Tokushima University / Educator and Researcher Directory --- Nishida, Mari

Search:

Tokushima University ⟩ University Hospital ⟩ Central Clinical Facilities ⟩ Oral Health Management Center ⟩

(Files for researchmap) [PDF manual] [Auto-propagate to researchmap]

Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Mari Nishida, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Aya Ushio, Takaaki Tsunematsu, Keiko Aota and Naozumi Ishimaru : Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease., Journal of Immunology Research, 2026, 1, 2026. (Summary) Sjögren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development. However, the mechanisms linking age and disease progression remain poorly understood. Age-associated B cells (ABCs), a subset of B cells that increase with age, have been implicated in autoimmune responses, but their role in SjD pathogenesis has not been fully clarified. In this study, we examined labial salivary glands (LSGs) from 44 SjD patients and 11 non-SjD sicca controls. T-bet+ CD20+ ABCs were detected infiltrating the glands in SjD patients, especially in individuals in their 40s-60s, but were rare in non-SjD sicca controls. To investigate the underlying mechanisms, we used a SjD mouse model at various ages. ABCs (CD11b+ CD95+ CD19+) began locally accumulating in the SGs from the mature-adult stage, earlier than in age-matched controls, while remaining low in cervical lymph nodes (cLNs). To explore the drivers of ABC expansion, we examined the factors involved in ABC differentiation, focusing on interleukin-21 (IL-21) and interferon-gamma (IFN-γ). This combination of IL-21 and IFN-γ upregulated T-bet expression on B cells in SjD model mice. In situ hybridization (ISH) and flow cytometric analysis revealed that CD4+ T cells, especially follicular helper T (Tfh)-like cells were a major source of IL-21 in the SGs of mature-adult-SjD mice. Additionally, ABCs themselves showed elevated expression of IFN-γ compared to other immune cells, indicating an autocrine mechanism promoting their expansion. Our findings suggest that ABCs accumulate in the SGs of SjD patients and model mice through IL-21 signaling from CD4+ T cells and autocrine IFN-γ activity. This localized expansion may contribute to autoimmune tissue damage. These results provide new insights into how aging-associated immune changes may drive the development and progression of SjD, offering potential targets for therapeutic intervention. (Keyword) Sjogren's Syndrome / Interleukin-21 / Animals / Interleukins / Humans / Mice / Interferon-gamma / salivary glands / B-Lymphocytes / female / Middle Aged / Adult / Disease Models, Animal / aging / Aged (Tokushima University Institutional Repository) ● Metadata: 2014225 (Link to Publication Site) ● Publication site (DOI): 10.1155/jimr/4221251 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41873888 ● Search Scopus @ Elsevier (PMID): 41873888 ● Search Scopus @ Elsevier (DOI): 10.1155/jimr/4221251 (Tokushima University Institutional Repository: 2014225, DOI: 10.1155/jimr/4221251, PubMed: 41873888)

Proceeding of International Conference:

1.	Keiko Aota, Hiroaki Tawara, Mari Nishida, Shinji Ono, Hiroaki Hochi, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Daisuke Hinode and Fumihiko Tsushima : Effect of Perioperative Oral Management on Postoperative Pneumonia: A 16-Year Longitudinal and Department-Specific Analysis, The 6th Annual Meeting of the International Society of Oral Care, Matsumoto, May 2026.

Proceeding of Domestic Conference:

1.	Kohichi Kani, Keiko Aota, 高岡由実, 大山博行, Mari Nishida, Hiroaki Hochi, Kohei Naniwa, Yukihiro Momota and Fumihiko Tsushima : 当科外来抜歯におけるSSI予防抗菌薬適正使用の現状, 第55回日本口腔外科学会中国四国支部学術集会, May 2026.
2.	Keiko Aota, Kohei Naniwa, Hiroaki Tawara, Mari Nishida, Shinji Ono, Hiroaki Hochi, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Daisuke Hinode and Fumihiko Tsushima : 周術期等口腔機能管理の導入拡充が全身麻酔術後肺炎に及ぼす影響:経年変化と診療科別比較による検討, 第23回日本口腔ケア学会総会学術大会, May 2026.
3.	Kohichi Kani, Keiko Aota, 高岡由実, Mari Nishida, Hiroaki Hochi, 大山博行, Kohei Naniwa, Yukihiro Momota and Fumihiko Tsushima : 裏装上皮に異形成がみられた発育性歯原性嚢胞の1例, 第80回NPO法人日本口腔科学会学術集会, Apr. 2026.
4.	Mari Nishida, Kunihiro Otsuka, Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota, Takaaki Tsunematsu, Naozumi Ishimaru and Keiko Aota : 老化関連B細胞を介したシェーグレン症候群における病態形成機構．, 第70回日本口腔外科会学会総会・学術集会, Nov. 2025.
5.	Hiroaki Hochi, Keiko Aota, Mari Nishida, 大山博行, Hiroaki Tawara, Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota and Fumihiko Tsushima : 口腔症状を契機に診断に至った多発性内分泌腫瘍症2B型(MEN2B)の1例, 第70回日本口腔外科学会総会・学術大会, Nov. 2025.
6.	高岡由実, Kohei Naniwa, Mami Sato-Fukuba, Mari Nishida, 大山博行, Hiroaki Hochi, Hiroaki Tawara, Kohichi Kani, Yukihiro Momota and Keiko Aota : 唾液腺実質障害を伴わない口腔乾燥症の臨床的特徴と関連因子の検討, 第72回日本口腔科学会中国四国部会, Oct. 2025.
7.	大山博行, Mari Nishida, Hiroaki Hochi, Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota and Keiko Aota : テリパラチドが有効であった薬剤関連顎骨壊死の1例, 第54回日本口腔外科学会中国四国支部学術集会, Apr. 2025.

Et cetera, Workshop:

1.	Kohei Naniwa, Hiroaki Tawara, 高岡由実, Mari Nishida, 金川裕子, Hiroaki Hochi, 大山博行, Mami Sato-Fukuba, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Keizo Wada, Koichi Sairyo and Keiko Aota : 整形外科インプラント手術における周術期等口腔機能管理の有効性の検討, 第270回徳島医学会学術集会, Jul. 2025.