Tokushima University / Educator and Researcher Directory --- Enomoto, Noriya

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Academic Paper (Judged Full Paper):

1.	Hiroshi Koyama, Kohhei Nakajima, Izumi Yamaguchi, Noriya Enomoto, Taku Matsuda, Hiroshi Kagusa, T. Keiko Kitazato and Yasushi Takagi : Cystatin C regulates cell division in primary central nervous system lymphoma, Scientific Reports, 16, 1, 2026. (Summary) Primary central nervous system lymphoma (PCNSL) is associated with cerebral inflammation characterized by elevated neutrophils, monocytes, platelets, and lymphocytes. However, the comprehensive profile of inflammation-related molecules in PCNSL remains unclear. In this study, we conducted proteomic analysis of PCNSL tissue compared with normal brain to identify factors influencing neuroinflammation and potential therapeutic targets. In contrast to the general elevation of inflammatory molecules, cystatin C (Cyst C) showed markedly reduced expression. This result was confirmed by western blotting and mRNA analysis. Immunohistochemistry revealed widespread Cyst C positivity in glial cells of the normal brain, whereas PCNSL tissue was dominated by Cyst C-negative B cells. To further investigate its role, cultured PCNSL cells were treated with recombinant human Cyst C. Treatment reduced viable cell counts in a dose- and time-dependent manner over 4 days without inducing cell death, indicating inhibition of cell division. Immunohistochemistry demonstrated that Cyst C increased p21 expression and decreased cyclin-dependent kinase 1 and Cyclin B. These findings identify Cyst C as a regulator of PCNSL cell division, highlighting it as a potential therapeutic target. (Keyword) Cell division / Cyclin-dependent kinases / Cystatin C / Neuroinflammation / p21 / Primary central nervous system lymphoma (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-026-44039-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41826426 ● Summary page in Scopus @ Elsevier: 2-s2.0-105040825194 (DOI: 10.1038/s41598-026-44039-w, PubMed: 41826426, Elsevier: Scopus)
2.	Andrea Berardino, Fabio Gallo, Denise Battaglini, Raphael Cinotti, Karim Asehnoune, R.M. Patricia Rocco, Silvio Fabio Taccone, Nicolo' Patroniti, J. Marcus Schultz, Andrea Barbanera, Alessandro Bertuccio, Luca Montagnani, Pietro Fiaschi, Gianluigi Zona, Sarah Wahlster, Chiara Robba, Norma la Torre Peredo de, Campos Ricardo Cerda, Nicholas Fong, Catherine Jean Digitale, Atef Mohammed Aza, Tariq Syed Reza, Muhammed Elhadi, Michaël Piagnerelli, Suei Abdurrahmaan Ali Elbuzidi, Rafael Badenes, Yoshitoyo Ueno, Aikaterini Ioakeimidou, Pablo Alvarez, Agustin Daniela Godoy, Callum Kaye, J. Marcus Schultz, Mohan Gurjar, Mattias Haënggi, Cesar Julio Mijangos, Samir Samal, Bedanta Shakti Mishra, Avinash Agrawal, Sulekha Saxena, Nicolas Mouclier, Soizic Gergaud, Sigismond Lasocki, Elodie Masseret, Yoann Launey, Ahmed Hashim, Mohamed Abdelaty, Abdelraouf Akkari, Romain Pirracchio, Mathieu der Jagt van, Job Steenkiste van, Nicolas Grillot, Yannick Hourmant, Chrysanthi Sklavou, Vasiliki Chantziara, Christos Papadas, Mozaffer Md Hossain, Alfredo Arellano, Adrian Gilberto Gasca, Yashbir Deewan, Sonika Agarwal, Sagarika Panda, Gaurav Jain, Andre Pierre Rodie-Talbere, Vincent Robert-Edan, Kumar Amarendra Jha, Ghanshyam Yadav, Carlos José García-Ramos, Forttino Galicia-Espinosa, Paul Meenen David Michael van, Ahmed Azzam, A. Mohammed Azab, Nubert Víctor Hugo Castillo, Velarde Ana Alicia Pineda, Jessie Welbourne, Edward Alexander Coombs, Hazem Ahmed, Marie Geslain, Olivier Huet, Benjamin Brochet, Vincent Legros, Mendoza Rocio Trujillo, J.Rivera Manuel Chavez, Luigi Vetrugno, Cristian Deana, Maria Palma Daniela, Neville Cracchiolo Andrea, Mohamed Ghula, Ala Khaled, Basheer Hana Yahya, Estefanía Prol-Silva, David Pérez-Torres, Baptiste Compagnon, Thomas Geeraerts, Miguel Lopez-Morales, John Porter, José Francisco Barbosa-Camacho, Carlos Roberto Miranda-Ackerman, Arvind Baronia, Delphine Georges, Matthieu Biais, et al. and Noriya Enomoto : Utilization of Neuromuscular Blocking Agents in Acute Brain Injury and Associations with Outcomes: A Post Hoc Analysis of the ENIO Study, Neurocritical Care, 45, 1, 294-303, 2026. (Summary) Neuromuscular blocking agents (NMBA) have been used in mechanically ventilated patients with moderate-to-severe acute respiratory distress syndrome (ARDS), in cases of clinically significant ventilator dyssynchrony, and in patients with elevated intracranial pressure (ICP). However, practice patterns around NMBA utilization and their impact on outcomes in acute brain injury (ABI) remain insufficiently explored. This study carried out a post hoc analysis of a multicenter, prospective observational study (NCT03400904) including adult patients with ABI (Glasgow Coma Scale 12 before intubation) who required invasive mechanical ventilation (IMV) 24 h. Patients who received NMBA during their first week of ICU stay were propensity matched to those who did not. Propensity score matching was performed in 1482 patients; among the matched cohort (n = 258), 33.3% (n = 86) received NMBA. NMBA utilization varied from 0% to 59.3% across countries. Multivariable regressions demonstrated associations between NMBA use and utilization of intraparenchymal ICP monitoring (odds ratio, OR 2.06; 95% confidence interval, CI 1.16-3.76), extraventricular drain placement (OR 2.18; 95% CI 1.18-4.05), higher PaCO₂ values (OR 1.04; 95% CI 1.01-1.09), and moderate-to-severe ARDS (OR 2.40; 95% CI 1.16-5.05). NMBA use was associated with lower hospital mortality (OR 0.35; 95% CI 0.11-0.99) and prolonged IMV duration (OR 1.56; 95% CI 1.38-1.76), but not with reintubation rates or tracheostomy placement. NMBA utilization varied widely, highlighting the need for more evidence to guide clinical practice. NMBA were most commonly used in patients with ICP monitoring or moderate-to-severe ARDS; associations with outcomes warrant further exploration in randomized controlled trials. (Keyword) Acute brain injury / Acute respiratory distress syndrome / Mechanical ventilation / Neuromuscular blocking agents / Stroke / Traumatic brain injury (Link to Publication Site) ● Publication site (DOI): 10.1007/s12028-026-02473-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41792523 ● Summary page in Scopus @ Elsevier: 2-s2.0-105034023906 ● Summary page in Scopus @ Elsevier: 2-s2.0-105041533417 (DOI: 10.1007/s12028-026-02473-8, PubMed: 41792523, Elsevier: Scopus, Elsevier: Scopus)
3.	Denise Battaglini, Shaurya Taran, Francesca Gualdi, Raphael Cinotti, Karim Asehnoune, Andrea Loggini, Luca Montagnani, R.M. Patricia Rocco, J. Marcus Schultz, Antonino Nicolò Patroniti, Chiara Robba, Robert Stevens, Romain Pirracchio, Norma Peredo, Ricardo Cerda, Nicholas Fong, Jean Digitale, Mohammed Azab, Syed Reza, Muhammed Elhadi, Michaël Piagnerelli, Suei Abdurrahmaan Elbuzidi, Rafael Badenes, Yoshitoyo Ueno, Aikaterini Ioakeimidou, Pablo Alvarez, Daniela Godoy, Callum Kaye, Marcus Schultz, Mohan Gurjar, Mattias Haënggi, Julio Mijangos, Samir Samal, Shakti Mishra, Avinash Agrawal, Sulekha Saxena, Nicolas Mouclier, Soizic Gergaud, Sigismond Lasocki, Elodie Masseret, Yoann Launey, Ahmed Hashim, Mohamed Abdelaty, Abdelraouf Akkari, Mathieu der Jagt van, Job Steenkiste van, Nicolas Grillot, Yannick Hourmant, Chrysanthi Sklavou, Vasiliki Chantziara, Christos Papadas, Mozaffer Md Hossain, Tariq Syed Reza, Alfredo Arellano, Gilberto Gasca, Yashbir Deewan, Sonika Agarwal, Sagarika Panda, Gaurav Jain, Andre Pierre Rodie-Talbere, Vincent Robert-Edan, Amarendra Jha, Ghanshyam Yadav, José García-Ramos, Forttino Galicia-Espinosa, David Meenen van, Y. Ahmed Azzam, A. Mohammed Azab, Víctor Castillo Nubert, Ana Pineda Velarde, Jessie Welbourne, Alexander Coombs, Hazem Ahmed, Marie Geslain, Olivier Huet, Benjamin Brochet, Vincent Legros, Rocio Trujillo, J. Manuel Chavez, Luigi Vetrugno, Cristian Deana, Daniela Palma, Andrea Cracchiolo, Mohamed Ghula, Ala Khaled, Hana Yahya, Estefanía Prol-Silva, David Pérez-Torres, Baptiste Compagnon, Thomas Geeraerts, Miguel Lopez-Morales, John Porter, Francisco Barbosa-Camacho, Roberto Miranda-Ackerman, Arvind Baronia, Delphine Georges, Matthieu Biais, Jose Orquera, Laura Lamot, Maria Haedo Gomez, et al. and Noriya Enomoto : Spontaneous breathing trials as predictors of extubation outcomes in neurocritical care: insights from the ENIO study, Intensive Care Medicine, 52, 2, 252-262, 2026. (Summary) In critically ill patients, extubation readiness is typically assessed using a spontaneous breathing trial (SBT). Among patients with acute brain injury (ABI), the optimal SBT method remains uncertain. We conducted a post-hoc analysis of the ENIO study (NCT03400904), including mechanically ventilated ABI patients with available SBT data, undergoing extubation attempt. SBTs were classified as T-piece, pressure support ventilation (PSV), or continuous positive airway pressure (CPAP). The primary outcome was extubation failure within 5 days. Associations between SBT modality and extubation failure were assessed using multivariable logistic regression and inverse probability of treatment weighting. Of 1,512 patients enrolled in ENIO, 839 met the inclusion criteria, of whom 270 (32.2%) were female and 396 (47.2%) had traumatic brain injury as the cause of admission. SBTs were performed with PSV in 430 (51.3%), T-piece in 329 (39.2%), and CPAP in 80 (9.5%). SBT median duration was 60 min in PSV and T-piece, while 120 min in CPAP. Extubation failure occurred in 177 (21.1%) cases. In multivariable analyses, there was no significant association between SBT modality or duration and extubation outcome. Results were similar in ABI subgroup analyses. After inverse probability weighting, vigorous cough remained the only significant predictor of extubation success. In this large international ABI cohort, neither SBT mode nor duration was associated with extubation failure. (Keyword) Acute brain injury / Critically ill / Extubation / Mechanical ventilation / Spontaneous breathing trial / Weaning (Link to Publication Site) ● Publication site (DOI): 10.1007/s00134-025-08258-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41528453 ● Summary page in Scopus @ Elsevier: 2-s2.0-105027793482 (DOI: 10.1007/s00134-025-08258-5, PubMed: 41528453, Elsevier: Scopus)
4.	Kenji Shimada, Izumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Hiroshi Koyama, Noriya Enomoto, Alfredo Shimabuku, T. Keiko Kitazato, Yasuhisa Kanematsu and Yasushi Takagi : Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission, Journal of the American Heart Association, 14, 24, 1-11, 2025. (Summary) Cerebral arteriovenous malformations (cAVMs) are complex vascular anomalies carrying a high risk of hemorrhage due to abnormal arteriovenous connections. Recent studies have highlighted the roles of inflammation and KRAS mutations in the pathogenesis of cAVM. Necroptosis is a programmed cell necrosis pathway mediated by RIPK3 (receptor-interacting protein kinase 3) and MLKL (mixed-lineage kinase domain-like protein). The pathway, which is inhibited by caspase-8, plays multifunctional roles in various diseases. However, the involvement of necroptosis and its relationship with caspase-8 in the pathogenesis of cAVM remain unclear. We analyzed tissue samples from 23 patients with cAVM in comparison with normal brain tissues. Proteome profiling, immunohistochemistry, and quantitative polymerase chain reaction assays were used to assess the expression of inflammatory molecules and programmed cell death markers. Protein and gene expression of necroptosis-related molecules (RIPK3, MLKL), caspase-8, and IL-6 (interleukin-6) and IL-8 were significantly elevated in cAVM nidi compared with normal brain tissue. High MLKL protein expression was associated with severe clinical presentations and hemorrhage, whereas caspase-8 protein expression was elevated in less-severe cases and unruptured cAVM. Our analysis of human samples offers the first evidence of necroptosis-related molecules acting against caspase-8 in association with the inflammatory cytokines IL-6 and IL-8 in the pathogenesis of cAVM. The balance between MLKL and caspase-8 expression may be linked to the clinical condition and hemorrhagic presentation of patients with cAVM on admission. (Keyword) caspase-8 / cerebral arteriovenous malformation / interleukin-6 / interleukin-8 / necroptosis (Link to Publication Site) ● Publication site (DOI): 10.1161/JAHA.125.044575 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41378489 ● Summary page in Scopus @ Elsevier: 2-s2.0-105025238011 (DOI: 10.1161/JAHA.125.044575, PubMed: 41378489, Elsevier: Scopus)
5.	Tomohiro Matsuda, Mami Hanaoka, Takeshi Miyamoto, Noriya Enomoto, Hitoshi Niki, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi : Low-profile visualized intraluminal support junior-within-enterprise 2 stent technique for a distal middle cerebral artery fusiform aneurysm: A case report., Surgical Neurology International, 16, 2025. (Summary) Aneurysms distal to the M2 segment account for 2-7% of middle cerebral artery (MCA) aneurysms. These aneurysms, which are often small and fusiform, have thin walls and are prone to bleeding. Therefore, neck clipping and aneurysmal coil embolization are difficult to perform. Herein, we report a case of distal MCA fusiform thrombosed large aneurysm in which the patient underwent overlapping stent with coil embolization.A 28-year-old man presented to our hospital due to sudden headache onset. Computed tomography revealed a subarachnoid hemorrhage and oval lesion with calcification in the left sylvian fissure. Digital subtraction angiography revealed an 8-mm fusiform aneurysm in the M2 and M3 segments of the left MCA. We performed palliative coil embolization of the saccular portion of the aneurysm. The patient was discharged 22 days after presentation. Imaging performed 2 months after the initial treatment revealed aneurysm enlargement. Because the patient refused to undergo craniotomy, we performed coil embolization with an overlapping stent. An Enterprise 2 stent was deployed to sufficiently cover the aneurysmal segment. Subsequently, an low-profile visualized intraluminal support junior (LVIS Jr.) stent was placed inside the Enterprise 2 stent, and additional coil embolization was performed. Follow-up imaging 5 months after the second treatment revealed complete resolution of the aneurysm.The LVIS Jr.-within-Enterprise 2 stent technique may resolve fusiform aneurysms located in distal arteries and maintain parent artery patency. (Link to Publication Site) ● Publication site (DOI): 10.25259/SNI_717_2025 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41112365 ● Search Scopus @ Elsevier (PMID): 41112365 ● Search Scopus @ Elsevier (DOI): 10.25259/SNI_717_2025 (DOI: 10.25259/SNI_717_2025, PubMed: 41112365)
6.	Relin Vliet van, M.P. Meenen David van, Chiara Robba, Raphaël Cinotti, Karim Asehnoune, D. Robert Stevens, Denise Battaglini, Shaurya Taran, Mathieu der Jagt van, Silvio Fabio Taccone, Frederique Paulus, J. Marcus Schultz, sélim Paër Abback, Anaïs Codorniu, Giuseppe Citerio, Ludovica Vittoria Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Giuseppina Jessica Maugeri, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Chiara Robba, Denise Battaglini, Patrick Biston, Fathi Mohamed Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter Vliet van, Marcel Benjamin Gerretsen, Xochitl Iris Ortiz-macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, J. Wytze Vermeijden, Daniel Alexander Cornet, Reyes Sergio Inurrigarro, Lara Rafael Cirino Domínguez, Mercedes Maria Bellini, Milagros Maria Gomez-Haedo, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronia, Carlos Roberto Miranda-Ackerman, José Francisco Barbosa-Camacho, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Compagnon, David Pérez-Torres, Estefanía Prol-Silva, Basheer Hana Yahya, Ala Khaled, Mohamed Ghula, Cracchiolo Andrea Neville, Daniela Maria Palma, Cristian Deana, Luigi Vetrugno, J. Chavez Manuel Rivera, Mendoza Rocio Trujillo, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu der Jagt van, Job Steenkiste van, Hazem Ahmed, Edward Alexander Coombs, Jessie Welbourne, Velarde Ana Alicia Pineda, Nubert Víctor Hugo Castillo, A. Mohammed Azab, Y. Ahmed Azzam, M.P. Meenen David van, Adrian Gilberto Gascav, Alfredo Arellano, Forttino Galicia-Espinosa, Carlos José García-Ramos, Ghanshyam Yadav, Kumar Amarendra Jha, Vincent Robert-Edan, Andre Pierre Rodie-Talbere, et al. and Yoshitoyo Ueno : Association of age with extubation failure in neurocritical intensive care unit patients--Insight from an international prospective study named ENIO, Journal of Critical Care, 88, 155067, 2025. (Summary) To assess the association of age with extubation failure in neurocritical care patients. Posthoc analysis of the 'Extubation strategies in Neuro-Intensive care unit patients and associations with Outcomes (ENIO) study', an international prospective observational study. ENIO was conducted in 73 centers in 18 countries from 2018 to 2020. Neurocritical care patients with a Glasgow Coma Scale score 12 and receiving ventilationfor at least 24 h were included. We categorized patients into four age groups based on age quartiles. This analysis included 1095 patients with a median age of 53 [35 to 65] years. Younger patients were more likely to be admitted with traumatic brain injury, whereas older patients more often had cerebral hemorrhage, ischemic stroke, central nervous infection, or brain malignancies. Extubation failure occurred in 209 (19 %) patients. In the unadjusted analysis, older patients had a higher risk of extubation failure (odds ratio (OR), 1.012 [95 %-confidence interval (CI) 1.004 to 1.021]; P = 0.006). However, after adjusting for confounding factors, the effect of age on extubation failure was no longer significant (OR, 1.008 [0.997 to 1.019]; P = 0.172). In this international cohort of intubated and ventilated neurocritical care patients, after adjusting for baseline covariates and for previously identified risk factors for extubation failure, age was not associated with extubation failure. Age may not be a factor to consider in extubation decisions for brain-injured patients. ENIO is registered at clinicaltrials.gov (study identifier NCT03400904). (Keyword) Age groups / Airway extubation / Brain injury / Critical care / Mechanical / Ventilators (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcrc.2025.155067 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40184992 ● Summary page in Scopus @ Elsevier: 2-s2.0-105001693301 (DOI: 10.1016/j.jcrc.2025.155067, PubMed: 40184992, Elsevier: Scopus)
7.	Nan Shi Feng, Camilo Diaz-Cruz, Raphael Cinotti, Karim Asehnoune, J. Marcus Schultz, S. Gentle Shrestha, R. Paula Sanches, Chiara Robba, Min Sung Cho, Victoria Credie Mc, David Robert Stevens, Romain Pirracchio, Norma la Torre Peredo de, Campos Ricardo Cerda, Nicholas Fong, Catherine Jean Digitale, Atef Mohammed Azab, Tariq Syed Reza, Muhammed Elhadi, Michaël Piagnerelli, Ali Elbuzidi Abdurrahmaan Suei, Rafael Badenes, Yoshitoyo Ueno, Aikaterini Ioakeimidou, Pablo Alvarez, Agustin Daniela Godoy, Callum Kaye, Mohan Gurjar, Mattias Haënggi, Cesar Julio Mijangos, Samir Samal, Bedanta Shakti Mishra, Avinash Agrawal, Sulekha Saxena, Nicolas Mouclier, Soizic Gergaud, Sigismond Lasocki, Elodie Masseret, Yoann Launey, Ahmed Hashim, Mohamed Abdelaty, Abdelraouf Akkari, Mathieu der Jagt van, Job Steenkiste van, Nicolas Grillot, Yannick Hourmant, Sklavou Greece, Vasiliki Chantziara, Christos Papadas, Mozaffer Md Hossain, Alfredo Arellano, Adrian Gilberto Gasca, Yashbir Deewan, Sonika Agarwal, Sagarika Panda, Gaurav Jain, Andre Pierre Rodie-Talbere, Vincent Robert-Edan, Kumar Amarendra Jha, Ghanshyam Yadav, Carlos José García-Ramos, Forttino Galicia-Espinosa, Paul Meenen David Michael van, Y. Ahmed Azzam, A. Mohammed Azab, Hugo Castillo Víctor Nubert, Alicia Pineda Ana Velarde, Jessie Welbourne, Edward Alexander Coombs, Hazem Ahmed, Marie Geslain, Olivier Huet, Benjamin Brochet, Vincent Legros, Mendoza Rocio Trujillo, J.Rivera Manuel Chavez, Luigi Vetrugno, Cristian Deana, Maria Palma Daniela, Neville Cracchiolo Andrea, Mohamed Ghula, Ala Khaled, Basheer Hana Yahya, Estefanía Prol-Silva, David Pérez-Torres, Baptiste Compagnon, Thomas Geeraerts, Miguel Lopez-Morales, John Porter, José Francisco Barbosa-Camacho, Carlos Roberto Miranda-Ackerman, Arvind Baronia, Delphine Georges, Matthieu Biais, Jose Orquera, Laura Lamot, Milagros Haedo Maria Gomez, Mercedes Maria Bellini, Lara Rafael Cirino Domínguez, Reyes Sergio Inurrigarro, et al. and Noriya Enomoto : Impact of Country Income Level on Outcomes in Patients with Acute Brain Injury Requiring Invasive Mechanical Ventilation: A Secondary Analysis of the ENIO Study, Neurocritical Care, 43, 1, 243-253, 2025. (Link to Publication Site) ● Publication site (DOI): 10.1007/s12028-024-02198-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39776347 ● Summary page in Scopus @ Elsevier: 2-s2.0-85215529436 ● Summary page in Scopus @ Elsevier: 2-s2.0-105042277719 (DOI: 10.1007/s12028-024-02198-6, PubMed: 39776347, Elsevier: Scopus, Elsevier: Scopus)
8.	Nan Shi Feng, H. Lindsay Laws, Camilo Diaz-Cruz, Raphael Cinotti, J. Marcus Schultz, Karim Asehnoune, D. Robert Stevens, Chiara Robba, Sung-Min Cho, Robert Stevens, Romain Pirracchio, Norma Peredo, Ricardo Cerda, Nicholas Fong, Jean Digitale, Mohammed Azab, Syed Reza, Muhammed Elhadi, Michaël Piagnerelli, Abdurrahmaan Elbuzidi Suei, Rafael Badenes, Yoshitoyo Ueno, Aikaterini Ioakeimidou, Pablo Alvarez, Daniela Godoy, Callum Kaye, Marcus Schultz, Mohan Gurjar, Mattias Haënggi, Julio Mijangos, Samir Samal, Shakti Mishra, Avinash Agrawal, Sulekha Saxena, Nicolas Mouclier, Soizic Gergaud, Sigismond Lasocki, Elodie Masseret, Yoann Launey, Ahmed Hashim, Mohamed Abdelaty, Abdelraouf Akkari, Mathieu der Jagt van, Job Steenkiste van, Nicolas Grillot, Yannick Hourmant, Chrysanthi Sklavou, Vasiliki Chantziara, Christos Papadas, Mozaffer Md Hossain, Tariq Syed Reza, Alfredo Arellano, Gilberto Gasca, Yashbir Deewan, Sonika Agarwal, Sagarika Panda, Gaurav Jain, Andre Pierre Rodie-Talbere, Vincent Robert-Edan, Amarendra Jha, Ghanshyam Yadav, José García-Ramos, Forttino Galicia-Espinosa, David Meenen van, Y. Ahmed Azzam, A. Mohammed Azab, Víctor Castillo Nubert, Ana Pineda Velarde, Jessie Welbourne, Alexander Coombs, Hazem Ahmed, Marie Geslain, Olivier Huet, Benjamin Brochet, Vincent Legros, Rocio Trujillo, J. Manuel Chavez, Luigi Vetrugno, Cristian Deana, Palma Daniela, Cracchiolo Andrea, Mohamed Ghula, Ala Khaled, Hana Yahya, Estefanía Prol-Silva, David Pérez-Torres, Baptiste Compagnon, Thomas Geeraerts, Miguel Lopez-Morales, John Porter, Francisco Barbosa-Camacho, Roberto Miranda-Ackerman, Arvind Baronia, Delphine Georges, Matthieu Biais, Jose Orquera, Laura Lamot, Maria Haedo Gomez, Maria Bellini, Cirino Rafael Domínguez, et al. and Noriya Enomoto : Sedation Practices in Mechanically Ventilated Neurocritical Care Patients from 19 Countries: An International Cohort Study, Neurocritical Care, 43, 1, 232-242, 2025. (Link to Publication Site) ● Publication site (DOI): 10.1007/s12028-024-02200-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39776348 ● Summary page in Scopus @ Elsevier: 2-s2.0-85215527722 ● Summary page in Scopus @ Elsevier: 2-s2.0-105039440304 (DOI: 10.1007/s12028-024-02200-1, PubMed: 39776348, Elsevier: Scopus, Elsevier: Scopus)
9.	Tomohiro Matsuda, Mami Hanaoka, Noriya Enomoto, Tadashi Yamaguchi, Takeshi Miyamoto, Hitoshi Niki and Kazuhito Matsuzaki : Combined Mechanical Thrombectomy for Multiple Cerebral Venous Sinus Thrombosis Involving the Straight Sinus: A Case Report., NMC Case Report Journal, 11, 227-231, 2024. (Summary) The proportion of cerebral venous sinus thrombosis involving the straight sinus (StS) is low, and the prognosis is poor. We report a case of multiple sinus thrombosis involving StS in which the patient underwent mechanical thrombectomy (MT) using a stent retriever and an aspiration catheter (combined MT) with a good postoperative course. A 15-year-old girl was admitted to our hospital with rapid loss of consciousness. Magnetic resonance imaging (MRI) revealed thrombosis of the bilateral internal cerebral veins, vein of Galen, StS, torcular herophili (TH), and right transverse sinus (TS), as well as edema mainly in the left thalamus, basal ganglia, and corpus callosum. Systemic heparinization was initiated, and combined MT was performed. Although complete recanalization of the TH and right TS via the left internal jugular vein was achieved, the microwire could not be advanced to the StS. Hence, the approach route was changed to remove the thrombus from the superior sagittal sinus and successfully reach the StS via the right TS. Partial recanalization of the StS was achieved, and venous congestion was improved. Two months after MT, the patient returned to school without neurological deficits. MRI performed 3 months after MT revealed disappearance of the edema and complete recanalization of the StS. In this case, StS catheterization via the left TS was not possible. However, we could reach the right TS, which were recanalized first. Partial recanalization of the StS can be expected a good prognosis under the patency of the TH and TS. (Link to Publication Site) ● Publication site (DOI): 10.2176/jns-nmc.2024-0077 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39224239 ● Search Scopus @ Elsevier (PMID): 39224239 ● Search Scopus @ Elsevier (DOI): 10.2176/jns-nmc.2024-0077 (DOI: 10.2176/jns-nmc.2024-0077, PubMed: 39224239)
10.	Noriya Enomoto, Kazuhito Matsuzaki, Tomohiro Matsuda, Tadashi Yamaguchi, Takeshi Miyamoto, Mami Hanaoka, Natsumi Teshima, Ayato Kageyama, Yuichi Satoh, Tatsuya Haboshi, Masaaki Korai, Kenji Shimada, Hitoshi Niki, Koichi Satoh and Yasushi Takagi : Effectiveness of hinge craniotomy as an alternative to decompressive craniectomy for acute subdural hematoma, Acta Neurochirurgica, 166, 1, 272, 2024. (Summary) Acute subdural hematoma (ASDH) is a life-threatening condition, and hematoma removal is necessary as a lifesaving procedure when the intracranial pressure is highly elevated. However, whether decompressive craniectomy (DC) or conventional craniotomy (CC) is adequate remains unclear. Hinge craniotomy (HC) is a technique that provides expansion potential for decompression while retaining the bone flap. At our institution, HC is the first-line operation instead of DC for traumatic ASDH, and we present the surgical outcomes. From January 1, 2017, to December 31, 2022, 372 patients with traumatic ASDH were admitted to our institution, among whom 48 underwent hematoma evacuation during the acute phase. HC was performed in cases where brain swelling was observed intraoperatively. If brain swelling was not observed, CC was selected. DC was performed only when the brain was too swollen to allow replacement of the bone flap. We conducted a retrospective analysis of patient demographics, prognosis, and subsequent cranial procedures for each technique. Of the 48 patients, 2 underwent DC, 23 underwent HC, and 23 underwent CC. The overall mortality rate was 20.8% (10/48) at discharge and 30.0% (12/40) at 6 months. The in-hospital mortality rates for DC, HC, and CC were 100% (2/2), 21.7% (5/23), and 13.0% (3/23), respectively. Primary brain injury was the cause of death in five patients whose brainstem function was lost immediately after surgery. No fatalities were attributed to the progression of postoperative brain herniation. In only one case, the cerebral contusion worsened after the initial surgery, leading to brain herniation and necessitating secondary DC. The strategy of performing HC as the first-line operation for ASDH did not increase the mortality rate compared with past surgical reports and required secondary DC in only one case. (Keyword) Acute subdural hematoma / Decompressive craniectomy / Head trauma / Hinge craniotomy (Tokushima University Institutional Repository) ● Metadata: 2013654 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00701-024-06167-y (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38888676 ● Summary page in Scopus @ Elsevier: 2-s2.0-85196175463 (Tokushima University Institutional Repository: 2013654, DOI: 10.1007/s00701-024-06167-y, PubMed: 38888676, Elsevier: Scopus)
11.	Shaurya Taran, Bastien Perrot, Federico Angriman, Raphael Cinotti, Sélim Paër Abback, Anaïs Codorniu, Giuseppe Citerio, Vittoria Sala Ludovica, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Jessica Maugeri Giuseppina, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Chiara Robba, Denise Battaglini, Patrick Biston, Mohamed Al-Gharyani Fathi, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter Vliet Van, Benjamin Gerretsen Marcel, Iris Ortiz-Macias Xochitl, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, J. Wytze Vermeijden, Alexander Cornet Daniel, Sergio Inurrigarro Reyes, Rafael Lara Domínguez Cirino, Maria Bellini Mercedes, Maria Gomez Haedo Milagros, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronia, Roberto Miranda-Ackerman Carlos, Francisco Barbosa-Camacho José, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Compagnon, David Pérez-Torres, Estefanía Prol-Silva, Hana Yahya Basheer, Ala Khaled, Mohamed Ghula, Cracchiolo Andrea Neville, Palma Daniela Maria, Cristian Deana, Luigi Vetrugno, J. Chavez Manuel Rivera, Rocio Trujillo Mendoza, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu Der Jagt Van, Job Steenkiste Van, Hazem Ahmed, Alexander Coombs Edward, Jessie Welbourne, Alicia Pineda Ana Velarde, Hugo Castillo Víctor Nubert, A. Mohammed Azab, Y. Ahmed Azzam, Michael Van Meenen David Paul, Gilberto Gasca Adrian, Alfredo Arellano, Forttino Galicia-Espinosa, José García-Ramos Carlos, Ghanshyam Yadav, Amarendra Jha Kumar, Vincent Robert-Edan, Andre Pierre Rodie-Talbere, Gaurav Jain, Sagarika Panda, Sonika Agarwal, Yashbir Deewan, Gilberto Gasca Adrian, Alfredo Arellano, Syed Reza Tariq, Mozaffer Md Hossain, et al. and Yoshitoyo Ueno : Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients with Acute Brain Injury, Critical Care Medicine, 52, 8, 1258-1263, 2024. (Summary) To evaluate the association between the pre-extubation sum of eye and motor components of the Glasgow Coma Score (GCS-EM) and odds of extubation failure in patients with acute brain injury being liberated from mechanical ventilation. Secondary analysis of a prospective, multicenter observational study ( ClinicalTrials.gov identifier NCT03400904). Sixty-three hospital sites worldwide, with patient recruitment from January 2018 to November 2020. One thousand one hundred fifty-two critically ill patients with acute brain injury, with a median age of 54 years, of whom 783 (68.0%) were male, 559 (48.5%) had traumatic brain injury, and 905 (78.6%) had a GCS-EM greater than 8 before extubation (scores range from 2 to 10). None. GCS-EM was computed in intubated patients on the day of extubation. The main outcome was extubation failure, defined as unplanned reintubation within 5 days of extubation. Analyses used multilevel logistic regression with adjustment for patient characteristics and a random intercept for hospital site. In the primary analysis, GCS-EM was not associated with extubation failure (odds ratio, 1.07 per additional point; 95% CI, 0.87-1.31). Findings were consistent in sensitivity analyses that: 1) used different adjustment covariates, 2) included a verbal estimate to derive an overall GCS, 3) accounted for missing data, 4) considered a 2-day time interval to define extubation failure, 5) accounted for competing risks, and 6) used a propensity score-based model. There was no association between GCS-EM and extubation outcome in subgroups defined by brain injury diagnosis or age. In this large, contemporary, multicenter cohort of patients with acute brain injury, we found no association between the GCS-EM and odds of extubation failure. However, few patients had a pre-extubation GCS-EM less than or equal to 8, and the possibility of a true prognostic association in patients with low scores is not excluded. (Keyword) acute brain injury / extubation failure / Glasgow Coma Score / mechanical ventilation / ventilator liberation (Link to Publication Site) ● Publication site (DOI): 10.1097/CCM.0000000000006283 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38557684 ● Summary page in Scopus @ Elsevier: 2-s2.0-85198995942 (DOI: 10.1097/CCM.0000000000006283, PubMed: 38557684, Elsevier: Scopus)
12.	Chiara Robba, Denise Battaglini, Abbas Abbas, Ezequiel Sarrió, Raphael Cinotti, Karim Asehnoune, Fabio S. Taccone, Patricia R. Rocco, Marcus J. Schultz, Giuseppe Citerio, Robert David Stevens, Rafael Badenes, Paër-Sélim Abback, Anaïs Codorniu, Giuseppe Citerio, Vittoria Ludovica Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Jessica Giuseppina Maugeri, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Chiara Robba, Denise Battaglini, Patrick Biston, Mohamed Fathi Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter van Vliet, Benjamin Marcel Gerretsen, Iris Xochitl Ortiz-Macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, Wytze J. Vermeijden, Alexander Daniel Cornet, Sergio Infra Reyes Gard, Rafael Lara Cirino Domínguez, Maria Mercedes Bellini, Maria Gomez Milagros Haedo, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronial, Roberto Carlos Miranda-Ackerman, Francisco José Barbosa-Camacho, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Companion, David Pérez-Torres, Estefanía Prol-Silva, Hana Basheer Yahya, Ala Khaled, Mohamed Ghulam, Cracchiolo Neville Andrea, Palma Maria Daniela, Cristian Deana, Luigi Vetrugno, Manuel Rivera J. Chavez, Rocio Mendoza Trujillo, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu der van Jagt, Job van Steenkiste, Hazem Ahmed, Alexander Edward Coombs, Jessie Welbourne, Ana Velarde Alicia Pineda, Víctor Nubert Hugo Castillo, Mohammed A. Azab, Ahmed Y. Azzam, David van Paul Michael Meenen, Gilberto Adrian Gasca, Alfredo Arellano, Forttino Galicia-Espinosa, José Carlos García-Ramos, Ghanshyam Yadav, Amarendra Kumar Jha, Vincent Robert-Edan, Pierre-Andre Rodie-Talbere, Gaurav Jain, Sagarika Panda, Sonika Agarwal, Yashbir Deewan, Gilberto Adrian Gasca, Alfredo Arellano, Syed Tariq Reza, Md. Mozaffer Hossain, Christos Papadas, Vasiliki Chantziara, Chrysanthi Sklavou, Yannick Hourmant, Nicolas Grillot, Job van Steenkiste, Mathieu der van Jagt, Romain Pirracchio, Abdelraouf Akkari, Mohamed Abdelaty, Ahmed Hashim, Yoann Launey, Elodie Masseret, Sigismond Lasocki, Gergaud Soizic, Nicolas Mouclier, Sulekha Saxena, Avinash Agrawal, Shakti Bedanta Mishra, Samir Samal, Julio Cesar Mijangos, Mattias Haënggi, Mohan Gurjar, Marcus J. Schultz, Callum Kaye, Daniela Agustin Godoy, Pablo Alvarez, Aikaterini Ioakeimidou, Yoshitoyo Ueno, Rafael Badenes, Abdurrahmaan Suei Ali Elbuzidi, Michaël Piagnerelli, Muhammed Elhadi, Syed Tariq Reza, Mohammed Atef Azab, Jean Catherine Digitale, Nicholas Fong, Ricardo Campos Cerda, Norma Torre la de Peredo, Victoria McCredie, Elbuzidi Ali Abdurrahmaan Suei, Matthias Haenggi and Jaber Samir : Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study., Intensive Care Medicine, 50, 2, 234-246, 2024. (Summary) The use of arterial partial pressure of carbon dioxide (PaCO₂) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO₂ in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO₂ values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO₂ with in-hospital mortality. We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO₂ was collected on day 1, 3, and 7 from ICU admission. Normocapnia was defined as PaCO₂ > 35 and to 45 mmHg; mild hypocapnia as 32-35 mmHg; severe hypocapnia as 26-31 mmHg, forced hypocapnia as < 26 mmHg, and hypercapnia as > 45 mmHg. 1476 patients (65.9% male, mean age 52 <mml:mo>±</mml:mo> 18 years) were included. On ICU admission, 804 (54.5%) patients were normocapnic (incidence 1.37 episodes per person/day during ICU stay), and 125 (8.5%) and 334 (22.6%) were mild or severe hypocapnic (0.52 and 0.25 episodes/day). Forced hypocapnia and hypercapnia were used in 40 (2.7%) and 173 (11.7%) patients. PaCO₂ had a U-shape relationship with in-hospital mortality with only severe hypocapnia and hypercapnia being associated with increased probability of in-hospital mortality (omnibus p value = 0.0009). Important differences were observed across different subgroups of ABI patients. Normocapnia and mild hypocapnia are common in ABI patients and do not affect patients' outcome. Extreme derangements of PaCO₂ values were significantly associated with increased in-hospital mortality. (Keyword) Adult / Humans / male / female / carbon dioxide / Hypocapnia / Respiration, Artificial / Hypercapnia / brain (Link to Publication Site) ● Publication site (DOI): 10.1007/s00134-023-07305-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38294526 ● Summary page in Scopus @ Elsevier: 2-s2.0-85183773177 ● Summary page in Scopus @ Elsevier: 2-s2.0-85186742172 (DOI: 10.1007/s00134-023-07305-3, PubMed: 38294526, Elsevier: Scopus, Elsevier: Scopus)
13.	Carolina Iaquaniello, Fabio Gallo, Raphael Cinotti, Giuseppe Citerio, S. Fabio Taccone, Paolo Pelosi, Rafael Badenes, Chiara Robba, Sélim Paër Abback, Anaïs Codorniu, Ludovica Vittoria Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Giuseppina Jessica Maugeri, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Denise Battaglini, Patrick Biston, Fathi Mohamed Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter Vliet Van, Marcel Benjamin Gerretsen, Xochitl Iris Ortiz-Macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, J. Wytze Vermeijden, Daniel Alexander Cornet, Reyes Sergio Inurrigarro, Lara Rafael Cirino Domínguez, Mercedes Maria Bellini, Gomez Maria Milagros Haedo, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronia, Carlos Roberto Miranda-Ackerman, José Francisco Barbosa-Camacho, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Compagnon, David Pérez-Torres, Estefanía Prol-Silva, Basheer Hana Yahya, Ala Khaled, Mohamed Ghula, Andrea Neville Cracchiolo, Daniela Maria Palma, Cristian Deana, Luigi Vetrugno, J. Chavez Manuel Rivera, Mendoza Rocio Trujillo, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu Der Jagt Van, Job Steenkiste Van, Hazem Ahmed, Edward Alexander Coombs, Jessie Welbourne, Velarde Ana Alicia Pineda, Nubert Víctor Hugo Castillo, A. Mohammed Azab, Y. Ahmed Azzam, Paul Meenen David Michael Van, Adrian Gilberto Gasca, Alfredo Arellano, Forttino Galicia-Espinosa, Carlos José García-Ramos, Ghanshyam Yadav, Kumar Amarendra Jha, Vincent Robert-Edan, Andre Pierre Rodie-Talbere, Gaurav Jain, Sagarika Panda, Sonika Agarwal, Yashbir Deewan, Adrian Gilberto Gasca, Alfredo Arellano, et al. and Yoshitoyo Ueno : The use of tier three therapies in acute brain injured patients: Insight from the Extubation strategies in Neuro-Intensive care unit patients and associations with Outcomes observational study, European Journal of Anaesthesiology and Intensive Care, 3, 1, e0043, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1097/EA9.0000000000000043 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85205449218 (DOI: 10.1097/EA9.0000000000000043, Elsevier: Scopus)
14.	Natsumi Teshima, Kazuhito Matsuzaki, Noriya Enomoto, Masaaki Korai, Yoshitaka Kurashiki, Mami Hanaoka, Hitoshi Niki and Koichi Satoh : Case of Cerebrospinal Fluid Leakage Nine Years after Pituitary Gamma Knife Surgery for Poststroke Thalamic Pain Syndrome., NMC Case Report Journal, 10, 209-213, 2023. (Summary) Pituitary gamma knife surgery (GKS) is a treatment option for poststroke thalamic pain syndrome. Complications such as hypopituitarism, transient enuresis, and transient hyponatremia have been reported. However, cerebrospinal fluid (CSF) leakage has not yet been reported as a complication of pituitary GKS for poststroke thalamic pain syndrome. Herein, we report a case of delayed CSF rhinorrhea that developed 9 years after GKS for poststroke thalamic pain syndrome. A 64-year-old man presented to our hospital with bacterial meningitis and CSF rhinorrhea. Pituitary GKS for poststroke thalamic pain had been performed 9 years prior to his admission to our hospital. Computed tomography revealed pneumocephalus, fluid in the sphenoid and maxillary sinuses, and a partial bony defect of the sella turcica floor with communication between the paranasal and intracranial spaces. The CSF rhinorrhea resolved with bed rest and a lumbar CSF drain but recurred several days later. The patient underwent direct endoscopic surgical repair of the skull base. The sellar floor was covered with an autologous fascia graft harvested from the rectus sheath, and the sphenoid sinus was packed with abdominal fat grafts. The patient recovered, and the CSF rhinorrhea has not recurred for 2 years. Long-term follow-up is necessary after pituitary GKS, considering the complication of delayed CSF leakage. (Tokushima University Institutional Repository) ● Metadata: 2012239 (Link to Publication Site) ● Publication site (DOI): 10.2176/jns-nmc.2022-0224 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37539363 ● Search Scopus @ Elsevier (PMID): 37539363 ● Search Scopus @ Elsevier (DOI): 10.2176/jns-nmc.2022-0224 (Tokushima University Institutional Repository: 2012239, DOI: 10.2176/jns-nmc.2022-0224, PubMed: 37539363)
15.	Chiara Robba, Denise Battaglini, Raphael Cinotti, Karim Asehnoune, Robert Stevens, Fabio Silvio Taccone, Rafael Badenes, Paolo Pelosi, Paër-Sélim Abback, Anaïs Codorniu, Giuseppe Citerio, Vittoria Ludovica Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Jessica Giuseppina Maugeri, Bellissima Agrippino, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Mohamed Fathi Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter van Vliet, Benjamin Marcel Gerretsen, Iris Xochitl Ortiz-Macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, Wytze J Vermeijden, Alexander Daniel Cornet, Sergio Reyes Inurrigarro, Rafael Lara Cirino Domínguez, Maria Mercedes Bellini, Maria Milagros Gomez-Haedo, Laura Lamot and et al. : Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study., Neurocritical Care, 40, 2, 515-528, 2023. (Summary) In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO₂) predicting in-hospital mortality. We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, subarachnoid aneurysmal hemorrhage, intracranial hemorrhage, ischemic stroke) with available data on PaO₂ during the ICU stay were included. Hypoxemia was defined as PaO₂ < 80 mm Hg, normoxemia was defined as PaO₂ between 80 and 120 mm Hg, mild/moderate hyperoxemia was defined as PaO₂ between 121 and 299 mm Hg, and severe hyperoxemia was defined as PaO₂ levels ≥ 300 mm Hg. A total of 1,407 patients were included in this study. The mean age was 52 (±18) years, and 929 (66%) were male. Over the ICU stay, the fractions of patients in the study cohort who had at least one episode of hypoxemia, mild/moderate hyperoxemia, and severe hyperoxemia were 31.3%, 53.0%, and 1.7%, respectively. PaO₂ values below 92 mm Hg and above 156 mm Hg were associated with an increased probability of in-hospital mortality. Differences were observed among subgroups of patients with ABI, with consistent effects only seen in patients without traumatic brain injury. In patients with ABI, hypoxemia and mild/moderate hyperoxemia were relatively frequent. Hypoxemia and hyperoxemia during ICU stay may influence in-hospital mortality. However, the small number of oxygen values collected represents a major limitation of the study. (Keyword) Adult / Humans / male / Middle Aged / female / Hyperoxia / Prospective Studies / Retrospective Studies / Hypoxia / Oxygen / Brain Injuries / Subarachnoid Hemorrhage / Brain Injuries, Traumatic / brain (Link to Publication Site) ● Publication site (DOI): 10.1007/s12028-023-01761-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37322325 ● Summary page in Scopus @ Elsevier: 2-s2.0-85161893586 (DOI: 10.1007/s12028-023-01761-x, PubMed: 37322325, Elsevier: Scopus)
16.	Sarah Wahlster, Monisha Sharma, Shaurya Taran, A. James Town, D. Robert Stevens, Raphaël Cinotti, Karim Asehoune, Paolo Pelosi, Chiara Robba, sélim Paër Abback, Anaïs Codorniu, Giuseppe Citerio, Ludovica Vittoria Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Giuseppina Jessica Maugeri, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Denise Battaglini, Patrick Biston, Fathi Mohamed Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter Vliet van, Marcel Benjamin Gerretsen, Xochitl Iris Ortiz-Macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, J. Wytze Vermeijden, Daniel Alexander Cornet, Reyes Sergio Inurrigarro, Lara Rafael Cirino Domínguez, Mercedes Maria Bellini, Milagros Haedo Maria Gomez, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronia, Carlos Roberto Miranda-Ackerman, José Francisco Barbosa-Camacho, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Compagnon, David Pérez-Torres, Estefanía Prol-Silva, Basheer Hana Yahya, Ala Khaled, Mohamed Ghula, Neville Cracchiolo Andrea, Maria Palma Daniela, Cristian Deana, Luigi Vetrugno, J.Rivera Manuel Chavez, Mendoza Rocio Trujillo, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu der Jagt van, Job Steenkiste van, Hazem Ahmed, Edward Alexander Coombs, Jessie Welbourne, Alicia Pineda Ana Velarde, Hugo Castillo Víctor Nubert, A. Mohammed Azab, Y. Ahmed Azzam, Paul Meenen David Michael van, Adrian Gilberto Gasca, Alfredo Arellano, Forttino Galicia-Espinosa, Carlos José García-Ramos, Ghanshyam Yadav, Kumar Amarendra Jha, Vincent Robert-Edan, Andre Pierre Rodie-Talbere, Gaurav Jain, Sagarika Panda, Sonika Agarwal, Yashbir Deewan, et al. and Yoshitoyo Ueno : Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial, Critical Care, 27, 1, 156, 2023. (Summary) There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale 12 before intubation) who required mechanical ventilation (MV) 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2-15.1], 13 J/min [IQR 10-17], and 14 J/min [IQR 11-20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14-1.30) and HD3 (1.38, 95% CI 1.23-1.53), reintubation on HD1 (1.64; 95% CI 1.57-1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18-1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56-2.78) and HD3 (1.76; 95% CI 1.41-2.22). Exposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation. (Keyword) Acute brain injury / Acute ischemic stroke / Acute respiratory distress syndrome / Intracranial hemorrhage / Mechanical power / Mechanical ventilation / Subarachnoid hemorrhage / Traumatic brain injury (Link to Publication Site) ● Publication site (DOI): 10.1186/s13054-023-04410-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37081474 ● Summary page in Scopus @ Elsevier: 2-s2.0-85153446135 (DOI: 10.1186/s13054-023-04410-z, PubMed: 37081474, Elsevier: Scopus)
17.	Hiroki TAKAI, Shodai YAMADA, Yoshihiro SUNADA, Yoshifumi TAO, Yukari MINAMI(OGAWA), Noriya Enomoto, Satoshi HIRAI, Kenji YAGI, Shunji MATSUBARA and Masaaki UNO : Surgical Approach to Remove a Central Venous Catheter Inserted into the Vertebral Artery: A Case Report, Surgery for Cerebral Stroke, 51, 3, 244-250, 2023. (Link to Publication Site) ● Publication site (DOI): 10.2335/scs.51.244 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390859293117292800 ● Search Scopus @ Elsevier (DOI): 10.2335/scs.51.244 (DOI: 10.2335/scs.51.244, CiNii: 1390859293117292800)
18.	Tomohiro Matsuda, Koichi Satoh, Takeshi Miyamoto, Noriya Enomoto, Mami Hanaoka, Hitoshi Niki and Kazuhito Matsuzaki : A case of ruptured dissecting posterior inferior cerebellar artery (PICA) aneurysm with double origin of the PICA avoiding ischemic complications, Japanese Journal of Stroke, 45, 6, 473-478, 2023. (Link to Publication Site) ● Publication site (DOI): 10.3995/jstroke.11145 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390861228319580800 ● Search Scopus @ Elsevier (DOI): 10.3995/jstroke.11145 (DOI: 10.3995/jstroke.11145, CiNii: 1390861228319580800)
19.	Raphaël Cinotti, Cesar Julio Mijangos, Paolo Pelosi, Matthias Haenggi, Mohan Gurjar, J. Marcus Schultz, Callum Kaye, Agustin Daniel Godoy, Pablo Alvarez, Aikaterini Ioakeimidou, Yoshitoyo Ueno, Rafael Badenes, Ali Elbuzidi Abdurrahmaan Suei, Michaël Piagnerelli, Muhammed Elhadi, Tariq Syed Reza, Atef Mohammed Azab, Victoria McCredie, D. Robert Stevens, Catherine Jean Digitale, Nicholas Fong, Karim Asehnoune, sélim Paër Abback, Anaïs Codorniu, Giuseppe Citerio, Ludovica Vittoria Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Giuseppina Jessica Maugeri, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Chiara Robba, Denise Battaglini, Patrick Biston, Fathi Mohamed Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter Vliet van, Marcel Benjamin Gerretsen, Xochitl Iris Ortiz-Macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, J. Wytze Vermeijden, Daniel Alexander Cornet, Reyes Sergio Inurrigarro, Lara Rafael Cirino Domínguez, Mercedes Maria Bellini, Gomez Maria Milagros Haedo, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronia, Carlos Roberto Miranda-Ackerman, José Francisco Barbosa-Camacho, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Compagnon, David Pérez-Torres, Estefanía Prol-Silva, Basheer Hana Yahya, Ala Khaled, Mohamed Ghula, Neville Cracchiolo Andrea, Maria Palma Daniela, Cristian Deana, Luigi Vetrugno, J.Rivera Manuel Chavez, Mendoza Rocio Trujillo, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu der Jagt van, Job Steenkiste van, Hazem Ahmed, Edward Alexander Coombs, Jessie Welbourne, Velarde Ana Alicia Pineda, Nubert Víctor Hugo Castillo and Atef Mohammed Azab : Extubation in neurocritical care patients: the ENIO international prospective study, Intensive Care Medicine, 48, 11, 1539-1550, 2022. (Summary) Neurocritical care patients receive prolonged invasive mechanical ventilation (IMV), but there is poor specific information in this high-risk population about the liberation strategies of invasive mechanical ventilation. ENIO (NCT03400904) is an international, prospective observational study, in 73 intensive care units (ICUs) in 18 countries from 2018 to 2020. Neurocritical care patients with a Glasgow Coma Score (GCS) ≤ 12, receiving IMV ≥ 24 h, undergoing extubation attempt or tracheostomy were included. The primary endpoint was extubation failure by day 5. An extubation success prediction score was created, with 2/3 of patients randomly allocated to the training cohort and 1/3 to the validation cohort. Secondary endpoints were the duration of IMV and in-ICU mortality. 1512 patients were included. Among the 1193 (78.9%) patients who underwent an extubation attempt, 231 (19.4%) failures were recorded. The score for successful extubation prediction retained 20 variables as independent predictors. The area under the curve (AUC) in the training cohort was 0.79 95% confidence interval (CI₉₅) [0.71-0.87] and 0.71 CI₉₅ [0.61-0.81] in the validation cohort. Patients with extubation failure displayed a longer IMV duration (14 [7-21] vs 6 [3-11] days) and a higher in-ICU mortality rate (8.7% vs 2.4%). Three hundred and nineteen (21.1%) patients underwent tracheostomy without extubation attempt. Patients with direct tracheostomy displayed a longer duration of IMV and higher in-ICU mortality than patients with an extubation attempt (success and failure). In neurocritical care patients, extubation failure is high and is associated with unfavourable outcomes. A score could predict extubation success in multiple settings. However, it will be mandatory to validate our findings in another prospective independent cohort. (Keyword) Brain injury / Extubation / Intra-cranial haemorrhage / Tracheostomy / Traumatic brain injury (Link to Publication Site) ● Publication site (DOI): 10.1007/s00134-022-06825-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36038713 ● Summary page in Scopus @ Elsevier: 2-s2.0-85136883213 (DOI: 10.1007/s00134-022-06825-8, PubMed: 36038713, Elsevier: Scopus)
20.	Masaaki Korai, Noriya Enomoto, Koichi Satoh, Shunji Matsubara, Yasuhisa Kanematsu, Tadashi Yamaguchi, Mami Hanaoka, Hitoshi Niki, Kazuhito Matsuzaki, Koji Bando, Hirotaka Hagino and Yasushi Takagi : Transarterial embolization for convexity dural arteriovenous fistula with or without pial arterial supply: A report of four patients, Surgical Neurology International, 13, 340, 1-6, 2022. (Tokushima University Institutional Repository) ● Metadata: 2010695 (Link to Publication Site) ● Publication site (DOI): 10.25259/SNI_215_2022 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85136192478 (Tokushima University Institutional Repository: 2010695, DOI: 10.25259/SNI_215_2022, Elsevier: Scopus)
21.	Shunji Matsubara, Hiroki Takai, Noriya Enomoto, Keijiro Hara, Satoshi Hirai, Yoshihiro Sunada, Shodai Yamada, Yoshifumi Tao, Yukari Ogawa, Kenji Yagi and Masaaki Uno : Anterior cranial fossa osseous arteriovenous fistula of the crista galli with bone erosion: patient series, Journal of Neurosurgery. Case Lessons, 3, 19, 2022. (Link to Publication Site) ● Publication site (DOI): 10.3171/case2243 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1872273591437159296 ● Summary page in Scopus @ Elsevier: 2-s2.0-85160529949 (DOI: 10.3171/case2243, CiNii: 1872273591437159296, Elsevier: Scopus)
22.	Kiyohito Shinno, Noriya Enomoto, Kenji Shono, Tetsuya Tamura and Yuya Watari : Traumatic carotid artery occlusion complicated by cerebral infarction: A report of three cases, Neurotraumatology, 44, 2, 60-65, 2021. (Link to Publication Site) ● Publication site (DOI): 10.32187/neurotraumatology.44.2_60 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390008998107765248 ● Search Scopus @ Elsevier (DOI): 10.32187/neurotraumatology.44.2_60 (DOI: 10.32187/neurotraumatology.44.2_60, CiNii: 1390008998107765248)
23.	Noriya Enomoto, Kenji Yagi, Shunji Matsubara and Masaaki Uno : Case Report: Bow Hunter's Syndrome Caused by Compression of Extracranially Originated Posterior Inferior Cerebellar Artery., Frontiers in Neurology, 12, 2021. (Summary) Bow hunter's syndrome (BHS) is most commonly caused by compression of the vertebral artery (VA). It has not been known to occur due to an extracranially originated posterior inferior cerebellar artery (PICA), the first case of which we present herein. A 71-year-old man presented with reproducible dizziness on leftward head rotation, indicative of BHS. On radiographic examination, the bilateral VAs merged into the basilar artery, and the left VA was predominant. The right PICA originated extracranially from the right VA at the atlas-axis level and ran vertically into the spinal canal. During the head rotation that induced dizziness, the right PICA was occluded, and a VA stenosis was revealed. Occlusion of the PICA was considered to be the primary cause of the dizziness. The patient underwent surgery to decompress the right PICA and VA via a posterior cervical approach. Following surgery, the patient's dizziness disappeared, and the stenotic change at the right VA and PICA improved. The PICA could be a causative artery for BHS when it originates extracranially at the atlas-axis level, and posterior decompression is an effective way to treat it. (Link to Publication Site) ● Publication site (DOI): 10.3389/fneur.2021.756838 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34764931 ● Summary page in Scopus @ Elsevier: 2-s2.0-85118766873 (DOI: 10.3389/fneur.2021.756838, PubMed: 34764931, Elsevier: Scopus)
24.	Shunji Matsubara, Hiroyuki Toi, Hiroki Takai, Yuko Miyazaki, Keita Kinoshita, Yoshihiro Sunada, Shodai Yamada, Yoshifumi Tao, Noriya Enomoto, Ogawa Yukari Minami, Satoshi Hirai, Kenji Yagi, Hiroyuki Nakashima and Masaaki Uno : Variations and management for patients with craniocervical junction arteriovenous fistulas: Comparison of dural, radicular, and epidural arteriovenous fistulas., Surgical Neurology International, 12, 2021. (Summary) Craniocervical junction arteriovenous fistulas (CCJAVFs) are known to be rare, but variations and clinical behaviors remain controversial.A total of 11 CCJAVF patients (M: F=9:2, age 54-77 years) were investigated. Based on the radiological and intraoperative findings, they were categorized into three types: dural AVF (DAVF), radicular AVF (RAVF), and epidural AVF (EDAVF).There were four symptomatic patients (subarachnoid hemorrhage in two, myelopathy in one, and tinnitus in one) and seven asymptomatic patients in whom coincidental CCJAVFs were discovered on imaging studies for other vascular diseases (arteriovenous malformation in one, intracranial DAVF in two, ruptured cerebral aneurysm in two, and carotid artery stenosis in two). Of these 11 patients, 2 (18.2%) had multiple CCJAVFs. Of 14 lesions, the diagnoses were DAVF in 5, RAVF in 3, and EDAVF in 6 (C1-C2 level ratio =5:0, 2:1, 3:3). Patients with DAVF/RAVF in four lesions with intradural venous reflux underwent surgery, although an RAVF remained in one lesion after embolization/radiation. Since all six EDAVFs, two DAVFs, and one RAVF had neither feeder aneurysms nor significant symptoms, no treatment was provided; of these nine lesions, one DAVF and one RAVF remained unchanged, whereas six EDAVFs showed spontaneous obliteration within a year. Unfortunately, however, one DAVF bled before elective surgery.CCJAVFs have many variations of shunting site, angioarchitecture, and multiplicity, and they were frequently associated with coincidental vascular lesions. For symptomatic DAVF/RAVF lesions with intradural drainage, surgery is preferred, whereas asymptomatic EDAVFs without dangerous drainage may obliterate during their natural course. (Link to Publication Site) ● Publication site (DOI): 10.25259/SNI_557_2021 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34513175 ● Summary page in Scopus @ Elsevier: 2-s2.0-85113667866 (DOI: 10.25259/SNI_557_2021, PubMed: 34513175, Elsevier: Scopus)
25.	Noriya Enomoto, Kiyohito Shinno, Tetsuya Tamura, Eiji Shikata, Kenji Shono and Kensaku Takase : Ruptured Basilar Artery Perforator Aneurysm: A Case Report and Review of the Literature., NMC Case Report Journal, 7, 3, 93-100, 2020. (Summary) Basilar artery perforator aneurysms (BAPAs) are a rare cause of subarachnoid hemorrhage (SAH), and the natural history is still unknown. Herein, we report a case of ruptured BAPA that appeared during the observation period and then spontaneously disappeared; we have also conducted a review of the literature and performed an analysis based on the type of management. This case of BAPA had a unique course, and our observations may help establish a treatment strategy. A 60-year-old man presented with acute diffuse SAH, World Federation of Neurosurgical Societies (WFNS) Grade II and Fisher Grade 3. Initial three-dimensional digital subtraction angiography (DSA) did not show the source of the hemorrhage. DSA performed on day 39 showed a BAPA with a diameter of 3 mm at the posterior surface of the upper third of the basilar artery. Conservative treatment was chosen. DSA performed on day 64 showed complete resolution of the aneurysm. BAPAs are likely pseudoaneurysms, and not saccular aneurysms, caused due to dissection of basilar perforator arteries. BAPAs are often not recognized on initial imaging, and hence, it is necessary to repeat the DSA examination. Considering the relatively high rate of spontaneous resolution, we chose conservative management. When BAPAs enlarge or do not disappear after conservative treatment, additional therapy such as multiple stents should be considered. (Link to Publication Site) ● Publication site (DOI): 10.2176/nmccrj.cr.2019-0143 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32695555 ● Search Scopus @ Elsevier (PMID): 32695555 ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2019-0143 (DOI: 10.2176/nmccrj.cr.2019-0143, PubMed: 32695555)
26.	Hideo Mure, Noriya Enomoto, Toshiyuki Okazaki, Shinya Okita and Shinji Nagahiro : A Case of Cerebrospinal Fluid Leak Associated with a Meningeal Diverticulum at the C2 Root Sleeve, Spinal Surgery, 33, 1, 85-87, 2019. (Link to Publication Site) ● Publication site (DOI): 10.2531/spinalsurg.33.85 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282763116916480 ● Search Scopus @ Elsevier (DOI): 10.2531/spinalsurg.33.85 (DOI: 10.2531/spinalsurg.33.85, CiNii: 1390282763116916480)
27.	Noriya Enomoto, Hideo Mure, Toshiyuki Okazaki, Mai Azumi, S Okita, Shinji Nagahiro and Yasushi Takagi : Posttraumatic Cerebrospinal Fluid Leak Associated with an Upper Cervical Meningeal Diverticulum, World Neurosurgery, 116, 50-55, 2018. (Summary) Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis remains unclear. We report 2 cases of SIH resulting from CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who experienced orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1-2 level. He underwent epidural blood patch therapy, but it was unsuccessful. Next, we performed direct surgery and found a meningeal diverticulum originating from the left C2 nerve root; therefore, we ligated the diverticulum. His symptoms and image findings strikingly improved after surgery. The second case is that of a 45-year-old man who experienced orthostatic headache 1 month after jumping into a river. Magnetic resonance imaging of the head showed bilateral subdural hematoma. CT myelography revealed CSF leaks at the C1-2 level and multiple cyst formations at the cervical and thoracic nerve root sleeves. epidural blood patch was performed, and his symptoms immediately improved. Recent studies have reported that meningeal diverticulum is involved in various cases of CSF leaks. The 2 cases indicate that traumatic accidents, such as back-and-forth neck movement or falls, presumably induce an increase in CSF pressure, followed by the rupture of an existing meningeal diverticulum, leading to CSF leak. (Keyword) Blood Patch, Epidural / Brain Injuries, Traumatic / Cerebrospinal Fluid Leak / Cervical Vertebrae / Diverticulum / Humans / Male / Meninges / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.1016/j.wneu.2018.05.061 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29777885 ● Summary page in Scopus @ Elsevier: 2-s2.0-85047768412 (DOI: 10.1016/j.wneu.2018.05.061, PubMed: 29777885, Elsevier: Scopus)

Academic Letter:

1.	Hugues Courson de, Nicolas Massart, Karim Asehnoune, Raphaël Cinotti, sélim Paër Abback, Anaïs Codorniu, Giuseppe Citerio, Ludovica Vittoria Sala, Marinella Astuto, Eleonora Tringali, Daniela Alampi, Monica Rocco, Giuseppina Jessica Maugeri, Agrippino Bellissima, Matteo Filippini, Nicoletta Lazzeri, Andrea Cortegiani, Mariachiara Ippolito, Chiara Robba, Denise Battaglini, Patrick Biston, Fathi Mohamed Al-Gharyani, Russell Chabanne, Léo Astier, Benjamin Soyer, Samuel Gaugain, Alice Zimmerli, Urs Pietsch, Miodrag Filipovic, Giovanna Brandi, Giulio Bicciato, Ainhoa Serrano, Berta Monleon, Peter Vliet van, Marcel Benjamin Gerretsen, Xochitl Iris Ortiz-Macias, Jun Oto, Noriya Enomoto, Tomomichi Matsuda, Nobutaka Masui, Pierre Garçon, Jonathan Zarka, J. Wytze Vermeijden, Daniel Alexander Cornet, Reyes Sergio Inurrigarro, Lara Rafael Cirino Domínguez, Mercedes Maria Bellini, Gomez Maria Milagros Haedo, Laura Lamot, Jose Orquera, Matthieu Biais, Delphine Georges, Arvind Baronia, Carlos Roberto Miranda-Ackerman, José Francisco Barbosa-Camacho, John Porter, Miguel Lopez-Morales, Thomas Geeraerts, Baptiste Compagnon, David Pérez-Torres, Estefanía Prol-Silva, Basheer Hana Yahya, Ala Khaled, Mohamed Ghula, Neville Cracchiolo Andrea, Maria Palma Daniela, Cristian Deana, Luigi Vetrugno, J.Rivera Manuel Chavez, Mendoza Rocio Trujillo, Vincent Legros, Benjamin Brochet, Olivier Huet, Marie Geslain, Mathieu der Jagt van, Job Steenkiste van, Hazem Ahmed, Edward Alexander Coombs, Jessie Welbourne, Velarde Ana Alicia Pineda, Nubert Víctor Hugo Castillo, A. Mohammed Azab, Y. Ahmed Azzam, Paul Meenen David Michael van, Adrian Gilberto Gasca, Alfredo Arellano, Forttino Galicia-Espino-sa, Carlos José García-Ramos, Ghanshyam Yadav, Kumar Amarendra Jha, Vincent Robert-Edan, Andre Pierre Rodie-Talbere, Gaurav Jain, Sagarika Panda, Sonika Agarwal, Yashbir Deewan, Adrian Gilberto Gasca, Alfredo Arellano, Tariq Syed Reza, Mozaffer Md Hossain, Yoshitoyo Ueno and al. et : Risk factors of extubation failure in neurocritical patients with the most impaired consciousness, Intensive Care Medicine, 49, 10, 1251-1253, 2023. (Keyword) Humans / Airway Extubation / consciousness / Ventilator Weaning / Risk Factors / Respiration, Artificial / Treatment Failure (Link to Publication Site) ● Publication site (DOI): 10.1007/s00134-023-07189-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37610483 ● Summary page in Scopus @ Elsevier: 2-s2.0-85169078966 (DOI: 10.1007/s00134-023-07189-3, PubMed: 37610483, Elsevier: Scopus)

Proceeding of International Conference:

1.	Kenji Shimada, Izumi Yamaguchi, Takeshi Miyamoto, Masaaki Korai, Hiroshi Koyama, Noriya Enomoto, Shimabuku Alfredo, Kitazato T. Keiko and Yasushi Takagi : Inflammation-Mediated Changes in Caspase-8 and MLKL/RIPK3 Expression Profiles in Cerebral Arteriovenous Malformations Associated With Hemorrhage, 6th World AVM Congress & SNVIS Annual Scientific Meeting 2026, Mar. 2026.
2.	Noriya Enomoto, Takeshi Miyamoto, Hiroshi Koyama, Izumi Yamaguchi, Masaaki Korai, Yoshiteru Tada, Kenji Shimada, Kitazato T. Keiko and Yasushi Takagi : Lipopolysaccharide from periodontal bacteria inuences the incidence of subarachnoid hemorrhage, The 11th Joint Neurosurgical Convention, Feb. 2026.
3.	Noriya Enomoto, Takeshi Miyamoto, Hiroshi Koyama, Masaaki Korai, Yoshiteru Tada, Kenji Shimada, Kitazato Keiko and Yasushi Takagi : Lipopolysaccharide of periodontal bacteria influences the incidence of subarachnoid hemorrhage, Brain & Brain PET 2025, Seoul, Jun. 2025.
4.	Masaaki Korai, Noriya Enomoto, Takeshi Miyamoto, Kenji Shimada and Yasushi Takagi : Basic technique of carotid endarterectomy with patch graft and long- term outcomes at 10 and 15 years postoperatively, Brain & Brain PET 2025, Seoul, Jun. 2025.

Proceeding of Domestic Conference:

1.	KASHIOKA Fujiko, Noriya Enomoto, Takeshi Miyamoto, Izumi Yamaguchi, Masaaki Korai, Yoshiteru Tada, Kenji Shimada, 北里慶子 and Yasushi Takagi : ⻭周病菌由来リポ多糖が脳動脈瘤モデルラットに与える影響, STROKE2026, Mar. 2026.
2.	KASHIOKA Fujiko, Noriya Enomoto, Takeshi Miyamoto, Hiroshi Koyama, Masaaki Korai, Yoshiteru Tada, Kenji Shimada, 北里慶子 and Yasushi Takagi : 歯周病菌由来リポ多糖は脳動脈瘤モデルラットにおいてくも膜下出血の発症を促進する, 日本脳神経外科学会第84回学術総会, Oct. 2025.
3.	Noriya Enomoto, Takeshi Miyamoto, Hiroshi Koyama, Hiroshi Kagusa, Izumi Yamaguchi, Masaaki Korai, Yoshiteru Tada, Kenji Shimada, 北里慶子 and Yasushi Takagi : ⻭周病菌由来リポ多糖は脳動脈瘤モデルラットにおいてくも膜下出⾎の発症に影響する, 第68回日本脳循環代謝学会学術集会, Oct. 2025.
4.	Hiroshi Kagusa, Keijiro Hara, Kohhei Nakajima, Hiroshi Koyama, Noriya Enomoto, 北里慶子, Yasuhisa Kanematsu and Yasushi Takagi : 外傷性脳内微小出血模倣モデルマウスの認知行動解析と認知症蛋白蓄積機序や制御の検討, 第68回日本脳循環代謝学会学術集会, Oct. 2025.
5.	Takeshi Miyamoto, Noriya Enomoto, 松田知大, Natsumi Teshima, 佐藤裕一, KAGEYAMA Ayato, Tadashi Yamaguchi, Masaaki Korai, Yoshitaka Kurashiki, Kenji Shimada, 花岡真実, 仁木均, Kazuhito Matsuzaki, Koichi Satoh and Yasushi Takagi : 9Fr Balloon Guiding Catheterと6Fr Guiding Sheathを用いた血栓回収術の比較検討, 第1回日本脳神経外科M&M学会, Jul. 2025.
6.	Masaaki Korai, Toshiyuki Okazaki, Yasuhisa Kanematsu, Noriya Enomoto, Takeshi Miyamoto, Kenji Shimada and Yasushi Takagi : Patch graftを用いたCEAの基本手技と術後10年，15年の長期成績, STROKE2025, Mar. 2025.
7.	Masaaki Korai, Noriya Enomoto, HABOSHI Tatsuya, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, KURODA Kazutaka, Nobuaki Yamamoto, Yasuhisa Kanematsu, Shunji Matsubara, Koichi Satoh and Yasushi Takagi : Incidence and temporal angiographic changes in venous drainage of convexity dural arteriovenous fistula, STROKE 2024, Mar. 2024.
8.	Masaaki Korai, Noriya Enomoto, Izumi Yamaguchi, Shu Sogabe, Kenji Shimada, Kazutaka KURODA, Nobuaki Yamamoto, Yasuhisa Kanematsu, Shunji Matsubara, Koichi Satoh and Yasushi Takagi : Incidence and temporal angiographic changes in venous drainage of convexity dural arteriovenous fistula, 第39回日本脳神経血管内治療学会学術集会, Nov. 2023.
9.	Hideo Mure, Noriya Enomoto, Shinya Ohkita and Shinji Nagahiro : C2神経根起始部に髄膜憩室を認めた脳脊髄液漏出症の一例, 第32回日本脊髄外科学会, Jun. 2017.
10.	Kohhei Nakajima, Noriya Enomoto, Mai Azumi, Shinya Ohkita, Yoshifumi Mizobuchi and Shinji Nagahiro : 脳脊髄液中に好酸球増多を認めたシャント機能不全の1例, 第45回日本小児神経外科学会, Jun. 2017.
11.	Noriya Enomoto, Hideo Mure, Shinya Ohkita, Junichiro Satomi and Shinji Nagahiro : C2神経根起始部にmeningeal diverticulium を認めた脳脊髄駅漏出症の1例, 第82回日本脳神経外科学会中四国支部学術集会, Dec. 2016.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

脳動静脈奇形の血中exosome解析による病態と破裂機序解明に関する検討 (Project/Area Number: 25K12341 )
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Designated Assistant Professor : Enomoto, Noriya

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)