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Tokushima UniversityGraduate School of Biomedical Sciences薬学域先端薬学教育研究プロジェクト
Tokushima UniversityGraduate School of Biomedical Sciences薬学域Pharmaceutical SciencePharmaceutical SciencesDepartment of Bioorganic Synthetic Chemistry
Tokushima UniversityFaculty of Pharmaceutical SciencesSchool of Pharmaceutical Technosciences創薬学講座Bioorganic Synthetic Chemistry
Tokushima UniversityGraduate School of Pharmaceutical SciencesPharmaceutical Sciences
Tokushima UniversityResearch ClustersResearch Clusters2202002 独自の解析技術と疾患科学の融合によるリボソーム創薬の創生
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Research

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Field of Study

Life sciences [Clinical pharmacy]
Life sciences [Pharmaceuticals - chemistry and drug development]

Subject of Study

Book / Paper

Book:

1. Masaya Denda :
第9章 チーム医療,
Oct. 2020.

Academic Paper (Judged Full Paper):

1. Rin Miyajima, Kosuke Tanegashima, Naoto Naruse, Masaya Denda, Takahiro Hara and Akira Otaka :
Identification of Low-Density Lipoprotein Receptor-Related Protein 1 as a CXCL14 Receptor Using Chemically Synthesized Tetrafunctional Probes,
ACS Chemical Biology, 2024.
(DOI: 10.1021/acschembio.3c00717)
2. Takashi Tsuji, Honoka Tsunematsu, Masaki Imanishi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka :
Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole,
Bioorganic & Medicinal Chemistry Letters, 129484, 2023.
(DOI: 10.1016/j.bmcl.2023.129484,   PubMed: 37716415)
3. Mami Neishi, Hirofumi Hamano, Takahiro Niimura, Masaya Denda, Kenta Yagi, Koji Miyata, Tsung-Jen Lin, Tsukasa Higashionna, Mitsuhiro Goda, Yoshito Zamami, Keisuke Ishizawa and Hideki Nawa :
Structural characterization of the optical isomers esomeprazole and omeprazole using the JADER and FAERS databases,
Toxicology and Applied Pharmacology, Vol.475, 116632, 2023.
(DOI: 10.1016/j.taap.2023.116632,   PubMed: 37482254,   Elsevier: Scopus)
4. OHKAWACHI Kento, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki and Akira Otaka :
Residue-selective CH sulfenylation enabled by acid-activated S-acetamidomethyl cysteine sulfoxide with application to one-pot stapling and lipidation sequence,
Chemistry - A European Journal, 2023.
(Tokushima University Institutional Repository: 118080,   DOI: 10.1002/chem.202300799)
5. Daishiroh Kobayashi, KURAOKA Eisuke, Junya Hayashi, Takuma Yasuda, Yutaka Kohmura, Masaya Denda, Norio Harada, Nobuya Inagaki and Akira Otaka :
S-Protected cysteine sulfoxide-enabled tryptophan-selective modification with application to peptide lipidation,
ACS Medicinal Chemistry Letters, Vol.13, No.7, 1125-1130, 2022.
(Tokushima University Institutional Repository: 117175,   DOI: 10.1021/acsmedchemlett.2c00161)
6. Masato Miyake, Mitsuaki Sobajima, Kiyoe Kurahashi, Akira Shigenaga, Masaya Denda, Akira Otaka, Tomohide Saio, Naoki Sakane, Hidetaka Kosako and Seiichi Oyadomari :
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells.,
Cell Chemical Biology, Vol.29, No.6, 996-1009.e9, 2022.
(Tokushima University Institutional Repository: 116761,   DOI: 10.1016/j.chembiol.2022.01.002,   PubMed: 35143772)
7. Daiki Sato, Masaya Denda, Honoka Tsunematsu, Naonobu Tanaka, Isamu Konishi, Chiaki Komiya, Akira Shigenaga and Akira Otaka :
Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation,
Chemical Communications, Vol.58, No.17, 2918-2921, 2022.
(Tokushima University Institutional Repository: 116717,   DOI: 10.1039/D1CC07248J,   PubMed: 35138311)
8. Kazuto Nakae, Sho Masui, Atsushi Yonezawa, Motomu Hashimoto, Ryu Watanabe, Koichi Murata, Kosaku Murakami, Masao Tanaka, Hiromu Ito, Kotoko Yokoyama, Noriko Iwamoto, Takashi Shimada, Miyuki Nakamura, Masaya Denda, Kotaro Itohara, Shunsaku Nakagawa, Yasuaki Ikemi, Satoshi Imai, Takayuki Nakagawa, Makoto Hayakari and Kazuo Matsubara :
Potential Application of Measuring Serum Infliximab Levels in Rheumatoid Arthritis Management: A Retrospective Study based on KURAMA Cohort Data,
PLoS ONE, Vol.16, No.10, e0258601, 2021.
(DOI: 10.1371/journal.pone.0258601,   PubMed: 34644354)
9. Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka :
Copper (II)-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides,
Chemical Communications, Vol.57, 10763-10766, 2021.
(Tokushima University Institutional Repository: 116325,   DOI: 10.1039/D1CC04856B,   PubMed: 34585682)
10. Daishiroh Kobayashi, Yutaka Kohmura, Toshihiko Sugiki, Eisuke Kuraoka, Masaya Denda, Toshimichi Fujiwara and Akira Otaka :
Peptide Cyclization Mediated by Metal-Free S-Arylation: S-Protected Cysteine Sulfoxide as an Umpolung of Cysteine Nucleophile,
Chemistry - A European Journal, Vol.27, No.56, 14092-14099, 2021.
(Tokushima University Institutional Repository: 116324,   DOI: 10.1002/chem.202102420)
11. Masahiro Ueda, Chiaki Komiya, Sayuki Arii, Kohshi Kusumoto, Masaya Denda, Keiichiro Okuhira, Akira Shigenaga and Akira Otaka :
Sequence-independent traceless method for preparation of peptide/protein thioesters using CPaseY-mediated hydrazinolysis,
Chemical & Pharmaceutical Bulletin, Vol.68, No.12, 1226-1232, 2020.
(DOI: 10.1248/cpb.c20-00674,   PubMed: 33028801)
12. Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka :
Deprotection of S-Acetamidomethyl Cysteine with Copper (II) and 1,2-Aminothiols under Aerobic Conditions,
Organic & Biomolecular Chemistry, Vol.18, 8638-8645, 2020.
(Tokushima University Institutional Repository: 115115,   DOI: 10.1039/D0OB01475C)
13. Kento Ohkawachi, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka :
Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis,
Organic Letters, Vol.22, No.14, 5289-5293, 2020.
(Tokushima University Institutional Repository: 114733,   DOI: 10.1021/acs.orglett.0c01383,   PubMed: 32396369)
14. Yunpeng Zhang, Atsushi Yonezawa, Shunsaku Nakagawa, Satoshi Imai, Masaya Denda, Tomohiro Omura, Takayuki Nakagawa and Kazuo Matsubara :
Cisplatin, rather than oxaliplatin, increases paracellular permeability of LLC-PK1 cells via activating protein kinase C.,
Drug Metabolism and Pharmacokinetics, Vol.35, No.1, 111-116, 2019.
(DOI: 10.1016/j.dmpk.2019.09.001,   PubMed: 31964622,   Elsevier: Scopus)
15. Atushi Yonezawa, Yuki Otani, Toshiyuki Kitano, Mayuko Mori, Sho Masui, Yui Isomoto, Masahiro Tsuda, Satoshi Imai, Yasuaki Ikemi, Masaya Denda, Yuki Sato, Shunsaku Nakagawa, Tomohiro Omura, Takayuki Nakagawa, Ikuko Yano, Makoto Hayakari, Akifumi Takaori-Kondo and Kazuo Matsubara :
Concentration and Glycoform of Rituximab in Plasma of Patients with B Cell Non-Hodgkin's Lymphoma.,
Pharmaceutical Research, Vol.36, No.6, 82, 2019.
(DOI: 10.1007/s11095-019-2624-5,   PubMed: 30989405,   CiNii: 1050845763182203520,   Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1. Kohta Hidaka, JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka :
Advanced Insulin Synthesis by One-pot/stepwise Disulfide Bond Formation Enabled by Acid-activated S-Protected Cysteine Sulfoxide in the Presence of Chloride Anion,
ChemRxiv, 2024.
(DOI: 10.26434/chemrxiv-2024-jg5z3)
2. Daishiroh Kobayashi, Masaya Denda, JUNYA Hayashi, Kohta Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, OHKAWACHI Kento, Kiyomi Nigorikawa, Tetsuro Yoshimaru, Naozumi Ishimaru, Nomura Wataru, Toyomasa Katagiri, Hidetaka Kosako and Akira Otaka :
Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization,
ChemRxiv, 2024.
(DOI: 10.26434/chemrxiv-2024-tkv7w-v2)
3. Kaito Anzaki, OHKAWACHI Kento, Daishiroh Kobayashi, Kyan Ryuji, Masaya Denda, Akira Shigenaga and Akira Otaka :
Residue-Specific Modification Reaction Using S-Acetamidomethyl Cysteine Sulfoxide, Cys(Acm)(O),
Peptide Science 2021, 55-56, 2022.
4. Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka :
Development of copper and iron-mediated Cys-Trp-linking reaction,
Peptide Science 2021, 9-12, 2022.
5. OHKAWACHI Kento, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka :
A New Thiol Additive for One-pot Sequential Peptide Ligation-Desulfurization Chemistry,
Peptide Science 2020, 25-26, 2021.
6. Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka :
Deprotection of S-Acetamidomethyl Cysteine Mediated by Copper Salts,
Peptide Science 2020, 49-52, 2021.

Review, Commentary:

1. Masaya Denda and Akira Otaka :
Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences,
Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 316-323, May 2022.
(DOI: 10.1248/cpb.c21-01019)

Proceeding of International Conference:

1. Daishiro Kobayashi, Masaya Denda and Akira Otaka :
S-Protected cysteine sulfoxide-enabled peptide and protein customization methodology,
Biologics 2024, London, Mar. 2024.
2. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO SYNTHESIS OF INSULIN AND ITS LIPIDATED ANALOGUE,
13th International Peptide Symposium 15th Australian Peptide Conference, Brisbane, Oct. 2023.
3. JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka :
DEVELOPMENT OF OXIDANT FREE METHODOLOGY FOR PREPARING N-GLYOXYLYL PEPTIDE AND ITS APPRICATIONS,
13th International Peptide Symposium 15th Australian Peptide Conference, Brisbane, Oct. 2023.
4. Daishiro Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka :
Protein tryptophan modification enabled by using S-protected cysteine sulfoxide under mild acid conditions,
13th International Peptide Symposium 15th Australian Peptide Conference, Brisbane, Oct. 2023.
5. Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Mina Hojo, Sayaka Tani, Masaya Denda, Hitoshi Mizuguchi and Akira Otaka :
Development of synthetic method for synthesizing di-Tyr-containing bi-aryl peptides enabled by oxidation of sulfenyl Tyr,
AIMECS 2023, Seoul, Jun. 2023.
6. Chiho Shinozaki, Yutaka Kohmura, Tetsuro Yoshimaru, Tsuyoshi Tahara, Masaya Denda, Hidefumi Mukai, Kohta Mohri, Yi Long Chen, Toyomasa Katagiri and Akira Otaka :
Study on a lipidated anti-cancer peptide allowing long-lasting duration in mice model,
AIMECS 2023, Seoul, Jun. 2023.
7. Akira Otaka, OHKAWACHI Kento, Kaito Anzaki and Masaya Denda :
Tyr- or Trp-selective CH sulfenylation enabled by acid- activated S-acetamidomethyl cysteine sulfoxide,
19th Akabori Conference German-Japanese Symposium on Peptide Science, 大津市, May 2023.

Proceeding of Domestic Conference:

1. JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka :
主鎖アミド保護基を活用したLossen転位反応による 合成後期ペプチドα位ヘテロ化法の開発,
日本薬学会第144年会, Mar. 2024.
2. Chiho Shinozaki, Yutaka Kohmura, Tetsuro Yoshimaru, Masaya Denda, Toyomasa Katagiri and Akira Otaka :
脂肪酸修飾型乳がん増殖抑制ペプチドの開発,
第40回メディシナルケミストリーシンポジウム, Nov. 2023.
3. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
脂肪鎖修飾型インスリン誘導体合成を指向したS-保護システインスルホキシドを利用したワンポットジスルフィド形成/脂肪酸修飾法の開発,
第40回メディシナルケミストリーシンポジウム, Nov. 2023.
4. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
IMPROVEMENT OF INSULIN SYNTHESIS BY COMBINATION OF O-ACYL ISOPEPTIDE METHOD AND ONE-POT/STEPWISE DISULFIDE BOND FORMATION USING S-PROTECTED CYSTEINE SULFOXIDE,
第60回ペプチド討論会, Nov. 2023.
5. Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Sayaka Tani, Mina Hojo, Masaya Denda, Hitoshi Mizuguchi and Akira Otaka :
DEVELOPMENT OF SYNTHETIC METHOD FOR DI-TYR CONTAINING PEPTIDES RELATED TO PARKINSONS DISEASE ENABLED BY OXIDATION SULFENYL TYR,
第60回ペプチド討論会, Nov. 2023.
6. Daiki Sato, Chiho Shinozaki, Masaya Denda and Akira Otaka :
DEVELOPMENT OF INTERMOLECULAR ACYLATION PROTOCOL OF THREONINE BY A LATE-STAGE SEQUENTIAL ACYL TRANSFER DESULFURIZATION,
第60回ペプチド討論会, Nov. 2023.
7. Daishiro Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka :
TRYPTOPHAN-SELECTIVE PEPTIDE MODIFICATION USING S-ACETAMIDEMETHYL PROTECTED CYSTEINE SULFOXIDE UNDER MILD ACIDIC CONDITION AND ITS APPLICATION TO PEPTIDE HETERODIMERIZATION,
第60回ペプチド討論会, Nov. 2023.
8. JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka :
PREPARATION METHODOLOGY OF N-GLYOXYLYL PEPTIDE UTILIZING LOSSEN REARRANGEMENT,
第60回ペプチド討論会, Nov. 2023.
9. JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka :
Lossen転位を利用したペプチドN末端アルデヒド化法の開発と応用,
第49回反応と合成の進歩シンポジウム, Nov. 2023.
10. Daishiroh Kobayashi, JUNYA Hayashi, Kohta Hidaka, Yutaka Kohmura, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
Interrupted Pummerer反応によるTrp選択的修飾を利用したOne-potペプチドヘテロ二量化法の開発,
第49回反応と合成の進歩シンポジウム, Nov. 2023.
11. OHTA Rika, SATOH Daiki, Masaya Denda and Akira Otaka :
刺激応答性機能変換ペプチドの新規合成法の開発,
第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
12. EGUCHI Aki, OHKAWACHI Kento, Mika Ohhira, Masaya Denda and Akira Otaka :
脂質ナノディスクを利用した難溶解性膜タンパク質化学合成法の開発,
第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
13. INAZUKI Hayato, Takashi Tsuji, Daishiro Kobayashi, JUNYA Hayashi, Masaya Denda and Akira Otaka :
Cysteinyl Prolyl Esterシステムを利用した新規医薬品放出制御システムの開発研究,
第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
14. NAGATA Tsunaki, Tomoki Nonaka, Daishiro Kobayashi, Masaya Denda and Akira Otaka :
Cys(MBzl)(O)を利用したTrp位置選択的脂肪鎖修飾法の開発と修飾GIP調製への応用,
第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
15. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
保護システインスルホキシドを用いたワンポット連続ジスルフィド形成 によるインスリンの合成研究,
創薬懇話会2023 湯河原, Jun. 2023.
16. Daiki Satoh, Chiho Shinozaki, Masaya Denda and Akira Otaka :
ユビキチン化の機能解明を志向した新規スレオニン側鎖アシル化法の開発,
日本ケミカルバイオロジー学会 第17回年会, May 2023.
17. Masaya Denda, Tomoki Nonaka, Daishiro Kobayashi, JUNYA Hayashi, Yasuda Takuma, Yutaka Kohmura, Harada Norio, Inagaki Nobuya and Akira Otaka :
S-保護システインスルホキシドを利用したトリプトファン選択的修飾法の開発,
日本ケミカルバイオロジー学会 第17回年会, May 2023.
18. OHKAWACHI Kento, Kaito Anzaki, Daishiro Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka :
S-保護システインスルホキシドを利用した残基選択的C-Hスルフェニル化反応の開発,
日本薬学会第143年会, Mar. 2023.
19. Daiki Satoh, Chiho Shinozaki, Masaya Denda and Akira Otaka :
連続アシル転移を利用した分子内および分子間スレオニン側鎖アシル化法の開発,
日本薬学会第143年会, Mar. 2023.
20. Kohki Fukuhara, Tsubasa Inokuma, MASUI Kana, Masaya Denda, Akira Otaka and Ken-ichi Yamada :
N-2-Nitrophenylsulfenylイミノペプチドへのジアステレオ選択的インドリル化反応の開発,
日本薬学会第143年会, Mar. 2023.
21. JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka :
アシルイミニウムカチオンを経由したペプチド主鎖修飾反応の開発,
第48回反応と合成の進歩シンポジウム, Nov. 2022.
22. Tomoki Nonaka, Daishiro Kobayashi, KURAOKA Eisuke, JUNYA Hayashi, Yasuda Takuma, Yutaka Kohmura, Masaya Denda, Harada Norio, Inagaki Nobuya and Akira Otaka :
S-保護システインスルホキシドを利用したトリプトファン選択的脂肪鎖修飾法の開発と応用,
第39回メディシナルケミストリーシンポジウム, Nov. 2022.
23. Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Mina Hohjoh, Hitoshi Mizuguchi, Masaya Denda and Akira Otaka :
スルフェニル化Tyrを利用したTyr-Tyrビアリール構造含有ペプチド合成法の開発,
第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
24. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
S-保護システインスルホキシドを利用したトリプトファン選択的修飾反応の開発とペプチドヘテロ二量化法への応用展開,
第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
25. Tsubasa Inokuma, MASUI Kana, Masaya Denda, Akira Otaka and Ken-ichi Yamada :
Diastereoselective indolylation of N-2-nitrophenylsulfenyl iminopeptide for the synthesis of α-indolylglycine-containing peptide,
第59回ペプチド討論会, Oct. 2022.
26. Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka :
DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO INSULIN SYNTHESIS,
第59回ペプチド討論会, Oct. 2022.
27. JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka :
DEVELOPMENT OF INTRAMOLECULAR THIOETHERIFICATION ON PEPTIDE BACKBONE FOR CHEMICAL SYNTHESIS OF SACTIPEPTIDE,
第59回ペプチド討論会, Oct. 2022.
28. JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka :
ペプチド主鎖修飾反応の開発とチオエーテル含有環状ペプチド合成への展開,
第54回若手ペプチド夏の勉強会, Aug. 2022.
29. Daishiroh Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka :
保護システインスルホキシドを利用したペプチド・タンパク質Trp残基選択的修飾法の開発研究,
第54回若手ペプチド夏の勉強会, Aug. 2022.
30. JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka :
Lossen転位を起点とした合成後期ペプチド主鎖ヘテロ化反応の開発,
創薬懇話会2022 in 名古屋, Jul. 2022.
31. Daishiroh Kobayashi, KURAOKA Eisuke, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka :
S-保護システインスルホキシドを利用したトリプトファン選択的修飾反応の開発研究,
日本薬学会第142年会, Mar. 2022.
32. Yutaka Kohmura, Daishiroh Kobayashi, Masaya Denda and Akira Otaka :
MBzl保護システインスルホキシドの芳香族化合物に対する反応性評価とペプチド架橋法への応用展開,
日本薬学会第142年会, Mar. 2022.
33. SATOH Daiki, Honoka Tsunematsu, Isamu Konishi, UEDA Tomoko, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka :
側鎖無保護ペプチドへの適用可能な合成後期ラクトン化法の開発,
日本薬学会第142年会, Mar. 2022.
34. Akito Ohnishi, Akiko Higashiyama, Shunya Yanagawa, 清良 尚史, W John Regan, Kento Ohkawachi, Masaya Denda, Keijo Fukushima, Akira Otaka and Hiromichi Fujino :
プロスタノイドEP4受容体の1アミノ酸変異によるシグナル伝達プロファイル変化,
第95回日本薬理学会年会,福岡, Mar. 2022.
35. Kaito Anzaki, OHKAWACHI Kento, Daishiroh Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka :
RESIDUE-SPECIFIC MODIFICATION REACTION USING S-ACETAMIDOMETHYL CYSTEINE SULFOXIDE, Cys(Acm)(O),
第58回ペプチド討論会, Oct. 2021.
36. Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka :
Development of copper and iron-mediated Cys-Trp-linking reaction,
第58回ペプチド討論会, Oct. 2021.
37. Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka :
銅添加を鍵としたシステイン-トリプトファン間架橋反応の開発研究,
第53回若手ペプチド夏の勉強会, Aug. 2021.
38. Tomoki Nonaka, Kento Ohkawachi, Masaya Denda and Akira Otaka :
Sulfanylmethyl DMAPを利用した環状ペプチド合成に関する研究,
第53回若手ペプチド夏の勉強会, Aug. 2021.
39. Kaito Anzaki, Kento Ohkawachi, Daishiroh Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka :
Acm 保護 Cys スルホキシドを利用した化学選択的 S-Aryl 化反応開発研究,
第53回若手ペプチド夏の勉強会, Aug. 2021.
40. Kaito Anzaki, Kento Ohkawachi, Daishiroh Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka :
保護Cysスルホキシドを利用したS–Aryl化環状ペプチド合成研究,
創薬懇話会2021 in 京都, Jun. 2021.
41. Yutaka Kohmura, Daishiroh Kobayashi, 杉木 俊彦, Tetsuro Yoshimaru, Eisuke Kuraoka, Masaya Denda, 藤原 敏道, Toyomasa Katagiri and Akira Otaka :
Cys-Trp 架橋型乳がん抑制ペプチド(ERAP)の合成及び活性評価,
創薬懇話会2021 in 京都, Jun. 2021.
42. Masaya Denda, Chiaki Komiya, Masahiro Ueda, Jun Tsukimoto, Kouji Itou, Akira Shigenaga and Akira Otaka :
既存モダリティの高度化を指向したペプチド・タンパク質新規修飾法の開発,
日本薬剤学会第36年会, May 2021.
43. SATOH Daiki, Honoka Tsunematsu, UEDA Tomoko, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka :
側鎖無保護ペプチドを用いた環状デプシペプチド簡便合成法の開発,
日本薬学会第141年会, Mar. 2021.
44. Daishiroh Kobayashi, Yutaka Kohmura, KURAOKA Eisuke, Masaya Denda and Akira Otaka :
S-保護システインスルホキシドを利用したCys-Trpチオエーテル結合形成反応の開発,
日本薬学会第141年会, Mar. 2021.
45. Daiki Satoh, Honoka Tsunematsu, Tomoko Ueda, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka :
Development of a protection-free protocol for the synthesis of lactone peptides,
第57回ペプチド討論会, Nov. 2020.
46. Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka :
Deprotection of S-acetamidomethyl cysteine mediated by copper salts,
第57回ペプチド討論会, Nov. 2020.
47. Kento Ohkawachi, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka :
A new thiol additive for one-pot sequential peptide ligation-desulfurization chemistry,
第57回ペプチド討論会, Nov. 2020.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Development of a method for modifying peptides using cation-generating sulfoxides (Project/Area Number: 23H02609 )
  • ペプチド環化反応をトリガーとした抗がん剤新規放出システム搭載型ADCの創出研究 (Project/Area Number: 22K15253 )
  • TDM解析を基盤とした、リウマチ治療における生物学的製剤適正使用法の確立研究 (Project/Area Number: 19K16445 )
  • Search by Researcher Number (00813891)