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徳島大学先端酵素学研究所重点研究部門 (researchmapへのインポート用ファイル) [PDF解説] [researchmapへの自動反映について]

研究活動

専門分野

神経科学 (Neuroscience)

研究テーマ

アルツハイマー発症機序の改名と進行抑制 (シナプス (synapse), 神経細胞 (neuron), アストロサイト (astrocyte), 認知症 (dementia), 細胞間接着)

著書・論文

学術論文(審査論文):

1. Takeshi Kameyama, Muneaki Miyata, Hajime Shiotani, Jun Adachi, Soichiro Kakuta, Yasuo Uchiyama, Kiyohito Mizutani and Yoshimi Takai :
Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain.,
iScience, Vol.26, No.10, 2023.
(DOI: 10.1016/j.isci.2023.108010,   PubMed: 37829206)
2. Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani and Yoshimi Takai :
Necl2/3-mediated mechanism for tripartite synapse formation.,
Development, Vol.150, No.4, 2023.
(DOI: 10.1242/dev.200931,   PubMed: 36458527)
3. Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Kenji Mandai, Miwako Yamasaki, Masahiko Watanabe, Kiyohito Mizutani and Yoshimi Takai :
Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula.,
The Journal of Comparative Neurology, Vol.529, No.2, 450-477, 2020.
(DOI: 10.1002/cne.24958,   PubMed: 32452538)
4. Hajime Shiotani, Muneaki Miyata, Kiyohito Mizutani, Shujie Wang, Akira Mizoguchi, Hideki Mochizuki, Kenji Mandai and Yoshimi Takai :
Interaction of nectin-2α with the auxiliary protein of the voltage-gated A-type K+ channel Kv4.2 dipeptidyl aminopeptidase-like protein at the boundary between the adjacent somata of clustered cholinergic neurons in the medial habenula,
Molecular and Cellular Neuroscience, Vol.94, 32-40, 2018.
(DOI: 10.1016/j.mcn.2018.11.001,   PubMed: 30408526)
5. Hajime Shiotani, Muneaki Miyata, Yu Itoh, Shujie Wang, Aika Kaito, Akira Mizoguchi, Miwako Yamasaki, Masahiko Watanabe, Kenji Mandai, Hideki Mochizuki and Yoshimi Takai :
Localization of nectin-2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the subcellular localization of the voltage-gated A-type K+ channel Kv4.2 in the medial habenula,
The Journal of Comparative Neurology, Vol.526, No.9, 1527-1549, 2018.
(DOI: 10.1002/cne.24425,   PubMed: 29524214)
6. Hajime Shiotani, Tomohiko Maruo, Shotaro Sakakibara, Muneaki Miyata, Kenji Mandai, Hideki Mochizuki and Yoshimi Takai :
Aging-dependent expression of synapse-related proteins in the mouse brain.,
Genes to Cells, Vol.22, No.5, 472-484, 2017.
(DOI: 10.1111/gtc.12489,   PubMed: 28397972,   Elsevier: Scopus)
7. Muneaki Miyata, Kenji Mandai, Tomohiko Maruo, Junya Sato, Hajime Shiotani, Aika Kaito, Yu Itoh, Shujie Wang, Takeshi Fujiwara, Akira Mizoguchi, Yoshimi Takai and Yoshiyuki Rikitake :
Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain.,
Brain Research, Vol.1649, No.Pt A, 90-101, 2016.
(DOI: 10.1016/j.brainres.2016.08.023,   PubMed: 27545667)
8. Toru Maeda, Yuki Nakamura, Hajime Shiotani, K Masaru Hojo, Taishi Yoshii, Takanori Ida, Takahiro Sato, Morikatsu Yoshida, Mikiya Miyazato, Masayasu Kojima and Mamiko Ozaki :
Suppressive effects of dRYamides on feeding behavior of the blowfly, Phormia regina.,
Zoological Letters, Vol.1, No.35, 2015.
(DOI: 10.1186/s40851-015-0034-z,   PubMed: 26649188)
9. Takanori Ida, Tomoko Takahashi, Hatsumi Tominaga, Takahiro Sato, Hiroko Sano, Kazuhiko Kume, Mamiko Ozaki, Tetsutaro Hiraguchi, Hajime Shiotani, Saki Terajima, Yuki Nakamura, Kenji Mori, Morikatsu Yoshida, Johji Kato, Noboru Murakami, Mikiya Miyazato, Kenji Kangawa and Masayasu Kojima :
Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors.,
Frontiers in Endocrinology, Vol.3, No.177, 2012.
(DOI: 10.3389/fendo.2012.00177,   PubMed: 23293632)
10. Takanori Ida, Tomoko Takahashi, Hatsumi Tominaga, Takahiro Sato, Kazuhiko Kume, Mamiko Ozaki, Tetsutaro Hiraguchi, Toru Maeda, Hajime Shiotani, Saki Terajima, Hiroko Sano, Kenji Mori, Morikatsu Yoshida, Mikiya Miyazato, Johji Kato, Noboru Murakami, Kenji Kangawa and Masayasu Kojima :
Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila.,
Biochemical and Biophysical Research Communications, Vol.410, No.4, 872-877, 2011.
(DOI: 10.1016/j.bbrc.2011.06.081,   PubMed: 21704020)

総説・解説:

1. Kiyohito Mizutani, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama and Yoshimi Takai :
Nectin-2 in general and in the brain.,
Molecular and Cellular Biochemistry, Vol.477, No.1, 167-180, Oct. 2021.
(DOI: 10.1007/s11010-021-04241-y,   PubMed: 34633611)
2. Kiyohito Mizutani, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama and Yoshimi Takai :
Nectins and Nectin-like molecules in synapse formation and involvement in neurological diseases.,
Molecular and Cellular Neuroscience, Vol.115, Jul. 2021.
(DOI: 10.1016/j.mcn.2021.103653,   PubMed: 34242750)