Tokushima University / Educator and Researcher Directory --- Ito, Asuka

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Book:

1.	Naoko Tanaka, Hiroshi Kinoshita, Mostofa Jamal, Asuka Ito, Tadayoshi Yamashita, Mitsuru Kumihashi and Kiyoshi Ameno : Diagnostic application of CO-oximeter for hypothermia in forensic practice, Nova Science Publishers, NY, USA, 2021. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85109467404 (Elsevier: Scopus)

Academic Paper (Judged Full Paper):

1.	Hideyuki Nushida, Asuka Ito, Hiromitsu Kurata, Itsuo Tokunaga, Hitomi Umemoto, Hirofumi Iseki and Akiyoshi Nishimura : A case of thoracic organs migrating into the left upper arm subcutaneously due to a runover, Forensic Imaging, Vol.35, 200567, 2023. (Keyword) Thoracic organ / Migration / Postmortem computed tomography / Forensic autopsy (Tokushima University Institutional Repository) ● Metadata: 119597 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.fri.2023.200567 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85175306408 (Tokushima University Institutional Repository: 119597, DOI: 10.1016/j.fri.2023.200567, Elsevier: Scopus)
2.	Hideyuki Nushida, Asuka Ito, Hiromitsu Kurata, Hitomi Umemoto, Itsuo Tokunaga, Hirofumi Iseki and Akiyoshi Nishimura : A case of fatal multi-organ inflammation following COVID-19 vaccination., Legal Medicine, Vol.63, 102244, 2023. (Summary) A 14-year-old Japanese girl died unexpectedly 2days after receiving the third dose of the BNT1262b2 mRNA COVID-19 vaccine. Autopsy findings showed congestive edema of the lungs, T-cell lymphocytic and macrophage infiltration in the lungs, pericardium, and myocardium of the left atria and left ventricle, liver, kidneys, stomach, duodenum, bladder, and diaphragm. Since there was no preceding infection, allergy, or drug toxicity exposure, the patient was diagnosed with post-vaccination pneumonia, myopericarditis, hepatitis, nephritis, gastroenteritis, cystitis, and myositis. Although neither type of inflammation is fatal by itself, arrhythmia is reported to be the most common cause of death in patients with atrial myopericarditis. In the present case, arrhythmia of atrial origin was assumed as the cause of cardiac failure and death. In sudden post-vaccination deaths, aggressive autopsy systemic search and histological examination involving extensive sectioning of the heart, including the atrium, are indispensable. (Keyword) Adolescent / Female / Humans / Atrial Fibrillation / COVID-19 / COVID-19 Vaccines / Death, Sudden / Inflammation / Myocarditis / Vaccination (Tokushima University Institutional Repository) ● Metadata: 118536 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.legalmed.2023.102244 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36990036 ● Summary page in Scopus @ Elsevier: 2-s2.0-85151022406 (Tokushima University Institutional Repository: 118536, DOI: 10.1016/j.legalmed.2023.102244, PubMed: 36990036, Elsevier: Scopus)
3.	Asuka Ito, Hideyuki Nushida, Hiromitsu Kurata, Hitomi Umemoto, Hirofumi Iseki, Itsuo Tokunaga and Akiyoshi Nishimura : A case of complete decapitation in suicidal hanging: the mechanism and condition of decapitation, The Journal of Medical Investigation : JMI, Vol.70, No.1,2, 290-293, 2023. (Summary) Complete decapitation due to suicide by hanging is rare. We report the case of a decapitated man who was found in the sea near an estuary. A polyethylene rope was tied to the handrail of the bridge across a strait near the site of the body. The rope was 12 mm in diameter and 19 m in length from the handrail. It ended with a slip knot noose, and skin and mustache-like hair fragments were attached to it. The decapitated head was not found. The deceased weighed 82 kg and was 152 cm long without the head. The autopsy revealed coarse abrasions and intramuscular hemorrhage around the severed edge. The third cervical spine was not fractured. We reviewed the literature and suggested the conditions of body weight, fall height, rope diameter, and number of rolls in cases of decapitation by hanging. We calculated the hanging decapitation index (HDI) as the fall height (m) multiplied by the body weight (kg), divided by the rope diameter (mm), divided by the number of rolls ; and discussed the differences between complete and incomplete decapitation cases. J. Med. Invest. 70 : 290-293, February, 2023. (Keyword) decapitation / hanging / suicide / case report / forensic medicine (Tokushima University Institutional Repository) ● Metadata: 118288 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.290 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164737 ● Search Scopus @ Elsevier (PMID): 37164737 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.290 (Tokushima University Institutional Repository: 118288, DOI: 10.2152/jmi.70.290, PubMed: 37164737)
4.	Hirofumi Iseki, 倉田浩充, Hideyuki Nushida, Asuka Ito and Akiyoshi Nishimura : Motion Analysis of Falls in Infants Using Kinect, Acta Criminologiae et Medicinae Legalis Japonica, Vol.88, No.2, 30-37, 2022. (Keyword) child fall / accidental trauma / forensic diagnosis / depth camera (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520855676744438784 (CiNii: 1520855676744438784)
5.	Mostofa Jamal, Asuka Ito, Takanori Miki, Shingo Suzuki, Ken-Ichi Ohta and Hiroshi Kinoshita : Ethanol concentration induces production of 3,4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway., Neuroscience Letters, Vol.782, 2022. (Summary) First, we aimed to investigate ex vivo the effects of ethanol (EtOH) on levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and their metabolites in the frontal cortex, hippocampus, and striatum of Aldh2-knockout (Aldh2-KO) and wild-type (WT) mice. Animals were treated intraperitoneally with saline (control) or EtOH (1.0, 2.0, or 3.0g/kg). Brain samples were collected 60 and 120min after EtOH injection, and monoamines and their metabolites were measured by HPLC-ECD. We found in both WT and Aldh2-KO mice that 3.0g/kg EtOH increased the levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and decreased the level of 3-methoxytyramine (3-MT). A 2.0g/kg dose of EtOH also increased HVA, but there was not a consistent effect within the brain regions of Aldh2-KO and WT mice. There were inconsistent findings of genotype differences in the levels of DA, 5-HT, and their metabolites in the brain regions tested. None of the EtOH doses altered NE, DA, 5-HT, or 5-hydroxyindoleacetic acid contents in any of the brain regions studied. Second, we tested whether EtOH-induced increases in DOPAC and HVA are mediated by increased monoamine oxidase (MAO) or catechol-O-methyltransferase (COMT) activity. To test this, we used the MAO blocker clorgyline (2.0 and 4.0mg/kg) and the COMT blocker tolcapone (15 and 30mg/kg) alone or in combination with EtOH (3.0g/kg). Clorgyline alone increased 3-MT and decreased DOPAC and HVA levels, whereas tolcapone alone increased DOPAC and decreased 3-MT and HVA levels. Surprisingly, the combination of EtOH with clorgyline (4.0mg/kg) or tolcapone (30mg/kg) further decreased 3-MT and increased DOPAC and HVA levels, an effect that reversed the inhibitor-induced decreases in HVA. These results suggest that a high concentration of EtOH can accelerate DA metabolism, as evidenced by the increase in DOPAC and HVA, and this effect is likely a consequence of increased degradation of DA by MAO. (Keyword) 3,4-Dihydroxyphenylacetic Acid / Aldehyde Dehydrogenase, Mitochondrial / Animals / Brain / Catechol O-Methyltransferase / Clorgyline / Ethanol / Homovanillic Acid / Mice / Monoamine Oxidase / Norepinephrine / Serotonin / Tolcapone (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2022.136689 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35598694 ● Search Scopus @ Elsevier (PMID): 35598694 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2022.136689 (DOI: 10.1016/j.neulet.2022.136689, PubMed: 35598694)
6.	Hiroshi Kinoshita, Naoko Tanaka, Mitsuru Kumihashi, Mostofa Jamal, Asuka Ito, Tadayoshi Yamashita and Kiyoshi Ameno : Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450, Vojnosanitetski Pregled, Vol.78, No.5, 563-566, 2021. (Link to Publication Site) ● Publication site (DOI): 10.2298/VSP170508090K (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2298/VSP170508090K (DOI: 10.2298/VSP170508090K)
7.	Mostofa Jamal, Asuka Ito, Naoko Tanaka, Kiyoshi Ameno and Hiroshi Kinoshita : High ethanol and acetaldehyde decrease extracellular glutamate in the frontal cortex of freely moving mice., NeuroReport, 2020. (Link to Publication Site) ● Publication site (DOI): 10.1097/WNR.0000000000001493 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32576773 ● Search Scopus @ Elsevier (PMID): 32576773 ● Search Scopus @ Elsevier (DOI): 10.1097/WNR.0000000000001493 (DOI: 10.1097/WNR.0000000000001493, PubMed: 32576773)
8.	Mostofa Jamal, Asuka Ito, Naoko Tanaka, Takanori Miki, Kiyoshi Ameno and Hiroshi Kinoshita : High Ethanol and Acetaldehyde Inhibit Glutamatergic Transmission in the Hippocampus of Aldh2-Knockout and C57BL/6N Mice: an In Vivo and Ex Vivo Analysis., Neurotoxicity Research, Vol.37, No.3, 702-713, 2020. (Link to Publication Site) ● Publication site (DOI): 10.1007/s12640-020-00180-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32062779 ● Search Scopus @ Elsevier (PMID): 32062779 ● Search Scopus @ Elsevier (DOI): 10.1007/s12640-020-00180-6 (DOI: 10.1007/s12640-020-00180-6, PubMed: 32062779)
9.	Razib Md Hossain, Mostofa Jamal, Yu Tanoue, Daiki Ojima, Hiroo Takahashi, Takashi Kubota, M Tuba Ansary, Asuka Ito, Naoko Tanaka, Hiroshi Kinoshita, Yasushi Kishimoto and Tohru Yamamoto : MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis., Neuroscience Letters, Vol.716, 2019. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2019.134677 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31812551 ● Search Scopus @ Elsevier (PMID): 31812551 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2019.134677 (DOI: 10.1016/j.neulet.2019.134677, PubMed: 31812551)
10.	Asuka Ito, Mostofa Jamal, Kiyoshi Ameno, Naoko Tanaka, Ayaka Takakura, Toshihiro Kawamoto, Kyoko Kitagawa, Keiichi Nakayama, Akiko Matsumoto, Takanori Miki and Hiroshi Kinoshita : Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice., Neuroscience Letters, Vol.685, 50-54, 2018. (Summary) Acetaldehyde (AcH) and salsolinol play important roles in the central effects of ethanol. This study aimed to investigate the effect of administration of AcH on dopamine (DA), DA-derived salsolinol and serotonin (5-HT) levels in the dorsal striatum of Aldh2-knockout (Aldh2-KO) and C57BL/6N (WT) mice. Animals were treated with AcH (50, 100 and 200mg/kg) intraperitoneally and dialysate levels of DA, 5-HT and salsolinol were determined using in vivo microdialysis coupled with HPLC-ECD. Salsolinol was first detected at 20min after AcH administration, and reached its peak concentration (WT mice: 0.29±0.22pg/μl; Aldh2-KO mice: 0.63±0.17pg/μl) at 25min in the 200mg/kg AcH group, before decreasing rapidly and reaching zero at approximately 55-80min. Treatment with 100 and 200mg/kg AcH increased levels of salsolinol in both WT and Aldh2-KO mice, with 200mg/kg AcH inducing a higher level of salsolinol in Aldh2-KO mice than in WT mice. Treatment with 50mg/kg AcH produced a small increase in salsolinol levels in Aldh2-KO mice, whereas no elevation of salsolinol was detected in WT mice. The increase in salsolinol formation was found to occur a dose-dependent manner in both genotypes. Administration of AcH and the subsequent changes in salsolinol concentrations did not change DA or 5-HT levels in either genotype. Our study suggests that AcH dose-dependently increases the formation of salsolinol in the dorsal striatum of mice, which provides further support for the role of AcH in salsolinol formation in the animal brain. (Keyword) Acetaldehyde / Aldehyde Dehydrogenase, Mitochondrial / Animals / Brain / Dopamine / Ethanol / Isoquinolines / Mice, Inbred C57BL / Mice, Knockout / Serotonin (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2018.07.032 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30036570 ● Search Scopus @ Elsevier (PMID): 30036570 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2018.07.032 (DOI: 10.1016/j.neulet.2018.07.032, PubMed: 30036570)

Academic Letter:

1.	Hideyuki Nushida, Asuka Ito, Hiromitsu Kurata and Akiyoshi Nishimura : Answer to the letter to the editor by J. Finsterer concerning "A case of fatal multi-organ inflammation following COVID-19 vaccination" by H. Nushida et al. (https://doi.org/10.1016/j.legalmed.2023.102244.), Legal Medicine, Vol.64, 2023. (Keyword) Humans / COVID-19 / COVID-19 Vaccines / Vaccination (Tokushima University Institutional Repository) ● Metadata: 118535 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.legalmed.2023.102282 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37364408 ● Search Scopus @ Elsevier (PMID): 37364408 ● Search Scopus @ Elsevier (DOI): 10.1016/j.legalmed.2023.102282 (Tokushima University Institutional Repository: 118535, DOI: 10.1016/j.legalmed.2023.102282, PubMed: 37364408)

Proceeding of Domestic Conference:

1.	Asuka Ito, Hideyuki Nushida, 倉田浩充, HITOMI Umemoto, Itsuo Tokunaga, ISEKI Hirofumi, Nanaka Yoshida and Akiyoshi Nishimura : 床下収納に陥入した体位性窒息の1例, 第40回日本法医学会学術中四国地方集会, Oct. 2023.
2.	ISEKI Hirofumi, 倉田浩充, Hideyuki Nushida, Asuka Ito, HITOMI Umemoto, Nanaka Yoshida, Itsuo Tokunaga and Akiyoshi Nishimura : 幼児の転倒動作解析における頭部打撲例, 第40回日本法医学会学術中四国地方集会, Oct. 2023.
3.	ISEKI Hirofumi, 倉田浩充, Hideyuki Nushida, Asuka Ito, HITOMI Umemoto and Akiyoshi Nishimura : 小児の日常動作中の転倒における頭部の運動分析, 第14回日本子ども虐待医学会学術集会, Jul. 2023.
4.	Hideyuki Nushida, Asuka Ito, 倉田浩光, ISEKI Hirofumi, HITOMI Umemoto, Koichi Tomita, Yoshihiro Tsuruo, Itsuo Tokunaga and Akiyoshi Nishimura : 死後CTにおける凍結による脳画像の変化, 第107次日本法医学会学術全国集会, Jun. 2023.
5.	Akiyoshi Nishimura, Asuka Ito, 倉田浩充, HITOMI Umemoto, Itsuo Tokunaga, ISEKI Hirofumi and Hideyuki Nushida : COVID-19ワクチン接種2日後に死亡した1剖検例, 第107次日本法医学会学術全国集会, Jun. 2023.
6.	Hitomi Umemoto, Asuka Ito, 倉田浩充, Hideyuki Nushida, Itsuo Tokunaga, ISEKI Hirofumi and Akiyoshi Nishimura : インスリン過量投与による低血糖脳症の1例, 第39回日本法医学会学術中四国地方集会, Oct. 2022.
7.	Asuka Ito, Hideyuki Nushida, 倉田浩充, HITOMI Umemoto, Itsuo Tokunaga, ISEKI Hirofumi and Akiyoshi Nishimura : 轢過により胸部臓器が上腕皮下に迷入した1例, 第39回日本法医学会学術中四国地方集会, Oct. 2022.
8.	ISEKI Hirofumi, 倉田浩充, Hideyuki Nushida, Asuka Ito, Itsuo Tokunaga, Hitomi Umemoto and Akiyoshi Nishimura : 3次元ビデオによる小児の転倒の動作解析, 第265回徳島医学会学術集会, Jul. 2022.
9.	Asuka Ito, 倉田浩充, Hideyuki Nushida, Itsuo Tokunaga, HITOMI Umemoto, Hirofumi Iseki and Akiyoshi Nishimura : 交通事故受傷から約3日後に死亡した遅発性S状結腸穿孔の1剖検例, 第265回徳島医学会学術集会, Jul. 2022.
10.	Asuka Ito, 倉田浩充, Hideyuki Nushida, Itsuo Tokunaga, Hitomi Umemoto, Hirofumi Iseki and Akiyoshi Nishimura : 交通事故による遅発性S状結腸穿孔の1剖検例, 第106次日本法医学会学術全国集会, Jun. 2022.
11.	Hirofumi Iseki, 倉田浩充, Hideyuki Nushida, Asuka Ito, 徳永逸夫 and Akiyoshi Nishimura : 3次元ビデオによる小児の転倒の動作解析第1報, 第38回日本法医学会学術中四国地方集会, Oct. 2021.
12.	Asuka Ito, 倉田浩充, Hideyuki Nushida, 徳永逸夫, Hitomi Umemoto and Akiyoshi Nishimura : 縊頸による頸部断裂の1例, 第38回日本法医学会学術中四国地方集会, Oct. 2021.
13.	Hideyuki Nushida, Hitomi Umemoto, Asuka Ito, 倉田浩充, 徳永逸夫 and Akiyoshi Nishimura : 低温保存死体における死後CT画像の検討, 第105次日本法医学会学術全国集会, Sep. 2021.
14.	Asuka Ito, ジャーマルモストファ, 田中直子, 山下忠義, 木下博之 and Akiyoshi Nishimura : n-プロパノールとプロピオンアルデヒドの血中濃度 -Aldh2ノックアウトマウスでの検討-, 第105次日本法医学会学術全国集会, Sep. 2021.
15.	Asuka Ito, 田中直子, モストファジャーマル, 山下忠義, 飴野清, 木村正司 and 木下博之 : 介護用品による窒息の2症例, 日本法医学雑誌, Vol.74, No.1, 83, Aug. 2020.

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