徳島大学 / 教育研究者総覧 --- ウラアナイツト

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徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 先端基礎栄養学教育研究プロジェクト ⟩
徳島大学 ⟩ 大学院医歯薬学研究部 ⟩ 医学域 ⟩ 栄養科学部門 ⟩ 医科栄養学系 ⟩ 生体栄養学 ⟩

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研究活動

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研究テーマ

著書・論文

学術論文(審査論文):

1.	Takayuki Uchida, Kohno Madoka, Chinami Itoh, Erika Yamano, Hiroki Matsuki, MIZANUR MD Rahman, ANAYT ULLA, Minori Suzuki, Takahiro Ishiguro and Takeshi Nikawa : Inhibitory Effect of Kori-tofu Protein on Denervation-Induced Atrogene Expression in Mouse Skeletal Muscle, Biological Sciences in Space, Vol.38, 1-7, 2024.
2.	ANAYT ULLA, Kanae Osaki, Mizanur Md Rahman, Reiko Nakao, Takayuki Uchida, Isafumi Maru, Kazuaki Mawatari, Tomoya Fukawa, Hiro-omi Kanayama, Iori Sakakibara, Katsuya Hirasaka and Takeshi Nikawa : Morin improves dexamethasone-induced muscle atrophy by modulating atrophy-related genes and oxidative stress in female mice., Bioscience, Biotechnology, and Biochemistry, Vol.86, No.10, 1448-1458, 2022. (要約) This study investigated the effect of morin, a flavonoid, on dexamethasone-induced muscle atrophy in C57BL/6J female mice. Dexamethasone (10 mg/kg body weight) for 10 days significantly reduced body weight, gastrocnemius and tibialis anterior muscle mass, and muscle protein in mice. Dexamethasone significantly upregulated muscle atrophy-associated ubiquitin ligases, including atrogin-1 and MuRF-1, and the upstream transcription factors FoxO3a and Klf15. Additionally, dexamethasone significantly induced the expression of oxidative stress-sensitive ubiquitin ligase Cbl-b and the accumulation of the oxidative stress markers malondialdehyde and advanced protein oxidation products in both the plasma and skeletal muscle samples. Intriguingly, morin treatment (20 mg/kg body weight) for 17 days effectively attenuated the loss of muscle mass and muscle protein and suppressed the expression of ubiquitin ligases while reducing the expression of upstream transcriptional factors. Therefore, morin might act as a potential therapeutic agent to attenuate muscle atrophy by modulating atrophy-inducing genes and preventing oxidative stress. (キーワード) Animals / Body Weight / Dexamethasone / Female / Flavones / Malondialdehyde / Mice / Mice, Inbred C57BL / Muscle Proteins / Muscle, Skeletal / Muscular Atrophy / Oxidative Stress / Tripartite Motif Proteins / Ubiquitin-Protein Ligases (出版サイトへのリンク) ● Publication site (DOI): 10.1093/bbb/zbac140 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35977398 ● Search Scopus @ Elsevier (PMID): 35977398 ● Search Scopus @ Elsevier (DOI): 10.1093/bbb/zbac140 (DOI: 10.1093/bbb/zbac140, PubMed: 35977398)
3.	Madoka Kohno, ANAYT ULLA, Rina Taniguchi, Akane Ohishi, Kako Hirayama, Yuma Takemura, Shoichiro Takao, Yuki Kanazawa, Yuki Matsumoto, Masafumi Harada, Tomoya Fukawa, Hiro-omi Kanayama, Takayuki Uchida, Toshio Suzuki and Takeshi Nikawa : Daily Dietary Supplementation with Steamed Soybean Improves Muscle Volume and Strength in Healthy People Lacking Exercise., Journal of Nutritional Science and Vitaminology, Vol.68, No.6, 521-526, 2022. (要約) Various dietary protein supplements are used by the elderly and bedridden to maintain their skeletal muscle mass and functions. High-quality proteins act as an anabolic driver and help to improve muscle strength and performance. Previously, we reported that soy protein significantly attenuates denervation-induced loss of muscle mass and myofiber cross sectional area in mice with inhibition of ubiquitination and degradation of IRS-1 in tibialis anterior muscle. It also increased muscle volume and strength in bedridden patients. In the present study, we investigated the effects of dietary soybean supplementation on muscle functions in taxi drivers lacking vigorous physical exercise. We conducted a case-control study on 25 healthy, male taxi drivers between the ages of 36 and 71 y performing minimal physical exercise. They were divided into two dietary groups: the soybean diet group (n=13) who ate daily meals (dinner) supplemented with 50 g of steamed soybean for 30 d and the control diet group (n=12) who received no soybean supplement. Next, we measured the muscle cross-sectional area (CSA) and muscle strength and function in both the groups before and after 30 d of soybean intake. The body weights of both diet groups did not differ significantly over time. However, after 30 d of soybean supplementation, the soybean-fed group developed significantly higher muscle CSA and grip strength compared to the control groups. In conclusion, dietary soybean supplementation improved muscle function in taxi drivers who lacked exercise. (キーワード) Male / Animals / Mice / Soybeans / Case-Control Studies / Muscle, Skeletal / Dietary Supplements / Muscle Strength / Dietary Proteins (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.68.521 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36596550 ● Search Scopus @ Elsevier (PMID): 36596550 ● Search Scopus @ Elsevier (DOI): 10.3177/jnsv.68.521 (DOI: 10.3177/jnsv.68.521, PubMed: 36596550)

総説・解説:

1.	Takeshi Nikawa, ANAYT ULLA and Iori Sakakibara : Polyphenols and Their Effects on Muscle Atrophy and Muscle Health, Molecules, Vol.26, No.16, 4887, Aug. 2021. (要約) Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies. (キーワード) Animals / Anti-Inflammatory Agents / Antioxidants / Humans / Muscle, Skeletal / Muscular Atrophy / Phytochemicals / Polyphenols / Signal Transduction (徳島大学機関リポジトリ) ● Metadata: 117355 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/molecules26164887 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34443483 ● Search Scopus @ Elsevier (PMID): 34443483 ● Search Scopus @ Elsevier (DOI): 10.3390/molecules26164887 (徳島大学機関リポジトリ: 117355, DOI: 10.3390/molecules26164887, PubMed: 34443483)

国内講演発表:

1.	伊藤千菜美, 鈴木穂, 松木大揮, ウラアナイツト, 内田貴之, 中森俊宏, 松井利郎, 二川健 : 大豆タンパク質の抗筋萎縮活性, 第56回日本栄養・食糧学会中国・四国支部大会, 2023年10月.
2.	ANAYT ULLA, Mizanur Md Rahman, Takayuki Uchida, Hiroyuki Kayaki, Yosuke Nishitani, Susumu Yoshino, Hiroshige Kuwahara and Takeshi Nikawa : 3-(4-hydroxy-3-methoxyphenyl) propionic acid attenuates dexamethasone-induced muscle atrophy by suppressing Atrogin-1 and MuRF-1, 日本食品科学工学会第70回記念大会, Aug. 2023.
3.	伊藤千菜美, 松木大揮, 鈴木穂, 鴻野まどか, ウラアナイツト, 内田貴之, 石黒貴寛, 二川健 : 高野豆腐タンパク質の抗筋萎縮活性の解析, 第77回日本栄養・食糧学会大会, 2023年5月.
4.	津田晴香, 内田貴之, 川端いずみ, ウラアナイツト, 谷口瑠菜, 二川健 : 筋肉へのピセアタンノール作用の検討, 第77回日本栄養・食糧学会大会, 2023年5月.
5.	松木大揮, 鈴木穂, 鴻野まどか, ウラアナイツト, 馬渡一諭, 髙橋章, 宮脇克行, 渡辺崇人, 三戸太郎, 栗木隆吉, 二川健 : コオロギの抗筋萎縮作用について, 第77回日本栄養・食糧学会大会, 2023年5月.
6.	山野恵理華, 伊藤千菜美, 松木大揮, 鴻野まどか, ウラアナイツト, 内田貴之, 上番増喬, 高木均, 二川健 : セルロースナノファイバーの栄養学的機能性の検討, 第77回日本栄養・食糧学会大会, 2023年5月.