徳島大学 / 教育研究者総覧 --- 西田真理

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徳島大学 ⟩ 病院 ⟩ 中央診療施設等 ⟩ 口腔管理センター ⟩

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著書・論文

学術論文(審査論文):

1.	Mari Nishida, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Aya Ushio, Takaaki Tsunematsu, Keiko Aota and Naozumi Ishimaru : Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease., Journal of Immunology Research, 2026, 1, 2026. (要約) Sjögren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development. However, the mechanisms linking age and disease progression remain poorly understood. Age-associated B cells (ABCs), a subset of B cells that increase with age, have been implicated in autoimmune responses, but their role in SjD pathogenesis has not been fully clarified. In this study, we examined labial salivary glands (LSGs) from 44 SjD patients and 11 non-SjD sicca controls. T-bet+ CD20+ ABCs were detected infiltrating the glands in SjD patients, especially in individuals in their 40s-60s, but were rare in non-SjD sicca controls. To investigate the underlying mechanisms, we used a SjD mouse model at various ages. ABCs (CD11b+ CD95+ CD19+) began locally accumulating in the SGs from the mature-adult stage, earlier than in age-matched controls, while remaining low in cervical lymph nodes (cLNs). To explore the drivers of ABC expansion, we examined the factors involved in ABC differentiation, focusing on interleukin-21 (IL-21) and interferon-gamma (IFN-γ). This combination of IL-21 and IFN-γ upregulated T-bet expression on B cells in SjD model mice. In situ hybridization (ISH) and flow cytometric analysis revealed that CD4+ T cells, especially follicular helper T (Tfh)-like cells were a major source of IL-21 in the SGs of mature-adult-SjD mice. Additionally, ABCs themselves showed elevated expression of IFN-γ compared to other immune cells, indicating an autocrine mechanism promoting their expansion. Our findings suggest that ABCs accumulate in the SGs of SjD patients and model mice through IL-21 signaling from CD4+ T cells and autocrine IFN-γ activity. This localized expansion may contribute to autoimmune tissue damage. These results provide new insights into how aging-associated immune changes may drive the development and progression of SjD, offering potential targets for therapeutic intervention. (キーワード) Sjogren's Syndrome / Interleukin-21 / Animals / Interleukins / Humans / Mice / Interferon-gamma / 唾液腺 (salivary glands) / B-Lymphocytes / 女性 (female) / Middle Aged / Adult / Disease Models, Animal / 加齢 (aging) / Aged (徳島大学機関リポジトリ) ● Metadata: 2014225 (出版サイトへのリンク) ● Publication site (DOI): 10.1155/jimr/4221251 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41873888 ● Search Scopus @ Elsevier (PMID): 41873888 ● Search Scopus @ Elsevier (DOI): 10.1155/jimr/4221251 (徳島大学機関リポジトリ: 2014225, DOI: 10.1155/jimr/4221251, PubMed: 41873888)

国際会議:

1.	Keiko Aota, Hiroaki Tawara, Mari Nishida, Shinji Ono, Hiroaki Hochi, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Daisuke Hinode and Fumihiko Tsushima : Effect of Perioperative Oral Management on Postoperative Pneumonia: A 16-Year Longitudinal and Department-Specific Analysis, The 6th Annual Meeting of the International Society of Oral Care, Matsumoto, May 2026.

国内講演発表:

1.	可児耕一, 青田桂子, 高岡由実, 大山博行, 西田真理, 芳地浩彰, 浪花耕平, 桃田幸弘, 津島文彦 : 当科外来抜歯におけるSSI予防抗菌薬適正使用の現状, 第55回日本口腔外科学会中国四国支部学術集会, 2026年5月.
2.	青田桂子, 浪花耕平, 俵宏彰, 西田真理, 小野信二, 芳地浩彰, 可児耕一, 桃田幸弘, 福井誠, 日野出大輔, 津島文彦 : 周術期等口腔機能管理の導入拡充が全身麻酔術後肺炎に及ぼす影響:経年変化と診療科別比較による検討, 第23回日本口腔ケア学会総会学術大会, 2026年5月.
3.	可児耕一, 青田桂子, 高岡由実, 西田真理, 芳地浩彰, 大山博行, 浪花耕平, 桃田幸弘, 津島文彦 : 裏装上皮に異形成がみられた発育性歯原性嚢胞の1例, 第80回NPO法人日本口腔科学会学術集会, 2026年4月.
4.	西田真理, 大塚邦紘, 福場真美, 浪花耕平, 可児耕一, 桃田幸弘, 常松貴明, 石丸直澄, 青田桂子 : 老化関連B細胞を介したシェーグレン症候群における病態形成機構．, 第70回日本口腔外科会学会総会・学術集会, 2025年11月.
5.	芳地浩彰, 青田桂子, 西田真理, 大山博行, 俵宏彰, 福場真美, 浪花耕平, 可児耕一, 桃田幸弘, 津島文彦 : 口腔症状を契機に診断に至った多発性内分泌腫瘍症2B型(MEN2B)の1例, 第70回日本口腔外科学会総会・学術大会, 2025年11月.
6.	高岡由実, 浪花耕平, 福場真美, 西田真理, 大山博行, 芳地浩彰, 俵宏彰, 可児耕一, 桃田幸弘, 青田桂子 : 唾液腺実質障害を伴わない口腔乾燥症の臨床的特徴と関連因子の検討, 第72回日本口腔科学会中国四国部会, 2025年10月.
7.	大山博行, 西田真理, 芳地浩彰, 福場真美, 浪花耕平, 可児耕一, 桃田幸弘, 青田桂子 : テリパラチドが有効であった薬剤関連顎骨壊死の1例, 第54回日本口腔外科学会中国四国支部学術集会, 2025年4月.

その他・研究会:

1.	浪花耕平, 俵宏彰, 高岡由実, 西田真理, 金川裕子, 芳地浩彰, 大山博行, 福場真美, 可児耕一, 桃田幸弘, 福井誠, 和田佳三, 西良浩一, 青田桂子 : 整形外科インプラント手術における周術期等口腔機能管理の有効性の検討, 第270回徳島医学会学術集会, 2025年7月.