Tokushima University / Educator and Researcher Directory --- Saijo, Saki

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Book / Paper

Academic Paper (Judged Full Paper):

1.	Takuya Takashima, Momoyo Azuma, M Sato, 森脇好乃美, Saki Saijo, Natsuki Bando, Hiroki Sato, Yuki Nakano, Toshiyuki Nunomura, Manabu Ishihara, Yoshitoyo Ueno, Taiga Itagaki and Jun Oto : Successful treatment of Trichosporon asahii fungemia with isavuconazole in a patient with prominent renal dysfunction and intestinal absorption disorder., Kansenshōgaku Zasshi, 99, 5, 352-356, 2025.
2.	Hiroki Sato, Saki Saijo, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, Konomi Moriwaki, Kazuki Momota, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Taiga Itagaki and Jun Oto : Successful treatment for collagen vascular disease-related respiratory failure with inhaled nitric oxide as a bridging therapy: A case report, Journal of Medical Investigation, 73, 1.2, 270-273, 2025. (Summary) Inhaled nitric oxide (iNO) is approved in Japan for perioperative pulmonary hypertension and persistent pulmonary hypertension in newborns;however, its role in non-cardiac respiratory failure is unclear. A 47-year-old woman with Sjögren's syndrome developed severe acute type I respiratory failure due to collagen vascular disease. Despite high-FIO2 ventilation, her PaO2/FIO2 ratio remained <80, and extracorporeal membrane oxygenation (ECMO) was considered. Administration of iNO at 10 ppm improved oxygenation, with a rapid increase in PaO2/FIO2 ratio. This response allowed time for steroid pulse therapy, rituximab, plasma exchange, and pleural drainage, which stabilized the patient's condition without ECMO. Notably, the temporal association between iNO initiation and rapid oxygenation improvement suggests that pulmonary vascular dysfunction was a major contributor to hypoxemia. Subsequent stabilization with immunosuppressive therapy highlights the role of iNO as a bridging therapy rather than a definitive treatment. In this case, iNO may have served as a bridging therapy, improving oxygenation until immunosuppressive treatment was effective. iNO may serve as a useful interim measure for avoiding ECMO in collagen vascular disease-associated respiratory failure, particularly when pulmonary hypertension is suspected. J. Med. Invest. 73 : 270-273, February, 2026. (Keyword) case report / collagen vascular disease / inhaled nitric oxide / respiratory failure (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.73.270 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 42021089 ● Summary page in Scopus @ Elsevier: 2-s2.0-105036608181 (DOI: 10.2152/jmi.73.270, PubMed: 42021089, Elsevier: Scopus)
3.	Takuya Takashima, Marina Okubo, Shotaro Otani, Masaki Terazawa, Konomi Moriwaki, Saki Saijo, Natsuki Bando, Kazuki Momota, Hiroki Sato, Yuki Nakano, Toshiyuki Nunomura, Manabu Ishihara, Yoshitoyo Ueno, Taiga Itagaki and Jun Oto : Effect of positive-pressure ventilation before extubation on respiratory function: physiological evaluation under simulated extubation, The Journal of Medical Investigation : JMI, 72, 3, 361-366, 2025. (Summary) Positive-pressure ventilation (PPV) before extubation may improve oxygenation and reduce complications after extubation. However, no study has quantitatively evaluated the effects of extubation on breathing and lung volume. A crossover randomized study was performed on 16 patients who received mechanical ventilation and planned to undergo extubation in the intensive-care unit. We used the automatic tube compensation (ATC) mode to simulate extubation. We used electrical impedance tomography and an esophageal balloon catheter to evaluate the work of breathing and lung volume after simulated extubation. We compared the work of breathing and lung volume with and without PPV before simulated extubation. There were no differences in the changes in end-expiratory lung impedance (-7.4 [-18.2-2.3] vs. -11.2 [-16.6-1.1] arbitrary units, p=0.53), anterior-to-posterior ventilation ratio (0.60 [0.49-0.74] vs. 0.60 [0.52-0.79], p=0.75), esophageal pressure swing (4.9 [2.1-8.7] vs. 5.4 [1.9-6.6] cmH2O, p=0.61), dynamic transpulmonary pressure (7.2 [6.7-9.9] vs. 7.6 [6.6-9.7] cmH2O, p=0.93), and pressure time product (2.4 [1.4-4.2] vs. 3.1 [1.0-4.3] cmH2O*s, p=0.84) with and without PPV before simulated extubation. PPV before extubation did not affect breathing work or lung volume after extubation. Therefore, it may delay extubation and increase patient stress. J. Med. Invest. 72 : 361-366, August, 2025. (Keyword) electrical impedance tomography / extubation / intensive care unit / spontaneous breathing test / transpulmonary pressure (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.72.361 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41183938 ● Summary page in Scopus @ Elsevier: 2-s2.0-105020772526 (DOI: 10.2152/jmi.72.361, PubMed: 41183938, Elsevier: Scopus)
4.	Yuki Nakano, Shotaro Otani, Masaki Terazawa, Konomi Moriwaki, Saki Saijo, Natsuki Bando, Kazuki Momota, Hiroki Sato, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Yoshitoyo Ueno, Taiga Itagaki and Jun Oto : Rebound hyperammonemia triggered by interruption of renal replacement therapy in adolescent ornithine transcarbamylase deficiency, Journal of Medical Investigation, 72, 3, 443-446, 2025. (Summary) Ornithine transcarbamylase (OTC) deficiency is the most common urea cycle disorder (UCD) and may lead to life-threatening hyperammonemia. Refractory cases require prompt and aggressive treatment, including renal replacement therapy (RRT), to prevent irreversible neurological damage. We encountered a 14-year-old girl with OTC deficiency who presented with severe hyperammonemia (649 µg/dL;382 µmol/L). Pharmacological therapy and emergency intermittent hemodialysis (IHD) were followed by continuous hemodiafiltration (CHDF), resulting in rapid ammonia clearance. However, a 4-h interruption of CHDF due to catheter replacement led to rebound hyperammonemia (>500 µg/dL;>294 µmol/L), requiring resumption of RRT on day 4. OTC deficiency was subsequently diagnosed based on plasma amino acid and urine organic acid analyses on day 12. After intensifying the pharmacological therapy and achieving stable ammonia levels, RRT was discontinued on day 17. The patient recovered without apparent neurological sequelae and was discharged from the intensive-care unit. This case highlights the importance of uninterrupted RRT in managing acute hyperammonemia and suggests that even short pauses in CHDF can provoke clinically significant rebound. Early initiation of RRT, continuous monitoring of ammonia levels, and individualized treatment strategies are critical for optimizing patient outcomes. J. Med. Invest. 72 : 443-446, August, 2025. (Keyword) ornithine transcarbamylase deficiency / rebound hyperammonemia / renal replacement therapy (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.72.443 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41183952 ● Summary page in Scopus @ Elsevier: 2-s2.0-105020774912 (DOI: 10.2152/jmi.72.443, PubMed: 41183952, Elsevier: Scopus)

Proceeding of Domestic Conference:

1.	Takuya Takashima, Taiga Itagaki, Shotaro Otani, Yusuke Akimoto, Masaki Terazawa, Saki Saijo, Hiroki Sato, Kazuki Momota, Toshiyuki Nunomura and Jun Oto : 経横隔膜圧を指標に吸気圧を調整した人工呼吸器離脱困難の一症例．, Mar. 2026.
2.	Saki Saijo, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, 森脇好乃美, Kazuki Momota, Hiroki Sato, Takuya Takashima, Toshiyuki Nunomura and Jun Oto : 急性心筋梗塞後の重症僧帽弁閉鎖不全に対し ECMO 戦略と MitraClip で救命し得た一例．, Mar. 2026.
3.	Kota Miyoshi, Manabu Ishihara, Masaki Terazawa, Shotaro Otani, 森脇好乃美, Saki Saijo, Kazuki Momota, Hiroki Sato, Takuya Takashima and Jun Oto : 重症脳卒中に対する血管内冷却システムの体温調節能に関する検討．, Mar. 2026.
4.	Shotaro Otani, Kota Miyoshi, Masaki Terazawa, 森脇好乃美, Saki Saijo, Kazuki Momota, Hiroki Sato, Toshiyuki Nunomura, Takuya Takashima and Jun Oto : 低用量リスペリドン投与後に悪性症候群を発症した集中治療患者の一例．, Mar. 2026.
5.	Masaki Terazawa, Kota Miyoshi, Shotaro Otani, Saki Saijo, 森脇好乃美, Kazuki Momota, Hiroki Sato, Takuya Takashima, Toshiyuki Nunomura and Jun Oto : 劇症型心筋炎にメンデルソン症候群を合併し段階的 ECMO 戦略と IMPELLA 併用で救命し得た一例．, Mar. 2026.
6.	Hiroki Sato, Emiko Nakataki, 堀祥昌, 小路美咲, 宮本綾香, Saki Saijo, Toshiyuki Nunomura, Taiga Itagaki and Jun Oto : 心肺停止蘇生後患者における NSE 測定の運用実態と今後の課題．, Mar. 2026.
7.	Yuki Nakano, Shotaro Otani, Masaki Terazawa, 森脇好乃美, Saki Saijo, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Taiga Itagaki and Jun Oto : 前縦隔腫瘍による気道緊急に対して VV-ECMO と化学療法を併用し救命した妊婦症例．, Mar. 2026.
8.	Takuya Takashima, 大久保まりな, Saki Saijo, Natsuki Bando, Kazuki Momota, Hiroki Sato, Toshiyuki Nunomura, Manabu Ishihara and Jun Oto : 【集中治療甲子園】抜管前の陽圧換気が呼吸機能に与える影響の生理学的評価．, Mar. 2026.
9.	Saki Saijo, 野田真由, Yuta Arai, Tomonori Iwasaki and Jun Oto : 肺動脈絞扼術後に生じた気道狭窄をcomputational fluid dynamics (CFD) で解析した一例．, Jan. 2026.
10.	Saki Saijo : シンポジスト「シンポジウム:DICにおける治療介入，薬剤選択のポイント(症例をもとに)」, Nov. 2025.
11.	Takuya Takashima, Saki Saijo, Kazuki Momota, Hiroki Sato, Toshiyuki Nunomura, Manabu Ishihara, Yoshitoyo Ueno and Jun Oto : CRRTでの透析導入にも関わらず不均衡症候群により重篤な意識障害を呈した1例．, Oct. 2025.
12.	Takuya Takashima, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, 森脇好乃美, Saki Saijo, Kazuki Momota, Hiroki Sato, Toshiyuki Nunomura and Jun Oto : ACTH療法中に縦隔膿瘍と頚椎硬膜外膿瘍を発症し速やかに外科的介入を行えた1例．, Jul. 2025.
13.	Saki Saijo : 講師「ハンズオンセミナー2:PICC挿入」, Jul. 2025.
14.	Kazuki Momota, 森脇好乃美, Hiroki Sato, Saki Saijo, Takuya Takashima, Toshiyuki Nunomura, Yoshitoyo Ueno, Taiga Itagaki and Jun Oto : 転倒を契機に出血性ショックを呈したEhlers-Danlos syndrome の一例．, Jul. 2025.
15.	Hiroki Sato, Emiko Nakataki, 堀祥昌, 小路美咲, 宮本綾香, Saki Saijo, Toshiyuki Nunomura, Taiga Itagaki and Jun Oto : 壊死性肺炎と鑑別を要する肺梗塞に対して抗菌薬使用なく経過した症例．, Jul. 2025.
16.	Shotaro Otani, Jun Oto, Taiga Itagaki, Takuya Takashima, Yoshitoyo Ueno, Toshiyuki Nunomura, Hiroki Sato, Kazuki Momota, Saki Saijo and Ryota Matsumoto : 胸腹部大動脈人工血管置換術後ICU管理中に，脊髄虚血による両下肢麻痺を生じた一例．, Jul. 2025.
17.	Yuta Arai, Takuya Takashima, Kazuki Momota, Saki Saijo, Hiroki Sato, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara, Masafumi Harada and Jun Oto : 人工呼吸中の気道出血に対して気管支動脈塞栓術が有用であった2 例．, Jul. 2025.
18.	Saki Saijo, Takuya Takashima, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara, Jun Oto, 森脇好乃美, Kazuki Momota and Hiroki Sato : 一酸化窒素吸入療法によりECMO導入を回避し得た一例．, Jul. 2025.
19.	Takuya Takashima, 大久保茉里奈, Saki Saijo, Natsuki Bando, Kazuki Momota, Hiroki Sato, Toshiyuki Nunomura, Manabu Ishihara, Yoshitoyo Ueno and Jun Oto : 優秀演題セッション「抜管前の陽圧換気が呼吸機能に与える影響の生理学的評価」, Jul. 2025.
20.	Yuta Arai, Takuya Takashima, Kazuki Momota, Saki Saijo, Hiroki Sato, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara, Masafumi Harada and Jun Oto : 人工呼吸中の気道出血に対して気管支動脈塞栓術が有用であった2例, 日本集中治療医学会第9回中国・四国支部学術集会, Jul. 2025.
21.	Saki Saijo, Kazuki Momota, Hiroki Sato, Takuya Takashima, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara and Jun Oto : 巨大胸腺腫摘出術後に人工呼吸器離脱の判断に苦慮した一例．, 第4回徳島外科医会(2月15日，徳島市), Feb. 2025.
22.	Saki Saijo : 悪性リンパ腫患者に発生したコリネバクテリウム菌血症の一例．, 第4回南四国集中治療医学シンポジウム(11月16日，高知市), Nov. 2024.
23.	Yuki Nakano, Saki Saijo, Natsuki Bando, Hiroki Sato, Kazuki Momota, Takuya Takashima, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara, Taiga Itagaki and Jun Oto : オルニチントランスカルバミラーゼ欠損症による難治性高アンモニア血症に対し集学的治療で神経学的後遺症なく救命できた小児症例．, 第52回日本救急医学会総会・学術集会(10月13∼15日，仙台市), Oct. 2024.
24.	Manabu Ishihara, Saki Saijo, Natsuki Bando, Kazuki Momota, Hiroki Sato, Yuki Nakano, Takuya Takashima, Toshiyuki Nunomura, Yoshitoyo Ueno, Taiga Itagaki and Jun Oto : くも膜下出血治療の現状と課題:救急科・脳神経外科のダブルボード専門医が行う神経集中治療．, 第52回日本救急医学会総会・学術集会(10月13∼15日，仙台市), Oct. 2024.
25.	Takuya Takashima, Momoyo Azuma, Saki Saijo, Natsuki Bando, Yuki Nakano, Toshiyuki Nunomura, Manabu Ishihara, Yoshitoyo Ueno, Taiga Itagaki and Jun Oto : 腎機能障害を有する深在性トリコスポロン症患者に対するイサブコナゾールでの治療経験．, 日本集中治療医学会第8回中国・四国支部学術集会(6月15∼16日，広島市), Jun. 2024.
26.	Manabu Ishihara, Natsuki Bando, Yoshitoyo Ueno, Saki Saijo, Yuki Nakano, Takuya Takashima, Taiga Itagaki and Jun Oto : ドラッグチャレンジテストが診断に有用であった遷延性意識障害の1例．, 日本集中治療医学会第8回中国・四国支部学術集会(6月15∼16日，広島市), Jun. 2024.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

気道3次元モデルの流体解析を用いた高流量鼻カニューラ酸素療法の効果予測法の開発 (Project/Area Number: 25K19876 )
Search by Researcher Number (81004645)

Assistant Professor : Saijo, Saki

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Academic Paper (Judged Full Paper):

Proceeding of Domestic Conference:

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)