徳島大学 / 教育研究者総覧 --- 杉本達朗

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徳島大学 ⟩ 病院 ⟩ 先端医科医療開発研究プロジェクト ⟩
徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 小児·周産·女性科 ⟩ 産科婦人科 ⟩
徳島大学 ⟩ 医学部 ⟩ 医学科 ⟩ 発生発達医学講座 ⟩ 産科婦人科学分野 ⟩

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著書・論文

学術論文(審査論文):

1.	Atsuko Yoshida, Takashi Kaji, Tatsuro Sugimoto, Ayuka Mineda, Shiroh Fujii and Takeshi Iwasa : Fatal Intratumoral Hemorrhage in Mediastinal Diffuse Large B-Cell Lymphoma During Pregnancy: A Case Report, The Journal of Obstetrics and Gynaecology Research, 52, 3, e70232, 2026. (要約) We report a pregnant woman with diffuse large B-cell lymphoma (DLBCL) presenting as a massive mediastinal tumor causing dyspnea. A 34-year-old multiparous woman was diagnosed with the tumor at 16 weeks of gestation. During attempts at airway management using ECMO cannulation and intubation, she developed cardiopulmonary arrest due to airway compromise but was resuscitated. R-CHOP chemotherapy was initiated empirically, and subsequent biopsy confirmed DLBCL, leading to continuation of therapy using DA-EPOCH-R. Despite repeated discussions, including the option of pregnancy termination, the patient strongly wished to continue the pregnancy. Partial tumor shrinkage was achieved; however, at 24 weeks, she developed sudden massive hemoptysis and cardiopulmonary arrest, which proved fatal despite resuscitation. Postmortem imaging demonstrated tumoral hemorrhage with bronchial communication. Although tumoral hemorrhage is a rare complication of lymphoma, it should be recognized as a possible cause of sudden death in malignant disease. This case highlightsthe potential for catastrophic tumoral hemorrhage during chemotherapy and the complex ethical dilemmas surrounding pregnancy continuation. (キーワード) diffuse large B-cell lymphoma / ECMO / malignant lymphoma / pregnancy / tumoral hemorrhage (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jog.70232 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41813081 ● Summary page in Scopus @ Elsevier: 2-s2.0-105032410738 (DOI: 10.1111/jog.70232, PubMed: 41813081, Elsevier: Scopus)

学術論文(紀要・その他):

1.	Takeshi Iwasa, Hiroki Noguchi, Risa Tanano, Erika Yamanaka, Asuka Takeda, Kou Tamura, Hidenori Aoki, Tatsuro Sugimoto, Hikari Sasada, Takaaki Maeda, Saki Minato, Shota Yamamoto, Hiroaki Inui, Tomohiro Kagawa, Atsuko Yoshida, Ayuka Mineda, Mari Nii, Riyo Kinouchi, Kanako Yoshida, Yuri Yamamoto and Takashi Kaji : Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals., International Journal of Molecular Sciences, 24, 23, 16567, 2023. (要約) In recent years, the effects of androgens on metabolic and body weight regulation systems and their underlying mechanisms have been gradually revealed in females. In women and experimental animals of reproductive age, androgen excess can adversely affect metabolic functioning, appetite, and body weight regulation. In addition, excess androgens can increase the risk of metabolic disorders, such as obesity, insulin resistance, and diabetes. These unfavorable effects of androgens are induced by alterations in the actions of hypothalamic appetite-regulatory factors, reductions in energy expenditure, insulin resistance in skeletal muscle, and β-cell dysfunction. Interestingly, these unfavorable effects of androgens on metabolic and body-weight regulation systems are neither observed nor evident in ovariectomized animals and post-menopausal women, indicating that the adverse effects of androgens might be dependent on the estrogen milieu. Recent findings may provide novel sex- and age-specific strategies for treating metabolic diseases. (キーワード) Animals / Humans / 女性 (female) / Androgens / Insulin Resistance / Obesity / Metabolic Diseases / Animals, Laboratory / Polycystic Ovary Syndrome (徳島大学機関リポジトリ) ● Metadata: 2000318 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ijms242316567 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38068890 ● Search Scopus @ Elsevier (PMID): 38068890 ● Search Scopus @ Elsevier (DOI): 10.3390/ijms242316567 (徳島大学機関リポジトリ: 2000318, DOI: 10.3390/ijms242316567, PubMed: 38068890)

その他・研究会:

1.	杉本達朗, 加地剛, 吉本夏実, 峯田あゆか, 吉田あつ子, 鈴江真史, 中川竜二, 石橋広樹, 岩佐武 : 胎児期にshort gapと診断し得たC型食道閉鎖の一例, 第121回徳島周産期研究会, 2025年6月.