Tokushima University / Educator and Researcher Directory --- Osaki, Yusuke

Personal Web Page

https://researchmap.jp/yosaki1124 (researchmap)

https://orcid.org/0000-0001-6588-5442 (ORCID)

Field of Study

○	Life sciences [Neurology]

Subject of Study

Book / Paper

Book:

1.	Ryosuke Oki, Yusuke Osaki and Yuishin Izumi : 運動ニューロン疾患，1．筋萎縮性側索硬化症(非遺伝性), 株式会社中外医学社, Mar. 2024.
2.	Ryosuke Oki, Yusuke Osaki and Yuishin Izumi : F運動ニューロン疾患筋萎縮性側索硬化症(非遺伝性), 株式会社中外医学社, Jan. 2022.

Academic Paper (Judged Full Paper):

1.	Kenta Hanada, Yusuke Osaki, Ryosuke Miyamoto, Kohei Muto, Shotaro Haji, Keyoumu Nazere, Yuki Kuwano, Hiroyuki Morino, Yoshiteru Azuma, Satoko Miyatake, Naomichi Matsumoto and Yuishin Izumi : Intermediate phenotype between CMT2Z and DIGFAN associated with a novel MORC2 variant: a case report., Human Genome Variation, Vol.11, No.1, 2024. (Summary) Charcot-Marie-Tooth disease type 2Z is caused by MORC2 mutations and presents with axonal neuropathy. MORC2 mutations can also manifest as developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN). We report a patient exhibiting an intermediate phenotype between these diseases associated with a novel MORC2 variant. A literature review revealed that the genotype‒phenotype correlation in MORC2-related disorders is complex and that the same mutation can cause a variety of phenotypes. (Link to Publication Site) ● Publication site (DOI): 10.1038/s41439-024-00287-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39143067 ● Search Scopus @ Elsevier (PMID): 39143067 ● Search Scopus @ Elsevier (DOI): 10.1038/s41439-024-00287-8 (DOI: 10.1038/s41439-024-00287-8, PubMed: 39143067)
2.	Satoko Miyatake, Hiroshi Doi, Hiroaki Yaguchi, Eriko Koshimizu, Naoki Kihara, Tomoyasu Matsubara, Yasuko Mori, Kenjiro Kunieda, Yusaku Shimizu, Tomoko Toyota, Shinichi Shirai, Masaaki Matsushima, Masaki Okubo, Taishi Wada, Misako Kunii, Ken Johkura, Ryosuke Miyamoto, Yusuke Osaki, Takabumi Miyama, Mai Satoh, Atsushi Fujita, Yuri Uchiyama, Naomi Tsuchida, Kazuharu Misawa, Kohei Hamanaka, Haruka Hamanoue, Takeshi Mizuguchi, Hiroyuki Morino, Yuishin Izumi, Takayoshi Shimohata, Kunihiro Yoshida, Hiroaki Adachi, Fumiaki Tanaka, Ichiro Yabe and Naomichi Matsumoto : Complete nanopore repeat sequencing of SCA27B (GAA-FGF14 ataxia) in Japanese., Journal of Neurology, Neurosurgery, and Psychiatry, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1136/jnnp-2024-333541 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38816190 ● Search Scopus @ Elsevier (PMID): 38816190 ● Search Scopus @ Elsevier (DOI): 10.1136/jnnp-2024-333541 (DOI: 10.1136/jnnp-2024-333541, PubMed: 38816190)
3.	Koji Fukushima, T Yoshida, Hiroki Yamazaki, N Takamatsu, T Nagai, Yusuke Osaki, Masafumi Harada, I Nishino, N Okiyama, K Sugie and Yuishin Izumi : A Case of Anti-NXP2 Antibody-positive Juvenile Dermatomyositis with Characteristic Fascial Thickening on Muscle Ultrasound and Improvement with Immunotherapy, Internal Medicine, 2023. (Summary) We herein report a 12-year-old boy who presented with a fever, erythematous rash on the cheeks, back pain, and dysphagia. Blood tests revealed increased creatine kinase levels, and muscle ultrasonography (MUS) revealed characteristic fascial thickening in the lumbar paraspinal muscles, where myalgia was prominent. Sarcoplasmic expression of myxovirus-resistant protein A on a muscle biopsy and the presence of anti-nuclear matrix protein 2 (NXP2) antibodies confirmed the diagnosis of dermatomyositis. Prednisolone and intravenous immunoglobulin therapy improved the clinical and laboratory parameters as well as fascial thickening. MUS is useful for evaluating fasciitis associated with anti-NXP2 autoantibodies and monitoring therapeutic efficacy. (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.2720-23 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37926535 ● Search Scopus @ Elsevier (PMID): 37926535 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.2720-23 (DOI: 10.2169/internalmedicine.2720-23, PubMed: 37926535)
4.	Kenta Hanada, Yusuke Osaki, Koji Fujita, Tatsuya Fukumoto, Koji Fukushima, Hideki Kito and Yuishin Izumi : Segmental Zoster Paresis Accompanied by Horner's Syndrome., Internal Medicine, Vol.62, No.18, 2743-2746, 2023. (Summary) We herein report a 90-year-old immunocompromised woman who developed right upper limb weakness and right ptosis with a miotic pupil 1 week after oral therapy for zoster on the right T2 dermatome. The right pupil was dilated with instillation of 1% apraclonidine, indicating Horner's syndrome. The patient was treated with intravenous acyclovir and methylprednisolone. Focal weakness related to zoster, generally known as segmental zoster paresis, improved over five months, but Horner's syndrome remained. We suggest that aggressive intravenous treatment should be considered for rare cases of zoster that occur with a combination of these two neurological conditions. (Keyword) Aged, 80 and over / Female / Humans / Acyclovir / Blepharoptosis / Herpes Zoster / Horner Syndrome / Paresis (Tokushima University Institutional Repository) ● Metadata: 119241 (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.0578-22 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37722924 ● Search Scopus @ Elsevier (PMID): 37722924 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0578-22 (Tokushima University Institutional Repository: 119241, DOI: 10.2169/internalmedicine.0578-22, PubMed: 37722924)
5.	Shotaro Haji, Ryosuke Miyamoto, Hiroyuki Morino, Yusuke Osaki, Seijiro Tsuji, Ichizo Nishino, Masahiro Abe and Yuishin Izumi : Autosomal Recessive Spinocerebellar Ataxia Type 9 With a Response to Phosphate Repletion: A Case Report., Neurology. Genetics, Vol.9, No.3, e200070, 2023. (Summary) This provides Class IV evidence. This is a single observational study without controls. (Link to Publication Site) ● Publication site (DOI): 10.1212/NXG.0000000000200070 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37529414 ● Search Scopus @ Elsevier (PMID): 37529414 ● Search Scopus @ Elsevier (DOI): 10.1212/NXG.0000000000200070 (DOI: 10.1212/NXG.0000000000200070, PubMed: 37529414)
6.	Takeshi Yoshida, Hiroki Yamazaki, Y Nishimori, Naoko Takamatsu, Koji Fukushima, Yusuke Osaki, Y Taniguchi, T Nozaki, Y Kumon, J Albayda, I Nishino and Yuishin Izumi : Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies, Muscle & Nerve, Vol.68, No.1, 39-47, 2023. (Summary) In idiopathic inflammatory myopathies (IIMs), the change in muscle echogenicity and its histopathological basis are not well understood. We quantitatively measured muscle echogenicity in patients with IIMs and evaluated its correlation with disease activity and histopathological findings. This study involved patients with IIMs who underwent both ultrasonography (US) and muscle biopsy, as well as age- and sex-matched rheumatoid arthritis patients as inflammatory disease controls. On US, axial images of the right biceps brachii and vastus medialis were obtained. Standardized histopathological scoring was used to quantitatively measure each pathological domain. Forty-two patients (17 with inclusion body myositis [IBM] and 25 with IIMs other than IBM) and 25 controls were included. The muscle echo intensity (EI) of patients with IIMs was significantly higher than that of controls. Muscle EI showed significant correlations with creatine kinase (r = 0.66, p < .001) and muscle strength (r = -0.73, p < .0001) in patients with non-IBM IIMs. In patients with IBM, moderate correlation was found between muscle EI and quadriceps muscle strength (r = -0.53, p = .028). Histopathologically, the number of infiltrating CD3+ inflammatory cells correlated with muscle EI in the non-IBM group (r = 0.56, p = .017), but not in the IBM group. Muscle EI may be useful as a surrogate marker of muscle inflammation in non-IBM IIM. Increased muscle EI may be difficult to interpret in patients with long-standing IBM, which has advanced and complex histopathology. (Keyword) Humans / Myositis / Muscle, Skeletal / Myositis, Inclusion Body / Ultrasonography / Muscle Strength (Link to Publication Site) ● Publication site (DOI): 10.1002/mus.27833 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37118940 ● Summary page in Scopus @ Elsevier: 2-s2.0-85158067048 (DOI: 10.1002/mus.27833, PubMed: 37118940, Elsevier: Scopus)
7.	Wataru Sako, Shotaro Haji, Takashi Abe, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Yuishin Izumi : M1/precuneus ratio as a surrogate marker of upper motor neuron sign in ALS, Journal of the Neurological Sciences, Vol.445, 120548, 2023. (Summary) To investigate whether primary motor cortex (M1) volume measured with an automated approach in MRI reflects upper motor neuron dysfunction and whether it can serve as a potential diagnostic and/or disease-tracking biomarker for amyotrophic lateral sclerosis (ALS). In this retrospective study, we enrolled 95 subjects, including 33 possible or laboratory supported probable ALS, 26 probable or definite ALS (Prob/Def), 2 primary lateral sclerosis patients, 8 progressive muscular atrophy patients, 19 normal controls (NC) and 7 ALS patients having a second structural MRI scan. Some subjects also underwent functional MRI. We calculated M1, primary sensory cortex, precuneus volumes, and total gray matter volume (TGMV) with FreeSurfer. The sensorimotor network (SMN) was identified using independent component analysis. The M1/precuneus ratio showed a significant difference between the NC and Prob/Def groups (p < 0.05). The diagnostic accuracy of the M1/precuneus ratio was moderate for distinguishing Prob/Def from NC (cutoff = 1.00, sensitivity = 0.42, specificity = 0.90). Two of eight cases without upper motor neuron dysfunction could be diagnosed with ALS using M1/precuneus ratio as a surrogate marker. A negative correlation between M1/precuneus ratio and functional activity was found in Brodmann area 6 in the SMN in all subjects. TGMV tended to decrease with disease progression (p = 0.04). The M1/precuneus volume ratio, associated with the SMN, may have potential as a surrogate biomarker of upper motor neuron dysfunction in ALS. Furthermore, TGMV may serve as an ALS disease-tracking biomarker. (Keyword) Humans / Amyotrophic Lateral Sclerosis / Retrospective Studies / Magnetic Resonance Imaging / Parietal Lobe / Motor Cortex / Biomarkers / Motor Neurons / Motor Neuron Disease (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jns.2023.120548 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36640663 ● Search Scopus @ Elsevier (PMID): 36640663 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jns.2023.120548 (DOI: 10.1016/j.jns.2023.120548, PubMed: 36640663)
8.	Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino, Seiichi Nagano, Naoki Atsuta, Yuki Kanazawa, Yuki Matsumoto, Atsuko Arisawa, Hisashi Kawai, Yasutaka Sato, Satoshi Sakaguchi, Kenta Yagi, Tatsuto Hamatani, Tatsuo Kagimura, Hiroaki Yanagawa, Hideki Mochizuki, Manabu Doyu, Gen Sobue, Masafumi Harada and Yuishin Izumi : An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study, JMIR Research Protocols, Vol.12, e42032, 2023. (Summary) Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, with its currently approved drugs, including riluzole and edaravone, showing limited therapeutic effects. Therefore, safe and effective drugs are urgently necessary. EPI-589 is an orally available, small-molecule, novel redox-active agent characterized by highly potent protective effects against oxidative stress with high blood-brain barrier permeability. Given the apparent oxidative stress and mitochondrial dysfunction involvement in the pathogenesis of ALS, EPI-589 may hold promise as a therapeutic agent. This protocol aims to describe the design and rationale for the EPI-589 Early Phase 2 Investigator-Initiated Clinical Trial for ALS (EPIC-ALS). EPIC-ALS is an explorative, open-labeled, single-arm trial that evaluates the safety and tolerability of EPI-589 in patients with ALS. This trial consists of 12-week run-in, 24-week treatment, and 4-week follow-up periods. Patients will receive 500 mg of EPI-589 3 times daily over the 24-week treatment period. Clinical assessments include the mean monthly change of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised total score. The biomarkers are selected to analyze the effect on oxidative stress and neuronal damage. The plasma biomarkers are 8-hydroxy-2'-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), neurofilament light chain (NfL), phosphorylated neurofilament heavy chain (pNfH), homocysteine, and creatinine. The cerebrospinal fluid biomarkers are 8-OHdG, 3-NT, NfL, pNfH, and ornithine. The magnetic resonance biomarkers are fractional anisotropy in the corticospinal tract and N-acetylaspartate in the primary motor area. This trial began data collection in September 2021 and is expected to be completed in October 2023. This study can provide useful data to understand the characteristics of EPI-589. Japan Primary Registries Network jRCT2061210031; tinyurl.com/2p84emu6. DERR1-10.2196/42032. (Tokushima University Institutional Repository) ● Metadata: 118866 (Link to Publication Site) ● Publication site (DOI): 10.2196/42032 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36716091 ● Summary page in Scopus @ Elsevier: 2-s2.0-85149143248 (Tokushima University Institutional Repository: 118866, DOI: 10.2196/42032, PubMed: 36716091, Elsevier: Scopus)
9.	Naoko Matsui, Mika Takahara, Hiroki Yamazaki, Naoko Takamatsu, Yusuke Osaki, Ryuji Kaji, Ichizo Nishino, Satoshi Yamashita and Yuishin Izumi : A case of anti-NT5c1A antibody-seropositive inclusion body myositis associated with severe dysphagia and prominent forearm weakness, Neurology and Clinical Neuroscience, Vol.11, No.1, 46-48, 2022. (Link to Publication Site) ● Publication site (DOI): 10.1111/ncn3.12678 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1111/ncn3.12678 (DOI: 10.1111/ncn3.12678)
10.	Hiroki Yamazaki, Naoko Matsui, N Takamatsu, Takeshi Yoshida, Koji Fukushima, T Takata, Yusuke Osaki, K Tanaka, Y Kubo and Yuishin Izumi : Application of ultrasound in a case of eosinophilic fasciitis mimicking stiff-person syndrome, Neuromuscular Disorders, Vol.32, No.7, 590-593, 2022. (Summary) Eosinophilic fasciitis (EF) is a rare disorder characterized by muscle stiffness mimicking other neuromuscular diseases. The diagnosis of EF is made on the basis of typical skin lesions. We report a case of a 36-year-old male patient with suspected stiff-person syndrome (SPS), who presented with progressive limb muscle stiffness and limited mobility of both wrists without obvious skin changes. Ultrasound revealed fascial thickening of bilateral upper and lower limb muscles and enlargement of hypoechoic tissues around the flexor digitorum tendons of the wrist. Skin and fascia biopsy confirmed the diagnosis of EF. Prednisolone therapy resulted in the improvement of muscle stiffness and tightness. Our findings suggest the need to consider connective tissue diseases such as EF in a patient with atypical features of SPS. Ultrasound is helpful for visualizing the causes of muscle stiffness and joint contractures in EF patients. (Keyword) Adult / Eosinophilia / Fasciitis / Humans / Male / Prednisolone / Stiff-Person Syndrome (Link to Publication Site) ● Publication site (DOI): 10.1016/j.nmd.2022.05.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35672204 ● Search Scopus @ Elsevier (PMID): 35672204 ● Search Scopus @ Elsevier (DOI): 10.1016/j.nmd.2022.05.009 (DOI: 10.1016/j.nmd.2022.05.009, PubMed: 35672204)
11.	Koji Fukushima, Naoko Takamatsu, Yuki Yamamoto, Hiroki Yamazaki, Takeshi Yoshida, Yusuke Osaki, Shotaro Haji, Koji Fujita, Kazuma Sugie and Yuishin Izumi : Early diagnosis of amyotrophic lateral sclerosis based on fasciculations in muscle ultrasonography: A machine learning approach., Clinical Neurophysiology, Vol.140, 136-144, 2022. (Summary) Fasciculation detected in relevant muscles on MUS can contribute to the diagnosis of ALS from the early stage. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.clinph.2022.06.005 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35772191 ● Search Scopus @ Elsevier (PMID): 35772191 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clinph.2022.06.005 (DOI: 10.1016/j.clinph.2022.06.005, PubMed: 35772191)
12.	Shotaro Haji, Wataru Sako, N Marukami, Yusuke Osaki and Yuishin Izumi : Serum NfL and CHI3L1 for ALS and parkinsonian disorders in the process of diagnosis, Journal of Neural Transmission, Vol.129, No.3, 301-309, 2022. (Summary) Serum neurofilament light chain (NfL) and chitinase 3-like 1 (CHI3L1, also called YKL-40) concentrations are attractive candidate biomarkers for neurodegenerative disorders, which include amyotrophic lateral sclerosis (ALS) and parkinsonian disorders. We aimed to assess the diagnostic power of serum NfL and CHI3L1 concentrations with regard to the early diagnosis of ALS and Parkinson's disease (PD). We studied 157 individuals, which included 41 healthy controls, 8 patients with ALS mimics, 18 patients initially diagnosed with ALS (ID-ALS), 32 patients late-diagnosed with ALS (LD-ALS), 29 patients with PD, 12 patients with PD mimics, and 17 patients initially diagnosed with atypical parkinsonian disorders (ID-APDs) at the initial stage of diagnosis. Electrochemiluminescence was used to measure the concentrations of serum NfL and CHI3L1, the diagnostic performance of which was assessed using the area under the receiver operating curves (AUCs). The AUCs of serum NfL were 0.90 for discriminating ALS mimics from LD-ALS at the initial stage of diagnosis and 0.89 for discriminating ALS mimics from ALS (LD/ID-ALS). The AUCs of serum NfL were 0.76 for discriminating PD from PD mimics at the initial stage of diagnosis, and 0.80 for discriminating PD from APD. No significant difference existed in serum CHI3L1 concentrations between individuals with suspected ALS or parkinsonism (p = 0.14, and p = 0.44, respectively). Serum NfL had excellent and almost good diagnostic performances for patients with ALS and PD, respectively, at the initial stage of diagnosis, whereas no significant difference existed in serum CHI3L1 between any groups. (Keyword) Amyotrophic Lateral Sclerosis / Biomarkers / Chitinase-3-Like Protein 1 / Humans / Parkinson Disease / Parkinsonian Disorders (Link to Publication Site) ● Publication site (DOI): 10.1007/s00702-022-02470-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35178615 ● Search Scopus @ Elsevier (PMID): 35178615 ● Search Scopus @ Elsevier (DOI): 10.1007/s00702-022-02470-z (DOI: 10.1007/s00702-022-02470-z, PubMed: 35178615)
13.	Yusuke Osaki, 島かさ音, Nobuaki Yamamoto, Hiroki Yamazaki, Kenta Sato and Yuishin Izumi : 血管炎性ニューロパチー様の臨床像で発症した抗Hu抗体陽性脳脊髄炎の1例, Peripheral Nerve, Vol.33, No.1, 136-143, 2022. (Keyword) 傍腫瘍性神経症候群 / 抗Hu抗体 / 非対称性ニューロパチー / paraneoplastic neurological syndrome / anti-Hu antibody / asymmetric neuropathy (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520013010160046720 (CiNii: 1520013010160046720)
14.	Wataru Sako, Yuishin Izumi, Takashi Abe, Shotaro Haji, Nagahisa Murakami, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Ryuji Kaji : MR spectroscopy and imaging-derived measurements in the supplementary motor area for biomarkers of amyotrophic lateral sclerosis, Neurological Sciences, Vol.42, No.10, 4257-4263, 2021. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10072-021-05107-3 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85100872799 (DOI: 10.1007/s10072-021-05107-3, Elsevier: Scopus)
15.	Yusuke Osaki, Hiroyuki Nodera, Tatsuya Fukumoto, Ryuji Kaji and Yuishin Izumi : Peripheral nerve dysfunction in a patient with thyrotoxic periodic paralysis: Evidence from an axonal prolonged exercise test, Clinical Neurophysiology, Vol.132, No.7, 1496-1498, 2021. (Keyword) Adolescent / Adult / Axons / Exercise Test / Humans / Hypokalemic Periodic Paralysis / Male / Peripheral Nerves (Link to Publication Site) ● Publication site (DOI): 10.1016/j.clinph.2021.04.006 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34030052 ● Summary page in Scopus @ Elsevier: 2-s2.0-85106374066 (DOI: 10.1016/j.clinph.2021.04.006, PubMed: 34030052, Elsevier: Scopus)
16.	Wataru Sako, T Abe, Y Matsumoto, K Nakamura, Shotaro Haji, Yusuke Osaki, Masafumi Harada and Yuishin Izumi : The cerebellum is a common key for visuospatial execution and attention in Parkinson's disease, Diagnostics, Vol.11, No.6, 1042, 2021. (Summary) Cognitive decline affects the clinical course in patients with Parkinson's disease (PD) and contributes to a poor prognosis. However, little is known about the underlying network-level abnormalities associated with each cognitive domain. We aimed to identify the networks related to each cognitive domain in PD using resting-state functional magnetic resonance imaging (MRI). Forty patients with PD and 15 normal controls were enrolled. All subjects underwent MRI and the Mini-Mental State Examination. Furthermore, the cognitive function of patients with PD was assessed using the Montreal Cognitive Assessment (MoCA). We used independent component analysis of the resting-state functional MRI for functional segmentation, followed by reconstruction to identify each domain-related network, to predict scores in PD using multiple regression models. Six networks were identified, as follows: the visuospatial-executive-domain-related network ( = 0.54, < 0.001), naming-domain-related network ( = 0.39, < 0.001), attention-domain-related network ( = 0.86, < 0.001), language-domain-related network ( = 0.64, < 0.001), abstraction-related network ( = 0.10, < 0.05), and orientation-domain-related network ( = 0.64, < 0.001). Cerebellar lobule VII was involved in the visuospatial-executive-domain-related and attention-domain-related networks. These two domains are involved in the first three listed nonamnestic cognitive impairment in the diagnostic criteria for PD with dementia (PDD). Furthermore, Brodmann area 10 contributed most frequently to each domain-related network. Collectively, these findings suggest that cerebellar lobule VII may play a key role in cognitive impairment in nonamnestic types of PDD. (Keyword) Parkinson's disease / cognition / functional MRI / network / cerebellum (Tokushima University Institutional Repository) ● Metadata: 116520 (Link to Publication Site) ● Publication site (DOI): 10.3390/diagnostics11061042 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34204073 ● CiNii @ National Institute of Informatics (CRID): 1050021072400356992 ● Summary page in Scopus @ Elsevier: 2-s2.0-85108274727 (Tokushima University Institutional Repository: 116520, DOI: 10.3390/diagnostics11061042, PubMed: 34204073, CiNii: 1050021072400356992, Elsevier: Scopus)
17.	Kohei Muto, Ryosuke Miyamoto, Yuka Terasawa, Yoshimitsu Shimatani, Keijiro Hara, Takumi Kakimoto, Tatsuya Fukumoto, Yusuke Osaki, Koji Fujita, Masafumi Harada, Hisanori Uehara, Yasushi Takagi and Yuishin Izumi : A novel COL4A1 variant associated with recurrent epistaxis and glioblastoma, Human Genome Variation, Vol.8, No.1, 18, 2021. (Tokushima University Institutional Repository) ● Metadata: 116530 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41439-021-00150-0 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85105944271 (Tokushima University Institutional Repository: 116530, DOI: 10.1038/s41439-021-00150-0, Elsevier: Scopus)
18.	Shotaro Haji, Wataru Sako, Nagahisa Murakami, Yusuke Osaki, Takahiro Furukawa, Yuishin Izumi and Ryuji Kaji : The value of serum uric acid as a prognostic biomarker in amyotrophic lateral sclerosis: Evidence from a meta-analysis, Clinical Neurology and Neurosurgery, Vol.203, 106566, 2021. (Tokushima University Institutional Repository) ● Metadata: 116650 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.clineuro.2021.106566 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2021.106566 (Tokushima University Institutional Repository: 116650, DOI: 10.1016/j.clineuro.2021.106566)
19.	Yusuke Osaki, Wataru Sako, Masafumi Harada and Yuishin Izumi : Magnetic resonance tractography exhibiting retrograde degeneration of the corticospinal tract in a patient with a unilateral spinal cord tumor, Brain and Behavior, Vol.11, No.4, e02020, 2021. (Tokushima University Institutional Repository) ● Metadata: 116501 (Link to Publication Site) ● Publication site (DOI): 10.1002/brb3.2020 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/brb3.2020 (Tokushima University Institutional Repository: 116501, DOI: 10.1002/brb3.2020)
20.	CT Suratos, N Takamatsu, Hiroki Yamazaki, Yusuke Osaki, T Fukumoto, Hiroyuki Nodera and Yuishin Izumi : Utility of phrenic nerve ultrasound in amyotrophic lateral sclerosis, Acta Neurologica Belgica, Vol.121, No.1, 225-230, 2021. (Tokushima University Institutional Repository) ● Metadata: 116266 (Link to Publication Site) ● Publication site (DOI): 10.1007/s13760-020-01531-y (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85094859144 (Tokushima University Institutional Repository: 116266, DOI: 10.1007/s13760-020-01531-y, Elsevier: Scopus)
21.	高松直子, Yusuke Osaki, Hiroki Yamazaki, Kazutaka Kuroda, Hirohisa Ogawa, Hisanori Uehara, Koichi Tsuneyama, Hiroyuki Nodera and Yuishin Izumi : A case of led to diagnosis of malignancy by brachial plexus ultrasonography, Neurosonology, Vol.33, No.2, 36-40, 2020. (Summary) A 72-year-old man admitted to our hospital due to severe pain and drop hand in the left arm. MRI and CT of the head and neck at an outside hospital showed no abnormality. Neurological findings revealed distal weakness in the left upper extremity, vague pain between the radial aspect of the left hand and the middle of the digits 1-3, as well as brisk reflexes in the left extremities. Small masses were palpable in the posterior neck, the lower jaw, and the left neck. Clinically, left radial neuropathy and cervical radiculopathy were suspected. We performed ultrasound of the nerve roots, brachial plexus, and the radial nerve. There was a mass compressing the left brachial plexus from the caudolateral direction. Additionally, nerve swelling in the left arm was identified. Skin biopsy over the mass suggested metastatic adenocarcinoma. Chest CT scan showed a mass in the upper right lobe suggestive of a lung cancer. We concluded that the pain was due to radial neuropathy and upper and middle trunk disturbance of the left brachial plexopathy, of which neuromuscular ultrasound was useful in diagnosis. (Keyword) upper limb pain / brachial plexus ultrasound / metastasis (Link to Publication Site) ● Publication site (DOI): 10.2301/neurosonology.33.36 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390567172576336384 ● Search Scopus @ Elsevier (DOI): 10.2301/neurosonology.33.36 (DOI: 10.2301/neurosonology.33.36, CiNii: 1390567172576336384)
22.	Wataru Sako, Takashi Abe, Shotaroh Haji, Nagahisa Murakami, Yusuke Osaki, Yuishin Izumi, Masafumi Harada and Ryuji Kaji : A method for differential diagnosis of parkinsonian syndromes, Acta Neurologica Scandinavica, Vol.140, No.3, 229-235, 2019. (Summary) Neurological findings are important for the differential diagnosis of Parkinson's disease (PD), multiple system atrophy with predominant parkinsonian features (MSA-P), and progressive supranuclear palsy (PSP). There is currently no fast and reliable method to distinguish these patients. To address this, we propose a novel approach to measure midbrain and pons size using a longitudinal "one line" method from the mid-sagittal view. Structural images were acquired from 101 subjects who underwent 3.0 T MRI (20 controls, 44 PD, 20 MSA, 12 PSP, and 5 corticobasal syndrome). We measured the middle cerebellar peduncle (MCP), superior cerebellar peduncle (SCP), midbrain, and pons. Brainstem size was measured by area or length of the longitudinal axis, which we named the "one line" method. We conducted intraclass correlation coefficients to assess the extent of agreement and consistency among raters, and receiver operating characteristic curves were used to determine diagnostic accuracy. Intraclass correlation coefficients (ICC) of MCP width were excellent in sagittal and axial sections while those of SCP width were moderate. There were also excellent ICCs between raters for "one line" method of the midbrain and pons, while areas showed good ICCs. "One line" method and area of the midbrain were better than SCP width for the differential diagnosis of PSP from MSA-P and PD. In contrast, there was no clearly superior measurement for differentially diagnosing MSA-P. The "one line" method was comparable with area for inter-rater agreement and diagnostic accuracy even though this was a simple and fast way. (Keyword) Aged / Diagnosis, Differential / Female / Humans / Magnetic Resonance Imaging / Male / Mesencephalon / Middle Aged / Multiple System Atrophy / Parkinsonian Disorders / Pons / Supranuclear Palsy, Progressive (Link to Publication Site) ● Publication site (DOI): 10.1111/ane.13136 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31225648 ● Summary page in Scopus @ Elsevier: 2-s2.0-85067842485 (DOI: 10.1111/ane.13136, PubMed: 31225648, Elsevier: Scopus)
23.	Toshitaka Kawarai, Hiroki Yamazaki, Ryosuke Miyamoto, Naoko Takamatsu, Atsuko Mori, Yusuke Osaki, Antonio Orlacchio, Hiroyuki Nodera, Akihiro Hashiguchi, Yujiro Higuchi, Akiko Yoshimura, Hiroshi Takashima and Ryuji Kaji : PMP22-related disease: A novel splice site acceptor variant and intrafamilial phenotype variability., Neuromuscular Disorders, Vol.26, No.6, 422-426, 2019. (Summary) PMP22 is the most frequent mutated gene in Charcot-Marie-Tooth disease (CMT) type 1A. Another phenotype, hereditary neuropathy with pressure palsies (HNPP), could be caused by PMP22 mutations. PMP22 encodes a peripheral myelin protein with molecular weight 22-kDa. Various pathomechanisms have been postulated in PMP22-related disease, including dysfunction due to missense mutations, and alteration of a gene dose due to duplication/deletion mutations. We identified a novel PMP22 splice site acceptor variant, c.179-1G>A, in a patient with adult-onset chronic generalized polyneuropathy and two asymptomatic family members. Pathophysiological features of the members mainly overlapped with those reported in HNPP, but broad intrafamilial clinical variations were observed. PMP22 transcripts lacking of exon 4 were produced by the variant, presumably leading to in-frame deletion of 47 amino acids. The variant was also shown to exert effect on dosage of PMP22 mRNA. The complex molecular pathology would lead to the unique clinical and pathophysiological conditions. (Keyword) Adult / family / female / Gene Dosage / Hereditary Sensory and Motor Neuropathy / Humans / male / Middle Aged / Mutation / Myelin Proteins / Pedigree / Phenotype / Polyneuropathies / RNA Splice Sites (Link to Publication Site) ● Publication site (DOI): 10.1016/j.nmd.2019.03.010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31122831 ● Summary page in Scopus @ Elsevier: 2-s2.0-85065707113 (DOI: 10.1016/j.nmd.2019.03.010, PubMed: 31122831, Elsevier: Scopus)
24.	Naoko Matsui, Hiroyuki Nodera, D Kuzume, N Iwasa, Y Unai, W Sakai, Y Miyazaki, H Yamazaki, Yusuke Osaki, A Mori, T Furukawa, A Tsukamoto-Miyashiro, Y Shimatani, M Yamasaki, Yuishin Izumi, S Kusunoki, Kokichi Arisawa and Ryuji Kaji : Guillan-Barre syndrome in local area in Japan, 2006-2015: an epidemiological and clinical study of 108 patients, European Journal of Neurology, Vol.25, No.5, 718-724, 2018. (Summary) Many epidemiological studies of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) have been conducted in Europe and America. In contrast, epidemiological studies are rare in Asia where the GBS subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of GBS and FS in a local area in Japan as well as their seasonal trends. Seventy-one GBS and 37 FS patients were recorded from 2006 to 2015 in an area of approximately 1.5 million inhabitants in Japan. The incidence, seasonal trends and clinical features of GBS and FS were examined. The incidence rate of GBS was 0.42 cases per 100 000 person-years and that of FS was 0.22 cases per 100 000 person-years. The incidence of GBS increased with age and FS affected predominantly patients aged from 45 to 64 years old. There was some seasonal clustering of acute motor axonal neuropathy (AMAN) and FS in spring and summer, but it was not significant. AMAN and FS patients had a high frequency of preceding infection (AMAN, 68% gastrointestinal infection; FS, 65% upper respiratory infection). Antecedent respiratory infection was significantly associated with FS as an outcome. Serum antibodies to ganglioside GM1 were detected in 71% of AMAN patients and antibodies to GQ1b were detected in 81% of FS patients. Our study offers evidence of a lower incidence of GBS and a higher incidence of FS in a local area in Japan than in Western countries. (Link to Publication Site) ● Publication site (DOI): 10.1111/ene.13569 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29337417 ● Summary page in Scopus @ Elsevier: 2-s2.0-85042582939 (DOI: 10.1111/ene.13569, PubMed: 29337417, Elsevier: Scopus)
25.	山上圭, Takahiro Furukawa, Yusuke Osaki, 村上永尚, 中道一生, 西條政幸, Naoko Matsui, Yuishin Izumi and Ryuji Kaji : 未治療のサルコイドーシスに合併した進行性多巣性白質脳症, Neuroinfection, Vol.23, No.1, 151-156, 2018.
26.	Koji Fujita, Yusuke Osaki, Ryosuke Miyamoto, Shimatani Yoshimitsu, Takashi Abe and Shimatani Yoshimitsu : Neurologic attack and dynamic perfusion abnormality in neuronal intranuclear inclusion disease, Neurology. Clinical Practice, Vol.7, No.6, e39-e42, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1212/CPJ.0000000000000389 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29431160 ● Search Scopus @ Elsevier (PMID): 29431160 ● Search Scopus @ Elsevier (DOI): 10.1212/CPJ.0000000000000389 (DOI: 10.1212/CPJ.0000000000000389, PubMed: 29431160)

Review, Commentary:

1.	Yusuke Osaki and Yuishin Izumi : ニューロパチーからみたRFC1遺伝子関連スペクトラム障害, Brain and Nerve = Shinkei kenkyū no shinpo, Vol.74, No.11, 1281-1286, Nov. 2022. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1416202228 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390012556788804992 ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1416202228 (DOI: 10.11477/mf.1416202228, CiNii: 1390012556788804992)
2.	Yusuke Osaki and Yuishin Izumi : ALSの診断基準:Awaji基準までの変遷を中心に, Home Health Care for the People with Intractable Diseases, Vol.27, No.3, 40-44, Jun. 2021. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523669555953827840 (CiNii: 1523669555953827840)
3.	Yusuke Osaki, 高松直子 and Yuishin Izumi : 筋電図検査における検査技師の役割は何か(医師の立場から), Japanese Journal of Clinical Neurophysiology, Vol.49, No.2, 85-88, Apr. 2021. (Summary) <p>筋電図検査は患者個別に最適化を要し, その最適化には検査特性や神経筋疾患の病態に関する専門的知識が求められる．筋電図検査が神経筋疾患の診療に有効であるためには, 少なくとも専門知識を持った監督者が検査実施現場に配置される必要がある．その監督業務を担うための技能取得が, 今後ますます検査技師に求められていく可能性がある．厚生労働省はタスク・シフティング等医療勤務環境改善推進事業において, 検査業務を医師から技師に移していく方針を掲げているためである．本稿では, 筋電図検査における検査技師の役割は何かという問いに対して本学会内での議論を活発化させることを目的として, 筋電図検査実施体制について当院での体制を例示し, 現状とタスク・シフトが求められている時流を踏まえた理想像について述べる．</p> (Link to Publication Site) ● Publication site (DOI): 10.11422/jscn.49.85 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390006076308478976 ● Search Scopus @ Elsevier (DOI): 10.11422/jscn.49.85 (DOI: 10.11422/jscn.49.85, CiNii: 1390006076308478976)

Proceeding of International Conference:

1.	Yusuke Osaki, Hiroyuki Nodera, Ryosuke Miyamoto, Hiroyuki Morino, M Chan, Ryuji Kaji and Yuishin Izumi : Peripheral nerve excitability abnormality in spinocerebellar ataxia type 6, Neuroscience 2023, Nov. 2023.
2.	Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Hiroyuki Morino, S Nagano, N Atsuta, Y Kanazawa, Y Matsumoto, A Arisawa, H Kawai, S Sakaguchi, K Yagi, T Hamatani, M Harada, G Sobue and Yuishin Izumi : An Exploratoruy Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS), Pan-Asian Consortium for Treatment and Research in ALS (PACTALS), Kuala Lumpur, Sep. 2023.
3.	Shotaro Haji, R Oki, Koji Fujita, Yusuke Osaki, S Nagano, N Atsuta, Y Kanazawa, Y Matsumoto, A Arisawa, H Kawai, Y Sato, S Sakaguchi, K Yaki, T Hamatani, Hiroaki Yanagawa, Masafumi Harada, G Sobue and Yuishin Izumi : EPI-589 early phase 2 investigator-initiated clinical trial for ALS (EPIC-ALS): protocol for an exploratory study, Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021.
4.	Hiroki Yamazaki, N Takamatsu, Koji Fukushima, Takeshi Yoshida, Yusuke Osaki and Yuishin Izumi : Application of nerve ultrasound for early diagnosis of ALS focus on brachial plexus, Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021.
5.	Koji Fukushima, N Takamatsu, Hiroki Yamazaki, Yusuke Osaki, Takeshi Yoshida, K Sugie and Yuishin Izumi : The specificity of faciculations in brainstem and thoracic region detected by muscle ultrasonography in ALS, A comparative muscle ultrasonographic investigation of 100 ALS patients and 100 non-ALS patients, Pan-Asia Consortium for Treatment and Research in ALS (PACTALS) 2021 NAGOYA, Nagoya, Sep. 2021.

Proceeding of Domestic Conference:

1.	Shotaro Haji, Wataru Sako, Nagahisa Murakami, Yusuke Osaki and Yuishin Izumi : メタ解析から見えるパーキンソン病のプラセボ効果の要因, 第53回日本神経精神薬理学会年会, Sep. 2023.
2.	Shotaro Haji, Wataru Sako, Koji Fukushima, HANADA Kenta, Yusuke Osaki, Yuki Matsumoto, Masafumi Harada and Yuishin Izumi : QSMを用いた視床下核の面先・磁化率評価は進行性核上性麻痺の診断に有用である, 第64回日本神経学会学術大会, Jun. 2023.
3.	Hiroki Yamazaki, 髙松直子, Koji Fukushima, HANADA Kenta, Yusuke Osaki and Yuishin Izumi : 発症早期ALSの診断における神経超音波を用いた脳神経叢評価の有用性, 第64回日本神経学会学術大会, May 2023.
4.	Hiroki Yamazaki, 髙松直子, Yusuke Osaki and Yuishin Izumi : どこまで追うべき!? 神経超音波によるuncommon nerveの描出の有用性, 第64回日本神経学会学術大会, May 2023.
5.	YAMAKAMI Kei, HANADA Kenta, Yuki Yamamoto, Hiroki Yamazaki, Yusuke Osaki, Naoko Matsui, Koji Fujita and Yuishin Izumi : 尿閉・便秘を呈したフィッシャー症候群の34歳男性例, 第112回日本神経学会中国・四国地方会, Dec. 2022.
6.	HANADA Kenta, Yusuke Osaki, Ryosuke Miyamoto, Shotaro Haji, Hiroyuki Morino and Yuishin Izumi : 新規のMORC2変異を認めたCharcot-Marie-Tooth病2Z型の1例, 第112回日本神経学会中国・四国地方会, Dec. 2022.
7.	Wataru Sako, Shotaro Haji, Takashi Abe, Yusuke Osaki, 松本友暉, Masafumi Harada and Yuishin Izumi : 運動ニューロン疾患の一次運動野の容積と感覚運動ネットワークの活動性との関連, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
8.	谷美紀, Yusuke Osaki, Hiroki Yamazaki, Koji Fukushima and Yuishin Izumi : 3回目の筋電図検査で診断に至った抗MuSK抗体陽性重症筋無力症の一例, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
9.	HANADA Kenta, Hiroki Yamazaki, 高松直子, Yusuke Osaki and Yuishin Izumi : 神経超音波検査で評価したneurolymphomatosisの1例,, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
10.	Yusuke Osaki, Hiroyuki Nodera, Hiroki Yamazaki, 高松直子, Ryuji Kaji and Yuishin Izumi : 誤診から学ぶ筋電図検査筋電図検査前の診断が困難な神経筋疾患同疾患3症例の提示, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
11.	Yusuke Osaki, Hiroyuki Nodera, Hiroki Yamazaki and Yuishin Izumi : 神経筋疾患の問題症例下肢近位筋・遠位筋筋力低下を来した脱髄性多発ニューロパチーの一例, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
12.	Naoko Matsui, Hiroki Yamazaki, 高松直子, Takeshi Yoshida, Koji Fukushima, 高田忠幸, Yusuke Osaki, 田中惠子, 久保宣明 and Yuishin Izumi : Stiff-person症候群との鑑別に筋超音波検査が有用であった好酸球性筋膜炎の一例,, 日本臨床神経生理学会第52回学術大会, Nov. 2022.
13.	Naoko Matsui, Hiroki Yamazaki, 高松直子, Takeshi Yoshida, Koji Fukushima, 高田忠幸, Yusuke Osaki, 田中惠子, 久保宣明 and Yuishin Izumi : Stiff-person症候群との鑑別に筋超音波検査が有用であった好酸球性筋膜炎の一例, 第34回日本神経免疫学会学術集会, Oct. 2022.
14.	HANADA Kenta, Yusuke Osaki, Ryosuke Miyamoto, Shotaro Haji, Hiroyuki Morino and Yuishin Izumi : MORC2新規変異を認めたCharcot-Marie-Tooth病2Z型の1例, 第33回日本末梢神経学会学術集会, Sep. 2022.
15.	HANADA Kenta, Yuki Yamamoto, Yusuke Osaki, 島かさ音, MUTO Kohei, Ryosuke Miyamoto, Koji Fujita and Yuishin Izumi : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第111回日本神経学会中国・四国地方会, Jun. 2022.
16.	HANADA Kenta, Yuki Yamamoto, Yusuke Osaki, 島かさ音, MUTO Kohei, Ryosuke Miyamoto, Koji Fujita and Yuishin Izumi : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第63回日本神経学会学術大会, May 2022.
17.	Hiroki Yamazaki, 高松直子, Koji Fukushima, Takeshi Yoshida, Yusuke Osaki and Yuishin Izumi : 脱髄性ニューロパチーの補助診断における神経超音波を用いた腕神経叢評価の有用性, 第63回日本神経学会学術大会, May 2022.
18.	Koji Fukushima, 高松直子, Yuki Yamamoto, Hiroki Yamazaki, Takeshi Yoshida, Shotaro Haji, Yusuke Osaki, Koji Fujita, 杉江和馬 and Yuishin Izumi : 筋超音波検査の線維束性収縮に基づく筋萎縮性側索硬化症の診断マーカー, 第63回日本神経学会学術大会, May 2022.
19.	Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino and Yuishin Izumi : Distal hereditary motor neuropathyを呈したMARS新規変異を有する1家系, 第63回日本神経学会学術大会, May 2022.
20.	Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Yuki Kanazawa, Yuki Matsumoto, 有澤亜津子, 川井恒, 佐藤康敬, Kenta Yagi, Satoshi Sakaguchi, Hiroaki Yanagawa, 濱谷辰斗, 長野清一, 望月秀樹, 熱田直樹, 道勇学, 祖父江元, Masafumi Harada and Yuishin Izumi : EPI-589の筋萎縮性側索硬化症を対象とした探索的医師主導試験(EPIC-ALS), 第63回日本神経学会学術大会, May 2022.
21.	HANADA Kenta, Yusuke Osaki and Yuishin Izumi : 筋萎縮性側索硬化症の発症年齢はどう変化しているか, 第33回日本老年医学会四国地方会, Jan. 2022.
22.	Yusuke Osaki : CIDP鑑別診断の要点, 第51回日本臨床神経生理学会学術大会ランチョンセミナー2, Dec. 2021.
23.	Yusuke Osaki, 島かさ音, Nobuaki Yamamoto, Hiroki Yamazaki, Kenta Sato and Yuishin Izumi : 非対称性ニューロパチー様の臨床像で発症した抗Hu抗体陽性脳脊髄炎の一例, 第32回日本末梢神経学会学術集会, Sep. 2021.
24.	松原知康, Yuishin Izumi, Shotaro Haji, Hiroki Yamazaki, Yusuke Osaki, Ryosuke Miyamoto, Koji Fujita, 齋藤祐子 and 村山繁雄 : Lewy小体型認知症と筋萎縮性側索硬化症を合併した1例, 第62回日本神経病理学会総会学術研究会, May 2021.
25.	島かさ音, Koji Fujita, Yusuke Osaki and Yuishin Izumi : 中枢神経ゴム腫で発症した梅毒の 1 例, 第124回日本内科学会四国地方会, May 2021.
26.	花田健太, Yusuke Osaki, 島かさ音, 武藤浩平, 福本竜也, Yuki Yamamoto, 鬼頭秀樹 and Yuishin Izumi : 病院連携により病理解剖を行った筋萎縮性側索硬化症の1例, 第108回日本神経学会中国・四国地方会, Dec. 2020.
27.	花田健太, Yusuke Osaki, 福本竜也, Naoko Matsui, Yuishin Izumi and 浦岡秀行 : 初期に頭部画像病変を欠くCISが先行し，10年後に診断された多発性硬化症の一例, 第61回日本神経学会学術大会, Aug. 2020.
28.	Yusuke Osaki, Wataru Sako, Shotaroh Haji, Nagahisa Murakami, Naoko Matsui and Yuishin Izumi : 傍腫瘍性視神経脊髄炎関連疾患(NMOSD)の高齢男性例, 第61回日本神経学会学術大会, Aug. 2020.
29.	Ryosuke Miyamoto, 黒田一駿, Hideo Mure, Ryoma Morigaki, Masahito Nakataki, Yusuke Osaki, Yuishin Izumi, Satoshi Goto and Ryuji Kaji : 18p-症候群に伴う全身性ジストニアに対し，GPi-DBSが効果的であった一例, 第61回日本神経学会学術大会, Aug. 2020.
30.	Hiroki Yamazaki, 高松直子, 福島功士, 三宅晶子, 垂髪祐樹, Takeshi Yoshida, Yusuke Osaki, 森敦子, Hiroyuki Nodera and Yuishin Izumi : 手指の痺れを主訴とした患者に対しどこまで対応するか, 第38回日本脳神経超音波学会総会, Jun. 2019.
31.	Yusuke Osaki : 神経核内封入体病の末梢神経興奮特性, 第60回日本神経学会学術大会, May 2019.
32.	原田紗希, Mayo Kondou, 西村春佳, Nobuhito Naito, Hiroshi Kawano, Yusuke Osaki, Yoshimi Bando, Naoki Takahashi, Kozo Kagawa, Yasuhiko Nishioka, Hirokazu Ogino, Makoto Tobiume, Atsuro Saijo, Hiroshi Nokihara, Yuko Toyoda, Masahiko Azuma, Hisatsugu Goto, Hisanori Uehara and Yasuhiko Nishioka : 傍腫瘍性神経症候群を合併した小細胞肺癌の一例, 第60回日本呼吸器学会中国・四国地方会, Dec. 2018.
33.	福本竜也, Ryosuke Miyamoto, 山﨑博輝, 村上永尚, Yusuke Osaki, Koji Fujita, Hiroyuki Nodera, Toshitaka Kawarai, Yuishin Izumi and Ryuji Kaji : 特異な歩行障害を呈したGerstmann-Straussler-Scheinker病の31歳男性, 第105回日本神経学会中国・四国地方会, Dec. 2018.
34.	高松直子, Hiroyuki Nodera, Toshitaka Kawarai, 山崎博輝, 森敦子, Yusuke Osaki, 垂髪祐樹, Yuishin Izumi and Ryuji Kaji : -PMP221, 第48回日本臨床神経生理学会学術大会, Nov. 2018.
35.	山上紘規, Sumiko Yoshida, 遠藤ふうり, 原倫世, 筒井康継, 桝田志保, Kiyoe Kurahashi, 明比祐子, Itsuro Endo, Ken-ichi Aihara, Yusuke Osaki, Ryuji Kaji, Yuichi Takashi, Masahiro Abe and Seiji Fukumoto : 壊死性ミオパチーを合併したX連鎖性低リン血症性くる病・骨軟化症の一例, 第18回日本内分泌学会四国支部学術集会, Sep. 2018.
36.	Hanada Kenta, Naoko Matsui, Hiroyuki Nodera, Kuzume Daisuke, Kenta Sato, Iwasa Naoki, Unai Yuki, Saka Waka, Yoshimichi Miyazaki, Yamazaki Hiroki, Yusuke Osaki, Takahiro Furukawa, Yamasaki Masahiro, Yuishin Izumi, Kusunoki Susumu, Kokichi Arisawa and Ryuji Kaji : Guillain-Barre syndrome in a local area in Japan, 2006-2015: An epidemiological and clinical study of 108 patients, XX World Congress of Neurology, Sep. 2017.

Et cetera, Workshop:

1.	Naoko Matsui, Yusuke Osaki, 西野一三, 山下賢 and Yuishin Izumi : 封入体筋炎における抗NT5C1A抗体と臨床像:当院症例について, 稀少難治性筋疾患に関する調査研究班「IBM分科会」(令和元年度) 東北大学医学部星陵会館大会議室, Jan. 2020.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Neuromuscular imaging study be optic coherence tomography (OCT) (Project/Area Number: 25670421 )
Search by Researcher Number (60645381)

Assistant Professor : Osaki, Yusuke

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)