Tokushima University / Educator and Researcher Directory --- Miyoshi, Hirokazu

Personal Web Page

https://www.arremc.tokushima-u.ac.jp/Tema/miyoshi2024.html

https://researchmap.jp/read0081483 (researchmap)

Field of Study

○	Radiation Chemistry
○	Nanomaterials
○	Radiation Safety Management

Subject of Study

○	シリカナノ粒子のネットワーク構造化とその放射線効果に関する研究 (シリカナノ粒子) (シリカナノ粒子は，粒子サイズがナノメーターサイズになると，放射線照射によって，電子を放出するようになる．この電子の濃度を大きくするために，粒子を保ちながら，高濃度にパッキングする必要がある．このように高密度にパッキングする方法ならびにその放射線照射効果について研究している．)
○	機能性分子を固定したシリカナノ粒子に関する研究 (·)
○	教育訓練並びにRI施設における安全管理に関する研究

Book / Paper

Book:

1.	佐治英郎, 前田稔, 小島周二, 向高広, Hirokazu Miyoshi, 加留部善晴, 岩田錬, 月本光俊, 荒野泰, 間賀田泰寛, 工藤なをみ, 光本篤史, 川井恵一, 奥直人, 大桃善朗 and 金子実 : 新放射化学・放射性医薬品学改訂第4版, Nankodo, Tokyo, Aug. 2016.
2.	野口邦和, 伊藤伸彦, 白石久二雄, Hirokazu Miyoshi, 菅谷昭, 山口英昌 and 河岸宏和 : 放射能汚染食品，これが専門家8人の食べ方，選び方, 東洋経済新報社, Oct. 2011.
3.	前田稔, 黒田良孝, 畑野研一郎, Hirokazu Miyoshi, 加留部義晴, 岩田錬, 荒野秦, 工藤なをみ, 光本篤史, 川井恵一, 奥直人, 佐治英郎, 大桃善郎, 間賀田泰寛, 小島周二 and 金子実 : 新放射化学・放射性薬品学改訂第3版, Nankodo, Sep. 2011.
4.	前田稔, 畑野研一郎, Yoshinobu Baba, Hirokazu Miyoshi, 久保寺昭子, 加留部善晴, 鈴木和年, 荒野泰, 小川尚武, 小宮和英, 川井恵一, 福岡正道, 奥直人, 佐治英郎, 大桃善郎, 間賀田泰寛, 小島周二 and 金子実 : 新放射化学·放射性医薬品学, Nankodo, Jan. 2003.

Academic Paper (Judged Full Paper):

1.	Hirokazu Miyoshi and Masahiro Fujiwara : Efficient Separation of Tritiated Water from Light Water Based on Membrane Distillation by GasLiquid Exchange, ACS Sustainable Resource Management, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1021/acssusresmgt.4c00305 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1021/acssusresmgt.4c00305 (DOI: 10.1021/acssusresmgt.4c00305)
2.	Hirokazu Miyoshi, Mami Nakamura, Elizabeth M. Tsekrekas and Luiz G. Jacobsohn : Paper Scintillator Incorporated with ScintillatorSilica Fine Powders: Photophysical Characterization and Proof of Concept Demonstration of Tritium Detection, ACS Omega, Vol.9, No.28, 30470-30477, 2024. (Summary) In order to decrease the generation of radioactive waste, it is of interest to develop a scintillator capable of absorbing tritiated solutions for efficient detection of low-energy β-particles from tritium. In this work, paper scintillator incorporated with scintillator-silica fine powders (FPs), which is composed of scintillator-silica nanoparticles (NPs) attached to silica FP, was fabricated and evaluated. The scintillator-silica NPs contained liquid scintillators benzoic acid, 2,5-diphenyloxazole (PPO), and 1,4-bis(5-phenyloxazol-2-yl) benzene (POPOP). Photophysical characterization was executed by means of photoluminescence, fluorescence lifetime, quantum efficiency, and radioluminescence under X-ray excitation. POPOP emission was confirmed by absorbing the emissions from benzoic acid and PPO. Radioluminescence results confirmed POPOP emission. Fluorescence lifetime analysis yielded a 1.29 ± 0.01 ns main fast decay (64.2%) combined with a 4.00 ± 0.04 ns slower decay (35.8%). The combined luminescence results suggested that most POPOP in the paper scintillator was solvated. At 301 nm, the average quantum efficiency from both faces of the paper scintillator was about 4%, and at 370 nm, it was about 11%. The paper scintillator detected H β-particles by dipping the paper scintillator into tritiated water without a liquid scintillator. The counting efficiency depended on water content in the paper scintillator, and it increased to above 10% for tritium activity less than 200 dpm since it was preferentially adsorbed by vapor pressure isotopic effect and isotopic exchanged tritium on the surface of the scintillator-silica FP in the paper scintillator. (Tokushima University Institutional Repository) ● Metadata: 119472 (Link to Publication Site) ● Publication site (DOI): 10.1021/acsomega.4c01901 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39035969 ● Search Scopus @ Elsevier (PMID): 39035969 ● Search Scopus @ Elsevier (DOI): 10.1021/acsomega.4c01901 (Tokushima University Institutional Repository: 119472, DOI: 10.1021/acsomega.4c01901, PubMed: 39035969)
3.	Welti E. Sophia, Hirokazu Miyoshi and Hiroshi Yasuda : Radiochromic reactions in repetitive X-ray irradiations of a novel gel complex composed of polyvinyl alcohol, iodide, and silica nanoparticles (PAISiN), Radiation Measurements, Vol.175, 107173-107178, 2024. (Tokushima University Institutional Repository) ● Metadata: 119381 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.radmeas.2024.107173 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.radmeas.2024.107173 (Tokushima University Institutional Repository: 119381, DOI: 10.1016/j.radmeas.2024.107173)
4.	Hirokazu Miyoshi and Mami Nakamura : Preparation of paper scintillators and their effective use in radiation testing alpha- and beta- particles in radioactive liquid, solid, and gas contaminants, Applied Radiation and Isotopes, Vol.206, 111240, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.apradiso.2024.111240 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.apradiso.2024.111240 (DOI: 10.1016/j.apradiso.2024.111240)
5.	Hirokazu Miyoshi and Koichi Okuno : Selective detection of fast and thermal neutrons in mixed-radiation fields using tungstensilica and goldiodinesilica nanoparticles and their boron-loaded aqueous dispersions, Applied Radiation and Isotopes, Vol.202, 111074, 2023. (Keyword) Neutron / Nanoparticles (Link to Publication Site) ● Publication site (DOI): 10.1016/j.apradiso.2023.111074 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.apradiso.2023.111074 (DOI: 10.1016/j.apradiso.2023.111074)
6.	Tamaki Ohtani, Hitoshi Ikushima, Yoshimi Bando, Michiko Yamashita, Kenmei Kuwahara, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi : Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT, The Journal of Medical Investigation : JMI, Vol.70, No.3,4, 361-368, 2023. (Summary) This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023. (Keyword) Humans / Mice / Animals / Carcinoma, Non-Small-Cell Lung / Fluorodeoxyglucose F18 / Positron Emission Tomography Computed Tomography / Lung Neoplasms / Radiopharmaceuticals / Positron-Emission Tomography (Tokushima University Institutional Repository) ● Metadata: 118771 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.361 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940520 ● Search Scopus @ Elsevier (PMID): 37940520 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.361 (Tokushima University Institutional Repository: 118771, DOI: 10.2152/jmi.70.361, PubMed: 37940520)
7.	Hirokazu Miyoshi, Fumio Kida, Kenji Yamada, Mami Nakamura and Hitoshi Hase : Dose responses of scattered- and direct-X-ray-irradiated CR-39 and methylviologen-encapsulated silica nanocapsule-doped CR-39 and their mechanisms, Results in Optics, Vol.12, 100487, 2023. (Tokushima University Institutional Repository) ● Metadata: 118397 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.rio.2023.100487 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.rio.2023.100487 (Tokushima University Institutional Repository: 118397, DOI: 10.1016/j.rio.2023.100487)
8.	Hiroshi Yasuda and Hirokazu Miyoshi : Thermally Controllable Decolorization of Reusable Radiochromic Complex of Polyvinyl Alcohol, Iodine and Silica Nanoparticles (PAISiN) Irradiated with γ-rays, Applied Sciences, Vol.12, No.6, 2959-9, 2022. (Tokushima University Institutional Repository) ● Metadata: 117412 (Link to Publication Site) ● Publication site (DOI): 10.3390/app12062959 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3390/app12062959 (Tokushima University Institutional Repository: 117412, DOI: 10.3390/app12062959)
9.	Tamaki Otani, Hideki Otsuka, Kou Matsushita, Yoichi Otomi, Yamato Kunikane, Shota Azane, Masafumi Amano, Masafumi Harada and Hirokazu Miyoshi : Effect of different examination conditions on image quality and quantitative value of amyloid positron emission tomography using F-flutemetamol., Annals of Nuclear Medicine, Vol.35, No.9, 1004-1014, 2021. (Summary) The recommended start time for F-flutemetamol amyloid positron emission tomography (PET) examination is 60-120 min after F-flutemetamol injection, while an acquisition time of 10-30 min is generally recommended. We aimed to elucidate the effects of different examination conditions on image quality, diagnostic ability, and quantitative value of amyloid PET using F-flutemetamol. We acquired data on a Discovery PET/computed tomography 710 scanner using Hoffman brain and pillar phantoms with 20 MBq of F for 30 min. The images were reconstructed into 10-, 20-, and 30-min periods. The ordered subset-expectation maximization algorithm was used for image reconstruction, which uses a 2- or 4-mm Gaussian filter and a combination of iteration and subset numbers. The percentage contrast and coefficient of variation (CV; as the image noise) were used as physical evaluation indices for reconstructed images, and images with superior contrast and low image noise were selected for clinical evaluation. The imaging data of 15 symptomatic patients (n = 7 and n = 8 for positive and negative diagnoses of Alzheimer's disease, respectively) were reconstructed under the phantom study conditions. Radiographers visually evaluated and ranked the clinical images based on the overall contrast and image noise, and nuclear medicine specialists diagnosed Alzheimer's disease. We compared the standardized uptake value ratio (SUVR) obtained with different acquisition conditions. The basic study using the phantom revealed high convergence of contrast and image noise in five patterns of acquisition time and filter strengths. Regarding visual evaluation, the use of a 2-mm Gaussian filter caused difficulties in diagnosis because the brain parenchymal accumulation was mottled with high image noise. Differences in image quality and diagnostic ability due to different examination times were not significant. Differences in the SUVR were not significant in patients with a negative Alzheimer's disease diagnosis; in patients with a positive diagnosis, the SUVR showed significant fluctuation depending on the acquisition conditions. The differences in image quality and diagnostic performance due to the differences in 10-min acquisition time were not significant; however, of note, SUVR showed significant fluctuation depending on the acquisition conditions in patients diagnosed with Alzheimer's disease. (Link to Publication Site) ● Publication site (DOI): 10.1007/s12149-021-01634-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34046870 ● Search Scopus @ Elsevier (PMID): 34046870 ● Search Scopus @ Elsevier (DOI): 10.1007/s12149-021-01634-3 (DOI: 10.1007/s12149-021-01634-3, PubMed: 34046870)
10.	Masashi Yano, Midori Yoshida, 竹口雅代, Yoko Yamashita and Hirokazu Miyoshi : Report on the Abolition Experience of Several Unsealed RI Facilities in Tokushima University, Japanese Journal of Radiation Safety Management, Vol.19, No.1, 15-22, 2020. (Tokushima University Institutional Repository) ● Metadata: 118670 (Link to Publication Site) ● Publication site (DOI): 10.11269/jjrsm.19.15 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390285300164207744 ● Search Scopus @ Elsevier (DOI): 10.11269/jjrsm.19.15 (Tokushima University Institutional Repository: 118670, DOI: 10.11269/jjrsm.19.15, CiNii: 1390285300164207744)
11.	Hirokazu Miyoshi, Fumio Kida, Yoshiyasu Kawase, Kenji Yamada, Motoharu Sasaki, Hidenori Shoji and Hitoshi Hase : Emission image of X-ray-irradiated CR-39 stick doped with methylviologen-encapsulated silica nanocapsules using LED light, Progress in Nuclear Science and Technology, Vol.6, 91-94, 2019. (Tokushima University Institutional Repository) ● Metadata: 118669 (Link to Publication Site) ● Publication site (DOI): 10.15669/pnst.6.91 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.15669/pnst.6.91 (Tokushima University Institutional Repository: 118669, DOI: 10.15669/pnst.6.91)
12.	Tamaki Otani, Kazuya Kondo, Hiromitsu Takizawa, Koichiro Kajiura, Haruhiko Fujino, Hideki Otsuka and Hirokazu Miyoshi : Noninvasive monitoring of cisplatin and erlotinib efficacy against lung cancer in orthotopic SCID mouse models by small animal FDGPET/CT and CT., Oncology Reports, Vol.41, No.1, 447-454, 2019. (Summary) We established patient-like models of lung cancer metastasis by orthotopically implanting human non-small cell lung cancer cell lines into SCID mice. We evaluated the utilities of small-animal computed tomography (CT) and positron-emission tomography-computed tomography (PET/CT) in these models to non-invasively and repeatedly monitor the anticancer effects of cisplatin and erlotinib. We orthotopically implanted three non-small cell lung cancer cell lines, A549, FT821 and PC-9, into SCID mice. These mice were then divided into three groups: Control, cis-diamminedichloroplatinum (II) (CDDP) (7-mg/kg CDDP, single administration intraperitoneally), and erlotinib (25 mg/kg erlotinib/day, oral administration 5 days/week). After treatment initiation, we repeatedly performed PET/CT and CT measurements and assessed anticancer effects based on tumor volumes and FDG uptake. A549 tumors were not affected by CDDP or erlotinib. FT821 tumors were highly responsive to CDDP. PC-9 tumors, which have an epidermal growth factor receptor mutation, were highly responsive to erlotinib. Histological results and metastatic rates correlated with the anticancer effects shown by CT. In our orthotopic SCID mouse lung cancer models, 18FDG-PET/CT and CT imaging non-invasively and repeatedly monitored the efficacies of cisplatin and erlotinib against not only implanted tumors, but also mediastinal lymph node metastases. (Keyword) Animals / Carcinoma, Non-Small-Cell Lung / Cell Line, Tumor / Cisplatin / Erlotinib Hydrochloride / Fluorodeoxyglucose F18 / Humans / Lung Neoplasms / Lymph Nodes / Lymphatic Metastasis / male / Mice / Mice, SCID / Positron Emission Tomography Computed Tomography / Positron-Emission Tomography / Tomography, X-Ray Computed / Tumor Burden (Link to Publication Site) ● Publication site (DOI): 10.3892/or.2018.6818 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30365151 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056802482 (DOI: 10.3892/or.2018.6818, PubMed: 30365151, Elsevier: Scopus)
13.	Tamiko Nagao, Haruyuki Nakayama-Imaohji, Miad Etahi, Ayano Tada, Emika Toyonaga, Hisashi Yamasaki, Katsuichiro Okazaki, Hirokazu Miyoshi, Koichiro Tsuchiya and Tomomi Kuwahara : L-histidine augments the oxidative damage against Gram-negative bacteria by hydrogen peroxide, International Journal of Molecular Medicine, Vol.41, No.5, 2847-2854, 2018. (Summary) Excessive damage to DNA and lipid membranes by reactive oxygen species reduces the viability of bacteria. In the present study, the proliferation of recA-deficient Escherichia coli strains was revealed to be inhibited by 1% L-histidine under aerobic conditions. This inhibition of proliferation was not observed under anaerobic conditions, indicating that L-histidine enhances oxidative DNA damage to E. coli cells. Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that the expression of recA in E. coli MG1655 increased ~7-fold following treatment with 10 mM hydrogen peroxide (H2O2) plus 1% L-histidine, compared with that following exposure to H2O2 alone. L-histidine increased the genomic fragmentation of E. coli MG1655 following exposure to H2O2. In addition, L-histidine increased the generation of intracellular hydroxyl radicals in the presence of H2O2 in E. coli cells. Next, our group investigated the disinfection properties of the H2O2 and L-histidine combination. The combination of 100 mM H2O2 and 1.0% L-histidine significantly reduced the number of viable cells of extended-spectrum-β-lactamase-producing E. coli and multidrug-resistant Pseudomonas aeruginosa, and this treatment was more effective than 100 mM H2O2 alone, but this effect was not observed in methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus faecium. The combination of L-histidine and H2O2 may be a useful strategy to selectively increase the microbicidal activity of oxidative agents against Gram-negative bacteria. (Keyword) Anti-Bacterial Agents / DNA Damage / Disinfection / Escherichia coli / Gram-Negative Bacteria / Gram-Negative Bacterial Infections / Histidine / Humans / Hydrogen Peroxide / Oxidants / Oxidative Stress / Reactive Oxygen Species (Link to Publication Site) ● Publication site (DOI): 10.3892/ijmm.2018.3473 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29436593 ● Search Scopus @ Elsevier (PMID): 29436593 ● Search Scopus @ Elsevier (DOI): 10.3892/ijmm.2018.3473 (DOI: 10.3892/ijmm.2018.3473, PubMed: 29436593)
14.	Hirokazu Miyoshi, Mitsunori Hiroura, Kazunori Tsujimoto, Namiko Irikura, Tamaki Otani and Yasuo Shinohara : Preparation of new scintillation imaging material composed of scintillator-silica fine powders and its imaging of tritium, Radiation Protection Dosimetry, Vol.174, No.4, 478-484, 2017. (Summary) A new scintillation imaging material [scintillator-silica fine powder (FP)] was prepared using silica FPs and scintillator-encapsulating silica nanoparticles (NPs) (scintillator-silica NPs). The wt% values of scintillator-silica NPs on the scintillator-silica FPs were 38, 43, 36 and 44%. Scintillation images of 3H, 63Ni, 35S, 33P, 204Tl, 89Sr and 32P dropped on the scintillator-silica FPs were obtained at about 37 kBq per 0.1-10 µl with a charge-coupled device (CCD) imager for a 5 min exposure. In particular, high-intensity CCD images of 35S were selectively obtained using the 2.25, 4.77 and 10 µm silica FPs with scintillator-silica NPs owing to the residual S of dimethyl sulfoxide in the preparation. Scintillation images of 3H at 1670 ± 9 Bq/0.5 µl and 347 ± 6 Bq/0.5 µl dropped in a 2 mm hole on the scintillator-silica FPs (6.78 and 10 µm) were also obtained using the CCD imager for a 2 h exposure. (Link to Publication Site) ● Publication site (DOI): 10.1093/rpd/ncw251 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27664433 ● Search Scopus @ Elsevier (PMID): 27664433 ● Search Scopus @ Elsevier (DOI): 10.1093/rpd/ncw251 (DOI: 10.1093/rpd/ncw251, PubMed: 27664433)
15.	Hirokazu Miyoshi, Akira Yumoto, Masayuki Shono, Tomoyuki Ueki and Yoshinori Itsuki : Visualization of PVDF nanofibers coated on filter paper using fluorescein silica nanoparticles, Journal of Applied Polymer Science, Vol.134, No.30, 45125, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1002/app.45125 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/app.45125 (DOI: 10.1002/app.45125)
16.	Hirokazu Miyoshi, Hitoshi Gotoh, Mitsunori Hiroura, Yusuke Yamanaka, Namiko Irikura, Tamaki Otani and Yuko Yamamoto : Enhancement of counting efciency for tritium using light-excited scintillator silica pellets, Journal of Radioanalytical and Nuclear Chemistry, Vol.311, No.3, 1991-1999, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10967-017-5185-2 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s10967-017-5185-2 (DOI: 10.1007/s10967-017-5185-2)
17.	Namiko Irikura, Hirokazu Miyoshi and Yasuo Shinohara : Scintillation imaging of tritium radioactivity distribution during tritiated thymidine uptake by PC12 cells using a melt-on scintillator, Applied Radiation and Isotopes, Vol.120, 11-16, 2016. (Summary) A scintillation image of tritium fixed in a melt-on scintillator was obtained using a charged-coupled device (CCD) imager, and a linear relationship was observed between the intensity of the scintillation image and the radioactivity of tritium. In a [(3)H]thymidine uptake experiment, a linear correlation between the intensity of the CCD image and the dilution ratio of cells was confirmed. Scintillation imaging has the potential for use in direct observation of tritium radioactivity distribution. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.apradiso.2016.11.003 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27894045 ● Summary page in Scopus @ Elsevier: 2-s2.0-84998886255 (DOI: 10.1016/j.apradiso.2016.11.003, PubMed: 27894045, Elsevier: Scopus)
18.	Hirokazu Miyoshi, Yuji Mashiko, Sunao Maeda, Kenji Yamada and Jiro Matsumura : Reversible radiochromic plate based on polyvinyl alcohol-iodide complex containing silica nanoparticles, Journal of Radioanalytical and Nuclear Chemistry, Vol.308, No.2, 469-475, 2016. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10967-015-4465-y (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84944707168 (DOI: 10.1007/s10967-015-4465-y, Elsevier: Scopus)
19.	Hirokazu Miyoshi, Fumio Kida, Kenji Yamada, Koichiro Tsuchiya and Hase Hitoshi : Optical property of CR-39 synthesized by doping with methylviologen-encapsulated SiO2 nanocapsules as a solid-state X-ray plate detector, Optical Materials, Vol.55, 109-114, 2016. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.optmat.2016.02.042 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.optmat.2016.02.042 (DOI: 10.1016/j.optmat.2016.02.042)
20.	Hirokazu Miyoshi, Fumio Kida, Hitoshi Hase and Koichiro Tsuchiya : Silica-nanocapsule-doped CR-39 for fluorescence detection of Xrays, Physics Procedia, Vol.80, 90-93, 2015. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.phpro.2015.11.100 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.phpro.2015.11.100 (DOI: 10.1016/j.phpro.2015.11.100)
21.	Hirokazu Miyoshi, 森脇崇, 川口佳彦 and Shintaro Nakayama : Simultaneous Measurement of Dispersal and Adhesion Rates of Tritium using Filter Paper and a Model Room, Japanese Journal of Radiation Safety Management, Vol.14, No.1, 27-31, 2015. (Summary) Tritium dispersal rate in the air and adhesion rate on the wall from a 3H-ATP aqueous solution were simultaneously measured using a model room having six pieces of filter paper attached on the wall. A distribution of tritium on each wall was obtained from the radioactivity of each filter paper divided into 9 pieces. During an exposure time of 2 h to 24 h both dispersal and adhesion rates indicated a similar behavior. With the passage time from the purchase until 13 months both dispersal and adhesion rates linearly increased and it was found that about 0.15% per one month increased as the total rates of dispersal and adhesion. (Keyword) tritium / dispersal rate / adhesion rate / filter paper (Link to Publication Site) ● Publication site (DOI): 10.11269/jjrsm.14.27 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205226450816 ● Search Scopus @ Elsevier (DOI): 10.11269/jjrsm.14.27 (DOI: 10.11269/jjrsm.14.27, CiNii: 1390001205226450816)
22.	Tamaki Otani, Hideki Otsuka, Kazuya Kondo, Hiromitsu Takizawa, Motoi Nagata, Mina Kishida and Hirokazu Miyoshi : Utility of respiratory-gated small-animal PET/CT in the chronologic evaluation of an orthotopic lung cancer transplantation mouse model., Radiological Physics and Technology, Vol.8, No.2, 266-277, 2015. (Summary) Our aim in this study was to clarify the effects of respiratory-gated PET in the evaluation of lung cancer according to the (18)F-FDG uptake in an orthotopic transplantation mouse model. We created such a model, and we performed PET/CT. The mice were divided into two groups according to tumor volume: a small-tumor group (<20 mm(3)) and a large-tumor group (>20 mm(3)). We reconstructed the following conditions based on list-mode data: non-gated (3D) images and gated (4D) images, divided based on the respiratory cycle (expiration phase, stable phase, and inspiration phase). We calculated the maximum standardized uptake values (SUVmax) in each phase. We used the % difference [= (4D SUVmax - 3D SUVmax)/3D PET SUVmax × 100 (%)] to evaluate the differences in the 4D SUVmax and 3D SUVmax. The 4D SUVmax values were significantly higher than the 3D SUVmax, regardless of the tumor size. The % difference for the small tumors was greater than that for the large tumors, and it was highest in the stable phase. We conclude that the SUVmax in the stable phase under respiratory-gated PET are the most reliable. The SUVmax observed under non-gated PET are considered to be more frequently underestimated in cases involving small tumors than in those involving large tumors. In the chronologic study evaluating the time course of tumor development, the size of the tumor is small in early stage, and respiratory-gated PET is effective in reducing the underestimation of such tumors caused by respiratory motion. (Tokushima University Institutional Repository) ● Metadata: 109701 (Link to Publication Site) ● Publication site (DOI): 10.1007/s12194-015-0316-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25921487 ● Summary page in Scopus @ Elsevier: 2-s2.0-84937518832 (Tokushima University Institutional Repository: 109701, DOI: 10.1007/s12194-015-0316-3, PubMed: 25921487, Elsevier: Scopus)
23.	Namiko Irikura and Hirokazu Miyoshi : メルトオンシンチレータを用いたトリチウム放射能の画像化, Japanese Journal of Radiation Safety Management, Vol.13, No.2, 154-158, 2014. (Link to Publication Site) ● Publication site (DOI): 10.11269/jjrsm.13.154 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205225001088 ● Search Scopus @ Elsevier (DOI): 10.11269/jjrsm.13.154 (DOI: 10.11269/jjrsm.13.154, CiNii: 1390001205225001088)
24.	Hirokazu Miyoshi, Tamaki Otani and Namiko Irikura : In situ 18F-gamma-ray induced Ag nanoparticle formation in the presence of SiO2 nanoparticles under air, Journal of Radioanalytical and Nuclear Chemistry, Vol.302, No.3, 1177-1183, 2014. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10967-014-3359-8 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84919413696 (DOI: 10.1007/s10967-014-3359-8, Elsevier: Scopus)
25.	Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Kikuo Shimizu, Kazuyoshi Masumoto, Masahiro Hirota, Shogo Higaki, Hirokazu Miyoshi, Takuya Saze, Minoru Sakama and Makoto Yanaga : Decontamination of radioactivity from contaminated vegetables derived from the Fukushima nuclear accident, Radiation Measurements, Vol.55, 26-29, 2013. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.radmeas.2013.01.010 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.radmeas.2013.01.010 (DOI: 10.1016/j.radmeas.2013.01.010)
26.	Hong Yang, Fenglong Zhao, Ying Li, Chunhui Wu, Hirokazu Miyoshi and Yiyao Liu : VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro, International Journal of Nanomedicine, Vol.8, 1897-1906, 2013. (Summary) Multifunctional nanomaterials with unique magnetic and luminescent properties have broad potential in biological applications. Because of the overexpression of vascular cell adhesion molecule-1 (VCAM-1) receptors in inflammatory endothelial cells as compared with normal endothelial cells, an anti-VCAM-1 monoclonal antibody can be used as a targeting ligand. Herein we describe the development of multifunctional core-shell Fe(3)O(4)@SiO2 nanoparticles with the ability to target inflammatory endothelial cells via VCAM-1, magnetism, and fluorescence imaging, with efficient magnetic resonance imaging contrast characteristics. Superparamagnetic iron oxide and fluorescein isothiocyanate (FITC) were loaded successfully inside the nanoparticle core and the silica shell, respectively, creating VCAM-1-targeted Fe(3)O(4)@SiO2(FITC) nanoparticles that were characterized by scanning electron microscopy, transmission electron microscopy, fluorescence spectrometry, zeta potential assay, and fluorescence microscopy. The VCAM-1-targeted Fe(3)O(4)@SiO2(FITC) nanoparticles typically had a diameter of 355 ± 37 nm, showed superparamagnetic behavior at room temperature, and cumulative and targeted adhesion to an inflammatory subline of human umbilical vein endothelial cells (HUVEC-CS) activated by lipopolysaccharide. Further, our data show that adhesion of VCAM-1-targeted Fe(3)O(4)@SiO2(FITC) nanoparticles to inflammatory HUVEC-CS depended on both shear stress and duration of exposure to stress. Analysis of internalization into HUVEC-CS showed that the efficiency of delivery of VCAM-1-targeted Fe(3)O(4)@SiO2(FITC) nanoparticles was also significantly greater than that of nontargeted Fe(3)O(4)@SiO2(FITC)-NH2 nanoparticles. Magnetic resonance images showed that the superparamagnetic iron oxide cores of the VCAM-1-targeted Fe(3)O(4)@SiO2(FITC) nanoparticles could also act as a contrast agent for magnetic resonance imaging. Taken together, the cumulative adhesion and uptake potential of these VCAM-1-targeted Fe(3)O(4)@SiO2(FITC) nanoparticles targeted to inflammatory endothelial cells could be used in the transfer of therapeutic drugs/genes into these cells or for diagnosis of vascular disease at the molecular and cellular levels in the future. (Keyword) Analysis of Variance / Antibodies, Monoclonal / Drug Carriers / Human Umbilical Vein Endothelial Cells / Humans / Inflammation / Lipopolysaccharides / Magnetic Resonance Imaging / Magnetite Nanoparticles / Silicon Dioxide / Vascular Cell Adhesion Molecule-1 (Link to Publication Site) ● Publication site (DOI): 10.2147/IJN.S44997 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23696701 ● Summary page in Scopus @ Elsevier: 2-s2.0-84877878942 (DOI: 10.2147/IJN.S44997, PubMed: 23696701, Elsevier: Scopus)
27.	Hiroaki Hayashi, Hiroki Hanamitsu, Sadamitsu Nishihara, Junji Ueno and Hirokazu Miyoshi : Proposal of an experiment of the cloud chamber using the diagnostic X-ray apparatus and an analysis assisted by the simulation code, Japanese Journal of Radiological Technology, Vol.69, No.4, 386-392, 2013. (Summary) A cloud chamber is a radiation detector that can visualize the tracks of charged particles. In this study, we developed a middle-type cloud chamber for use in practical training using a diagnostic X-ray apparatus. Because our cloud chamber has a heater to vaporize ethanol and features antifogging glass, it is possible to observe the vapor trails for a long time without the need for fine adjustments. X-rays with a tube voltage of 40 kV or of 120 kV (with a 21-mm aluminum filter) were irradiated at the chamber and the various phenomena were observed. We explain these phenomena in terms of the range of electrons and/or interactions between X-rays and matter and conclude that our analysis is consistent with analysis using the Monte Carlo simulation code EGS5. (Keyword) cloud chamber / radioisotopes / X-ray / practical training (Tokushima University Institutional Repository) ● Metadata: 113652 (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.2013_JSRT_69.4.386 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23609860 ● CiNii @ National Institute of Informatics (CRID): 1390282681337767040 ● Search Scopus @ Elsevier (PMID): 23609860 ● Search Scopus @ Elsevier (DOI): 10.6009/jjrt.2013_JSRT_69.4.386 (Tokushima University Institutional Repository: 113652, DOI: 10.6009/jjrt.2013_JSRT_69.4.386, PubMed: 23609860, CiNii: 1390282681337767040)
28.	Hirokazu Miyoshi and Toshiji Ikeda : Preparation of Paper Scintillator for Detecting 3H Contaminant, Radiation Protection Dosimetry, Vol.156, No.3, 277-282, 2013. (Link to Publication Site) ● Publication site (DOI): 10.1093/rpd/nct079 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1093/rpd/nct079 (DOI: 10.1093/rpd/nct079)
29.	Hirokazu Miyoshi : Removal of radioactive iodine and cesium species from rainwater by a pot-type water purifier and chemical and physical analysis of radioactive components in rainwater, Radiation Safety Management, Vol.12, No.1, 1-8, 2013. (Summary) A pot-type water purifier captured 98% of the nonradioactive iodine and iodide when an ion-exchange resin and activated carbon were used. Approximately 93.8% of 131I, 74 to 84.5% of 134Cs, and 75 to 81.1% of 137Cs in rainwater were captured after six repeated purifications using the purifier. The remaining 6.2% of 131I was not removed by isotope exchange with nonradioactive I- or by reduction to I- using Na2S2O4. Approximately 19% of 131I, 40% of 134Cs, and 33% of 137Cs were adsorbed on the silica gel. Analysis of the removal rates of 73% for the mixed ion exchange resin, 59% for the silver ions, and 18% for the silver nanoparticle-bound clay indicated that the content of 131I adsorbed particles components was 23%. The concentration ratio of radioactive components in rainwater decreased from 5.9 to 1.4 upon ultrafiltration with a YM-1 membrane filter, indicating that a soft aggregation of the aerosol occurred. The IP and γ-ray spectrum analysis of the filter produced a cottonlike image of 131I. Analysis of the TEM image and its electron diffraction pattern indicated the aggregation of a small fraction of the SiO2 aerosol. The coagulation of radioactive components in rainwater using I-adsorbed SiO2 nanoparticles may be due to the exchange of the 131I isotope with I in I-SiO2 and the adsorption of 134Cs+ and 137Cs+ on the surface of SiO2 or the precipitation of the 131I-adsorbed aerosol and 134Cs- and 137Cs-adsorbed aerosols. (Keyword) removal / radioactive iodine / radioactive cesium / rainwater / analysis (Link to Publication Site) ● Publication site (DOI): 10.12950/rsm.12.1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205225487104 ● Search Scopus @ Elsevier (DOI): 10.12950/rsm.12.1 (DOI: 10.12950/rsm.12.1, CiNii: 1390001205225487104)
30.	Hirokazu Miyoshi : Separation of radioactive cesium and iodine from contaminated soil by adsorption and decantation, Radiation Safety Management, Vol.12, No.1, 9-15, 2013. (Summary) Approximately 19% of 131I was released in a solution mixing contaminated soil with distilled water and 10 wt% CaCl2 solution, and the remaining 131I tightly bound to the soil. Approximately 12 to 15% of the radioactive cesium was found in the supernatant after mixing with saturated KCl aqueous solution, and the repeated treatment for 1 day indicated the additional release of 11 to 15% in the supernatant. Approximately 15 to 20% of radioactive cesium was found in the supernatant by mixing with saturated KCl solution and KCl powder, followed by heating. The repeated treatment with 40% KI solution led to a maximum release rate of 66% of radioactive cesium from the soil. (Keyword) separation / radioactive cesium / radioactive iodine / soil / adsorption (Link to Publication Site) ● Publication site (DOI): 10.12950/rsm.12.9 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680202199424 ● Search Scopus @ Elsevier (DOI): 10.12950/rsm.12.9 (DOI: 10.12950/rsm.12.9, CiNii: 1390282680202199424)
31.	Hirokazu Miyoshi, Toshiji Ikeda and Takao Kojima : γ-Ray Induced Catalytic Properties of the Silica Nanoparticles Dispersed in the Aerated Aqueous Solution, Journal of Radioanalytical and Nuclear Chemistry, Vol.295, No.3, 1903-1912, 2013. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10967-012-2161-8 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s10967-012-2161-8 (DOI: 10.1007/s10967-012-2161-8)
32.	Hirokazu Miyoshi : Decontamination of radioactive-iodine- and cesium-contaminated spinach using sodium dithionite, Radiation Safety Management, Vol.11, No.1, 1-3, 2012. (Summary) Washing of the spinach with water by the Nishizawa method resulted in the removal of about 13 ± 2% of the 131I and 45 ± 20% of the 134Cs and 137Cs. Removal rates of 131I of approximately 76 ± 3% after further washing with 1.2 wt% Na2S2O4 for 2 days and 47 ± 2% washing with 10 wt% Na2S2O4 for 2 days were obtained. These values agreed with the dissolution rates of 131I in the liquid used for washing within 2 to 3% error. The removal rates of 134Cs and 137Cs after washing with 1.2 wt% Na2S2O4 for 2 days were 69 ± 47% and 100 ± 52%, respectively, which were in poor agreement with the corresponding dissolution rates. The removal rate of 131I after brief washing with 10 wt% Na2S2O4 was negligible and the dissolution rate was 5 ± 2%. The removal rates of 134Cs and 137Cs for 10 wt% Na2S2O4 increased from 26 ± 11% to 42 ± 11% and from 30±20% to 42 ± 20% after washing with Na2S2O4 for 2 days. The high removal rates in 1.2 wt% Na2S2O4 may be due to the effective reduction of the I2 on the surface of the leaves by Na2S2O4 (1.2 wt%) during the 2 day immersion, which occurred without the bleaching of the leaves and stalks, which occurred in the case of 10 wt% Na2S2O4. (Link to Publication Site) ● Publication site (DOI): 10.12950/rsm.11.1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680203683072 ● Search Scopus @ Elsevier (DOI): 10.12950/rsm.11.1 (DOI: 10.12950/rsm.11.1, CiNii: 1390282680203683072)
33.	Hiroaki Hayashi, Sadamitsu Nishihara, Satoru Takashi, Hiroki Hanamitsu, Michiko Mori, Hirokazu Miyoshi and Yoji Onuma : Estimation of activities caused by black spots for digital radiography system, --- Analysis of black spots by the low concentrate radioisotopes adhered directly to the surface of the phosphor plate ---, Japanese Journal of Radiological Technology, Vol.68, No.11, 1467-1473, 2012. (Summary) Because of an accident of the nuclear power plants in the Fukushima, many radioisotopes (RI) have been diffused to the environment. As a result, black spots were appearing on the medical images which were taken by the phosphor plate. The aim of this study is to evaluate the activity (Bq) of radioactive contaminated IP based on the experiment using RI. The radioactive material (134Cs and/or 137Cs) in the form of liquid was dropped on filter paper (25 mm2), and radioactive sources having 40 240 Bq activities were made. These sources were closely attached to the IP with irradiation times of 2 22 h. Then, we obtained the relationship between pixel values and products of activities and irradiation times. Using these relationships, we evaluated the activity in the contaminated IP. The evaluated value of approximately 7 Bq was in good agreement with a value which was inhered in a chemical wiper used for the decontamination of the IP. Based on the results, we summarized that almost all black spots were created by the RI adhered directly to the IP. (Keyword) imaging plate / black spots / radioisotopes (Tokushima University Institutional Repository) ● Metadata: 113653 (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.2012_JSRT_68.11.1467 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282681340418944 ● Summary page in Scopus @ Elsevier: 2-s2.0-84884296102 (Tokushima University Institutional Repository: 113653, DOI: 10.6009/jjrt.2012_JSRT_68.11.1467, CiNii: 1390282681340418944, Elsevier: Scopus)
34.	Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Hirokazu Miyoshi and Makoto Yanaga : Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident, Radiation Safety Management, Vol.11, No.1, 23-26, 2012. (Summary) We examined a simple and effective removal method for contaminated farm products to ensure the relief of farmers and the security of consumers. Removal of radionuclides from spinach by chemical methods was investigated. The result of chemical removal showed that antioxidant agents removed radionuclides from spinach by 70-80% for 131I and more than 80% for radiocesium. In particular, ascorbic acid is promising as a safe and versatile option. (Link to Publication Site) ● Publication site (DOI): 10.12950/rsm.11.23 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205226994048 ● Search Scopus @ Elsevier (DOI): 10.12950/rsm.11.23 (DOI: 10.12950/rsm.11.23, CiNii: 1390001205226994048)
35.	Hirokazu Miyoshi and 梅原孝雄 : Improvement of an X-ray Diffraction Equipment for the X-ray Safety Education, Radioisotopes, Vol.61, No.5, 243-253, 2012. (Link to Publication Site) ● Publication site (DOI): 10.3769/radioisotopes.61.243 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3769/radioisotopes.61.243 (DOI: 10.3769/radioisotopes.61.243)
36.	Hirokazu Miyoshi, Kensho Sakamoto, Masashi Kurashina and Eiji Kanezaki : Photoinduced Electron Accumulation of Titanium Dioxide Nanoparticle Modified Electrodes, International Journal of Modern Physics: Conference Series, Vol.6, No.1, 61-66, 2012. (Link to Publication Site) ● Publication site (DOI): 10.1142/S2010194512002942 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1142/S2010194512002942 (DOI: 10.1142/S2010194512002942)
37.	Nobumitsu Sakai, Masato Takakura, Harutoshi Imamura, Miki Sugimoto, Yasuto Matsui, Hirokazu Miyoshi, Aki Nakayama and Minoru Yoneda : Whole-Body Distribution of ¹⁴C-labeled Silica Nanoparticles and Submicron Particles after Intravenous Injection into Mice, Journal of Nanoparticle Research, Vol.14, 849-859, 2012. (Link to Publication Site) ● Publication site (DOI): 10.1007/s11051-012-0849-x (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s11051-012-0849-x (DOI: 10.1007/s11051-012-0849-x)
38.	今村治世, 髙倉誠人, 坂井伸光, 中山亜紀, 佐々木克典, 真見一樹, Hirokazu Miyoshi, 杉本実紀, 杉本実紀 and 米田稔 : ICRマウスにおける44nm14C標識シリカナノ粒子を用いた体内動態評価モデルの構築, 土木学会論文集G(環境), Vol.67, No.7, 223-232, 2011.
39.	Eriko Obana, Takuya Hada, Takenori Yamamoto, Rei Kakuhata, Takuya Saze, Hirokazu Miyoshi, Tomoshige Hori and Yasuo Shinohara : Properties of signal intensities observed with individual probes of GeneChip Rat Gene 1.0 ST Array, an affymetric microarray system., Biotechnology Letters, Vol.34, No.2, 213-219, 2011. (Summary) For proper evaluation of the results of microarray experiments, it is important to understand how the signal intensities of individual probes are determined. Our previous studies revealed that signal intensities of individual probes in the Agilent array system (code G4131F) are largely dependent upon the location of the probes in the mRNA. In the present study, we examined the properties of signal intensities of individual probes in an Affymetrix array system (GeneChip Rat Gene 1.0 ST Array), in which a random primer fused to the T7 promoter sequence is employed. Distinct from the Agilent array system, individual probes used in this Affymetrix array system did not show the probe-location effects, but gave relatively diverse signal intensities. However, the diversities of the signal intensities of these individual probes were not due to experimental error. (Keyword) Animals / Gene Expression Profiling / Oligonucleotide Array Sequence Analysis / Oligonucleotide Probes / Podoviridae / Promoter Regions, Genetic / Rats (Link to Publication Site) ● Publication site (DOI): 10.1007/s10529-011-0776-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22009574 ● Search Scopus @ Elsevier (PMID): 22009574 ● Search Scopus @ Elsevier (DOI): 10.1007/s10529-011-0776-4 (DOI: 10.1007/s10529-011-0776-4, PubMed: 22009574)
40.	Hong Yang, Changchun Lou, Mingming Xu, Chunhui Wu, Hirokazu Miyoshi and Yiyao Liu : Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism, International Journal of Nanomedicine, Vol.6, 2023-2032, 2011. (Summary) Multifunctionalized nanoparticles (NPs) are emerging as ideal tools for gene/drug delivery, bioimaging, labeling, or intracellular tracking in biomedical applications, and have attracted considerable attention owing to their unique advantages. In this study, fluorescent silica NPs were synthesized by a modified Stöber method using conjugates of 3-mercaptopropyltrimethoxysilane (MPS) and maleimide-fluorescein isothiocyanate (maleimide-FITC). Mean diameters of the NPs were controlled between 212-2111 nm by regulating MPS concentration in the reaction mixture. Maleimide-FITC molecules were doped into NPs or conjugated to the surface of NPs through the chemical reaction of maleimide and thiol groups. The data showed that the former NPs are better than the latter by comparing their fluorescence intensity. Furthermore, folate molecules were linked to the FITC-doped silica NPs by using polyethylene glycol (PEG) (NH2-PEG-maleimide) as a spacer, thus forming folate receptor targeting fluorescent NPs, referred to as NPs(FITC)-PEG-Folate. The quantitative analysis of cellular internalization into different cancer cells showed that the delivery efficiency of KB cells (folate receptor-positive cells) is more than six-fold higher than that of A549 cells (folate receptor-negative cells). The delivery efficiency of KB cells decreased significantly after free folate addition to the cell culture medium because the folate receptors were occupied by the free folate. The NPs endocytosis mechanism was also investigated. It was shown that clathrin, an inhibitor of cell phagocytosis, markedly decreased the NPs uptake into KB cells, suggesting that it plays an important role in NPs cellular internalization. These results demonstrated that the novel particles of NPs(FITC)-PEG-Folate are promising for fluorescent imaging or targeting delivery to folate receptor-positive tumors. (Keyword) Carcinoma / Cell Line, Tumor / Cell Proliferation / Endocytosis / Fluorescein-5-isothiocyanate / Folate Receptors, GPI-Anchored / Folic Acid / Humans / KB Cells / Microscopy, Electron, Transmission / Nanoconjugates / Polyethylene Glycols / Silanes / Silicon Dioxide (Link to Publication Site) ● Publication site (DOI): 10.2147/IJN.S24792 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21976977 ● Search Scopus @ Elsevier (PMID): 21976977 ● Search Scopus @ Elsevier (DOI): 10.2147/IJN.S24792 (DOI: 10.2147/IJN.S24792, PubMed: 21976977)
41.	Mengran Shi, Yiyao Liu, Mingming Xu, Hong Yang, Chunhui Wu and Hirokazu Miyoshi : Core/Shell Fe3O4 @ SiO2 Nanoparticles Modified with PAH as a Vector for EGFP Plasmid DNA Delivery into Hela Cells, Macromolecular Bioscience, Vol.11, No.11, 1563-1569, 2011. (Summary) Novel stable core/shell Fe(3)O(4)@SiO(2)/PAH nanoparticles are synthesized using 15 nm Fe(3)O(4) as the template that is modified with PAH. The resulting nanoparticles can absorb plasmid DNA to mediate gene transfer in cultured HeLa cells. An electrophoretic assay suggests that the Fe(3)O(4)@SiO(2)/PAH nanoparticles protect the plasmid DNA from serum and DNase I degradation. A cell viability assay shows that the Fe(3)O(4)@SiO(2)/PAH nanoparticles exhibit a low cytotoxicity toward endothelial cells. Qualitative analysis of transfection in HeLa cells by nanoparticles carrying a plasmid DNA encoding EGFP demonstrates a fairly high expression level, even in the presence of serum. Thus, Fe(3)O(4)@SiO(2)/PAH nanoparticles are biocompatible and suitable for nonviral delivery, and may find applications in cancer therapy. (Keyword) Biocompatible Materials / Cell Survival / DNA / Deoxyribonuclease I / Female / Ferumoxytol / Gene Therapy / Genes, Reporter / Green Fluorescent Proteins / HeLa Cells / Humans / Magnetite Nanoparticles / Plasmids / Polyamines / Silicon Dioxide / Transfection / Uterine Cervical Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1002/mabi.201100150 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22052564 ● Search Scopus @ Elsevier (PMID): 22052564 ● Search Scopus @ Elsevier (DOI): 10.1002/mabi.201100150 (DOI: 10.1002/mabi.201100150, PubMed: 22052564)
42.	Hirokazu Miyoshi, Yuko Kazumori and Shintaro Nakayama : Preparation of ³H-ATP-incorporated silica nanoparticles and its diffusive release, Journal of Non-Crystalline Solids, Vol.356, No.50-51, 2889-2895, 2010. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jnoncrysol.2010.09.017 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jnoncrysol.2010.09.017 (DOI: 10.1016/j.jnoncrysol.2010.09.017)
43.	Hirokazu Miyoshi, Shuhei Katayama, Masashi Kurashina and Eiji Kanezaki : Novel Accumulation of Photo-Induced MV+ Embedded in a TiO2 Shell and Discharge of Electrons to a Pt Electrode, Chemical Communications, Vol.46, No.21, 3797-3799, 2010. (Summary) After UV-irradiation of a TiO(2) shell on Pt anode was cut off, anodic current was observed continuously for some time because long-lived MV(+)* produced from MV(2+) embedded inside the shell, as a result of the electron transfer from the conduction band of the irradiated TiO(2) shell, diffused slowly and discharged to the shell thus realizing electron accumulation inside the TiO(2) shell. (Link to Publication Site) ● Publication site (DOI): 10.1039/c000262c (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20393664 ● Search Scopus @ Elsevier (PMID): 20393664 ● Search Scopus @ Elsevier (DOI): 10.1039/c000262c (DOI: 10.1039/c000262c, PubMed: 20393664)
44.	Hirokazu Miyoshi, Hideki Ohno, Keisuke Sakai, Naho Okamura and Hiroki Kourai : Characterization and photochemical and antibacterial properties of highly stable silver nanoparticles prepared on montmorillonite clay in n-hexanol, Journal of Colloid and Interface Science, Vol.345, No.2, 433-441, 2010. (Summary) Ag nanoparticles (NPs) of approximately 2.5±0.6nm in size with high stability were prepared on montmorillonite clay in n-hexanol ([Ag NP/clay]). The aqueous suspensions of Ag NP/clay obtained were colored pale yellow to gray, and an intense yellow surface plasmon band was observed at approximately 397-422nm at a [Ag(+)] concentration of 0.01-1M. Fluorescence peaks of these Ag NP/clay suspensions, which were due to interband transitions of Ag NPs, were observed at approximately 447nm upon excitation at approximately 341nm. Photoinduced charge separation and electron accumulation in the presence of 2-propanol were observed in the Ag NPs on the clay. The photogenerated holes indicate a reaction with OH(-) because the generation of ()OH radicals decreased in the presence of 2-propanol, as observed using a spin-trapping electron spin resonance (ESR) method. The amount of H(2) produced depended on the amount of Ag NPs on the clay and the concentration of 2-propanol in the suspension. Antibacterial activity of Ag NPs on clay was also observed against Escherichia coli even after 12years. This simple method of preparation in n-hexanol led to the successful formation of highly stable and photoactive Ag NPs on montmorillonite clay. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcis.2010.01.034 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20172529 ● Search Scopus @ Elsevier (PMID): 20172529 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcis.2010.01.034 (DOI: 10.1016/j.jcis.2010.01.034, PubMed: 20172529)
45.	Hong Yang, Zhong-hau Liu, Yi-yao Liu, Chang-chun Lou, Zheng-long Ren and Hirokazu Miyoshi : Vascular gene transfer and drug delivery in vitro using low-frequency ultrasound and microbubbles, Acta Pharmacologica Sinica, Vol.31, No.4, 515-522, 2010. (Summary) To determine the effects of ultrasound exposure in combination with a microbubble contrast agent (SonoVue) on the cellular uptake and delivery of drugs/genes into human umbilical vein endothelial cells (HUVECs) as well as their biological effects on migration. HUVECs in suspension were exposed to pulsed ultrasound with a 10% duty cycle in combination with various concentrations of a microbubble contrast agent (SonoVue) using a digital sonifier at a frequency of 20 kHz and an intensity of 3.77 W/cm(2) on the surface of a horn tip. Cell culture inserts were used to determine the cell migration ability. Exposure to pulsed ultrasound resulted in enhanced green fluorescent protein (EGFP) gene transfection efficiencies ranging from 0.2% to 2%. The transfection efficiency of HUVECs was approximately 3-fold higher in the presence of SonoVue than in its absence at the effective exposure time of 6 s. For drug delivery to HUVECs using ultrasound, the delivery efficiencies of a low-molecular-weight model drug (TO-PRO-1, M(W) 645.38) were significantly higher when compared to drug delivery without ultrasound, with a maximum efficiency of approximately 34%. However, the delivery efficiencies of a high-molecular-weight model drug (Dextran-Rhodamine B, M(W) 70,000) were low, with a maximum delivery efficiency of nearly 0.5%, and gene transfection results were similarly poor. The migration ability of HUVECs exposed to ultrasound was also lower than that of the control (no exposure). The use of low-frequency and low-energy ultrasound in combination with microbubbles could be a potent physical method of increasing drug/gene delivery efficiency. This technique is a promising nonviral approach that can be used in cardiovascular disease therapy. (Keyword) Cell Movement / Cell Survival / Cells, Cultured / Contrast Media / Drug Delivery Systems / Endothelial Cells / Humans / Microbubbles / Phospholipids / Sulfur Hexafluoride / Transfection / Ultrasonics / Umbilical Veins (Link to Publication Site) ● Publication site (DOI): 10.1038/aps.2010.21 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20348943 ● Search Scopus @ Elsevier (PMID): 20348943 ● Search Scopus @ Elsevier (DOI): 10.1038/aps.2010.21 (DOI: 10.1038/aps.2010.21, PubMed: 20348943)
46.	Hong Yang, Hirokazu Miyoshi, ChangChun Lou, ZhengLong Ren and Yiyao Liu : Preparation, characterization and release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA, Chinese Science Bulletin, Vol.55, No.3, 263-267, 2010. (Link to Publication Site) ● Publication site (DOI): 10.1007/s11434-009-0561-0 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s11434-009-0561-0 (DOI: 10.1007/s11434-009-0561-0)
47.	Hirokazu Miyoshi, Hiroyoshi Imura and Michihiro Nakamura : Control of emission peaks of X-ray phosphor using dye-silica nanoparticles, Journal of Luminescence, Vol.130, No.3, 404-410, 2010. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jlumin.2009.10.004 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jlumin.2009.10.004 (DOI: 10.1016/j.jlumin.2009.10.004)
48.	Hirokazu Miyoshi, Matsuo Yuki, Liu Yiyao, Sakata Takao and Mori Hirotaro : Behavior of fluorescent molecules bound to the interior of silica nanoparticles in various solvents, Journal of Colloid and Interface Science, Vol.331, No.2, 507-513, 2009. (Summary) Porous silica nanocapsules with 20% 3-aminopropyltrimethoxysilane (APS)-bound 6-carboxy-fluorescein (APS-fluorescein) and 80% APS molecules adsorbed on the surface of a 50-nm-diameter Au core were prepared by a modified core-shell method. Silica mesoporous nanocapsules were obtained after the Au cores were dissolved in sodium cyanide. The size of the pores in the silica shells corresponded to the area of the fluorescein (approximately 1.02 nm(2)) in each APS-fluorescein molecule, which was bound to the silica shell by coupling between the silanol groups of APS in the APS-fluorescein molecule and the silica shell. The amino group of APS bound to the silica inside the shell is also reactive. Dy485XL N-hydroxysuccinimide ester (NHS) molecules were then added to the mesoporous silica nanocapsules in the solution and bonded to the amino group of the interior. Thus, mesoporous (fluorescein and Dy485XL)-bound silica nanocapsules were obtained. The fluorescence of Dy485XL was only observed in the mesoporous (fluorescein and Dy485XL)-bound silica nanocapsules in aqueous solution after ultrafiltration. However, the fluorescence of fluorescein reappeared after the addition of acetonitrile. Furthermore, upon adding various solvents to the mesoporous (fluorescein and Dy485XL)-bound silica nanocapsules, their fluorescence varied with that of fluorescein or Dy485XL. In the case of a mixture of 6-carboxy-fluorescein-N-hydroxysuccinimide (FLUOS) and Dy485XL-NHS free molecules in aqueous solution, the fluorescence of FLUOS was observed. Such different fluorescence phenomena demonstrated that Dy485XL-NHS molecules can easily penetrate into the nanocapsule interior via the pores and that the interior of the silica nanocapsules can bind to Dy485XL molecules. These fluorescence behaviors are discussed in terms of fluorescence resonance energy transfer (FRET) and solvatochromism. (Keyword) Fluorescent Dyes / Nanocapsules / Silicon Dioxide / Solvents (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcis.2008.09.026 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19136121 ● Search Scopus @ Elsevier (PMID): 19136121 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcis.2008.09.026 (DOI: 10.1016/j.jcis.2008.09.026, PubMed: 19136121)
49.	Hong Yang, Kai Li, Yiyao Liu, Zhonghua Liu and Hirokazu Miyoshi : Poly(D,L-lactide-co-glycolide) Nanoparticles Encapsulated Fluorescent Isothiocyanate and Paclitaxol: Preparation, Release Kinetics and Anticancer Effect, Journal of Nanoscience and Nanotechnology, Vol.9, No.1, 282-287, 2009. (Summary) Poly(D,L-lactide-co-glycolide) (PLGA) is a biodegradable and biocompatible polymer material for drug deliver system. The aim of this study is to synthesize drug-loaded PLGA nanoparticles for sustained release and its anticancer effect in vitro. PLGA nanoparticles were prepared with modified solvent evaporation method. PLGA nanoparticles encapsulated fluorescent isothiocyanate (FITC, as a model drug) and paclitaxol (therapeutic drug) were prepared with the diameter of within 800 nm as drug carrier. The release kinetics and anticancer effect for HeLa cells of the PLGA nanoparticles were further investigated. There was a peak of accumulative FITC release from the FITC-loaded PLGA nanoparticles at approximate 18 h. The inhibition rate of HeLa cell growth was studied by 3-(4,5-dimethylthiazol-2-yl)-3,5-diphenyltetrazolium (MTT) colorimetric assay. Cells were killed by paclitaxol-loaded PLGA nanoparticles. Apoptosis of HeLa cells maybe also occurred due to the sustained release of paclitaxol from the PLGA nanoparticles, which showed that PLGA nanoparticles encapsulated paclitaxol are promising as a controlled drug delivery system in future clinic application. (Keyword) Antineoplastic Agents / Cell Survival / Delayed-Action Preparations / Diffusion / Drug Compounding / HeLa Cells / Humans / Isothiocyanates / Lactic Acid / Materials Testing / Nanoparticles / Paclitaxel / Polyglycolic Acid / Spectrometry, Fluorescence (Link to Publication Site) ● Publication site (DOI): 10.1166/jnn.2009.J065 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19441308 ● Search Scopus @ Elsevier (PMID): 19441308 ● Search Scopus @ Elsevier (DOI): 10.1166/jnn.2009.J065 (DOI: 10.1166/jnn.2009.J065, PubMed: 19441308)
50.	川口佳彦, Hirokazu Miyoshi, Takuya Saze and Shintaro Nakayama : Measurement of Spread of Tritium Using the Tritium Labeled Compound, Japanese Journal of Radiation Safety Management, Vol.7, No.1, 55-60, 2008. (Keyword) spread / tritium / imaging plate / minimum quantity / DAC (Link to Publication Site) ● Publication site (DOI): 10.11269/jjrsm2001.7.55 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205397278208 ● Search Scopus @ Elsevier (DOI): 10.11269/jjrsm2001.7.55 (DOI: 10.11269/jjrsm2001.7.55, CiNii: 1390001205397278208)
51.	Yiyao Liu and Hirokazu Miyoshi : Preparation and Characterization of Novel Drug Delivery System of Light-Sensitive Silica Nanocapsules with Thin Shells, Journal of Biomedical Nanotechnology, Vol.4, No.1, 25-32, 2008. (Keyword) Light-Sensitivity / Silica Nanocapsules / Dissolution Time Course / Shell Shrinkage / Nanocapsules (Link to Publication Site) ● Publication site (DOI): 10.1166/jbn.2008.010 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-62749156800 (DOI: 10.1166/jbn.2008.010, Elsevier: Scopus)
52.	Yiyao Liu, Hirokazu Miyoshi and Michihiro Nakamura : Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis by targeted functional nanoparticles, International Journal of Cancer, Vol.120, No.12, 2527-2537, 2007. (Summary) The diagnosis and treatment of cancer or tumor at the cellular level will be greatly improved with the development of techniques that enable the delivery of analyte probes and therapeutic agents into cells and cellular compartments. Organic and inorganic nanoparticles that interface with biological systems have recently attracted widespread interest in the fields of biology and medicine. The new term nanomedicine has been used recently. Nanoparticles are considered to have the potential as novel intravascular or cellular probes for both diagnostic (imaging) and therapeutic purposes (drug/gene delivery), which is expected to generate innovations and play a critical role in medicine. Target-specific drug/gene delivery and early diagnosis in cancer treatment is one of the priority research areas in which nanomedicine will play a vital role. Some recent breakthroughs in this field recently also proved this trend. Nanoparticles for drug delivery and imaging have gradually been developed as new modalities for cancer therapy and diagnosis. In this article, we review the significance and recent advances of gene/drug delivery to cancer cells, and the molecular imaging and diagnosis of cancer by targeted functional nanoparticles. (Keyword) Drug Delivery Systems / Humans / Models, Biological / nanomedicine / nanoparticles / Nanostructures / Neoplasms / Pharmaceutical Preparations / Quantum Dots (Link to Publication Site) ● Publication site (DOI): 10.1002/ijc.22709 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17390371 ● Search Scopus @ Elsevier (PMID): 17390371 ● Search Scopus @ Elsevier (DOI): 10.1002/ijc.22709 (DOI: 10.1002/ijc.22709, PubMed: 17390371)
53.	Yiyao Liu, Hirokazu Miyoshi and Michihiro Nakamura : Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics., Colloids and Surfaces B:Biointerfaces, Vol.58, No.2, 180-187, 2007. (Summary) Core-shell nanoparticles of Au@silica with a diameter of approximate 45-60 nm and wall thickness in range of 3-10 nm were synthesized by using 40 and 50 nm gold nanoparticles as the templates. The mesoporous particles are regulated by 3-aminopropyltrimethoxysilane addition. Hollow mesoporous silica nanocapsules (HMSNs) were prepared by using sodium cyanide to dissolve the gold cores. The characterization of Au@silica and HMSNs by transmission electronic microscope indicated that the silica shells were uniform and smooth, and also the porosity was proved by fluorescein isothiocyanate (FITC) release experiments. The ratio of hollow core to HMSNs is more than 70%. HMSNs were subsequently used as drug carrier to investigate FITC (as a model drug) release behaviors in vitro. Fluorescent spectrometry was performed to determine the release kinetics from the HMSNs. The release profiles are significantly different as compared with the control (free FITC), which show that HMSNs are good drug carriers to control drug release, and have high potential in therapeutic drugs delivery in future applications. (Keyword) Drug Delivery Systems / Fluorescein-5-isothiocyanate / Fluorescent Dyes / Nanocapsules / Silicon Dioxide (Link to Publication Site) ● Publication site (DOI): 10.1016/j.colsurfb.2007.03.005 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17420116 ● Search Scopus @ Elsevier (PMID): 17420116 ● Search Scopus @ Elsevier (DOI): 10.1016/j.colsurfb.2007.03.005 (DOI: 10.1016/j.colsurfb.2007.03.005, PubMed: 17420116)
54.	Hirokazu Miyoshi, 山本康代 and Akio Adachi : 教育訓練受講時期の教育効果に与える影響と再教育訓練内容の検討, Japanese Journal of Radiation Safety Management, Vol.4, No.1, 33-38, 2005. (Keyword) Radiation Safety Re-Training Course / Questions / Recognition / Education / Average Score / Interval (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205398408448 (CiNii: 1390001205398408448)
55.	Hirokazu Miyoshi, 山本康代 and Hiromu Nishitani : 教育訓練の受講回数とRI使用の有無の教育効果へ与える影響, Japanese Journal of Radiation Safety Management, Vol.3, No.1, 27-33, 2004. (Keyword) Radiation Safety Training Course / Analysis / Attendance frequency / Educational Effect (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205398396160 (CiNii: 1390001205398396160)
56.	Hirokazu Miyoshi, Hiromu Nishitani and Yasuyo Yamamoto : Webを用いた放射線業務従事者管理のためのデータ処理ソフトウエアシステムの開発, Japanese Journal of Radiation Safety Management, Vol.2, No.2, 30-37, 2003. (Link to Publication Site) ● Publication site (DOI): 10.11269/jjrsm2001.2.74 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11269/jjrsm2001.2.74 (DOI: 10.11269/jjrsm2001.2.74)
57.	Akihiro Shirai, 佐久間貴子, 青木美保, Hirokazu Miyoshi, Takuya Maeda and Hiroki Kourai : 銀担持アクリル繊維を含む抗菌紙の殺菌作用機構, Journal of Antibacterial and Antifungal Agents, Japan, Vol.31, No.4, 173-181, 2003. (Summary) 銀担持アクリル繊維とポリエステル繊維から作製したiziの抗菌特性と殺菌作用機構を検討した．iziは，病原性細菌，Legionella pneumophila Sg1 IID 5232などを含む13菌株に対して広く高い抗菌スペクトルを示した．iziの殺菌力は，食塩，ペプトン共存下で低下することを認めた．iziの殺菌化学種は，電子スピン共鳴スペクトルと，スーパーオキシドジスムターゼもしくはヨウ化カリウムのようなラジカルスカベンジャーにより活性阻害が起こることから，ヒドロキシラジカルであることを証明し，細菌細胞中で変換されたリビングラジカルが，継続的な殺菌効果を示すことを示唆した．また，細菌細胞が，iziから銀イオンを引き抜くことを示唆した． (Keyword) Silver-supported acrylic fiber / Bactericidal activity / Bactericidal chemical species / Hydroxyl radical / Quantification of silver (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853834993299712 (CiNii: 1520853834993299712)
58.	Masafumi Amano, Hiromu Nishitani, Shingo Kawano, Motokatsu Yasutomo, Hirokazu Miyoshi and Hirofumi Yagi : Patient Skin Dose in Interventional Radiology Using Radiochromic Dosimetry Film, Japanese Journal of Radiological Technology, Vol.59, No.1, 121-129, 2003. (Summary) 照射部位が多彩で，X線管-皮膚間距離が不定なIVR手技に対してX線照射により直ちに発色する感材で作られた低感度の反射型フィルムを用いた被曝線量測定について検討した結果，良好な結果が得られたので報告した． (Keyword) reflection film / entrance surface dose (ESD) / interventional radiology (IVR) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206389506048 (CiNii: 1390001206389506048)
59.	天野雅史, Hiromu Nishitani, 河野信吾, 安友基勝, Hirokazu Miyoshi and Hirofumi Yagi : X線により発色をする反射型フィルム素材を用いたIVR手技時の患者皮膚線量測定, Japanese Journal of Radiological Technology, Vol.58, No.3, 420-423, 2002. (Keyword) Reflecting-type sheet film / Entrance skin dose (ESD) / Interventional radiology (IVR) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206390012800 (CiNii: 1390001206390012800)
60.	Hirokazu Miyoshi, Asaka Tanabe, Takuya Maeda and Hiroki Kourai : Visible Light-Induced Bactericidal Species Generated From Silver-Loaded Hydrogen Zirconium Phosphate Active Against Escherichia coli K12, Biocontrol Science, Vol.6, No.2, 69-74, 2001. (Summary) 論文題目:銀担持リン酸水素ジルコニウムからの可視光で誘導される殺菌化学種，可視光照射された銀水素リン酸ジルコニウム懸濁液から生成するOHラジカルは，スピントラップ剤であるDMPOの添加によってESRで観測することができた．I-の存在下では，DMPO-OHのピークは減少してI2が生成し，それに伴って大腸菌に対して抗菌作用を示した．エタノールや2-プロパノールの存在下では，OH•と反応して生成するアルコールラジカルが，OH•よりも高い抗菌活性を示すことを明らかにした． (Link to Publication Site) ● Publication site (DOI): 10.4265/bio.6.69 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0034792434 (DOI: 10.4265/bio.6.69, Elsevier: Scopus)
61.	Hiroyoshi Imura and Hirokazu Miyoshi : X線フィルムにおけるクロスオーバ効果の増感紙からの発光波長依存性, Japanese Journal of Radiological Technology, Vol.56, No.11, 1357-1364, 2000.
62.	松本隆裕, Hirokazu Miyoshi, 佐藤一雄, 岸太郎, Tomio Yoshino and Hiromu Nishitani : Clinical Investigation of Accumulation Process of 99mTc-HMDP and -MDP in Bone, Radioisotopes, Vol.49, No.6, 292-297, 2000. (Keyword) technetium-99m / hydroxymethylene diphosphonate / methylene diphosphonate / accumulation process / blood / technetium-99m compound / radiochromatography / bone scintigraphy (Link to Publication Site) ● Publication site (DOI): 10.3769/radioisotopes.49.292 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679133489152 ● Search Scopus @ Elsevier (DOI): 10.3769/radioisotopes.49.292 (DOI: 10.3769/radioisotopes.49.292, CiNii: 1390282679133489152)
63.	Masafumi Harada, Hirokazu Miyoshi, Masaaki Uno, Toshiko Okada, Sonoka Hisaoka and Hiromu Nishitani : Neuronal impairment of adult moyamoya disease detected by quantified proton MRS and comarison with cerebral perfusion by SPECT with Tc-99m HM-PAO: A trial of clinical quantification of metabolites, Journal of Magnetic Resonance Imaging : JMRI, Vol.10, No.2, 124-129, 1999. (Summary) We evaluated neuronal impairment of adult moyamoya patients by proton magnetic resonance spectroscopy (MRS) and cerebral perfusion scintigraphy. After evaluating two methods for compensating relaxation times, we selected a long TR, short TE sequence to achieve better reproducibility. The cerebral blood flow (CBF) value was measured by scintigraphy following the method of quantification reported in the previous literature. N-acetyl aspartate (NAA) concentrations and CBFs value were decreased statistically (P < 0. 05) compared with those of the age-matched normal controls. However, the decreased rate of NAA concentration was changed more than the CBF value, and no linear correlation was found between the two values. We considered that the NAA concentration was not always correlated with that of the present cerebral perfusion. The NAA concentration showed a more dispersive distribution in patients than in controls, indicating a large individual variation in neuronal impairment. We concluded that proton MRS may provide useful information about neuronal impairment in individual patients. J. Magn. Reson Imaging 1999;10:124-129. (Keyword) Adult / analysis of variance / brain / female / Humans / Magnetic Resonance Spectroscopy / male / Middle Aged / Moyamoya Disease / Neurons / Phantoms, Imaging / Radiopharmaceuticals / Reference Values / Statistics, Nonparametric / Technetium Tc 99m Exametazime / Time Factors / Tomography, Emission-Computed, Single-Photon (Link to Publication Site) ● Publication site (DOI): 10.1002/(SICI)1522-2586(199908)10:2%3C124::AID-JMRI3%3E3.0.CO;2-T (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10441014 ● Search Scopus @ Elsevier (PMID): 10441014 ● Search Scopus @ Elsevier (DOI): 10.1002/(SICI)1522-2586(199908)10:2%3C124::AID-JMRI3%3E3.0.CO;2-T (DOI: 10.1002/(SICI)1522-2586(199908)10:2%3C124::AID-JMRI3%3E3.0.CO;2-T, PubMed: 10441014)
64.	Makarova V. Olga, Ostafin E. Agnes, Hirokazu Miyoshi, Jr. R. Norris James and Meisel Dan : Adsorption and Encapsulation of Fluorescent Probes in Nanoparticles, The Journal of Physical Chemistry B, Vol.103, No.43, 9080-9086, 1999. (Link to Publication Site) ● Publication site (DOI): 10.1021/jp9900786 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0033318239 (DOI: 10.1021/jp9900786, Elsevier: Scopus)
65.	Hirokazu Miyoshi, Hiroki Kourai and Takuya Maeda : Light-induced Formation of 2,5-Dihydroxy-p-benzoquinone from Hydroquinone in Photoirradiated Silver-loaded Zirconium Phosphate Suspension, Journal of the Chemical Society. Faraday Transactions, Vol.94, No.2, 283-287, 1998. (Summary) 論文題目:銀担持水素リン酸ジルコニウム懸濁液中で光照射下にハイドロキノンから2,5-ジヒドロキシ-p-ベンゾキノンの生成，光照射された銀水素リン酸ジルコニウム懸濁液中で生成したOHラジカルはハイドロキノン存在下で，これを酸化しさらに2個のOHラジカルが付加した2, 5-dihydroxy-p-benzoquinoneを生成することがわかった．その生成機構についてESR測定による生成ラジカルの挙動から明らかにした．
66.	Hirokazu Miyoshi, Masamitsu Ieyasu, Yoshino Tomio and Hiroki Kourai : Photochemical property and surface characterization of silver-loaded zirconium phosphate, Journal of Photochemistry and Photobiology A: Chemistry, Vol.112, No.2-3, 239-244, 1998. (Summary) 論文題目:銀担持リン酸ジルコニウムの光化学特性と表面統制解明，銀担持リン酸ジルコニウム懸濁液への光照射により活性酸素ラジカルが生成することがESR測定によりわかった．光電気化学的測定により光カソード電流が観測されたことから，同試料上での光照射による電荷分離が確認された．担持された銀はイオンとして存在し電子プールサイトとして働くことが示唆された．以上より，新規機能性材料が光照射によりOHラジカルを発生することとその試料中での銀イオンの役割を明らかにした．
67.	Hirokazu Miyoshi, Hiroki Kourai, Takuya Maeda and Yoshino Tomio : Role of Cl- adsorbed on silver-loaded zirconium phosphate for the photooxidation of OH- to OH, Journal of Photochemistry and Photobiology A: Chemistry, Vol.113, No.3, 243-250, 1998.
68.	Masafumi Harada, Hirokazu Miyoshi, Hideki Otsuka, 田岡良章, 田内美紀 and Hiromu Nishitani : Proton MR SPectroscopyの定量化における基礎的検討と慢性脳虚血性疾患に対する応用, Nippon Acta Radiologica, Vol.57, No.8, 1997.
69.	Masafumi Harada, Hirokazu Miyoshi, Hideki Otsuka, 田岡良章 and Hiromu Nishitani : Proton MRSにおける脳内代謝物の横緩和時間について-定量化に関わる要因として-, Nippon Acta Radiologica, Vol.57, No.6, 350-352, 1997.
70.	Hirokazu Miyoshi, Mitsuhiro Matsumoto and Seiichi Kanda : Size Determination of Catena-m-(2, 5-dihydroxy-p-benzoquinonatonickel (II) Coordination Polymer Colloid and Its Photochemical Reaction, Journal of Colloid and Interface Science, Vol.193, No.1, 26-31, 1997.
71.	Hirokazu Miyoshi and Tomio Yoshino : Radiation induced thermoluminescence of calcium pyrophosphate powders prepared from thulium nitrate aqueous solution, Radiat. Phys. Chem, Vol.48, No.3, 315-318, 1996.
72.	Masahito Miyazaki, Toshiaki Hashimoto, Yoshihiro Yoneda, Masanobu Tayama, Masafumi Harada, Hirokazu Miyoshi, Noboru Kawano, Nobuhiro Murayama, Ikuko Kondo and Yoshihiro Kuroda : Proton magnetic resonance spectroscopy on childhood-onset dentatorubral-pallidoluysian atrophy(DRPLA), Brain & Development, Vol.18, 142-146, 1996.
73.	Masafumi Harada, Miki Tanouchi, Kaeko Arai, Hiromu Nishitani, Hirokazu Miyoshi and Toshiaki Hashimoto : Therpeutic Efficacy of A Case of Pyruvate Dehydrogenase Complex Deficiency Monitored by Localized Proton Magnetic Resonance Imaging, Magnetic Resonance Imaging, Vol.14, No.1, 129-133, 1996.
74.	Hirokazu Miyoshi, Hiroki Mihara and Seiichi Kanda : Coordination of 2,5-dihydroxy-p-benzoquinone to Ni(II) ion, Bull Chem. Soc. JPN, Vol.69, No.7, 1933-1935, 1996.
75.	Masafumi Harada, Hirokazu Miyoshi, 田内美紀, Hideki Otsuka and Hiromu Nishitani : Proton MR Spectroscopy(MRS)の定量評価の試み, Nippon Acta Radiologica, Vol.55, No.8, 1995.
76.	西山敬太郎, 川内ツルキ, 鈴木泰夫, Hiroaki Mikasa, Masafumi Harada and Hirokazu Miyoshi : 下肢疲労防止に対する弾性ストッキングの着用効果-ヒ腹筋の運動における32-PMRS-, 疲労と休養の科学, Vol.9, No.1, 87-93, 1995.
77.	Masafumi Harada, Miki Tanouchi, Hiromu Nishitani, Hirokazu Miyoshi, Kazuhiko Bandou and Seiji Kannuki : Non-invasive Characterization of Brain Tumor by in-vivo Proton Magnetic Resonance Spectroscopy, Japanese Journal of Cancer Research, Vol.86, 329-332, 1995.
78.	橋本俊顕, 田山正伸, 吉本勉, 宮崎雅仁, Masafumi Harada, Hirokazu Miyoshi, 田内美紀 and Yasuhiro Kuroda : 先天性筋緊張性ジストロフィー症の脳プロトン磁気共鳴スぺクトロスコピー, 脳と発達, Vol.27, 177-183, 1995.
79.	Tomio Yoshino, Hirokazu Miyoshi, 岸太郎, 佐藤一雄 and 松本隆裕 : 99m-Tc標識HMDPおよびMDPのヒドロキシアパタイトへの吸着, Radioisotopes, Vol.43, No.10, 609-612, 1994. (Keyword) technetium-99m / methylene diphosphate / in vitro method / hydroxyapatite / adsorption (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679129611776 (CiNii: 1390282679129611776)
80.	Masafumi Harada, Miki Tanouchi, Hirokazu Miyoshi, Hiromu Nishitani and Seiji Kannuki : Brain Asbcess Observed by Localized Proton Magnetic Resonance Spectroscopy, Magnetic Resonace Imaging, Vol.12, No.8, 1269-1274, 1994.
81.	橋本俊顕, 田山正伸, 宮崎雅仁, 藤井笑子, Masafumi Harada, Hirokazu Miyoshi, 田内美紀 and Yasuhiro Kuroda : 脳の1H-MRS, 脳と発達, Vol.26, 26-31, 1994.
82.	Hirokazu Miyoshi, Tomoyuki Moribe, Masafumi Harada and Hiromu Nishitani : Accuracy of the results measured by in vivo 1H-MRS using model solution, The Tokushima Journal of Experimental Medicine, Vol.39, No.1-2, 63-67, 1992.
83.	H. Mori, Hirokazu Miyoshi, K. Takeda, H. Yoneyama, H. Fujita, Y. Iwata, Y. Otuka and Y. Murata : TEM observation of iron oxide pillars in montmorillonite, Journal of Materials Science, Vol.27, No.12, 3197-3199, 1992. (Link to Publication Site) ● Publication site (DOI): 10.1007/BF01116010 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0000436258 (DOI: 10.1007/BF01116010, Elsevier: Scopus)
84.	Hirokazu Miyoshi, Hirotaro Mori and Hiroshi Yoneyama : Light-induced Decomposition of Saturated Carboxylic Acids on Iron Oxide-Incorporated Clay Suspended in Aqueous Solutions, Langmuir, Vol.7, No.3, 503-507, 1991. (Link to Publication Site) ● Publication site (DOI): 10.1021/la00051a015 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1021/la00051a015 (DOI: 10.1021/la00051a015)
85.	Hirokazu Miyoshi, Mikio Yamachika, Hirotaro Mori and Hiroshi Yoneyama : Photochemical Properties of PbS Microcrystallites Prepared in Nafion, Journal of the Chemical Society. Faraday Transactions, Vol.86, No.5, 815-818, 1990. (Link to Publication Site) ● Publication site (DOI): 10.1039/ft9908600815 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0001133024 (DOI: 10.1039/ft9908600815, Elsevier: Scopus)
86.	Hirokazu Miyoshi, Satoru Nippa, Hiroyuki Uchida, Hirotaro Mori and Hiroshi Yoneyama : Photochemical Properties of TiO2 Microcrystallites Prepared in Nafion.,, Bulletin of the Chemical Society of Japan, Vol.63, No.12, 3380-3384, 1990. (Link to Publication Site) ● Publication site (DOI): 10.1246/bcsj.63.3380 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1246/bcsj.63.3380 (DOI: 10.1246/bcsj.63.3380)
87.	Hirokazu Miyoshi, Koji Tanaka, Hiroyuki Uchida, Hirotaro Mori, Takao Sakata and Hiroshi Yoneyama : Photoelectrochemical Properties of Fe2O3 Microcrystallites Prepared in Nafion, Journal of Electroanalytical Chemistry, Vol.295, 71-78, 1990. (Link to Publication Site) ● Publication site (DOI): 10.1016/0022-0728(90)85006-Q (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/0022-0728(90)85006-Q (DOI: 10.1016/0022-0728(90)85006-Q)
88.	Hirokazu Miyoshi and Hiroshi Yoneyama : Photochemical Properties of Iron Oxide Incorporated in Clay Interlayers, Journal of the Chemical Society. Faraday Transactions, Vol.85, No.7, 1873-1880, 1989. (Link to Publication Site) ● Publication site (DOI): 10.1039/f19898501873 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-37049079281 (DOI: 10.1039/f19898501873, Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1.	Kato Ryo, Asanuma Kohgo, Maruno Yamada Yasuko, Hirokazu Miyoshi and Maruno Tohru : Development of a solid-state scintillator using a porous glass for detecting tritium in water, Memoirs of the Tohoku Institute of Technology., Vol.42, 13-21, 2021.
2.	Hirokazu Miyoshi, Masafumi Harada, 栗本有理, 谷恵理奈, 益成達也, 吉塚彩, 下川部力 and Hiromu Nishitani : 機能性磁気共鳴画像(FMRI)法を用いた視覚神経系の賦活に関する基礎的検討, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.7, 155-159, 1997.
3.	Hirokazu Miyoshi, 三谷浩明 and 横山武史 : 蛍光色素を塗布した蛍光体のX線誘起発光, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.6, 193-197, 1996.
4.	Hirokazu Miyoshi, 石川弘子, 浮浦紀子, 中川将人, Masafumi Harada and Hiromu Nishitani : 水溶性高分子で構造化した水に溶解した代謝物質の緩和時間変化, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.5, 115-119, 1995.
5.	Hirokazu Miyoshi, 石川弘子, 浮浦紀子 and 中川将人 : 固体線量計における相互作用断面積のESRによる検討, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.5, 121-125, 1995.
6.	Hirokazu Miyoshi, Masafumi Harada, 榎津浩人, 正岡憲治 and Hiromu Nishitani : 1H-MRSによる脳内代謝物質の内部標準としての水の有用性, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.4, 229-234, 1994.
7.	Hirokazu Miyoshi, Masafumi Harada, 大霜雄紀, 立石貴代子 and Hiromu Nishitani : モデル溶液中の脳内代謝物質と水の緩和時間の基礎的検討, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.4, 269-272, 1994.
8.	Hirokazu Miyoshi, Masafumi Harada, 川添絵美 and Hiromu Nishitani : 脳運動野における機能性MRIの基礎的検討, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.4, 273-275, 1994.
9.	竹本幸志, Hirokazu Miyoshi, Masafumi Harada and Hiromu Nishitani : 1H-MRスペクトロスコピーによる脳内代謝物質の検討, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.3, 177-182, 1993.
10.	Hirokazu Miyoshi, Takamasa Oishi and Tomio Yoshino : Evaluation of trap parameter of CaSO4:Tm TLD with TLD reader, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.2, 175-179, 1992.
11.	堀山一郎, 谷口春雄, Tomio Yoshino, Hirokazu Miyoshi and Katuhiko Noda : 四国及び周辺の温泉水中の環境放射線, Natural Science Research, Faculty of Integrated Arts and Sciences, The University of Tokushima, Vol.5, 53-58, 1992.
12.	Hirofumi Yagi, Sachiko Kawano and Hirokazu Miyoshi : ICRP Publication 57 医学系および歯学系作業者の放射線防護, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.1, 9-22, 1991.
13.	Tomio Yoshino, Hirokazu Miyoshi, 知花忠 and Katuhiko Noda : 徳島市における環境放射線, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.1, 159-163, 1991.

Academic Letter:

1.	Masafumi Harada, Hirokazu Miyoshi, Hideki Otsuka, 田岡良章 and Hiromu Nishitani : Proton MRSにおける脳内代謝物の横緩和時間について-定量化に関わる要因として-, Nippon Acta Radiologica, Vol.57, No.6, 350-352, 1997.

Review, Commentary:

1.	Y Liu, C Lou, H Yang, M Shi and Hirokazu Miyoshi : Silica Nanoparticles as Promising Drug/Gene Delivery Carriers and Fluorescent Nano-Probes: Recent Advances: Recent Advances, Current Cancer Drug Targets, Vol.11, No.2, 156-163, Feb. 2011. (Summary) The application of nanotechnology to biomedical research is expected to have a major impact leading to the development of new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is to develop safe and efficient drug/gene delivery vehicles. Research into the rational delivery and targeting of pharmaceutical, therapeutic and diagnostic agents is at the forefront of projects in nanomedicine. Silica, as a major and natural component of sand and glass, is a versatile material due to the variety of available chemical and physical modifications that are available, and recently have been widely applied in nanobiotechnology as drug/gene carriers or fluorescent nano-probes. The goal of this brief review is to illustrate selected examples of various functionalized silica nanoparticles as drug/gene delivery systems that have been applied to the arenas of human disease therapy or detection (molecular and cellular imaging). (Keyword) Animals / Drug Delivery Systems / Fluorescent Dyes / Gene Transfer Techniques / Humans / Nanomedicine / Nanoparticles / Nanotechnology / Silicon Dioxide / Surface Properties (Link to Publication Site) ● Publication site (DOI): 10.2174/156800911794328411 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21158720 ● Search Scopus @ Elsevier (PMID): 21158720 ● Search Scopus @ Elsevier (DOI): 10.2174/156800911794328411 (DOI: 10.2174/156800911794328411, PubMed: 21158720)
2.	Hirokazu Miyoshi and リューイーヤオ : Photo-shirinking Silica Nanocapsule, Chemical Industry, Vol.61, No.7, 38-43, Jul. 2010. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521417754826821120 (CiNii: 1521417754826821120)
3.	Yiyao Liu, Hirokazu Miyoshi and Michihiro Nakamura : Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery, Journal of Controlled Release, Vol.114, No.1, 89-99, May 2006. (Summary) Encapsulated gas microbubbles are well known as ultrasound contrast agents for medical ultrasound imaging. Nonetheless, not only do these microbubbles help to image, but they can also be used as drug/gene carriers. The microbubbles as drug/gene carriers have an average size less than that of red blood cells, i.e. they are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field. The application of ultrasound and microbubbles to targeted drug and gene delivery has been the subject of intense experimental research. Under exposure of sufficiently high-amplitude ultrasound, these targeted microbubbles would rupture, spewing drugs or genes, which are contained in its encapsulating layer, to targeted cells or tissues. Recently, targeting ligands are attached to the surface of the microbubbles (i.e. targeted-microbubbles), which have been widely used in cardiovascular system and tumor diagnosis and therapy. In this paper, the characterization of novel targeted ultrasonic contrast agents or microbubbles and their potential applications in drug delivery or gene therapy are reviewed. (Keyword) Albumins / Animals / Drug Delivery Systems / Fluorocarbons / Genetic Therapy / Humans / Membranes, Artificial / Microbubbles / Polysaccharides / Transfection / Ultrasonics (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jconrel.2006.05.018 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16824637 ● Search Scopus @ Elsevier (PMID): 16824637 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jconrel.2006.05.018 (DOI: 10.1016/j.jconrel.2006.05.018, PubMed: 16824637)
4.	Hiromu Nishitani, Hirofumi Yagi, Hirokazu Miyoshi, Junji Ueno and 天野雅史 : IVR等における医療被曝局所皮膚累積線量の正確な測定法,記録法の開発研究, INNERVISION, Vol.19, No.7, 20, Jun. 2004.
5.	Hirokazu Miyoshi : 高輝度蛍光色素分子含有シリカナノ粒子, STEPねっとわーく, Vol.8, No.1, 4-5, Apr. 2002.

Proceeding of International Conference:

1.	Welti Sophia, Yasuda Hiroshi and Hirokazu Miyoshi : Development of a novel radiochromic gel dosimeter based on the PVA-iodine matrix for use in emergency dosimetry, 20th International Conference on Solid State Dosimetry (SSD20), Sep. 2023.
2.	Hiroshi Yasuda, Gonzales A.B. Chryzel and Hirokazu Miyoshi : Thermal effects on decolorization of the PVA-iodine complex containing silica nanoparticles, International Conference on Individual Monitoring of Ionising Radiation (IM2022) and Neutron and Ion Dosimetry Symposium (NEUDOS-14), Kraków, Poland, Apr. 2022.
3.	Tamaki Otani, Hitoshi Ikushima, Yoshimi Bando, Kenmei Kuwahara, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi : Efficacy of 18F-fluorothymidine and 18F-fluorodeoxyglucose Positron Emission Tomography in Determining a Radiotherapy Effect., Annual Congress of the European Association of Nuclear Medicine, Oct. 2021.
4.	Tamaki Otani, Hideki Otsuka, Koh Matsushita, 音見陽一, Yamato Kunikane, Shota Azane and Hirokazu Miyoshi : Possibility of Shortening Examination Time in Amyloid PET using 18F-Flutemetamol., Society of Nuclear Medicine and Molecular Imaging 2020 annual meeting, Jul. 2020.
5.	Hirokazu Miyoshi, Mami Nakamura, Akira Yumoto and Yoshinori Itsuki : Structure of scintillation paper functionalized for smear test, 15th International Conference on Scintillating Materials and their Applications, Oct. 2019.
6.	Hirokazu Miyoshi, Yoko Utsumi, Kazuo Taniguchi, Hitoshi Gotoh, Tomoya Kurata, Miyuki Wakita, Miho Sakata and Tohru Maruno : Scintillation phenomena in light-excited scintillator-silica pellets, 15th International Conference on Scintillating Materials and their Applications, Oct. 2019.
7.	Hirokazu Miyoshi, Yoko Utsumi, Kazuo Taniguchi, Hitoshi Gotoh, Tomoya Kurata, Miyuki Wakita, Miho Sakata and Tohru Maruno : Novel Mechanism of Scintillation Enhancement by LED Light using Scintillator-silica Fine Powder Pellet, 19TH INTERNATIONAL CONFERENCE ON SOLID STATE DOSIMETRY, Hiroshima, Sep. 2019.
8.	Hirokazu Miyoshi, Mami Nakamura, Akira Yumoto and Yoshinori Itsuki : Development of Noble Scintillation Paper Functionalized for Detecting β-Particles, 19TH INTERNATIONAL CONFERENCE ON SOLID STATE DOSIMETRY, Hiroshima, Sep. 2019.
9.	Hirokazu Miyoshi, Fumio Kida and HItoshi Hase : Control of X-ray Visualization Using CR-39 with Methylviologen-encapsulated Silica Nanocapsules, International Congress on Advanced Materials Sciences and Engineering, Jul. 2019.
10.	Hirokazu Miyoshi, Fumio Kida, Yoshiyasu Kawase, Kenji Yamada, Motoharu Sasaki, Hidenori Shoji and Hitoshi Hase : Emission image of X-ray-irradiated CR-39 stick doped with methylviologen-encapsulated silica nanocapsules using LED light, The Ninth International Symposium on Radiation Safety and Detection Technology (ISORD-9), 36, Nagoya, Jul. 2017.
11.	Hirokazu Miyoshi, Mitsunori Hiroura, Kazunori Tshuji, Namiko Irikura and Tamaki Otani : Newscintillation imaging material composed of fine silica powder for tritium detection, 15th International Congress of Radiation Research (ICRR 2015), Kyoto, May 2015.
12.	Hirokazu Miyoshi, Fumio Kida, Hitoshi Hase and Koichiro Tsuchiya : Silica-Nanocapsule-Doped CR-39 Fluorescent Detector for X-rays, 26th International Conference on Nuclear Tracks in Solids(ICNT-26), Kobe, Sep. 2014.
13.	Hirokazu Miyoshi, Shogo Higaki, Kazuyoshi Masumoto, Norio Nogawa, Masahiro Hirota, Makoto Yanaga, Takuya Saze and Keisuke Sueki : Removal of radioactive iodine and cesium from rainwater contaminated by Fukushima Daiichi Nuclear Accident, Oarai, Dec. 2011.
14.	Hirokazu Miyoshi and Eiji Kanezaki : Dye Encapsulated Silica Nanoparticles for Solar Cell Materials, 6th Aceanian Conference on Dye-Sensitized and Organic Solar Cells (DSC-OPV6), P079, Oct. 2011. (Keyword) nanoparticles / Solar Cell
15.	Hirokazu Miyoshi, Kensho Sakamoto, Masashi Kurashina and Eiji Kanezaki : Photo-induced Electron Accumulation of Titanium Dioxide Nanoparticle Modified Electrodes, International Conference on Advanced Materials Development and Performance 2011, Tokushima, Jul. 2011.
16.	Michihiro Nakamura, Kazunori Ishimura, Hirokazu Miyoshi and H Satake : Synthesis And Characterization Of Silica Nanoparticles With High Fluorescence, Satellite for 15th Annual Meeting of Bioimaging Society, Kyoto, Oct. 2006.
17.	Michihiro Nakamura, Kazunori Ishimura, Hirokazu Miyoshi and H Satake : Synthesis And Characterization Of Silica Nanoparticles With High Fluorescence, Particles 2006 Medical/Biochemical Diagnostic, Pharmaceutical, and Drug Delivery Application, Orlando, May 2006.
18.	Hirokazu Miyoshi : Radiation effects of bound silica nanoparticles network in water radiolysis, PACIFICHEM2005, Honolulu, Dec. 2005.
19.	Meisel Dan, Ostafin Agnes, Hirokazu Miyoshi and Zhang Z. Mark : Interfacial processes in nanobubbles and nanoballs, Pacifichem 2000 Meeting, Honolulu, Dec. 2000.
20.	Dan Meisel, Hirokazu Miyoshi, M. Treguer and Tim Schatz : Ionizing radiation effects in suspensions of nanoparticles, Pacifichem 2000 Meeting,, Honolulu, Dec. 2000.
21.	Q. Wang, Hirokazu Miyoshi and A. Ostafin : Silicate Encapsulated Enzymes, (poster) AICHE 2000 Annual Meeting, Los Angeles, CA, Nov. 2000.
22.	Hirokazu Miyoshi, Schatz Tim and Meisel Dan : Radiolytic hydrogen generation in heterogeneous systems, 219th ACS National Meeting, San Francisco, CA,, Mar. 2000.
23.	A Ostafin and Hirokazu Miyoshi : Enzyme Encapsulation in Silicate Nano-shells, 44rd Biophysical Society Annual Meeting, New Orleans Convention Center, New Orleans, LA, Feb. 2000.
24.	A Ostafin, Hirokazu Miyoshi, Dan Meisel and J Norris : Encapsulation of Molecules in Silicate Nano-shells, AICHE Annual Meeting, Wyndam Hotel, Dallas, MA, Nov. 1999.

Proceeding of Domestic Conference:

1.	Hirokazu Miyoshi and 藤原正浩 : 光熱交換効果を用いた膜蒸留と気液交換を融合したHTOのH2Oからの効率的分離, 日本アイソトープ協会第61アイソトープ・放射線研究発表会, Jul. 2024.
2.	藤原正浩 and Hirokazu Miyoshi : 膜蒸留と気液交換を応用したHTOのH2Oからの分離, 日本海水学会, Jun. 2024.
3.	Hirokazu Miyoshi and 藤原正浩 : Efficient separation of HTO from H2O by membrane distillation using gas-kiquid exchange, 日本化学会第104春季年会, Mar. 2024.
4.	Hirokazu Miyoshi and 奥野功一 : タングステン-シリカ及び金-ヨウ素-シリカナノ粒子を用いた中性子及びガンマ線混在場での速・熱中性子の選択的検出その2, 日本放射線安全管理学会第22回学術大会, Nov. 2023.
5.	Hirokazu Miyoshi and 奥野功一 : タングステン-シリカ及び金-ヨウ素-シリカナノ粒子を用いた中性子及びガンマ線混在場での速・熱中性子の選択的検出, 第4回日本保健物理学会・日本放射線安全管理学会合同大会, Nov. 2022.
6.	Tamaki Otani, Hirokazu Miyoshi, Yamato Kunikane and Shota Azane : 陽電子断層撮像装置の経年変化による定量性変動, 第4回日本保健物理学会・放射線安全管理学会合同大会, Nov. 2022.
7.	Hirokazu Miyoshi, Mami Nakamura, Tamaki Otani and Hideaki Horikawa : シンチレーションペーパーの放射能測定紙としての応用, 第3回日本放射線安全管理学会・日本保健物理学会合同大会Web開催, Dec. 2021.
8.	Hirokazu Miyoshi, 矢永誠人, 桧垣正吾 and 森一幸 : イネの成長期間中の水の放射性セシウム濃度5年間の観察, 第 19回日本放射線安全管理学会学術大会(Web開催), Dec. 2020.
9.	Hideaki Horikawa, Yoshinori Kuwahara, 合田康代, 安井栄梨, Tamaki Otani and Hirokazu Miyoshi : 非密封放射性同位元素の使用施設におけるより良い放射線安全管理の追求, 第19回日本放射線安全管理学会学術大会(Web開催), Dec. 2020.
10.	Tamaki Otani, Hitoshi Ikushima, Yoshimi Bando, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi : 放射線治療効果判定における18F-FLT PETの有効性の検討, 第60回日本核医学学術総会, Nov. 2020.
11.	Tamaki Otani, Hideki Otsuka, Yamato Kunikane, Shota Azane, 藤田明彦, Masafumi Amano, 福永有希子 and Hirokazu Miyoshi : PET, 第76回日本放射線技術学会総会学術大会, May 2020.
12.	Hirokazu Miyoshi, Tamaki Otani, Yoshinori Kuwahara, Hideaki Horikawa, 合田康代 and 安井栄梨 : 学内の放射線安全管理体制についての考察, 第2回放射線安全管理学会・日本保健物理学会合同大会, Dec. 2019.
13.	Yoshinori Kuwahara, Hirokazu Miyoshi and 合田康代 : 徳島大学における放射線業務従事者管理システムの開発(その3), 第2回日本放射線安全管理学会・日本保健物理学会合同大会, Dec. 2019.
14.	矢永誠人, 出沢良樹, Hirokazu Miyoshi, 桧垣正吾, 森一幸 and 世良耕一郎 : イネおよび田水中の微量元素のPIXE分析 (VI), 第2回放射線安全管理学会・日本保健物理学会合同大会, Dec. 2019.
15.	Tamaki Otani, 草壁翔太, Hirokazu Miyoshi and Yamato Kunikane : サイクロトロン施設における標識合成設備と排気放射能濃度の関係, 第2回放射線安全管理学会・日本保健物理学会合同大会, Dec. 2019.
16.	Hirokazu Miyoshi, 湯本明, 中村真美, 伊月義則, 吉岡歩美 and Tamaki Otani : シンチレーションペーパーのふき取り効率, 第2回日本放射線安全管理学会・日本保健物理学会合同大会, Dec. 2019.
17.	Masashi Yano, Midori Yoshida, 竹口雅代, Yoko Yamashita and Hirokazu Miyoshi : 徳島大学における複数の放射線施設の廃止に係る措置の考察, 日本放射線安全管理学会第17回学術大会, 79, Dec. 2018.
18.	Tamaki Otani, Hirokazu Miyoshi and 草壁翔太 : 自己遮蔽型サイクロトロンの運転時間と放射化物の関係性, 日本放射線安全管理学会第17回学術大会, Dec. 2018.
19.	矢永誠人, 出沢良樹, Hirokazu Miyoshi, 桧垣正吾, 森一幸 and 世良耕一郎 : イネおよび田水中の微量元素の PIXE 分析(V), 日本放射線安全管理学会第17回学術大会, Dec. 2018.
20.	Hirokazu Miyoshi, 来田文夫, 中村真美, Kenji Yamada, 川瀬祥靖, 東海林秀典 and 長谷仁 : エッチングを必要としない透明な M-CR39 による X 線の線量計測, 日本放射線安全管理学会第17回学術大会, Dec. 2018.
21.	Tamaki Otani, Hideki Otsuka, Yamato Kunikane, 高志智, 板東良太, 藤田明彦, Masafumi Amano, 福永有希子, Shota Azane and Hirokazu Miyoshi : 2. Ra-223イメージングにおける最適測定条件の検討, 第38回日本核医学技術学会総会学術大会, Nov. 2018.
22.	矢永誠人, Hirokazu Miyoshi, 桧垣正吾, 森一幸, 西澤邦秀, 後藤祥子 and 世良耕一郎 : イネおよび田水中の微量元素のPIXE分析(IV), 日本放射線安全管理学会第16回学術大会, Jun. 2017.
23.	Tamaki Otani, Hirokazu Miyoshi, 藤田明彦, Masafumi Amano, Yamato Kunikane, 福永有希子, 高志智 and 坂東良太 : 放射線検出モジュールC12137を用いたRa-223γ(X)線スペクトル解析, 日本放射線安全管理学会第16回学術大会, Jun. 2017.
24.	Tomohiko Kuwabara, Hirokazu Miyoshi, Yoko Yamashita, Tokue Kuroda, Namiko Irikura, Yoshinori Kuwahara, 安井栄梨, 合田康代 and Tamaki Otani : RI施設の排風量を担保するための簡易風量計によるドラフト風量随時測定法の検討, 日本放射線安全管理学会第16回学術大会, Jun. 2017.
25.	Yoshinori Kuwahara, 合田康代 and Hirokazu Miyoshi : 徳島大学における放射線業務従事者登録申請システムの開発(その2), 日本放射線安全管理学会第15回学術大会(岡山大学), Dec. 2016.
26.	Hirokazu Miyoshi, Mami Nakamura, 合田康代, 安井栄梨, Tamaki Otani, Namiko Irikura and Yoshinori Kuwahara : 放射線業務従事者の放射線安全の理解度とヒヤリとした事例の分析, 日本放射線安全管理学会第15回学術大会(岡山大学), Dec. 2016.
27.	Yoko Yamashita, Tokue Kuroda, Tomohiko Kuwabara, Namiko Irikura, 安井栄梨, Yoshinori Kuwahara, 合田康代, Tamaki Otani and Hirokazu Miyoshi : 非密封RI施設における排気時間の再考, 日本放射線安全管理学会第15回学術大会(岡山大学), Dec. 2016.
28.	矢永誠人, Hirokazu Miyoshi, 桧垣正吾, 森一幸, 西澤邦秀, 後藤祥子 and 世良耕一郎 : イネ及び田水中の微量元素のPIXE分析(III), 日本放射線安全管理学会第15回学術大会(岡山大学), Dec. 2016.
29.	Tamaki Otani, Hideki Otsuka, Hirokazu Miyoshi, Yoshinori Kuwahara and Namiko Irikura : 動物PET計測において遮蔽体が散乱係数に与える影響, 日本放射線安全管理学会第15回学術大会(岡山大学), Dec. 2016.
30.	Tokue Kuroda, Yoko Yamashita, Tomohiko Kuwabara, Namiko Irikura, 安井栄梨, Yoshinori Kuwahara, 合田康代, Tamaki Otani and Hirokazu Miyoshi : RI施設管理の自己点検評価への新しい試み, 平成28年度放射線安全取扱部会年次大会(鎌倉), Nov. 2016.
31.	Hirokazu Miyoshi, Masayuki Shono and Tamaki Otani : 5-FU-マルトールナノ粒子複合体の5-FU放出機構, 2016年日本化学会中国四国支部大会, 72, Nov. 2016.
32.	福田直子, 谷保康一, 竹下哲史, 三浦美和, 折田真紀子, Hirokazu Miyoshi, 桧垣正吾 and 松田尚樹 : 土壌微生物に着目した放射性セシウム挙動に関する研究, 日本放射線安全管理学会第14回学術大会, Dec. 2015.
33.	矢永誠人, Hirokazu Miyoshi, 桧垣正吾, 森一幸, 西澤邦秀, 後藤祥子 and 世良耕一郎 : イネ及び田水中の微量元素のPIXE分析(II), 日本放射線安全管理学会第14回学術大会, Dec. 2015.
34.	Namiko Irikura and Hirokazu Miyoshi : メルトオンシンチレータを用いた画像化による3H-チミジン取り込みの評価, 日本放射線安全管理学会第14回学術大会, Dec. 2015.
35.	Yoshinori Kuwahara, 合田康代 and Hirokazu Miyoshi : 徳島大学における放射線業務従事者登録申請システムの開発, 日本放射線安全管理学会第14回学術大会, Dec. 2015.
36.	Hirokazu Miyoshi, 来田文夫, Kenji Yamada and 長谷仁 : CR-39を使用した透視用X線の可視化に関する研究, 日本放射線安全管理学会第14回学術大会, Dec. 2015.
37.	松田尚樹, 鈴木啓司, 高村昇, 福田直子, 藤本登, 熊谷敦史, 菓子野元郎, 小野考二, 北実, 福徳康雄, 角山雄一, 島崎達也, 小野俊朗 and Hirokazu Miyoshi : コミュニティの参画した新しい放射線教育のための放射線指導パッケージの開発, 日本放射線安全管理学会第14回学術大会, Dec. 2015.
38.	Hirokazu Miyoshi, Masayuki Shono, shingo Imagawa, Tamaki Otani, Masashi Kurashina and Eiji Kanezaki : 細胞膜吸着性と徐放出性を有する新規マルトール-シリカナノ粒子複合体の調製, 2015日本化学会中国四国支部大会, Nov. 2015.
39.	Hirokazu Miyoshi : 水田の土壌粒子の粒径と放射能の関係並びに用水及びイネの微量元素分析と溶存放射性セシウムに関する報告, 第12回日本放射線安全管理学会6月シンポジウム, Jun. 2015.
40.	新妻章一, Hirokazu Miyoshi, Masashi Kurashina and Eiji Kanezaki : テトラヒドロキシチタン(IV)を用いて調製された酸化チタンナノ構造体の光電気化学特性, 日本化学会第95春季年会, Mar. 2015.
41.	Hirokazu Miyoshi, Tamaki Otani, Yoshinori Kuwahara, Namiko Irikura, 合田康代, 安井栄梨 and 永田基 : 放射線教育スライドのパッケージ化とその効果, 日本放射線安全管理学会第13回学術大会, 151, Dec. 2014.
42.	矢永誠人, Hirokazu Miyoshi, 桧垣正吾, 森一幸, 西澤邦秀, 後藤祥子 and 世良耕一郎 : イネおよび田水中の微量元素のPIXE分析, 日本放射線安全管理学会第13回学術大会, 135, Dec. 2014.
43.	Namiko Irikura and Hirokazu Miyoshi : メルトオンシンチレータを用いたトリチウム放射能の画像化と定量性について, 日本放射線安全管理学会第13回学術大会, 129, Dec. 2014.
44.	Tamaki Otani, Hirokazu Miyoshi, 永田基 and Hideki Otsuka : Daily-QCから得られる物理的指標値からみるPET装置の経年変化, 日本放射線安全管理学会第13回学術大会, 128, Dec. 2014.
45.	Hirokazu Miyoshi, Tamaki Otani, 永田基 and Namiko Irikura : 18-Fを用いたシリカナノ粒子水分散液における放射線化学反応の試み, 日本放射線安全管理学会第12回学術大会, Nov. 2013.
46.	Hirokazu Miyoshi, 安井栄梨, Namiko Irikura, Tamaki Otani and 永田基 : 土壌中の放射性セシウムの加水による放射能分布変化とその分析, 日本放射線安全管理学会第12回学術大会, Nov. 2013.
47.	Yoshinori Kuwahara, 佐瀬卓也, Minoru Sakama, Shintaro Nakayama and Hirokazu Miyoshi : 小型線量計を用いた汚染土壌用可搬式ベクレルモニターの開発, 日本放射線安全管理学会第12回学術大会, Nov. 2013.
48.	Namiko Irikura and Hirokazu Miyoshi : 簡便なトリチウム放射能の画像化の試み, 日本放射線安全管理学会第12回学術大会, Nov. 2013.
49.	Tamaki Otani, Hideki Otsuka, Kazuya Kondo, Hiromitsu Takizawa and Hirokazu Miyoshi : 肺癌同所移植モデルマウスの18F-FDG PET/CTイメージング, 日本放射線安全管理学会第12回学術大会, Nov. 2013.
50.	Shoichi Niizuma, Hirokazu Miyoshi, Masashi Kurashina and Eiji Kanezaki : 5CB液晶分子を内包したシリカナノカプセルの調整とその分光学特性, 日本化学会第93回春季年会, Mar. 2013.
51.	Hirokazu Miyoshi : 放射性セシウムで汚染された茶葉からのお茶の抽出と分析, 日本放射線安全管理学会第11回学術大会, Dec. 2012.
52.	Hirokazu Miyoshi : 土壌からのセシウム分離, 日本放射線安全管理学会6月シンポジウム, Jun. 2012.
53.	Takuya Saze, 松本絵里佳, Yoshinori Kuwahara, 富永浩二, Minoru Sakama, Shintaro Nakayama, Hirokazu Miyoshi and Yasuo Shinohara : 小型環境放射線モニタを用いる食品等の放射能濃度測定の試み, 日本放射線安全管理学会第10回学術大会, Dec. 2011.
54.	Yoshinori Kuwahara, 山田隆治, Takuya Saze, 篠原敏徳, 市楽輝義, Shunsuke Furutani, Shintaro Nakayama, Hirokazu Miyoshi and Yasuo Shinohara : 臨床用全自動型I-125シード放射線強度測定システム, 日本放射線安全管理学会第10回学術大会, Dec. 2011.
55.	Hirokazu Miyoshi : シリカナノ粒子を用いた雨水・土壌中からの放射性ヨウ素・セシウムの除去に関する研究, 日本放射線安全管理学会第10回学術大会, Dec. 2011.
56.	Hirokazu Miyoshi and 池田稔治 : トリチウム検出ペーパーシンチレータに関する研究, 日本放射線安全管理学会第10回学術大会, Dec. 2011.
57.	Hirokazu Miyoshi and Eiji Kanezaki : bet-線放出核種を含む酸化チタンナノ粒子修飾電極における光酸化電流に対するbeta線の効果, 2011年日本化学会西日本大会, Nov. 2011.
58.	八木隆幸, Hirokazu Miyoshi, Masashi Kurashina and Eiji Kanezaki : 酸化チタンナノ構造体の光蓄電特性に及ぼす照射光強度の効果, 2011年日本化学会西日本大会, Nov. 2011.
59.	Hirokazu Miyoshi : 福島第一原発事故によって汚染された雨水中放射性ヨウ素及び放射性セシウムの除去, 第18回中国・四国支部主任者研修会, Sep. 2011.
60.	Hirokazu Miyoshi : 放射性ヨウ素・セシウム汚染の除去方法 1)水汚染除去法, 平成23年度中部支部主任者研修会, Sep. 2011.
61.	Hirokazu Miyoshi and 桧垣正吾 : 福島第一原発事故によって汚染された雨水中放射性ヨウ素及び放射性セシウムの除去に関する中間報告, 日本放射線安全管理学会第8回JRSM6月シンポジウム, Jun. 2011.
62.	Hirokazu Miyoshi, Namiko Irikura and 佐々木雅敏 : 放射性廃棄物ドラム缶収納システムの設置とその効果, 日本放射線安全管理学会第9回学術大会(広島大学), Dec. 2010.
63.	Hirokazu Miyoshi, 池田稔治 and 小嶋崇夫 : 空気溶存水溶液における放射線誘起反応, 日本放射線安全管理学会第9回学術大会(広島大学), Dec. 2010.
64.	Hirokazu Miyoshi and 梅原孝雄 : X線安全教育用に改造したX線結晶回折装置の使用とその教育効果, 日本放射線安全管理学会第9回学術大会(広島大学), Dec. 2010.
65.	日浦宏一, Hirokazu Miyoshi, Masashi Kurashina and Eiji Kanezaki : ヨウ素分子を固定したメソポーラス酸化チタン粒子の光蓄電特性, 第29回固体・表面光化学討論会(九州大学), Nov. 2010.
66.	櫂谷繁広, 前田慎平, Hirokazu Miyoshi, Masashi Kurashina and Eiji Kanezaki : メチルビオロゲン分子を被包した酸化チタン構造体の光蓄電特性に及ぼすpHの効果, 第29回固体・表面光化学討論会(九州大学), Nov. 2010.
67.	坂本健尚, Hirokazu Miyoshi, Masashi Kurashina and Eiji Kanezaki : メチルビオロゲンを挟み込んだ酸化チタン超微粒子修飾電極の光蓄電特性, 第29回固体・表面光化学討論会(九州大学), Nov. 2010.
68.	赤松和季, Minoru Sakama, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 廣田昌大, 前田幸志 and 谷井喬 : 圧延金板とイメージングプレートを用いる中性子線の視覚化, 日本放射線安全管理学会第8回学術大会, Dec. 2009.
69.	Namiko Irikura, Yoshinori Kuwahara, Hiroshi Maezawa, Hirokazu Miyoshi, Takuya Saze, 立花さやか and 合田康代 : RI施設の改修に伴う部分的な管理区域解除の事例報告, 日本放射線安全管理学会第8回学術大会, Dec. 2009.
70.	Yoshinori Kuwahara, Shunsuke Furutani, Hiroshi Maezawa, Takuya Saze, Hirokazu Miyoshi, 川口佳彦, 黒崎裕, 木下悠亮 and Shintaro Nakayama : がん治療用I-125シード放射能自動測定システムの開発, 日本放射線安全管理学会第8回学術大会, Dec. 2009.
71.	木下悠亮, Shintaro Nakayama, Ken-Ichi Fushimi, Norihiko Koori, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 川口佳彦, Yoshinori Kuwahara, Shunsuke Furutani and 黒崎裕 : がん治療用125Iシード放射能自動測定システムの性能評価, 日本放射線安全管理学会, Dec. 2009.
72.	Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, Shunsuke Furutani, Yoshinori Kuwahara, Hiromu Nishitani, 川口佳彦, 木下悠亮 and Shintaro Nakayama : I-125シード型標準線源を用いるがん治療用密封小線源の自動定量測定, 日本放射線安全管理学会, Dec. 2009.
73.	Hirokazu Miyoshi and 池田稔治 : トリチウムβ線の簡便な検出の試み, Japanese Journal of Radiological Technology, Dec. 2009.
74.	Hirokazu Miyoshi, 合田康代, Takuya Saze, 立花さやか, Hiroshi Maezawa, Namiko Irikura and Yoshinori Kuwahara : 放射線業務におけるヒヤリとした事例-再教育訓練の効果-, Japanese Journal of Radiological Technology, Dec. 2009.
75.	Yoshinori Kuwahara, Namiko Irikura, Hiroshi Maezawa, 立花さやか, 合田康代, Hirokazu Miyoshi and Takuya Saze : ASP.NETを利用した簡易RI在庫管理ソフトウエア開発, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
76.	森脇崇, Shintaro Nakayama, Hirokazu Miyoshi, Takuya Saze, Hiroshi Maezawa and 川口佳彦 : 3H-ATPを用いたトリチウムの飛散率と総放射能の検討, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
77.	Namiko Irikura, Yoshinori Kuwahara, Hiroshi Maezawa, Takuya Saze, Hirokazu Miyoshi, 立花さやか and 合田康代 : 徳島大学におけるRI汚染の対応, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
78.	黒崎裕, Shintaro Nakayama, Ken-Ichi Fushimi, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 川口佳彦 and Shunsuke Furutani : スリットとシンチレータを用いるがん治療用I-125シード強度測定システムの実現可能性の検討, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
79.	熊井万里子, Minoru Sakama, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 谷井喬, 前田幸志, 佐藤一雄, Eiichi Honda and Hiromu Nishitani : PETサイクロトロンにおける自己遮蔽体による中性子遮蔽能の検証, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
80.	Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, Shunsuke Furutani, Hiromu Nishitani, Shintaro Nakayama, 川口佳彦, 黒崎裕, 伊藤茂樹 and 西澤邦秀 : がん治療用密封小線源におけるシードイメージング定量法の進展, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
81.	櫂谷繁広, 日浦宏一, Hirokazu Miyoshi, 片山周平, Masashi Kurashina and Eiji Kanezaki : ルテニウム錯体を内部に高密度に固定し被包した酸化チタンナノ構造体の調製, 第27回固体・表面光化学討論会, Nov. 2008.
82.	Hirokazu Miyoshi, 片山周平, Masashi Kurashina and Eiji Kanezaki : 酸化チタンナノ構造体に被包したメチルビオロゲンの光化学的挙動, 第27回固体・表面光化学討論会, Nov. 2008.
83.	片山周平, Hirokazu Miyoshi, 三谷恵理子, 坂田孝夫, 森博太郎, Masashi Kurashina and Eiji Kanezaki : 酸化チタンナノカプセルに被包された長寿命メチルビオロゲンラジカルカチオンの生成, 日本化学会第88春季年会, Mar. 2008.
84.	上野有美, Takuya Saze, 坂根仁, Yoshinori Kuwahara, Namiko Irikura, 立花さやか, Hirokazu Miyoshi, Hitoshi Kubo, Masafumi Harada and Hiroshi Maezawa : 非破壊検査手法を用いるモモ果実生理障害の観察, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
85.	Namiko Irikura, 菱本純次, 花見孝行, Takuya Saze, Hirokazu Miyoshi, Yoshinori Kuwahara and Hiroshi Maezawa : 放射性有機廃液焼却装置の運転コストについて2, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
86.	Yoshinori Kuwahara, 立花さやか, Namiko Irikura, Hirokazu Miyoshi, Takuya Saze and Hiroshi Maezawa : Excelを利用した簡易入退出管理ソフトウエアの開発, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
87.	Hirokazu Miyoshi, Namiko Irikura, Takuya Saze, Yoshinori Kuwahara and Hiroshi Maezawa : 放射線教育—親子科学教室と学校科学教室, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
88.	久保田牧子, Takuya Saze, Shunsuke Furutani, Hiromu Nishitani, 川口佳彦, 中山信太郎, Hirokazu Miyoshi, 伊藤茂樹, 西澤邦秀 and Hiroshi Maezawa : イメージングプレートによって抽出されたI-125線源像のコリメータによる変化, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
89.	Hirokazu Miyoshi and Hiroyoshi Imura : ナノ粒子によるX線の着色に関する研究, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
90.	谷井喬, Takuya Saze, Minoru Sakama, 坂根仁, 前田幸志, 佐藤一雄, 川口佳彦, Hirokazu Miyoshi, Hiromu Nishitani and Hiroshi Maezawa : 自己遮蔽型PETサイクロトロンに対する中性子漏洩管理, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
91.	Hirokazu Miyoshi, 立花さやか, Takuya Saze, Namiko Irikura, Yoshinori Kuwahara, Akio Adachi and Hiroshi Maezawa : コース別再教育訓練の計画と実施及びその分析続報, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
92.	川口佳彦, Hirokazu Miyoshi, Shintaro Nakayama and 佐瀬卓也 : トリチウム標識化合物を用いたトリチウム飛散測定, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
93.	計盛祐子, Hirokazu Miyoshi, Shintaro Nakayama and Ken-Ichi Fushimi : 放射性同位元素のナノ粒子中への固定とその特性, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
94.	Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 久保田牧子, 古谷俊介, Hiromu Nishitani, 川口佳彦, 伊藤茂樹 and 西澤邦秀 : 滅菌カートリッジに封入されたがん治療用線源の簡便な品質管理, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
95.	計盛祐子, Hirokazu Miyoshi, 中山信太郎 and 伏見賢一 : 放射性同位元素のナノ粒子中への固定とその特性, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
96.	川口佳彦, 中山信太郎, Hirokazu Miyoshi and Takuya Saze : トリチウム標識化合物を用いたトリチウム飛散測定, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
97.	Hirokazu Miyoshi and 池田稔治 : ナノ粒子を用いたラジオクロミック材料の研究, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
98.	片山周平, 三谷恵理子, Hirokazu Miyoshi, 坂田孝夫, 森博太郎, Masashi Kurashina and Eiji Kanezaki : 酸化チタンナノカプセルに被包したメチルビオロゲンの光化学, 2007年日本化学会西日本大会, Nov. 2007.
99.	川口佳彦, Hirokazu Miyoshi, Takuya Saze, Shintaro Nakayama, Ken-Ichi Fushimi, Norihiko Koori, Namiko Irikura and Hiroshi Maezawa : イメージングプレートを使用したトリチウム飛散分布の画像化, 第44回アイソトープ・放射線研究発表会, Jul. 2007.
100.	Hirokazu Miyoshi, 片山周平, Masashi Kurashina and Eiji Kanezaki : 酸化チタンナノカプセルの調製と光化学特性, 日本化学会第87春季年会, Mar. 2007.
101.	Takuya Saze, 本田朋子, 前田恵理子, Masafumi Harada, Hitoshi Kubo, Hirokazu Miyoshi and Hiroshi Maezawa : 非破壊検査手法を用いる病変モモ果実の検出, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
102.	Yoshinori Kuwahara, 立花さやか, Namiko Irikura, Hirokazu Miyoshi, Takuya Saze, Hiroshi Maezawa and Akio Adachi : 払い出しから引き渡しまでの管理ソフトウエアの開発, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
103.	Namiko Irikura, Hirokazu Miyoshi, Takuya Saze, Yoshinori Kuwahara, 立花さやか, 合田康代, Akio Adachi and Hiroshi Maezawa : 管理区域における労働安全衛生法への対応, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
104.	Hirokazu Miyoshi, 合田康代, Takuya Saze, Namiko Irikura, Yoshinori Kuwahara and Hiroshi Maezawa : コース別再教育訓練の計画と実施及びその分析, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
105.	川口佳彦, Namiko Irikura, Takuya Saze, Shintaro Nakayama, Ken-Ichi Fushimi, Hirokazu Miyoshi and Hiroshi Maezawa : モデルルームを用いたトリチウムの飛散率・壁面分布測定, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
106.	Takuya Saze, 前田恵理子, Minoru Sakama, 坂根仁, 前田幸志, 佐藤一雄, 本田朋子, 川口佳彦, Hirokazu Miyoshi, Hiromu Nishitani and Hiroshi Maezawa : 自己遮蔽型PETサイクロトロンに対する中性子漏洩管理, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
107.	Takuya Saze, Shunsuke Furutani, 伊藤茂樹, 出路静彦, 廣田昌大, 有賀英司, Hirokazu Miyoshi, Hiromu Nishitani, 西澤邦秀 and Hiroshi Maezawa : イメージングプレートを用いる前立腺がん治療用線源の品質管理測定(II), 日本放射線安全管理学会第5回学術大会, Nov. 2006.
108.	Hirokazu Miyoshi, Namiko Irikura, Takuya Saze, Yoshinori Kuwahara, 合田康代, 立花さやか, Akio Adachi and Hiroshi Maezawa : 定期検査・定期確認の事例-徳島大学アイソトープ総合センター-, 日本アイソトープ協会, Nov. 2006.
109.	Michihiro Nakamura, Kazunori Ishimura, Hirokazu Miyoshi and 佐竹弘 : 蛍光色素含有ナノシリカ粒子の作製と評価, 第15回日本バイオイメージング学会学術集会, Oct. 2006.
110.	Michihiro Nakamura, Kazunori Ishimura, Hirokazu Miyoshi and 佐竹弘 : 蛍光色素含有ナノシリカ粒子の作製と評価, ナノ学会第4回大会, May 2006.
111.	Yoshinori Kuwahara, 圓藤紀子, Namiko Irikura, Hirokazu Miyoshi, Takuya Saze and Akio Adachi : RIの入庫から廃棄までの管理ソフトの開発, 日本放射線安全管理学会, Nov. 2005.
112.	Namiko Irikura, 菱本純次, 花見孝行, Yoshinori Kuwahara, Hirokazu Miyoshi, Takuya Saze and Akio Adachi : 放射性有機廃液焼却装置運転のコストについて, Nov. 2005.
113.	Namiko Irikura, 圓藤紀子, Yoshinori Kuwahara, Akio Adachi, Hirokazu Miyoshi and Takuya Saze : RI施設のオリエンテーションについて, Nov. 2005.
114.	Hirokazu Miyoshi, 圓藤紀子, Namiko Irikura, Yoshinori Kuwahara, Takuya Saze, 山本康代 and Akio Adachi : RI施設の運営状況-徳島大学アイソトープ総合センター-, 日本放射線安全管理学会, Nov. 2005.
115.	Hirokazu Miyoshi : シリカナノ粒子のネットワーク構造化と放射線照射効果, 第41回理工学における同位元素·放射線研究発表会, Jul. 2004.
116.	Namiko Irikura, Yoshinori Kuwahara, 山本康代, 圓藤紀子, Takuya Saze, Hirokazu Miyoshi and Akio Adachi : 徳島大学における作業環境測定, Jan. 2004.
117.	山本康代, Hirokazu Miyoshi and Hiromu Nishitani : 教育訓練の受講回数と教育効果の分析, 日本放射線安全管理学会第2回学術大会, Dec. 2003.
118.	天野雅史, Hiromu Nishitani, 河野信吾, 安友基勝, Hirofumi Yagi and Hirokazu Miyoshi : 反射型フィルムを用いた医療被曝評価の試み, 日本放射線安全管理学会第1回学術大会, Dec. 2002.
119.	Hirokazu Miyoshi, Hiromu Nishitani, 山本康代 and 上田崇文 : Webを用いた放射線業務従事者管理の試み, 日本放射線安全管理学会第1回学術大会, Dec. 2002.
120.	Hirokazu Miyoshi, Hiromu Nishitani, Akio Adachi, 佐藤晃一, Tokue Kuroda, 長谷川豊司, Akemi Matsushima and Yousuke Takahama : 放射能デモンストレーションキットを用いた教育訓練の実施, 日本放射線安全管理学会第1回学術大会, Dec. 2002.
121.	Hirokazu Miyoshi and Dan Meisel : シリカナノバブル中のメチルビオロゲンラジカルの放射線分解的生成, 日本化学会第81春季年会, Mar. 2002.
122.	佐久間貴子, Takuya Maeda, 高麗寛樹, 黒田保, 濱義昭, 中秀雄 and Hirokazu Miyoshi : 銀担持アクリル繊維混抄紙の殺菌メカニズム, 日本防菌防黴学会第28回年次大会, May 2001.
123.	Hiroyoshi Imura, 青山智, 中尾研一 and Hirokazu Miyoshi : X線フィルムにおけるクロスオーバ効果の波長依存性, 日本放射線技術学会第55回総会学術大会, Apr. 1999.
124.	Hiroyoshi Imura, 青山智, 中尾研一 and Hirokazu Miyoshi : レギュラーフィルムにおけるクロスオーバ効果の波長依存性, 日本放射線技術学会第39回中国·四国部会学術大会, Oct. 1998.
125.	Hirokazu Miyoshi, 柴田進次, 金崎英二 and Hiroyoshi Imura : X線励起蛍光を紫外部に有するユーロピウム付活BaSO4の物性, 日本化学会第47回春季年会, Mar. 1998.

Et cetera, Workshop:

1.	Hirokazu Miyoshi : 徳島大学放射線総合センターの放射線安全管理におけるRI関連提出書類のペーパーレス化, 北陸地域アイソトープ研究会放射線取扱技術研修会, Mar. 2024.
2.	Hirokazu Miyoshi : ヒヤリハットの事例から考える放射線安全管理, 令和5年度愛媛大学定期放射線教育・訓練及び放射線安全管理に関する講演, Feb. 2024.
3.	Hirokazu Miyoshi : RI 施設の``終末''から日頃の管理に生かすこと, 令和4年度放射線安全管理講習会, Dec. 2022.
4.	Hirokazu Miyoshi : シリーズ:「知識の伝承」をサイエンスする第 3 回 RI 施設の終末をどうするか, ISOTOPE NEWS, Vol.6, No.775, 92-96, Jun. 2021.
5.	Hirokazu Miyoshi : シンチレータ-シリカペレットの励起状態でのトリチウムβ線に対するシンチレータ特性, SMART2019, Nov. 2019.
6.	Hirokazu Miyoshi : 放射線安全管理 –ヒヤリとした事例の分析から–, 日本核医学技術学会第29回中国・四国地方会, Jun. 2017.
7.	Hirokazu Miyoshi, Eiichi Honda, Ken-Ichi Fushimi, Takuya Saze, 蕪木宏行, 森谷洋治, 小西憲治, Hideki Otsuka, Shunsuke Furutani, Yasuhiko Morita, Seiji Iwamoto, 川口和雅, Hitoshi Kubo, 多田章久, Yoshinori Kuwahara, Namiko Irikura, 合田康代 and 大東のぞみ : 徳島大学アイソトープ総合センターニュース, 徳島大学アイソトープ総合センターニュース, No.9, 1-40, Feb. 2012.
8.	Hirokazu Miyoshi : 自然放射線と放射線防護で使用する用語について, 平成23年度徳島電気技術協会記念講演, May 2011.
9.	Hirokazu Miyoshi : ナノサイズのシリカ粒子の可能性∼蛍光色素から放射性同位元素まで∼, 第5回徳島大学研究者との集い~医療を牽引する技術を創出する研究者達の素顔~, Feb. 2011.
10.	Hirokazu Miyoshi : 徳島大学アイソトープ総合センター, 日本放射線安全管理学会誌, Vol.9, No.1, 69-70, Jun. 2010.
11.	Hirokazu Miyoshi : 光で収縮するシリカナノカプセル, 四国地区四大学新技術説明会, Apr. 2010.
12.	Hirokazu Miyoshi, Yasuo Shinohara, Takuya Saze, Yasuhiko Morita, 鬼島明洋, Seiji Iwamoto, Eiichi Honda, Hideki Otsuka, 佐藤一雄, Namiko Irikura, Yoshinori Kuwahara, 合田康代 and 立花さやか : 徳島大学アイソトープ総合センターニュース, 徳島大学アイソトープ総合センターニュース, No.8, 1-46, Feb. 2010.
13.	Hirokazu Miyoshi : 放射線量の測定技術, 四国地区四大学研究発表会 JST Innovation Bridge, Oct. 2009.
14.	Hirokazu Miyoshi : 放射線管理において留意すべき事項, 日本核医学技術学会中国・四国地方会, Vol.19, 30-31, Sep. 2009.
15.	Hirokazu Miyoshi, Hiroshi Maezawa, Yoshinori Kuwahara, Takuya Saze, 松田尚樹, 蕪木宏行, Yasuhiko Morita, Seiji Iwamoto, Hideki Otsuka, 佐藤一雄, Eiichi Honda, Namiko Irikura, 合田康代 and 立花さやか : 徳島大学アイソトープ総合センター, 徳島大学アイソトープ総合センター, No.7, 1-44, Aug. 2008.
16.	Hirokazu Miyoshi and 佐藤一雄 : 放射線業務従事者教育訓練ノート, 放射線業務従事者教育訓練ノート, Apr. 2007.
17.	Hirokazu Miyoshi : 放射線業務従事者教育訓練ノート, Apr. 2007.
18.	Hirokazu Miyoshi : 放射線業務従事者教育訓練ノート, 放射線業務従事者教育訓練ノート, 1-42, Apr. 2007.
19.	Hirokazu Miyoshi, Hiroshi Maezawa, Takuya Saze, Yoshinori Kuwahara, Namiko Irikura, 立花さやか and Akio Adachi : 徳島大学アイソトープ総合センター概要2007年度版, Apr. 2007.
20.	Hirokazu Miyoshi, Hiroshi Maezawa, Akio Adachi, Takuya Saze, Namiko Irikura, Yoshinori Kuwahara, 立花さやか, Tatsuhiro Ishida, Akihiko Tsuji, Takao Hanabusa, Toshihiro Moriga, 鬼島明洋, Eiichi Honda, Seiji Iwamoto, 佐藤一雄, Shunsuke Furutani and Yasuhiko Morita : 徳島大学アイソトープ総合センターニュース, 徳島大学アイソトープ総合センターニュース, Vol.6, 1-42, Mar. 2007.
21.	川口佳彦, Hirokazu Miyoshi, Takuya Saze, Namiko Irikura, Shintaro Nakayama, Norihiko Koori, Ken-Ichi Fushimi and Hiroshi Maezawa : イメージングプレートを使用したトリチウム飛散測定の画像化, 弥生研究会「放射線検出器とその応用」プログラム, Feb. 2007.
22.	Yoshiko Kawaguchi, Shintaro Nakayama, Ken-Ichi Fushimi, Norihiko Koori, Hirokazu Miyoshi, Takuya Saze, Namiko Irikura and Hiroshi Maezawa : Spread of Tritium Distribution in the Model Room Obtained using Imaging Plate, KEK Proceedings, 2007.
23.	Hirokazu Miyoshi, 佐藤晃一 and 合田康代 : 放射線業務従事者等の登録と手引き2006, Apr. 2006.
24.	Hirokazu Miyoshi : Guide for Radiation Workers 2005, Guide for Radiation Workers 2005, Apr. 2005.

Report:

1.	Hirokazu Miyoshi : シリカナノカプセル内の液晶のTEM観察, 阪大複合機能ナノファウンダリ研究報告書, Vol.5, 161-162, Apr. 2012.
2.	Hirokazu Miyoshi : γ線照射によるシリカナノ粒子表面に析出した銀微粒子のTEM像, 阪大複合機能ナノファウンダリ研究報告書, Vol.4, 82-83, Apr. 2011.
3.	Hirokazu Miyoshi : ナノシリカ粒子を用いた放射性同位元素安全使用のための基礎的な研究, 平成21年度科学研究補助金「挑戦的萌芽研究」実績報告書, Apr. 2010.
4.	Hirokazu Miyoshi : モンモリロナイト粘土上に調製した銀ナノ粒子のHREM像, 阪大複合機能ナノファウンダリ研究報告書, Vol.3, 89-90, Apr. 2010.
5.	Hirokazu Miyoshi and 池田稔治 : シリカナノ粒子を用いた放射線効果の研究とその効果を利用した新規ラジオクロミック材料の研究と開発, 量子ビーム科学研究施設平成21年度報告書, 71, Apr. 2010.
6.	Hirokazu Miyoshi : 銅微粒子をコアとして色素を被包して調製した色素―銅微粒子―シリカシェルのHREM観察, 阪大複合機能ナノファウンダリ研究成果報告書, Vol.2, 100-101, Apr. 2009.
7.	Hirokazu Miyoshi : 平成20年度科学研究費補助金「挑戦的萌芽研究」実績報告書, Apr. 2009.
8.	Hirokazu Miyoshi and 四国TLO : 平成20年度エコイノベーション推進事業「機能性シリカ粒子を使った色素増感型太陽電池材料の開発」調査委託成果報告書, 平成20年度成果報告書, 1-59, Apr. 2009.
9.	Hirokazu Miyoshi and 池田稔治 : シリカナノ粒子を用いた放射線効果の研究とその効果を利用した新規ラジオクロミック材料の研究と開発, 加速器量子ビーム実験室平成20年度報告書, 66, Apr. 2009.
10.	Hirokazu Miyoshi and 坂本健尚 : ナノ構造体に関する研究2, 平成20年度共同研究報告書, 1-7, Feb. 2009.
11.	Hirokazu Miyoshi, 松尾侑季, 計盛祐子 and Liu Yiyao : ナノ構造体に関する研究, 共同研究報告書, 1-7, Apr. 2008.
12.	Hirokazu Miyoshi : ナノシリカ粒子を用いた放射性同位元素安全使用のための基礎的な研究, 平成19年度科学研究費補助金「萌芽研究」実績報告書, Apr. 2008.
13.	Hirokazu Miyoshi : 内部に有機分子を有する酸化チタンナノカプセル及びシリカナノカプセルの形態観察, 阪大複合機能ナノファウンダリ研究成果報告書, Vol.1, 96-97, Apr. 2008.
14.	Hirokazu Miyoshi, Takuya Saze, Yoshinori Kuwahara, Namiko Irikura and Hiroshi Maezawa : ファミリーサイエンス教室(あすたむらんど徳島), 平成19年度地域連携事業成果報告書, 28, Mar. 2008.
15.	Hirokazu Miyoshi : 低線量放射線変色紙に関する研究平成14年度∼平成18年度, 共同研究報告書, 1-23, Apr. 2007.
16.	Hirokazu Miyoshi and 池田稔治 : Study on new radiochromic materials by using radiation, 加速器量子ビーム実験室平成19年度報告書, 73-74, 大阪大学産業科学研究所産業科学ナノテクノロジーセンター加速器量子ビーム実験室, Mar. 2007.
17.	Hirokazu Miyoshi and Yiyao Liu : HREM Observation of the silica layer with nano capsules, 文部科学省ナノテクノロジー総合支援プロジェクト材料・生体ナノ構造解析支援実績報告書, 105-106, 大阪大学超高圧電子顕微鏡センター, Mar. 2006.
18.	Namiko Irikura, 立花さやか, Yoshinori Kuwahara, Hirokazu Miyoshi, 合田康代 and Takuya Saze : 徳島大学アイソトープ総合センター概要, 徳島大学アイソトープ総合センター概要, 1-53, Tokushima, Apr. 2005.
19.	Hirokazu Miyoshi : シリカナノ粒子によるネットワーク構造化と放射線照射に対する効果に関する研究, 第28回黎明研究課題報告書, Jun. 2004.
20.	Masayuki Shibuya, Hiroshi Kido, Yoshio Hayashi, Hisao Nemoto, Shigeki Sano, Koji Yasutomo, Hiroyuki Azuma, Yasuhiko Nishioka, Junji Terao, Takeshi Nikawa, Hiroaki Misawa, Shigeki Matsuo, Yoshinobu Baba, Kozo Matsumoto, Hirokazu Miyoshi and Saburo Sone : 徳島大学先端医療開発研究センター設置準備室成果報告書, Dec. 2002.

Patent:

1.	Hirokazu Miyoshi and Michihiro Nakamura : 標識分子含有シリカ球の調製方法, 2004-356608, .
2.	Hirokazu Miyoshi and Hiroyoshi Imura : X線増感紙に関する発明, 2005-82463, .
3.	Hirokazu Miyoshi and 大野法行 : 放射性着色性物質, 2004-190421, .
4.	Hirokazu Miyoshi : 色材組成物及びそれを含有する発色または発光性製品, 2005-082289, 4774507.
5.	Hirokazu Miyoshi : 機能性シリカ粒子及びその用途, 2006-528665, 4820963.
6.	Aizawa Hideki, Ohkubo Michio, Michihiro Nakamura and Hirokazu Miyoshi : System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination., 8,796,040 (Aug. 2014).
7.	Hirokazu Miyoshi and Michihiro Nakamura : 標識分子含有シリカ球の調製方法, 2005-82289, 4982687 (May 2012).
8.	Hirokazu Miyoshi : 色材組成物及びそれを含有する発色または発光性製品, 2005-82289, 4774507 (Mar. 2005).
9.	吉岡歩美 and Hirokazu Miyoshi : 放射線検出フィルム及びその製造方法, 2020-209789 (Dec. 2020), .
10.	湯本明 and Hirokazu Miyoshi : 放射線検出粉末とその製造方法，及び放射線検出粉末を備える放射線検査紙とその製造方法, 2019-109036 (Jun. 2019), 7295514 (Jun. 2023).
11.	Hirokazu Miyoshi, 後藤仁 and 山中佑充 : シンチレーション光増幅容器，及び放射線検出装置, - (Oct. 2016), .
12.	Hirokazu Miyoshi : シンチレータ固定化ケイ酸粒子, 2015-090939 (Apr. 2015), 6590185 (Sep. 2019).
13.	Hirokazu Miyoshi, 前田淳 and 益子裕伎 : 放射線感知材料, (Sep. 2014), 2014-189750 (Sep. 2014).
14.	Masayuki Shono and Hirokazu Miyoshi : ナノファイバーのコーティングシートとこのコーティングシートの検査方法, 2014-163236 (Aug. 2014), 6342261 (May 2018).
15.	Hirokazu Miyoshi, 長谷仁 and 来田文夫 : エックス線検出具及びエックス線検出方法, (Oct. 2013), 2013-223468 (Oct. 2013).
16.	清水洋, 藤原正浩 and Hirokazu Miyoshi : 「液晶分散シリカナノ粒子」(ストーバー法), 2010-227564 (Oct. 2010), .
17.	清水洋, 藤原正浩 and Hirokazu Miyoshi : 「液晶含有シリカナノ粒子」(コアシェル法), 2010-227564 (Oct. 2010), .
18.	Hirokazu Miyoshi and Liu Yiyao : SILICA NANOCAPSULE, (Oct. 2008), PCT/JP2008/069976 (Oct. 2008).
19.	Hirokazu Miyoshi and Yiyao Liu : シリカナノカプセル, 2009-539417 (Oct. 2008), .
20.	Hirokazu Miyoshi and Hiroyoshi Imura : 蛍光材料及びX線増感基板, 2006-79162 (Mar. 2006), 4759741 (Mar. 2006).
21.	古河電工株式会社, Michihiro Nakamura and Hirokazu Miyoshi : フローサイトメーターによる生体分子の定量システム，その定量方法，細胞の検出・分取システム，その検出・分取方法，それらに用いる蛍光シリカ粒子，及び複数個の蛍光シリカ粒子を組み合わせたキット, 2006-049303 (Feb. 2006), .
22.	古河電工株式会社, Michihiro Nakamura and Hirokazu Miyoshi : ナノシリカ粒子，それを用いたバイオチップ及びそのアッセイ法, 2005-376401 (Dec. 2005), .
23.	古河電工株式会社, Michihiro Nakamura and Hirokazu Miyoshi : 蛍光ナノシリカ粒子，ナノ蛍光材料，それを用いたバイオチップ及びそのアッセイ法, 2005-376401 (Dec. 2005), .
24.	Hirokazu Miyoshi : シリカ粒子を含有する放射線感光性色素組成物の10Gy以下の低線量の放射線の測定への使用, 2004-190421 (Jun. 2004), 2006- (2006), 4586191 (Sep. 2010).
25.	Hirokazu Miyoshi and Hiroki Kourai : ヒドロキシル化反応触媒及びこれを用いるヒドロキシル基含有化合物の製造方法, 9-304848 (Oct. 1997), 11-123332 (May 1999), .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Study on effective separation of HTO from H2O which fused with adsorption and rectification by membrane distillation (Project/Area Number: 22K19870 )
Creation of Radiation Science Culture with High Robustness - A New Horizon of Radiation Learning (Project/Area Number: 16H03062 )
Development of instruction packages for new radiation education associated with the community (Project/Area Number: 25282042 )
Studies on liquid crystal encapsulated silica nanoparticles (Project/Area Number: 23651123 )
Studies on effective use of β-ray emitter fixed in titanium dioxide nanoparticles (Project/Area Number: 22656186 )
Evaluation of nanoparticles exposure from surrounding environment and study on their disposition (Project/Area Number: 21360253 )
ナノシリカ粒子を用いた放射性同位元素安全使用のための基礎的な研究 (Project/Area Number: 19651022 )
Development of accurate measurement and recording system for the measurement of regional accumulated skin dose to patients during IVR, procedures (Project/Area Number: 14370279 )
Clinical Utility of Information of Metabolite Diffusion, Concentration and Relaxation Time Evaluated by Multiple Parametric Analysis (Project/Area Number: 10670854 )
A study of functional MRI on whole brain measured by EPI sequence (Project/Area Number: 07557069 )
A study of ^<19>F-MRI as a new imaging modality for tumor and utility on tumor therapy (Project/Area Number: 06807073 )
三酸化タングステン半導体超微粒子の放射線化学特性 (Project/Area Number: 05855125 )
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Professor : Miyoshi, Hirokazu

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)