Tokushima University / Educator and Researcher Directory --- Saijo, Yasuyo

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ 先端医学教育研究プロジェクト ⟩
Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ Medical Science ⟩ Pathological Sciences ⟩ Department of Molecular Pathology ⟩
Tokushima University ⟩ Faculty of Medicine ⟩ School of Medicine ⟩ Course of Diseased Organ and Repair Medicine ⟩ Molecular Pathology ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Minoru Matsumoto, Takuya Ohmura, Yuto Hanibuchi, Mayuko Ichimura-Shimizu, Yasuyo Saijo, Hirohisa Ogawa, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto and Takeshi Oya : AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma., Cancer Medicine, 2023. (Summary) Despite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by focusing on AIRE, an mTEC-specific transcriptional regulator that is required for immunological self-tolerance. We found that a large proportion of TCs expressed AIRE with typical nuclear dot morphology by immunohistochemistry. AIRE expression in TCs was supported by the RNA-seq data in the TCGA-THYM database. Furthermore, our bioinformatics approach to the recent single-cell RNA-seq data on human thymi has revealed that TCs hold molecular characteristics of multiple mTEC subpopulations. In contrast, TCs lacked the gene signatures for cTECs. We propose that TCs are tumors derived from mTECs. (Link to Publication Site) ● Publication site (DOI): 10.1002/cam4.5777 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36912123 ● Search Scopus @ Elsevier (PMID): 36912123 ● Search Scopus @ Elsevier (DOI): 10.1002/cam4.5777 (DOI: 10.1002/cam4.5777, PubMed: 36912123)
2.	Satoshi Sumida, Mayuko Ichimura-Shimizu, Yuko Miyakami, Takumi Kakimoto, Tomoko Kobayashi, Yasuyo Saijo, Minoru Matsumoto, Hirohisa Ogawa, Takeshi Oya, Yoshimi Bando, Hisanori Uehara, Shu Taira, Mitsuo Shimada and Koichi Tsuneyama : Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 251-259, 2023. (Summary) Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin. J. Med. Invest. 70 : 251-259, February, 2023. (Keyword) Humans / Epidermal Cyst / Spleen / Pancreatic Diseases / Epithelial Cells / Immunohistochemistry (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.251 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164730 ● Search Scopus @ Elsevier (PMID): 37164730 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.251 (DOI: 10.2152/jmi.70.251, PubMed: 37164730)
3.	Souichiro Sasa, Hiroaki Inoue, INUI Tomohiro, Naoki Miyamoto, Mariko Aoyama, Kazumasa Okumura, Hiroaki Toba, Takahiro Yoshida, Tezuka Miki, Hirose Chieko, Yasuyo Saijo, Hisanori Uehara, Izumori Ayumi, Takahashi Masako, Sasa Mitsunori and Hiromitsu Takizawa : Axillary lymphangioma that developed following COVID-19 vaccination: a case report, Surgical Case Reports, Vol.8, No.1, 131, 2022. (Summary) Extensive vaccination programs are being implemented worldwide for coronavirus disease 2019 (COVID-19). With the spread of vaccination, swelling of the lymph nodes after vaccination is frequently seen. We encountered a patient who developed left axillary lymphadenoma following vaccine administration. The patient was a Japanese woman in her 80 s who had previously undergone surgery for right breast cancer. She received two injections of the Pfizer-BioNTech COVID-19 vaccine in her left arm. Approximately 3 months later, she complained of left axillary swelling, and imaging resulted in a diagnosis of left axillary lymphangioma. In accordance with the patient's wishes, we performed axillary mass resection. The pathological diagnosis was lymphangioma. Our examination findings indicated that congestion of the axillary lymph vessels might have been caused by upper-arm injections of the COVID-19 vaccine. (Link to Publication Site) ● Publication site (DOI): 10.1186/s40792-022-01488-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35798903 ● Search Scopus @ Elsevier (PMID): 35798903 ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-022-01488-5 (DOI: 10.1186/s40792-022-01488-5, PubMed: 35798903)

Academic Paper (Unrefereed Paper):

1.	Yosuke Iwakawa, Masaaki Nishi, Yuuma Wada, Kouzou Yoshikawa, Chie Takasu, Mitsuo Shimada, Yasuyo Saijo, Minoru Matsumoto, Takeshi Oya and Hisanori Uehara : Pleomorphic type undifferentiated gastric sarcoma, report of a case., Clinical Journal of Gastroenterology, Vol.16, No.1, 20-25, 2022. (Summary) Reports on pleomorphic type of undifferentiated sarcoma (PUS) originating from the gastrointestinal tract, especially the stomach, are extremely rare. We herein report a case of pleomorphic type undifferentiated gastric sarcoma. The patient was a 67-year-old woman. The chief complaint was upper abdominal pain. Upper gastrointestinal endoscopy, ultrasonography, and contrast-enhanced computed tomography showed two submucosal tumors at the greater curvature of the fundus and the lesser curvature of the gastric angle. Endoscopic ultrasound-guided fine-needle aspiration revealed a c-kit-negative spindle cell tumor at the greater curvature of the fundus. Total gastrectomy, splenectomy, and partial resection of the diaphragm and liver were performed. One lesion had invaded the lateral segment of the liver, left diaphragm and spleen. The postoperative course was uneventful. Histopathological and immunohistochemical examinations of the resected specimen revealed PUS. Peritoneal dissemination was detected at 8 months after surgery. However, no effective therapeutic agents were adopted for chemotherapy. The patient had poor performance status due to disease progression and underwent best supportive care. The patient died 10 months after surgery. This case highlights the imaging, histological diagnosis, and treatment strategy for PUS originating from the stomach. Surgeons should be aware of PUS as a differential diagnosis in cases with submucosal tumor of the stomach. (Keyword) Female / Humans / Aged / Stomach Neoplasms / Gastrectomy / Sarcoma / Endoscopy, Digestive System / Liver Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1007/s12328-022-01729-y (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36289170 ● Search Scopus @ Elsevier (PMID): 36289170 ● Search Scopus @ Elsevier (DOI): 10.1007/s12328-022-01729-y (DOI: 10.1007/s12328-022-01729-y, PubMed: 36289170)

Review, Commentary:

1.	Yoshimi Bando, Tomoko Kobayashi, Yuko Miyakami, Satoshi Sumida, Takumi Kakimoto, Yasuyo Saijo and Hisanori Uehara : Triple-negative breast cancer and basal-like subtype : Pathology and targeted therapy., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 213-219, 2021. (Summary) Triple-negative breast cancer (TNBC) is a heterogenous disease. For personalized medicine, it is essential to identify and classify tumor subtypes to develop effective therapeutic strategies. Although gene expression profiling has identified several TNBC subtypes, classification of these tumors remains complex. Most TNBCs exhibit an aggressive phenotype, but some rare types have a favorable clinical course. In this review, we summarize the classification and characteristics related to the various TNBC subtypes, including the rare types. Therapeutic methods that are suitable for each subtype are also discussed. Of the intrinsic breast cancer subtypes identified by gene expression analysis, the basal-like subtype specifically displayed decreased expression of an estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) cluster. We also present results that characterize the TNBC and basal-like phenotypes. TNBC may be categorized into four major classes : basal-like, immune-enriched, mesenchymal, and luminal androgen receptor. Therapeutic strategies for each subtype have been proposed along with newly approved targeted therapies for TNBC, such as immune checkpoint inhibitors. Understanding the classification of TNBC based on gene expression profiling in association with clinicopathological factors will facilitate accurate pathological diagnosis and effective treatment selection. J. Med. Invest. 68 : 213-219, August, 2021. (Keyword) Gene Expression Profiling / Humans / Receptors, Estrogen / Triple Negative Breast Neoplasms (Tokushima University Institutional Repository) ● Metadata: 116478 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.213 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759133 ● Search Scopus @ Elsevier (PMID): 34759133 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.213 (Tokushima University Institutional Repository: 116478, DOI: 10.2152/jmi.68.213, PubMed: 34759133)

Proceeding of Domestic Conference:

1.	Minoru Matsumoto, Yasuyo Saijo, Mayuko Shimizu, Hirohisa Ogawa, Koichi Tsuneyama, Mitsuru Matsumoto and Takeshi Oya : 胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性, Proceedings of the Japanese Society of Pathology, Vol.111, No.1, 243, Apr. 2022.
2.	Yasuyo Saijo, Yoshimi Bando, Takeshi Oya, Minoru Matsumoto and Hisanori Uehara : S2838 頭蓋内腫瘍, 日本病理学会中国四国支部学術集会第136回スライドカンファレンス, Oct. 2021.
3.	庄野隆志, Seiya Inoue, 南城和正, Yasuyo Saijo, Hidenori Maki, Mariko Aoyama, Takeshi Nishino, Masakazu Goto, Takahiro Yoshida, Hiromitsu Takizawa and Akira Tangoku : 術前化学療法に効果を示し，根治手術を施行した進行食道粘表皮癌の1例, 第75回日本食道学会学術集会(ハイブリッド開催), Sep. 2021.