徳島大学 / 教育研究者総覧 --- 山本雄貴

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

1.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yuishin Izumi and Yasushi Takagi : Efficacy of the Dual Stent Retriever Technique for Branching-Site Occlusions in Mechanical Thrombectomy, Journal of Neuroendovascular Therapy, 20, 1, 2026-0003, 2026. (要約) Mechanical thrombectomy (MT) is an established treatment for acute ischemic stroke due to large vessel occlusion. Although achieving first-pass effect (FPE) is strongly associated with clinical outcomes, branching-site occlusions remain technically challenging and are associated with lower FPE rates. The dual stent retriever (DSR) technique has been proposed to improve thrombus engagement in branching vessel anatomy. This study aimed to evaluate the efficacy and safety of the DSR technique in patients with branching-site occlusions. We retrospectively reviewed consecutive patients with angiographically confirmed branching-site occlusions who underwent MT between January 2020 and April 2025. Patients were classified according to the first-line thrombectomy strategy into a DSR group or a single SR (SSR) group. We compared the FPE rate, procedural complications, and prognosis between the groups. Furthermore, an adjusted analysis was performed using Firth's penalized logistic regression. Among 105 eligible patients, 20 were treated with the DSR technique. The rate of FPE was significantly higher in the DSR group than in the SSR group (90.0% vs. 27.1%, p <0.001), whereas procedure time and complications did not differ between groups. After adjustment for relevant confounders, the DSR technique remained independently associated with FPE (adjusted odds ratio [aOR] 38.92, 95% confidence interval [CI] 4.60-329.39, p <0.001) and favorable functional outcome (aOR 4.59, 95% CI 1.03-20.36, p = 0.045). The DSR technique showed an association with higher rates of first-pass reperfusion in branching-site occlusions without a clear increase in procedural risk, indicating that it may be a feasible option in selected cases, although confirmation in prospective studies is needed. (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.oa.2026-0003 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41978768 ● Search Scopus @ Elsevier (PMID): 41978768 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.oa.2026-0003 (DOI: 10.5797/jnet.oa.2026-0003, PubMed: 41978768)
2.	Yuki Yamamoto, Nobuaki Yamamoto, Ayato Kageyama, Izumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yasushi Takagi and Yuishin Izumi : The Railroad Technique: A Mechanical Thrombectomy Approach Using Serial Deployment of Two Stent Retrievers for Tandem ICA-M1 Embolic Occlusion, Journal of Neuroendovascular Therapy, 19, 1, 0125, 2025. (要約) Tandem occlusions in acute ischemic stroke are usually atherothrombotic; however, in rare cases, they may result from simultaneous emboli at both proximal and distal sites. Embolic tandem occlusions pose challenges for endovascular therapy because single-stent retrievers (SRs) or aspiration approaches often require multiple passes. This report describes a novel technique that uses serially aligned SRs for en bloc retrieval. A 90-year-old woman with atrial fibrillation presented with a National Institutes of Health Stroke Scale (NIHSS) score of 22. Imaging revealed an embolic tandem occlusion of the intracranial internal carotid artery (ICA) and the M1 segment of the middle cerebral artery (MCA), with a large penumbra and no ischemic core. A mechanical thrombectomy was performed. Using a 0.074-inch inner diameter distal access catheter, a microcatheter was guided into the M2 inferior trunk. An SR (4 × 40 mm) was deployed across the M2 trunk from the M1 thrombus, followed by the deployment of another SR (6 × 37 mm) across the ICA thrombus. This "Railroad Technique," in which 2 SRs are deployed in a straight, serial alignment, enabled simultaneous capture and en bloc retrieval of both thrombi in a single pass, resulting in recanalization of the ICA and M1. A 2nd pass with an SR and aspiration catheter resulted in modified thrombolysis in cerebral infarction (mTICI) 2b reperfusion. The patient recovered rapidly. The Railroad Technique may be a feasible option for embolic tandem occlusions with large thrombus volumes and anatomically distant lesions. (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.tn.2025-0125 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41496899 ● Search Scopus @ Elsevier (PMID): 41496899 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.tn.2025-0125 (DOI: 10.5797/jnet.tn.2025-0125, PubMed: 41496899)
3.	兼松康久, 亘雄也, 鹿草宏, 山口泉, 宮本健志, 高麗雅章, 島田健司, 田村哲也, 黒田一駿, 佐藤健太, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 徳島県におけるICTを利用した, 脳卒中患者搬送プロトコール, 四国医学雑誌, 81, 1, 2, 41-44, 2025年. (要約) <p> 脳卒中の急性期においては，発症後直ちに適切な診療を開始する必要がある．このため，救急現場から医療機関への迅速かつ的確な搬送体制の整備が喫緊の課題である．近年，血栓回収療法の登場により，急性期脳梗塞患者に対する治療戦略は大きく変化した．従来のrt-PA静注療法では，主幹動脈などの大血管閉塞に対する再開通率が低く，予後改善効果も限定的であった．一方，血栓回収療法は大血管閉塞に対して高い有効性を示す．徳島県では，進化を続ける脳卒中治療に対応すべく，脳卒中患者搬送プロトコールの整備を進めている．その一環として，われわれは徳島県消防局と連携し，2022年1月より病院前脳卒中スケールを導入し，血栓回収療法が必要と考えられる患者を迅速に受け入れる体制を構築した．さらに，救急隊との情報共有には「JoinTriage」というICTアプリケーションを活用している．JoinTriageは，救急隊が病院前脳卒中スケールによる評価を簡便に実施し，その情報をリアルタイムで脳卒中センターへ送信することにより，迅速な血栓回収療法の開始を可能とするものである．本稿では，これらの取り組みから得られた成果と，新たな徳島県脳卒中搬送プロトコール策定に至る経緯について報告する．</p> (キーワード) prehospital transport system / mechanical thrombectomy / ICT-based platform (出版サイトへのリンク) ● Publication site (DOI): 10.57444/shikokuactamedica.81.1.2_41 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390304792177920768 ● Search Scopus @ Elsevier (DOI): 10.57444/shikokuactamedica.81.1.2_41 (DOI: 10.57444/shikokuactamedica.81.1.2_41, CiNii: 1390304792177920768)
4.	Kenji Shimada, Izumi Yamaguchi, Yuki Yamamoto, Takeshi Miyamoto, Shu Sogabe, Masaaki Korai, Nobuaki Yamamoto, Mami Hanaoka, Yasuhisa Kanematsu, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi : Differences in Clinical Features between Osseous and Nonosseous Arteriovenous Fistulas in the Cavernous Sinus, Neurosurgery Practice, 6, 2, 2025. (キーワード) Arteriovenous fistula / Cavernous sinus / Extraosseous / Intraosseous (出版サイトへのリンク) ● Publication site (DOI): 10.1227/neuprac.0000000000000131 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-105001794174 (DOI: 10.1227/neuprac.0000000000000131, Elsevier: Scopus)
5.	Kaori Nii, Hirokazu Ogino, Hiroki Bando, Yuki Yamamoto, Koji Fujita, Hiroto Yoneda, Nobuhito Naito, Atsushi Mitsuhashi, Yutaka Morita, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Seidai Satou, Masaki Hanibuchi, Yuishin Izumi and Yasuhiko Nishioka : Immune checkpoint inhibitor-associated paraneoplastic cerebellar degeneration in a case of extensive-stage small-cell lung cancer with pre-existing anti-SOX1 antibody, The Journal of Medical Investigation : JMI, 72, 1.2, 172-176, 2025. (要約) Neurological immune-related adverse events can manifest as paraneoplastic neurological syndrome (PNS), especially in patients with small-cell lung cancer (SCLC). We herein report a 73-year-old man with SCLC treated with an immune checkpoint inhibitor (ICI) combined with chemotherapy. Although the chemo-immunotherapy induced a favorable response to SCLC, he later developed acute cerebellar ataxia. He was diagnosed with paraneoplastic cerebellar degeneration associated with anti-Sry-like high mobility group box 1 (SOX1) autoantibody. The antibody was also identified in serum collected at the diagnosis of SCLC and before ICI administration, which retrospectively suggested that the patient was at risk of ICI-induced PNS. J. Med. Invest. 72 : 172-176, February, 2025. (キーワード) anti-SOX1 autoantibody / immune checkpoint inhibitors / paraneoplastic cerebellar degeneration / small-cell lung cancer (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.72.172 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40268441 ● Summary page in Scopus @ Elsevier: 2-s2.0-105003981938 (DOI: 10.2152/jmi.72.172, PubMed: 40268441, Elsevier: Scopus)
6.	Ryohei Nakao, Yuki Yamamoto, Ryosuke Miyamoto, K Tachibana, Masaki Kamada, Hiroyuki Morino and Yuishin Izumi : Adult-onset adenosine deaminase-2 deficiency presenting with recurrent juvenile cerebral infarction:A case report, The Journal of Medical Investigation : JMI, 72, 3, 4, 430-433, 2025.
7.	Ryohei Nakao, Yuki Yamamoto, Ryosuke Miyamoto, Konoka Tachibana, Masaki Kamada, Hiroyuki Morino and Yuishin Izumi : Adult-onset adenosine deaminase-2 deficiency presenting with recurrent juvenile cerebral infarction:A case report., The Journal of Medical Investigation : JMI, 72, 3.4, 430-433, 2025. (要約) Adenosine deaminase 2 (ADA2) deficiency is a rare autosomal recessive autoinflammatory disorder characterized by systemic vasculitis, recurrent stroke, and immunodeficiency. This results from the biallelic loss-of-function variants of ADA2, leading to enzymatic dysfunction and endothelial impairment. Although it is commonly diagnosed during childhood, adult-onset cases with milder phenotypes have also been reported.We report a case of adult-onset ADA2 deficiency that presented with recurrent juvenile stroke and systemic vasculitis.A 42-year-old female with recurrent juvenile stroke and systemic vasculitis symptoms was diagnosed with ADA2 deficiency by genetic testing. The patient had a known pathogenic variant, c.139G>C (p.Gly47Arg), in a homozygous state. Given the mild phenotype and stable condition, the patient continued long-term aspirin therapy without additional immunosuppressive treatment.This case highlights the importance of considering ADA2 deficiency in patients with unexplained stroke and recurrent vasculitis, particularly those with a history of parental consanguinity. Measurement of serum ADA activity may serve as a potential screening tool for ADA2 deficiency, especially in settings in which genetic testing is not readily available. J. Med. Invest. 72 : 430-433, August, 2025. (キーワード) Humans / Female / Adenosine Deaminase / Adult / Cerebral Infarction / Recurrence / Agammaglobulinemia / Severe Combined Immunodeficiency / Intercellular Signaling Peptides and Proteins (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.72.430 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41183948 ● Search Scopus @ Elsevier (PMID): 41183948 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.72.430 (DOI: 10.2152/jmi.72.430, PubMed: 41183948)
8.	Yasuhisa Kanematsu, Yuki Kanazawa, Kenji Shimada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Izumi Yamaguchi, Takeshi Oya, Nobuaki Yamamoto, Yuki Yamamoto, Miyoshi Mitsuharu, Masafumi Harada and Yasushi Takagi : Characterization of carotid plaques using chemical exchange saturation transfer imaging, Neuroradiology, 66, 9, 1617-1624, 2024. (要約) The preoperative assessment of carotid plaques is necessary to render revascularization safe and effective. The aim of this study is to evaluate the usefulness of chemical exchange saturation transfer (CEST)-MRI, particularly amide proton transfer (APT) imaging as a preoperative carotid plaque diagnostic tool. We recorded the APT signal intensity on concentration maps of 34 patients scheduled for carotid endarterectomy. Plaques were categorized into group A (APT signal intensity ≥ 1.90 E-04; n = 12) and group B (APT signal intensity < 1.90 E-04; n = 22). Excised plaques were subjected to histopathological assessment and, using the classification promulgated by the American Heart Association, they were classified as intraplaque hemorrhage-positive [type VI-positive (tVI)] and -negative [no intraplaque hemorrhage (tVI)]. Of the 34 patients, 22 (64.7%) harbored tVI- and 12 (35.3%) had tVI plaques. The median APT signals were significantly higher in tVI- than tIVI patients (2.43 E-04 (IQR = 0.98-4.00 E-04) vs 0.54 E-04 (IQR = 0.14-1.09 E-04), p < .001). Histopathologically, the number of patients with tVI plaques was significantly greater in group A (100%, n = 12) than group B (45%, n = 22) (p < .01). The number of symptomatic patients or asymptomatic patients with worsening stenosis was also significantly greater in group A than group B (75% vs 36%, p < .01). In unstable plaques with intraplaque hemorrhage and in patients with symptoms or progressive stenosis, the ATP signals were significantly elevated. CEST-MRI studies has the potential for the preoperative assessment of the plaques' characteristics. (キーワード) Humans / Male / Female / Aged / Carotid Stenosis / Magnetic Resonance Imaging / Middle Aged / Endarterectomy, Carotid / Plaque, Atherosclerotic / Sensitivity and Specificity / Image Interpretation, Computer-Assisted (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00234-024-03401-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38866959 ● Search Scopus @ Elsevier (PMID): 38866959 ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-024-03401-3 (DOI: 10.1007/s00234-024-03401-3, PubMed: 38866959)
9.	Yuki Yamamoto, Koji Fujita, Hiroki Yamazaki, Shotaro Haji, Yusuke Osaki and Yuishin Izumi : Constipation in patients with motor neuron disease: A retrospective longitudinal study, Heliyon, 10, 6, e27951, 2024. (キーワード) Amyotrophic lateral sclerosis / Constipation / Enteral nutrition / Motor neuron disease (徳島大学機関リポジトリ) ● Metadata: 2013493 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.heliyon.2024.e27951 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85188015432 (徳島大学機関リポジトリ: 2013493, DOI: 10.1016/j.heliyon.2024.e27951, Elsevier: Scopus)
10.	Mihoko Sasahara, Moriaki Yamanaka, Tomoki Matsushita, Takashi Abe, Maki Otomo, Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Yuishin Izumi, Yasushi Takagi, Mitsuharu Miyoshi and Masafumi Harada : Evaluation of the Ischemic Penumbra and Prognosis in acute Cerebral Infarction Using Cerebral Blood Flow and Delay Time Derived from Multi-delay pCASL Imaging, The Journal of Medical Investigation : JMI, 71, 3.4, 286-292, 2024. (要約) The purpose of this study was to evaluate the ischemic penumbra and prognosis in acute cerebral infarction using cerebral blood flow (CBF) and delay time (DT) derived from multi-delay pseudo-continuous arterial spin-labeling (pCASL) imaging and to estimate the possible use of such indices to predict prognosis. Our subjects comprised 25 patients who were diagnosed with cerebral infarction in our stroke center between September 2017 and December 2018 and underwent pCASL perfusion MRI. The time from onset to MRI was 0.6 to 20 h (mean, 6 h) and was less than 4.5 h in 16 patients. Twelve patients received conservative treatment, three were treated with tPA, and the remaining 10 patients underwent invasive treatment (e.g., thrombectomy). They were subdivided by recanalization:18 patients were non-recanalized and 7 were recanalized. We evaluated the mean cerebral blood flow (CBF) and mean arterial transit DT at the infarct core and penumbra and the infarct size at the initial and follow-up examinations and calculated the infarct enlargement ratio (ER) from the initial and final infarct sizes. We also assessed clinical prognosis by using the initial and final NIHSS scores. We investigated the relationship among the ASL, ER, and NIHSS parameters and determined predictors of infarct enlargement using logistic analysis. The degree of the CBF decrease was related to the size of the initial infarct lesion (CBF at core:r=-0.4060, p=0.044;CBF at penumbra:r=-0.4970, p=0.012) and initial NIHSS (r=-0.451, p=0.024;CBF at penumbra:r=-0.491, p=0.013). Because no parameters were correlated with the ER in all patients. Specifically in the non-recanalization group, the DT at the penumbra was positively correlated with the ER (r=-0.496, p=0.034). Moreover, by logistic regression analysis, the DT at the penumbra was the only independent predictor of infarct enlargement in all patients (p=0.047) and in non-recanalization patients (p=0.036). The only parameter predicting the ER was the mean DT at the penumbra, and the tendency was affected by recanalization status. DT obtained by multi-delay ASL may become a prognostic index of acute cerebral infarction. J. Med. Invest. 71 : 286-292, August, 2024. (キーワード) Cerebral Blood Flow / Cerebral Infarction / Delay Time / Ischemic Penumbra / pCASL (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.71.286 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39462566 ● Summary page in Scopus @ Elsevier: 2-s2.0-85207995342 (DOI: 10.2152/jmi.71.286, PubMed: 39462566, Elsevier: Scopus)
11.	Yuki Yamamoto, Nobuaki Yamamoto, Tomohiro Matsuda, Kazutaka Kuroda, Izumi Yamaguchi, Shu Sogabe, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : Stent retrieval for free-floating thrombus attached to carotid artery stenosis: A report of two cases., Surgical Neurology International, 14, 274, 2023. (要約) In cases of carotid artery stenosis with FFT, it is technically possible to retrieve a thrombus with a stent retriever. Although thrombus removal may help reduce the risk of ischemic complications in a series of urgent CAS procedures, there are concerns such as mechanical irritation to the carotid artery plaque, and its indications and alternative treatments should be carefully considered. (徳島大学機関リポジトリ) ● Metadata: 2012100 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_513_2023 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37680937 ● Search Scopus @ Elsevier (PMID): 37680937 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_513_2023 (徳島大学機関リポジトリ: 2012100, DOI: 10.25259/SNI_513_2023, PubMed: 37680937)
12.	Nobuaki Yamamoto, Kazutaka Kuroda, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, Ryoma Morigaki, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : Long-sheath Introducer-assisted Revascularization (L-SHARE) Technique for Treating Large-vessel Occlusion by a Giant Clot, Internal Medicine, 62, 6, 909-913, 2023. (要約) Revascularization for common carotid artery (CCA) occlusion might be difficult. We reported our strategy for revascularizing CCA occlusion by giant clots. A 94-year-old woman was transferred to our hospital because of right hemiparesis and aphasia. CCA occlusion and giant clots were detected on ultrasonography. We performed mechanical thrombectomy using a 9-Fr balloon-guiding catheter, stent retriever, and aspiration catheter through a 9-Fr long-sheath introducer [long-sheath introducer-assisted revascularization (L-SHARE) technique]. We successfully recanalized CCA occlusion using this method. The L-SHARE technique might be useful for recanalization of CCA occlusion. (キーワード) mechanical thrombectomy / long-sheath introducer / giant clot / cerebral large-vessel occlusion (徳島大学機関リポジトリ) ● Metadata: 2011533 (出版サイトへのリンク) ● Publication site (DOI): 10.2169/internalmedicine.0089-22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35945008 ● CiNii @ 国立情報学研究所 (CRID): 1390576900004177024 ● Search Scopus @ Elsevier (PMID): 35945008 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.0089-22 (徳島大学機関リポジトリ: 2011533, DOI: 10.2169/internalmedicine.0089-22, PubMed: 35945008, CiNii: 1390576900004177024)
13.	Manabu Ishihara, Yasuhisa Kanematsu, Nobuaki Yamamoto, Kenji Shimada, Takeshi Miyamoto, Izumi Yamaguchi, Shu Sogabe, Yuki Yamamoto, Jun Oto and Yasushi Takagi : Prognostic factors for acute large vessel occlusion with NIHSS 5 or lower., The Journal of Medical Investigation : JMI, 70, 1.2, 22-27, 2023. (要約) MCA occlusion is associated with poor prognosis, even with NIHSS score ??5, and d-IAS may provide a predictor. J. Med. Invest. 70 : 22-27, February, 2023. (キーワード) Humans / Tissue Plasminogen Activator / Stroke / Prognosis / Retrospective Studies / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164724 ● Search Scopus @ Elsevier (PMID): 37164724 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.22 (DOI: 10.2152/jmi.70.22, PubMed: 37164724)
14.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 循環器病を防ぐために徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 四国医学雑誌, 78, 5-6, 135-138, 2022年. (要約) Cerebrovascular and cardiovascular disease are the main causes of death in Japan. The leading causes of the need for long-term care in Japan are also cerebrovascular and cardiovascular disease, which together account for more than one-fourth of the total. The Cerebrovascular and Cardiovascular Disease Control Act, of Japanese national law, was promulgated by a legislative act in 2018. On the basis of the Cerebrovascular and Cardiovascular Disease Control Act, the Ministry of Health, Labour and Welfare, Japan, published the Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease (Japanese National Plan) in 2020. By the example of the Japanese National Plan, Tokushima prefecture established a cerebrovascular and cardiovascular disease countermeasure promotion plan to progress cerebrovascular and cardiovascular disease measures according to their own circumstances. One of the important measures of the plan is improving emergency transportation systems. Patients with intracranial large vessel occlusion strokes should be served by direct transfer to endovascular capable centers avoiding delays by misguided transfer to primary stroke centers. Considering the limited availability of endovascular capable centers, accurate identification of patients with high probability of having large vessel occlusion strokes in the prehospital setting is importance. To address this problem, we introduced prehospital scale called Field Assessment Stroke Triage for Emergency Destination (FAST-ED) on emergency transportation systems in Tokushima city. (キーワード) Cerebrovascular and cardiovascular disease / emergency transportation systems / prehospital scale (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050304183895271424 (CiNii: 1050304183895271424)
15.	亀井友志, 武藤浩平, 山本雄貴, 藤田浩司, 和泉唯信, 原倫世 : 重症筋無力症との鑑別を要したクッシング病の1例, 四国医学雑誌, 78, 5-6, 221-226, 2022年. (要約) The patient is a 77-year-old woman with a history of diabetes mellitus that was refractory to the medication and dietary restrictions. Four months prior to the admission, she developed a dropped head and ptosis that worsened in the evening. These symptoms were improved by the edrophonium test and the 3 Hz repetitive nerve stimulation testing was positive ; nevertheless, anti-acetylcholine and anti-muscle-specific tyrosine kinase antibodies were negative. Further examination demonstrated sustained hypokalemia and high levels of cortisol and ACTH. Moreover, CRH and high-dose dexamethasone suppression testings were positive and MRI demonstrated pituitary microadenoma. Based on these findings, she was subsequently diagnosed with Cushing's disease. After the resection of the pituitary tumor, ptosis improved with an alleviation of systemic edema, suggesting that it was caused by an eyelid edema. This case uniquely illustrates that Cushing's disease may mimic myasthenia gravis. Differentiation of the two disorders is crucial as treatment with steroids could compromise the interpretation of diagnostic testings for Cushing's disease and might result in a disease exacerbation. In this case, the history of treatment-refractory diabetes mellitus was helpful cue to differentiate the two disorders. (キーワード) Cushing's disease / Myasthenia gravis / Dropped head / Ptosis / Eyelid edema
16.	黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 山口泉, 島田健司, 兼松康久, 宮本健志, 髙木康志 : 脳静脈洞血栓症に対して経皮的血栓回収術を行った3例, 四国医学雑誌, 78, 5-6, 221-226, 2022年.
17.	山本雄貴, 山本伸昭, 黒田一駿, 和泉唯信, 兼松康久, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志 : 徳島市におけるアプリケーションを用いた脳主幹動脈閉塞診断スケールの活用,, 四国医学雑誌, 78, 5,6, 248-249, 2022年.
18.	Yu Hiramatsu, Yuji Okamoto, Akiko Yoshimura, JunHui Yuan, Masahiro Ando, Yujiro Higuchi, Akihiro Hashiguchi, Eiji Matsuura, Fumihito Nozaki, Tomohiro Kumada, Kei Murayama, Mikiya Suzuki, Yuki Yamamoto, Naoko Matsui, Yoshimichi Miyazaki, Masamitsu Yamaguchi, Youji Suzuki, Jun Mitsui, Hiroyuki Ishiura, Masaki Tanaka, Shinichi Morishita, Ichizo Nishino, Shoji Tsuji and Hiroshi Takashima : Complex hereditary peripheral neuropathies caused by novel variants in mitochondrial-related nuclear genes, Journal of Neurology, 269, 8, 4129-4140, 2022. (要約) Mitochondrial disorders are a group of clinically and genetically heterogeneous multisystem disorders and peripheral neuropathy is frequently described in the context of mutations in mitochondrial-related nuclear genes. This study aimed to identify the causative mutations in mitochondrial-related nuclear genes in suspected hereditary peripheral neuropathy patients. We enrolled a large Japanese cohort of clinically suspected hereditary peripheral neuropathy patients who were mutation negative in the prescreening of the known Charcot-Marie-Tooth disease-causing genes. We performed whole-exome sequencing on 247 patients with autosomal recessive or sporadic inheritance for further analysis of 167 mitochondrial-related nuclear genes. We detected novel bi-allelic likely pathogenic/pathogenic variants in four patients, from four mitochondrial-related nuclear genes: pyruvate dehydrogenase beta-polypeptide (PDHB), mitochondrial poly(A) polymerase (MTPAP), hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, beta subunit (HADHB), and succinate-CoA ligase ADP-forming beta subunit (SUCLA2). All these patients showed sensory and motor axonal polyneuropathy, combined with central nervous system or multisystem involvements. The pathological analysis of skeletal muscles revealed mild neurogenic changes without significant mitochondrial abnormalities. Targeted screening of mitochondria-related nuclear genes should be considered for patients with complex hereditary axonal polyneuropathy, accompanied by central nervous system dysfunctions, or with unexplainable multisystem disorders. (キーワード) Charcot-Marie-Tooth Disease / Coenzyme A / DNA, Mitochondrial / Humans / Mitochondrial Diseases / Mutation / Oxidoreductases (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00415-022-11026-w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35235001 ● Search Scopus @ Elsevier (PMID): 35235001 ● Search Scopus @ Elsevier (DOI): 10.1007/s00415-022-11026-w (DOI: 10.1007/s00415-022-11026-w, PubMed: 35235001)
19.	Koji Fukushima, Naoko Takamatsu, Yuki Yamamoto, Hiroki Yamazaki, Takeshi Yoshida, Yusuke Osaki, Shotaro Haji, Koji Fujita, Kazuma Sugie and Yuishin Izumi : Early diagnosis of amyotrophic lateral sclerosis based on fasciculations in muscle ultrasonography: A machine learning approach., Clinical Neurophysiology, 140, 136-144, 2022. (要約) We investigated 100 patients with ALS, including 50 with early-stage ALS within 9 months from onset, and 100 without ALS. Fifteen muscles were bilaterally observed for 10 s each and the presence of fasciculations was recorded. Hierarchical clustering and nominal logistic regression, neural network, or ensemble learning were applied to the training cohort comprising the early-stage ALS to develop MUS-based diagnostic models, and they were tested in the validation cohort comprising the later-stage ALS. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clinph.2022.06.005 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35772191 ● Search Scopus @ Elsevier (PMID): 35772191 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clinph.2022.06.005 (DOI: 10.1016/j.clinph.2022.06.005, PubMed: 35772191)
20.	Shinichi Matsumoto, Yuki Yamamoto, Koji Fujita, Ryosuke Miyamoto, Hidetaka Koizumi, Akihiro Tateishi, Naoaki Yamada and Yuishin Izumi : Truncal dystonia with isolated middle cerebral artery ischemia: A case report of revascularization therapy for dystonia., Surgical Neurology International, 13, 2022. (要約) Revascularization therapy improved CBF and truncal dystonia and could be a viable treatment option for dystonia with ischemia in the MCA region. Extensive cerebral ischemia can result in cortical inhibition loss or over-adapted cerebral plasticity and cause dystonia. Revascularization therapy may be useful for patients with dystonia and decreased CBF in the MCA region. (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_173_2022 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35509528 ● Search Scopus @ Elsevier (PMID): 35509528 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_173_2022 (DOI: 10.25259/SNI_173_2022, PubMed: 35509528)
21.	Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Shu Sogabe, Kenji Shimada, Yasushi Takagi and Yuishin Izumi : The claw sign predicts first-pass effect in mechanical thrombectomy for cerebral large vessel occlusion in the anterior circulation, Surgical Neurology International, 13, 72, 1-7, 2022. (要約) Mechanical thrombectomy (MT) is an effective treatment for acute cerebral large vessel occlusion (LVO). Complete recanalization of vessels in a single procedure is defined as the first-pass effect (FPE) and is associated with good prognosis. In this study, angiographic clot protruding sign termed the "claw sign," was examined as candidate preoperative imaging factor for predicting the FPE. We retrospectively analyzed data from 91 consecutive patients treated for acute LVO in the anterior circulation by MT between January 2014 and December 2019. The claw sign was defined as a thrombus that protruded proximally by more than half of the diameter of the parent artery. Radiological findings such as claw sign, clinical and etiological features, and outcomes were compared between groups with and without successful FPE. Multivariate analysis was conducted to evaluate perioperative factors associated with FPE. FPE was achieved in 26 of 91 (28.6%) patients and the claw sign was observed in 34 of 91 (37.4%) patients. The claw sign was significantly more frequent in the successful FPE group than in the failed FPE group (53.8% vs. 30.8%; = 0.040). After the multivariate analysis, the claw sign was the only pretreatment parameter that could predict FPE (odds ratio, 2.67; 95% confidence interval, 1.01-7.06; = 0.047). The claw sign is an angiographic imaging factor that might predict FPE after MT for anterior circulation acute ischemic stroke. (徳島大学機関リポジトリ) ● Metadata: 2010034 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_1160_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35242438 ● Search Scopus @ Elsevier (PMID): 35242438 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_1160_2021 (徳島大学機関リポジトリ: 2010034, DOI: 10.25259/SNI_1160_2021, PubMed: 35242438)
22.	Masaaki Korai, Yasuhisa Kanematsu, Izumi Yamaguchi, Tadashi Yamaguchi, Yuki Yamamoto, Nobuaki Yamamoto, Takeshi Miyamoto, Kenji Shimada, Junichiro Satomi, Mami Hanaoka, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi : Subarachnoid Hemorrhage Due to Rupture of Vertebral Artery Dissecting Aneurysms: Treatments, Outcomes, and Prognostic Factors, World Neurosurgery, 152, e86-e93, 2021. (要約) Mortality rate after subarachnoid hemorrhage due to rupture of vertebral artery dissecting aneurysms (VADAs) is high; endovascular coil trapping is the first-line therapy to prevent rerupture. To select optimal treatments, the positional relationship between the VADA and posterior inferior cerebellar artery (PICA) and the morphology of the contralateral vertebral artery must be considered, and outcome predictors of different treatment methods and their possible complications must be identified. We retrospectively studied 44 patients with ruptured VADAs who had undergone endovascular or surgical treatment. VADA morphology was assessed on conventional preoperative angiograms, and VADAs were categorized based on their site in relation to the PICA. VADA site, treatment method, and complications were used to identify prognostic factors. The sites of the 44 VADAs were PICA-proximal (n = 3), PICA-distal (n = 22), PICA-absent (n = 7), and PICA-involved (n = 12). Treatments included internal coil trapping (n = 30), proximal coil occlusion (n = 5), and stent placement (n = 3); surgical flow alteration via an occipital artery-PICA bypass and ligation at the proximal vertebral artery and the PICA origin was performed in 6 patients. Periprocedural rebleeding was associated with a poor outcome. Internal coil trapping prevented the rerupture of PICA-proximal and PICA-absent VADAs, and flow alteration prevented rerupture of PICA-involved VADAs; there were no complications directly attributable to these procedures. Periprocedural rebleeding was a poor prognostic factor. Internal trapping of PICA-proximal and PICA-absent VADAs and flow alteration in PICA-involved VADAs prevented rerupture. (キーワード) Adult / Aged / Aged, 80 and over / Aneurysm, Ruptured / Follow-Up Studies / Humans / Male / Middle Aged / Prognosis / Retrospective Studies / Subarachnoid Hemorrhage / Treatment Outcome / Vertebral Artery Dissection (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.wneu.2021.05.018 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34051365 ● Search Scopus @ Elsevier (PMID): 34051365 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2021.05.018 (DOI: 10.1016/j.wneu.2021.05.018, PubMed: 34051365)
23.	Yasuhisa Kanematsu, Kenji Shimada, Yoshiteru Tada, Masaaki Korai, Takeshi Miyamoto, Shu Sogabe, Izumi Yamaguchi, Yoko Ymamoto, Nobuaki Yamamoto, Yuki Yamamoto, Koichi Satoh and Yasushi Takagi : Coil embolization with overlapping horizontal low-profile stents to treat a giant thrombosed fetal posterior cerebral aneurysm using contralateral approach through anterior communicating artery: Case report., Surgical Neurology International, 12, 347, 2021. (要約) The treatment of internal carotid artery (ICA) - posterior communicating artery aneurysms (ICPC aneurysms) is challenging when a fetal posterior cerebral artery (PCA) arises from the saccular neck. This complex angioarchitecture renders endovascular approaches difficult. Giant thrombosed IC-PC aneurysms are also hard to treat by endovascular coiling because its flow-diversion effect is insufficient. We report the first case of a ruptured giant thrombosed IC-PC aneurysm associated with a fetal PCA that was successfully treated by coil embolization with retrograde overlap horizontal stenting using low-profile stents introduced through the contralateral ICA. The aneurysm was completely occluded and follow-up MRI scans demonstrated the reduction of the aneurysmal size. Our technique is advantageous because low-profile stents can be used to treat lesions not accessible with flow-diverter stents due their presence in complex angioarchitectures, and overlap stenting may have flow-diversion effects that can result in the complete occlusion of giant thrombosed aneurysms. (徳島大学機関リポジトリ) ● Metadata: 2012102 (出版サイトへのリンク) ● Publication site (DOI): 10.25259/SNI_533_2021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34345487 ● Search Scopus @ Elsevier (PMID): 34345487 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_533_2021 (徳島大学機関リポジトリ: 2012102, DOI: 10.25259/SNI_533_2021, PubMed: 34345487)
24.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki, Yuishin Izumi and Yasushi Takagi : Percutaneous Transluminal Angioplasty and Stenting Using an Aspiration Catheter, Journal of Neuroendovascular Therapy, 16, 5, 277-282, 2021. (要約) <p><b>Objective</b>: During percutaneous transluminal angioplasty (PTA) for the vertebral artery, occlusion of the subclavian artery using a balloon guiding catheter may be useful to prevent embolism of clots and/or debris distal to an atherosclerotic lesion. However, when placing a balloon guiding catheter at the intended vessels is difficult, it may be useful to use an aspiration catheter (AC) for mechanical thrombectomy as an intermediate catheter to suction way clots and/or debris. We report two cases in which PTA was performed for an atherosclerotic lesion at the intracranial vertebral artery using an AC, which ended without complications.</p><p><b>Case Presentations</b>: Case 1: A 74-year-old man presented with dysarthria and was admitted to our hospital. MRI revealed severe left vertebral artery stenosis and diffuse cerebral infarct areas at the territory of the posterior circulation. The patient had an abdominal aortic aneurysm and abnormally shaped left tortuous subclavian artery. Therefore, we performed PTA and stenting via the left brachial artery. We guided a 6-Fr long sheath to the left subclavian artery, and a 6-Fr AC for thrombectomy was guided through the long sheath to the V4 portion of the left vertebral artery. Thereafter, PTA was carried out under manual aspiration from the AC. As restenosis at the atherosclerotic lesion occurred after PTA, we performed stenting using a coronary stent system for this lesion under manual aspiration from the AC. No new infarct areas were observed on post-procedural MRI. Case 2: A 74-year-old woman presented with dysarthria and was admitted to our hospital. MRI demonstrated basilar artery occlusion and diffuse cerebral infarct areas at the territory of the posterior circulation. As her symptom worsened after admission, we performed urgent mechanical thrombectomy. We first performed thrombectomy using a stent retriever and then performed PTA and stenting (PTAS) for residual basilar artery stenosis via the AC under manual aspiration.</p><p><b>Conclusion</b>: When it is difficult to place a guiding catheter at the intended vessels during PTA, an AC may be useful to prevent distal embolization.</p> (キーワード) percutaneous transluminal angioplasty / aspiration catheter (出版サイトへのリンク) ● Publication site (DOI): 10.5797/jnet.cr.2021-0030 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390573593425698304 ● Search Scopus @ Elsevier (DOI): 10.5797/jnet.cr.2021-0030 (DOI: 10.5797/jnet.cr.2021-0030, CiNii: 1390573593425698304)
25.	Nobuaki Yamamoto, Yuishin Izumi, Yuki Yamamoto, K Kuroda, Izumi Yamaguchi, Shu Sogabe, Takeshi Miyamoto, Kenji Shimada, Yasuhisa Kanematsu, Ryoma Morigaki and Yasushi Takagi : Factors associated with DWI-ASPECTS score in patients with acute ischemic stroke due to cerebral large vessel occlusion, Clinical Neurology and Neurosurgery, 199, 106316, 2020. (要約) The Alberta Stroke Program Early CT score (ASPECTS) of patients with acute ischemic stroke at the time of admission varies. It is crucial to select appropriate methods of treatment, such as recombinant tissue-plasminogen activator, and/or endovascular thrombectomy. According to the recent guidelines, endovascular thrombectomy for patients with large vessel occlusion (LVO) and lesion of ischemic tissue that was not yet infarcted is effective. This result demonstrates the importance of patient selection based on neuroradiological imaging. However, there are many patients who are judged as ineligibility for recanalization therapy because of presence of large ischemic core, indicating unfavorable ASPECTS, at the time of admission. We investigated the factors associated with favorable diffusion-weighted image (DWI)-ASPECTS score at the time of admission. We studies patients with LVO within 24 h from onset who were admitted into our hospital. We divided them into two groups, with favorable DWI-ASPECTS (≥6), and unfavorable DWI-ASPECTS (<6) at the time of admission. We investigated factors associated with favorable DWI-ASPECTS by evaluation of our patients' severity of clinical symptom, etiology, and radiological findings. This study showed that mild white matter lesion (Fazekas scale ≤1), absence of internal carotid artery (ICA) occlusion and cardioembolic stroke were independent factor of favorable DWI-ASPECTS at the time of admission. (odds ratio 12.92, p < 0.001, odds ratio 0.31, p = 0.001, odds ratio 0.16, p = 0.001, respectively) CONCLUSIONS: Absence of severe white matter lesion, cardioembolic stroke, and ICA occlusion might be associated with favorable DWI-ASPECTS at the time of admission. (キーワード) Aged / Aged, 80 and over / Brain Ischemia / Cerebrovascular Disorders / Diffusion Magnetic Resonance Imaging / Female / Humans / Ischemic Stroke / Male / Middle Aged / Patient Admission / Prospective Studies / Retrospective Studies / Severity of Illness Index (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.clineuro.2020.106316 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33161217 ● Search Scopus @ Elsevier (PMID): 33161217 ● Search Scopus @ Elsevier (DOI): 10.1016/j.clineuro.2020.106316 (DOI: 10.1016/j.clineuro.2020.106316, PubMed: 33161217)
26.	Nobuaki Yamamoto, Yuki Yamamoto, Izumi Yamaguchi, Manabu Ishihara, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion, Journal of Clinical Neuroscience, 70, 67-71, 2019. (要約) Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion (ELVO) is standard treatment, the benefits, however, are highly time-sensitive. After patient eligibility for reperfusion therapy is determined by conventional radiological examinations, the time to be transferred from the department of radiological examination to angiography-suites is critical. We speculated that the time required for the diagnosis of AIS might be reduced if we could determine MT eligibility in patients with ELVO at angiography-suites. Modern angiography-suites with flat panel detectors can perform cone beam (CB)-CT. We performed CB-CTA using intravenous injection of contrast agent to evaluate occlusion sites, collateral score, and construction of vessels distal to occlusion sites and determined if CB-CTA could be useful to evaluate patients with ELVO. We included 15 patients with ELVO diagnosed by conventional MRI or CT/CTA, and investigated whether CB-CTA was reliable to diagnose occlusion sites. We also studied if collateral score on CB-CTA was associated with prognosis after successful reperfusion by MT by comparison between favorable (modified Rankin scale (mRS) 0-2), and unfavorable outcome group (mRS 3-6). There was strong agreement of occlusion sites between CB-CTA and conventional radiological examination (κ = 0.80). Collateral score determined by CB-CTA was significantly different between favorable outcome and unfavorable outcome group (median collateral score 2.3 v.s. 1.3, p = 0.040). Although prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO. (キーワード) Aged / Aged, 80 and over / Brain Ischemia / Carotid Artery Thrombosis / Computed Tomography Angiography / Contrast Media / Female / Humans / Infarction, Middle Cerebral Artery / Injections, Intravenous / Male / Middle Aged / Prognosis / Reperfusion / Retrospective Studies / Thrombectomy / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jocn.2019.08.078 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31445814 ● Summary page in Scopus @ Elsevier: 2-s2.0-85070874852 (DOI: 10.1016/j.jocn.2019.08.078, PubMed: 31445814, Elsevier: Scopus)

学術論文(紀要・その他):

1.	Izumi Yamaguchi, Yasuhisa Kanematsu, Kenji Shimada, Nobuaki Yamamoto, Masaaki Korai, Kazuhisa Miyake, Takeshi Miyamoto, Shu Sogabe, Eiji Shikata, Manabu Ishihara, Yuki Yamamoto, Kazutaka KURODA and Yasushi Takagi : Evaluation of Serial Intra-Arterial Indocyanine Green Videoangiography in the Surgical Treatment of Cranial and Craniocervical Junction Arteriovenous Fistulae: A Case Series, Operative Neurosurgery, 25, 3, 292-300, 2023. (要約) Intravenous indocyanine green (IV-ICG) videoangiography is commonly performed to detect blood flow in the microscopic view. However, intra-arterial ICG (IA-ICG) videoangiography provides high-contrast imaging, repeatability within a short period of time, and clear-cut separation of the arterial and venous phases compared with IV-ICG. These features are useful for detecting retrograde venous drainage (RVD) and shunt occlusion in arteriovenous fistulae (AVF) surgery. This study aimed to investigate whether IA-ICG videoangiography can be repeatable within a short period of time and be useful for detecting RVD and shunt occlusion in cranial- and craniocervical junction (CCJ)-AVF surgery. Between January 2012 and December 2022, 50 patients were treated with endovascular or surgical intervention for cranial- and CCJ-AVF at Tokushima University Hospital. Of these, 5 patients (6 lesions) underwent open surgery with IA-ICG videoangiography in a hybrid operating room. We analyzed the data of these 5 patients (6 lesions). There were 4/patient (median, range 2-12) and 3.5/lesion (median, range 2-10) intraoperative IA-ICG runs. IA-ICG videoangiography detected RVD in all patients. Clearance of IA-ICG-induced fluorescence was achieved within 30 seconds in all patients at each region of interest. After the disconnection of the fistulae, IA-ICG videoangiography and intraoperative digital subtraction angiography (DSA) confirmed the disappearance of RVD in all patients. There were no complications associated with IA-ICG videoangiography. This study showed that IA-ICG videoangiography is repeatable within a short period of time before and after obliteration and can be useful for detecting RVD and shunt occlusion in cranial- and CCJ-AVF surgery. IA-ICG videoangiography also allows intraoperative DSA studies in a hybrid operating room. Considering the recent advancements in hybrid operating rooms, combining IA-ICG videoangiography with intraoperative DSA is a useful strategy for cranial- and CCJ-AVF surgery. (キーワード) Humans / Indocyanine Green / Coloring Agents / Neurosurgical Procedures / Vascular Surgical Procedures / Arteries (出版サイトへのリンク) ● Publication site (DOI): 10.1227/ons.0000000000000796 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37345942 ● Summary page in Scopus @ Elsevier: 2-s2.0-85168222953 (DOI: 10.1227/ons.0000000000000796, PubMed: 37345942, Elsevier: Scopus)

総説・解説:

1.	藤田浩司, 山本雄貴, 山本伸昭 : 放射線科医が知っておくべき脳血管障害診療 update】特殊な脳血管障害の診断 CADASIL,CARASIL, 悪性腫瘍に伴う脳梗塞,血管炎,脳アミロイド血管症, 臨床画像, 36, 92-103, 2020年4月. (出版サイトへのリンク) ● Publication site (DOI): 10.18885/ci.0000000269 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390572174450972800 ● Search Scopus @ Elsevier (DOI): 10.18885/ci.0000000269 (DOI: 10.18885/ci.0000000269, CiNii: 1390572174450972800)

国際会議:

1.	Kenji Shimada, Izumi Yamaguchi, Yuki Yamamoto, Takeshi Miyamoto, Masaaki Korai, Nobuaki Yamamoto, Yasuhisa Kanematsu and Yasushi Takagi : Efficacy of Intra-arterial Indocyanine Green Videoangiography in Vascular Malformation Surgery in a Hybrid Operating Room, AACNS2024, Kaohsiung, Nov. 2024.

国内講演発表:

1.	十川和樹, 中尾遼平, 谷美紀, 花田健太, 福本竜也, 山本雄貴, 山﨑博輝, 大崎裕亮, 髙松直子, 山本伸昭, 松井尚子, 和泉唯信 : フィッシャー症候群の臨床的・電気生理学的特徴, 第67回日本神経学会学術大会, 2026年5月.
2.	中尾遼平, 十川和樹, 笠屋心音, 谷美紀, 髙松直子, 花田健太, 福本竜也, 山本雄貴, 山﨑博輝, 大崎裕亮, 山本伸昭, 松井尚子, 和泉唯信 : COVID-19流行に伴うギラン/バレー症候群の疫学変化, 第67回日本神経学会学術大会, 2026年5月.
3.	山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : Bifurcation occlusionに対するDual stent retrieverの有用性, 第67回日本神経学会学術大会, 2026年5月.
4.	十川和樹, 福本竜也, 山本雄貴, 山﨑博輝, 宮本亮介, 藤田浩司, 佐藤健太, 松井尚子, 和泉唯信 : 難治性てんかん重積および両側線条体病変を呈しリツキシマブが奏効した自己免疫性脳炎の1例, 第118回日本神経学会中国・四国地方会, 2025年12月.
5.	遠藤裕美, 福本竜也, 山本雄貴, 山﨑博輝, 大崎裕亮, 藤田浩司, 松井尚子, 和泉唯信 : 胸腺腫合併重症筋無力症にMorvan症候群を併発しエフガルチビモドが奏効した1例, 第118回日本神経学会中国・四国地方会, 2025年12月.
6.	花田健太, 山本雄貴, 木原直輝, 橘このか, 宮本亮介, 藤田浩司, 松井尚子, 和泉唯信 : 急速進行性認知症を呈し免疫療法が奏効した抗NAE抗体陽性脳症の1例, 一般社団法人日本内科学会第133回四国地方会, 2025年11月.
7.	福本竜也, 大崎裕亮, 遠藤裕美, 山本雄貴, 谷美紀, 山﨑博輝, 松井尚子, 和泉唯信 : Isaacs症候群を合併した胸腺腫関連重症筋無力症の一例，―After discharge/SIRDの議論を中心に―, 第55回日本臨床神経生理学会学術大会ワークショップ2, 2025年11月.
8.	花田健太, 大崎裕亮, 山本雄貴, 井上宗一郎, 福本竜也, 山﨑博輝, 髙松直子, 土師正太郎, 佐光亘, 和泉唯信 : 筋萎縮性側索硬化症における機能予後予測マーカーとしての尺骨運動神経の遠位潜時, 第55回日本臨床神経生理学会学術大会, 2025年11月.
9.	木原直輝, 松原知康, 山本雄貴, 山﨑博輝, 大崎裕亮, 宮本亮介, 森本展年, 藤田浩司, 和泉唯信 : 原発性側索硬化症と右側頭葉優位前頭側頭型認知症の合併を認め，新規TBK1遺伝子のバリアントが判明した1例, 第117回日本神経学会中国・四国地方会, 2025年6月.
10.	中尾遼平, 山本雄貴, 山﨑博輝, 宮本亮介, 松井尚子, 和泉唯信 : 前庭機能障害を伴いMPZ遺伝子の新規バリアントを認めたCharcot-Marie-Tooth病の1B型の1例, 第117回日本神経学会中国・四国地方会, 2025年6月.
11.	遠藤裕美, 木原直輝, 山本雄貴, 尾崎領彦, 藤田浩司, 松井尚子, 西岡安彦, 和泉唯信 : ニボルマブ・イピリムマブ併用療法中に多発性中枢神経病変を呈した免疫関連有害事象の1例, 日本内科学会第132回四国地方会, 2025年5月.
12.	山本雄貴, 山本伸昭, 島田健司, 兼松康久, 宮本健志, 高麗雅章, 髙木康志, 和泉唯信 : FAST-ED TokushimaによるLVO患者選定とICT活用効果: 運用開始後3年の報告, 徳島脳血管障害カンファレンス, 2025年5月.
13.	山本雄貴, 山本伸昭, 島田健司, 宮本健志, 高麗雅章, 髙木康志, 和泉唯信 : 50万人規模の地方医療圏におけるICTを活用したLVOスケールの運用 2年間の成績, 第50回日本脳卒中学会学術集会, 2025年3月.
14.	山本雄貴, 山本伸昭, 島田健司, 兼松康久, 宮本健志, 高麗雅章, 髙木康志, 和泉唯信 : FAST-ED TokushimaによるLVO患者選定とICT活用効果: 運用開始後3年の報告, 徳島脳卒中研究会, 2025年2月.
15.	宮本健志, 羽星辰哉, 手島奈津美, 山本雄貴, 高麗雅章, 山本伸昭, 島田健司, 兼松康久, 髙木康志 : 視力障害で発症した上矢状静脈洞部硬膜動静脈瘻に対して経静脈的塞栓術を行った一例, 第40回日本脳神経血管内治療学会学術集会, 2024年11月.
16.	高麗雅章, 兼松康久, 宮本健志, 手島奈津美, 山本雄貴, 山本伸昭, 石原学, 島田健司, 髙木康志 : 破裂動脈瘤に対してコイル塞栓術を施行し再治療を要した症例の特徴, 第40回日本脳神経血管内治療学会学術集会, 2024年11月.
17.	松井尚子, 木原直樹, 山﨑博輝, 山本雄貴, 佐藤健太, 藤田浩司, 和泉唯信 : 卵巣奇形腫の診断までに時間を要した抗NMDA受容体脳炎の1例, 第36回日本神経免疫学会学術集会, 2024年10月.
18.	山本雄貴, 山本伸昭, 島田健司, 宮本健志, 高麗雅章, 髙木康志, 和泉唯信 : 徳島県東部医療圏におけるICTを活用したLVOスケールの運用2年間の成績, 第26回中国四国脳卒中研究会, 2024年9月.
19.	富永洋介, 高麗雅章, 宮本健志, 山本雄貴, 山本伸昭, 島田健司, 髙木康志 : 脳梗塞で発症した大型部分血栓化後大脳動脈瘤の一例, 第33回NPO法人日本脳神経血管内治療学会中国四国地方会, 2024年9月.
20.	佐原和真, 山本雄貴, 田村哲也, 新野清人 : 腰椎ドレナージ後の続発性脳脊髄液漏出症の一例, STROKE 2024, 2024年3月.
21.	松井尚子, 望月歩, 武藤浩平, 山本雄貴, 和泉唯信 : 当院における難治MG例の検討, 第35回日本神経免疫学会学術集会, 2023年9月.
22.	山本伸昭, 黒田一駿, 山本雄貴, 和泉唯信, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志 : First pass TICI2B患者の追加治療における意義, 第64回日本神経学会学術大会, 2023年5月.
23.	山本雄貴, 山本伸昭, 黒田一駿, 松田知大, 島田健司, 兼松康久, 髙木康志, 和泉唯信 : 頸動脈浮遊血栓に対する，ステントトリーバーによる血栓回収とCASの併用, 第64回日本神経学会学術大会, 2023年5月.
24.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第48回日本脳卒中学会学術集会, 2023年3月.
25.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, STROKE2023, 2023年3月.
26.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での低ASPECTS症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 第48回日本脳卒中学会学術集会, 2023年3月.
27.	山上圭, 花田健太, 山本雄貴, 山﨑博輝, 大崎裕亮, 松井尚子, 藤田浩司, 和泉唯信 : 尿閉・便秘を呈したフィッシャー症候群の34歳男性例, 第112回日本神経学会中国・四国地方会, 2022年12月.
28.	黒田一駿, 山本雄貴, 山本伸昭, 松田知大, 板東康司, 山口泉, 高麗雅章, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 広範囲シャントを伴った横静脈洞部硬膜動静脈瘻に対して血管内治療を行った1例, 第112回日本神経学会中国・四国地方会, 2022年12月.
29.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 和泉唯信, 髙木康志 : 当院の主幹動脈閉塞低ASPECT症例の拡散強調画像に対するRAPIDでの後方視的定量評価, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
30.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 地方都市における救急医療連携アプリケーションを用いたLVO診断スケールの活用, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
31.	山本伸昭, 黒田一駿, 山本雄貴, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 病院前スケール，iSchemaView RAPID導入前後の比較検討, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
32.	山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 兼松康久, 髙木康志, 和泉唯信 : 9Fr long sheathを用いた巨大血栓によるLVO治療例, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
33.	高麗雅章, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 石原学, 山口泉, 山本雄貴, 黒田一駿, 髙木康志 : 当院での急性期脳底動脈閉塞に対する血管内治療成績, 第38回NPO法人日本脳神経血管内治療学会学術集会, 2022年11月.
34.	曽我部周, 宮本健志, 山口泉, 高麗雅章, 島田健司, 兼松康久, 山本雄貴, 山本伸昭, 原田雅史, 和泉唯信, 髙木康志 : 当院での主幹動脈閉塞-低ASPECT症例の拡散強調画像に対するRAPIDを用いた後方視的定量評価, 日本脳神経外科学会第81回学術総会, 2022年9月.
35.	兼松康久, 山口泉, 石原学, 曽我部周, 高麗雅章, 多田恵曜, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 佐藤健太, 島谷佳光, 亘雄也, 田村哲也, 新野清人, 髙木康志 : 徳島県総合メディカルゾーンでの急性期脳卒中診療の取り組み, 日本脳神経外科学会第81回学術総会, 2022年9月.
36.	山本雄貴, 兼松康久, 山本伸昭, 黒田一駿, 山口泉, 曽我部周, 高麗雅章, 島田健司, 髙木康志, 和泉唯信 : 徳島市におけるアプリケーションを用いたLVO診断スケールの活用(FAST-ED Tokushima), 第24回中国四国脳卒中研究会, 2022年9月.
37.	兼松康久, 山口泉, 石原学, 曽我部周, 宮本健志, 高麗雅章, 島田健司, 黒田一駿, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 徳島県循環器病推進計画の中での急性期脳卒中診療の取り組み, 徳島医学会学術集会, 2022年7月.
38.	花田健太, 山本雄貴, 大崎裕亮, 島かさ音, 武藤浩平, 宮本亮介, 藤田浩司, 和泉唯信 : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第111回日本神経学会中国・四国地方会, 2022年6月.
39.	花田健太, 山本雄貴, 大崎裕亮, 島かさ音, 武藤浩平, 宮本亮介, 藤田浩司, 和泉唯信 : Ocular flutterと体幹優位の運動失調を認めた抗NMDA受容体抗体陽性の若年女性例, 第63回日本神経学会学術大会, 2022年5月.
40.	福島功士, 高松直子, 山本雄貴, 山﨑博輝, 吉田剛, 土師正太郎, 大崎裕亮, 藤田浩司, 杉江和馬, 和泉唯信 : 筋超音波検査の線維束性収縮に基づく筋萎縮性側索硬化症の診断マーカー, 第63回日本神経学会学術大会, 2022年5月.
41.	山本雄貴, 山本伸昭, 兼松康久, 黒田一駿, 藤田浩司, 髙木康志, 和泉唯信 : 徳島市におけるアプリケーションを用いた病院前脳主幹動脈閉塞診断スケールの活用, 第63回日本神経学会学術大会, 2022年5月.
42.	山本伸昭, 黒田一駿, 山本雄貴, 兼松康久, 森垣龍馬, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞に対する血行再建術において有効再開通が得られた患者の予後関連因子, 第63回日本神経学会学術大会, 2022年5月.
43.	曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : open-cell stentにclosed-cell stentをオーバーラップさせたCASの治療成績, STROKE2022, 2022年3月.
44.	山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 : 開頭下にLabbe静脈を直線穿刺することで治療し得たTSS d-AVFの1例, 近畿脳神経血管内手術法ワークショップ, 2022年1月.
45.	山口泉, 兼松康久, 島田健司, 山本伸昭, 曽我部周, 宮本健志, 石原学, 山本雄貴, 髙木康志 : 開頭下にLabbe静脈の直線穿刺によるTVEを行ったTSS d-AVFの1例, 第92回日本脳神経外科学会中国四国支部会, 2021年12月.
46.	曽我部周, 兼松康久, 山口泉, 四方英二, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : 一期的にopen-cell stentにclosed-cell stentを重ねたCASの初期治療成績, 日本脳神経血管内治療学会, 2021年11月.
47.	宮本健志, 曽我部周, 兼松康久, 四方英二, 山口泉, 石原学, 島田健司, 山本雄貴, 山本伸昭, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞に対して急性期再開通療法後MRIのRibbon signの特徴, 日本脳神経血管内治療学会, 2021年11月.
48.	兼松康久, 金澤裕樹, 島田健司, 曽我部周, 宮本健志, 石原学, 四方英二, 山口泉, 多田恵曜, 山本雄貴, 山本伸昭, 原田雅史, 髙木康志 : CEST MRIを用いた頚動脈プラーク診断 Chemical exchange saturation transfer MRI for carotid plaque imaging, NMC Case Report Journal, 2021年10月.
49.	曽我部周, 兼松康久, 山口泉, 宮本健志, 島田健司, 山本雄貴, 山本伸昭, 髙木康志 : 当院でのopen-cell stentとclosed-cell stentの2枚重ねでのCASの治療成績, NMC Case Report Journal, 2021年10月.
50.	山口泉, 兼松康久, 島田健司, 山本伸昭, 宮本健志, 曽我部周, 石原学, 山本雄貴, 髙木康志 : 硬膜動静脈瘻の診断におけるArterial spin-labelingの有用性の検討 Usefulness of Arterial Spin-Labeling for diagnosis of dural arteriovenous fistulae, 日本脳神経外科学会第80回学術総会, 2021年10月.
51.	山本伸昭, 山本雄貴, 黒田一駿, 山口泉, 曽我部周, 島田健司, 兼松康久, 和泉唯信, 髙木康志 : 脳主幹動脈閉塞における有効再開通が得られた患者における予後関連因子, 第23回中国四国脳卒中研究会, 2021年9月.
52.	山本雄貴, 山本伸昭, 黒田一駿, 山口泉, 宮本健志, 島田健司, 髙木康志, 和泉唯信 : 血栓回収療法におけるFirst Pass Effect達成を予測する画像因子の探索, 第62回日本神経学会学術大会, 2021年5月.
53.	山本雄貴, 山本伸昭, 和泉唯信 : 血栓回収療法における血栓突出サインはFirst Pass Effect達成と関連する, 第46回日本脳卒中学会学術集会, 2021年3月.
54.	兼松康久, 島田健司, 曽我部周, 宮本健志, 石原学, 山口泉, 山本雄貴, 山本伸昭, 髙木康志 : 当施設における巨大血栓化脳動脈瘤に対する治療成績, 第46回日本脳卒中学会学術集会, 2021年3月.
55.	宮本健志, 曽我部周, 兼松康久, 島田健司, 山口泉, 山本伸昭, 山本雄貴, 和泉唯信, 髙木康志 : 脳梗塞急性期再開通療法後MRIの急性期ribbon signの特徴, 第46回日本脳卒中学会学術集会, 2021年3月.
56.	柿原紋太, 野崎夏江, 兼本ひろみ, 津田恵, 山本恭代, 山本雄貴, 山本伸昭, 石原学, 島田健司, 兼松康久, 西京子, 加藤真介, 髙木康志 : 徳島大学病院脳卒中センター(SCU)における排尿ケアチーム介入後の下部尿路機能障害の現状, 第45回日本脳卒中学会総会(web開催), 2020年8月.
57.	石原学, 兼松康久, 山本伸昭, 宮本健志, 高麗雅章, 島田健司, 山本雄貴, 大藤純, 髙木康志 : NIHSS 5点以下の軽症脳主幹動脈閉塞症例における予後因子, 日本脳神経外科学会第78回学術集会, 2019年10月.

その他・研究会:

1.	武藤浩平, 砂田陽二郎, 山本雄貴, 山﨑博輝, 多田恵曜, 高橋幸利, 藤田浩司, 和泉唯信 : 予後不良であったsubacute encephalopathy with seizures in alcoholics syndrome (SESA症候群)の1例, 第11回全国てんかんセンター協議会総会徳島大会2024, 2024年3月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

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特任助教 : 山本雄貴

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 山本 雄貴

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 山本雄貴