Tokushima University / Educator and Researcher Directory --- Sato, Ryota

Personal Web Page

https://researchmap.jp/rsato358 (researchmap)

https://orcid.org/0009-0005-6940-9159 (ORCID)

Field of Study

○	Synthetic Organic Chemistry
○	Synthetic Organic Chemistry

Subject of Study

○	複雑天然有機化合物の全合成研究
○	有機化学反応開発 (organocatalysts, radical reaction)

Book / Paper

Academic Paper (Judged Full Paper):

1.	Kimika Kayano, Tomohiro Tsutsumi, Yoshiko Murata, Chie Ogasa, Takehiro Watanabe, Ryota Sato, Sangita Karanjit and Kosuke Namba : Epoxide ring-opening reactions for abundant production of mugineic acids and nicotianamine probes., Angewandte Chemie International Edition, Vol.63, No.20, e202401411, 2024. (Summary) A succinct synthetic approach to mugineic acids and 2'-hydroxynicotianamine was established. Unlike all other synthetic methods, this approach utilized epoxide ring-opening reactions to form two C-N bonds and is characterized by the absence of redox reactions. Mugineic acid was synthesized from three readily available fragments on a gram scale in 6 steps. The protected 2'-hydroxynicotianamine was also synthesized in 4 steps, and the dansyl group, serving as a fluorophore, was introduced through a click reaction after propargylation of the 2'-hydroxy group. The dansyl-labeled nicotianamine (NA) iron complexes were internalized by oocytes overexpressing ZmYS1 (from maize) or PAT1 (from human) transporters, indicating successful transport of the synthesized NA-probe through these transporters. (Keyword) Epoxy Compounds / Humans / Molecular Structure / Azetidinecarboxylic Acid (Tokushima University Institutional Repository) ● Metadata: 119292 (Link to Publication Site) ● Publication site (DOI): 10.1002/anie.202401411 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38500479 ● Search Scopus @ Elsevier (PMID): 38500479 ● Search Scopus @ Elsevier (DOI): 10.1002/anie.202401411 (Tokushima University Institutional Repository: 119292, DOI: 10.1002/anie.202401411, PubMed: 38500479)
2.	Yuna Kondo, Tenta Nakamura, Daisuke Tsuji, Ryota Sato, Sangita Karanjit, Reiko Akagi and Kosuke Namba : Development of 1,3a,6a-triazapentalene derivatives as practical erasable fluorescent cell staining reagents., Tetrahedron Letters, Vol.138, 154986, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.tetlet.2024.154986 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.tetlet.2024.154986 (DOI: 10.1016/j.tetlet.2024.154986)
3.	I Stephen Ting, W Dylan Snelson, R Tucker Huffman, Akihiro Kuroo, Ryota Sato and A Ryan Shenvi : Synthesis of (-)-Cotylenol, a 14-3-3 Molecular Glue Component., Journal of the American Chemical Society, Vol.145, No.37, 20634-20645, 2023. (Summary) Small molecules that modulate the 14-3-3 protein-protein interaction (PPI) network represent valuable therapeutics and tool compounds. However, access has been lost to 14-3-3 PPI molecular glues of the cotylenin class, leading to investigations into the practical chemical syntheses of congeners and analogues. Here we report a concise synthesis of (-)-cotylenol via a 10-step asymmetric entry into a diversifiable 5-8-5 core. This route features a mild Liebeskind-Srogl fragment coupling that tolerates unprecedented steric hindrance to produce a highly congested ketone, and a tandem Claisen-ene cascade that establishes the 8-membered ring. Late-stage control of stereochemistry and functionality leads to (-)-cotylenol and sets the stage for focused library synthesis. (Keyword) Diterpenes / 14-3-3 Proteins / Gene Library / Ketones (Link to Publication Site) ● Publication site (DOI): 10.1021/jacs.3c07849 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37683289 ● Search Scopus @ Elsevier (PMID): 37683289 ● Search Scopus @ Elsevier (DOI): 10.1021/jacs.3c07849 (DOI: 10.1021/jacs.3c07849, PubMed: 37683289)
4.	Ryuichi Sumida, Misa Okuda, Akane Mera, Masaki Inoue, Sangita Karanjit, Kanji Niwa, Tomohiro Tsutsumi, Ryota Sato, Atsushi Nakayama, Naonobu Tanaka, Masataka Oda and Kosuke Namba : A suitable stereoisomer of vibrioferrin probes for iron uptake of Vibrio parahaemolyticus, Chemistry Letters, 2023. (Tokushima University Institutional Repository) ● Metadata: 118228 (Link to Publication Site) ● Publication site (DOI): 10.1246/cl.230166 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1360016863185963264 ● Search Scopus @ Elsevier (DOI): 10.1246/cl.230166 (Tokushima University Institutional Repository: 118228, DOI: 10.1246/cl.230166, CiNii: 1360016863185963264)
5.	Daisuke Tsuji, Atsushi Nakayama, RIko Yamamoto, Shuji Nagano, Takashi Taniguchi, Ryota Sato, Sangita Karanjit, Naoki Muguruma, Tetsuji Takayama, Kohji Itoh and Kosuke Namba : 1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes, Communications Chemistry, Vol.6, No.1, 37, 2023. (Summary) 1,3a,6a-Triazapentalene (TAP) is a compact fluorescent chromophore whose fluorescence properties vary greatly depending on the substituents on the TAP ring. This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Under UV irradiation, 2-p-nitrophenyl-TAP generated reactive oxygen species (ROS) that induced an apoptosis and ferroptosis in cancer cells. Therefore, it was revealed that 2-p-nitrophenyl-TAP is the most compact dye that can generate ROS by photoirradiation. (Tokushima University Institutional Repository) ● Metadata: 118227 (Link to Publication Site) ● Publication site (DOI): 10.1038/s42004-023-00838-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36813913 ● Search Scopus @ Elsevier (PMID): 36813913 ● Search Scopus @ Elsevier (DOI): 10.1038/s42004-023-00838-0 (Tokushima University Institutional Repository: 118227, DOI: 10.1038/s42004-023-00838-0, PubMed: 36813913)
6.	Yuki Kimura, Eisaku Ohashi, Sangita Karanjit, Takashi Taniguchi, Atsushi Nakayama, Hiroshi Imagawa, Ryota Sato and Kosuke Namba : Total synthesis of proposed structures of 4,10-dihydroxy 8,12-guaianolides, Organic Letters, Vol.24, No.17, 3297-3301, 2022. (Summary) The first total syntheses of two 4,10-dihydroxy-8,12-guaianolides that were reported to be natural products were achieved. Toward the syntheses of a collection of related guaianolides, the typical 5,7-fused system of 8,12-guaianolides was constructed by a ring expansion reaction of a hydroxylated coronafacic acid analogue that can be practically synthesized and optically resolved. The total syntheses of these compounds revealed that the previously reported structures of both natural products were incorrect. (Keyword) Biological Products / Molecular Structure (Tokushima University Institutional Repository) ● Metadata: 117329 (Link to Publication Site) ● Publication site (DOI): 10.1021/acs.orglett.2c01215 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35446586 ● Search Scopus @ Elsevier (PMID): 35446586 ● Search Scopus @ Elsevier (DOI): 10.1021/acs.orglett.2c01215 (Tokushima University Institutional Repository: 117329, DOI: 10.1021/acs.orglett.2c01215, PubMed: 35446586)

Proceeding of Domestic Conference:

1.	MARUO Takaya, 三原泰輝, Ryota Sato, Atsushi Nakayama and Kosuke Namba : KB343の全合成研究, 日本薬学会第144年会, Mar. 2024.
2.	KONDOH Yuna, NAKAMURA Tenta, Riko Yamamoto, Ryota Sato, Sangita Karanjit, Daisuke Tsuji, 赤木玲子 and Kosuke Namba : 長波長領域で活性化する1,3a,6a-トリアザペンタレン(TAP)類の合成と光応答型細胞毒性の評価, 日本薬学会第144年会, Mar. 2024.
3.	Ryuichi Sumida, INOUE Masaki, Ryota Kotaka, Ryota Sato, Atsushi Nakayama, Sangita Karanjit and Kosuke Namba : Calyciphylline F の全合成, 日本薬学会第144年会, Mar. 2024.
4.	YUKI Kimura, Eisaku Ohhashi, Sangita Karanjit, Ryota Sato and Kosuke Namba : Palau'amineの第3世代合成研究, 日本薬学会第144年会, Mar. 2024.
5.	HAGIMOTO Daichi, Ryota Sato, Sangita Karanjit and Kosuke Namba : Alstonisine の全合成研究, 日本薬学会第144年会, Mar. 2024.
6.	Takashi Taniguchi, YUKI Kimura, Ryota Sato, Sangita Karanjit and Kosuke Namba : Guianolide型セスキテルペンラクトン類の第二世代合成研究, 日本薬学会第144年会, Mar. 2024.
7.	MAJIMA Rei, KOHDAI Kawata, Ryota Sato, Sangita Karanjit and Kosuke Namba : Scabronine Gの全合成研究, 日本薬学会第144年会, Mar. 2024.
8.	Jun Hashimura, Shuji Nagano, Ryota Sato, Sangita Karanjit and Kosuke Namba : Eleganine Aの合成研究, 日本薬学会第144年会, Mar. 2024.
9.	Sangita Karanjit, Tanaka Emiko, MAJIMA Rei, Ryota Sato and Kosuke Namba : Catalytic carboxylation and decarboxylation approach for the construction of bicyclic intermediates as core structural motifs in natural products, 日本化学会第104回春季年会, Mar. 2024.
10.	KONDOH Yuna, NAKAMURA Tenta, Riko Yamamoto, Ryota Sato, Sangita Karanjit, Daisuke Tsuji, 赤木玲子 and Kosuke Namba : 長波長領域で活性化する1,3a,6a-トリアザペンタレン(TAP)類の合成と光応答型細胞毒性の評価, 日本プロセス化学会東四国地区フォーラムセミナー, Jan. 2024.
11.	Ryuichi Sumida, INOUE Masaki, Ryota Kotaka, Ryota Sato, Atsushi Nakayama, Sangita Karanjit and Kosuke Namba : Calyciphylline F の全合成研究, 第34回日本プロセス化学会東四国地区フォーラムセミナー, Jan. 2024.
12.	Takashi Taniguchi, YUKI Kimura, Ryota Sato, Sangita Karanjit and Kosuke Namba : Guianolide型セスキテルペンラクトン類の第二世代合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
13.	MARUO Takaya, 三原泰輝, Ryota Sato, Atsushi Nakayama and Kosuke Namba : KB343の全合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
14.	TANI Ayane, Ryota Sato and Kosuke Namba : NHC触媒とシンナムアルデヒド誘導体を用いたラジカル環化反応の開発, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
15.	KONDOH Yuna, NAKAMURA Tenta, Riko Yamamoto, Sangita Karanjit, Ryota Sato, Daisuke Tsuji and Kosuke Namba : 赤色光応答型1,3a,6a-トリアザペンタレン(TAP)類の開発と光細胞毒性の評価, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
16.	YUKI Kimura, Eisaku Ohhashi, Sangita Karanjit, Ryota Sato and Kosuke Namba : Palau'amineの第3世代合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
17.	Jun Hashimura, Shuji Nagano, Ryota Sato, Sangita Karanjit and Kosuke Namba : Eleganine Aの合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
18.	MAJIMA Rei, KOHDAI Kawata, Ryota Sato, Sangita Karanjit and Kosuke Namba : Scabronine Gの全合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
19.	KOHDAI Kawata, Ryuji Okamoto, Kohki Katoh, Sangita Karanjit, Ryota Sato and Kosuke Namba : Nagelamide Q の全合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
20.	Ryuichi Sumida, INOUE Masaki, Ryota Kotaka, Ryota Sato, Atsushi Nakayama, Sangita Karanjit and Kosuke Namba : Calyciphylline F の全合成研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.
21.	Ryota Sato, Huffman R. Tucker, 黒尾明弘 and Shenvi A. Ryan : (-)-コチレノールの全合成, 第65回天然有機化合物討論会, Sep. 2023.
22.	KOHDAI Kawata, 岡本龍治, Kohki Katoh, Sangita Karanjit, Ryota Sato and Kosuke Namba : Nagelamide Q の全合成研究, 第65回天然物有機化合物討論会, Sep. 2023.
23.	Ryota Sato : コロナ禍のアメリカポスドク体験, 第37回若手研究者のための化学道場, Sep. 2023.
24.	Takashi Taniguchi, YUKI Kimura, Ryota Sato, Sangita Karanjit and Kosuke Namba : Guianolide型セスキテルペンラクトン類の第二世代合成研究, 第37回若手化学者のための化学道場, Sep. 2023.
25.	Ryuichi Sumida, INOUE Masaki, Ryota Kotaka, Ryota Sato, Atsushi Nakayama, Sangita Karanjit and Kosuke Namba : Calyciphylline F の全合成研究, 第37回若手化学者のための化学道場, Sep. 2023.
26.	Jun Hashimura, Shuji Nagano, Ryota Sato, Sangita Karanjit and Kosuke Namba : Eleganine Aの合成研究, 第37回若手化学者のための化学道場, Sep. 2023.
27.	YUKI Kimura, Eisaku Ohhashi, Sangita Karanjit, Ryota Sato and Kosuke Namba : Palau'amineの第3世代合成研究, 日本薬学会第143年会, Mar. 2023.
28.	Ryuichi Sumida, Masaki Inoue, Ryota Kotaka, Ryota Sato, Atsushi Nakayama and Kosuke Namba : Calyciphylline Fの全合成研究, 日本薬学会第143年会, Mar. 2023.
29.	Kimika Kayano, Tomohiro Tsutsumi, Sangita Karanjit, Ryota Sato and Kosuke Namba : ムギネ酸類の効率的全合成, 日本薬学会第143年会, Mar. 2023.
30.	Kohdai Kawata, Ryuji Okamoto, Kohki Katoh, Ryota Sato, Atsushi Nakayama and Kosuke Namba : Nagelamide Qの全合成研究, 日本薬学会第143年会, Mar. 2023.
31.	Miho Yamaguchi, Saki Funabiki, 小笠千恵, Ryota Sato, 村田佳子, 鈴木基史 and Kosuke Namba : ムギネ酸の構造簡略化体の開発研究, 日本薬学会第143年会, Mar. 2023.
32.	Ten Katoh, Tenta Nakamura, Sangita Karanjit, Ryota Sato and Kosuke Namba : アブシジン酸の全合成と蛍光プローブへの展開, 日本薬学会第143年会, Mar. 2023.
33.	Ryota Sato, Huffman R. Tucker, 黒尾明弘 and Shenvi A. Ryan : (-)-コチレノールの全合成, 日本薬学会第143年会, Mar. 2023.
34.	Yuki Kimura, Eisaku Ohhashi, Sangita Karanjit, Ryota Sato and Kosuke Namba : Palau'amineの第3世代合成研究, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中四国支部学術大会, Nov. 2022.
35.	Kimika Kayano, Tomohiro Tsutsumi, 小笠千恵, 村田佳子, Sangita Karanjit, Ryota Sato and Kosuke Namba : 哺乳類の鉄輸送機構解明に向けたニコチアナミンプローブの効率的合成, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
36.	Kohdai Kawata, Ryuji Okamoto, Kohki Katoh, Ryota Sato, Atsushi Nakayama and Kosuke Namba : Nagelamide Qの全合成研究, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
37.	Takashi Taniguchi, Yuki Kimura, Ryota Sato, Sangita Karanjit and Kosuke Namba : Guaianolide型セスキテルペンラクトン類の第二世代合成, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
38.	Miho Yamaguchi, Saki Funabiki, 小笠千恵, Ryota Sato, 村田佳子, 鈴木基史 and Kosuke Namba : ムギネ酸の構造簡略化体の開発研究, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
39.	Ten Katoh, Tenta Nakamura, Sangita Karanjit, Ryota Sato and Kosuke Namba : アブシジン酸の全合成と蛍光プローブへの展開, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
40.	Jun Hashimura, Shuji Nagano, Sangita Karanjit, Ryota Sato and Kosuke Namba : Eleganine Aの全合成研究, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
41.	Kohtaroh Ohoka, Takumi Ishizuka, Ryota Sato, Kazuki Ushiyama, 須藤宏城, Ryota Sato, Atsushi Nakayama, 谷野圭持 and Kosuke Namba : (+)-Lapidilectine Bの合成研究, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022.
42.	Kimika Kayano, Tomohiro Tsutsumi, 小笠千恵, 村田佳子, Sangita Karanjit, Ryota Sato and Kosuke Namba : 哺乳類の鉄輸送機構解明に向けたニコチアナミンプローブの効率的合成, 第36回若手化学者のための化学道場, Sep. 2022.
43.	Kohdai Kawata, Ryuji Okamoto, Kohki Katoh, Ryota Sato, Atsushi Nakayama and Kosuke Namba : Nagelamide Qの全合成研究, 第36回若手化学者のための化学道場, Sep. 2022.
44.	Yuki Kimura, Eisaku Ohhashi, Sangita Karanjit, Takashi Taniguchi, Atsushi Nakayama, 今川洋, Ryota Sato and Kosuke Namba : Guaianolide型セスキテルペンラクトン類の全合成, 第64回天然有機化合物討論会, Sep. 2022.
45.	Monyue Chiyu, Tomohiro Tsutsumi, Ryota Sato, Atsushi Nakayama and Kosuke Namba : 新規不斉DMAP触媒の合成研究, 日本薬学会第142年会, Mar. 2022.
46.	Kohtaroh Ohoka, Takumi Ishizuka, Kazuki Ushiyama, Yudai Ishikawa, 須藤宏城, Ryota Sato, Atsushi Nakayama, 谷野圭持 and Kosuke Namba : (+)-Lapidilectine Bの形式全合成, 日本薬学会第142年会, Mar. 2022.
47.	Kohtaroh Ohoka, Takumi Ishizuka, Ryota Sato, Kazuki Ushiyama, Yudai Ishikawa, 須藤宏城, Atsushi Nakayama, 谷野圭持 and Kosuke Namba : (+)-Lapidilectine Bの合成研究, 第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2021.
48.	Monyue Chiyu, Tomohiro Tsutsumi, Ryota Sato, Atsushi Nakayama and Kosuke Namba : 新規不斉DMAP触媒の合成研究, 第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2021.
49.	Masaki Inoue, Ryota Sato, Ryota Kotaka, Atsushi Nakayama, Sangita Karanjit, 谷野圭持 and Kosuke Namba : Calyciphylline Fの全合成研究, 第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2021.
50.	Masaki Inoue, Ryota Sato, Ryota Kotaka, Ryuichi Fuchigami, Atsushi Nakayama, Sangita Karanjit and Kosuke Namba : Calyciphylline Fの全合成研究, 創薬懇話会2021, Jun. 2021.

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Assistant Professor : Sato, Ryota

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)