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Tokushima UniversityGraduate School of Biomedical Sciences歯学域Oral ScienceBasic DentistryDepartment of Oral Microbiology
Tokushima UniversityFaculty of DentistryCourse in DentistryBasic Oral SciencesOral Microbiology
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Research

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Academic Paper (Judged Full Paper):

1. Yuka Hiroshima, Rie Kido, Jun-ichi Kido, Mika Bandou, Kaya Yoshida, Akikazu Murakami and Yasuo Shinohara :
Synthesis of secretory leukocyte protease inhibitor using cell-free protein synthesis system,
Odontology, 2024.
2. Yasufumi Nishikawa, Yoritoki Tomotake, Hiromichi Kawano, Koji Naruishi, Jun-ichi Kido, Yuka Hiroshima, Akikazu Murakami, Tetsuo Ichikawa and Hiromichi Yumoto :
Effects of Candidalysin Derived from Candida albicans on the Expression of Pro-Inflammatory Mediators in Human Gingival Fibroblasts,
International Journal of Molecular Sciences, Vol.24, No.4, 3256, 2023.
(Tokushima University Institutional Repository: 118834,   DOI: 10.3390/ijms24043256,   PubMed: 36834667)
3. Yuta Uemura, Yuka Hiroshima, Ayano Tada, Keiji Murakami, Kaya Yoshida, Yuji Inagaki, Tomomi Kuwahara, Akikazu Murakami, Hideki Fujii and Hiromichi Yumoto :
Porphyromonas gingivalis Outer Membrane Vesicles Stimulate Gingival Epithelial Cells to Induce Pro-Inflammatory Cytokines via the MAPK and STING Pathways,
Biomedicines, Vol.10, No.10, 2643, 2022.
(Tokushima University Institutional Repository: 117616,   DOI: 10.3390/biomedicines10102643,   PubMed: 36289904)
4. Narutoshi Tsukahara, Akikazu Murakami, Maiko Motohashi, Hiroshi Nakayama, Yoshiro Kondo, Yuji Ito, Takachika Azuma and Hidehiro Kishimoto :
An alpaca single-domain antibody (VHH) phage display library constructed by CDR shuffling provided high-affinity VHHs against desired protein antigens.,
International Immunology, Vol.34, No.8, 421-434, 2022.
(DOI: 10.1093/intimm/dxac022,   PubMed: 35689594)
5. Naoto Okada, Akikazu Murakami, Masami Satou, Shingen Nakamura, Shiroh Fujii, Kimiko Sogabe, Mamiko Takahashi, Asami Okada, Akane Abe, Hideki Fujii, Masahiro Abe, Momoyo Azuma and Keisuke Ishizawa :
First reported case of Lachnoanaerobaculum gingivalis bacteremia in an acute myeloid leukemia patient with oral mucositis during high dose chemotherapy.,
Anaerobe, Vol.76, 2022.
(DOI: 10.1016/j.anaerobe.2022.102610,   PubMed: 35811059)
6. Muhammad Reza Pahlevi, Keiji Murakami, Yuka Hiroshima, Akikazu Murakami and Hideki Fujii :
pruR and PA0065 Genes Are Responsible for Decreasing Antibiotic Tolerance by Autoinducer Analog-1 (AIA-1) in Pseudomonas aeruginosa,
Antibiotics, Vol.11, No.6, 773, 2022.
(Tokushima University Institutional Repository: 117279,   DOI: 10.3390/antibiotics11060773,   PubMed: 35740179)
7. Akihiro Nishiguchi, Akikazu Murakami, Takachika Azuma and Masayuki Oda :
A Trade-off Between Thermostability and Binding Affinity of Anti-(4-hydroxy-3-nitrophenyl)Acetyl Antibodies During the Course of Affinity Maturation.,
The Protein Journal, Vol.41, No.2, 293-303, 2022.
(DOI: 10.1007/s10930-022-10053-w,   PubMed: 35501455)
8. Akihito Inoue, Takanobu Yasuda, Bo Zhu, Tetsuya Kitaguchi, Akikazu Murakami and Hiroshi Ueda :
Evaluation and selection of potent fluorescent immunosensors by combining fluorescent peptide and nanobodies displayed on yeast surface.,
Scientific Reports, Vol.11, No.1, 2021.
(Tokushima University Institutional Repository: 117719,   DOI: 10.1038/s41598-021-02022-7,   PubMed: 34799644)
9. Emina Ikeuchi, Daisuke Kuroda, Makoto Nakakido, Akikazu Murakami and Kouhei Tsumoto :
H antibodies.,
Scientific Reports, Vol.11, No.1, 2021.
(DOI: 10.1038/s41598-021-98977-8,   PubMed: 34663870)
10. Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Mikio Suzuki, Narutoshi Tsukahara, Akikazu Murakami, Asanori Kiyuna, Shinya Agena, Katsunori Tanaka, Narumi Hasegawa, Junko Kawakami, Akira Ganaha, Hiroyuki Maeda and Hitoshi Hirakawa :
Development of Antibodies against HPV-6 and HPV-11 for the Study of Laryngeal Papilloma.,
Viruses, Vol.13, No.10, 2021.
(Tokushima University Institutional Repository: 117725,   DOI: 10.3390/v13102024,   PubMed: 34696453)
11. Taro Ikegami, Hitoshi Hirakawa, Narutoshi Tsukahara, Akikazu Murakami, Norimoto Kise, Asanori Kiyuna, Takayoshi Kosugi, Shinya Agena, Hidetoshi Kinjyo, Narumi Hasegawa, Masatomo Touyama, Shunsuke Kondo, Hiroyuki Maeda, Mikio Suzuki and Akira Ganaha :
Coordinated Expression of HPV-6 Genes with Predominant E4 and E5 Expression in Laryngeal Papilloma.,
Microorganisms, Vol.9, No.3, 2021.
(DOI: 10.3390/microorganisms9030520,   PubMed: 33802595)
12. Chathuni Jayathilake, Shigefumi Kumachi, Hidenao Arai, Maiko Motohashi, Takuya Terai, Akikazu Murakami and Naoto Nemoto :
In vitro selection of anti-gliadin single-domain antibodies from a naïve library for cDNA-display mediated immuno-PCR.,
Analytical Biochemistry: Methods in the Biological Sciences, Vol.589, 2019.
(DOI: 10.1016/j.ab.2019.113490,   PubMed: 31678363)
13. Yukiko Nishi, Akikazu Murakami, Yuko Murayama, Narutoshi Tsukahara, Shiki Okamoto, Sawako Nakachi, Kazuho Morichika, Keita Tamaki, Hirofumi Noguchi, Masayuki Matsushita, Ken-Nosuke Karube, Takuya Fukushima, Satoko Morishima, Hidehiro Kishimoto and Hiroaki Masuzaki :
Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.,
Transplant Immunology, Vol.55, 2019.
(DOI: 10.1016/j.trim.2019.03.004,   PubMed: 30946889)

Proceeding of International Conference:

1. Raras Ajeng Enggardipta, Minato Akizuki, Kazumitsu Sekine, Kenichi Hamada, Akikazu Murakami and Hiromichi Yumoto :
The preliminary study of chitosan nanoparticles as antibacterial agent on Enterococcus faecalis biofilm,
19th Scientific Meeting and Refresher Course in Dentistry (Jakarta, Indonesia), Feb. 2023.

Proceeding of Domestic Conference:

1. 西松 佳苗, 清水 日向, 中村 大輔, 植村 勇太, Yuji Inagaki, Yuka Hiroshima, Jun-ichi Kido, Akikazu Murakami and Hiromichi Yumoto :
Porphyromonas gingivalis由来OMVsは破骨細胞の分化と歯槽骨吸収に関与する,
四国歯学会第61回例会, Mar. 2023.
2. 仲村 大輔, 植村 勇太, Yuka Hiroshima, Keiji Murakami, Akikazu Murakami and Hiromichi Yumoto :
Porphyromonas gingivalis 由来OMVsは破骨細胞の分化と歯槽骨吸収に関与する,
第75回日本細菌学会中国・四国支部総会(岡山・WEB), Oct. 2022.
3. SATOH Tomomi, Yuka Hiroshima, Akikazu Murakami, Hideki Fujii, Akiko Sakurai, Keiko Kataoka and Keiji Murakami :
カタラーゼをコードするkatA/katB遺伝子が及ぼす緑膿菌の抗菌薬抵抗性における影響,
第45回徳島県医学検査学会, Dec. 2021.

Et cetera, Workshop:

1. 立山 実弥, 田端 千歳, Akikazu Murakami and Hideki Fujii :
口腔細菌に対する天然バクテリオファージの単離技術の最適化,
Shikoku Dental Research,
2. Akikazu Murakami and Yusuke Nakashima :
合成ライブラリー法と分子進化法による単ドメイン抗体の産業利用,
酵素工学ニュース, No.85, 21-25, Apr. 2022.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • VHH抗体の欠点を克服するヘテロ2量体化「挟み込み」抗体の研究 (Project/Area Number: 20K05235 )
  • Immunological mechanism of action of bacteriophage-based vaccines and its application for in vitro immunization (Project/Area Number: 19K06386 )
  • Immunological mechanism for M13-phage-based vaccine immunogenicity and its application. (Project/Area Number: 16K08024 )
  • Single cell screening of the curvature recognition protein group using a 3D micropattern (Project/Area Number: 15K14493 )
  • Development of the rapid mass extraction system for adipose derived stem cells by using micro-patterned scaffold (Project/Area Number: 15H03008 )
  • The control mechanism of B cells activation due to pKnox1 homeodomain transcription factor (Project/Area Number: 24790481 )
  • Search by Researcher Number (00733635)