokushima University > Faculty of Medicine > School of Medicine > Course of Integrated Brain Sciences > Medical Informatics >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1904013 AIを活用した食事摂取量自動判定による栄養管理システムの構築 >
Tokushima University > Graduate School of Medical Sciences > Medical Science > Course of Integrated Brain Sciences >
Tokushima University > Center for Design-Oriented AI Education and Research >
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Book / Paper

Academic Paper (Judged Full Paper):

1. Jun Hirose, Yoshifumi Wakata, Masato Tagi and Yuu Tamaki :
The role of medical informatics in the management of medical information,
The Journal of Medical Investigation : JMI, Vol.67, No.1,2, 27-29, 2020.
(DOI: 10.2152/jmi.67.27,   PubMed: 32378614,   Elsevier: Scopus)
2. Takeshi Konishi, Tadashi Kondo, Hiroki Moriguchi, Masato Tagi and Jun Hirose :
Accelerated organ region segmentation by the revised radial basis function network using a graphics processing unit.,
The Journal of Medical Investigation : JMI, Vol.66, No.1.2, 86-92, 2019.
(Tokushima University Institutional Repository: 113295,   DOI: 10.2152/jmi.66.86,   PubMed: 31064962)
3. Jun Hirose, H Nishioka, M Tsukano, S Matsubara, K Usuku and H Mizuta :
Matrix changes in articular cartilage in the knee of patients with rheumatoid arthritis after biological therapy: 1-year follow-up evaluation by T2 and T1ρ MRI quantification.,
Clinical Radiology, Vol.73, No.11, 984.e11-984.e18, 2018.
(DOI: 10.1016/j.crad.2018.06.020,   PubMed: 30072032)
4. Satoshi Hisanaga, Masato Miyake, Shusuke Taniuchi, Miho Oyadomari, Masatoshi Morimoto, Ryosuke Sato, Jun Hirose, Hiroshi Mizuta and Seiichi Oyadomari :
PERK-mediated translational control is required for collagen secretion in chondrocytes.,
Scientific Reports, Vol.8, No.1, 773, 2018.
(Tokushima University Institutional Repository: 112406,   DOI: 10.1038/s41598-017-19052-9,   PubMed: 29335505,   Elsevier: Scopus)
5. Jun Hirose, Nagata Takehiro, Ogushi Miki, Okamoto Nobukazu, Taniwaki Takuya, Oka Kiyoshi, Togami-Tomiguchi Wakana, Koga Hiroaki, Hayashi Kunio, Usuku Koichiro and Mizuta Hiroshi :
Validation of Each Category of Kihon Checklist for Assessing Physical Functioning, Nutrition and Cognitive Status in a Community-Dwelling Older Japanese Cohort,
Epidemiology : Current Research, Vol.7, No.5, 326-340, 2017.
(DOI: 10.4172/2161-1165.1000326)
6. H Nishioka, E Nakamura, Jun Hirose, N Okamoto, S Yamabe and H Mizuta :
MRI T1 and T2 mapping for the assessment of articular cartilage changes in patients with medial knee osteoarthritis after hemicallotasis osteotomy.,
Bone & Joint Research, Vol.5, No.7, 294-300, 2016.
(DOI: 10.1302/2046-3758.57.BJR-2016-0057.R1,   PubMed: 27421285)
7. Akira Yoshida, Hideaki Jinnouchi, Seigo Sugiyama, Jun Hirose, Tateki Segata, Kazue Furuta, Kazuhiro Katahira, Keizo Kajiwara, Kunio Hieshima, Tomio Jinnouchi and Koichiro Usuku :
Combined arteriosclerotic assessment of ankle-brachial index and maximum intima-media thickness via CCTA is useful for predicting coronary artery stenosis in patients with type 2 diabetes.,
Diabetes Research and Clinical Practice, Vol.117, 91-99, 2016.
(DOI: 10.1016/j.diabres.2016.04.013,   PubMed: 27329027)
8. Jun Hirose, Takuya Taniwaki, Toru Fujimoto, Tatsuya Okada, Takayuki Nakamura, Koichiro Usuku and Hiroshi Mizuta :
Validity of E-PASS System for Postoperative Morbidity of Spinal Surgery.,
Journal of Spinal Disorders & Techniques, Vol.28, No.10, E595-600, 2015.
(DOI: 10.1097/BSD.0000000000000056,   PubMed: 24270578)
9. Takehiro Nagata, Jun Hirose, Takayuki Nakamura, Takuya Tokunaga, Yusuke Uehara and Hiroshi Mizuta :
Evaluation of the utility of the Estimation of Physiologic Ability and Surgical Stress score for predicting post-operative morbidity after orthopaedic surgery.,
International Orthopaedics, Vol.39, No.11, 2167-2172, 2015.
(DOI: 10.1007/s00264-015-2993-2,   PubMed: 26399625)
10. Hiroaki Nishioka, Jun Hirose, Nobukazu Okamoto, Tatsuya Okada, Kiyoshi Oka, Takuya Taniwaki, Eiichi Nakamura, Yasuyuki Yamashita and Hiroshi Mizuta :
Evaluation of the relationship between T1 and T2 values and patella cartilage degeneration in patients of the same age group.,
European Journal of Radiology, Vol.84, No.3, 463-468, 2014.
(DOI: 10.1016/j.ejrad.2014.11.015,   PubMed: 25559169)
11. Y Uehara, Jun Hirose, S Yamabe, N Okamoto, T Okada, Seiichi Oyadomari and H Mizuta :
Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein.,
Osteoarthritis and Cartilage, Vol.22, No.7, 1007-1017, 2014.
(DOI: 10.1016/j.joca.2014.04.025,   PubMed: 24795271,   Elsevier: Scopus)
12. E Nakamura, N Okamoto, H Nishioka, T Karasugi, Jun Hirose and H Mizuta :
The long-term outcome of open-wedge osteotomy of the proximal tibia with hemicallotasis.,
The Bone & Joint Journal, Vol.96-B, No.4, 467-472, 2014.
(DOI: 10.1302/0301-620X.96B4.31345,   PubMed: 24692612)
13. Jun Hirose, Takuya Taniwaki, Toru Fujimoto, Tatsuya Okada, Takayuki Nakamura, Nobukazu Okamoto, Koichiro Usuku and Hiroshi Mizuta :
Predictive value of E-PASS and POSSUM systems for postoperative risk assessment of spinal surgery.,
Journal of Neurosurgery. Spine, Vol.20, No.1, 75-82, 2013.
(DOI: 10.3171/2013.9.SPINE12671,   PubMed: 24206035)
14. Jun Hirose, Hiroaki Nishioka, Nobukazu Okamoto, Yasunari Oniki, Eiichi Nakamura, Yasuyuki Yamashita, Koichiro Usuku and Hiroshi Mizuta :
Articular cartilage lesions increase early cartilage degeneration in knees treated by anterior cruciate ligament reconstruction: T1 mapping evaluation and 1-year follow-up.,
The American Journal of Sports Medicine, Vol.41, No.10, 2353-2361, 2013.
(DOI: 10.1177/0363546513496048,   PubMed: 23925576)
15. Hiroaki Nishioka, Jun Hirose, Eiichi Nakamura, Nobukazu Okamoto, Tatsuki Karasugi, Takuya Taniwaki, Tatsuya Okada, Yasuyuki Yamashita and Hiroshi Mizuta :
Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1 and T2 mapping.,
European Journal of Radiology, Vol.82, No.9, 1499-1505, 2013.
(DOI: 10.1016/j.ejrad.2013.04.038,   PubMed: 23743050)
16. Soichiro Yamabe, Jun Hirose, Yusuke Uehara, Tatsuya Okada, Nobukazu Okamoto, Kiyoshi Oka, Takuya Taniwaki and Hiroshi Mizuta :
Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes.,
The FEBS Journal, Vol.280, No.7, 1617-1629, 2013.
(DOI: 10.1111/febs.12170,   PubMed: 23374428)
17. Koji Takada, Jun Hirose, Soichiro Yamabe, Yushuke Uehara and Hiroshi Mizuta :
Endoplasmic reticulum stress mediates nitric oxide-induced chondrocyte apoptosis.,
Biomedical Reports, Vol.1, No.2, 315-319, 2013.
(DOI: 10.3892/br.2013.52,   PubMed: 24648941)
18. Jun Hirose, Hiroaki Nishioka, Eiichi Nakamura, Yasunari Oniki, Yasuyuki Yamashita and Hiroshi Mizuta :
T1 and T2 mapping of the proximal tibiofibular joint in relation to aging and cartilage degeneration.,
European Journal of Radiology, Vol.81, No.10, 2776-2782, 2011.
(DOI: 10.1016/j.ejrad.2011.11.019,   PubMed: 22153747)
19. Hiroaki Nishioka, Jun Hirose, Eiichi Nakamura, Yasunari Oniki, Koji Takada, Yasuyuki Yamashita and Hiroshi Mizuta :
T1 and T2 mapping reveal the in vivo extracellular matrix of articular cartilage.,
Journal of Magnetic Resonance Imaging : JMRI, Vol.35, No.1, 147-155, 2011.
(DOI: 10.1002/jmri.22811,   PubMed: 21990043)
20. Koji Takada, Jun Hirose, Kei Senba, Soichiro Yamabe, Yuichi Oike, Tomomi Gotoh and Hiroshi Mizuta :
Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage.,
International Journal of Experimental Pathology, Vol.92, No.4, 232-242, 2011.
(DOI: 10.1111/j.1365-2613.2010.00758.x,   PubMed: 21294793)
21. Hiroki Irie, Teiji Kato, Toshitake Yakushiji, Jun Hirose and Hiroshi Mizuta :
Painful heterotopic pacinian corpuscle in the hand: a report of three cases.,
Hand Surgery, Vol.16, No.1, 81-85, 2011.
(DOI: 10.1142/S0218810411005114,   PubMed: 21348037)
22. Jun Hirose, Soichiro Yamabe, Koji Takada, Nobukazu Okamoto, Ryoji Nagai and Hiroshi Mizuta :
Immunohistochemical distribution of advanced glycation end products (AGEs) in human osteoarthritic cartilage.,
Acta Histochemica, Vol.113, No.6, 613-618, 2010.
(DOI: 10.1016/j.acthis.2010.06.007,   PubMed: 20656335)
23. Shunsuke Mori, Jun Hirose and Kensuke Yonemura :
Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis.,
Clinical Rheumatology, Vol.29, No.12, 1357-1366, 2010.
(DOI: 10.1007/s10067-010-1454-y,   PubMed: 20383728)
24. Jun Hirose, Junji Ide, Toshitake Yakushiji, Yasuyuki Abe, Kimiaki Nishida, Satoshi Maeda, Yoshihisa Anraku, Koichiro Usuku and Hiroshi Mizuta :
Prediction of postoperative ambulatory status 1 year after hip fracture surgery.,
Archives of Physical Medicine and Rehabilitation, Vol.91, No.1, 67-72, 2010.
(DOI: 10.1016/j.apmr.2009.09.018,   PubMed: 20103398)
25. Jun Hirose, Junji Ide, Hiroki Irie, Kenshi Kikukawa and Hiroshi Mizuta :
New equations for predicting postoperative risk in patients with hip fracture.,
Clinical Orthopaedics and Related Research, Vol.467, No.12, 3327-3333, 2009.
(DOI: 10.1007/s11999-009-0915-6,   PubMed: 19495895)
26. Junji Ide, Kenshi Kikukawa, Jun Hirose, Ken-ichi Iyama, Hidetoshi Sakamoto and Hiroshi Mizuta :
The effects of fibroblast growth factor-2 on rotator cuff reconstruction with acellular dermal matrix grafts.,
Arthroscopy : the Journal of Arthroscopic & Related Surgery, Vol.25, No.6, 608-616, 2009.
(DOI: 10.1016/j.arthro.2008.11.011,   PubMed: 19501290)
27. Junji Ide, Kenshi Kikukawa, Jun Hirose, Ken-ichi Iyama, Hidetoshi Sakamoto, Toru Fujimoto and Hiroshi Mizuta :
The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon.,
Journal of Shoulder and Elbow Surgery, Vol.18, No.3, 391-398, 2009.
(DOI: 10.1016/j.jse.2009.01.013,   PubMed: 19393930)
28. Junji Ide, Kenshi Kikukawa, Jun Hirose, Ken-ichi Iyama, Hidetoshi Sakamoto and Hiroshi Mizuta :
Reconstruction of large rotator-cuff tears with acellular dermal matrix grafts in rats.,
Journal of Shoulder and Elbow Surgery, Vol.18, No.2, 288-295, 2008.
(DOI: 10.1016/j.jse.2008.09.004,   PubMed: 19058978)
29. Jun Hirose, Hiroshi Mizuta, Junji Ide, Eiichi Nakamura and Koji Takada :
E-PASS for predicting postoperative risk with hip fracture: a multicenter study.,
Clinical Orthopaedics and Related Research, Vol.466, No.11, 2833-2841, 2008.
(DOI: 10.1007/s11999-008-0377-2,   PubMed: 18663551)
30. Junji Ide, Akinari Tokiyoshi, Jun Hirose and Hiroshi Mizuta :
An anatomic study of the subscapularis insertion to the humerus: the subscapularis footprint.,
Arthroscopy : the Journal of Arthroscopic & Related Surgery, Vol.24, No.7, 749-753, 2008.
(DOI: 10.1016/j.arthro.2008.02.009,   PubMed: 18589262)
31. Jun Hirose, H Mizuta, J Ide and K Nomura :
Evaluation of estimation of physiologic ability and surgical stress (E-PASS) to predict the postoperative risk for hip fracture in elder patients.,
Archives of Orthopaedic and Trauma Surgery, Vol.128, No.12, 1447-1452, 2008.
(DOI: 10.1007/s00402-007-0551-0,   PubMed: 18175132)
32. Junji Ide, Akinari Tokiyoshi, Jun Hirose and Hiroshi Mizuta :
Arthroscopic repair of traumatic combined rotator cuff tears involving the subscapularis tendon.,
The Journal of Bone and Joint Surgery. American Volume, Vol.89, No.11, 2378-2388, 2007.
(DOI: 10.2106/JBJS.G.00082,   PubMed: 17974879)
33. I Ishii, H Mizuta, A Sei, Jun Hirose, S Kudo and Y Hiraki :
Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.,
The Journal of Bone and Joint Surgery. British Volume, Vol.89, No.5, 693-700, 2007.
(DOI: 10.1302/0301-620X.89B5.18450,   PubMed: 17540759)
34. Jun Hirose, M Lawrence Ryan and Ikuko Masuda :
Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease.,
Arthritis and Rheumatism, Vol.46, No.12, 3218-3229, 2002.
(DOI: 10.1002/art.10632,   PubMed: 12483726)
35. Jun Hirose, M Yamaga, T Kato, K Ikebe and K Takagi :
Effects of a hydroxyl radical scavenger, EPC-K1, and neutrophil depletion on reperfusion injury in rat skeletal muscle.,
Acta Orthopaedica Scandinavica, Vol.72, No.4, 404-410, 2001.
(DOI: 10.1080/000164701753542078,   PubMed: 11580130)
36. K Ikebe, T Kato, M Yamaga, Jun Hirose, T Tsuchida and K Takagi :
Increased ischemia-reperfusion blood flow impairs the skeletal muscle contractile function.,
The Journal of Surgical Research, Vol.99, No.1, 1-6, 2001.
(DOI: 10.1006/jsre.2001.6134,   PubMed: 11421597)
37. Jun Hirose, I Masuda and M L Ryan :
Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase parallels the production of extracellular inorganic pyrophosphate in response to growth factors and with aging.,
Arthritis and Rheumatism, Vol.43, No.12, 2703-2711, 2000.
(DOI: 10.1002/1529-0131(200012)43:12<2703::AID-ANR10>3.0.CO;2-Y,   PubMed: 11145028)
38. Jun Hirose, M Yamaga and K Takagi :
Reduced reperfusion injury in muscle. A comparison of the timing of EPC-K1 administration in rats.,
Acta Orthopaedica Scandinavica, Vol.70, No.2, 207-211, 1999.
(PubMed: 10366926)
39. Jun Hirose, Makio Yamaga, Junj Ide, Manab Tanoue and Katsumasa Takagi :
Reduced ischemia-reperfusion injury in muscle. Experiments in rats with EPC-K1, a new radical scavenger.,
Acta Orthopaedica Scandinavica, Vol.68, No.4, 369-373, 1997.
(DOI: 10.3109/17453679708996179,   PubMed: 9310042)

Review, Commentary:

1. Jun Hirose :
Role of medical informatics in future medical care,
Shikoku Acta Medica, Vol.75, No.1-2, 45-48, Apr. 2019.
(Tokushima University Institutional Repository: 113755,   CiNii: 120006729378)
2. Jun Hirose and H. Mizuta :
Crosstalk between Advanced Glycation and Endoplasmic Reticulum Stress in Cartilage Degeneration,
IMARS Highlights, Vol.8, No.6, 5-13, 2013.
3. Jun Hirose :
Clinical presentation and diagnosis of calcium deposition diseases (Review),
Int J Clin Rheumatol, Vol.5, No.1, 117-128, 2010.
4. Ikuko Masuda and Jun Hirose :
Animal models of pathologic calcification.,
Current Opinion in Rheumatology, Vol.14, No.3, 287-291, May 2002.
(PubMed: 11981328)

Proceeding of Domestic Conference:

1. Masato Tagi, Yuu Tamaki, Yoshifumi Wakata and Jun Hirose :
第39回 医療情報学連合大会, Nov. 2019.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @

  • 変形性関節症に対する小胞体ストレス応答を標的とした新規治療の開発 (Project/Area Number: 17K11013 )
  • The study of endoplasmic reticulum stress pathway in mechanical stress-loaded chondrocyte (Project/Area Number: 26462303 )
  • Involvement of endoplasmic reticulum stress induced by mechanical stress in the pathogenesis of cartilage degeneration (Project/Area Number: 25462374 )
  • Functional analysis of endoplasmic reticulum stress in the progression of cartilage degeneration (Project/Area Number: 23592219 )
  • Involvement of oxidative stress and endoplasmic reticulum stress inthe pathogenesis of cartilage degeneration (Project/Area Number: 22591659 )
  • Pathogenesis and pathological role of endoplasmic reticulum stress in cartilage degeneration (Project/Area Number: 20591784 )
  • Accumulation of advanced glycation end products in diabetic joint tissues and cartilage degeneration (Project/Area Number: 19591759 )
  • Search by Researcher Number (40433007)