Tokushima University / Educator and Researcher Directory --- Yamashita, Michiko

Personal Web Page

https://www.tokushima-u.ac.jp/med/health_science/course/keitai_kensa/pathological-analysis/

Field of Study

○	Clinical Pathology
○	Medical Education

Subject of Study

○	Relationship between bone narrow pathology and laboratory medicine (gelatinous degeneration of Bone marrow, CAR cell, laboratory data)
○	Medical education using Autopsy cases and Reversed clinicopathological conference (workshop, Clinicopathological conference (CPC), Reversed clinicopathological conference (RCPC), Autopsy)

Book / Paper

Book:

1.	Yasuharu Sato, Kengo Takeuchi and Michiko Yamashita : systemic lupus erythematosus lymphadenopathy. Non-neoplastic disease pathology atlas, 文光堂, Tokyo, Apr. 2023.

Academic Paper (Judged Full Paper):

1.	Tamaki Ohtani, Hitoshi Ikushima, Yoshimi Bando, Michiko Yamashita, Kenmei Kuwahara, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi : Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT, The Journal of Medical Investigation : JMI, Vol.70, No.3,4, 361-368, 2023. (Summary) This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023. (Keyword) Humans / Mice / Animals / Carcinoma, Non-Small-Cell Lung / Fluorodeoxyglucose F18 / Positron Emission Tomography Computed Tomography / Lung Neoplasms / Radiopharmaceuticals / Positron-Emission Tomography (Tokushima University Institutional Repository) ● Metadata: 118771 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.361 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940520 ● Search Scopus @ Elsevier (PMID): 37940520 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.361 (Tokushima University Institutional Repository: 118771, DOI: 10.2152/jmi.70.361, PubMed: 37940520)
2.	Riho Kageji, Yasutoshi Hida, Tomoko Hara, Michiko Yamashita, Kana Sakamoto and Kengo Takeuchi : Effectiveness of radiation therapy for skin lesions of blastic plasmacytoid dendritic cell neoplasm: A case report., Journal of the Japan Organization of Clinical Dermatologists, Vol.39, No.4, 562-566, 2022. (Keyword) blastic plasmacytoid dendritic cell neoplasm / BPDCN / radiation therapy
3.	Mayuko Shimizu, Yosuke Tsuchiyama, Yuki Morimoto, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Takeshi Oya, Hirohisa Ogawa, Michiko Yamashita, Satoru Matsuda, Katsuhisa Omagari, Shu Taira and Koichi Tsuneyama : A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages, The American Journal of Pathology, Vol.192, No.1, 31-42, 2022. (Summary) Various cells, such as macrophages and hepatic stellate cells, interact in the generation of fibrosis in nonalcoholic steatohepatitis (NASH), but the mechanism remains unclear. We employed a high-fat/cholesterol/cholate (HFCC) diet to generate a model of NASH-related fibrosis and investigate the pathogenesis of fibrosis. Two mouse strains differing in susceptibility to obesity, the susceptible strain C57BL/6J and the relatively resistant strain A/J, developed hepatic histologic features of NASH, including fat deposition, intralobular inflammation, hepatocyte ballooning, and fibrosis, after 9 weeks of HFCC diet feeding. The severity of hepatic inflammation and fibrosis was greater in A/J mice than in C57BL/6J mice. A/J mice fed the HFCC diet exhibited characteristic CD204-positive lipid-laden macrophage aggregation in hepatic parenchyma. Polarized light visualized the Maltese cross (namely, cholesterol crystals within the aggregated macrophages). Moreover, fibrosis developed in a ring shape from the periphery of the aggregated macrophages (ie, the starting point of fibrosis could be visualized histologically). Furthermore, matrix-assisted laser desorption/ionization mass spectrometry imaging analysis detected a molecule at m/z 772.462, which corresponds to the protonated ion of phosphatidylcholine [P-18:1 (11Z)/18:0] and phosphatidylethanolamine [18:0/20:2 (11Z, 14Z)], in aggregated macrophages adjacent to the fibrotic lesions. In conclusion, the present HFCC diet-fed A/J model provides an ideal tool to study fibrogenesis and enables novel insights into the pathophysiology of NASH-related fibrosis. (Keyword) Liver fibrosis / macrophage / animal model / cholesterol / cholate (Tokushima University Institutional Repository) ● Metadata: 116411 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ajpath.2021.10.002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34710382 ● Search Scopus @ Elsevier (PMID): 34710382 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajpath.2021.10.002 (Tokushima University Institutional Repository: 116411, DOI: 10.1016/j.ajpath.2021.10.002, PubMed: 34710382)
4.	Tomoko Kobayashi, Mayuko Shimizu, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Yuki Morimoto, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Chunmei Cheng and Koichi Tsuneyama : Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet., Pathology, Research and Practice, Vol.225, No.153559, 2021. (Summary) Although diabetes mellitus (DM) is a well-known risk factor for hepatocellular carcinoma (HCC), the underlying mechanisms have not yet to be defined. We previously reported that DIAR mice fed with standard murine diet developed type 1 diabetes and HCC at age of 16 weeks old with a neonatal streptozotocin treatment (n-STZ). Because DIAR mice did not manifest obesity nor develop steatohepatitis, hyperglycemia with streptozotocin trigger or streptozotocin alone might turn on the hepato-carcinogenesis. An insulin-recruitment to DIAR-nSTZ mice showed an increased frequency of HCC during the first 12 weeks of age, although the diabetic indications notably improved. To elucidate the role of hyperglycemia in hepato-carcinogenesis, we performed a head-to-head comparative study by using 4CS mice and DIAR mice with n-STZ treatment. Newborn 4CS mice and DIAR mice were divided into STZ treated group and control group. The blood glucose levels of DIAR-nSTZ mice increased at age of eight weeks, while that of 4CS-nSTZ mice were maintained in the normal range. At eight weeks old, three out of five DIAR-nSTZ mice (60%) and one out of ten 4CS-nSTZ mice (10%) developed multiple liver tumors. At age of 12 weeks old, all eight of DIAR-nSTZ mice (100%) and two of 10 4CS-nSTZ mice (20%) developed multiple liver tumors. At 16 weeks old, all animals of DIAR-nSTZ and 4CS-nSTZ mice occurred liver tumors. DIAR-nSTZ showed hyperglycemia and HCC, and 4CS-nSTZ developed HCC without hyperglycemia. These results were interpreted that the onset of HCC maybe not related to the presence or absence of hyperglycemia but nSTZ treatment. On the other hand, since the carcinogenesis of 4CS-nSTZ is delayed compared to DIAR-nSTZ, hyperglycemia may play a role in the progression of carcinogenesis. Histologically, the liver tumor appeared irregularly trabecular arrangements of hepatocytes with various degrees of nuclear atypia. By immunohistochemical analyses, all liver tumors showed positive staining of glutamine synthetase (GS), an established human HCC marker. The expression pattern of GS was divided into a strong diffuse pattern and weak patchy pattern, respectively. The liver tumor showing the weak GS-patchy pattern expressed biliary/stem markers, EpCAM, and SALL4, partially. Because 4CS-nSTZ mice did not show any metabolic complications such as gaining body weight or high blood glucose level, it is a unique animal model with a simple condition to investigate hepatic carcinogenesis by excluding other factors. (Tokushima University Institutional Repository) ● Metadata: 118286 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.prp.2021.153559 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34325313 ● Search Scopus @ Elsevier (PMID): 34325313 ● Search Scopus @ Elsevier (DOI): 10.1016/j.prp.2021.153559 (Tokushima University Institutional Repository: 118286, DOI: 10.1016/j.prp.2021.153559, PubMed: 34325313)
5.	Yuki Morimoto, Takeshi Oya, Mayuko Shimizu, Minoru Matsumoto, Hirohisa Ogawa, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Chunmei Cheng and Koichi Tsuneyama : Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells., Acta Cytologica, Vol.65, No.5, 430-439, 2021. (Summary) PESI-MS presented a promising potential as a novel diagnostic modality for swiftly acquiring specific cytological information. (Tokushima University Institutional Repository) ● Metadata: 116345 (Link to Publication Site) ● Publication site (DOI): 10.1159/000516639 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34098551 ● Search Scopus @ Elsevier (PMID): 34098551 ● Search Scopus @ Elsevier (DOI): 10.1159/000516639 (Tokushima University Institutional Repository: 116345, DOI: 10.1159/000516639, PubMed: 34098551)
6.	Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Izawa-Ishizawa Yuki, Licht Miyamoto, Ishizawa Keisuke, Hiromichi Fujino, Toshiaki Tamaki, Ken-ichi Aihara and Koichiro Tsuchiya : Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity, Kidney International, Vol.99, No.4, 885-889, 2021. (Summary) Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is currently available. Here, based on a repositioning analysis of the Food and Drug Administration Adverse Events Reporting System, we found that a previously developed drug, diphenhydramine, may provide a novel treatment for cisplatin-induced kidney toxicity. To confirm this, the actual efficacy of diphenhydramine was evaluated in in vitro and in vivo experiments. Diphenhydramine inhibited cisplatin-induced cell death in kidney proximal tubular cells. Mice administered cisplatin developed kidney injury with significant dysfunction (mean plasma creatinine: 0.43 vs 0.15 mg/dl) and showed augmented oxidative stress, increased apoptosis, elevated inflammatory cytokines, and MAPKs activation. However, most of these symptoms were suppressed by treatment with diphenhydramine. Furthermore, the concentration of cisplatin in the kidney was significantly attenuated in diphenhydramine-treated mice (mean platinum content: 70.0 vs 53.4 μg/g dry kidney weight). Importantly, diphenhydramine did not influence or interfere with the anti-tumor effect of cisplatin in any of the in vitro or in vivo experiments. In a selected cohort of 98 1:1 matched patients from a retrospective database of 1467 patients showed that patients with malignant cancer who had used diphenhydramine before cisplatin treatment exhibited significantly less acute kidney injury compared to ones who did not (6.1 % vs 22.4 %, respectively). Thus, diphenhydramine demonstrated efficacy as a novel preventive medicine against cisplatin-induced kidney toxicity. (Tokushima University Institutional Repository) ● Metadata: 115399 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.kint.2020.10.041 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33307103 ● Search Scopus @ Elsevier (PMID): 33307103 ● Search Scopus @ Elsevier (DOI): 10.1016/j.kint.2020.10.041 (Tokushima University Institutional Repository: 115399, DOI: 10.1016/j.kint.2020.10.041, PubMed: 33307103)
7.	Mayuko Shimizu, Katsuhisa Omagari, Michiko Yamashita and Koichi Tsuneyama : Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis., Bioscience, Biotechnology, and Biochemistry, Vol.85, No.4, 941-947, 2021. (Summary) Nonalcoholic steatohepatitis (NASH) progresses to liver fibrosis and cirrhosis. Existing mouse models of NASH rarely develop diet-induced severe fibrosis. We aimed to establish a dietary model of NASH with rapid progression to fibrosis. Six-week-old male Tsumura-Suzuki obese diabetes (TSOD) mice (a model of spontaneous metabolic syndrome) and corresponding control Tsumura-Suzuki nonobese (TSNO) mice were fed a novel diet high in fat, cholesterol, and cholate (iHFC). Histologic steatohepatitis, including steatosis, inflammation, and fibrosis, were observed in both TSNO and TSOD iHFC diet-fed mice at 20 weeks of age. As compared with TSOD mice, TSNO mice developed much more severe fibrosis and reached stage 3 of bridging fibrosis within 14 weeks under the iHFC diet feeding. Perivenular/perisinusoidal pattern of fibrosis in TSNO mice resembled human NASH. Our model of NASH with advanced fibrosis by simple diet offers many advantages useful in studying the mechanism of liver fibrosis and preclinical drug testing. (Link to Publication Site) ● Publication site (DOI): 10.1093/bbb/zbaa107 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33620426 ● Search Scopus @ Elsevier (PMID): 33620426 ● Search Scopus @ Elsevier (DOI): 10.1093/bbb/zbaa107 (DOI: 10.1093/bbb/zbaa107, PubMed: 33620426)
8.	Michiko Yamashita, Masahiko Nakasono, Joji Shunto, Naoto Kuroda and Takeshi Oya : A study about clinicopathological features of Japanese gastric Hamartomatous inverted polyp (inverted hyperplastic polyp) reported before 2002, Shikoku Acta Medica, Vol.76, No.1,2, 61-68, 2020. (Summary) Gastric hamartomatous inverted polyp (g-HIP) is rare gastric elevated lesion forming endophytic growth pattern which etiology remains unknown. G-HIP is said to be associated with gastric cancer and gastritis. We systematically reviewed Japanese g-HIP's clinicopathological features reported before2002. Japanese g-HIP amount to20lesions,18patients ; 7(38 9%)were males and 11(61 1%)were females. The mean age of patients was 60 2 years old. The mean size of the lesions was21 7millimeter. No of the polyp shape was Yamada type IV7, Yamada type I/flat elevation 6, Yamada type III 4 and Yamada II 3, respectively. The site of the lesions was Body11, Cardia3, Fornix3and Antrum1, respectively. In12described cases, accompanied lesion was Gastritis, Carcinoma, GCP, Hyperplastic polyp, GIST and remnant stomach due to ulcer. Of the submucosal shaped(Yamada type I/flat elevation)g-HIP,50% has GCP and62 5% has gastric cancer. The common feature of g-HIP was pyloric gland-like mucous gland proliferation and cystic dilatation in the H. pylori era of Japan. (Keyword) hamartomatous hyperplastic polyp / inverted hyperplastic polyp / stomach / gastritis cystica profunda / Helicobacter pylori (Tokushima University Institutional Repository) ● Metadata: 114857 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050566774761706624 (Tokushima University Institutional Repository: 114857, CiNii: 1050566774761706624)
9.	Osamu Mori, 富林敦司, Shohei Etoh, Yuta Matsuo, Takao Tsuneki, Hidenori Maki and Michiko Yamashita : 根治切除9年以上経過後に上縦隔リンパ節再発した食道癌の1例, Journal of Japan Surgical Association, Vol.81, No.1, 54-59, 2020. (Link to Publication Site) ● Publication site (DOI): 10.3919/jjsa.81.54 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390285300179534336 ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.81.54 (DOI: 10.3919/jjsa.81.54, CiNii: 1390285300179534336)
10.	Michiko Yamashita, Goto Tetsuya, Sei Nobuyuki, Fujii Yoshiyuki and Harukawa Jun-ichi : Extranodal Site and Aggressive Histological Subtype Lead to Undetectable Giemsa Banding in Lymphoid Tumors, The Official Journal of Japanese Society of Laboratory Medicine, Vol.67, No.10, 1011-1016, 2019. (Keyword) lymphnodebiopsy(リンパ節生検) / Giemsabanding:G-band(G分染法) / lymphoma(リンパ腫) / extranodal(節外性) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853834480717696 (CiNii: 1520853834480717696)
11.	Yoshihiro Matsudate, Michiko Yamashita, Yoshiyuki Fujii and Yoshio Urano : Contact granulomatous hypersensitivity to indium in a patient with orofacial granulomatosis., Contact Dermatitis, Vol.81, No.4, 293-294, 2019. (Keyword) Dental Amalgam / Granulomatosis, Orofacial / Humans / Hypersensitivity, Delayed / Indium / Lip Diseases / Patch Tests (Link to Publication Site) ● Publication site (DOI): 10.1111/cod.13284 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30957231 ● Search Scopus @ Elsevier (PMID): 30957231 ● Search Scopus @ Elsevier (DOI): 10.1111/cod.13284 (DOI: 10.1111/cod.13284, PubMed: 30957231)
12.	Masakazu Goto, Hiroshi Okitsu, Yasuhiro Yuasa, Yuta Matsuo, Hiroshi Edagawa, Ryotaro Tani, Osamu Mori, Shunsuke Kuramoto, Atsushi Tomibayashi, Michiko Yamashita and Yoshiyuki Fujii : [A Case of Complete Pathological Response in a Patient with Locally Advanced Sigmoid Colon Cancer after FOLFOX IRI Chemotherapy]., Japanese Journal of Cancer and Chemotherapy, Vol.42, No.11, 1431-1434, 2015. (Summary) A 61-year-old man with advanced sigmoid colon cancer was admitted to our hospital. Abdominal computed tomography (CT) revealed locally advanced sigmoid colon cancer, with suspected invasion of the bladder and small intestine. The clinical stage of the disease was T4b, N1, M0, and Stage III a, with wild-type KRAS expression. A transverse colostomy was performed because of the presence of a bowel obstruction. The patient received 4 courses of Leucovorin, 5-fluorouracil, oxaliplatin, and irinotecan (FOLFOXIRI). The size of the tumor and lymph nodes decreased noticeably after chemotherapy and laparoscopic high anterior resection with lymph node dissection. During this phase, the pathological stage of the disease was ypT0, N0, and Stage 0(no viable carcinoma cells, Grade 3). This result suggested that preoperative FOLFOXIRI chemotherapy is a useful regimen for the treatment of locally advanced colon cancer. (Keyword) Antineoplastic Combined Chemotherapy Protocols / Biopsy / Combined Modality Therapy / Humans / Male / Middle Aged / Neoplasm Staging / Sigmoid Neoplasms / Tomography, X-Ray Computed (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26602406 ● Search Scopus @ Elsevier (PMID): 26602406 (PubMed: 26602406)
13.	Michiko Yamashita, Yoshiyuki Fujii, Keiji Ozaki, Yoshio Urano, Masami Iwasa, Shingen Nakamura, Shiroh Fujii, Masahiro Abe, Yasuharu Sato and Tadashi Yoshino : Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma., Diagnostic Pathology, Vol.10, 185, 2015. (Summary) Malignant syphilis or lues maligna is a severe form of secondary syphilis that was commonly reported in the pre-antibiotic era, and has now reemerged with the advent of the human immunodeficiency virus (HIV) epidemic. However, the characteristic histopathological findings of malignant syphilis remain controversial. The aim of this case report was to clarify the clinical and histopathological findings of HIV-positive malignant secondary syphilis. A Japanese man in his forties complained of fever, skin lesions, headache, and myalgia without lymphadenopathy during the previous 4 weeks. The skin lesions manifested as erythematous, nonhealing, ulcerated papules scattered on his trunk, extremities, palm, and face. Although the skin lesions were suspected to be cutaneous T-cell lymphomas on histological analyses, they lacked T-cell receptor Jγ rearrangement; moreover, immunohistochemical analyses confirmed the presence of spirochetes. The patient was administered antibiotics and anti-retroviral therapy, which dramatically improved the symptoms. On the basis of these observations of the skin lesions, we finally diagnosed the patient with HIV-associated secondary syphilis that mimicked cutaneous T-cell lymphoma. The patient's systemic CD4+ lymphocyte count was very low, and the infiltrate was almost exclusively composed of CD8+ atypical lymphocytes; therefore, the condition was easily misdiagnosed as cutaneous lymphoma. Although the abundance of plasma cells is a good indicator of malignant syphilis on skin histological analyses, in some cases, the plasma cell count may be very low. Therefore, a diagnosis of malignant secondary syphilis should be considered before making a diagnosis of primary cutaneous peripheral T-cell lymphoma or lymphoma associated with HIV infection. (Keyword) AIDS-Related Opportunistic Infections / Anti-Bacterial Agents / Anti-HIV Agents / Biopsy / Coinfection / Diagnosis, Differential / HIV Infections / Humans / immunohistochemistry / Lymphoma, T-Cell, Cutaneous / male / Predictive Value of Tests / skin / Skin Neoplasms / Syphilis / Syphilis, Cutaneous / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1186/s13000-015-0419-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26449225 ● Summary page in Scopus @ Elsevier: 2-s2.0-84943540407 (DOI: 10.1186/s13000-015-0419-5, PubMed: 26449225, Elsevier: Scopus)
14.	Taniguchi Chihiro, Yoshihiro Matsudate, Sakurayama Yuko, Michiko Yamashita and Urano Yoshio : 妊娠前期に発症したStevens-Johnson症候群の1例, Hifuka No Rinsho, Vol.56, No.9, 1319-1323, 2014. (Keyword) Stevens-Johnson症候群 / 妊婦 / アセトアミノフェン / 塩酸セフカペンピボキシル (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521417754959986688 (CiNii: 1521417754959986688)
15.	Seiichi Nakano, Hironori Akizuki, Hidetaka Iwasaki, Michiko Yamashita, Yoshiyuki Fujii, Eiji Kondo, Haruhiko Shizuku, Koichi Tamura and Noriaki Takeda : A Case of a Laryngocele with Recurrent Infection, Practica Oto-Rhino-Laryngologica, Vol.106, No.5, 439-445, 2013. (Summary) We report herein on a case of laryngocele with recurrent infection. A 48-year-old male complained of hoarseness and swelling of the left side of his neck. The endoscopic and CT scan examinations demonstrated the combined type of laryngocele that had expanded through the thyrohyoid membrane and had swollen up both medially and laterally in a dumbbell-like shape. To avoid the risk of laryngeal stenosis with the enlarged laryngocele infected by bacteria, in addition to intravenous infusion of an anti-bacterial drug, purulent discharge was drained from the infected laryngocele with a puncture needle. Because infection of the laryngocele was recurrent, it was surgically removed via an external neck approach under general anesthesia without any prophylactic tracheotomy. The laryngocele may be translated from a saccular cyst that had developed after the obstruction of communication between the laryngeal ventricle and the laryngeal saccule. (Keyword) laryngocele / saccular cyst / laryngeal ventricle / laryngeal saccule / laryngopyocele (Link to Publication Site) ● Publication site (DOI): 10.5631/jibirin.106.439 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204273025280 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878023452 (DOI: 10.5631/jibirin.106.439, CiNii: 1390001204273025280, Elsevier: Scopus)
16.	Tomomi MORIKAWA, Misa IWASA, Mako MINATO, Kaori IGATA, Emi MURAZAWA, Michiko Yamashita, Atsushi KURUSHIMA and Yoshiaki FUKUMURA : A case of native valve endocarditis caused by Staphylococcus lugdunensis, Japanese Journal of Medical Technology, Vol.59, No.7, 847-851, 2010. (Keyword) Staphylococcus lugdunensis / Infective endocarditis / native valve endocarditis / CNS (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572824501048452864 (CiNii: 1572824501048452864)
17.	Takeshi Iwasa, Anna Tani, Yuka Miyatani, Shirou Bekku, Michiko Yamashita, Kazuyo Nakanishi, Yoshiyuki Fujii and Hiroyasu Ino : Lymphangioma of the ovary accompanied by chylous ascites., The Journal of Obstetrics and Gynaecology Research, Vol.35, No.4, 812-815, 2009. (Summary) Lymphangioma of the ovary is very rare, with only 17 cases reported to date. In this report, a 43-year-old woman with lymphangioma of the ovary accompanied by chylous ascites is described. Vaginal ultrasound showed a solid cystic tumor at the right ovary accompanied by ascites. The volume of ascites was changeable. Milky fluid obtained by Douglas pouch aspiration contained numerous mature lymphocytes. She underwent right salpingo-oophorectomy. Histological examination revealed that the excised tumor from the right ovary was consistent with benign lymphangioma. This is the first case report of lymphangioma of the ovary accompanied by chylous ascites. We should discriminate such cases from other malignant tumors in order to avoid overtreatment. (Keyword) Adult / Chylous Ascites / Female / Humans / Lymphangioma / Ovarian Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1447-0756.2009.01016.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19751350 ● CiNii @ National Institute of Informatics (CRID): 1570854175897531520 ● Summary page in Scopus @ Elsevier: 2-s2.0-70049094210 (DOI: 10.1111/j.1447-0756.2009.01016.x, PubMed: 19751350, CiNii: 1570854175897531520, Elsevier: Scopus)
18.	Kazuhisa Katayama, Hiroshi Okitsu, Suguru Kimura, Tomoko Hara, Keiji Ozaki, Tetsuya Goto, Michiko Yamashita and Yoshiyuki Fujii : [A case of disseminated bone marrow carcinosis with disseminated intravascular coagulation successfully controlled with S-1 after total gastrectomy for advanced gastric cancer]., Japanese Journal of Cancer and Chemotherapy, Vol.35, No.7, 1201-1204, 2008. (Summary) Bone marrow carcinosis due to gastric cancer with disseminated intravascular coagulation(DIC)occurs suddenly, progresses rapidly, and has a very poor prognosis. In addition, physical status tends to be bad at the time of the episode, and palliative care is generally selected as the treatment method. The case was a 70-year-old woman who underwent total gastrectomy for scirrhous stomach cancer five years previously. She recently noticed gingival hemorrhage, and was referred to our hospital by a nearby doctor. As a result of her examination, she was diagnosed with disseminated bone marrow carcinosis as a postoperative recurrence of gastric cancer that resulted in DIC. We transfused blood platelets and fresh frozen plasma into her, and controlled the bleeding tendency temporarily. She was started on oral administration of S-1 for improvement of DIC, and the therapy was successful without loss of QOL. It is easy to continue S-1 therapy as chemotherapy in the outpatient department, because it is a matter of internal medicine. (Keyword) Aged / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Biopsy / Bone Marrow Neoplasms / Disseminated Intravascular Coagulation / Drug Combinations / female / Gastrectomy / Humans / Oxonic Acid / Radionuclide Imaging / Stomach Neoplasms / Tegafur / Tomography, X-Ray Computed (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18633263 ● Search Scopus @ Elsevier (PMID): 18633263 (PubMed: 18633263)
19.	Michiko Yamashita, Toshiaki Sano, Zhi-Rong Qian, Kalman Kovacs and Eva Horvath : Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association., Endocrine Pathology, Vol.17, No.2, 155-164, 2006. (Summary) Horvath et al. called relatively small ACTH-immunoreactive (ACTH-IR) cells observed in basophil invasion "proopiomelanocortin (POMC) cells," and these cells were supposed to be different from larger ACTH-IR cells in human adenohypophysis. To clarify the existence of "anterior POMC cells," we examined 21 autopsy cases taking note of follicular cells (FCs). We found that smaller ACTH-IR cells were clustered forming small areas without FC association, clustered small cell island (CSCI). CSCI was found in all the specimens we examined using immunohistochemical staining for ACTH and cytokeratin (AE1/AE3) in serial sections. ACTH-IR cells outside CSCI were of various sizes, mainly consisting of larger ACTH-IR cells that were diffusely scattered among other hormone-secreting cells and closely associated with FCs. By immunohistochemistry, ACTH-IR cells within CSCI and basophil invasion showed uniformly weak reactivity and common patterns for cytokeratins (CAM5.2 and 35 beta H11), carboxypeptidase D, and LeuM1, whereas those outside CSCI showed a great variety of immunoreactivity. The similarity in the immunoreactivity of ACTH-IR cells between CSCI and basophil invasion suggests that ACTH-IR cells in these two areas have common characteristics and ACTH-IR cells in CSCI are most likely "POMC cells." The clustered "anterior POMC cells" may be distinguishable by light microscopic immunohistochemistry. (Keyword) Adrenocorticotropic Hormone / Aged / Basophils / female / Humans / immunohistochemistry / male / Middle Aged / Pituitary Gland, Anterior / Pro-Opiomelanocortin (Link to Publication Site) ● Publication site (DOI): 10.1385/EP:17:2:155 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17159248 ● Search Scopus @ Elsevier (PMID): 17159248 ● Search Scopus @ Elsevier (DOI): 10.1385/EP:17:2:155 (DOI: 10.1385/EP:17:2:155, PubMed: 17159248)
20.	Michiko Yamashita, Zhi-Rong Qian, Toshiaki Sano, Eva Horvath and Kalman Kovacs : immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis., Pathology International, Vol.55, No.5, 244-247, 2005. (Summary) Non-hormone-secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S-100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S-100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type ('CK-type cell') was cells weakly positive for S-100 protein in the nucleus and for CK-immunoreactivity in the cytoplasm. The next numerous type ('S-100 protein cell') was cells strongly positive for S-100 protein and weakly positive or negative for CK. The CK-type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone -immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S-100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so-called stellate cells. GFAP-positive cells were rare. It is implied that S-100 protein-positive FSC could be divided into at least two main subtypes: FC (CK-type cells) and stellate cells (S-100 protein cells). (Keyword) Adrenocorticotropic Hormone / Female / Glial Fibrillary Acidic Protein / Humans / Immunohistochemistry / Keratins / Male / Middle Aged / Pituitary Gland, Anterior / S100 Proteins (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1440-1827.2005.01820.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15871721 ● Search Scopus @ Elsevier (PMID): 15871721 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-1827.2005.01820.x (DOI: 10.1111/j.1440-1827.2005.01820.x, PubMed: 15871721)
21.	Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Yasumasa Ikeda, Michiko Yamashita, Toshiki Sudo, Hideki Hayashi, Yoshihisa Yamada, Fuminari Endoh, Mitsunori Fujimura, Tomonori Yoshida, Hiroshi Yamaguchi, Shunji Hashizume, Midori Kato, Kimihiro Yoshimura, Yoko Yamamoto, Shigeaki Kato and Toshio Matsumoto : Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice, The Journal of Biological Chemistry, Vol.279, No.34, 35798-35802, 2004. (Summary) Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis, cell differentiation, and regulation of the immune system. Expression of these genes is mediated by the activation of the nuclear vitamin D receptor (VDR). Previous studies have shown that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, exerts anticoagulant effects in cultured monocytic cells. To clarify whether activation of VDR plays any antithrombotic actions in vivo, hemostatic/thrombogenic systems were examined in normocalcemic VDR knock-out (KO) mice on a high calcium diet and compared with wild type and hypocalcemic VDRKO mice that were fed a regular diet. Platelet aggregation was enhanced significantly in normocalcemic VDRKO mice compared with wild type and hypocalcemic VDRKO mice. Aortic endothelial nitric-oxide (NO) synthase expression and urinary NOx excretions were reduced in hypocalcemic VDRKO mice, but not in normocalcemic VDRKO mice. Northern blot and RT-PCR analyses revealed that the gene expression of antithrombin in the liver as well as that of thrombomodulin in the aorta, liver and kidney was down-regulated in hypo- and normocalcemic VDRKO mice. Whereas tissue factor mRNA expression in the liver and kidney was up-regulated in VDRKO mice regardless of plasma calcium level. Furthermore, VDRKO mice manifested an exacerbated multi-organ thrombus formation after exogenous lipopolysaccharide injection regardless of the calcemic conditions. These results demonstrate that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggest that the VDR system may play a physiological role in the maintenance of antithrombotic homeostasis. (Keyword) FILTRATION PRESSURE METHOD / TISSUE-FACTOR / 1,25-DIHYDROXYVITAMIN D-3 / ANTITHROMBIN DEFICIENCY / WHOLE-BLOOD / EXPRESSION / cells / AGGREGATION / inhibition / ALOPECIA (Link to Publication Site) ● Publication site (DOI): 10.1074/jbc.M404865200 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15205460 ● CiNii @ National Institute of Informatics (CRID): 1362262945661168512 ● Summary page in Scopus @ Elsevier: 2-s2.0-4143096123 (DOI: 10.1074/jbc.M404865200, PubMed: 15205460, CiNii: 1362262945661168512, Elsevier: Scopus)
22.	Hideko Endo, Mitsuyoshi Hirokawa, Naozumi Ishimaru, Yasushi Tanaka, Michiko Yamashita, Mika Sakaki, Yoshio Hayashi and Toshiaki Sano : Unique cell membrane expression if topoisomerase-ll alpha as a useful diagnostic marker of liposarcoma, Pathology International, Vol.54, No.3, 145-150, 2004. (Summary) Topoisomerase-II alpha (Topo-II alpha) is known as a cell cycle-related intranuclear marker. To the best of our knowledge, the expression of Topo-II alpha on extranuclear sites has not been reported. The aim of the present study was to determine the usefulness of Topo-II alpha immunostaining for detecting the lipoblasts that are essential to diagnosing liposarcoma. Surgical specimens, including benign lipomatous tumors (four cases), well-differentiated liposarcomas (three cases), myxoid liposarcomas (six cases), pleomorphic liposarcomas (two cases), dedifferentiated liposarcomas (two cases), myxoid malignant fibrous histiocytomas (six cases), and one case of mesenteric panniculitis, were studied. Samples were immunostained using antibodies for Topo-II alpha, S-100 protein and Ki-67. In addition, we used the western blot method to investigate immunohistochemical-affinity in adipocytes. Mature adipocytes and lipoblasts in all of the benign and malignant lipomatous tumors intensively expressed cell contours positivity for Topo-II alpha. Cytoplasm of the lipoblasts occasionally reacted to the antibody and highlighted intracytoplasmic small unilocular, multivacuolated, or bubble-like patterns. Western blot analysis confirmed a 70 kDa product reactive to Topo-II alpha in the cell membrane fragment of mature adipocytes. S-100 protein expressed adipocytes and lipoblasts, but the detection of lipoblasts was not as easy as in Topo-II alpha immunostaining. Immunoreactivity of Ki-67 was limited to the nuclei, and the nuclear labeling index of Ki-67 correlated with that of Topo-II alpha. The immunoreactivity of Topo-II alpha for lipoblasts was more sensitive and obvious than those of S-100 protein. Immunostaining using the antibody for Topo-II alpha seems to be useful in recognizing lipoblasts that have been overlooked in hematoxylin-eosin-stained preparations, and is a useful marker for diagnosing liposarcoma. (Keyword) adipocytes / lipoblasts / liposarcoma / malignant fibrous histiocytoma / S-100 protein / topoisomerase-ll alpha (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1440-1827.2003.01600.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14989736 ● Search Scopus @ Elsevier (PMID): 14989736 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-1827.2003.01600.x (DOI: 10.1111/j.1440-1827.2003.01600.x, PubMed: 14989736)
23.	Michiko Yamashita, Mitsuyoshi Hirokawa, Masahiko Nakasone, Hiroshi Kiyoku, Nobuya Sano, Masahiko Fujii, Takashi Koyama, Sadahiro Yoshida and Toshiaki Sano : Gastric inverted hyperplastic polyp. Report of four cases and relation to gastritis cystica profunda, APMIS, Vol.110, No.10, 717-723, 2002. (Summary) Gastric inverted hyperplastic polyp (IHP) is a rare type of gastric polyp, and is characterized by downward growth of the hyperplastic mucosal components into the submucosa. To the best ofour knowledge, 16 gastric IHP cases have been described in the English literature, but the pathogenesis has not been established. We report the clinical and pathological findings of four gastric IHP cases. The lesions were mainly composed of hyperplastic foveolar-type glands with focal cystic dilatation. Pyloric type glands, endocrine cells, acinic cell metaplasia, and smooth muscle bundles were also seen as components of the polyp. Two cases (cases 1 and 4) coexisted with multifocal gastritis cystica profunda (GCP) and gastric adenocarcinoma. Case 4 furthermore exhibited an intermediate form between IHP and GCP. We suggest that IHP may be GCP associated with exaggeratedly hyperplastic and metaplastic changes. In case 4, the coexisting gastric carcinoma was mainly located in the submucosa, whilst the mucosal component was minimal. Five out of twenty reported gastric IHP cases, including our cases, coexisted with gastric adenocarcinoma. These facts would lead us to further investigate the relation between gastric IHP and carcinoma. (Keyword) Stomach / inverted / hyperplastic polyp / gastritis cystica profunda (Link to Publication Site) ● Publication site (DOI): 10.1034/j.1600-0463.2002.1101005.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12583438 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036819086 (DOI: 10.1034/j.1600-0463.2002.1101005.x, PubMed: 12583438, Elsevier: Scopus)
24.	Michiko Yamashita, Mitsuyoshi Hirokawa, Toshiaki Sano and 蔭山武文 : 二次的変性を伴った側頭骨軟骨芽細胞腫の1例, 診断病理, Vol.19, No.1, 11-14, 2002. (Keyword) chondroblastoma / temporal bone / S-100 protein / aneurysmal bone cyst / degeneration
25.	Michiko Onishi, 広川満良, Chikako Takai, 山田順子, 三浦尚子, 古本博孝 and 佐野壽昭 : Diff-Quik染色が診断に有用であった卵巣好酸性明細胞腺癌の1例, 診断病理, Vol.18, No.2, 159-161, 2001. (Keyword) oxyphilic clear cell carcinoma / ovary / Diff-Quik stain / basement membrane / tigroid appearance
26.	Shingo Wakatsuki, Mitsuyoshi Hirokawa, Michiko Onishi, 矢和田裕子, Takanori Hirose and Toshiaki Sano : 偽血管腔がみられなかった血管腫様悪性線維組織球腫の1例, 診断病理, Vol.18, No.2, 197-199, 2001. (Keyword) soft tissue / angiomatoid malignant fibrous histiocytoma / pseudovascular space / desmin / CD99
27.	Hajime MAETA, Michiko Onishi, Ichiro ARIOKA, Setsuro IMAWAKI, Arifumi TAKAZAWA and Yoichi YAMASHITA : Ruptured Right Deep Femoral Aneurysm Concomitant with Aneurysm of Left Lateral Femoral Circumflex Artery, 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery, Vol.5, No.4, 605-609, 1996. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570291226104925824 (CiNii: 1570291226104925824)

Academic Paper (Unrefereed Paper):

1.	Miki Tomura, Hitoshi Shono, Hironori Akizuki, Michiko Yamashita and Fujii Yoshiyuki : Two cases of allergic fungal rhinosinusitis, Tokushima Red Cross Hospital Medical Journal, Vol.25, No.1, 37-43, 2020. (Keyword) アレルギー性真菌性副鼻腔炎 / 慢性副鼻腔炎 / 好酸球性副鼻腔炎 / allergic fungal rhinosinusitis / chronic sinusitis / eosinophilic sinusitis (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050003824755858688 (CiNii: 1050003824755858688)
2.	Yoko Akagawa, Hideki Otsuka, Norio Onishi, Hayato Tani, Naoto Uyama, Katsuya Takechi, Mitsuhiro Kinoshita, Kyosuke Osaki, Hirofumi Kekku, Naoko Ishibashi, Tomoko Hara, Kenji Ozaki, Tetsuya Goto, Michiko Yamashita and Hidehisa Horiguchi : A case of pulmonary intravascular large B-cell lymphoma evaluated by ¹⁸ F-FDG-PET/CT, Tokushima Red Cross Hospital Medical Journal, Vol.24, No.1, 66-72, 2019. (Keyword) ¹⁸ F-FDG-PET/CT / IVLBCL / 経気管支肺生検 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564288374020864 (CiNii: 1050564288374020864)
3.	Shunsuke Watanabe, Michiko Yamashita, Yoshiyuki Fujii, Yasutoshi Hida, Kensuke Sasaki and Takuya Seike : Verrucous carcinoma presenting with a histopathological variety : A case report, Tokushima Red Cross Hospital Medical Journal, Vol.24, No.1, 73-76, 2019. (Keyword) verrucous carcinoma / 好酸球浸潤 / 腫瘍関連組織好酸球増多 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282813397310848 (CiNii: 1050282813397310848)
4.	Saya Matsuzaki, Michiko Yamashita, Yoshiyuki Fujii, Mika Takashima, Hisashi Ishikura and Kenjiro Ushigoe : A case of choriocarcinoma developed four years after normal delivery, Tokushima Red Cross Hospital Medical Journal, Vol.23, No.1, 80-85, 2018. (Keyword) 絨毛癌 / 肺転移 / hCG / total hCG / 正常妊娠 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001338025101056 (CiNii: 1050001338025101056)
5.	Noriko Iwasa, Tomoko Hara, Hirofumi Bekku, Naoko Ishibashi, Keiji Ozaki, Tetsuya Goto, Michiko Yamashita and Yoshiyuki Fujii : Cytomegalovirus-associated gastric ulcers complicated by virus-associated hemophagocytic syndrome in a patient with rheumatoid arthritis under prolonged immunosuppression, Tokushima Red Cross Hospital Medical Journal, Vol.23, No.1, 67-73, 2018. (Keyword) rheumatoid arthritis / cytomegalovirus-associated gastric ulcer / virus-associated hemophagocytic syndrome (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282813001810816 (CiNii: 1050282813001810816)
6.	Nobuyuki Sei, Mitsuho Watanabe, Chihiro Itami, Haruka Tada, Toshio Shimizu, Misa Shimizu, Hisae Shono, Chikako Uenishi, Jun Hayami and Michiko Yamashita : Improving Turn-around Time(TAT)-A Fundamental Performance Analysis of Nanopia P-FDP & Nanopia D-dimer on the CS-2000 i, Tokushima Red Cross Hospital Medical Journal, Vol.22, No.1, 1-6, 2017. (Keyword) TAT(Turnaround Time) / FDP / D-dimer / Coagulation Assay Consensus (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287978427520 (CiNii: 1050564287978427520)
7.	Michiko Yamashita, Hiroshi Niki and Yoshio Urano : An ISO9001 based trial in the Department of Clinical Laboratory : Utilization and staff participation pertaining to the use of electronic medical record terminals, Tokushima Red Cross Hospital Medical Journal, Vol.21, No.1, 109-120, 2016. (Keyword) ISO15189 / ISO9001 / 臨床検査室 / 品質マネジメントシステム / 電子カルテ端末 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282813001716736 (CiNii: 1050282813001716736)
8.	Haruka Tada, Yoshika Maeda, Chikako Uenishi and Michiko Yamashita : Elevation of serum chloride due to continuous use of nonprescription sedatives : A case report, Tokushima Red Cross Hospital Medical Journal, Vol.20, No.1, 46-49, 2015. (Keyword) 偽性高クロール血症 / ブロム / 中毒
9.	Yuko Matsuda, Akiyo Ono, Kazuyo Nakanishi, Satoru Hatakeyama, Yuri Masuda, Yoshiyuki Fujii and Michiko Yamashita : A case of primary effusion lymphoma detected in the pericardial effusion of a HIV and HHV-8 negative patient, Tokushima Red Cross Hospital Medical Journal, Vol.20, No.1, 55-59, 2015. (Keyword) PEL / HHV-8 / cell-block
10.	久保田真理, 生越剛司, Tsutomu Watanabe, 富本亜由美, Rieko Kondo, 谷口多嘉子, 七條光市, 高橋昭良, 中津忠則, Michiko Yamashita and 木村聡 : A case of posterior reversible encephalopathy syndrome complicated by Epstein-Barr virus-hemophagocytic lymphohistiocytosis, Tokushima Red Cross Hospital Medical Journal, Vol.19, No.1, 99-102, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762952777344 (CiNii: 1050845762952777344)
11.	名護可容, Hiroyuki Furumoto, Eishi Sogawa, Riyo Kinouchi, Kenjiro Ushigoe, 別宮史朗, Michiko Yamashita and 藤井義幸 : A case of carcinosarcoma of the uterine cervix, 徳島赤十字病院医学雑誌, Vol.19, No.1, 70-75, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762952774272 (CiNii: 1050845762952774272)
12.	松枝崇, Tatsuo Motoki, 来島敦史, 大谷享史, 福村好晃, Michiko Yamashita and 藤井義幸 : 局所的な大動脈解離による外傷性大動脈閉鎖不全症に対する1手術例, Tokushima Red Cross Hospital Medical Journal, Vol.19, No.1, 95-98, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287976065664 (CiNii: 1050564287976065664)
13.	Yutaro Yamashita, Hiroaki Nagae, 藤井義幸 and Michiko Yamashita : 切除術より20年後に再発した足部の筋血管周皮腫の1例, Tokushima Red Cross Hospital Medical Journal, Vol.19, No.1, 49-51, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287976062208 (CiNii: 1050564287976062208)
14.	住友弘幸, Hiroshi Okitsu, 増田有理, 藏本俊輔, Daisuke Matsumoto, 富林敦司, 浜田陽子, Masakazu Goto, 湯浅康弘, 川中妙子, 石倉久嗣, 木村秀, 阪田章聖, Michiko Yamashita and 藤井義幸 : Epstein-Barr virus-positive gastric cancer with lymph node metastasis : a case report, Tokushima Red Cross Hospital Medical Journal, Vol.19, No.1, 44-48, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812999350400 (CiNii: 1050282812999350400)
15.	Daisuke Matsumoto, 木村秀, 石倉久嗣, 松岡裕, 増田有理, 藏本俊輔, 富林敦司, Masakazu Goto, 浜田陽子, 湯浅康弘, 川中妙子, Hiroshi Okitsu, 阪田章聖, Michiko Yamashita and 藤井義幸 : 長期間自然経過を追えた早期肺癌の1例, Tokushima Red Cross Hospital Medical Journal, Vol.19, No.1, 76-79, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001338022642304 (CiNii: 1050001338022642304)
16.	Naotsugu Murakami, Hiroki Inoue, Sayo Ueda, Kanako Nakauchi, Yu Miyai, Sunao Shimada, Yoshiko Kanezaki, Yasumi Shintani, Mio Machida, Yoshio Urano, Michiko Yamashita and Yoshiyuki Fujii : A Case of Destructive Thyroiditis Presenting with a Clinical Course Similar to Adult-onset Still's Disease, Tokushima Red Cross Hospital Medical Journal, Vol.18, No.1, 79-83, 2013. (Keyword) 成人スティル病 / 高フェリチン血症 / 破壊性甲状腺炎
17.	Takashi Hirai, Yoshio Urano, Chihiro Taniguchi, Mio Machida, Michiko Yamashita and Yoshiyuki Fujii : An Autopsy Case of Necrotizing Fasciitis Caused by Vibrio vulnificus, Tokushima Red Cross Hospital Medical Journal, Vol.18, No.1, 66-70, 2013. (Keyword) 壊死性筋膜炎 / Vibrio vulnificus / アルコール性肝障害
18.	Nobuyuki Sei, Yuko Matsuda, Akiyuki Senoo, Misa Iwasa, Kazuko Nishinaka, Setsuko Mori, Chikako Uenishi, Hiroshi Niki, Michiko Yamashita and Hiroshi Okitsu : A Case of False High Value of D-dimer Assumed to be a Nonspecific Reaction to Patient IgA, Tokushima Red Cross Hospital Medical Journal, Vol.18, No.1, 56-60, 2013. (Keyword) D ダイマー / IgA / 非特異反応 / 偽高値
19.	Yutaro Yamashita, Hiroaki Nagae, Mio Machida, Chihiro Takemori, Yoshio Urano, Michiko Yamashita and Yoshiyuki Fujii : A Case of Apocrine Adenocarcinoma, Tokushima Red Cross Hospital Medical Journal, Vol.18, No.1, 40-42, 2013. (Keyword) アポクリン腺癌 / 腋窩 / 皮膚悪性腫瘍
20.	Chiaki Kashino, Michiko Yamashita, Yoshiyuki Fujii, Hiroshi Okitsu, Yuri Masuda, Shunsuke Kuramoto, Daisuke Matsumoto, Yutaka Matsuoka, Atsushi Tomibayashi, Yoko Hamada, Yasuhiro Yuasa, Taeko Kawanaka, Hisashi Ishikura, Suguru Kimura and Akihiro Sakata : An Autopsy Case of Large Cell Appendiceal Neuroendocrine Carcinoma, Tokushima Red Cross Hospital Medical Journal, Vol.18, No.1, 30-35, 2013.
21.	Masahiro Osumi, Takashi Matsueda, Tatsuo Motoki, Atsushi Kurushima, Takashi Otani, Yoshiaki Fukumura, Yoshiyuki Fujii and Michiko Yamashita : An operative case of constrictive pericarditis with a pericardial cyst, Tokushima Red Cross Hospital Medical Journal, Vol.17, No.1, 128-131, 2012. (Keyword) 収縮性心膜炎 / 心膜嚢腫 / 心膜剥皮術
22.	Kenichiro Kita, Hiroshi Okitsu, Yasuhiro Yuasa, Takako Furukawa, Koichi Sato, Michiko Yamashita and Natsu Okitsu : 深達度sm でリンパ節転移を認めた直腸悪性黒色腫の1例, Tokushima Red Cross Hospital Medical Journal, Vol.17, No.1, 123-127, 2012. (Keyword) 直腸悪性黒色 / 深達度sm / 腹腔鏡下腹会陰式直腸切断術 / リンパ節転移
23.	Chihiro Taniguchi, Mio Machida, Yoshihiro Matsudate, Yoshio Urano, Shinichiro Kinouchi, Yasuo Gotoda, Hiroshi Okitsu, Michiko Yamashita and Yoshiyuki Fujii : Two cases of Ofuji papuloerythroderma associated with malignant tumor, Tokushima Red Cross Hospital Medical Journal, Vol.17, No.1, 90-93, 2012. (Keyword) 丘疹‐紅皮症 / 尿管癌 / 直腸癌 / 悪性腫瘍
24.	Atsuo Takeichi, Hidetaka Iwasaki, Hironori Akizuki, Michiko Yamashita and Yoshiyuki Fujii : Rapidly growing sublingual schwannoma : A case report, Tokushima Red Cross Hospital Medical Journal, Vol.17, No.1, 75-79, 2012. (Keyword) 舌腫瘍 / 神経鞘腫 / 縫合補強材 / 吸収性ポリグリコール酸フェルト / ネオベール
25.	Michiko Yamashita, Emi Murasawa, Jun Hayami, Atsushi Kurushima, Suguru Kimura and Yoshiyuki Fujii : A case of leiomyosarcoma arisen from the right thrombotic phlebitis, Tokushima Red Cross Hospital Medical Journal, Vol.17, No.1, 64-69, 2012. (Keyword) 平滑筋肉腫 / 静脈血栓症 / 静脈エコー / 骨軟部腫瘍
26.	Tsutomu Watanabe, Takeshi Ogose, Takako Taniguchi, Rieko Kondo, Koichi Shichijo, Masatami Matsushita, Akiyoshi Takahashi, Tadanori Nakatsu, Hirofumi Oka, Hajimu Miyake, Kyosuke Osaki, Michiko Yamashita, Tetsuya Goto and Midori Harada : Cerebral Yolk Sac Tumor in a 14-year-old Boy Undergoing Primary High-dose Chemotherapy with Autologous Peripheral Stem Cell Rescue, Tokushima Red Cross Hospital Medical Journal, Vol.17, No.1, 33-38, 2012. (Keyword) 脳胚細胞性腫瘍 / 卵黄嚢がん / 大量化学療法 / 自家末梢血幹細胞移植 / プラチナ製剤
27.	久保田真理, Hiroshi Okitsu, Daisuke Matsumoto, 古川尊子, 木原歩美, 松岡裕, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, Kazuo Yoshioka, Michiko Yamashita and 藤井義幸 : A Very Rare Case of Gastric Mesenchymal Tumor Treated by Pyloric Ring-preserving Laparoscopic Distal Gastrectomy, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 106-110, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762951894784 (CiNii: 1050845762951894784)
28.	Akihiro Hirao, 宮井優, 近藤絵里, 金崎淑子, 新谷保実, 宮恵子, 武市充生, Hidetaka Iwasaki, Hironori Akizuki, 木内慎一郎, 上間健造, Michiko Yamashita, 藤井義幸 and 藤野修 : A Case of IgG4-related Disease that Developed 10Years after Onset of Type2 Diabetes Mellitus, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 82-87, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762951888256 (CiNii: 1050845762951888256)
29.	岡西大介, Hiroshi Okitsu, Daisuke Matsumoto, 古川尊子, 松岡裕, 木原歩美, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, Michiko Yamashita and 藤井義幸 : A case of a low-differentiated adenocarcinoma in the transverse colon involving a neuroendocrine component, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 35-40, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762951880704 (CiNii: 1050845762951880704)
30.	辻真一郎, Hiroshi Okitsu, Daisuke Matsumoto, 古川尊子, 木原歩美, 松岡裕, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, 藤井義幸 and Michiko Yamashita : Two Cases of alpha-Fetoprotein-Producing Gastric Cancer Responding Well to Preoperative Chemotherapy, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 99-105, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287975182720 (CiNii: 1050564287975182720)
31.	Yasushi Fukuta, 加藤道久, 藏本俊輔, 山本香, 中井香, 當別當庸子, Naoji Mita, 郷律子, Michiko Yamashita, 藤井義幸 and 神山有史 : Near-drowning of a 34-Year-Old Woman Apparently Due to Cardiogenic Cardiac Arrest : A Case Report, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 88-92, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812998468736 (CiNii: 1050282812998468736)
32.	辻岡卓也, Hiroshi Okitsu, Daisuke Matsumoto, 古川尊子, 松岡裕, 木原歩美, 浜田陽子, Yasuhiro Yuasa, 石倉久嗣, 木村秀, 阪田章聖, Michiko Yamashita, 藤井義幸 and Kazuo Yoshioka : A Case of Metachronous Triple Cancers, Developing Descending Colon Cancer and alpha-Fetoprotein-Producing Gastric Cancer after Surgery for Lung Cancer That was Treated with Laparoscopic Surgery, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 93-98, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001338021759104 (CiNii: 1050001338021759104)
33.	Satoshi Tsutsumi, Suguru Kimura, Daisuke Matsumoto, Takako Furukawa, Yutaka Matsuoka, Ayumi Kihara, Yoko Hamada, Yasuhiro Yuasa, Hisashi Ishikura, Hiroshi Okitsu, Akihiro Sakata, Michiko Yamashita and Yoshiyuki Fujii : A Case of Lipoid Pneumonia That was Difficult to Diagnose, Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 124-127, 2011. (Keyword) リポイド肺炎 / 泡沫状マクロファージ / 胸腔鏡下肺生検
34.	Takushi Naroda, Toshinori Kasai, Kenzo Uema, Michiko Yamashita and Yoshiyuki Fujii : Giant testicular cancer : A case report, Tokushima Red Cross Hospital Medical Journal, Vol.15, No.1, 95-99, 2010. (Keyword) 巨大精巣癌 / 胚細胞腫瘍 / セミノーマ
35.	Yayoi Sasa, Keiji Ozaki, Naoko Ishibashi, Tomoko Hara, Tetsuya Goto, Yoshiyuki Fujii and Michiko Yamashita : Disseminated Trichosporonosis in Patients with Hematological Malignancies : Analysis of Two Autopsy Cases, Tokushima Red Cross Hospital Medical Journal, Vol.15, No.1, 65-69, 2010. (Keyword) 播種性トリコスポロン症 / ミカファンギン / hematological malignancy / ブレークスルー感染
36.	Misa Iwasa, Mako Minato, Tomomi Morikawa, Kuniko Kato, Kazuko Hamai, Michiko Yamashita, Akiyo Ono, Kazuyo Nakanishi, Akira Hirose, Mayumi Sugimoto, Takashi Ogose, Tsutomu Watanabe and Tetsuya Yoshida : Two cases of Dyphyllobothrium nihonkaiense infection, Tokushima Red Cross Hospital Medical Journal, Vol.15, No.1, 60-64, 2010. (Keyword) 虫卵検査 / 日本海裂頭条虫 / 病理組織検査
37.	Takako Umemoto, Rieko Kondo, Koichi Shichijo, Mayumi Sugimoto, Takashi Ogose, Tsutomu Watanabe, Tadanori Nakatsu, Tetsuya Yoshida, Hirofumi Oka, Hajimu Miyake, Ryozo Shirono, Michiko Yamashita and Yoshiyuki Fujii : Anaplastic Astrocytoma Appearing 7 Years After Cranial Radiotherapy for Acute Lymphocytic Leukemia, Tokushima Red Cross Hospital Medical Journal, Vol.15, No.1, 45-49, 2010. (Keyword) anaplastic astrocytoma / ALL / 二次がん / 放射線照射 / temozolomide
38.	Kanako Nakauchi, Michiko Nonogi, Eiji Yamamoto, Sunao Shimada, Yasuo Gotoda, Tomonori Yoshida, Koichi Sato, Junichi Nagata, Seiichi Nakano, Michiko Yamashita, Yoshiyuki Fujii and Koichi Kataoka : A Case of Autoimmune Pancreatitis Occurring with Mikulicz's Disease, Tokushima Red Cross Hospital Medical Journal, Vol.15, No.1, 55-59, 2010. (Keyword) 自己免疫性膵炎 / IgG4関連疾患 / ミクリッツ病
39.	Hiroaki Nagae, Yuichi Senzaki, Yoshiyuki Fujii and Michiko Yamashita : Experience with Lower Lip Reconstruction Using Advancement Flaps from the Cutaneous and Mucosal Sides, Tokushima Red Cross Hospital Medical Journal, Vol.14, No.1, 122-128, 2009. (Keyword) 下口唇再建 / 前進皮弁 / V-Y advancement flap / 有棘細胞癌
40.	Michiko Yamashita, Kyoko Takami, Kazuko Hamai, Kazuyo Nakanishi, Yoshiyuki Fujii, Shirou Bekku and Hiroyasu Ino : A Case of Chylous ascites Seemingly Attributable to Collapse of Lymphangioma, Tokushima Red Cross Hospital Medical Journal, Vol.14, No.1, 101-104, 2009. (Keyword) ovary / リンパ管腫 / 乳び腹水 / 細胞診
41.	Yoshio Urano, Rie Matsuda, Seiko Saito, Michiko Yamashita, Ryozo Shirono, Kimihiko Shimizu and Katsuhito Masuda : An Elderly Case of Scrofuloderma, Tokushima Red Cross Hospital Medical Journal, Vol.14, No.1, 66-69, 2009. (Keyword) 皮膚結核 / リンパ節結核 / 抗結核剤
42.	Takushi Naroda, Toshinori Kasai, Kenzo Uema, Takuya Minato, Akihiro Sakata, Michiko Yamashita and Yoshiyuki Fujii : A Case of Xanthogranulomatous Pyelonephritis Complicated by Colonic Perforation Five Days after Nephrectomy, Tokushima Red Cross Hospital Medical Journal, Vol.14, No.1, 56-61, 2009. (Keyword) 黄色肉芽腫性腎盂腎炎 / 腎摘 / 結腸穿孔
43.	Seiko Saito, Rie Matsuda, Yoshio Urano, Michiko Yamashita, Yoshiyuki Fujii and Kosaku Fukuhara : A Case of Cutaneous Nocardiosis, Tokushima Red Cross Hospital Medical Journal, Vol.13, No.1, 96-99, 2008. (Keyword) ノカルジア / 限局型 / 菌塊
44.	Mami Tanaka, Takuya Minato, Yoko Yamamura, Kazuhisa Katayama, Hisashi Ishikura, Toshihiro Ichimori, Masashi Ishikawa, Hiroshi Okitsu, Suguru Kimura, Akihiro Sakata, Michiko Yamashita and Yoshiyuki Fujii : A Case of Non-Hodgkin Lymphoma Presenting with Spontaneous Splenic Rupture, Tokushima Red Cross Hospital Medical Journal, Vol.13, No.1, 91-95, 2008. (Keyword) 脾破裂 / 悪性リンパ腫 / カテーテル塞栓術
45.	Noriaki Nagao, Michiko Yamashita, Eri Kondo, Tomoko Hara, Keiji Ozaki, Tetsuya Goto and Yoshiyuki FUjii : An Autopsied Case of Primary Central Nervous System Lymphomas Difficult to Distinguish from Glioblastoma, Tokushima Red Cross Hospital Medical Journal, Vol.13, No.1, 43-48, 2008. (Keyword) 脳原発悪性リンパ腫 / 膠芽腫 / びまん性大細胞型B 細胞リンパ腫
46.	Rie Matsuda, Yoshio Urano, Toshinori Kasai, Takushi Naroda, Kenzo Uema and Michiko Yamashita : A Case of Acute Generalized Exanthematous Pustulosis due to Ampicillin, Tokushima Red Cross Hospital Medical Journal, Vol.12, No.1, 45-47, 2007. (Keyword) acute generalized exanthematous pustulosis / アンピシリン/スルバクタム / 薬疹
47.	Tomoko Mizoki, Yoshikazu Hiasa, Miyazaki Shinichirou, Riyo Ogura, Miyajima Hitoshi, Yoshikazu Ohara, Kenichirou Yuba, Suzuki Naoki, Takehumi Takahashi, Shinobu Hosokawa, Hirokazu Kishi, Ryuji Ohtani, Tatsuo Motoki, Homare Yoshida, Takashi Ohtani, Yosiaki Fukumura, Michiko Yamashita and Yoshiyuki Fujii : A Sporadic Marfan Syndrome Diagnosed with Appearance of Heart Failure, Tokushima Red Cross Hospital Medical Journal, Vol.11, No.1, 85-90, 2006.
48.	Rie Matsuda, Kohichi Shichijyou, Yoshio Urano, Michiko Yamashita, Yoshiyuki Fujii and Masahiro Hirose : A Case of Premalignant Fibroepithelial Tumor, Tokushima Red Cross Hospital Medical Journal, Vol.11, No.1, 82-84, 2006. (Keyword) Premalignant Fibroepithelial Tumor / Pinkus / 腫瘍
49.	Takushi Naroda, Toshinori Kasai, Kenzo Uema, Shizuo Ikeyama, Hayato Tani, Norio Ohnishi, Ryozo Shirono, Michiko Yamashita and Yoshiyuki Fujii : Spontaneous Renal Pelvic Rupture Caused by Ureteral Cancer : A Case Report, Tokushima Red Cross Hospital Medical Journal, Vol.11, No.1, 100-105, 2006. (Keyword) 尿管癌 / 腎盂自然破裂 / 腎周囲出血
50.	Michiko Onishi, Mika Sakaki, 田中靖, Mitsuyoshi Hirokawa, Toshiaki Sano, Hiroki Ishibashi and Hiroo Takehara : 【内分泌病理学最近の進歩2002】副腎髄質と傍神経節から同時発生した小児褐色細胞腫, ホルモンと臨床, Vol.50, No.suppl., 200-205, 2002. (Keyword) 褐色細胞腫 / infant / X線CT / 副腎腫瘍 / 副腎髄質 / 傍神経節

Academic Letter:

1.	Yasutoshi Hida, Riho Nakano, Ryouga Yuasa, Kanna Maehama, Michiko Yamashita and Yoshio Urano : Erythema gyratum repens-like presentation of folliculotropic mycosis fungoides, Dermatology Online Journal, Vol.30, No.1, 22, 2024. (Keyword) erythema gyratum repens / folliculotropic / gamma chain / immunohistochemistry / mycosis fungoides / mycosis fungoides / polymerase chain reaction / T cell receptor
2.	Yasutoshi Hida, Riho Kageji, Hirofumi Bekku, Shunsuke Watanabe, Takuya Seike and Michiko Yamashita : Cutaneous T-cell lymphoma developing during nivolumab treatment for metastatic melanoma., Dermatology Online Journal, Vol.28, No.1, 2022. (Keyword) Humans / Lymphoma, T-Cell, Cutaneous / Melanoma / Neoplasms, Second Primary / Nivolumab / Skin Neoplasms (Tokushima University Institutional Repository) ● Metadata: 117441 (Link to Publication Site) ● Publication site (DOI): 10.5070/D328157071 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35499424 ● Search Scopus @ Elsevier (PMID): 35499424 ● Search Scopus @ Elsevier (DOI): 10.5070/D328157071 (Tokushima University Institutional Repository: 117441, DOI: 10.5070/D328157071, PubMed: 35499424)
3.	Takako Umemoto, Tsutomu Watanabe, Takeshi Ogose, Rieko Kondo, Tadanori Nakatsu, Akiyoshi Sakata, Michiko Yamashita and Tetsuya Gotho : Capillary leak syndrome: initial presentation in a patient with ALK+anaplastic large cell lymphoma associated with increased levels of serum cytokines., Leukemia & Lymphoma, Vol.52, No.6, 1139-1142, 2011. (Keyword) Adolescent / Anaplastic Lymphoma Kinase / Capillary Leak Syndrome / Cytokines / Granulocyte Colony-Stimulating Factor / Humans / Interferon-gamma / Interleukin-10 / Interleukin-6 / Lymphoma, Large-Cell, Anaplastic / Male / Receptor Protein-Tyrosine Kinases (Link to Publication Site) ● Publication site (DOI): 10.3109/10428194.2011.555893 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21463119 ● Search Scopus @ Elsevier (PMID): 21463119 ● Search Scopus @ Elsevier (DOI): 10.3109/10428194.2011.555893 (DOI: 10.3109/10428194.2011.555893, PubMed: 21463119)

Review, Commentary:

1.	Ryoji Ichishima, Michiko Yamashita and Takuji Gotoda : 消化管症候群(第3版) II ―その他の消化管疾患を含めて― IV 虫垂虫垂内分泌細胞癌, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.10, 228-231, Feb. 2020. (Keyword) 神経内分泌腫瘍 / 虫垂 / WHO分類
2.	Koichi Tsuneyama, Mayuko Shimizu, Takeshi Oya, Minoru Matsumoto, Tomoko Kobayashi, Hirohisa Ogawa, Kazuchika Nishitsuji and Michiko Yamashita : 肝臓病理所見のとり方とその解釈, 法医病理, Vol.25, No.1, 1-12, Jul. 2019.
3.	Michiko Yamashita : 臨床検査専門医がコッソリ教える⋯検査のTips! 第15回．ホルマリン固定すればすべて診断できる?, レジデントノート, Vol.20, 569-571, Jun. 2018.
4.	Michiko Yamashita : Pathological Examinations and Cancer Drugs, Shikoku Acta Medica, Vol.74, No.1, 7-12, Apr. 2018. (Summary) The aging rate of the Tokushima prefecture is reaching globally top levels, while its cancer morbidity rate also rises. Malignant tumors can develop from almost any site in the body. Each tumor has unique, individual growth speeds. In pathological examination, a histological name is determined as ditailedly as possible to clarify the growth pattern and the treatment strategy of the tumor. Malignant tumors can be lethal, but according to one study they hardly require prolonged nursing care.Histological diagnosis requires the following procedures : tumor identification, surgical dissection, fixing, dehydration, paraffin embedding, thin sectioning, staining, sealing, labeling and microscopic observation. Formalin-fixed paraffin embedded blocks, which help in the indication of molecular targeted drugs are generated through these processes. Since many targeted therapies block the EGFR-RAS-MAPK pathway, it is potentially one of the main mechanisms of cancer growth.Our most urgent needs include appropriate explanations about variety and "draggability" of the cancers and cultivating patients' "will to live." To maintain the dignity of cancer patients, we must assemble a fully developed cancer team that includes active pathologists in each local community. (Keyword) cancer / pathology / formalin-fixed paraffin embedded block / FFPE / molecular targeted drugs (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812443109248 (CiNii: 1050282812443109248)
5.	Michiko Yamashita, Yoshiyuki Fujii and Tetsuya Goto : なるほどわかった!日常診療のズバリ基本講座.∼研修医のためのCPC発表準備のポイント∼, レジデントノート, Vol.16, 721-728, Jun. 2014.

Proceeding of International Conference:

1.	Michiko Yamashita, Sarina Takeuchi, Mizuki Fujii, Hikaru Nishizoe, Mai Kanai, Yuko Matsuda, Nobuyuki Sei, Mitsuho Watanabe and Takahiko Kasai : Biochemical Markers Correlated to Gelationous Degeneration of Bone Marrow: An Autopsy Study, ANNALS OF LABORATORY MEDICINE, Vol.Supplement, No.42, S63, Seoul, Oct. 2022. (Keyword) Gelatinous degeneration / Serous atrophy / Bone marrow / cachexia / Protein-Energy Malnutrition

Proceeding of Domestic Conference:

1.	Ryo Fujimaru, Takaaki Tsunematsu, Koichi Tsuneyama and Michiko Yamashita : A case of IGF-2-producing hepatocellular carcinoma with severe hypoglycemia, Proceedings of the Japanese Society of Pathology, Mar. 2024.
2.	Nanami Yamashita, Yurie Takii, Natsumi Ohara, Yuko Narusawa, Akiyo Ono, Kazuyo Nakanishi, Shunsuke Watanabe, Takahiko Kasai, Yasuharu Kuwayama, Ryo Kataza, Yuriko Morikawa, Yoshimi Bando, Hisanori Uehara and Michiko Yamashita : A case of disseminated carcinoma of unknown primary origin, Tokushima Society of Clinical Cytology Academic Conference Abstracts, Mar. 2024.
3.	Natsumi Ohara, Yumiko Yamashita, Ayumi Masumi, Shingen Nakamura, Hirohisa Ogawa, Koichi Tsuneyama and Michiko Yamashita : A case of ascitic plasmacytosis needed to distinguish to the fluid overload large B cell lymphoma FO-LBCL, 第267回徳島医学会学術集会, Aug. 2023.
4.	Ryo Fujimaru, Michiko Yamashita, Takaaki Tsunematsu, Izumi Fukuda, Katsuyoshi Tamaki and Koichi Tsuneyama : IGF-2producing hepatocellular carcinoma with non-islet cell tumor hypoglycemia as the paraneoplastic syndrome, 第267回徳島医学会学術集会, Aug. 2023.
5.	Kengo Atsumi, Minoru Matsumoto, Michiko Yamashita, Filiz Midori Nishimura, Yasuharu Sato, Yoshimi Bando and Hisanori Uehara : Lymph node lesion, Japanese Society of Pathology Chugoku-Shikoku Block Academic Assembly, Jun. 2023. (Keyword) ATLL
6.	Shuji Kuwahara, Nobuyuki Sei, Toshio Shimizu, Mitsuho Watanabe, Mayu Nishikawa, Jun Hayami and Michiko Yamashita : A case of DLBCL detected MYD88L265P mutation using i-densy, Japanese Journal of Medical Technology, May 2023.
7.	Sakura Shigekiyo, Ayaka Yonezawa, Yuko Miyakami, Yuko Matsuda, Akiyo Ono, Kazuyo Nakanishi, Satoru Hatayama, Toshikazu Ueda, Syunsuke Watanabe, Takahiko Kasai, Syuji Kuwahara, Mitsuho Watanabe, Nobuyuki Sei, Yoshiyuki Fujii and Michiko Yamashita : A case of primary CNS lymphoma with detectable genetic mutation, Abstracts of the Annual Meeting of Tokushima Prefecture Society of Japanese Society of Clinical Cytology, Mar. 2023.
8.	KAJINO Akimi, Hitoshi Ikushima, Motoharu Sasaki, Tamaki Otani, Michiko Yamashita and Akihiro Haga : 放射線治療効果を早期に検出できるRadiomics特徴量の探索, 日本放射線腫瘍学会第35回学術大会, Nov. 2022.
9.	Michiko Yamashita, Asami Nishikori, Yasuharu Sato, Syunsuke Watanabe and Tadashi Yoshino : A case of two different cutaneous CD8+ T cell lymphomas developed after anti PD-1 therapy, Proceedings of the Japanese Society of Pathology, Vol.111, No.1, 86, Apr. 2022.
10.	渡邉俊介, 富田満, Michiko Yamashita, Takahiko Kasai and 藤井義幸 : 胃病変, 日本病理学会中国四国支部学術集会抄録集, 7, Feb. 2022.
11.	勢井伸幸, 志水俊夫, 渡辺光穂, 西川真由, 桑原周爾, 速水淳 and Michiko Yamashita : 小児における急性骨髄性白血病，非特異型(FAB分類M6)の1症例, Journal of the Japanese Society for Laboratory Hematology, Vol.22, S34, Sep. 2021.
12.	Michiko Yamashita : パネルディスカッション05 「臨床栄養における臨床検査値(体組成も含めて)の理解とRCPC(reversed clinico-pathological conference)の意義を考える」, Online Journal of JSPEN, Vol.1, No.supplement, Jul. 2021.
13.	Michiko Yamashita, Koichi Tsuneyama and Takeshi Oya : Bone marrow microenvironment on Bone marrow gelatinous degeneration, Proceedings of the Japanese Society of Pathology, Vol.110, No.1, 355, Apr. 2021.
14.	Kyoka Muguruma, Kazuya Kondo, Shiho Soejima, Birgun Tegsee, Michiko Yamashita, 岸渕麗奈, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku : 胸腺上皮性腫瘍におけるMT1A遺伝子のDNAメチル化とmRNA発現, 第40回日本胸腺研究会, Feb. 2021.
15.	渡邉俊介, 宮上侑子, Michiko Yamashita and 藤井義幸 : 軟部腫瘍, 第 133 回日本病理学会中国四国支部学術集会(スライドカンファレンス), Nov. 2020.
16.	渡辺力, 高橋昭良, 七條光市, 岡田朝美, 松本苑美, 武知敦美, 高見容子, 藤野修司, 谷口多嘉子, 中津忠則 and Michiko Yamashita : 全身型若年性特発性関節炎の診断時における骨髄検査の意義, The Journal of the Japan Pediatric Society, Vol.124, No.11, 1664, Nov. 2020.
17.	赤川洋子, 宇山直人, 武知克弥, 木下光博, 大西範生, 尾崎享祐, 谷勇人, 大塚秀樹, 石橋直子, 別宮浩文, 原朋子, 尾崎敬治, 後藤哲也 and Michiko Yamashita : 子宮原発びまん性大細胞型B細胞性リンパ腫の1例, Japanese Journal of Radiology, Vol.38, No.Suppl, 71, Feb. 2020.
18.	湯浅康弘, 福田美月, 牧秀則, 藤本啓介, 竹内大平, 常城宇生, 松尾祐太, 森理, 江藤祥平, 藤原聡史, 富林敦司, 石倉久嗣, Michiko Yamashita and 藤井義幸 : 胃に穿通し瘻孔形成した横行結腸癌の一例, The Journal of Japanese Gastroenterological Association, Vol.4, No.Suppl, 321, Jan. 2020.
19.	Takeshi Oya, Minoru Matsumoto, Noriko Kagawa, Michiko Yamashita, Hirohisa Ogawa and Koichi Tsuneyama : 小腸腫瘍の1例, 日本病理学会中国四国支部学術集会第130回スライドカンファレンス, Oct. 2019.
20.	Miwa Kubo, Shunsuke Watanabe, Michiko Yamashita, Takeshi Oya and Koichi Tsuneyama : 子宮頸部病変, 日本病理学会中国四国支部学術集会第128回スライドカンファレンス, Feb. 2019.
21.	Michiko Yamashita, Shingo Wakatsuki, 遠藤早希子, 佐竹宣法, 堀口英久, 小川博久 and Koichi Tsuneyama : 「病理夏の学校in徳島」における，検査値解析を用いた全学年参加CPC, Proceedings of the Japanese Society of Pathology, Vol.106, No.1, 327, Mar. 2017.
22.	Mio Machida, 谷口千尋, 杉野博崇, 長江浩朗, Michiko Yamashita, Tadamasa Yamamoto and 浦野芳夫 : 乳児に生じた隆起性皮膚繊維肉腫の1例, 第111回日本皮膚科学会総会, Jun. 2012.
23.	Seiko Kagawa, Hidehisa Horiguchi, Michiko Yamashita, 藤井義幸 and Naomi Sakashita : 心不全病態における糖質コルチコイド受容体発現の意義:剖検心を用いた人体病理学的研究, 第101回日本病理学会, Apr. 2012.
24.	Hidetaka Iwasaki, 武市充生, Michiko Yamashita, 藤井義幸 and Hironori Akizuki : 頸部リンパ節に発生した胚中心進展性異形成の2症例, 第73回耳鼻咽喉科臨床学会, Jun. 2011.
25.	湊拓也, 沖津宏, 田中麻美, 山村陽子, 片山和久, 木村秀, 坂田章聖, Michiko Yamashita, 藤井義幸, 丹黒章, Kouji Itou, 伊崎俊介 and 高野正志 : TS-1の術前2週投与により著効がえられた進行胃癌の2症例, 第80回日本胃癌学会総会, Feb. 2008.
26.	湊拓也, 沖津宏, 田中麻美, 山村陽子, 片山和久, 木村秀, 坂田章聖, Michiko Yamashita, 藤井義幸, Akira Tangoku, Kouji Itou, 伊崎俊介 and 高野正志 : TS-1の術前2週投与によりほぼCRがえられた進行胃癌の1症例, 第82回中国四国外科学会総会, Sep. 2007.
27.	Ken-ichi Aihara, Masashi Akaike, Hiroyuki Azuma, Toshio Matsumoto, Michiko Yamashita, Yoshimura Kimihiro and Imagawa Jun-ichi : Elevated blood pressure with a cardiovascular remodeling in mice lacking vitamin D receptor, 第66回日本循環器学会総会・学術集会, Apr. 2002.

Et cetera, Workshop:

1.	Sakura Shigekiyo, Ayaka Yonezawa, Shoichiro Takao, Yuko Narusawa and Michiko Yamashita : A study of quantitative analysis of bone marrow adipocytes using the Bz-X800 Analyzer, 徳島県臨床衛生検査技師会誌, 19, Dec. 2023.
2.	Ayaka Yonezawa, Sakura Shigekiyo, Yuko Narusawa and Michiko Yamashita : Examination of gelatinous transformation in extramedullary fat, 徳島県臨床衛生検査技師会誌, 18, Dec. 2023.
3.	Mizuki Fujii, Hikaru Nishizoe, Sarina Takeuchi and Michiko Yamashita : Gelatinous transformation of the bone marrow with myelofibrosis and CAR cells, THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 25, Dec. 2022.
4.	Hikaru Nishizoe, Mizuki Fujii, Shingen Nakamura, Shoichiro Takao and Michiko Yamashita : Muscle and lipid mass of blood disease., THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 24, Dec. 2022.
5.	Michiko Yamashita : Precision Medicine - From Community Hospital Perspective, 徳島大学大学院医歯薬研究部シンポジウム, Dec. 2021.
6.	Kohta Hata, Ryoga Yuasa, Sarina Takeuchi, Michiko Yamashita, Takeshi Oya, Koichi Tsuneyama and Mayuko Shimizu : 骨髄膠様変性時，臨床検査値と造血幹細胞ニッチはどう変化しているか, THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 28, Dec. 2021.
7.	Ryoga Yuasa, Kohta Hata, Sarina Takeuchi, Michiko Yamashita, Ryohei Sumitani, Hisanori Uehara, Yoshimi Bando and Koichi Tsuneyama : 同種骨髄移植後の造血微小環境についての病理学的研究, THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 27, Dec. 2021.
8.	Sarina Takeuchi, Yurie Kobayashi, Michiko Yamashita, Takeshi Oya and Koichi Tsuneyama : Immunohistochemical study of hematopoietic niche-forming cells in gelatinous degeneration of bone maro, THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 18, Dec. 2020.
9.	Yurie Kobayashi, Sarina Takeuchi, Michiko Yamashita, Koichi Tsuneyama and Mayuko Shimizu : Statistical study of laboratory values correlated with gelatinous degeneration of bone marrow, THE TOKUSHIMA JOURNAL OF MEDICAL TECHNOLOGY, 19, Dec. 2020.

Report:

1.	石川正志, 松岡裕, 垣本歩美, 田中麻美, 湊拓也, 山村陽子, 石倉久嗣, 一森敏弘, 木村秀, 阪田章聖, Michiko Yamashita, 藤井義幸, 池山鎮夫, 谷勇人, 大西範夫 and 城野良三 : 胆嚢十二指腸瘻を形成した胆石症例の検討, The Japanese journal of clinical and experimental medicine, Vol.85, No.12, 1765-1768, Fukuoka, Dec. 2008.
2.	Seisuke Okamura, 木村哲夫, 矢野弘美, 井本佳孝, 梶雅子, 青木利佳, 佐藤康紀, Hiroshi Miyamoto, Naoki Muguruma, Susumu Ito, Michiko Yamashita, Toshiaki Sano, 池本哲也, Masahiko Fujii and Hidenori Miyake : 膵管内発育を主とし特異な形態を呈した膵腺房細胞癌の1例, 消化器画像, Vol.9, No.1, 41-46, Jan. 2007.
3.	米田亜樹子, Toshiaki Sano, 久元恵美子, Michiko Yamashita and 山田正三 : Folliculostellate cell(FSC)の極めて豊富な下垂体腺腫, Folia endocrinologica Japonica, Vol.81, No.2, 585-586, Sep. 2005.
4.	Mitsuyoshi Hirokawa, Michiko Yamashita, Toshiaki Sano and 加島健司 : Ki-67 labeling indexが高値を示す部分が多発性にみられた非浸潤性多形腺腫内癌の1例, 日本唾液腺学会抄録集, 36-37, Dec. 2004.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Novel Cancer Treatment Strategies Based on Radiomics Imaging Analysis (Project/Area Number: 23K07158 )
Search by Researcher Number (40793071)

Associate Professor : Yamashita, Michiko

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)