徳島大学 / 教育研究者総覧 --- 北畑洋

個人のホームページ

https://researchmap.jp/read0017322 (researchmap)

専門分野

○	麻酔科学 (Anesthesiology)
○	歯科麻酔科学
○	循環器学 (Cardiology)

研究テーマ

○	長寿遺伝子Sirtuinの吸入麻酔薬によるプレコンディショニング作用への影響 (心筋保護 (myocardial protection), 吸入麻酔薬, サーチュイン)
○	Stroke Volume VariationやPleth Variability Indexなどを用いた循環動態の急変を予測できる動的指標に関する研究 (超音波法 (ultrasonic method), 心機能 (myocardial function), 一回拍出量変動, 脈波変動指標)
○	β遮断薬と周術期心筋虚血, 局所心筋血流分布 (心筋虚血 (myocardial ischemia), 心筋血流)

著書・論文

著書:

1.	北畑洋, 高石和美 : 第7章全身麻酔, --- 1 全身麻酔の理論 ---, 永末書店, 京都, 2021年2月.
2.	高石和美, 北畑洋 : 第7章全身麻酔, --- 2 吸入麻酔法 ---, 永末書店, 京都, 2021年2月.
3.	川人伸次, 北畑洋 : 第1章基礎・準備編, --- 1 プローブの選択と安全な挿入法 ---, 株式会社羊土社, 東京, 2020年6月.
4.	北畑洋 : 第6章全身管理上問題となる疾患の病態と患者管理 II 循環系疾患, 医歯薬出版株式会社, 東京, 2019年2月.
5.	高石和美, 北畑洋 : 第7章全身麻酔 2 吸入麻酔法, 永末書店, 京都, 2019年1月.
6.	北畑洋, 高石和美 : 第7章全身麻酔 1 全身麻酔の理論, 永末書店, 京都, 2019年1月.
7.	北畑洋 : 第2章高齢者に多い内科系疾患の歯科治療前評価と対応 1. 循環器疾患, --- (7)心臓弁膜症 (8)心筋症 ---, 2017年4月.
8.	北畑洋 : 歯科麻酔, --- 徳島大学病院の最新治療が分かる本 ---, 株式会社バリューメディカル，東京，発売:南々社，広島, 2015年8月.
9.	北畑洋, 川人伸次 : 18 小児疾患，プラダー・ウィリー症候群, --- まれな疾患の麻酔A to Z ---, 分光堂, 東京, 2015年5月.
10.	高石和美, 北畑洋 : Chapter 16 歯科治療時の緊急事態とその対応, --- 歯科医師のための医学ハンドブック ---, 医歯薬出版株式会社, 東京, 2014年5月.
11.	廣瀬佳代, 北畑洋 : Chapter 14 歯科医師に必要な検査値の読み方・活かし方, --- 歯科医師のための医学ハンドブック ---, 医歯薬出版株式会社, 東京, 2014年5月.
12.	北畑洋, 廣瀬佳代 : 1. 心臓，血管の受容体:心血管作動薬の作用点 1. 心筋細胞に存在する受容体とその作用ー心血管作動薬ー, 克誠堂出版株式会社, 東京, 2013年5月.
13.	Hiroshi Kitahata and Shinji Kawahito : Transesophageal echocardiography 2nd edition, --- Contrast Echo Method ---, 株式会社診断と治療社, Tokyo, Nov. 2012.
14.	川人伸次, 北畑洋 : 第1章基礎・準備編 1 プローブの選択と安全な挿入法ー経食道心エコー:撮り方，見かたの基本とコツ改訂新版ー, 株式会社羊土社, 東京, 2011年6月.
15.	北畑洋, 川人伸次 : 第2章全身管理の基本 Ⅲ 管理上問題となる疾患の病態 2. 循環系疾患ー歯科麻酔学第7版ー, 医歯薬出版株式会社, 東京, 2011年3月.
16.	北畑洋, 川人伸次 : 第Ⅱ章循環器「心筋梗塞の既往がある」ー麻酔科トラブルシューティング A to Zー, 文光堂, 東京, 2010年10月.
17.	大下修造, 北畑洋 : 第4章麻酔前の準備 III. 術前評価 B. 全身状態の評価, --- 麻酔実践テキスト ---, 南江堂, 東京, 2008年9月.
18.	川人伸次, 北畑洋 : 第1章基礎・準備編 1 プローブの選択と安全な挿入法, --- 経食道心エコー:撮り方，見かたの基本とコツ ---, 株式会社羊土社, 東京, 2007年9月.
19.	北畑洋 : Ⅱ. 冠動脈疾患患者の術中モニタリング 3. 経食道心エコー法の基本, --- 麻酔下診療プラクティス 10，麻酔科医に必要な冠動脈疾患の知識 ---, 文光堂, 東京, 2003年5月.
20.	北畑洋 : 第10講麻酔とモニター 2. 循環系モニター e. 経食道心エコー法(transesophageal echocardiography: TEE), --- 麻酔·蘇生学講義 ---, 克誠堂出版株式会社, 東京, 2001年10月.
21.	北畑洋, 川人伸次 : F. 内分泌 9. Prader-Willi症候群, --- 麻酔科診療プラクティス1，まれな疾患の麻酔 ---, 文光堂, 東京, 2001年4月.
22.	Hiroshi Kitahata : Part III, Chapter 21 Myocardial perfusion with contrast material, --- Transesophageal Echocardiography ---, 株式会社診断と治療社, Tokyo, Sep. 2000.
23.	北畑洋 : 術中心筋虚血の早期診断 -経食道心エコー法-, --- 術期の心筋虚血機序·予防·診断·治療 ---, 克誠堂出版株式会社, 東京, 1992年6月.
24.	丘ヤス, 北畑洋 : フォーレンの薬理 3. 循環器系, --- フォーレン麻酔の手引 ---, ダイナボット株式会社, 大阪, 1990年2月.
25.	丘ヤス, 北畑洋, I Hollinger : 各科手術のフォーレン麻酔 2. 心血管外科の麻酔, --- フォーレン麻酔の手引 ---, ダイナボット株式会社, 大阪, 1990年2月.

学術論文(審査論文):

1.	西川美佳, 高石和美, 藤原茂樹, 江口覚, 北畑洋, 川人伸次 : 歯科口腔外科手術における高齢患者の麻酔方法と術前合併疾患に関する検討, 臨床麻酔, Vol.48, No.1, 87-89, 2024年.
2.	Kazumi Takaishi, Marina Takata, Risa Aoki, Shigeki Fujiwara Joseph Luke, Shinji Kawahito and Hiroshi Kitahata : Total Intravenous Anesthesia Using Remimazolam and Continuous Cardiac Output Monitoring for Dental Anesthesia in a Patient With Takayasus Arteritis: A Case Report, A&A Practice, Vol.16, No.8, e01599, 2022. (要約) Takayasu's arteritis is a persistent chronic progressive inflammation of the large- and medium-caliber arteries. Controlling cardiovascular variability during anesthesia and overcoming difficulties of cardiovascular monitoring due to the impaired vessels are important in patients with Takayasu's arteritis. Remimazolam is a novel short-acting benzodiazepine with mild effects on hemodynamics. We report the case of a patient with Takayasu's arteritis who underwent oral surgery under general anesthesia. This report highlights the use of remimazolam and remifentanil to reduce hemodynamic perturbations using estimated continuous cardiac output monitoring. (キーワード) Anesthesia, Dental / Anesthesia, General / Anesthesia, Intravenous / Benzodiazepines / Cardiac Output / Humans / Takayasu Arteritis (出版サイトへのリンク) ● Publication site (DOI): 10.1213/XAA.0000000000001599 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35952326 ● Summary page in Scopus @ Elsevier: 2-s2.0-85136343135 (DOI: 10.1213/XAA.0000000000001599, PubMed: 35952326, Elsevier: Scopus)
3.	Kazumi Takaishi, Shinji Kawahito and Hiroshi Kitahata : Management of a patient with tracheal stenosis after previous tracheotomy, Anesthesia Progress, Vol.68, No.4, 224-229, 2021. (要約) Tracheal stenosis after tracheotomy can cause difficult airway management and respiratory complications. It is difficult to predict tracheal stenosis after tracheotomy based on a patient's symptoms as the symptoms of tracheal stenosis appear only after they become severe. In patients with a history of previous tracheotomy, it is important to consider the risk factors for tracheal stenosis. Detailed preoperative evaluation of patients with a history of previous tracheotomy is essential and should include 3-dimensional assessment of the airway. We report the preoperative assessment and perioperative management of an 83-year-old woman at high risk for tracheal stenosis due to a previous emergency tracheotomy who was scheduled to undergo general anesthesia for a right maxillectomy for squamous cell carcinoma. Preoperative anteroposterior chest radiograph revealed findings indicative of tracheal stenosis. Additional detailed examinations of the stenotic area were conducted with computed tomography imaging and bronchofiberscopy. General anesthesia with nasotracheal intubation was performed, and although there were no adverse intraoperative events, stridor after extubation was observed. Nebulized epinephrine was administered via an ultrasound nebulizer and effectively improved the patient's postoperative transient dyspnea. (キーワード) Aged, 80 and over / Airway Management / Female / Humans / Intubation, Intratracheal / Tracheal Stenosis / Tracheostomy / Tracheotomy (出版サイトへのリンク) ● Publication site (DOI): 10.2344/anpr-68-03-08 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34911067 ● Search Scopus @ Elsevier (PMID): 34911067 ● Search Scopus @ Elsevier (DOI): 10.2344/anpr-68-03-08 (DOI: 10.2344/anpr-68-03-08, PubMed: 34911067)
4.	Kazumi Takaishi, Ryo Otsuka, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Shinji Kawahito and Hiroshi Kitahata : A Retrospective Case Series of Anesthetic Patients With Epiglottic Cysts, Anesthesia Progress, Vol.68, No.3, 168-177, 2021. (要約) Previously undiagnosed or asymptomatic epiglottic cysts may be coincidentally detected during intubation. This retrospective case series identified undiagnosed epiglottic cysts that were discovered during intubation in 4 patients who underwent oral surgery under general anesthesia at our hospital during a 6-year period. Including 2 additional cases, 1 previously diagnosed and 1 detected during preoperative imaging, epiglottic cysts were observed in 6 of 1112 cases (0.54%) total. Among the undiagnosed epiglottic cyst cases, mild dyspnea on effort or snoring was reported in 2 patients, but all others were asymptomatic. Upon discovering previously undiagnosed epiglottic cysts during intubation, it is essential to proceed cautiously, remain alert for potential airway management difficulties, and avoid injuring or rupturing the cysts. In addition, any available preoperative imaging should be reviewed as information pertinent to the airway and any abnormalities may be useful. This report discusses the anesthetic care of 6 patients with epiglottic cysts that were previously known or initially discovered during intubation. (キーワード) Anesthetics / Cysts / Epiglottis / Humans / Intubation, Intratracheal / Retrospective Studies (出版サイトへのリンク) ● Publication site (DOI): 10.2344/anpr-68-01-01 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34606575 ● Search Scopus @ Elsevier (PMID): 34606575 ● Search Scopus @ Elsevier (DOI): 10.2344/anpr-68-01-01 (DOI: 10.2344/anpr-68-01-01, PubMed: 34606575)
5.	Tomohiro Soga, Shinji Kawahito, Naoji Mita, Shusuke Yagi, K Nitta, K Takata, Fumihiko Tada, Hiroyuki Kinoshita, Kazumi Takaishi and Hiroshi Kitahata : Viability of intensive insulin therapy during pediatric surgery, Clinical Pediatric Anesthesia, Vol.27, No.1, 3-8, 2021. (キーワード) intensive insulin therapy / pediatrics / surgery / continuous blood glucose monitoring / artificial endocrine pancreas (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520294113670277632 (CiNii: 1520294113670277632)
6.	Kazumi Takaishi, Yasusei Kudo, Shinji Kawahito and Hiroshi Kitahata : Clinically relevant concentration of propofol and benzodiazepines did not affect in vitro angiogenesis., Journal of Anesthesia, Vol.35, No.6, 870-878, 2021. (要約) Angiogenesis, one of regenerative medicine, is essential in the process of wound healing. The detailed effects of intravenous anesthetics and sedatives used during perioperative period have not yet been clarified. We investigated the effects of benzodiazepines and propofol on in vitro capillary tube formation. The effects of midazolam, diazepam and propofol (1, 10, 50 M each) on proliferation of human umbilical vein endothelial cells (HUVEC) and normal human diploid fibroblasts (NHDF) were determined. Quantitation of migration was achieved by measuring the fluorescence of migrating HUVEC using angiogenesis system. The effects of midazolam, diazepam and propofol on in vitro angiogenesis were investigated in co-cultured HUVEC and NHDF incubated. The effects of midazolam on activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases were examined by Western blot analysis using phospho-specific antibodies. Parametric data were analyzed with one-way repeated measures analysis of variance followed by the Scheff test. A value of P < 0.05 was considered statistically significant. Fifty M of midazolam significantly impaired endothelial cell proliferation, migration, and in vitro capillary tube formation. Propofol, diazepam or lower dose midazolam did not show any enhancing or suppressive effects on in vitro angiogenesis. Fifty M of midazolam remarkably activated ERK, but not p38 MAPK in HUVEC. Propofol and benzodiazepines except high-dose midazolam did not affect in vitro angiogenesis. High-dose midazolam may impair in vitro capillary tube formation due to by suppressing proliferation and migration of endothelial cells via activation of ERK. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-021-02993-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34460008 ● Search Scopus @ Elsevier (PMID): 34460008 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-021-02993-x (DOI: 10.1007/s00540-021-02993-x, PubMed: 34460008)
7.	川人伸次, 木下浩之, 高石和美, 曽我朋宏, 八木秀介, 北畑洋 : 細胞骨格ターンオーバー調節物質による細胞内経路制御機構の解明と麻酔薬作用, Precision Medicine, Vol.4, No.4, 32-35, 2021年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523951030917611264 (CiNii: 1523951030917611264)
8.	Kazumi Takaishi, Hiroyuki Kinoshita, Guo-Gang Feng, Toshiharu Azma, Shinji Kawahito and Hiroshi Kitahata : Cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle, Journal of Pharmacological Sciences, Vol.144, No.4, 197-203, 2020. (要約) The role of cytoskeleton dynamics in the oxidative stress toward human vasculature has been unclear. The current study examined whether the cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle. All experiments in the human omental arteries without endothelium or the cultured human coronary artery smooth muscle cells were performed in d-glucose (5.5 mmol/L). The exposure toward d-glucose (20 mmol/L) for 60 min reduced the relaxation or hyperpolarization to an ATP sensitive K channel (KATP) opener levcromakalim (10 to 3 × 10 mol/L and 3 × 10 mol/L, respectively). Cytochalasin B and a superoxide inhibitor Tiron, restored them similarly. Cytochalasin B reduced the NADPH oxidase activity, leading to a decrease in superoxide levels of the arteries treated with high d-glucose. Also, cytochalasin B impaired the F-actin constitution and the membrane translocation of an NADPH oxidase subunit p47phox in artery smooth muscle cells treated with high d-glucose. A clinical concentration of cytochalasin B prevented human vascular smooth muscle malfunction via the oxidative stress caused by high glucose. Regulation of the cytoskeleton may be essential to keep the normal vascular function in patients with hyperglycemia. (キーワード) Adult / Aged / Cells, Cultured / Cromakalim / Cytochalasin B / Cytoskeleton / Female / Glucose / Humans / Hyperglycemia / In Vitro Techniques / Male / Middle Aged / Muscle Relaxation / Muscle, Smooth, Vascular / Myocytes, Smooth Muscle / NADPH Oxidases / Oxidative Stress / Superoxides (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jphs.2020.08.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33070838 ● Search Scopus @ Elsevier (PMID): 33070838 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jphs.2020.08.004 (DOI: 10.1016/j.jphs.2020.08.004, PubMed: 33070838)
9.	Li Yang, Pu Tao-Fei, Li Xiao-Bo, Zhong Yi-Run, Yang Lin-An, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata and Jin-Ping Ao : GaN Schottky Barrier Diode-Based Wideband and Medium-Power Microwave Rectifier for Wireless Power Transmission, IEEE Transactions on Electron Devices, Vol.67, No.10, 4123-4129, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1109/TED.2020.3016619 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85092116357 (DOI: 10.1109/TED.2020.3016619, Elsevier: Scopus)
10.	Shinji Kawahito, Tomohiro Soga, Shusuke Yagi, Naoji Mita, Kazumi Takaishi, Hiroyuki Kinoshita, Tetsuya Kitagawa and Hiroshi Kitahata : Pathophysiology and complications during extracorporeal circulation, The Journal of Medical Investigation : JMI, Vol.67, No.3,4, 229-235, 2020. (徳島大学機関リポジトリ) ● Metadata: 115409 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.229 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148893 ● Search Scopus @ Elsevier (PMID): 33148893 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.229 (徳島大学機関リポジトリ: 115409, DOI: 10.2152/jmi.67.229, PubMed: 33148893)
11.	Kazumi Takaishi and Hiroshi Kitahata : Electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin., The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 230-232, 2019. (要約) Ferritin, an iron storage protein, plays an important role in iron homeostasis. The mechanism of reductive mobilization of iron from ferritin has not been clarified yet despite many studies. The aim of this study was to assess the mechanisms of the mobilization of iron from ferritin by NADPH P-450 reductase. Nucleotide-dependent flavoenzymes generated significant mobilization of iron from ferritin. The possibility of reductive mobilization of iron from ferritin by electrons released from flavin sites or heme site of two flavoenzymes was investigated to elucidate the mediator-independent mechanisms of such reductive mobilization. The mobilization by NADPH-P450 reductase in the presence of ferricyanide increased threefold, while in the presence of cytochrome C increased thirteen-fold. These results indicate that electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin. The mechanism of the mobilization of iron from ferritin is discussed. J. Med. Invest. 66 : 230-232, August, 2019. (徳島大学機関リポジトリ) ● Metadata: 114033 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.66.230 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656279 ● Search Scopus @ Elsevier (PMID): 31656279 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.230 (徳島大学機関リポジトリ: 114033, DOI: 10.2152/jmi.66.230, PubMed: 31656279)
12.	Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Shiho Satomi, Fumihiko Tada, Kinoshita Hiroyuki, Kazumi Takaishi and Hiroshi Kitahata : Continuous blood glucose monitoring during pediatric cardiopulmonary bypass., Clinical Pediatric Anesthesia, Vol.25, No.1, 3-7, 2019. (徳島大学機関リポジトリ) ● Metadata: 113628 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050302172852999552 (徳島大学機関リポジトリ: 113628, CiNii: 1050302172852999552)
13.	Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Nami Kakuta, Shiho Satomi, Hiroyuki Kinoshita, Kazumi Takaishi, Tetsuya Kitagawa and Hiroshi Kitahata : Accuracy and reliability of continuous blood glucose monitoring during pediatric cardiopulmonary bypass., Journal of Artificial Organs, Vol.22, No.4, 353-356, 2019. (要約) The purpose of this study was to assess the accuracy and reliability of a continuous blood glucose monitoring system (artificial endocrine pancreas; STG-55, Nikkiso, Tokyo, Japan) during pediatric cardiopulmonary bypass surgery. Twenty-five pediatric patients scheduled to undergo cardiovascular surgery with cardiopulmonary bypass (age 4 months to 11 years; body weight 5.6-59.7 kg) were enrolled. The glucose sensor line of the artificial endocrine pancreas was connected to the venous side of the cardiopulmonary bypass circuit and used for continuous blood glucose monitoring. We obtained 192 samples for blood gas assessment from the cardiopulmonary bypass circuit, and i-STAT (Abbott, East Windsor, NJ, USA) was used for conventional blood glucose assessment. The accuracies of continuous glucose measurements (STG-55) and conventional intermittent glucose measurements (i-STAT) during cardiopulmonary bypass were compared by means of Clarke error grid analysis. The results were divided into five zones, A, B, C, D, and E, and 78.6% of paired measurements were in zone A, while 21.4% were in zone B. We confirmed that the results of this continuous blood glucose monitoring system for cardiopulmonary bypass during pediatric cardiovascular surgery were highly reliable. An artificial endocrine pancreas may facilitate the safe use of intensive insulin therapy during pediatric cardiovascular surgery. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10047-019-01111-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31236730 ● Search Scopus @ Elsevier (PMID): 31236730 ● Search Scopus @ Elsevier (DOI): 10.1007/s10047-019-01111-9 (DOI: 10.1007/s10047-019-01111-9, PubMed: 31236730)
14.	Xiaobo Li, Taofei Pu, Taiki Hoshi, Tong Zhang, Xie Tian, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata, Liuan Li, Sachio Kobayashi, Motoo Ito, Xianjie Li and Jin-Ping Ao : GaN Schottky barrier diodes with nickel nitride anodes sputtered at different nitrogen partial pressure, Vacuum, Vol.162, 72-77, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.vacuum.2019.01.030 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85060431976 (DOI: 10.1016/j.vacuum.2019.01.030, Elsevier: Scopus)
15.	箕田直治, 川人伸次, 里見志帆, 笠井飛鳥, 曽我朋宏, 酒井陽子, 高石和美, 北畑洋, 堤保夫, 田中克哉 : 慢性炎症性脱髄性多発根ニューロパチー患者に対する肝切除術の麻酔経験, 麻酔, Vol.68, No.4, 409-412, 2019年. (キーワード) 慢性炎症性脱髄性多発根ニューロパチー(CIDP) / 全身麻酔 / 超音波ガイド下神経ブロック / 肝切除術 / chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) / general anesthesia / ultrasound-guided peripheral nerve block / hepatectomy (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520009407524776192 (CiNii: 1520009407524776192)
16.	箕田直治, 川人伸次, 張雄紀, 里見志帆, 植村勇太, 酒井陽子, 高石和美, 北畑洋, 堤保夫, 田中克哉 : 帝王切開後に産褥性心筋症を発症し心不全に陥った筋緊張性ジストロフィー妊婦の麻酔経験, 麻酔, Vol.68, No.2, 148-152, 2019年. (キーワード) 筋緊張性ジストロフィー / 帝王切開 / 産褥性心筋症 / myotonic dystrophy / cesarean section / peripartum cardiomyopathy (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520009408094420096 (CiNii: 1520009408094420096)
17.	山本剛士, 高石和美, 大塚良, 藤原茂樹, 江口覚, 北畑洋 : QTc延長患者における全身麻酔中のQTc変動, 日本歯科麻酔学会雑誌, Vol.47, No.2, 53-55, 2019年. (要約) <p> Long QT syndrome is characterized by a prolongation of the QT interval and a morphological change in the T wave on an electrocardiogram. Prolongation of the QT interval is associated with serious arrhythmia and may cause syncope and sudden death. A 13-year-old male with a prolonged corrected QT interval (QTc) on a preoperative electrocardiogram was scheduled to undergo the extractation of a supernumerary tooth under general anesthesia.</p><p> Although he had no remarkable past medical history, his QTc was prolonged to 514 ms on a 12-lead electrocardiogram. There was no history of syncope or sudden death in his family. The QTc at the time of his entrance into the operation room was 483 ms. During surgery, his QTc was continuously monitored in addition to the usual intraoperative monitoring. After the rapid introduction of anesthesia with remifentanil and propofol, the anesthesia was maintained with remifentanil and sevoflurane in oxygen and air. No significant change in the QTc was observed at the time of tracheal intubation accompanied by sympathetic stimulation. There was also no significant change in the QTc after the administration of atropine for bradycardia. However, when 2% lidocaine containing adrenaline was used for local anesthesia, the QTc gradually became prolonged reaching a maximum of 507 ms. In patients with a prolonged QT interval on a preoperative electrocardiogram, careful attention may be needed during the use of local anesthetics containing adrenaline. In addition, continuous monitoring of the QTc during surgery may be useful for the prevention of serious arrhythmias.</p> (キーワード) QT延長症候群 / QTc延長 / QTc変動 / アドレナリン含有リドカイン (出版サイトへのリンク) ● Publication site (DOI): 10.24569/jjdsa.47.2_53 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390564238083486464 ● Search Scopus @ Elsevier (DOI): 10.24569/jjdsa.47.2_53 (DOI: 10.24569/jjdsa.47.2_53, CiNii: 1390564238083486464)
18.	Kazumi Takaishi, Shinji Kawahito, Shigeki Fujiwara Joseph Luke and Hiroshi Kitahata : Nasotracheal intubation through pharyngeal flap after pharyngeal flap construction., Journal of Clinical Anesthesia, Vol.44, 121-122, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jclinane.2017.11.026 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29197265 ● Search Scopus @ Elsevier (PMID): 29197265 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jclinane.2017.11.026 (DOI: 10.1016/j.jclinane.2017.11.026, PubMed: 29197265)
19.	藤原茂樹, 大塚良, 尾上真奈美, 江口覚, 高石和美, 北畑洋 : 閉塞型睡眠時無呼吸症候群を伴った成人スティル病患者の嚢胞摘出術における静脈内鎮静法下患者管理の経験, 臨床麻酔, Vol.42, No.2, 220-222, 2018年.
20.	藤原茂樹, 大塚良, 尾上真奈美, 江口覚, 高石和美, 北畑洋 : Stevens-Johnson症候群の既往がある難治性てんかん患者の全身麻酔経験, 臨床麻酔, Vol.41, No.10, 1424-1426, 2017年.
21.	Shinji Kawahito, Tomohiro Soga, Naoji Mita, Shiho Satomi, Hiroyuk Kinoshita, Tomoko Arase, Akira Kondo, Hitoshi Miki, Kazumi Takaishi and Hiroshi Kitahata : Successful treatment of mixed (mainly cancer) pain by tramadol preparations, The Journal of Medical Investigation : JMI, Vol.64, No.3,4, 311-312, 2017. (要約) The patient, a 70-year-old Japanese woman diagnosed with parotid gland cancer, underwent wide excision and reconstruction (facial nerve ablation, nerve transposition). At 1 month after the surgery, she was brought to our hospital's pain medicine department because her postoperative pain and cancer-related pain were poorly controlled. She had already been prescribed a tramadol (37.5 mg)/acetaminophen (325 mg) combination tablet (5 tablets/day). However, in addition to the continuous pain in her face and lower limbs, she was troubled by a trigeminal neuralgia-like prominence ache. Because this pain could not be controlled by an increase to eight combination tablets per day, we switched her medication to a tramadol capsule. At 11 months post-surgery, we then switched her medication to an orally disintegrating tramadol tablet to improve medication adherence of the drug. From 14 months post-surgery, the patient also used a sustained-release tramadol preparation, and she was then able to sleep well. Her current regimen is an orally disintegrating sustained-release tablet combination (total 300 mg tramadol) per day, and she achieved sufficient pain relief. Because tramadol is not classified as a medical narcotic drug, it widely available and was shown here to be extremely useful for the treatment of our patient's mixed (mainly cancer) pain. J. Med. Invest. 64: 311-312, August, 2017. (徳島大学機関リポジトリ) ● Metadata: 111141 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.64.311 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28955004 ● Summary page in Scopus @ Elsevier: 2-s2.0-85030217544 (徳島大学機関リポジトリ: 111141, DOI: 10.2152/jmi.64.311, PubMed: 28955004, Elsevier: Scopus)
22.	Naoji Mita, Shinji Kawahito, Tomohiro Soga, Kazumi Takaishi, Hiroshi Kitahata, Munehide Matsuhisa, Mitsuo Shimada, Kinoshita Hiroyuki, Yasuo Tsutsumi and Katsuya Tanaka : Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury, Journal of Artificial Organs, Vol.20, No.1, 76-83, 2017. (要約) The aim of the present study was to evaluate the usefulness of a closed-loop system (STG-55; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose, for preventing postoperative acute kidney injury (AKI) in patients undergoing hepatectomy. Thirty-eight patients were enrolled in this study. Glucose concentrations were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n = 19) or the programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n = 19). After the induction of anesthesia, a 20-G intravenous catheter was inserted into the peripheral forearm vein of patients in the programmed insulin group and connected to an artificial endocrine pancreas (STG-55). The target range for glucose concentrations was set to 100-150 mg/dL. The mean serum creatinine concentrations of preoperative, postoperative 24 and 48 h were 0.72, 0.78, and 0.79 mg/dL in the programmed insulin group, and 0.81, 0.95, and 1.03 mg/dL in the manual insulin group, respectively. Elevations in serum creatinine concentrations postoperative 48 h were significantly suppressed in the programmed insulin group. The STG-55 closed-loop system was effective for maintaining strict blood glucose control during hepatectomy with minimal variability in blood glucose concentrations and for suppressing elevations in serum creatinine concentrations. Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative AKI. (キーワード) Acute Kidney Injury / Aged / Aged, 80 and over / Blood Glucose / Creatinine / Female / Hepatectomy / Humans / Insulin / Insulin Infusion Systems / Japan / Male / Middle Aged / Pancreas, Artificial / Postoperative Complications / Treatment Outcome (徳島大学機関リポジトリ) ● Metadata: 110117 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10047-016-0925-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27557726 ● Search Scopus @ Elsevier (PMID): 27557726 ● Search Scopus @ Elsevier (DOI): 10.1007/s10047-016-0925-6 (徳島大学機関リポジトリ: 110117, DOI: 10.1007/s10047-016-0925-6, PubMed: 27557726)
23.	Shigeki Fujiwara Joseph Luke, Michiko Yasuda, Tomoko Kinugawa, Shoko Itakura, Kazu-ichi Yoshida, Hiroshi Kitahata and Takeshi Yokoyama : Contractile response of lipopolysaccharide-treated rat thoracic aortas ot adrenaline or noradrenaline with or without local anaesthetic agents., Biomedical Research (India), Vol.28, No.9, 3826-3831, 2017. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85019708659 (Elsevier: Scopus)
24.	Naoji Mita, Shinji Kawahito, Tomohiro Soga, Tosiko Katayama, Narutomo Wakamatsu, Tomiya Kawahara, Nami Kakuta, Eisuke Hamaguchi, Yasuo Tsutsumi, Katsuya Tanaka, Kazumi Takaishi and Hiroshi Kitahata : Anesthetic management of a patient with unruptured sinus of valsalva aneurysm with right ventricular outflow tract obstruction., Circulation Control, Vol.37, No.3, 195-198, 2016. (出版サイトへのリンク) ● Publication site (DOI): 10.11312/ccm.37.195 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11312/ccm.37.195 (DOI: 10.11312/ccm.37.195)
25.	Otsuka Ryo, Nagakatsu Harada, Aoki Shouhei, Shirai Kanna, Kazuchika Nishitsuji, Nozaki Ayane, Hatakeyama Adzumi, Masayuki Shono, Noriko Mizusawa, Katsuhiko Yoshimoto, Yutaka Nakaya, Hiroshi Kitahata and Hiroshi Sakaue : C-terminal region of GADD34 regulates eIF2alpha dephosphorylation and cell proliferation in CHO-K1 cells., Cell Stress & Chaperones, Vol.21, No.1, 29-40, 2016. (要約) GADD34 is a member of a growth arrest and DNA damage (GADD)-inducible gene family. Here, we established a novel Chinese hamster ovary (CHO)-K1-derived cell line, CHO-K1-G34M, which carries a nonsense mutation (termed the Q525X mutation) in the GADD34 gene. The Q525X mutant protein lacks the C-terminal 66 amino acids required for GADD34 to bind to and activate protein phosphatase 1 (PP1). We investigated the effects of GADD34 with or without the Q525X mutation on the phosphorylation status of PP1 target proteins, including the subunit of eukaryotic initiation factor 2 (eIF2) and glycogen synthase kinase 3 (GSK3). CHO-K1-G34M cells had higher levels of eIF2 phosphorylation compared to the control CHO-K1-normal cells both in the presence and absence of endoplasmic reticulum stress. Overexpression of the wild-type GADD34 protein in CHO-K1-normal cells largely reduced eIF2 phosphorylation, while overexpression of the Q525X mutant did not produce similar reductions. Meanwhile, neither wild type nor Q525X mutation of GADD34 affected the GSK3 phosphorylation status. GADD34 also did not affect the canonical Wnt signaling pathway downstream of GSK3. Cell proliferation rates were higher, while expression levels of the cyclin-dependent kinase inhibitor p21 were lower in CHO-K1-G34M cells compared to the CHO-K1-normal cells. The GADD34 Q525X mutant had a reduced ability to inhibit cell proliferation and enhance p21 expression of the CHO-K1-normal cells compared to the wild-type GADD34 protein. These results suggest that the GADD34 protein C-terminal plays important roles in regulating not only eIF2 dephosphorylation but also cell proliferation in CHO-K1 cells. (徳島大学機関リポジトリ) ● Metadata: 110106 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12192-015-0633-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26318739 ● Summary page in Scopus @ Elsevier: 2-s2.0-84951905379 (徳島大学機関リポジトリ: 110106, DOI: 10.1007/s12192-015-0633-9, PubMed: 26318739, Elsevier: Scopus)
26.	Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Toshiko Katayama, Kohei Fukuta, Hiroaki Kawano, Fumihiko Tada, Yasuo M. Tsutsumi, Katsuya Tanaka, Kazumi Takaishi and Hiroshi Kitahata : Role of transesophageal echocardiography during biventricular pacemaker implantation in children, Clinical Pediatric Anesthesia, Vol.21, 182-185, 2015.
27.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 北畑洋 : 特発性間質性肺炎を合併した患者に対する口腔外科長時間手術の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.43, No.2, 265-267, 2015年.
28.	大塚良, 青山智祐, 江口覚, 高石和美, 富岡重正, 北畑洋 : 静脈穿刺により発症した血管迷走神経性失神時に心拍変動解析を行った1例, 日本歯科麻酔学会雑誌, Vol.43, No.2, 268-270, 2015年.
29.	Noriko Kambe, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tosiko Katayama, Yoko Sakai, Tomohiro Soga, Hiroaki Kawano, Munehide Matsuhisa, Mitsuo Shimada, Tetsuya Kitagawa and Hiroshi Kitahata : Impact of newly developed, next-generation artificial endocrine pancreas, The Journal of Medical Investigation : JMI, Vol.62, No.1-2, 41-44, 2015. (要約) Recent studies have shown that strict perioperative blood glucose management may reduce mortality and morbidity in critically ill adult patients. The purpose of this study was to assess the accuracy and efficacy of the intraoperative application of a newly developed, next-generation artificial endocrine pancreas (STG-55, Nikkiso Co., Ltd., Tokyo, Japan). Twenty patients scheduled to undergo surgery were enrolled in this study. The STG-55 is designed to be more user-friendly than its conventional counterpart (STG-22) while maintaining the latter's fundamental functions, such as a closed-loop system using algorithms for insulin and glucose infusion. After anesthetic induction, a 20G intravenous catheter was inserted into a peripheral forearm vein and connected to a continuous blood glucose monitor. The resultant 105 scores for paired blood glucose values were compared by Bland-Altman analysis. Stable blood glucose values were maintained automatically, and there were no complications related to use of the STG-55. A close correlation (r=0.96) was observed between continuous glucose measurements using the STG-55 and conventional intermittent glucose measurements. The difficulty of manipulation using this system was decreased by improved preparation procedures. The glycemic control system using the STG-55 could provide an alternative way to achieve effective and safe perioperative glycemic control. (キーワード) artificial endocrine pancreas (徳島大学機関リポジトリ) ● Metadata: 111244 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.62.41 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25817282 ● Summary page in Scopus @ Elsevier: 2-s2.0-84925857956 (徳島大学機関リポジトリ: 111244, DOI: 10.2152/jmi.62.41, PubMed: 25817282, Elsevier: Scopus)
30.	Yasuo Tsutsumi, Rie Tsutsumi, Yousuke T. Horikawa, Yoko Sakai, Eisuke Hamaguchi, Hiroshi Kitahata, Asuka Kasai, Noriko Kambe and Katsuya Tanaka : Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, Vol.28, No.5, 733-739, 2014. (要約) Pharmacological preconditioning, including that with geranylgeranylacetone (GGA) and volatile anesthetics, has been shown to confer cardiac protection from ischemia/reperfusion injury although the mechanisms for this protection are poorly understood. Caveolins, integral membrane proteins that act as scaffolding proteins in caveolar membranes, localize molecules involved in cardiac protection. We have tested the hypothesis that caveolin-3 (Cav-3), the predominant isoform in cardiac myocytes, is essential for the synergistic effect observed between GGA and volatile anesthetics. Mice were randomly assigned to receive GGA, isoflurane [0.5 and 1.0 minimum alveolar concentration (MAC)], or GGA + isoflurane (0.5 MAC). An in vivo mouse model of ischemia/reperfusion injury was tested in wild-type and Cav-3 knockout mice, and the infarct size was determined. Biochemical assays were also performed in excised hearts. Geranylgeranylacetone and therapeutic isoflurane (1.0 MAC) independently reduced infarct size (31.6 ± 6.1 and 28.0 ± 5.0 % of the area at risk, respectively; n = 10) as compared to the controls (45.8 ± 9.4 %; n = 10). The combination GGA + sub-therapeutic isoflurane (0.5 MAC) further decreased the infarct size to 19.3 ± 5.1 % (n = 10). Preconditioning [GGA, isoflurane (1.0 MAC), and GGA + isoflurane] increased the amount of Cav-3 protein in the discontinuous sucrose-gradient buoyant fractions. Additionally, cardiac protection was not observed in Cav-3 knockout mice following the administration of GGA, isoflurane, and GGA + isoflurane. Combined administration of GGA + isoflurane had a synergistic effect, enhancing the protection against myocardial infarction to a greater extent than either drug alone. This beneficial effect is mediated by Cav-3 expression. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-014-1816-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24633659 ● Search Scopus @ Elsevier (PMID): 24633659 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-014-1816-8 (DOI: 10.1007/s00540-014-1816-8, PubMed: 24633659)
31.	Kazumi Takaishi, Shinji Kawahito, Shigemasa Tomioka, Satoru Eguchi and Hiroshi Kitahata : Cuffed oropharyngeal airway for difficult airway management., Anesthesia Progress, Vol.61, No.3, 107-110, 2014. (要約) Abstract Difficulties with airway management are often caused by anatomic abnormalities due to previous oral surgery. We performed general anesthesia for a patient who had undergone several operations such as hemisection of the mandible and reconstructive surgery with a deltopectoralis flap, resulting in severe maxillofacial deformation. This made it impossible to ventilate with a face mask and to intubate in the normal way. An attempt at oral awake intubation using fiberoptic bronchoscopy was unsuccessful because of severe anatomical abnormality of the neck. We therefore decided to perform retrograde intubation and selected the cuffed oropharyngeal airway (COPA) for airway management. We inserted the COPA, not through the patient's mouth but through the abnormal oropharyngeal space. Retrograde nasal intubation was accomplished with controlled ventilation through the COPA, which proved to be very useful for this difficult airway management during tracheal intubation even though the method was unusual. (出版サイトへのリンク) ● Publication site (DOI): 10.2344/0003-3006-61.3.107 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25191984 ● Search Scopus @ Elsevier (PMID): 25191984 ● Search Scopus @ Elsevier (DOI): 10.2344/0003-3006-61.3.107 (DOI: 10.2344/0003-3006-61.3.107, PubMed: 25191984)
32.	Yoko Sakai, Shinji Kawahito, Kazumi Takaishi, Naoji Mita, Hiroyuki Kinoshita, Noboru Hatakeyama, Toshiharu Azma, Yutaka Nakaya and Hiroshi Kitahata : Propofol-induced relaxation of rat aorta is altered by aging., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 278-284, 2014. (要約) Propofol causes vasodilation via endothelium-dependent and -independent mechanisms. Because endothelial function is impaired with aging, the effects of propofol on endothelium-dependent vasodilation might be altered by aging. The aim of this study was thus to determine the effects of aging on vascular responses to propofol. Young (4-6 weeks old) or adult (16-25 weeks old) rats were anesthetized with sevoflurane. The thoracic aorta was dissected and cut into pieces 3-4 mm in length. In some rings, the endothelium was deliberately removed. The ring segment of the aorta was mounted for isometric force recording at a resting tension of 0.5-1.0 g in a 2 ml organ bath, containing Krebs-Ringer bicarbonate buffer. Arteries were precontracted with phenylephrine, and the function of endothelium was confirmed with acetylcholine. Then, we studied the concentration-dependent effects of propofol in endothelium-intact (control group) and -denuded aortic rings (denuded group), as well as those treated with N()-nitro-L-arginine methylester (L-NAME group). Relaxation due to propofol was observed in the control groups of both young and adult rats in a concentration-dependent manner, but the magnitude of relaxation was significantly greater in young rats. In addition, in young rats, relaxation due to propofol was significantly and equally reduced in both L-NAME and denuded groups at all propofol concentrations that we studied (10(-6)-10(-3) M). In adult rats, relaxation due to propofol was quite similar between control and L-NAME groups at all propofol concentrations, whereas it was significantly reduced in the denuded group. These results suggest that endothelium-derived nitric oxide plays an important role in propofol-induced vasodilation in young rats, but not in adult rats. J. Med. Invest. 61: 278-284, August, 2014. (徳島大学機関リポジトリ) ● Metadata: 109571 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.61.278 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264045 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907560765 (徳島大学機関リポジトリ: 109571, DOI: 10.2152/jmi.61.278, PubMed: 25264045, Elsevier: Scopus)
33.	Kayo Hirose, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tomiya Kawahara, Tomohiro Soga, Toshiko Katayama, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mitsuo Shimada, Munehide Matsuhisa and Hiroshi Kitahata : Usefulness of artificial endocrine pancreas during resection of insulinoma., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 421-425, 2014. (要約) A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state. The target concentration of blood glucose was set at 80-120 mg/dl during surgery. Until removal of the tumor, the blood glucose level was kept at around 80-100 mg/dl. After removal of the tumor, the blood glucose level gradually increased, but it was kept in the normal range by the artificial endocrine pancreas. The artificial endocrine pancreas was useful to monitor and maintain blood glucose levels during and after the removal of insulinoma, without any hyper- or hypoglycemia. J. Med. Invest. 61: 421-425, August, 2014. (徳島大学機関リポジトリ) ● Metadata: 109597 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.61.421 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264066 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907483198 (徳島大学機関リポジトリ: 109597, DOI: 10.2152/jmi.61.421, PubMed: 25264066, Elsevier: Scopus)
34.	Nami Kakuta, Shinji Kawahito, Tomohiro Soga, Naoji Mita, Kouhei Fukuta, Narutomo Wakamatsu, Yoko Sakai, Tosiko Katayama, Fumihiko Tada, Kazumi Takaishi and Hiroshi Kitahata : Role of an intraoperative single-plane transesophageal echocardiography probe for infants with congenital heart disease, Clinical Pediatric Anesthesia, Vol.20, No.1, 231-235, 2014.
35.	桃田幸弘, 高野栄之, 可児耕一, 高石和美, 中川弘, 富岡重正, 郡由紀子, 橋本俊顕, 北畑洋, 東雅之 : いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について, 四国歯学会雑誌, Vol.26, No.2, 35-40, 2014年.
36.	Kazumi Takaishi, Shinji Kawahito, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata and Hiroshi Kitahata : Increase in prominence of electrocardiographic J waves after a single dose of propofol in a patient with early ventricular repolarisation., Anaesthesia, Vol.69, No.2, 170-175, 2014. (要約) J waves appear on an electrocardiogram as an elevation of the J point in the terminal portion of the QRS complex. J waves are often benign, but may be associated with malignant ventricular arrhythmias. In some cases, such problems appear to have been precipitated by propofol infusions. We observed a sudden increase in J waves and profound hypotension following a single intravenous dose of propofol in an 84-year-old woman with early repolarisation in the inferior ventricular wall. When early repolarisation (as shown by electrocardiographic J waves) is observed in the inferior ventricular wall pre-operatively, patients should be carefully monitored. Myocardial ischaemia and the use of drugs that might worsen J waves should be avoided. (キーワード) Aged, 80 and over / Anesthetics, Intravenous / Electrocardiography / Female / Humans / Hypotension / Intraoperative Complications / Monitoring, Intraoperative / Propofol / Ventricular Fibrillation (出版サイトへのリンク) ● Publication site (DOI): 10.1111/anae.12448 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24116860 ● Summary page in Scopus @ Elsevier: 2-s2.0-84892799834 (DOI: 10.1111/anae.12448, PubMed: 24116860, Elsevier: Scopus)
37.	Shinji Kawahito, Seiichi Higuchi, Naoji Mita, Tetsuya Kitagawa and Hiroshi Kitahata : Novel blood sampling method of an artificial endocrine pancreas via the cardiopulmonary bypass circuit., Journal of Artificial Organs, Vol.16, No.4, 508-509, 2013. (要約) We tried to perform continuous blood glucose monitoring during cardiovascular surgery involving cardiopulmonary bypass using an artificial endocrine pancreas (STG-22 or -55; Nikkiso, Tokyo, Japan); however, we often encountered problems during these procedures because insufficient blood was obtained for monitoring. Thus, we started performing the blood sampling via the venous side of the cardiopulmonary bypass circuit. As a result, continuous blood glucose monitoring using an artificial endocrine pancreas was proven to be stable and reliable during cardiovascular surgery involving cardiopulmonary bypass. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10047-013-0725-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23989924 ● Search Scopus @ Elsevier (PMID): 23989924 ● Search Scopus @ Elsevier (DOI): 10.1007/s10047-013-0725-1 (DOI: 10.1007/s10047-013-0725-1, PubMed: 23989924)
38.	Nami Kakuta, Shinji Kawahito, Naoji Mita, Noriko Kambe, Asuka Kasai, Narutomo Wakamatsu, Tosiko Katayama, Tomohiro Soga, Fumihiko Tada, Takashi Kitaichi, Tetsuya Kitagawa and Hiroshi Kitahata : Usefulness of central venous oxygen saturation monitoring during bidirectional Glenn shunt., The Journal of Medical Investigation : JMI, Vol.60, No.3, 4, 272-275, 2013. (要約) A PediaSat™ oximetry catheter (PediaSat: Edwards Lifesciences Co., Ltd., Irvine, CA, U. S. A.), which facilitates continuous measurement of central venous oxygen saturation (ScvO2), may be useful for surgery for pediatric congenital heart disease. We used PediaSat during a bidirectional Glenn shunt. The patient was a 13-month-old boy. Under a diagnosis of left single ventricle (pulmonary atresia, right ventricular hypoplasia, atrial septal defect) and residual left aortic arch/left superior vena cava, a modified right Blalock-Taussig shunt was performed. Cyanosis deteriorated, so a bidirectional Glenn shunt was scheduled. After anesthesia induction, a 4.5 Fr double-lumen (8 cm) PediaSat was inserted through the right internal jugular vein for continuous ScvO2 monitoring. Furthermore, the probe of a near-infrared, mixed blood oxygen saturation-measuring monitor was attached to the forehead for continuous monitoring of the regional brain tissue mixed blood oxygen saturation (rSO2) (INVOS™ 5100C, Covidien; Boulder, CO, U. S. A.). Blockage of the right pulmonary artery and right superior vena cava decreased the oxygen saturation, ScvO2, and rSO2, but increased the central venous pressure. Although changes in ScvO2 were parallel to those in rSO2, the former showed more marked changes. A combination of ScvO2 and rSO2 for monitoring during Glenn shunt may be safer. (キーワード) Blood Gas Monitoring, Transcutaneous / Catheterization, Central Venous / Fontan Procedure / Heart Defects, Congenital / Heart Ventricles / Humans / Infant / Male / Monitoring, Intraoperative / Oximetry (徳島大学機関リポジトリ) ● Metadata: 106368 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.60.272 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190047 ● Summary page in Scopus @ Elsevier: 2-s2.0-84887009442 (徳島大学機関リポジトリ: 106368, DOI: 10.2152/jmi.60.272, PubMed: 24190047, Elsevier: Scopus)
39.	Kazumi Takaishi, Hiroshi Kitahata and Shinji Kawahito : Local anesthetics inhibit nitric oxide production and l-arginine uptake in cultured bovine aortic endothelial cells., European Journal of Pharmacology, Vol.704, No.1-3, 58-63, 2013. (要約) Previous studies have shown that local anesthetics have various effects on nitric oxide (NO) production, but the mechanisms remain unclear. The purpose of this study was to evaluate the effects of local anesthetics on NO production and 2-amino-5-guanidinopentanoic acid (l-arginine) uptake in one cell line. Cultured bovine aortic endothelial cells (BAEC) were stimulated with bradykinin and/or acetylcholine to activate endothelial NO synthase (NOS). BAEC were also incubated with interleukin-1β and lipopolysaccharide to stimulate inducible NOS. NO production was measured with the rapid spectrophotometric method, and l-arginine uptake was measured with high performance liquid chromatography. To assess the effects of local anesthetics, NO production and l-arginine uptake were measured in the presence or absence of procaine or lidocaine. NO was produced in BAEC stimulated with bradykinin and acetylcholine or interleukin-1β and lipopolysaccharide, but NO production was not affected by the addition of superoxide dismutase. In the cells stimulated with bradykinin and acetylcholine, 10 μM each of procaine and lidocaine significantly inhibited NO production by 35% and 20%, respectively. In the cells incubated with interleukin-1ß and lipopolysaccharide, the same quantities of procaine and lidocaine significantly inhibited NO production by 15% and 10%, respectively. Both procaine and lidocaine significantly suppressed l-arginine uptake in BAEC stimulated with either bradykinin/acetylcholine or interleukin-1β/lipopolysaccharide. It is suggested that inhibitory effects of procaine and lidocaine on NO production are partially due to suppression of l-arginine uptake. (キーワード) Anesthetics, Local / Animals / Aorta / Arginine / Cattle / Cells, Cultured / Endothelial Cells / Lidocaine / Nitric Oxide / Nitric Oxide Synthase Type II / Nitric Oxide Synthase Type III / Procaine (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ejphar.2013.02.014 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23461848 ● Summary page in Scopus @ Elsevier: 2-s2.0-84874940599 (DOI: 10.1016/j.ejphar.2013.02.014, PubMed: 23461848, Elsevier: Scopus)
40.	Tomohiro Soga, Shinji Kawahito, Nami Kakuta, Tosiko Katayama, Narutomo Wakamatsu, Kazumi Takaishi, Kunihisa Yamaguchi, Hirofumi Izaki, Hiro-omi Kanayama, Hiroshi Kitahata and Shuzo Oshita : Recent less-invasive circulatory monitoring during renal transplantation., The Journal of Medical Investigation : JMI, Vol.60, No.1, 2, 159-163, 2013. (要約) For anesthetic management during renal transplantation, it is necessary to maintain the blood flow and function of the transplanted kidney by performing massive fluid management and stabilizing blood pressure. We report anesthetic management for renal transplantation with a less-invasive circulatory monitoring system (Edwards Life Sciences Co., Ltd., Irvine, California, U.S.A.). In November 2010, renal transplantation was started in our hospital, and performed in 6 patients. In the first patient, fluid/circulatory management was conducted by connecting a standard arterial line and a standard central venous (CV) line. In the second patient, a FloTrac(TM) system and a standard CV line were used. In the third patient, a standard arterial line and a PreSep(TM) CV Oximetry Catheter were used. In the fourth and fifth patients, a FloTrac(TM) and a PreSep(TM) were used. In the latest patient, FloTrac(TM) and PreSep(TM) were connected to an EV1000(TM) Clinical Platform for fluid/circulatory management. The establishment of high-visibility monitors was useful for evaluating the condition and confirming the effects. As there are marked changes in hemodynamics, the CV pressure, which has been used as a parameter of fluid management, is not reliable in renal failure patients with a high incidence of cardiovascular complications. Advances in noninvasive circulatory monitoring with dynamic indices may improve the safety of anesthetic management during renal transplantation. (キーワード) Adolescent / Adult / 麻酔 (anesthesia) / Cardiac Output / Central Venous Pressure / Humans / Kidney Transplantation / Middle Aged / Monitoring, Physiologic / Oxygen (徳島大学機関リポジトリ) ● Metadata: 106058 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.60.159 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614926 ● CiNii @ 国立情報学研究所 (CRID): 1390282679221800704 ● Summary page in Scopus @ Elsevier: 2-s2.0-84876046292 (徳島大学機関リポジトリ: 106058, DOI: 10.2152/jmi.60.159, PubMed: 23614926, CiNii: 1390282679221800704, Elsevier: Scopus)
41.	Tsuyoshi Okada, Shinji Kawahito, Naoji Mita, Munehide Matsuhisa, Hiroshi Kitahata, Mitsuo Shimada and Shuzo Oshita : Usefulness of continuous blood glucose monitoring and control for patients undergoing liver transplantation., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 205-212, 2013. (要約) The STG-22 closed-loop system is effective for maintaining strict blood glucose control during liver transplantation with minimal variability in blood glucose concentration. (徳島大学機関リポジトリ) ● Metadata: 106358 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.60.205 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190037 ● Summary page in Scopus @ Elsevier: 2-s2.0-84887004443 (徳島大学機関リポジトリ: 106358, DOI: 10.2152/jmi.60.205, PubMed: 24190037, Elsevier: Scopus)
42.	立石智子, 富岡重正, 古北まゆ子, 高瀬奈緒, 大西杏奈, 高石和美, 江口覚, 北畑洋 : 尋常性天疱瘡患者における頬粘膜腫瘍切除術の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.40, No.5, 610-611, 2012年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571417126119421056 ● Summary page in Scopus @ Elsevier: 2-s2.0-84868528160 (CiNii: 1571417126119421056, Elsevier: Scopus)
43.	Shinji Kawahito, Takashi Kawano, Hiroshi Kitahata, Jun Oto, Akira Takahashi, Kazumi Takaishi, Nagakatsu Harada, Tadahiko Nakagawa, Hiroyuki Kinoshita, Toshiharu Azma, Yutaka Nakaya and Shuzo Oshita : Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels., Anesthesia & Analgesia, Vol.113, No.6, 1374-1380, 2011. (要約) We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch-clamp method, we investigated the effects of clonidine on the following: (1) native vascular K(ATP) channels; (2) recombinant K(ATP) channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits; (3) SUR-deficient channels derived from a truncated isoform of the Kir6.2 subunit (Kir6.2ΔC36 channels); and (4) mutant Kir6.2ΔC36 channels with diminished sensitivity to ATP (Kir6.2ΔC36-K185Q channels). Clonidine (≥3 × 10(-8) M) inhibited native K(ATP) channel activity in cell-attached configurations with a half-maximal inhibitory concentration value of 1.21 × 10(-6) M and in inside-out configurations with a half-maximal inhibitory concentration value of 0.89 × 10(-6) M. With similar potency, clonidine (10(-6) or 10(-3) M) also inhibited the activities of various recombinant SUR/Kir6.0 K(ATP) channels, the Kir6.2ΔC36 channel, and the Kir6.2ΔC36-K185Q channel. Clinically relevant concentrations of clonidine inhibit K(ATP) channel activity in vascular smooth muscle cells. This inhibition seems to be the result of its effect on the Kir6.0 subunit and not on the SUR subunit. (キーワード) Animals / COS Cells / Cell Line / Cercopithecus aethiops / Clonidine / Humans / KATP Channels / Muscle, Smooth, Vascular / Potassium Channel Blockers / Potassium Channels, Inwardly Rectifying / Rats (出版サイトへのリンク) ● Publication site (DOI): 10.1213/ANE.0b013e3182321142 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22003223 ● Search Scopus @ Elsevier (PMID): 22003223 ● Search Scopus @ Elsevier (DOI): 10.1213/ANE.0b013e3182321142 (DOI: 10.1213/ANE.0b013e3182321142, PubMed: 22003223)
44.	Hiroaki Kawano, E Hamaguchi, Shinji Kawahito, Yasuo Tsutsumi, Katsuya Tanaka, Hiroshi Kitahata and Shuzo Oshita : Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies., Anaesthesia, Vol.66, No.6, 515-518, 2011. (要約) Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including psychiatric symptoms, hypoventilation, seizures and derangement of autonomic nervous system function. Although recovery can sometimes occur spontaneously, early tumour resection with immunotherapy facilitates earlier recovery. Herein, we describe anaesthetic management of a 20-year-old woman who developed general convulsions and decreased level of consciousness, whom we suspected of having paraneoplastic limbic encephalitis and was scheduled for left ovarian tumour resection. Anaesthetic management was successful with no complications but the case acts as focus of discussion for the potential interaction of N-methyl-D-aspartate receptors and anaesthetic sensitivity. (キーワード) Anesthesia, General / Autoantibodies / Female / Humans / Limbic Encephalitis / Ovarian Neoplasms / Receptors, N-Methyl-D-Aspartate / Seizures / Teratoma / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1365-2044.2011.06707.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21457154 ● Search Scopus @ Elsevier (PMID): 21457154 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-2044.2011.06707.x (DOI: 10.1111/j.1365-2044.2011.06707.x, PubMed: 21457154)
45.	川人伸次, 北畑洋, 多田文彦, 中村智芳, 岡田剛, 東島祥代, 大下修造 : 小児感染性心内膜炎の周術期管理における心エコーの役割, 小児歯科学雑誌, Vol.16, No.1, 133-137, 2010年.
46.	高石和美, 富岡重正, 江口覚, 中井恵, 岩田英道, 榎本奈実, 髙丸菜都美, 北畑洋 : 小児患者の精神鎮静法に関する過去10年間の検討, 日本歯科麻酔学会雑誌, Vol.38, No.2, 176-179, 2010年. (キーワード) SEDATION / 子ども (children) / INTRAVENOUS / INHALATION / PREMEDICATION (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571980075955865728 (CiNii: 1571980075955865728)
47.	川人伸次, 井関明生, 北畑洋, 神原保, 北川哲也, 大下修造 : バージャー病に対する自己末梢血単核球細胞移植による血管新生治療, 日本臨床麻酔学会誌, Vol.29, No.7, 855-859, 2009年. (キーワード) Buerger's disease / Mononuclear cell implantation / Angiogenesis (出版サイトへのリンク) ● Publication site (DOI): 10.2199/jjsca.29.855 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679735888640 ● Search Scopus @ Elsevier (DOI): 10.2199/jjsca.29.855 (DOI: 10.2199/jjsca.29.855, CiNii: 1390282679735888640)
48.	中村智芳, 川人伸次, 河野裕明, 岡田剛, 北畑洋, 大下修造 : WPW症候群を合併したエプスタイン奇形の麻酔管理, 麻酔, Vol.58, No.4, 438, 2009年. (要約) Ebstein's anomaly is a rare congenital malformation of the tricuspid valve, often associated with Wolff-Parkinson-White (WPW) syndrome. We report the perioperative management of 3 patients (a 34-year-old man, a 5-month-old boy and a 5-year-old girl) with Ebstein's anomaly associated with WPW syndrome. Anesthetic managements for valvuloplasty of the tricuspid valve and ablation of accessory pathway in 3 patients were successfully accomplished with a combination of fentanyl, sevoflurane, and midazolam. The management of Ebstein's anomaly is based on its severity. The major concerns with anesthesia for children with Ebstein's anomaly include decreased cardiac output, right-to-left atrial level shunting with cyanosis, and the propensity for atrial tachyarrhythmias. We conclude that perioperative management of arrhythmia and evaluation of residual tricuspid regurgitation using transesophageal echocardiography are essential. (キーワード) エプスタイン奇形 / WPW症候群 / 発作性上室性頻拍 / 三尖弁逆流 / 先天性心疾患 / Ebstein's anomaly / WPW syndrome / paroxysmal supraventricular tachycardia / tricuspid regurgitation / congenital heart disease (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19364004 ● CiNii @ 国立情報学研究所 (CRID): 1520290882485976832 ● Summary page in Scopus @ Elsevier: 2-s2.0-64849097010 (PubMed: 19364004, CiNii: 1520290882485976832, Elsevier: Scopus)
49.	川人伸次, 中村智芳, 神邊紀子, 北畑洋, 島田光生, 西村匡司, 大下修造 : ② 意外に難しいスライディング・スケール法による血糖管理, --- 人工膵臓を用いた外科手術周術期血糖管理法 ---, 胆と膵, Vol.29, No.11, 1021-1028, 2008年.
50.	川人伸次, 北畑洋, 多田文彦, 中村智芳, 神邊紀子, 大下修造 : 小児先天性心疾患の最終診断のための経食道心エコー, 日本小児麻酔学会誌, Vol.14, No.1, 110-113, 2008年.
51.	Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Takehito Tomino and Shuzo Oshita : Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone., Anesthesia & Analgesia, Vol.107, No.3, 755-761, 2008. (要約) We investigated in rabbits whether sevoflurane enhances late cardioprotection induced by geranylgeranylacetone (GGA), a gastric antiulcer drug. S(+)-ketamine and xylazine-anesthetized rabbits were assigned to one of seven experimental groups: a control (vehicle only) group, a GGA group, a sevoflurane group, a GGA+sevoflurane group, a sodium 5-hydroxydecanoate (5HD) group, a GGA + 5HD group, and a heat stress group. All rabbits were subjected to 30 min of coronary artery occlusion followed by 3 h of reperfusion. Rabbits were pretreated with IV vehicle, GGA (10 mg/kg), or heat stress (42 degrees C for 15 min) 24 h before coronary occlusion. Sevoflurane (0.5 minimum alveolar concentration) or 5HD (5 mg/kg) were administered before myocardial ischemia. Myocardial infarct size and the area at risk for ischemia were measured, and heat shock protein (Hsp) 70 levels in each experimental group were determined. Compared with vehicle only, GGA significantly reduced the size of myocardial infarction in relation to the area at risk (39 +/- 10% vs 59 +/- 9%, P < 0.02). Sevoflurane enhanced the GGA-induced cardioprotection (23 +/- 17%, P < 0.05 vs GGA). The cardioprotective effect of GGA was abolished by administration of 5HD (56 +/- 15%, P < 0.01). GGA enhanced Hsp 70 expression compared with that in the control group (0.69 +/- 0.15 vs 0.36 +/- 0.05, P < 0.02). Administration of GGA with sevoflurane resulted in the same level of Hsp 70 expression as GGA (0.69 +/- 0.16, P > 0.98). GGA appears to reduce myocardial infarct size in association with increased Hsp 70 expression. Sevoflurane enhances the GGA-induced cardioprotective effect. (キーワード) Administration, Inhalation / Animals / Anti-Ulcer Agents / Cardiotonic Agents / Coronary Vessels / Diterpenes / Drug Synergism / HSP70 Heat-Shock Proteins / Hemodynamics / Male / Methyl Ethers / Myocardial Infarction / Protein Kinase C / Rabbits / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1213/ane.0b013e31817f0e61 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18713879 ● Search Scopus @ Elsevier (PMID): 18713879 ● Search Scopus @ Elsevier (DOI): 10.1213/ane.0b013e31817f0e61 (DOI: 10.1213/ane.0b013e31817f0e61, PubMed: 18713879)
52.	Nitta Kazuhito, Shinji Kawahito, Hiroshi Kitahata, Junpei Nozaki, Tosiko Katayama and Shuzo Oshita : Two unusual complications associated with cardiopulmonary bypass for pediatric cardiac surgery detected by transesophageal echocardiography after decannulation., Paediatric Anaesthesia, Vol.18, No.4, 325-329, 2008. (要約) We describe two rare cases of complications associated with cannulation for cardiopulmonary bypass during pediatric cardiac surgery detected by transesophageal echocardiography (TEE). The first patient (a 20-month-old boy, 11 kg) was scheduled for complete repair of an atrial septal defect and partial anomalous pulmonary venous connection. After decannulation of the superior vena cava, a mosaic jet was observed by means of TEE. The second patient (an 11-month-old boy, 6.4 kg), with a double outlet right ventricle, was scheduled for a hemi-Fontan procedure. After decannulation of the ascending aorta, high blood flow velocity of 4 m x s(-1) was detected by TEE. Intraoperative TEE was useful for early detection of complications associated with cardiopulmonary bypass cannulation during pediatric cardiac surgery. (キーワード) Aorta / Blood Flow Velocity / Blood Pressure / Cardiac Surgical Procedures / Cardiopulmonary Bypass / Catheterization / Central Venous Pressure / Constriction, Pathologic / Echocardiography, Doppler, Color / Echocardiography, Transesophageal / Fontan Procedure / Heart Septal Defects, Atrial / Humans / Infant / Male / Monitoring, Physiologic / Postoperative Complications / Pulmonary Veins / Vena Cava, Superior (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1460-9592.2008.02437.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18315639 ● Search Scopus @ Elsevier (PMID): 18315639 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1460-9592.2008.02437.x (DOI: 10.1111/j.1460-9592.2008.02437.x, PubMed: 18315639)
53.	Akemi Yamanaka, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : Intraoperative transesophageal ventricular pacing in pediatric patients., Journal of Cardiothoracic and Vascular Anesthesia, Vol.22, No.1, 92-94, 2008. (キーワード) Atrioventricular Block / Bradycardia / Cardiac Pacing, Artificial / Child / Echocardiography, Transesophageal / Female / Heart Defects, Congenital / Heart Ventricles / Humans / Infant, Newborn / Intraoperative Care / Male / Tetralogy of Fallot / Treatment Outcome / Ultrasonography, Interventional (出版サイトへのリンク) ● Publication site (DOI): 10.1053/j.jvca.2006.09.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18249338 ● Search Scopus @ Elsevier (PMID): 18249338 ● Search Scopus @ Elsevier (DOI): 10.1053/j.jvca.2006.09.004 (DOI: 10.1053/j.jvca.2006.09.004, PubMed: 18249338)
54.	Shinji Kawahito, Hiroshi Kitahata, Tetsuya Kitagawa, Shuzo Oshita and Nose Yukihiko : Non-cardiac surgery applications of extracorporeal circulation, The Journal of Medical Investigation : JMI, Vol.54, No.3,4, 200-210, 2007. (要約) Although the efficacy of extracorporeal circulation (ECC) is well established for open-heart surgery, application of ECC in other surgical areas has not been given much attention. Advances in the related surgical technique and anesthetic management combined with refinements in the ECC procedure itself have encouraged several institutions to use ECC for complex non-cardiac surgeries. ECC is beginning to be used for circulatory support or tissue oxygenation during surgery on the lung, brain, liver, and kidney as well as in emergency situations. With ECC, difficult and complex surgeries can be performed more safely, and the success rate of certain surgeries has been positively affected. It is important that the surgeon, anesthesiologist, and perfusionist are trained in non-cardiac surgery applications of ECC. Thus, we review here non-cardiac uses that have emerged and summarize the related procedures. (キーワード) Digestive System Surgical Procedures / Extracorporeal Circulation / Humans / Neurosurgical Procedures / Pulmonary Surgical Procedures / Urologic Surgical Procedures (徳島大学機関リポジトリ) ● Metadata: 111515 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.54.200 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17878668 ● Search Scopus @ Elsevier (PMID): 17878668 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.200 (徳島大学機関リポジトリ: 111515, DOI: 10.2152/jmi.54.200, PubMed: 17878668)
55.	Nakamura Akiyo, Shinji Kawahito, Takashi Kawano, Nazari Hossein, Akira Takahashi, Hiroshi Kitahata, Yutaka Nakaya and Shuzo Oshita : Differential Effects of Etomidate and Midazolam on Vascular Adenosine Triphosphate-sensitive Potassium Channels: Isometric Tension and Patch Clamp Studies., Anesthesiology, Vol.106, No.3, 515-522, 2007. (要約) The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. In isolated rat aorta, isometric tension was recorded to examine the anesthetic effects on vasodilator response to levcromakalim, a selective KATP channel opener. Using the patch clamp method, the anesthetic effects were also examined on the currents through (1) native vascular KATP channels, (2) recombinant KATP channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits, (3) SUR-deficient channels derived from a truncated isoform of Kir6.2 subunit (Kir6.2DeltaC36 channels), and (4) mutant Kir6.2DeltaC36 channels with reduced sensitivity to adenosine triphosphate (Kir6.2DeltaC36-K185Q channels). Etomidate (> or = 10 m), but not midazolam (up to 10 m), inhibited the levcromakalim-induced vasodilation, which was sensitive to glibenclamide (IC50: 7.21 x 10 m; maximum inhibitory concentration: 1.22 x 10 m). Etomidate (> or = 3 x 10 m), but not midazolam (up to 10 m), inhibited the native KATP channel activity in both cell-attached and inside-out configurations with IC50 values of 1.68 x 10 m and 1.52 x 10 m, respectively. Etomidate (10 m) also inhibited the activity of various types of recombinant SUR/Kir6.0KATP channels, Kir6.2DeltaC36 channels, and Kir6.2DeltaC36-K185Q channels with equivalent potency. Clinical concentrations of etomidate, but not midazolam, inhibit the KATP channel activity in vascular smooth muscle cells. The inhibition is presumably through its effects on the Kir6.0 subunit, but not on the SUR subunit, with the binding site different from adenosine triphosphate at the amino acid level. (キーワード) ATP-Binding Cassette Transporters / Adenosine Triphosphate / Anesthetics, Intravenous / Animals / Aorta, Thoracic / Cells, Cultured / Cromakalim / Dose-Response Relationship, Drug / Electrophysiology / Etomidate / Glyburide / Isometric Contraction / Male / Midazolam / Myocytes, Smooth Muscle / Organ Culture Techniques / Patch-Clamp Techniques / Potassium Channels / Potassium Channels, Inwardly Rectifying / Rats / Rats, Wistar / Receptors, Drug / Transfection / Vasodilation / Vasodilator Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200703000-00016 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17325510 ● Search Scopus @ Elsevier (PMID): 17325510 ● Search Scopus @ Elsevier (DOI): 10.1097/00000542-200703000-00016 (DOI: 10.1097/00000542-200703000-00016, PubMed: 17325510)
56.	片山俊子, 新田一仁, 川人伸次, 田中克哉, 松本幸久, 土井俊彦, 北畑洋, 大下修造 : 胸部下行大動脈ステントグラフト留置術における術中経食道心エコーの有用性, 麻酔, Vol.55, No.7, 886-891, 2006年. (要約) Stent graft implantation for thoracic descending aorta is a promising alternative to open repair. Transesophageal echocardiography (TEE) is a sensitive imaging modality for aortic disease. We reviewed our experience with TEE in stent graft implantation for thoracic descending aorta. Five patients underwent stent graft implantation for thoracic descending aorta under general anesthesia. Intraoperative angiography and TEE were used to identify the extent of the aneurysm and the placement of the stent. TEE showed stent graft configuration and presence of leakage in all cases. In three cases, additional stent graft placement or bypass was performed. Useful information was obtained by TEE in enhancing the accuracy of stent graft positioning potentially improving outcomes. TEE may facilitate repair by confirming aortic pathology, identifying endograft placement, and assessing the adequacy of aneurysm sack isolation, presence of leakage, as well as dynamic intraoperative cardiac performance. (キーワード) 胸部下行動脈 / transesophageal echocardiograpy / stent graft implantation / thoracic descending aorta (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16856550 ● CiNii @ 国立情報学研究所 (CRID): 1520853832758320896 ● Search Scopus @ Elsevier (PMID): 16856550 (PubMed: 16856550, CiNii: 1520853832758320896)
57.	中村明代, 川人伸次, 片山俊子, 河野崇, 新田一仁, 乾大資, 北畑洋, 大下修造 : 気管支痙攣を繰り返したPena-Shokeir症候群の麻酔管理, 麻酔, Vol.54, No.10, 1146-1148, 2005年. (要約) A 3-month-old boy with Pena-Shokeir syndrome underwent tracheotomy under general anesthesia. Patients with this syndrome may present anesthetic problems involving difficulties in tracheal intubation, possibilities of malignant hyperthermia, as well as perioperative respiratory complications related to hypoplasia of the lung. General anesthesia was induced and maintained with sevoflurane (2-3%) and nitrous oxide (0-50%) in oxygen (50-100%). The patient developed bronchospasm during tracheotomy. Atropine and epinephrine were administered intravenously and 5% sevoflurane was inhaled. The bronchospasm was improved gradually and surgery was successfully finished. Pena-Shokeir syndrome is an uncommon disease first reported by Pena & Shokeir in 1974 and characterized by congenital multiple arthrogryposis, characteristic facies, camptodactyly and pulmonary hypoplasia. In the perioperative management for a patient with Pena-Shokeir syndrome, special attention should be paid to abnormalities in the upper and lower respiratory systems, especially bronchospasm. (キーワード) 致死性先天奇形 / 多発性関節拘縮 / 呼吸管理 / Pena-Shokeir syndrome / lethal congenital anomalies / multiple arthrogryposis / respiratory management / bronchospasm (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16231771 ● CiNii @ 国立情報学研究所 (CRID): 1520853832602990592 ● Search Scopus @ Elsevier (PMID): 16231771 (PubMed: 16231771, CiNii: 1520853832602990592)
58.	川人伸次, 北畑洋 : きれいで正確な心エコー画像の描出, --- ー小児経食道心エコー画像を正しく描出するにはー ---, 日本臨床麻酔学会誌, Vol.25, No.5, 533-542, 2005年.
59.	Mikiko Inatsugi, Katsuya Tanaka, Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito and Shuzo Oshita : Minute distance obtained from pulmonary venous flow velocity using transesophageal pulsed Doppler echocardiography is related to cardiac output during cardiovascular surgery, The Journal of Medical Investigation : JMI, Vol.52, No.3,4, 178-185, 2005. (要約) We studied the relationship between minute distance calculated from pulmonary venous flow (PVF) velocity tracing and cardiac output (CO) measured with thermodilution method in patients undergoing cardiovascular surgery. In 32 patients undergoing cardiovascular surgery, simultaneous measurements of hemodynamics including CO and transesophageal pulsed Doppler signals of PVF velocity were performed before and after surgical repair. Minute distance was calculated as the product of the heart rate and the sum of time-velocity integrals of PVF. The minute distance after surgical intervention increased from 1121 +/- 347 cm x sec(-1) to 1764 +/- 538 cm x sec(-1) (p < 0.001; mean +/- SD), while CO increased after surgical intervention from 3.5 +/- 0.9 L x min(-1) to 5.3 +/- 1.1 L x min(-1). Simple linear regression analysis showed that minute distance was related with CO before and after surgical intervention (r = 0.81 and r = 0.76, respectively). The changes in minute distance were also related with those in CO (r = 0.80). The present study demonstrated that minute distance obtained from the pulsed Doppler tracings of PVF velocity was related with CO during cardiovascular surgery in adults. These results suggest that the changes in CO could be estimated from minute distance in pulmonary vein. (キーワード) Aged / Blood Flow Velocity / Cardiac Output / Cardiovascular Surgical Procedures / Echocardiography, Doppler, Pulsed / 経食道心エコー (transesophageal echocardiography) / Humans / Male / Middle Aged / Monitoring, Intraoperative / Pulmonary Circulation / Pulmonary Veins / Thermodilution (徳島大学機関リポジトリ) ● Metadata: 110775 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.52.178 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16167536 ● Search Scopus @ Elsevier (PMID): 16167536 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.52.178 (徳島大学機関リポジトリ: 110775, DOI: 10.2152/jmi.52.178, PubMed: 16167536)
60.	Mikiyo Yamaguchi, Yoshinobu Tomiyama, Tosiko Katayama, Hiroshi Kitahata and Shuzo Oshita : Involvement of adenosine triphosphate-sensitive potassium channels in the response of membrane potential to hyperosmolality in cultured human aorta endothelial cells., Anesthesia & Analgesia, Vol.100, No.2, 419-426, 2005. (要約) The membrane potential of endothelial cells is an important determinant of endothelial functions, including regulation of vascular tone. We investigated whether adenosine triphosphate-sensitive potassium (K(ATP)) channels were involved in the response of membrane potential to hyperosmolality in cultured human aorta endothelial cells. The voltage-sensitive fluorescent dye, bis-(1,3-diethylthiobarbiturate)trimethine oxonol, was used to assess relative changes in membrane potential semiquantitatively. To investigate the effect of mannitol-, sucrose-, and NaCl-induced hyperosmolality on membrane potential, cells were continuously perfused with Earle's balanced salt solution (285 mOsm/kg H(2)O) containing 200 nM bis-(1,3-diethylthiobarbiturate)trimethine oxonol and exposed to 315 and 345 mOsm/kg H(2)O hyperosmotic medium sequentially in the presence and absence of 1 muM glibenclamide, a well-known K(ATP) channel blocker. Hyperosmotic mannitol significantly induced hyperpolarization of the endothelial cells, which was prevented by 1 microM glibenclamide (n = 6). Estimated changes of membrane potential at 315 and 345 mOsm/kg H(2)O were 13 +/- 8 and 21 +/- 8 mV, respectively. Hypertonic sucrose induced similar changes. However, although hypertonic saline also significantly induced hyperpolarization of the endothelial cells (n = 6), the hyperpolarization was not prevented by 1 muM glibenclamide. In conclusion, K(ATP) channels may participate in hyperosmotic mannitol- and sucrose-induced hyperpolarization, but not in hypertonic saline-induced hyperpolarization in cultured human aorta endothelial cells. (キーワード) ATP-Binding Cassette Transporters / Aorta / 校正 (calibration) / Cells, Cultured / Cromakalim / Diuretics, Osmotic / Endothelial Cells / Fluorescent Dyes / Glyburide / Humans / Hypoglycemic Agents / Indicators and Reagents / KATP Channels / Mannitol / Membrane Potentials / Osmolar Concentration / Perfusion / Potassium Channels / Potassium Channels, Inwardly Rectifying / Sodium Chloride / Sucrose / Thiobarbiturates / Vasodilator Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1213/01.ANE.0000143350.82645.5B (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15673869 ● Search Scopus @ Elsevier (PMID): 15673869 ● Search Scopus @ Elsevier (DOI): 10.1213/01.ANE.0000143350.82645.5B (DOI: 10.1213/01.ANE.0000143350.82645.5B, PubMed: 15673869)
61.	Takashi Kawano, Shuzo Oshita, Akira Takahashi, Y Tsutsumi, Katsuya Tanaka, Yoshinobu Tomiyama, Hiroshi Kitahata and Yutaka Nakaya : Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels., Anesthesiology, Vol.102, No.1, 93-101, 2005. (要約) Ketamine inhibits adenosine triphosphate-sensitive potassium (KATP) channels, which results in the blocking of ischemic preconditioning in the heart and inhibition of vasorelaxation induced by KATP channel openers. In the current study, the authors investigated the molecular mechanisms of ketamine's actions on sarcolemmal KATP channels that are reassociated by expressed subunits, inwardly rectifying potassium channels (Kir6.1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B). The authors used inside-out patch clamp configurations to investigate the effects of ketamine on the activities of reassociated Kir6.0/SUR channels containing wild-type, mutant, or chimeric SURs expressed in COS-7 cells. Ketamine racemate inhibited the activities of the reassociated KATP channels in a SUR subtype-dependent manner: SUR2A/Kir6.2 (IC50 = 83 microM), SUR2B/Kir6.1 (IC50 = 77 microM), SUR2B/Kir6.2 (IC50 = 89 microM), and SUR1/Kir6.2 (IC50 = 1487 microM). S-(+)-ketamine was significantly less potent than ketamine racemate in blocking all types of reassociated KATP channels. The ketamine racemate and S-(+)-ketamine both inhibited channel currents of the truncated isoform of Kir6.2 (Kir6.2DeltaC36) with very low affinity. Application of 100 mum magnesium adenosine diphosphate significantly enhanced the inhibitory potency of ketamine racemate. The last transmembrane domain of SUR2 was essential for the full inhibitory effect of ketamine racemate. These results suggest that ketamine-induced inhibition of sarcolemmal KATP channels is mediated by the SUR subunit. These inhibitory effects of ketamine exhibit specificity for cardiovascular KATP channels, at least some degree of stereoselectivity, and interaction with intracellular magnesium adenosine diphosphate. (キーワード) ATP-Binding Cassette Transporters / Adenosine Diphosphate / Animals / COS Cells / Cercopithecus aethiops / DNA, Complementary / Excitatory Amino Acid Antagonists / KATP Channels / Ketamine / Mutation / Patch-Clamp Techniques / Potassium Channel Blockers / Potassium Channels / Potassium Channels, Inwardly Rectifying / Rats / Recombinant Fusion Proteins / Sarcolemma / Stereoisomerism / Transfection (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200501000-00017 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15618792 ● Search Scopus @ Elsevier (PMID): 15618792 ● Search Scopus @ Elsevier (DOI): 10.1097/00000542-200501000-00017 (DOI: 10.1097/00000542-200501000-00017, PubMed: 15618792)
62.	Yuka Jinnouchi, Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Anesthetic management of a patient undergoing cardioverter defibrillator implantation: usefulness of transesophageal echocardiography and near infrared spectroscopy., Journal of Anesthesia, Vol.18, No.3, 220-223, 2004. (キーワード) Anesthetic management / Implantable cardioverter defibrillator / Transesophageal echocardiography / Near infrared spectroscopy (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-004-0243-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15290423 ● CiNii @ 国立情報学研究所 (CRID): 1573950399847311360 ● Search Scopus @ Elsevier (PMID): 15290423 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-004-0243-7 (DOI: 10.1007/s00540-004-0243-7, PubMed: 15290423, CiNii: 1573950399847311360)
63.	Takashi Kawano, Shuzo Oshita, Akira Takahashi, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Yutaka Nakaya : Molecular Mechanisms of the Inhibitory Effects of Bupivacaine, Levobupivacaine, and Ropivacaine on Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channels in the Cardiovascular System., Anesthesiology, Vol.101, No.2, 390-398, 2004. (要約) Sarcolemmal adenosine triphosphate-sensitive potassium (KATP) channels in the cardiovascular system may be involved in bupivacaine-induced cardiovascular toxicity. The authors investigated the effects of local anesthetics on the activity of reconstituted KATP channels encoded by inwardly rectifying potassium channel (Kir6.0) and sulfonylurea receptor (SUR) subunits. The authors used an inside-out patch clamp configuration to investigate the effects of bupivacaine, levobupivacaine, and ropivacaine on the activity of reconstituted KATP channels expressed in COS-7 cells and containing wild-type, mutant, or chimeric SURs. Bupivacaine inhibited the activities of cardiac KATP channels (IC50 = 52 microm) stereoselectively (levobupivacaine, IC50 = 168 microm; ropivacaine, IC50 = 249 microm). Local anesthetics also inhibited the activities of channels formed by the truncated isoform of Kir6.2 (Kir6.2 delta C36) stereoselectively. Mutations in the cytosolic end of the second transmembrane domain of Kir6.2 markedly decreased both the local anesthetics' affinity and stereoselectivity. The local anesthetics blocked cardiac KATP channels with approximately eightfold higher potency than vascular KATP channels; the potency depended on the SUR subtype. The 42 amino acid residues at the C-terminal tail of SUR2A, but not SUR1 or SUR2B, enhanced the inhibitory effect of bupivacaine on the Kir6.0 subunit. Inhibitory effects of local anesthetics on KATP channels in the cardiovascular system are (1) stereoselective: bupivacaine was more potent than levobupivacaine and ropivacaine; and (2) tissue specific: local anesthetics blocked cardiac KATP channels more potently than vascular KATP channels, via the intracellular pore mouth of the Kir6.0 subunit and the 42 amino acids at the C-terminal tail of the SUR2A subunit, respectively. (キーワード) ATP-Binding Cassette Transporters / Algorithms / Amides / Anesthetics, Local / Animals / Bupivacaine / COS Cells / Cercopithecus aethiops / Dose-Response Relationship, Drug / Membrane Potentials / Membrane Proteins / Patch-Clamp Techniques / Potassium Channel Blockers / Potassium Channels / Potassium Channels, Inwardly Rectifying / Receptors, Drug / Stereoisomerism / Sulfonylurea Compounds / Transfection (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200408000-00020 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15277922 ● Search Scopus @ Elsevier (PMID): 15277922 ● Search Scopus @ Elsevier (DOI): 10.1097/00000542-200408000-00020 (DOI: 10.1097/00000542-200408000-00020, PubMed: 15277922)
64.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Risk factors for perioperative myocardial ischemia in carotid artery endarterectomy., Journal of Cardiothoracic and Vascular Anesthesia, Vol.18, No.3, 288-292, 2004. (要約) To identify variables associated with perioperative myocardial ischemia in patients undergoing carotid artery endarterectomy (CEA). Prospective, observational study. University-affiliated hospital operating room and intensive care unit. One hundred twenty-eight consecutive patients who underwent CEA during a 7-year period. Patients had general anesthesia with sevoflurane or isoflurane. CEA was performed by standard methods with shunting if clinically indicated. Holter electrocardiogram (ECG) monitoring was performed during surgery and 24 hours after surgery. The incidence of perioperative myocardial ischemia was examined, and perioperative risk factors were analyzed. Nineteen patients (15%) showed significant perioperative ECG abnormalities indicative of myocardial ischemia (10 patients during surgery, 12 patients after surgery, and 3 patients both during and after surgery). Multivariate analysis showed perioperative myocardial ischemia to be significantly associated with a history of angina (odds ratio, 11.68; 95% confidence interval, 2.64-51.70) and a history of hypertension (odds ratio, 14.08; 95% confidence interval, 1.51-131.04). The data indicate that perioperative myocardial ischemia defined as an ECG abnormality does not often occur in patients undergoing CEA. However, angina and hypertension may be important risk factors warranting further investigation. (キーワード) Adult / Aged / Anesthesia, General / Electrocardiography / Endarterectomy, Carotid / Female / Humans / Male / Middle Aged / Monitoring, Intraoperative / Multivariate Analysis / Myocardial Ischemia / Risk Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1053/j.jvca.2004.03.007 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15232807 ● Search Scopus @ Elsevier (PMID): 15232807 ● Search Scopus @ Elsevier (DOI): 10.1053/j.jvca.2004.03.007 (DOI: 10.1053/j.jvca.2004.03.007, PubMed: 15232807)
65.	Takako Masuda, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita : Effect of propofol on hypotonic swelling-induced membrane depolarization in human coronary artery smooth muscle cells., Anesthesiology, Vol.100, No.3, 648-656, 2004. (要約) Stretch (mechanical stress)-induced membrane depolarization of smooth muscle may contribute to basal vascular tone and myogenic control. Propofol induces vasodilation and inhibits myogenic control. Hypotonic swelling was used as a model of mechanical stress. The authors investigated the effects of propofol and 5-nitro-2-(3-phenylpropylamino)benzoic acid, a chloride channel and nonselective cation channel blocker, on hypotonicity-induced membrane depolarization in cultured human coronary artery smooth muscle cells. A voltage-sensitive fluorescent dye, bis-(1,3-diethylthiobarbiturate)trimethine oxonol, was used to assess relative changes in membrane potential semiquantitatively. The cells were continuously perfused with Earle's balanced salt solution containing 200 nM bis-(1,3-diethylthiobarbiturate)trimethine oxonol and exposed sequentially to isotonic and hypotonic medium. In a second series of experiments, the cells were exposed to hypotonic media in the presence and absence of 5-nitro-2-(3-phenylpropylamino)benzoic acid or propofol. The relative fluorescence values at 10, 20, and 30% hypotonicity were 147 +/- 29, 214 +/- 74, and 335 +/- 102% of baseline, respectively. The changes were all significantly different from the isotonic time control group. In the presence of 200 microM 5-nitro-2-(3-phenylpropylamino)benzoic acid or 0.1, 1, 10, or 100 microg/ml propofol, the relative fluorescence values at 30% hypotonicity were 87 +/- 17, 194 +/- 27, 160 +/- 18, 130 +/- 18, and 84 +/- 15%, respectively. These changes were significantly less than the 30% for the hypotonic control (246 +/- 23%). These results suggest that volume-sensitive chloride channels and nonselective cation channels may participate in hypotonicity-induced membrane depolarization and that propofol inhibits hypotonicity-induced membrane depolarization in coronary artery smooth muscle. (キーワード) Anesthetics, Intravenous / Calibration / Cells, Cultured / Chloride Channels / Coronary Vessels / Fluorescent Dyes / Humans / Hydrogen-Ion Concentration / Hypotonic Solutions / Ion Channels / Membrane Potentials / Muscle, Smooth, Vascular / Nitrobenzoates / Perfusion / Potassium / Propofol / Sodium (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200403000-00027 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15108981 ● Search Scopus @ Elsevier (PMID): 15108981 ● Search Scopus @ Elsevier (DOI): 10.1097/00000542-200403000-00027 (DOI: 10.1097/00000542-200403000-00027, PubMed: 15108981)
66.	Takashi Kawano, Shuzo Oshita, Akira Takahashi, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Yutaka Nakaya : Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels., Anesthesiology, Vol.100, No.2, 338-346, 2004. (要約) Both propofol and thiamylal inhibit adenosine triphosphate-sensitive potassium (KATP) channels. In the current study, the authors investigated the effects of these anesthetics on the activity of recombinant sarcolemmal KATP channels encoded by inwardly rectifying potassium channel (Kir6.1 or Kir6.2) genes and sulfonylurea receptor (SUR1, SUR2A, or SUR2B) genes. The authors used inside-out patch clamp configurations to investigate the effects of propofol and thiamylal on the activity of recombinant KATP channels using COS-7 cells transfected with various types of KATP channel subunits. Propofol inhibited the activities of the SUR1/Kir6.2 (EC50 = 77 microm), SUR2A/Kir6.2 (EC50 = 72 microm), and SUR2B/Kir6.2 (EC50 = 71 microm) channels but had no significant effects on the SUR2B/Kir6.1 channels. Propofol inhibited the truncated isoform of Kir6.2 (Kir6.2DeltaC36) channels (EC50 = 78 microm) that can form functional KATP channels in the absence of SUR molecules. Furthermore, the authors identified two distinct mutations R31E (arginine residue at position 31 to glutamic acid) and K185Q (lysine residue at position 185 to glutamine) of the Kir6.2DeltaC36 channel that significantly reduce the inhibition of propofol. In contrast, thiamylal inhibited the SUR1/Kir6.2 (EC50 = 541 microm), SUR2A/Kir6.2 (EC50 = 248 microm), SUR2B/Kir6.2 (EC50 = 183 microm), SUR2B/Kir6.1 (EC50 = 170 microm), and Kir6.2DeltaC36 channels (EC50 = 719 microm). None of the mutants significantly affects the sensitivity of thiamylal. These results suggest that the major effects of both propofol and thiamylal on KATP channel activity are mediated via the Kir6.2 subunit. Site-directed mutagenesis study suggests that propofol and thiamylal may influence Kir6.2 activity by different molecular mechanisms; in thiamylal, the SUR subunit seems to modulate anesthetic sensitivity. (キーワード) ATP-Binding Cassette Transporters / Anesthetics, Intravenous / Animals / Cells, Cultured / Diazoxide / Electrophysiology / Glyburide / Humans / Molecular Biology / Patch-Clamp Techniques / Pinacidil / Potassium Channels / Potassium Channels, Inwardly Rectifying / Propofol / Rats / Receptors, Drug / Thiamylal / Vasodilator Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200402000-00024 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14739809 ● Search Scopus @ Elsevier (PMID): 14739809 ● Search Scopus @ Elsevier (DOI): 10.1097/00000542-200402000-00024 (DOI: 10.1097/00000542-200402000-00024, PubMed: 14739809)
67.	Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Junpei Nozaki, Yoshinobu Tomiyama and Shuzo Oshita : Phenylephrine increases pulmonary blood flow in children with tetralogy of Fallot., Canadian Journal of Anaesthesia, Vol.50, No.9, 926-929, 2003. (要約) Although it has been reported that the increase in blood pressure improves arterial oxygen saturation (SaO(2)) in children with tetralogy of Fallot, no prospective study has demonstrated that an increase in blood pressure induces an increase in pulmonary blood flow in these patients. The purpose of this study was to see whether a phenylephrine-induced increase in systemic blood pressure increased pulmonary blood flow, resulting in improved arterial oxygenation in tetralogy of Fallot. In 14 consecutive children with tetralogy of Fallot (2-32 months old), transesophageal pulsed Doppler signals of left upper pulmonary venous flow (PVF) velocity were recorded before and four minutes after 10 micro g x kg(-1) of phenylephrine i.v. Simultaneously, arterial blood gas analysis and hemodynamic measurements were performed. The minute distance (MD) was calculated as the product of the heart rate and the sum of time-velocity integrals of PVF. Phenylephrine iv increased mean arterial blood pressure from 54 +/- 8 mmHg to 73 +/- 10 mmHg. This phenylephrine-induced hypertension significantly increased SaO(2) and MD (92.0 +/- 7.5 vs 95.0 +/- 5.0% and 1318 +/- 344 vs 1533 +/- 425 cm x min(-1), respectively). There was a significant correlation (r = 0.72) between the change in MD and the change in SaO(2). Our results suggest that the phenylephrine-induced increase in systemic blood pressure produces an increase in pulmonary blood flow in tetralogy of Fallot. Our results further suggest that this increase in pulmonary blood flow is involved in the mechanism of phenylephrine-induced improvement of arterial oxygenation in tetralogy of Fallot. (キーワード) Blood Flow Velocity / Blood Gas Analysis / 子ども (children) / Child, Preschool / Echocardiography, Doppler, Pulsed / 経食道心エコー (transesophageal echocardiography) / Female / Hemodynamics / Humans / Hypertension / 小児 (infant) / Male / Oxygen / Phenylephrine / Pulmonary Circulation / Pulmonary Veins / Tetralogy of Fallot / Vasoconstrictor Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF03018741 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14617591 ● Search Scopus @ Elsevier (PMID): 14617591 ● Search Scopus @ Elsevier (DOI): 10.1007/BF03018741 (DOI: 10.1007/BF03018741, PubMed: 14617591)
68.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Intraoperative transoesophageal echocardiography in a low birth weight neonate with atrioventricular septal defect., Paediatric Anaesthesia, Vol.13, No.8, 735-738, 2003. (要約) An 18-day-old male neonate (45 cm, 1.8 kg) with a history of cyanosis and congestive heart failure from an atrioventricular septal defect (AVSD) with a large left-to-right shunt was scheduled for surgical repair of the AVSD. After routine induction of anaesthesia with fentanyl and vecuronium, a 4.5-mm diameter transoesophageal echocardiography (TOE) probe was inserted into the oesophagus, and systematic echocardiographic evaluation was performed during surgery. After cardiopulmonary bypass was stopped, intraoperative TOE revealed mild residual mitral valve regurgitation. Because good left ventricular wall motion was confirmed and haemodynamic parameters were stable, cardiopulmonary bypass was not reinitiated. The patient's cardiac output was low in the postoperative intensive care unit. TOE was performed the next day to detect the source of this problem, revealed severe regurgitation compared with that observed intraoperatively. TOE was useful for evaluation of the residual mitral valve regurgitation, and we reconfirmed the importance of continuous monitoring even in a low birthweight neonate undergoing repair of a complete AVSD. (キーワード) Echocardiography, Transesophageal / Fatal Outcome / Heart Atria / Heart Septal Defects / Heart Ventricles / Humans / Infant, Low Birth Weight / Infant, Newborn / Male / Mitral Valve Insufficiency / Monitoring, Intraoperative / Postoperative Complications (出版サイトへのリンク) ● Publication site (DOI): 10.1046/j.1460-9592.2003.01121.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14535917 ● Search Scopus @ Elsevier (PMID): 14535917 ● Search Scopus @ Elsevier (DOI): 10.1046/j.1460-9592.2003.01121.x (DOI: 10.1046/j.1460-9592.2003.01121.x, PubMed: 14535917)
69.	Takako Masuda, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita : Propofol inhibits volume-sensitive chloride channels in human coronary artery smooth muscle cells., Anesthesia & Analgesia, Vol.97, No.3, 657-662, 2003. (要約) Volume-sensitive chloride channels (VSCC) play an important role in regulation of cell volume and electrical activity. Activation of vascular smooth muscle VSCC causes smooth muscle depolarization and contraction. We investigated the effects of propofol on VSCC in cultured human coronary artery smooth muscle cells by using the chloride-sensitive dye 6-methoxy-N-ethylquinolinium (MEQ). To activate VSCC, cells were superfused for 2 min with hypotonic gluconate solutions and then potassium thiocyanate solution. The percentage reduction in MEQ fluorescence during 60 s in the presence of potassium thiocyanate was measured and used as an index of VSCC activity. 5-Nitro-2-(3-phenylpropylamino) benzoic acid (NPPB), a well characterized chloride channel blocker, and propofol were dissolved in hypotonic gluconate solution to test their effect on VSCC activity. The reduction in fluorescence was inversely related to osmolality, indicating that activation of VSCC is osmolality dependent. Hypotonic gluconate solution (210 mOsm/kg H(2)O) reduced fluorescence by 38.9% +/- 2.6% of the baseline value. The reduction in fluorescence was dose-dependently inhibited by NPPB. Propofol at 0.3, 1, 3, 10, 30, and 100 micro g/mL significantly inhibited the reduction in fluorescence to 23.6% +/- 4.8%, 19.7% +/- 7.4%, 18.2% +/- 3.5%, 17.6% +/- 5.0%, 15.8% +/- 3.1%, and 10.3% +/- 3.9% of the baseline value, respectively. Our results indicate that propofol inhibits VSCC in a dose-dependent manner in human coronary artery smooth muscle cells. (キーワード) Anesthetics, Intravenous / Cells, Cultured / Chloride Channels / Coronary Vessels / Fluorescent Dyes / Humans / Microscopy, Fluorescence / Muscle, Smooth, Vascular / Nitrobenzoates / Osmolar Concentration / Propofol (出版サイトへのリンク) ● Publication site (DOI): 10.1213/01.ANE.0000076060.48760.BD (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12933379 ● Search Scopus @ Elsevier (PMID): 12933379 ● Search Scopus @ Elsevier (DOI): 10.1213/01.ANE.0000076060.48760.BD (DOI: 10.1213/01.ANE.0000076060.48760.BD, PubMed: 12933379)
70.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Dynamic QRS-complex and ST-segment monitoring by continuous vectorcardiography during carotid endarterectomy., British Journal of Anaesthesia, Vol.90, No.2, 142-147, 2003. (要約) Many authors report a high incidence of cardiac events during carotid endarterectomy. The aim of the present study was to evaluate the usefulness of dynamic continuous on-line vectorcardiography for monitoring the occurrence of myocardial ischaemia during carotid endarterectomy. We studied 21 patients undergoing carotid endarterectomy. Patients underwent general anaesthesia with isoflurane or sevoflurane. The vectorcardiogram was monitored continuously during carotid endarterectomy. Electrodes were placed according to the previously described lead system and connected to a computerized system for on-line vectorcardiography. Two trend variables were recorded: the QRS vector difference, which reflects changes in the shape of the QRS complex; and the ST vector magnitude, which represents deflection of the ST segment from the isoelectric level. The ST segment deflection was measured 60 ms after termination of the QRS complex. Vectorcardiography was successfully recorded in all 21 patients. Three patients showed intraoperative vectorcardiogram abnormalities. In one of these three patients, both ST vector magnitude and QRS vector difference increased after induction of anaesthesia and ST vector magnitude returned to baseline after administration of nitroglycerin. In the other two patients, both ST vector magnitude and QRS vector difference gradually increased after cross-clamping of the internal carotid artery and ST vector magnitude returned to baseline after unclamping. QRS vector difference remained elevated for several hours in all three patients. Monitoring ST vector magnitude and QRS vector difference by vectorcardiography may be useful for identifying myocardial ischaemia during carotid endarterectomy. (キーワード) Aged / Anesthesia, General / Endarterectomy, Carotid / Female / Humans / Intraoperative Complications / Male / Middle Aged / Monitoring, Intraoperative / Myocardial Ischemia / Vectorcardiography (出版サイトへのリンク) ● Publication site (DOI): 10.1093/bja/aeg031 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12538368 ● Search Scopus @ Elsevier (PMID): 12538368 ● Search Scopus @ Elsevier (DOI): 10.1093/bja/aeg031 (DOI: 10.1093/bja/aeg031, PubMed: 12538368)
71.	Junpei Nozaki, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : Effects of acute normovolemic hemodilution on ventriculoarterial coupling in dogs., Acta Anaesthesiologica Scandinavica, Vol.47, No.1, 46-52, 2003. (要約) Acute normovolemic hemodilution (ANH) causes a decrease in systemic vascular resistance. Similar to vasodilating drugs, ANH might modify ventriculoarterial coupling. Left ventricular elastance (Ees), effective arterial elastance (Ea), stroke work (SW), and pressure volume area (PVA) were used as indicators to examine the effects of ANH on this coupling. After institutional approval eight dogs were anesthetized with isoflurane and subjected to measurements including aortic pressure, left ventricular (LV) pressure, and LV volume. Left ventricular volume was measured with a conductance catheter. Ees was determined as the slope of the end-systolic pressure-volume relationship. Ea was determined as the ratio of LV end-systolic pressure to stroke volume. Ventriculoarterial coupling was evaluated as the ratio of Ees to Ea. Mechanical efficiency, another criterion for ventriculoarterial coupling, was calculated as the ratio of SW to PVA. Data are expressed as mean+/-SD, and P<0.05 was considered significant. Normovolemic exchange of 50 ml kg-1 of blood for 6% hydroxyethyl starch (ANH50) reduced hemoglobin concentration from 12.8+/-3.0 g dl-1 to 6.4+/-1.3 g dl-1. Acute normovolemic hemodilution 50 did not change Ees significantly although it significantly decreased Ea. Left ventricular elastance/Ea did not change after ANH (1.0+/-0.4 at baseline and 1.2+/-0.5 at ANH50). Acute normovolemic hemodilution 50 significantly increased SW and PVA, preventing SW/PVA from changing significantly after ANH (0.57+/-0.10 at baseline and 0.62+/-0.14 at ANH50). Before ANH, ventriculoarterial coupling was so matched as to maximize SW at the expense of the work efficiency. This relation was preserved at ANH50. (キーワード) Algorithms / Anesthesia / Animals / Arteries / Blood Gas Analysis / Blood Pressure / Blood Volume / Dogs / Elasticity / Female / Heart / Hemodilution / Male / Stroke Volume / Ventricular Function / Ventricular Function, Left (出版サイトへのリンク) ● Publication site (DOI): 10.1034/j.1399-6576.2003.470108.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12492796 ● Search Scopus @ Elsevier (PMID): 12492796 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1399-6576.2003.470108.x (DOI: 10.1034/j.1399-6576.2003.470108.x, PubMed: 12492796)
72.	Takashi Kawano, Shuzo Oshita, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda, Akira Takahashi and Yutaka Nakaya : Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes., Anesthesiology, Vol.96, No.6, 1472-1477, 2002. (要約) Activation of adenosine triphosphate-sensitive potassium (K(ATP)) channels produces cardioprotective effects during ischemia. Because propofol is often used in patients who have coronary artery disease undergoing a wide variety of surgical procedures, it is important to evaluate the direct effects of propofol on K(ATP) channel activities in ventricular myocardium during ischemia. The effects of propofol (0.4-60.1 microg/ml) on both sarcolemmal and mitochondrial K(ATP) channel activities were investigated in single, quiescent rat ventricular myocytes. Membrane currents were recorded using cell-attached and inside-out patch clamp configurations. Flavoprotein fluorescence was measured to evaluate mitochondrial oxidation mediated by mitochondrial K(ATP) channels. In the cell-attached configuration, open probability of K(ATP) channels was reduced by propofol in a concentration-dependent manner (EC(50) = 14.2 microg/ml). In the inside-out configurations, propofol inhibited K(ATP) channel activities without changing the single-channel conductance (EC(50) = 11.4 microg/ml). Propofol reduced mitochondrial oxidation in a concentration-dependent manner with an EC(50) of 14.6 microg/ml. Propofol had no effect on the sarcolemmal K(ATP) channel activities in patch clamp configurations and the mitochondrial flavoprotein fluorescence induced by diazoxide at clinically relevant concentrations (< 2 microm), whereas it significantly inhibited both K(ATP) channel activities at very high, nonclinical concentrations (> 5.6 microg/ml; 31 microm). (キーワード) アデノシン三リン酸 (adenosine triphosphate) / Anesthetics, Intravenous / Animals / Dose-Response Relationship, Drug / 心臓 (heart) / Heart Ventricles / Male / Mitochondria, Heart / Potassium Channels / Propofol / Rats / Rats, Wistar / Sarcolemma (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200206000-00029 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12170062 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036260435 (DOI: 10.1097/00000542-200206000-00029, PubMed: 12170062, Elsevier: Scopus)
73.	Junpei Nozaki, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : The effects of acute normovolemic hemodilution on left ventricular systolic and diastolic function in the absence or presence of beta-adrenergic blockade in dogs., Anesthesia & Analgesia, Vol.94, No.5, 1120-1126, 2002. (要約) Acute normovolemic hemodilution (ANH) increases cardiac output because of a reduction in blood viscosity and enhancement of left ventricular (LV) contractility. The status of LV function, especially LV diastolic function during ANH, remains controversial. We therefore examined LV systolic and diastolic function during ANH. Sixteen dogs were anesthetized with isoflurane in the absence (Group 1) and presence (Group 2) of beta-adrenergic blockade (propranolol 1 mg/kg). LV contractility was quantified by the slope (M(w)) of the stroke work and end-diastolic volume relation. Diastolic function was evaluated with the time constant of LV relaxation (T), chamber stiffness constant (K(c)), peak LV diastolic filling rate during early filling (peak E) and atrial contraction (peak A), and ratio of peak E to peak A (E/A). Normovolemic exchange of blood (50 mL/kg) for 6% hydroxyethyl starch (ANH50) significantly increased M(w) in Group 1 but not in Group 2. In both groups, ANH50 significantly decreased T. ANH50 significantly increased peak E in both groups and peak A in Group 1, and it did not change the E/A ratio or K(c) in either group. ANH causes positive inotropic effects and enhances diastolic function without beta-blockade. Even after beta-adrenergic blockade, ANH improves diastolic function through the reduction of LV ejection impedance. IMPLICATIONS: Acute normovolemic hemodilution enhances LV (left ventricular) diastolic function by alterations in the LV loading condition produced by hemodilution, which mainly contributes to a compensatory increase in cardiac output. (キーワード) PRESSURE-VOLUME RELATIONSHIPS / MYOCARDIAL RELAXATION / PRELOAD / CONTRACTILITY / DESFLURANE / ISOFLURANE / HALOTHANE / CATHETER / INDEXES / HUMANS (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000539-200205000-00011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11973172 ● Search Scopus @ Elsevier (PMID): 11973172 ● Search Scopus @ Elsevier (DOI): 10.1097/00000539-200205000-00011 (DOI: 10.1097/00000539-200205000-00011, PubMed: 11973172)
74.	Yasuo Tsutsumi, Shuzo Oshita, Takashi Kawano, Hiroshi Kitahata, Yoshinobu Tomiyama, Yasuhiro Kuroda and Yutaka Nakaya : Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, Vol.95, No.3, 766-770, 2001. (要約) Accumulating evidence suggests that mitochondrial rather than sarcolemmal adenosine triphosphate-sensitive K+ (K(ATP)) channels may have an important role in the protection of myocardium during ischemia. Because both lidocaine and mexiletine are frequently used antiarrhythmic drugs during myocardial ischemia, it is important to investigate whether they affect mitochondrial K(ATP) channel activities. Male Wistar rats were anesthetized with ether. Single, quiescent ventricular myocytes were dispersed enzymatically. The authors measured flavoprotein fluorescence to evaluate mitochondrial redox state. Lidocaine or mexiletine was applied after administration of diazoxide (25 microM), a selective mitochondrial K(ATP) channel opener. The redox signal was normalized to the baseline flavoprotein fluorescence obtained during exposure to 2,4-dinitrophenol, a protonophore that uncouples respiration from ATP synthesis and collapses the mitochondrial potential. Diazoxide-induced oxidation of flavoproteins and the redox changes were inhibited by 5-hydroxydecanoic acid, a selective mitochondrial K(ATP) channel blocker, suggesting that flavoprotein fluorescence can be used as an index of mitochondrial oxidation mediated by mitochondrial K(ATP) channels. Lidocaine (10(-3) to 10 mM) and mexiletine (10(-3) to 10 mM) reduced oxidation of the mitochondrial matrix in a dose-dependent manner with an EC50 of 98+/-63 microM for lidocaine and 107+/-89 microM for mexiletine. Both lidocaine and mexiletine reduced flavoprotein fluorescence induced by diazoxide in rat ventricular myocytes, indicating that these antiarrhythmic drugs may produce impairment of mitochondrial oxidation mediated by mitochondrial K(ATP) channels. (キーワード) Adenosine Triphosphate / Animals / Anti-Arrhythmia Agents / Calcium / Diazoxide / Heart Ventricles / Lidocaine / Male / Mexiletine / Mitochondria, Heart / Oxygen Consumption / Potassium Channels / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200109000-00032 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11575552 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034849904 (DOI: 10.1097/00000542-200109000-00032, PubMed: 11575552, Elsevier: Scopus)
75.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Pulmonary arterial pressure can be estimated by transesophageal pulsed Doppler echocardiography., Anesthesia & Analgesia, Vol.92, No.6, 1364-1369, 2001. (要約) We examined whether pulmonary arterial pressure can be estimated on the basis of pulmonary arterial flow velocity determined via intraoperative pulsed Doppler transesophageal echocardiography (TEE) in 20 patients undergoing cardiac surgery. Standard pulmonary artery measurements were taken as well. Measurements were taken before sternotomy, after pericardiotomy, after cardiopulmonary bypass, and after sternum closure. The variables obtained by TEE included preejection period (PEP), acceleration time (AT), right ventricular ejection time (RVET), and R-R interval (RR). Five ratios were calculated as indices of pulmonary arterial pressure--PEP/AT, PEP/RVET, AT/RVET, PEP/ square root of RR, and AT/ square root of RR--and were compared with pulmonary artery catheterization findings, i.e., systolic pulmonary arterial pressure (sPAP), log sPAP, mean PAP (mPAP), and log mPAP. Before sternotomy, PEP/AT, PEP/ square root of RR, and AT/ square root of RR showed significant correlation with all pulmonary artery catheterization values. AT/RVET showed correlation with all pulmonary artery values except log mPAP. PEP/AT showed the closest correlation with sPAP (r = 0.771) and log sPAP (r = 0.789). PEP/AT also showed close correlation with mPAP (r = 0.764) and log mPAP (r = 0.777). Significant agreement between sPAP and mPAP values calculated from a regression equation and values measured via pulmonary artery catheter was observed by plotting the differences against the mean values of the two measurements. We therefore conclude that noninvasive estimation of pulmonary arterial pressure is feasible via intraoperative TEE when sternotomy is not involved. (キーワード) Adult / Aged / Blood Pressure Determination / Echocardiography, Doppler, Pulsed / Echocardiography, Transesophageal / Female / Humans / Male / Middle Aged / Monitoring, Intraoperative / Pulmonary Artery / Regression Analysis (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000539-200106000-00002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11375806 ● Search Scopus @ Elsevier (PMID): 11375806 ● Search Scopus @ Elsevier (DOI): 10.1097/00000539-200106000-00002 (DOI: 10.1097/00000539-200106000-00002, PubMed: 11375806)
76.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Bronchospasm induced by cardiopulmonary bypass., Annals of Thoracic and Cardiovascular Surgery, Vol.7, No.1, 49-51, 2001. (キーワード) bronchospasm / cardiac surgery / cardiopulmonary bypass / complication (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11343567 ● CiNii @ 国立情報学研究所 (CRID): 1571417126218592640 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035259236 (PubMed: 11343567, CiNii: 1571417126218592640, Elsevier: Scopus)
77.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Intraoperative evaluation of pulmonary artery flow during the Fontan procedure by transesophageal Doppler echocardiography., Anesthesia & Analgesia, Vol.91, No.6, 1375-1380, 2000. (要約) After the Fontan procedure, pulmonary artery (PA) flow is maintained without right ventricular pump function. We evaluated intraoperative PA flow velocity patterns using transesophageal Doppler echocardiography (TEE) immediately after cardiopulmonary bypass (CPB) in patients during Fontan or hemi-Fontan procedures. We studied 10 patients with single-ventricle physiology (age range, 5 mo to 3 yr 1 mo). Anesthesia was induced and maintained with fentanyl. After induction of anesthesia, a pediatric TEE probe was inserted into the esophagus. All patients had surgical repair involving direct anastomosis of the right atrium to the PA. Immediately after completion of CPB, adequacy of the atriopulmonary anastomosis was assessed and PA flow velocity was recorded. In all patients, the atriopulmonary anastomosis was clearly defined using a single-plane TEE probe, and PA flow recording was completed successfully. Intraoperative PA flow velocities showed two distinct patterns. Biphasic forward flows with peak velocities during systole and diastole were observed in six patients. The remaining four patients showed forward flows with flow reversals. The four patients demonstrating flow reversals showed significantly reduced fractional shortening (26.5+/-2.1% vs. 35.5+/-6.3%) and larger pressure gradient between the right atrium and left atrium (10.8+/-1.3 mm Hg vs 8.0+/-0.9 mm Hg) when compared to those without reverse flow. Two patients with reverse flow required reoperation because of hypotension. Because PA flow is influenced by pulmonary vascular resistance and left ventricular function, TEE assessed intraoperative PA flow should be further evaluated as a useful predictor of surgical outcome after a Fontan procedure. (キーワード) Blood Pressure / Child, Preschool / Echocardiography, Transesophageal / Female / Fontan Procedure / Humans / Infant / Male / Monitoring, Intraoperative / Pulmonary Artery (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000539-200012000-00013 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11093983 ● Summary page in Scopus @ Elsevier: 2-s2.0-0033693365 (DOI: 10.1097/00000539-200012000-00013, PubMed: 11093983, Elsevier: Scopus)
78.	Kazuhiro Mori, Tetsuya Manabe, Masaki Nii, Yasunobu Hayabuchi, Yasuhiro Kuroda and Hiroshi Kitahata : Cyclic variation of integrated ultrasound backscatter in the left ventricle during the early neonatal period., American Heart Journal, Vol.140, No.3, 463-468, 2000. (要約) Significant changes in the contractility and histologic structure of the ventricular myocardium occur during the early neonatal period. Cyclic variation (CV) of ultrasonic integrated backscatter (IBS) reflects myocardial contractile performance. The aim of this study was to define normal values of and its serial changes in CV of IBS in the left ventricle of normal neonates. We recorded long-axis IBS images in 169 healthy neonates within 14 days after birth (mean 4.6 +/- 4.2 days) and in 84 infants and children (mean age 8.7 +/- 5.2 years). For each, we obtained CV of IBS in the interventricular septum (CV(IVS)) and the posterior wall (CV(PW)). In neonates, there was a significant linear correlation between CV and date after birth in measurements of both the interventricular septum and the posterior wall (r = 0.57 and 0. 60, respectively). In infants and children, there was no significant relation between age and CV(IVS) or CV(PW). In neonates >4 days after birth, the magnitude of CV(IVS) was not significantly different from that in infants or children. By contrast, the magnitude of CV(PW) was still significantly decreased in neonates >9 days after birth compared with that in infants and children (P <. 005). The ratio of CV(IVS) to CV(PW) (CV(IVS)/CV(PW)) was significantly higher in neonates than in infants and children (0.99 +/- 0.29 vs 0.80 +/- 0.22, P <.001). Both CV(IVS) and CV(PW) in neonates gradually increase after birth, indicating developmental maturation of the left ventricle. High values of CV(IVS)/CV(PW) might reflect the remnant of relatively high contractile performance in the right ventricle during fetal life. (キーワード) Adolescent / Child / Child, Preschool / Echocardiography / Female / Heart Ventricles / Humans / Infant, Newborn / Male / Myocardial Contraction / Reference Values / Ventricular Function / Ventricular Function, Left (出版サイトへのリンク) ● Publication site (DOI): 10.1067/mhj.2000.108515 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10966549 ● Search Scopus @ Elsevier (PMID): 10966549 ● Search Scopus @ Elsevier (DOI): 10.1067/mhj.2000.108515 (DOI: 10.1067/mhj.2000.108515, PubMed: 10966549)
79.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki, Akio Iseki and Shuzo Oshita : Transesophageal echocardiography for intraoperative management of the fenestrated Fontan procedure., Journal of Cardiothoracic and Vascular Anesthesia, Vol.14, No.4, 457-459, 2000. (キーワード) Echocardiography, Transesophageal / Female / Fontan Procedure / Heart Atria / Heart Septum / Humans / Infant / Intraoperative Complications / Tricuspid Atresia (出版サイトへのリンク) ● Publication site (DOI): 10.1053/jcan.2000.7961 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10972617 ● Summary page in Scopus @ Elsevier: 2-s2.0-0033870611 (DOI: 10.1053/jcan.2000.7961, PubMed: 10972617, Elsevier: Scopus)
80.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Transesophageal echocardiographic assessment of pulmonary arterial and venous flow during high-frequency jet ventilation., Journal of Clinical Anesthesia, Vol.12, No.4, 308-314, 2000. (要約) To evaluate high-frequency jet ventilation (HFJV) effects on pulmonary arterial and venous flow compared to those of intermittent positive-pressure ventilation (IPPV) by using pulsed Doppler transesophageal echocardiography. Prospective clinical study. University-affiliated hospital operating room.Patients: 13 ASA physical status I and II patients undergoing lower abdominal or lower extremity surgery. Patients had total IV anesthesia with propofol and fentanyl. After anesthesia induction, a transesophageal echocardiography probe was inserted into the esophagus. IPPV (TV, 8-10 mL/kg; respiratory rate, 10-12 cycles/min; I/E ratio, 1:2; FIO(2), 1.0) and HFJV (driving pressure, 0.5-0.6 kgf/cm(2); frequency,3 Hz; I/E ratio, 1:1; FIO(2), 1.0) were performed under hemodynamically stable conditions. Pulmonary-arterial-flow velocity, pulmonary-venous-flow velocity, left ventricular short-axis view, and airway-pressure curve were recorded simultaneously. Parameters measured were: hemodynamic variables, arterial blood gases, inspiratory airway pressure; [from pulmonary-arterial-flow velocity] pre-ejection period (PEP), acceleration time (AT), right ventricular ejection time (RVET), and their ratios (PEP/AT, AT/RVET); [from pulmonary-venous-flow velocity] time-velocity integral of the first systolic wave (S1), second systolic wave (S2), and diastolic wave (D), and systolic fraction (integral S1 + S2/S1+ S2 + D); [from M-mode] left-ventricular-end systolic volume, left-ventricular-end diastolic volume (LVEDV), stroke volume, cardiac output, and ejection fraction, using Teichholz's method. Peak inspiratory airway pressure during HFJV was significantly lower than that during IPPV. HFJV significantly decreased PEP/AT, correlating positively with pulmonary arterial pressure, and significantly increased AT and AT/RVET, correlating negatively with pulmonary arterial pressure. Systolic fraction, correlating negatively with left atrial pressure, increased significantly during HFJV, as did LVEDV, stroke volume, cardiac output, and ejection fraction. Our results suggest that, in comparison to IPPV, HFJV significantly decreases pulmonary arterial pressure and left atrial pressure, resulting in significant increases in cardiac output and ejection fraction in healthy anesthetized adults. (キーワード) Abdomen / Adult / Blood Gas Analysis / Echocardiography, Transesophageal / Female / High-Frequency Jet Ventilation / Humans / Intermittent Positive-Pressure Ventilation / Male / Middle Aged / Prospective Studies / Pulmonary Artery / Pulmonary Circulation / Pulmonary Veins (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S0952-8180(00)00166-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10960204 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034209588 (DOI: 10.1016/S0952-8180(00)00166-5, PubMed: 10960204, Elsevier: Scopus)
81.	Yasuo Tsutsumi, Shuzo Oshita, Hiroshi Kitahata, Yasuhiro Kuroda, Takashi Kawano and Yutaka Nakaya : Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology, Vol.92, No.4, 1154-1159, 2000. (要約) The adenosine triphosphate (ATP)-sensitive potassium (KATP) channels protect myocytes during ischemia and reperfusion. This study investigated the effects of thiamylal on the activities of KATP channels in isolated rat ventricular myocytes during simulated ischemia. Male Wistar rats were anesthetized with ether. Single, quiescent ventricular myocytes were dispersed enzymatically. Membrane currents were recorded using patch-clamp techniques. In the cell-attached configuration, KATP channel currents were assessed before and during activation of these channels by 2,4-dinitrophenol and after administration of 25, 50, and 100 mg/l thiamylal. The open probability was determined from current-amplitude histograms. In the inside-out configuration, the current-voltage relation was obtained before and after the application of thiamylal (50 mg/1). In the cell-attached configuration, 2,4-dinitrophenol caused frequent channel opening. 2,4-Dinitrophenol-induced channel activities were reduced significantly by glibenclamide, suggesting that the channels studied were KATP channels. Open probability of KATP channels was reduced by thiamylal in a concentration-dependent manner. KATP channels could be activated in the inside-out configuration because of the absence of ATP. Thiamylal inhibited KATP channel activity without changing the single-channel conductance. The results obtained in this study indicate that thiamylal inhibits KATP channel activities in cell-attached and inside-out patches, suggesting a direct action of this drug on these channels. (キーワード) 2,4-Dinitrophenol / ATP-Binding Cassette Transporters / Anesthetics, Intravenous / Animals / Cell Separation / Electrophysiology / Glyburide / Heart / Heart Ventricles / KATP Channels / Male / Membrane Potentials / Myocardial Ischemia / Myocardium / Patch-Clamp Techniques / Potassium Channels / Potassium Channels, Inwardly Rectifying / Rats / Rats, Wistar / Thiamylal / Uncoupling Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-200004000-00034 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10754636 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034033883 (DOI: 10.1097/00000542-200004000-00034, PubMed: 10754636, Elsevier: Scopus)
82.	Yoshiaki Hirose, Hideyuki Kimura, Hiroshi Kitahata, Shinji Kawahito and Shuzo Oshita : Nitric oxide does not play a major role in the regulation of systemic hemodynamic responses to acute normovolemic hemodilution., Acta Anaesthesiologica Scandinavica, Vol.44, No.1, 96-100, 2000. (要約) The mechanisms of cardiovascular changes following acute normovolemic hemodilution (ANH) have not been fully elucidated. We tested the hypothesis that inhibition of nitric oxide synthesis attenuates ANH-induced cardiovascular responses. We observed the effects of N(omega)-nitro-L-arginine methyl ester (L-NAME) pretreatment on ANH-induced cardiovascular responses and compared these effects with those elicited by phenylephrine (PHE). Twenty dogs anesthetized with isoflurane were divided into two groups: one group was pretreated with L-NAME and the other with PHE. Both groups were normovolemically hemodiluted using 6% hydroxyethyl starch to reduce the hemoglobin concentration to approximately 50% of the pretreatment value. Pretreatment with either L-NAME or PHE caused a significant increase in mean aortic blood pressure (MAP) and systemic vascular resistance (SVR) with a significant decrease in cardiac output (CO) and stroke volume (SV). However, no remarkable differences in these variables were seen between groups. In both groups ANH produced increases in heart rate, CO, SV, and maximal left ventricular dP/dt with a significant decrease in SVR. No significant differences in these variables were apparent after ANH except that MAP was decreased in the PHE group but not in the L-NAME group. Our results suggest that nitric oxide does not play a major role in mediation or modulation of the systemic vascular responses to ANH. (キーワード) Animals / Dogs / Enzyme Inhibitors / Female / Hemodilution / Hemodynamics / Male / NG-Nitroarginine Methyl Ester / Nitric Oxide (出版サイトへのリンク) ● Publication site (DOI): 10.1034/j.1399-6576.2000.440117.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10669279 ● Search Scopus @ Elsevier (PMID): 10669279 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1399-6576.2000.440117.x (DOI: 10.1034/j.1399-6576.2000.440117.x, PubMed: 10669279)
83.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Katsuya Tanaka and Shuzo Oshita : Recurrent laryngeal nerve palsy after cardiovascular surgery, --- Relationship to the placement of a transesophageal echocardiographic probe ---, Journal of Cardiothoracic and Vascular Anesthesia, Vol.13, No.5, 528-531, 1999. (要約) To examine the relationship between the incidence of recurrent laryngeal nerve palsy after cardiovascular surgery and the placement of a transesophageal echocardiographic probe. A prospective clinical study. A single-institutional study in a university hospital. One hundred sixteen patients undergoing cardiovascular surgery. All patients were assigned into one of two groups: 64 patients in whom transesophageal echocardiography (TEE) was performed and 52 patients in whom TEE was not performed during surgery. The incidence of recurrent laryngeal nerve palsy was examined and compared between the two groups. Five of 64 patients (7.8%) in whom TEE was monitored and 3 of 52 patients (5.8%) in whom TEE was not monitored were diagnosed with recurrent laryngeal nerve palsy postoperatively. There was no statistically significant difference between the incidence of recurrent laryngeal nerve palsy in patients with intraoperative TEE monitoring, and patients without it. The durations of surgery, anesthesia, and cardiopulmonary bypass were significantly longer in patients with nerve palsy than those without it. These results suggest that placement of the transesophageal echocardiographic probe is not responsible for postoperative recurrent laryngeal nerve palsy. It seems likely that surgical manipulation itself and the durations of surgery, cardiopulmonary bypass, and tracheal intubation are related to the incidence of laryngeal nerve palsy. (キーワード) Cardiopulmonary Bypass / Cardiovascular Surgical Procedures / Echocardiography, Transesophageal / Female / Humans / Intubation, Intratracheal / Male / Middle Aged / Monitoring, Intraoperative / Prospective Studies / Vocal Cord Paralysis (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S1053-0770(99)90002-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10527219 ● Search Scopus @ Elsevier (PMID): 10527219 ● Search Scopus @ Elsevier (DOI): 10.1016/S1053-0770(99)90002-2 (DOI: 10.1016/S1053-0770(99)90002-2, PubMed: 10527219)
84.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Katsuya Tanaka and Shuzo Oshita : Autotransfusion performed on a patient with cis AB blood group., British Journal of Anaesthesia, Vol.83, No.3, 491-492, 1999. (要約) Cis AB blood group is a rare variant of the AB blood group resulting from inheritance of both A and B genes on one chromosome. It may lead to misclassification in ABO grouping and clinical misdiagnosis as a result of its divergence from the laws of Landsteiner and Mendel. We encountered a case of cis AB blood group, and we found that autotransfusion was useful during surgery in this patient with a rare blood group. (キーワード) ABO Blood-Group System / Blood Transfusion, Autologous / Female / Humans / Hysterectomy / Intraoperative Care / Middle Aged (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10655930 ● Search Scopus @ Elsevier (PMID): 10655930 (PubMed: 10655930)
85.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Pulmonary hemodynamics, --- Intraoperative assessment with transesophageal Doppler echocardiography ---, Critical Care International, Vol.9, No.4, 10-12, 1999.
86.	Hiroshi Kitahata, Katsuya Tanaka, Hideyuki Kimura, Shinji Kawahito and Shuzo Oshita : The feasibility of gastrothoracic ventricular pacing during transesophageal echocardiography., Anesthesia & Analgesia, Vol.89, No.1, 21-25, 1999. (要約) We evaluated whether ventricular pacing is possible using pacing electrodes attached to a transesophageal echocardiography (TEE) probe in 20 patients undergoing elective cardiovascular surgery. A bipolar pacing lead was fixed with silicone adhesive anteriorly to the TEE probe with the distal electrode 25 mm from the TEE probe tip. The TEE probe was positioned to obtain a transgastric short-axis view of the left ventricle. The distal or proximal electrode on the TEE probe was the cathode; the chest electrode placed at the V5 lead position was the anode. Gastrothoracic ventricular pacing (GVP) was performed at 100 bpm at 30- or 50-ms pulse duration. Transgastric ventricular pacing (TVP) was also attempted using both TEE probe electrodes alternately as cathode/anode. Maximal generator output was 32 mA. GVP with the distal electrode as cathode was successful in 75% and 80% of patients at 30- and 50-ms pulse durations and 23.3+/-5.8 mA and 22.6+/-5.8 mA threshold currents, respectively. However, success rates (20% and 25%, respectively) were significantly lower with the proximal electrode as cathode using the same pulse durations and 14.4+/-5.3 mA and 16.7+/-6.8 mA threshold currents. The TVP success rate was significantly lower than that for GVP. With optimization, this system could become an available technique for intraoperative emergency ventricular pacing. Using an endocardial pacing lead attached to a transesophageal echocardiography probe, gastrothoracic ventricular pacing can be performed successfully without complications in 75%-80% of patients undergoing cardiovascular surgery. (キーワード) Adult / Aged / Cardiac Pacing, Artificial / Echocardiography, Transesophageal / Female / Humans / Male / Middle Aged (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000539-199907000-00004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10389772 ● Summary page in Scopus @ Elsevier: 2-s2.0-0032975999 (DOI: 10.1097/00000539-199907000-00004, PubMed: 10389772, Elsevier: Scopus)
87.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Yukiko Ikeuchi, Hideyuki Kimura, Yoshiaki Hirose and Shuzo Oshita : Intraoperative management of a pediatric patient undergoing cardiac tumor resection with the aid of transesophageal and epicardial echocardiography., Anesthesia & Analgesia, Vol.88, No.5, 1048-1050, 1999. (キーワード) Child / Echocardiography / Echocardiography, Transesophageal / Female / Heart Neoplasms / Humans (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000539-199905000-00014 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10320166 ● Search Scopus @ Elsevier (PMID): 10320166 ● Search Scopus @ Elsevier (DOI): 10.1097/00000539-199905000-00014 (DOI: 10.1097/00000539-199905000-00014, PubMed: 10320166)
88.	Hiroshi Kitahata, Shinji Kawahito, Junpei Nozaki, Hideyuki Kimura, Katsuya Tanaka, Tetsuya Kitagawa and Shuzo Oshita : effects of sevoflurane on regional myocardial blood flow distribution, --- Quantification with myocardial contrast echocardiography ---, Anesthesiology, Vol.90, No.5, 1436-1445, 1999. (要約) Using myocardial contrast echocardiography, the authors tried to determine whether sevoflurane causes myocardial blood maldistribution in humans and dogs. In animal experiments, 15 mongrel dogs were organized into dipyridamole (n = 6) and sevoflurane (n = 9) groups. Sonicated albumin was infused into the left main coronary artery. The peak gray level corrected for background was analyzed at the following intervals: (1) at baseline, (2) after stenosis of the left circumflex coronary artery (blood flow reduced by 40%), (3) after administration of dipyridamole (1 mg/kg given intravenously) or sevoflurane (1 minimum alveolar concentration) during stenosis, and (4) after phenylephrine during stenosis and administration of dipyridamole or sevoflurane. In human studies, nine patients undergoing coronary artery bypass grafting were studied. During partial extracorporeal circulation, the peak gray level was analyzed before and 20 min after sevoflurane (1 minimum alveolar concentration). In animal experiments, dipyridamole decreased significantly the inner:outer ratio of the peak gray level in the ischemic area and the ischemic:normal ratio of the peak gray level. After arterial pressure was restored with phenylephrine, neither the inner:outer ratio nor the ischemic:normal ratio improved. In contrast, after sevoflurane administration, the inner:outer ratio and the ischemic:normal ratio remained unchanged, but these increased with phenylephrine. In human studies, sevoflurane did not change the inner:outer ratio in the area supplied by the most stenotic coronary artery. These results suggest that dipyridamole, a potent coronary vasodilator, produces maldistribution of coronary blood flow in our dog models, whereas sevoflurane does not do this in animal or human studies. (キーワード) Aged / Anesthetics, Inhalation / Animals / Coronary Circulation / Dipyridamole / Dogs / Echocardiography / Female / Humans / Male / Methyl Ethers / Middle Aged (出版サイトへのリンク) ● Publication site (DOI): 10.1097/00000542-199905000-00029 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10319793 ● Summary page in Scopus @ Elsevier: 2-s2.0-0032912972 (DOI: 10.1097/00000542-199905000-00029, PubMed: 10319793, Elsevier: Scopus)
89.	Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Hideyuki Kimura and Shuzo Oshita : Simultaneous transesophageal echocardiography and atrial pacing for intraoperative management of mitral regurgitation., Anesthesiology, Vol.90, No.1, 305-308, 1999.
90.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Katsuya Tanaka, Yoko Sakai, Yoshiaki Hirose and Shuzo Oshita : Anaesthetic management of a patient with Williams syndrome undergoing aortoplasty for supravalvular aortic stenosis., Canadian Journal of Anaesthesia, Vol.45, No.12, 1203-1206, 1998. (要約) A case of a patient associated with Williams syndrome undergoing aortoplasty for supravalvular aortic stenosis is presented. Williams syndrome is a rare disease associated with a characteristic facies, supravalvular aortic stenosis, and mental retardation. A 15-yr-old girl with Williams syndrome underwent aortoplasty for supravalvular aortic stenosis. Anaesthesia was induced with fentanyl and thiamylal, and maintained with nitrous oxide, oxygen, sevoflurane, and continuous intravenous infusion of fentanyl. Supravalvular aortic stenosis was evaluated using a multiplane transesophageal echocardiography (TEE) probe before and after repair. Multiplane TEE was found to be very useful for anaesthetic management in a patient with Williams syndrome undergoing aortoplasty for supravalvular aortic stenosis. (キーワード) Adolescent / Anesthesia, General / Anesthetics, Inhalation / Anesthetics, Intravenous / Aortic Valve Stenosis / Echocardiography, Doppler, Color / Echocardiography, Transesophageal / Female / Fentanyl / Humans / Methyl Ethers / Nitrous Oxide / Oxygen / Thiamylal / Williams Syndrome (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF03012465 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10051941 ● Search Scopus @ Elsevier (PMID): 10051941 ● Search Scopus @ Elsevier (DOI): 10.1007/BF03012465 (DOI: 10.1007/BF03012465, PubMed: 10051941)
91.	Katsuya Tanaka, Shuzo Oshita, Hiroshi Kitahata, Hideyuki Kimura, Shinji Kawahito, Y-C Park and Takeshi Sakabe : Effects of nicardipine on ventriculo-arterial coupling in humans., British Journal of Anaesthesia, Vol.81, No.2, 180-185, 1998. (要約) The ratio of effective arterial elastance (Ea) to left ventricular elastance (Ees) is an indicator of the coupling between ventricular properties and arterial load properties. Another criterion for the coupling between an energy source and its load is the principle of economical fuel consumption, or mechanical efficiency, which is defined as the ratio of stroke work (SW) to myocardial oxygen consumption per beat (MVO2). It has been revealed that SW of ventricular contraction is maximized when Ea/Ees = 1, while mechanical efficiency is maximized when Ea/Ees = 0.5. The purpose of the present study was to investigate the ventriculo-arterial coupling during hypertension, and the effects of nicardipine on this relationship in surgical patients using Ea/Ees and SW/MVO2 as indicators. Anaesthesia was maintained with isoflurane, nitrous oxide, and fentanyl. Radial artery pressure was displayed on a polygraph, and left ventricular end-systolic and end-diastolic volumes were determined by use of transoesophageal echocardiography. Ees was calculated as MAP/(ESVI-4), where MAP is mean arterial pressure and ESVI is end-systolic volume index. Ea was calculated as the ratio of MAP to stroke volume index (SVI). Stroke work index (SWI) was calculated as the product of MAP and SVI. MVO2 was assessed by estimating the ventricular pressure-volume area index (PVAI), which is expressed as the sum of SWI and the end-systolic potential energy index. Before (baseline), and 3, 10, 20, and 30 min after i.v. nicardipine (30 micrograms kg-1), Ea/Ees and SWI/PVAI were determined in 14 surgical patients with intraoperative hypertension. Before nicardipine (during hypertension), Ea was almost equal to Ees, whereas Ea/Ees was significantly reduced to about 0.5-0.6 at 3, 10, and 20 min after nicardipine. SWI/PVAI was maximized and significantly greater than the baseline value at 3 min after nicardipine. These results suggest that, during hypertension, ventricular and arterial properties were so matched as to maximize SW at the expense of the work efficiency, whereas mechanical efficiency of ventricular contraction was maximized after nicardipine. (キーワード) Adult / Anesthetics, Inhalation / Antihypertensive Agents / Blood Pressure / Dose-Response Relationship, Drug / Elasticity / Feedback / Female / Hemodynamics / Humans / Hypertension / Isoflurane / Male / Middle Aged / Nicardipine / Pulmonary Artery / Stroke Volume / Ventricular Function, Left (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9813519 ● Search Scopus @ Elsevier (PMID): 9813519 (PubMed: 9813519)
92.	Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Arata Iuchi, Susumu Ito, Takaki Hori, Tetsuya Kitagawa, Itsuo Kato, Hiroshi Kitahata and Shuzo Oshita : Role of left atrial appendage in left atrial reservoir function as evaluated by left atrial appendage clamping during cardiac surgery., The American Journal of Cardiology, Vol.81, No.2, 327-332, 1998.
93.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura and Arifumi Kohyama : Intraoperative contrast transesophageal echocardiography using Albunex., Journal of Anesthesia, Vol.10, No.4, 233-238, 1996. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF02483387 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1007/BF02483387 (DOI: 10.1007/BF02483387)
94.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Arifumi Kohyama and Takao Saito : A case of pulmonary arteriovenous fistula in which venous air embolism during cesarean section may have caused postoperative subendocardial infarction., Journal of Anesthesia, Vol.9, No.4, 370-373, 1995. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF02479957 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23839892 ● Search Scopus @ Elsevier (PMID): 23839892 ● Search Scopus @ Elsevier (DOI): 10.1007/BF02479957 (DOI: 10.1007/BF02479957, PubMed: 23839892)
95.	Arifumi Kohyama, Ritsuko Goh, Keiichi Mori, Satoshi Yasumoto, Hideyuki Kimura and Hiroshi Kitahata : Effect of Gabexate mesilate on postoperative blood loss in cardiovascular surgery using cardiopulmonary bypass., Journal of Anesthesia, Vol.8, No.3, 368-372, 1994. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF02514671 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23568133 ● Search Scopus @ Elsevier (PMID): 23568133 ● Search Scopus @ Elsevier (DOI): 10.1007/BF02514671 (DOI: 10.1007/BF02514671, PubMed: 23568133)
96.	Hiroshi Kitahata, Michihisa Kato, Kazumasa Orihashi, Paul L. Goldiner and Yasu Oka : Left ventricular diastolic filling during coronary artery bypass surgery in patients with diabetes mellitus and/or hypertension., Journal of Anesthesia, Vol.8, No.2, 137-142, 1994. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF02514700 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1007/BF02514700 (DOI: 10.1007/BF02514700)
97.	Kazuo Ushijima, Yasu Oka, Paul Weinberg, Hiroshi Kitahata, Edward L. Yellin and Paul L. Goldiner : Hemodynamic effects of high-frequency ventilation in dogs with acute right coronary arterial ligation and pulmonary arterial banding., Journal of Anesthesia, Vol.4, No.3, 232-241, 1990. (要約) The hemodynamic effects of high-frequency jet ventilation (HFJV), synchronized with diastole, and intermittent positive-pressure ventilation (IPPV) were studied in 10 dogs with acute right-sided myocardial ischemia and elevated right ventricular pressure. Myocardial ischemia was produced by ligation of the proximal right coronary artery (RCA), then the right ventricular pressure was elevated to facilitate the ischemia by banding the main pulmonary artery. Before and 1, 2, 3, and 5 hr after the RCA ligation, cardiorespiratory variables for each ventilatory mode and creatine phosphokinase MB isoenzyme (CPK-MB) were measured. During HFJV compared with IPPV: there were significant increases in stroke index and left ventricular stroke work index at all ischemic periods, and decreases in peak and mean airway pressures and pulmonary vascular resistance at all ischemic periods, and in the product of systolic right ventricular pressure and heart rate at 2 hr, 3 hr, and 5 hr. The difference in mean airway pressure between IPPV and HFJV correlated significantly with those in cardiac index and stroke index (r = 0.575 and 0.779, respectively). CPK-MB was significantly greater at 3 hr and 5 hr than that before RCA ligation. These findings suggest that HFJV synchronized with diastole offers hemodynamic advantages over IPPV to ischemic right ventricle with constricted pulmonary artery, mainly due to lowering the mean airway pressure. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s0054000040232 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15235979 ● Search Scopus @ Elsevier (PMID): 15235979 ● Search Scopus @ Elsevier (DOI): 10.1007/s0054000040232 (DOI: 10.1007/s0054000040232, PubMed: 15235979)
98.	Yasu Oka, Hiroshi Kitahata, C Komer, Edward L. Yellin and Paul L. Goldiner : Left ventricular diastolic function using transesophageal Color Flow Doppler., American Journal of Cardiac Imaging, Vol.4, No.2, 125-129, 1990.
99.	Yasu Oka, YW Hong, T Tamura, Hiroshi Kitahata, Kazumasa Orihashi, Edward L. Yellin and Paul L. Goldiner : Quantitative analysis of transmitral flow and a preliminary study of pulmonary vein flow., International Journal of Cardiac Imaging, Vol.4, No.1, 19-22, 1989.
100.	Hiroshi Kitahata, Satoshi Yasumoto, Hideyuki Kimura, Akio Kondo, Suguru Watanabe, Arifumi Kohyama and Takao Saito : Postoperative cardiac complications in patients with a history of myocardial infarction., The Tokushima Journal of Experimental Medicine, Vol.31, No.3-4, 61-66, 1984.

学術論文(紀要・その他):

1.	川人伸次, 高石和美, 曽我朋宏, 北畑洋 : 血管新生に及ぼす麻酔薬と周術期管理法の影響, BIO Clinica, Vol.33, No.1, 1178-1182, 2016年.
2.	Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Arata Iuchi, Takaki Hori, Tetsuya Kitagawa, Itsuo Kato, Hiroshi Kitahata, Shuzo Oshita and Susumu Ito : Roles of left atrial appendage for left atrial hemodynamics by left atrial appendage clamping during cardiac surgery., Circulation, Vol.94, I-252, 1996.

学術レター:

1.	川人伸次, 井関明生, 河野崇, 髙田香, 北畑洋, 大下修造 : 徳島大学病院における手術前日・当日入院システムの紹介, 日本小児麻酔学会誌, Vol.13, 171-176, 2007年.

総説・解説:

1.	高石和美, 藤原茂樹, 江口覚, 大塚良, 赤澤友基, 北村尚正, 上田(山口) 公子, 中川弘, 可児耕一, 青田桂子, 桃田幸弘, 山村佳子, 工藤景子, 大江剛, 玉谷哲也, 宮本洋二, 東雅之, 岩本勉, 北畑洋 : 当院における全身麻酔下歯科治療について -障害をもつ方へ安全な歯科治療の提供-, Journal of Oral Health and Biosciences, Vol.31, No.1, 62-67, 2018年7月. (要約) We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs. (キーワード) 全身麻酔 / 障害者 / 日帰り全身麻酔 / 歯科治療 (徳島大学機関リポジトリ) ● Metadata: 111940 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.31.1_62 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390845712973457920 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_62 (徳島大学機関リポジトリ: 111940, DOI: 10.20738/johb.31.1_62, CiNii: 1390845712973457920)
2.	川人伸次, 曽我朋宏, 箕田直治, 堤保夫, 田中克哉, 高石和美, 北畑洋, 木下浩之 : 2.カリウムチャネルと循環, --- 第37回総会シンポジウム2「神経調節による循環制御」 ---, 循環制御, Vol.37, No.3, 181-184, 2016年12月.
3.	Yasushi Mio, Shoichi Uezono and Hiroshi Kitahata : Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science., Current Pharmaceutical Design, Vol.20, No.36, 5673-5680, Feb. 2014. (要約) Anesthetic pre- and postconditioning pharmacologically reduce ischemia/reperfusion injury. Mitochondria play a central role in these myocardial protective salvage effects. In the preconditioning, low levels of reactive oxygen species, which are produced by anesthetics in the mitochondria, act as a trigger to prevent cardiomyocytes death and modify intracellular signaling mechanisms. In the postconditioning, decreased mitochondrial matrix pH, which was caused by anesthetics, triggers the onset of a rapid protective effect. The mitochondrial membranes have several ion channels that act as major determining factors of cellular life and death under pathophysiological conditions. In these channels, the mitochondrial adenosine triphosphate-sensitive K+ channels, the mitochondrial Ca2+-activated K+ channels and mitochondrial permeability transition pores play critical roles in cardioprotection against ischemia/reperfusion injury. Mitochondrial permeability transition pores are end effectors, which contribute to myocardial preconditioning and postconditioning. Activation of intracellular signaling and acidification of mitochondrial matrix pH prevent the mitochondrial permeability transition pore opening, and therefore, preserve the mitochondrial function to supply adenosine triphosphate, resulting in myocardial protection due to the maintenance of intracellular homeostasis. (出版サイトへのリンク) ● Publication site (DOI): 10.2174/1381612820666140204110101 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24502577 ● Search Scopus @ Elsevier (PMID): 24502577 ● Search Scopus @ Elsevier (DOI): 10.2174/1381612820666140204110101 (DOI: 10.2174/1381612820666140204110101, PubMed: 24502577)
4.	川人伸次, 北畑洋 : 特集モニタリングを検証する, --- 「循環系:心拍出量モニタリングを中心に」 ---, 麻酔, Vol.61, No.1, 25-34, 2012年1月. (キーワード) 肺動脈カテーテル / 経食道心エコー法 / 非心臓手術 / 心拍出量 / 低侵襲 / モニタリング / less invasive circulatory monitoring / pulmonary artery catheter / transesophageal echocardiography / pressure pulse waveform analysis / cardiac output (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22338857 ● CiNii @ 国立情報学研究所 (CRID): 1520009409183616896 ● Summary page in Scopus @ Elsevier: 2-s2.0-84856135637 (PubMed: 22338857, CiNii: 1520009409183616896, Elsevier: Scopus)
5.	北畑洋 : 麻酔と周術期心筋虚血, 四国歯学会雑誌, Vol.23, No.2, 71-83, 2011年1月. (徳島大学機関リポジトリ) ● Metadata: 109801 (徳島大学機関リポジトリ: 109801)
6.	Shinji Kawahito, Hiroshi Kitahata, Tetsuya Kitagawa and Shuzo Oshita : Intensive insulin therapy during cardiovascular surgery., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 191-204, Aug. 2010. (要約) Recent evidence in the fields of surgery, emergency and critical care medicine indicates that strict glycemic control results in lower mortality. Hyperglycemia occurs frequently in patients with and without diabetes during cardiovascular surgery, especially during cardiopulmonary bypass. However, strict glucose control is difficult to achieve during cardiovascular procedures. To establish effective intensive insulin therapy during cardiovascular surgery, we conduct continuous blood glucose monitoring and employ automatic control by using an artificial endocrine pancreas (the STG-22, Nikkiso, Tokyo, Japan). In this review, we will outline the present status and problems of conventional glycemic control for perioperative cardiovascular surgery and introduce the new perioperative blood glucose management method that we are testing now. We will also discuss the importance of perioperative glycemic control for cardiovascular surgery as well as future prospects. (キーワード) Blood Glucose / Cardiopulmonary Bypass / Cardiovascular Surgical Procedures / Diabetes Complications / Humans / Hyperglycemia / Hypoglycemic Agents / インスリン (insulin) / Intensive Care / 日本 (Japan) / Monitoring, Intraoperative / Pancreas, Artificial / Randomized Controlled Trials as Topic (徳島大学機関リポジトリ) ● Metadata: 70456 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.57.191 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847518 ● Search Scopus @ Elsevier (PMID): 20847518 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.191 (徳島大学機関リポジトリ: 70456, DOI: 10.2152/jmi.57.191, PubMed: 20847518)
7.	北畑洋 : VIII 循環作動薬アルプロスタジル, 麻酔薬および麻酔関連薬使用ガイドライン第3版, 198-200, 2009年12月.
8.	Shinji Kawahito, Hiroshi Kitahata and Shuzo Oshita : Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress., World Journal of Gastroenterology : WJG, Vol.15, No.33, 4137-4142, Nov. 2009. (要約) Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic superphysiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of beta-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period. (キーワード) Diabetes Complications / グルコース (glucose) / 生体恒常性 (homeostasis) / Humans / Hyperglycemia / インスリン (insulin) / インスリン抵抗性 (insulin resistance) / 酸化ストレス (oxidative stress) / Surgical Wound Infection (出版サイトへのリンク) ● Publication site (DOI): 10.3748/wjg.15.4137 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19725147 ● Search Scopus @ Elsevier (PMID): 19725147 ● Search Scopus @ Elsevier (DOI): 10.3748/wjg.15.4137 (DOI: 10.3748/wjg.15.4137, PubMed: 19725147)
9.	北畑洋, 川人伸次 : 2. 虚血性心疾患 TEEセミナー「私のルーチン」, Cardiovascular Anesthesia, Vol.13, No.1, 107-113, 2009年5月.
10.	川人伸次, 北畑洋 : 心エコー・ドプラ法の新技術, --- -後方散乱エコーとストレイン/ストレインレート- ---, 日本臨床麻酔学会誌, Vol.28, No.4, 643-651, 2008年7月.
11.	北畑洋 : 生体機能検査による術中モニタリング (5), --- 経食道心エコーによる術中モニタリング ---, 臨床病理, Vol.56, No.6, 508-516, 2008年6月. (要約) Transesophageal echocardiography (TEE) has become a routine monitor in the operating room for cardiac surgery because it provides instantaneous and continuous assessment of cardiac function and anatomy. TEE aids intraoperative management and improves outcome in patients undergoing cardiac valve repairs, complex congenital heart corrections, and high-risk patients undergoing coronary artery bypass graft surgery. Especially in mitral valve repair surgery, it is mandatory to evaluate the results of the surgical procedure after cardiopulmonary bypass during surgery. Multiple investigations have also documented the improved sensitivity of TEE for the detection of myocardial ischemia compared with ECG or pulmonary capillary wedge pressure measurements. Intraoperative TEE is, however, not without risks, so emerging evidence demonstrating the utility of TEE as a diagnostic monitor or to alter the management of patients is required, especially in non-cardiac surgery. TEE is less frequently used in non-cardiac surgery; however, the emergent use of intraoperative or perioperative TEE to determine the cause of an acute, persistent, and life-threatening hemodynamic abnormality is well indicated. A task force of the American Society of Anesthesiologists and the Society of Cardiovascular Anesthesiologists developed guidelines for the appropriate use of TEE, which were evidence-based and focused on the effectiveness of perioperative TEE in improving clinical outcomes. Compliance with the guidelines for basic intraoperative TEE resulted in a marked improvement in intraoperative TEE practice. Technical progress of echocardiographic equipment and the TEE probe will increase the application of intraoperative and perioperative TEE in the future. (キーワード) Cardiovascular Surgical Procedures / Echocardiography, Transesophageal / Humans / Monitoring, Intraoperative (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18646636 ● Search Scopus @ Elsevier (PMID): 18646636 (PubMed: 18646636)
12.	川人伸次, 北畑洋 : 小児麻酔における経食道心エコーの功罪, 日本臨床麻酔学会誌, Vol.27, No.5, 528-538, 2007年9月.
13.	北畑洋 : 実践麻酔シリーズ, --- 経食道心エコー:重要ポイントはこれだ ---, Anesthesia Network, Vol.4, No.3, 22-26, 2000年8月.
14.	大下修造, 堤保夫, 北畑洋 : 手術中の不整脈 -原因，診断，治療-, 麻酔, Vol.48, S208-S217, 1999年12月.
15.	北畑洋 : 特集「吸入麻酔薬と冠循環」, --- 吸入麻酔薬とcoronary steal現象 ---, Anesthesia Network, Vol.3, No.4, 3-6, 1999年10月.
16.	北畑洋 : 経食道心エコーの術中応用-最近の話題, --- 麻酔中のモニタリング-最近の話題 ---, 日本臨床麻酔学会誌, Vol.19, No.4, 244-247, 1999年5月.
17.	郷律子, 北畑洋 : 吸入麻酔薬とcoronary steal -最近の動向-, 循環制御, Vol.13, No.1, 39-45, 1992年3月.
18.	北畑洋, 丘ヤス : 心臓血管系の超音波ドプラー法 -麻酔科領域(Ⅱ)-, --- 経食道カラードプラ心エコーの術中応用 ---, 循環制御, Vol.11, No.1, 31-35, 1990年3月.
19.	Yasu Oka, Hiroshi Kitahata and Paul L. Goldiner : Applications of transesophageal two-dimensional color Doppler echocardiography in cardiac anesthesia, --- Present and future ---, Medical Review, Vol.28, 13-19, May 1989.

国際会議:

1.	Zhong Yirun, Li Yang, Pu Taofei, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata and Jin-Ping Ao : GaN Schottky Barrier Diodes for Microwave Rectification with Enhanced Cut-off Frequency, The 2020 International Conference on Solid State Devices and Materials (SSDM 2020), Sep. 2020.
2.	Naoji Mita, Shinji Kawahito, Tomohiro Soga, Shusuke Yagi, Kazumi Takaishi and Hiroshi Kitahata : Can strict blood glucose control by an artificial pancreas during hepatectomy improve patient outcomes?, The 8th Meeting of the International Federation for Artificial Organs, Osaka, Nov. 2019.
3.	Kazumi Takaishi, Tomohiro Aoyama, Shigeki Fujiwara Joseph Luke, Ryo Otsuka, Satoru Eguchi, Yasuo Tsutsumi, Shinji Kawahito, Hiroyuki Kinoshita and Hiroshi Kitahata : Pleth Variability Index Predicts Hemodynamic Derangements In Patients Undergoing Oral Surgery, The Anesthesiology 2019 Annual Meeting, Orando USA, Oct. 2019.
4.	Taofei Pu, Xiao Wang, Qian Huang, Xiaobo Li, Yuyu Bu, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata and Jin-Ping Ao : Normally-off AIGaN/GaN heterojunction field-effect transistors, 6th International Symposium on 2019 Single Crystal Diamond and Electronics, Xi'an, Jun. 2019.
5.	Nakao Shunsuke, Shigeki Fujiwara Joseph Luke, Yang Li, Aoki Kazuki, Hiroshi Kitahata and Jin-Ping Ao : Microwave wireless power transfer system for small medical equipment, 6th International Symposium on 2019 Single Crystal Diamond and Electronics, Xi'an, Jun. 2019.
6.	Yang Li, Shunsuke Nakao, Shigeki Fujiwara Joseph Luke, Kazuki Aoki, Hiroshi Kitahata and Jin-Ping Ao : High resolution via-hole etching technique for silicon carbon substrate, 6th International Symposium on 2019 Single Crystal Diamond and Electronics, Xi'an, Jun. 2019.
7.	Shigeki Fujiwara Joseph Luke, Nakao Shusuke, Yang Li, Jin-Ping Ao, Kazumi Takaishi and Hiroshi Kitahata : Fabrication and clinical application of a wireless-power-transmission-type medical device, Euroanaesthesia 2019, Wien, Jun. 2019.
8.	Xiaobo Li, Taofei Pu, Taiki Hoshi, Tian Xie, Liuan Li, Xianjie Li, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata and Jin-Ping Ao : Nickel Nitride Gate AlGaN/GaN HFETs with Low Gate Leakage Current, 2018 International Workshop on Nitride Semiconductors, Kanazawa, Nov. 2018.
9.	Jin-Ping Ao, Xiaobo Li, Taofei Pu, Taiki Hoshi, Tian Xie, Liuan Li, Xianjie Li, Shigeki Fujiwara Joseph Luke and Hiroshi Kitahata : Gallium Nitride RF Schottky Barrier Diodes for Microwave Wireless Power Transmission, 2018 International Forum on Wide Bandgap Semiconductors, Shenzhen, Oct. 2018.
10.	Xiaobo Li, Taofei Pu, Taiki Hoshi, Tian Xie, Liuan Li, Xianjie Li, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata and Jin-Ping Ao : Synthesis of nickel nitride electrodes for application on gallium nitride Schottky contact, 14th IUPAC International Conference on Novel Materials and their Synthesis, Guangzhou, Oct. 2018.
11.	Shiho Satomi, Kazumi Takaishi, Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka and Kinoshita Hiroyuki : The role of F-actin constitution in oxidative stress caused by high glucose in the human artery, American Society of Anesthesiologists Annual meeting 2018, San Francisco, Oct. 2018.
12.	Shigeki Fujiwara Joseph Luke, K Tachihara, S Mori, 大塚良, T Yamamoto, Satoru Eguchi, Kazumi Takaishi, I Toyoguchi, Jin-Ping Ao and Hiroshi Kitahata : Influence of PTS stopcock status on the natural frequency of blood pressure‒transducer kits, Joint Conference of IFDAS2018-FADAS2018-JDSA46, Nara, Oct. 2018.
13.	山本剛士, Kazumi Takaishi, 大塚良, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Tomohiro Soga, Shinji Kawahito and Hiroshi Kitahata : Three‒dimensional computed tomography and nasopharyngoscopy for nasotracheal intubation after pharyngeal flap construction, Joint Conference of IFDAS2018-FADAS2018-JDSA46, Nara, Oct. 2018.
14.	Kazumi Takaishi, s Satomi, Naoji Mita, T Yamamoto, 大塚良, Satoru Eguchi, Shigeki Fujiwara Joseph Luke, Shinji Kawahito, H Kinoshita and Hiroshi Kitahata : Rapamycin becomes the sevoflurane vasodilator effect apparent in the rat artery, Joint Conference of IFDAS2018-FADAS2018-JDSA46, Nara, Oct. 2018.
15.	Satomi Shiho, Kazumi Takaishi, Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka and Kinoshita Hiroyuki : Roles of clinical sevoflurane doses as both the protein kinase C activator and NADPH oxidase inhibitor upon thromboxane A2 application in the rat arteries., American Society of Anesthesiologists 2017 Annual Meeting, Oct. 2017.
16.	Shiho Satomi, Shinji Kawahito, Tomohiro Soga, Naoji Mita, Eisuke Hamaguchi, Kazumi Takaishi, Hiroshi Kitahata, Yasuo Tsutsumi and Katsuya Tanaka : Accuracy and Reliability of Continuous Blood Glucose Monitoring During Pediatric Cardiopulmonary Bypass, The Annual Meeting of the American Society of Anesthesiologists, Chicago, Oct. 2016.
17.	Naoji Mita, Shinji Kawahito, Tomohiro Soga, Katsuya Tanaka, Kazumi Takaishi and Hiroshi Kitahata : Blood glucose control by artificial endocrine pancreas during hepatectomy prevents postoperative acute kidney injury., The Annual Meeting of the American Society of Anesthesiologists, San Diego, Oct. 2015.
18.	Hiroshi Kitahata, Yasuo M. Tsutsumi, Tomohiro Aoyama, Kazumi Takaishi, Shinji Kawahito and Katsuya Tanaka : Role of sirtuins in cardioprotection by ischemic and anesthetic preconditioning., Euroanaesthesia 2015, The European Anaesthesiology Congress, Berlin, Jun. 2015.
19.	Kazumi Takaishi, Tomohiro Soga, Shinji Kawahito, Ryo Otsuka, Yasuo M. Tsutsumi and Hiroshi Kitahata : Effects of beta-3 adrenergic stimulation on nitric oxide production in myocardial cells of neonatal rats., Euroanaesthesia 2015, The European Anaesthesiology Congress, Berlin, May 2015.
20.	Kazumi Takaishi, Shinji Kawahito, Naoji Mita, Tomohiro Aoyama, R Otsuka and Hiroshi Kitahata : The effects of intravenous anesthetics on cell migration using cultured human umbilical vein endothelial cells, IARS 2015 Annual Meeting and International Science Symposium, Honolulu, Mar. 2015.
21.	Naoji Mita, Shinji Kawahito, T Kawahara, K Kume, Sachiyo Higashijima, Yoko Sakai, Tosiko Katayama, Kazumi Takaishi and Hiroshi Kitahata : Usefulness of continuous blood glucose monitoring and control for patients undergoing total pancreatectomy., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2014.
22.	Naoji Mita, Shinji Kawahito, T Kawahara, Katsuyoshi Kume, Sachiyo Higashijima, Yoko Sakai, Tosiko Katayama, Kazumi Takaishi and Hiroshi Kitahata : Is the continuous interstitial subcutaneous fluid glucose monitoring system useful for intraoperative glucose management?, The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2014.
23.	Kazumi Takaishi, Shinji Kawahito, Aoyama Tomohiro, Otsuka Ryo, Naoji Mita, Satoru Eguchi, Shigemasa Tomioka and Hiroshi Kitahata : The effects of ketamine on the release of vascular endothelial growth factor and in vitro capillary tube formation., The 7th Annual Meeting of the Federation of Asian Dental Anesthesiology Societies, Niigata, Oct. 2014.
24.	Naoji Mita, Shinji Kawahito, Nami Kakuta, 久米克佳, Kazumi Takaishi and Hiroshi Kitahata : Continuous blood glucose monitoring during cardiopulmonary bypass for children., The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 2013.
25.	Naoji Mita, Shinji Kawahito, Nami Kakuta, Katsuyoshi Kume, Kazumi Takaishi and Hiroshi Kitahata : Intraoperative application of the artificial endocrine pancreas., The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 2013.
26.	Shinji Kawahito, Naoji Mita, Nami Kakuta, Kazumi Takaishi and Hiroshi Kitahata : Intensive insulin therapy using an artificial pancreas during liver transplantation., --- Symposium: Artificial Pancreas: What is more sophisticated glycemic control? ---, 5th Congress of the International Federation for Artificial Organs (IFAO 2013), Yokohama, Sep. 2013.
27.	Kazumi Takaishi, Shinji Kawahito, Naoji Mita, Satoru Eguchi, Shigemasa Tomioka and Hiroshi Kitahata : The effects of intravenous anesthetics on in vitro angiogenesis and cell proliferation., Euroanaesthesia 2013, Barcelona, Jun. 2013.
28.	Naoji Mita, Shinji Kawahito, Kazumi Takaishi, Hiroshi Kitahata and Shuzo Oshita : Impact of the newly developed, next-generation artificial dndocrine pancreas., The Annual Meeting of the American Society of Anesthesiologists, Washington, D.C., Oct. 2012.
29.	Kazumi Takaishi, Shinji Kawahito, Nakamura Dai, Tatsuishi Tomoko, Satoru Eguchi, Shigemasa Tomioka and Hiroshi Kitahata : The effects of intravenous anesthetics on the release of vascular endothelial growth factor and angiogenesis., Euroanaesthesia 2012, Paris, Jun. 2012.
30.	Shinji Kawahito, Hiroshi Kitahata, Tsuyoshi Okada, Hirose Kayo and Shuzo Oshita : Continuous blood glucose monitoring and control for patients undergoing hepatic resection., The Annual Meeting of the American Society of Anesthesiologists, Chicago, Oct. 2011.
31.	Shinji Kawahito, Hiroshi Kitahata, Tsuyoshi Okada, Hirose Kayo and Shuzo Oshita : Continuous blood glucose monitoring and control for patients undergoing liver transplantation., The Annual Meeting of the American Society of Anesthesiologists, San Diego, Oct. 2010.
32.	Shinji Kawahito, Hiroshi Kitahata, Nakamura Tomoka, Tsuyoshi Okada and Shuzo Oshita : Usefulness of continuous blood glucose monitoring during cardiovascular surgery., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2009.
33.	Kaori Takata, Yoshinobu Tomiyama, Katsuya Tanaka, Hiroshi Kitahata and Shuzo Oshita : Role of hyperkalemia and Na+/K+ ATPase in myocardial protection during simulated ischemia., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2009.
34.	Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Yoshinobu Tomiyama and Shuzo Oshita : Interaction of the β1-blocker landiolol with early and late sevoflurane-induced preconditioning., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 2009.
35.	Wakamatsu Narutomo, Shinji Kawahito, Hiroshi Kitahata, Goh Ritsuko and Kohyama Arifumi : Landiolol produces cardioprotection in patients undergoing off-pump coronary artery bypass surgery., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 2008.
36.	Shinji Kawahito, Hiroshi Kitahata, Nakamura Tomoka, Akio Iseki and Shuzo Oshita : Continuous intraoperative blood glucose monitoring and control using the STG-22 closed-loop system., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 2008.
37.	Nakamura Tomoka, Shinji Kawahito, Hiroshi Kitahata, Yoshinobu Tomiyama and Shuzo Oshita : Intensive insulin therapy in patients undergoing living-related liver transplantation., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 2008.
38.	Shinji Kawahito, Akio Iseki, Yoshinobu Tomiyama, Hiroshi Kitahata and Shuzo Oshita : High-frequency jet ventilation during thoracoscopic sympathectomy for palmar hyperhidrosis., The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 2007.
39.	Nitta Kazuhito, Shinji Kawahito, Hiroshi Kitahata, Junpei Nozaki and Shuzo Oshita : Accuracy of pulse oximetry and capnography in children with cyanotic congenital heart disease., The Annual Meeting of the American Society of Anesthesiologists, Chicago, Oct. 2006.
40.	Shinji Kawahito, Nakamura Akiyo, Junpei Nozaki, Hiroshi Kitahata and Shuzo Oshita : The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of etomidate., The Annual Meeting of the American Society of Anesthesiologists, Chicago, Oct. 2006.
41.	Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Yoshinobu Tomiyama and Shuzo Oshita : The involvement of the mitochondrial KATP channel on heat-shock protein-induced cardioprotection., The Annual Meeting of the American Society of Anesthesiologists, Chicago, Oct. 2006.
42.	Yoshinobu Tomiyama, Yamaguchi Mikiyo, Satoru Eguchi, Hiroshi Kitahata and Shuzo Oshita : Effects of propofol on the changes in membrane potential induced by simulated ischemia/reperfusion by means of mitochondrial uncoupler in cultured human coronary artery endothelial cells., The Annual Meeting of the American Society of Anesthesiologists, Atlanta, Oct. 2005.
43.	Shinji Kawahito, Junpei Nozaki, Nakamura Akiyo, Hiroshi Kitahata and Shuzo Oshita : Effects of dexmedetomidine and clonidine on vasorelaxation mediated by adenosine triphosphate-sensitive potassium channels in the rat aorta., The Annual Meeting of the American Society of Anesthesiologists, Atlanta, Oct. 2005.
44.	Hiroshi Kitahata, Junpei Nozaki, Shinji Kawahito, Yoshinobu Tomiyama and Shuzo Oshita : Influences of sevoflurane in myocardial protection of an ultra-short-acting β1-blocker, landiolol., The Annual Meeting of the American Society of Anesthesiologists, Atlanta, Oct. 2005.
45.	Junpei Nozaki, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : Sevoflurane enhances geranylgeranylacetone-induced cardioprotection via increased Hsp 70 expression against myocardial ischemia and reperfusion injury in vivo rabbits., The Annual Meeting of the American Society of Anesthesiologists, Las Vegas, Oct. 2004.
46.	Yoshinobu Tomiyama, Tosiko Katayama, Yamaguchi Mikiyo, Hiroshi Kitahata and Shuzo Oshita : Involvement of Na+/K+ ATPase in the response of membrane potential to mannitol-induced hyperosmolality in cultured human coronary endothelial cells., The Annual Meeting of the American Society of Anesthesiologists, Las Vegas, Oct. 2004.
47.	Shinji Kawahito, Takashi Kawano, Junpei Nozaki, Hiroshi Kitahata and Shuzo Oshita : Molecular mechanisms underlying etomidate modulating effects of ATP-sensitive potassium channels., The Annual Meeting of the American Society of Anesthesiologists, Las Vegas, Oct. 2004.
48.	Shinji Kawahito, Takashi Kawano, Katsuya Tanaka, Hiroshi Kitahata and Shuzo Oshita : Effect of midazolam on ATP-sensitive potassium channel activities in vascular smooth muscle cells., The Annual Meeting of the American Society of Anesthesiologists, Las Vegas, Oct. 2004.
49.	Nitta Kazuhito, Hiroshi Kitahata, Shinji Kawahito, Katsuya Tanaka and Shuzo Oshita : The factors influencing contrast effect during intraoperative contrast echocardiography., 9th International Congress of Cardiothoracic and Vascular Anesthesia, Tokyo, Sep. 2004.
50.	Yamanaka Akemi, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : Implication of intraoperative transesophageal ventricular pacing in pediatric patients., 9th International Congress of Cardiothoracic and Vascular Anesthesia, Tokyo, Sep. 2004.
51.	Shinji Kawahito, Hiroshi Kitahata, Junpei Nozaki, Takashi Kawano and Shuzo Oshita : Etomidate has an inhibitory effect on vasorelaxation mediated by adenosine triphosphate-sensitive potassium channels in the rat aorta., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-657, San Francisco, Oct. 2003.
52.	Hiroshi Kitahata, Shinji Kawahito, Junpei Nozaki and Shuzo Oshita : Effects of ischemic preconditioning on the left ventricular work efficiency and the regional wall motion during fentanyl and sevoflurane anesthesia., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-684, San Francisco, Oct. 2003.
53.	Shinji Kawahito, Hiroshi Kitahata, Akio Iseki, Fumihiko Tada, Junpei Nozaki, Akemi Tsuda and Shuzo Oshita : High-frequency jet ventilation during thoracoscopic sympathectomy for palmar hyperhidrosis., 7th America-Japan Anesthesia Congress, Kofu, Oct. 2002.
54.	Hiroshi Kitahata, Shinji Kawahito, Junpei Nozaki, Katsuya Tanaka and Shuzo Oshita : Influences of inhaled gases and administration route on intraoperative contrast echocardiography., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-141, Orlando, Oct. 2002.
55.	Shinji Kawahito, Hiroshi Kitahata, Junpei Nozaki, Katsuya Tanaka and Shuzo Oshita : Hypoxemia during cesarean section: Comparison between obese and normal parturients., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-1067, Orlando, Oct. 2002.
56.	Takashi Kawano, Yasuo Tsutsumi, Shuzo Oshita, Yoshinobu Tomiyama and Hiroshi Kitahata : Effects of propofol and fentanyl on ATP-sensitive potassium channels in cloned pancreatic β-cells., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-51, Orlando, Oct. 2002.
57.	Takashi Kawano, Yasuo Tsutsumi, Shuzo Oshita, Yoshinobu Tomiyama and Hiroshi Kitahata : Effects of propofol on cloned ATP-sensitive potassium channels in ventricular myocytes are different from those in vascular smooth muscle cells., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-50, Orlando, Oct. 2002.
58.	Yoshinobu Tomiyama, Takako Masuda, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita : Propofol inhibits volume-sensitive chloride channels in human coronary artery smooth muscle cells., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-629, New Orleans, Oct. 2001.
59.	Yoshinobu Tomiyama, Takako Masuda, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita : Volume-sensitive chloride channels in human coronary artery smooth muscle cells., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-630, Orlando, Oct. 2001.
60.	Junpei Nozaki, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : Effects of acute normovolemic hemodilution on left ventricular systolic and diastolic function in the absence or presence of -adrenergic blockade in dogs., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-657, Orlando, Oct. 2001.
61.	Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki, Shinji Kawahito and Shuzo Oshita : Effects of ischemic preconditioning on the ultrasonic myocardial tissue characterization and the left ventricular work efficiency during sevoflurane anesthesia in canine stunned myocardium., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-674, New Orleans, Oct. 2001.
62.	Takashi Kawano, Yasuo Tsutsumi, Shuzo Oshita, Mikiko Inatsugi and Hiroshi Kitahata : Effects of fentanyl on adenosine triphosphate-sensitive potassium channels., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-612, New Orleans, Oct. 2001.
63.	Takashi Kawano, Yasuo Tsutsumi, Shuzo Oshita, Mikiko Inatsugi and Hiroshi Kitahata : Blockade of adenosine triphosphate-sensitive potassium channels by propofol in rat ventricular myocytes., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-598, New Orleans, Oct. 2001.
64.	Shinji Kawahito, Tadashi Motomura, Hiroshi Kitahata, Shuzo Oshita and Yukihiko Nose : Feasibility of a new hollow fiber silicone membrane oxygenator for ECMO application., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-401, New Orleans, Oct. 2001.
65.	Katsuya Tanaka, Hiroshi Kitahata, Junpei Nozaki, Tosiko Katayama and Shuzo Oshita : Effects of left ventricular function on arterial pressure following gastrothoracic ventricular pacing., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-170, San Francisco, Oct. 2000.
66.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Risk factors for perioperative myocardial ischemia in carotid endarterectomy., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-390, San Francisco, Oct. 2000.
67.	Yoko Sakai, Hiroshi Kitahata, Yutaka Nakaya and Shuzo Oshita : Propofol-induced relaxation of rat aorta is altered by aging., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-75, San Francisco, Oct. 2000.
68.	Yasuo Tsutsumi, Shuzo Oshita, Hiroshi Kitahata, Takashi Kawano and Yoko Sakai : Effects of thiamylal on adenosine triphosphate-sensitive potassium channels during acidosis., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-619, San Francisco, Oct. 2000.
69.	Junpei Nozaki, Hiroshi Kitahata, Katsuya Tanaka, Akio Iseki and Shuzo Oshita : Influences of acute normovolemic hemodilution on left ventricular systolic and diastolic function in dogs., The Annual Meeting of the American Society of Anesthesiologists, Vol.A-645, San Francisco, Oct. 2000.
70.	Shuzo Oshita, Hiroshi Kitahata, Yoshiaki Hirose, Fumihiko Tada and Yoko Sakai : Ventriculoarterial coupling during anesthesia: Assessment by transesophageal echocardiography and radial artery pressure tracing., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
71.	Junpei Nozaki, Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito and Shuzo Oshita : Effects of acute normovolemic hemodilution on ventriculoarterial coupling in dogs., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
72.	Yasuo Tsutsumi, Shuzo Oshita, Hiroshi Kitahata and Yutaka Nakaya : Effects of thiamylal on adenosine triphosphate-sensitive potassium (KATP) channels in single rat ventricular myocytes., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
73.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Junpei Nozaki and Shuzo Oshita : Intraoperative evaluation of pulmonary artery flow during Fontan procedure., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
74.	Shuzo Oshita, Yasushi Kinoshita, Hiroshi Kitahata, Hiroaki Yasuoka and Takehito Tomino : Succinylcholine-induced flux of catecholamines from normal and denervated skeletal muscle in dogs., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
75.	Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito, Junpei Nozaki and Shuzo Oshita : Feasibility of gastrothoracic ventricular pacing during transesophageal echocardiography - Factors influencing successful ventricular pacing., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
76.	Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Junpei Nozaki and Shuzo Oshita : Intraoperative estimation of cardiac output from pulsed Doppler recording of pulmonary venous flow using transesophageal echocardiography., The Annual Meeting of the American Society of Anesthesiologists, Dallas, Oct. 1999.
77.	Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Hideyuki Kimura and Shuzo Oshita : Effects of sevoflurane on regional myocardial blood flow distribution., --- Quantification with myocardial contrast echocardiography ---, 5th America-Japan Anesthesia Congress, Matsuyama, Oct. 1998.
78.	Shinji Kawahito, Hiroshi Kitahata, Katsuya Tanaka, Hideyuki Kimura and Shuzo Oshita : Intraoperative evaluation of pulmonary artery flow during Fontan procedures., 5th America-Japan Anesthesia Congress, Matsuyama, Oct. 1998.
79.	Yasuo Tsutsumi, Shuzo Oshita, Hiroshi Kitahata and Yutaka Nakaya : Effects of thiamylal on ATP-sensitive potassium channels in single rat ventricular myocytes., 5th America-Japan Anesthesia Congress, Matsuyama, Oct. 1998.
80.	Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Hideyuki Kimura and Shuzo Oshita : Effects of phenylephrine on pulmonary venous flow and arterial oxygenation in patients with tetralogy of Fallot., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
81.	Hiroshi Kitahata, Shinji Kawahito, Katsuya Tanaka, Hideyuki Kimura and Shuzo Oshita : Influence of sevoflurane on regional myocardial blood distribution - Clinical study using myocardial contrast echocardiography., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
82.	Katsuya Tanaka, Hiroshi Kitahata, Shinji Kawahito, Hideyuki Kimura and Shuzo Oshita : Simultaneous transesophageal echocardiography and atrial pacing in patients with valvular heart disease., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
83.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Katsuya Tanaka and Shuzo Oshita : Pulmonary arterial pressure can be estimated by transesophageal pulsed Doppler echocardiography., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
84.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Katsuya Tanaka and Shuzo Oshita : Transesophageal echocardiographic assessment of pulmonary arterial and venous flow during high-frequency jet ventilation., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
85.	Shuzo Oshita, R Kaieda, N Funatsu, Hiroshi Kitahata and Fumihiko Tada : Effects of diltiazem on ventriculo-arterial coupling in humans., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
86.	Tomoko Wada, Hiroshi Kitahata, Hideyuki Kimura, Yutaka Nakaya and Shuzo Oshita : Effects of endothelin (1-31) on tracheal and aortic smooth muscles in rat., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
87.	Hiroshi Kitahata, Katsuya Tanaka, Shinji Kawahito, Hideyuki Kimura and Shuzo Oshita : Transgastric ventricular pacing using transesophageal echocardiographic probe., The Annual Meeting of the American Society of Anesthesiologists, Orlando, Oct. 1998.
88.	Shuzo Oshita, Y-C Park, Hiroshi Kitahata, Hideyuki Kimura and Fumihiko Tada : Norepinephrine potentiates, but lowering temperature of the superfusate attenuates ischemia-induced increases in cytosolic calcium concentrations., The Annual Meeting of the American Society of Anesthesiologists, San Diego, Oct. 1997.
89.	Hideyuki Kimura, Yoshiaki Hirose, Katsuya Tanaka, Shinji Kawahito, Yoshinobu Tomiyama, Hiroshi Kitahata and Shuzo Oshita : Nitric oxide dose not play a major role in regulation of systemic hemodynamic response to acute normovolemic hemodilution., The Annual Meeting of the American Society of Anesthesiologists, San Diego, Oct. 1997.
90.	Tomotsugu Tabata, Takashi Oki, Hirotsugu Yamada, Arata Iuchi, Takaki Hori, Tetsuya Kitagawa, Kato Itsuo, Hiroshi Kitahata, Shuzo Oshita and Susumu Ito : Roles of left atrial appendage for left atrial hemodynamics by left atrial appendage clamping durig cardiac surgery., 69th American Heart Association, New Orleans, Nov. 1996.
91.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura and Shuzo Oshita : Recurrent laryngeal nerve palsy after cardiovascular surgery., --- Relationship to the placement of transesophageal echocardiography probe ---, The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1996.
92.	Hiroshi Kitahata, Shinji Kawahito, Katsuya Tanaka, Hideyuki Kimura and Shuzo Oshita : Effects of sevoflurane on regional myocardial blood distribution., --- The study using myocardial contrast echocardiography ---, The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1996.
93.	Yoshinobu Tomiyama, Satoshi Yasumoto, Hiroshi Kitahata, Hideyuki Kimura and Shuzo Oshita : Coagulation status of the whole blood preoperatively obtained in the operating room and preserved at room temperature: Thrombelastographic evaluation., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1996.
94.	Shuzo Oshita, Y-C Park, Hiroshi Kitahata, Shinji Kawahito and Hideyuki Kimura : Increasing extracellular potassium attenuates ischemia-induced increases in cytosolic calcium concentrations in single rat ventricular myocytes., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1996.
95.	Y-C Park, Shuzo Oshita, Hiroshi Kitahata, Michihisa Kato and Satoshi Yasumoto : Lysophosphatidilcholine increases cytosolic calcium concentrations in single rat ventricular myocytes., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1996.
96.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura and Arifumi Kohyama : Intraoperative contrast echocardiography using Albunex., 9th Asean Congress of Anaesthesiologists, Singapore, Nov. 1995.
97.	Hiroshi Kitahata : Symposium I Trans Esophageal Echocardiography 2. Clinical Applications, a) Valvular Surgery., Inaugural Meeting of Asian Society of Cardiothoracic Anaesthesia, Singapore, Nov. 1995.
98.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura and Arifumi Kohyama : The effects of sevoflurane in regional myocardial blood flow distribution., --- The study using myocardial contrast echocardiography ---, Inaugural Meeting of Asian Society of Cardiothoracic Anaesthesia, Singapore, Nov. 1995.
99.	Tadashi Abe, Keiichi Mori, Ritsuko Gho, Satoshi Yasumoto, Hiroshi Kitahata and Arifumi Kohyama : Hemodilution and oxygen balance during cardiac surgery., Inaugural Meeting of Asian Society of Cardiothoracic Anaesthesia, Singapore, Nov. 1995.
100.	Shinji Kawahito, Hiroshi Kitahata, Hideyuki Kimura, Arifumi Kohyama and Takao Saito : A case of pulmonary arteriovenous fistula in whom venous air embolism during cesarean section may have caused postoperative subendocardial infarction., 8th Congress of the International Cardiac Doppler Society, Sapporo, Jul. 1995.
101.	Takao Saito, Arifumi Kohyama, Seisaku Sakata and Hiroshi Kitahata : Merits and demerits of vasodilation with special reference to coronary hemodynamics and myocardial metabolism., Ist America-Japan Anesthesia Congress, Ohmiya, Sep. 1990.
102.	Hiroshi Kitahata, YW Hong, Paul L. Goldiner and Yasu Oka : Intraoperative left ventricular diastolic filling using transesophageal two-dimensional color Doppler echocardiography -- Effects of vasodilator and inotropic agents., The Annual Meeting of the American Society of Anesthesiologists, New Orleans, Oct. 1989.
103.	Hiroshi Kitahata, YW Hong, Paul L. Goldiner and Yasu Oka : Intraoperative left ventricular diastolic function -- Effects of vasodilator and inotropic agents., Second International Symposium on Echocardiography and Doppler in Cardiac Surgery, Salzburg, May 1989.
104.	Hiroshi Kitahata, Sumi Lee, C Komer, Paul L. Goldiner and Yasu Oka : The usefulness of transesophageal 2-D color Doppler echocardiography in mitral valve Surgery., The 11th Annual Meeting of the Society of Cardiovascular Anesthesiologists, Seattle, Apr. 1989.
105.	Hiroshi Kitahata, C Komer and Yasu Oka : Intraoperative transesophageal two-dimensional (2-d) color Doppler for evaluating mitral valve surgery., First International Symposium on Transesophageal Echocardiography, Mainz, Dec. 1988.
106.	Hiroshi Kitahata, C Komer, Paul L. Goldiner, Edward L. Yellin and Yasu Oka : Left ventricular diastolic filling in patients undergoing coronary artery bypass graft using transesophageal Doppler echocardiography., The Annual Meeting of the American Society of Anesthesiologists, San Francisco, Oct. 1988.
107.	Ritsuko Goh, Hiroshi Kitahata, Arifumi Kohyama, Tomoko Arase and Takao Saito : The effect of sevoflurane on regional myocardial ischemia., International Symposium on Cardiovascular Anesthesiology, Kobe, Aug. 1987.
108.	Takao Saito, Hiroshi Kitahata, Arifumi Kohyama, Tomoko Arase, Seisaku Sakata, Toshiyuki Nakahara and Joji Sangawa : Postinfarction anesthesia and incidence of complications: A preliminary observation., International Symposium on Anaesthesia for Cardiac Patients, Munchen, Sep. 1986.

国内講演発表:

1.	篠島理, 藤原茂樹, 髙田真里菜, 西川美佳, 青木理紗, 江口覚, 高石和美, 北畑洋 : 局所麻酔下歯科治療後にアレルギー反応を繰り返したSjögren症候群患者の全身管理経験, 第49回日本歯科麻酔学会総会・学術集会, 2021年10月.
2.	青木理紗, 髙田真里菜, 篠島理, 西川美佳, 大塚拓, 藤原茂樹, 江口覚, 長宗雅美, 赤池雅史, 高石和美, 北畑洋 : 気管挿管手技における気道管理シミュレータ4種類の比較, 第49回日本歯科麻酔学会総会・学術集会, 2021年10月.
3.	藤原茂樹, 敖金平, 北畑洋 : ワイヤレス給電式医療機器の製作および臨床応用, ICT 2020, 2021年1月. (キーワード) 窒化物半導体膜 (nitride semiconductor films)
4.	箕田直治, 川人伸次, 曽我朋宏, 高石和美, 北畑洋 : 膵全摘術後1週間の皮下間質液中グルコース濃度変動と人工膵臓の有用性, 第58回日本人工臓器学会大会, 2020年11月.
5.	川人伸次, 箕田直治, 曽我朋宏, 高石和美, 北畑洋 : 人工膵臓を用いた小児の術中強化インスリン療法は可能か?, --- パネルディスカッション:人工膵臓は第3の人工臓器になれるのか?:普及に向けた現状と将来展望 ---, 第58回日本人工臓器学会大会, 2020年11月.
6.	武川香織, 高石和美, 真杉幸江, 長岡仁美, 鶴田真生, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 歯科治療時に全身的偶発症/合併症を発症した8 症例:患者急変時に歯科衛生士ができる対応, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
7.	江口覚, 西川美佳, 青木理紗, 藤原茂樹, 高石和美, 北畑洋 : 全身麻酔の術中検査でクレアチンキナーゼ(CK)の異常高値を認めた1 症例, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
8.	髙田真里菜, 川人伸次, 相良亘, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 高石和美, 北畑洋 : カルバマゼピン継続困難な高齢三叉神経痛患者の治療, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
9.	相良亘, 川人伸次, 髙田真里菜, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 高石和美, 北畑洋 : 小柴胡湯・桂枝加芍薬湯併用療法が有効であった三叉神経帯状疱疹後神経痛の2 症例, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
10.	西川美佳, 藤原茂樹, 青木理紗, 江口覚, 高石和美, 大塚拓, 吉田雅彦, 李楊, 敖金平, 北畑洋 : ワイヤレス給電式医療機器の開発―2.45 GHz 帯域 Ver. 1―, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
11.	藤原茂樹, 敖金平, 北畑洋 : ワイヤレス給電式医療機器の製作および臨床応用, ICTイノベーションフォーラム2020 予稿集, 2020年1月. (キーワード) 窒化物半導体膜 (nitride semiconductor films)
12.	高石和美, 川人伸次, 大塚良, 藤原茂樹, 江口覚, 北畑洋 : 鉄貯蔵蛋白からの鉄イオン遊離に関与する還元物質について, 第47回日本歯科麻酔学会総会・学術集会, 2019年10月.
13.	青木一希, 藤原茂樹, 中尾俊介, 李楊, 大塚良, 江口覚, 高石和美, 敖金平, 立原敬一, 北畑洋 : オープンリング共振器を使用した医療機器への無線電力伝送について, 第47回日本歯科麻酔学会総会・学術集会, 2019年10月.
14.	曽我朋宏, 川人伸次, 髙田香, 牧野佐和, 新田一仁, 木下浩之, 高石和美, 北畑洋 : 帝王切開術時の臨床的羊水塞栓症により子宮摘出術を施行した症例, 第40回日本循環制御医学会総会・学術集会, 2019年6月.
15.	大塚良, 山本剛士, 藤原茂樹, 江口覚, 高石和美, 北畑洋 : 喉頭蓋囊胞を有する6症例の全身麻酔経験, 第46回日本歯科麻酔学会総会・学術集会, 2018年10月.
16.	江口覚, 山本剛士, 大塚良, 藤原茂樹, 高石和美, 大塚拓, 吉田雅彦, 北畑洋 : 高齢患者における皮弁を用いた頭頸部再建術の全身麻酔症例の検討, 第46回日本歯科麻酔学会総会・学術集会, 2018年10月.
17.	箕田直治, 里見志帆, 村上千晶, 大山拓朗, 福田浩平, 川人伸次, 木下浩之, 北畑洋, 田中克哉 : TEEガイド下に開胸心筋生検術を施行した転移性心臓腫瘍の症例, 日本心臓血管麻酔学会第23回学術大会, 2018年9月.
18.	箕田直治, 坂東悠太郎, 里美志帆, 曽我朋宏, 富山芳信, 木下浩之, 川人伸次, 田中克哉, 高石和美, 北畑洋 : 脱血管挿入部での縫着のため肺動脈カテーテル抜去困難となり開胸下抜去術が必要になった症例, 第39回日本循環制御医学会総会, 2018年6月.
19.	里美志帆, 川人伸次, 高石和美, 曽我朋宏, 箕田直治, 北畑洋, 田中克哉, 木下浩之 : 臨床使用濃度のセボフルランは，トロンボキサン収縮ラット血管でプロテインキナーゼC活性化を介して内皮機能を抑制する, 第39回日本循環制御医学会総会, 2018年6月.
20.	北畑洋 : 合併症を有する患者の安全な歯科診療を目指して, --- 第一部「全身状態評価とバイタルサイン」;第二部「感染対策と一次救命処置」 ---, 日本歯科麻酔学会主催事業平成29年度「安全な歯科医療のためのバイタルサインセミナー」, 2017年12月.
21.	尾上真奈美, 大塚良, 藤原茂樹, 江口覚, 高石和美, 吉田雅彦, 北畑洋 : 母指内転筋および皺眉筋で筋弛緩モニタリングを行った眼筋型重症筋無力症患者の全身麻酔経験, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
22.	大塚良, 高石和美, 尾上真奈美, 江口覚, 藤原茂樹, 青山智祐, 足立奈由香, 丹羽均, 北畑洋 : 水無脳症患者の歯科治療時の全身麻酔経験, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
23.	江口覚, 尾上真奈美, 大塚拓, 大塚良, 藤原茂樹, 高石和美, 北畑洋 : 血管迷走神経反射既往患者の静脈路確保にミダゾラム経口投与が有用であった1例, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
24.	高石和美, 川人伸次, 尾上真奈美, 大塚良, 江口覚, 藤原茂樹, 北畑洋 : デクスメデトミジンが細胞増殖と細胞遊走に与える影響について, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
25.	藤原茂樹, 大内謙太郎, 尾上真奈美, 大塚良, 江口覚, 高石和美, 北畑洋 : 従来のmodified Mallampati分類および独自に考案したRe modified Mallampati分類とCormack Lehane分類との比較(第二報), 第45回歯科麻酔学会総会·学術集会, 2017年10月.
26.	里見志帆, 川人伸次, 曽我朋宏, 箕田直治, 高石和美, 北畑洋, 木下浩之, 田中克哉 : 重症大動脈狭窄症患者の非心臓手術について, 第38回日本循環制御医学会, 2017年6月.
27.	江口覚, 尾上真奈美, 大塚良, 高石和美, 富岡重正, 北畑洋 : 研修歯科医に対する下顎孔伝達麻酔シミュレーション教育の有用性, 第44回日本歯科麻酔学会総会・学術集会, 2016年10月.
28.	大塚良, 尾上真奈美, 江口覚, 高石和美, 富岡重正, 北畑洋 : 小胞体ストレス応答においてGADD34のC端末は細胞増殖を調整する, 第44回日本歯科麻酔学会総会・学術集会, 2016年10月.
29.	高石和美, 青山智祐, 尾上真奈美, 大塚良, 江口覚, 富岡重正, 川人伸次, 北畑洋 : 口腔外科手術患者の術前心電図における早期再分極およびQT延長の頻度と周術期の経過について, 第44回日本歯科麻酔学会総会・学術集会, 2016年10月.
30.	尾上真奈美, 富岡重正, 大塚良, 高石和美, 江口覚, 北畑洋 : 血管迷走神経反射により2度心停止が生じた症例について考える, 第31回中国・四国歯科麻酔研究会, 2016年7月.
31.	大塚良, 江口覚, 尾上真奈美, 高石和美, 富岡重正, 北畑洋 : 術前検査で発見されたフォン・ウィルブランド病患者の鎮静経験, 第31回中国・四国歯科麻酔研究会, 2016年7月.
32.	大塚良, 原田永勝, 水澤典子, 吉本勝彦, 西辻和親, 高石和美, 中屋豊, 阪上浩, 北畑洋 : GADD34のC末端領域を欠損したCHO-K1細胞の樹立, 第253回徳島医学会学術集会, 2016年7月.
33.	川人伸次, 曽我朋宏, 箕田直治, 堤保夫, 田中克哉, 高石和美, 北畑洋, 木下浩之 : カリウムチャネルと循環, --- シンポジウム「神経調節による循環制御」 ---, 第37回日本循環制御医学会総会, 2016年7月.
34.	曽我朋宏, 川人伸次, 箕田直治, 里見志帆, 片山俊子, 堤保夫, 高石和美, 北畑洋, 木下浩之, 田中克哉 : 心室頻拍合併妊婦に対する脊髄くも膜下硬膜外併用鎮痛法(CSEA)による無痛分娩の1症例, 第37回日本循環制御医学会総会, 2016年7月.
35.	箕田直治, 張雄紀, 里見志帆, 曽我朋宏, 片山俊子, 堤保夫, 川人伸次, 木下浩之, 田中克哉, 高石和美, 北畑洋 : 膵全摘術患者における術後1週間の皮下間質液中グルコース濃度変動, 第37回日本循環制御医学会総会, 2016年7月.
36.	高石和美, 川人伸次, 青山智祐, 尾上真奈美, 大塚良, 江口覚, 富岡重正, 箕田直治, 曽我朋宏, 堤保夫, 木下浩之, 北畑洋 : 術前12誘導心電図におけるJ波出現と周術期の経過について, 第37回日本循環制御医学会総会, 2016年7月.
37.	川人伸次, 曽我朋宏, 片山俊子, 武知浩和, 多田幸雄, 松岡由江, 溝口徹也, 荒瀬友子, 近藤彰, 三木仁司, 北畑洋 : がん疼痛を中心とした混合性疼痛に各種トラマドール製剤が有用であった1症例, 第21回日本緩和医療学会学術大会, 2016年6月.
38.	里見志帆, 曽我朋宏, 川人伸次, 箕田直治, 片山俊子, 若松成知, 久米克佳, 堤保夫, 田中克哉, 北畑洋 : ボリュームビューシステムの術中適応―腎移植術における有用性―, 第43回集中治療医学会学術集会, 2016年2月.
39.	曽我朋宏, 川人伸次, 箕田直治, 片山俊子, 若松成知, 久米克佳, 堤保夫, 田中克哉, 北畑洋 : 緊急V-V ECMOが有効であった，食道癌再発による気道狭窄に対する気管ステント留置の1例, 第43回日本集中治療医学会学術集会, 2016年2月.
40.	北畑洋 : 周術期循環系評価と管理, 昭和大学学士会後援セミナー, 2016年1月.
41.	北畑洋 : 合併症を有する患者の安全な歯科診療を目指して, 第2回平成27年度香歯ポストグラジュエートセミナー医療安全セミナー(外来環対応)/日本歯科麻酔学会バイタルサインセミナー, 2015年12月.
42.	箕田直治, 川人伸次, 曽我朋宏, 田中克哉, 高石和美, 北畑洋 : 高血糖患者における肝切除術中の人工膵臓による血糖コントロールが術後腎機能に与える影響, 第53回日本人工臓器学会大会, 2015年11月.
43.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 北畑洋 : セボフルランが原因と考えられる術後肝機能障害を生じた1例, 第43回日本歯科麻酔学会総会・学術大会, 2015年11月.
44.	高石和美, 川人伸次, 青山智祐, 大塚良, 江口覚, 富岡重正, 北畑洋 : ヒト臍帯静脈血管内皮細胞において静脈麻酔薬が細胞遊走に与える影響, 第43回日本歯科麻酔学会総会・学術大会, 2015年10月.
45.	江口覚, 高石和美, 北畑洋 : 新たに開発した神経ブロックシミュレータを用いた学生教育, 日本臨床麻酔学会第35回大会, 2015年10月.
46.	箕田直治, 川人伸次, 曽我朋宏, 田中克哉, 高石和美, 北畑洋 : 心臓大血管手術中の人工膵臓による血糖コントロールが術後腎機能に与える影響, 日本臨床麻酔学会第35回大会, 2015年10月.
47.	川人伸次, 北畑洋 : TEE研究の方法(成人), --- シンポジウム「TEEと教育研究」 ---, 日本心臓血管麻酔学会第20回学術大会, 2015年10月.
48.	箕田直治, 川人伸次, 濵口英佑, 角田奈美, 田中克哉, 北畑洋 : 心臓血管外科手術中の血糖値連続モニタリングシステムの制度, 日本心臓血管麻酔学会第20回学術大会, 2015年10月.
49.	角田奈美, 川人伸次, 箕田直治, 曽我朋宏, 片山俊子, 多田文彦, 堤保夫, 田中克哉, 高石和美, 北畑洋 : 小児体外循環中の血糖値連続モニタリングの精度, 日本小児麻酔学会第21回大会, 2015年8月.
50.	大塚良, 青山智祐, 江口覚, 高石和美, 富岡重正, 北畑洋 : 気管挿管時に発見した喉頭蓋嚢胞の2 症例, 第30回中国·四国歯科麻酔研究会, 2015年6月.
51.	江口覚, 青山智祐, 大塚良, 高石和美, 富岡重正, 北畑洋 : 下顎孔伝達麻酔・局所浸潤麻酔シミュレーションモデルの開発, 第30回中国·四国歯科麻酔研究会, 2015年6月.
52.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 箕田直治, 曽我朋宏, 川人伸次, 北畑洋 : 長時間の口腔外科手術における循環モニタリングの変遷, 第30回中国·四国歯科麻酔研究会, 2015年6月.
53.	曽我朋宏, 川人伸次, 箕田直治, 若松成知, 片山俊子, 酒井陽子, 堤保夫, 田中克哉, 高石和美, 北畑洋 : 当院における生体腎移植中の循環モニタリングの変遷, 第36回日本循環制御医学会総会, 2015年6月.
54.	箕田直治, 川人伸次, 田中克哉, 高石和美, 北畑洋 : 帝王切開術後に心不全に陥った筋緊張性ジストロフィー妊婦の麻酔経験, 第36回日本循環制御医学会総会, 2015年6月.
55.	河原富也, 廣瀬佳代, 川人伸次, 箕田直治, 中路佳美, 曽我朋宏, 片山俊子, 北畑洋 : 人工膵臓を用いて血糖管理したインスリノーマ切除術の1症例, 日本臨床麻酔学会第34回大会学術集会, 2014年11月. (キーワード) 人工膵臓 / 血糖管理 / インスリノーマ
56.	箕田直治, 川人伸次, 植村勇太, 中路佳美, 河原富也, 福田浩平, 久米克佳, 高石和美, 北畑洋 : 膵全摘術患者における血糖値と間質液中グルコース濃度変動の比較検討, 日本臨床麻酔学会第34回大会学術集会, 2014年11月.
57.	高石和美, 川人伸次, 箕田直治, 北畑洋 : 下壁早期再分極患者においてpropofol単回投与による全身麻酔導入後にJ波増大を認めた一例, 日本臨床麻酔学会第34回大会学術集会, 2014年11月.
58.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 北畑洋 : 特発性間質性肺炎を合併した患者に対する長時間手術の全身麻酔経験, 第42回日本歯科麻酔学会総会・学術集会, 2014年10月.
59.	大塚良, 富岡重正, 桃田幸弘, 青山智祐, 高石和美, 江口覚, 北畑洋 : 血管迷走神経反射による失神時に心拍変動解析を行った1症例, 第42回日本歯科麻酔学会総会・学術集会, 2014年10月.
60.	富岡重正, 青山智祐, 大塚良, 高石和美, 江口覚, 北畑洋 : 骨髄由来間葉系幹細胞から分化誘導した幼若神経細胞に対するリドカインの作用について, 第42回日本歯科麻酔学会総会・学術集会, 2014年10月.
61.	酒井陽子, 川人伸次, 中路佳美, 曽我朋宏, 濵口英佑, 北畑洋 : 生体腎移植時にボリュームビューシステムを用いて循環管理を行った一症例, 日本心臓血管麻酔学会第19回学術大会, 2014年9月.
62.	長井佳香, 清水宗, 高石和美, 青山智祐, 大塚良, 鎌田久美子, 江口覚, 富岡重正, 早雲講二, 北畑洋 : 歯科治療中の全身的偶発症に関するアンケート調査, 第29回中国・四国歯科麻酔研究会, 2014年7月.
63.	青山智祐, 江口覚, 大塚良, 鎌田久美子, 高石和美, 富岡重正, 北畑洋 : 歯科治療終了後に血管迷走神経反射を生じた一例, 第29回中国・四国歯科麻酔研究会, 2014年7月.
64.	大塚良, 富岡重正, 桃田幸弘, 高野栄之, 青山智祐, 鎌田久美子, 高石和美, 江口覚, 北畑洋 : 体位性起立頻拍症候群患者の抜歯時自律神経活動を測定した一例, 第29回中国・四国歯科麻酔研究会, 2014年7月.
65.	鎌田久美子, 高石和美, 高橋章, 工藤隆治, 青山智祐, 大塚良, 江口覚, 富岡重正, 北畑洋 : 気管切開後気管狭窄を有する患者の全身麻酔経験, 第29回中国・四国歯科麻酔研究会, 2014年7月.
66.	箕田直治, 川人伸次, 河原富也, 東島祥代, 高石和美, 北畑洋 : 持続皮下グルコースモニタリングシステムは術中グルコース管理に有用か?, 日本麻酔科学会第61回学術集会, 2014年5月.
67.	酒井陽子, 川人伸次, 松本朋美, 北畑洋 : 小児経食道心エコーの合併症, 日本麻酔科学会第61回学術集会, 2014年5月.
68.	箕田直治, 川人伸次, 久米克佳, 若松成知, 北畑洋 : 持続グルコースモニタと人工膵臓による術中グルコース濃度測定の比較検討, 第41回日本集中治療医学会, 2014年3月.
69.	箕田直治, 中路佳美, 川人伸次, 北畑洋 : 麻酔導入時からBIS値が0を示した汎発性腹膜炎による敗血症性ショックの1症例, 日本臨床麻酔学会第33回大会, 2013年11月.
70.	江口覚, 青山智祐, 大塚良, 高石和美, 富岡重正, 北畑洋 : カルバマゼピン投与により薬疹と意識消失発作を呈した三叉神経痛の1例, 第41回日本歯科麻酔学会総会・学術集会, 2013年10月.
71.	高石和美, 川人伸次, 青山智祐, 大塚良, 江口覚, 富岡重正, 北畑洋 : ミダゾラムがin vitro血管新生に与える影響, 第41回日本歯科麻酔学会総会・学術集会, 2013年10月.
72.	富岡重正, 桃田幸弘, 青山智祐, 大塚良, 高石和美, 江口覚, 北畑洋 : 心拍変動解析を行った起立性調節障害の1症例, 第41回日本歯科麻酔学会総会・学術集会, 2013年10月.
73.	箕田直治, 川人伸次, 久米克佳, 角田奈美, 北畑洋 : 右室流出路狭窄を伴う非破裂性右Valsalva洞動脈瘤の1症例, 日本心臓血管麻酔学会第18回学術集会, 2013年9月.
74.	大塚良, 江口覚, 宮田恵, 青山智裕, 高石和美, 富岡重正, 北畑洋 : 術前の多剤降圧薬内服が原因とみられる麻酔導入後低血圧を認めた1例, 第28回中国・四国歯科麻酔研究会, 2013年7月.
75.	青山智裕, 富岡重正, 宮田恵, 大塚良, 高石和美, 江口覚, 北畑洋 : 重症心疾患を有する患者に対する舌癌手術の麻酔管理, 第28回中国・四国歯科麻酔研究会, 2013年7月.
76.	宮田恵, 高石和美, 青山智裕, 大塚良, 江口覚, 富岡重正, 北畑洋 : 気管挿管練習用モデルでの3種類の喉頭鏡(Macintosh型喉頭鏡，エアウェイスコープ®, McGRATH® )の使用比較, 第28回中国・四国歯科麻酔研究会, 2013年7月.
77.	箕田直治, 川人伸次, 久米克佳, 北畑洋, 大下修造 : 小児体外循環中の血糖値変動‐連続モニタリングによる検討‐, 日本麻酔科学会第60回学術集会, 2013年5月.
78.	高石和美, 川人伸次, 原田永勝, 富山芳信, 北畑洋 : 新生児ラット心筋細胞におけるβ3受容体刺激が一酸化窒素産生に及ぼす影響, 日本麻酔科学会第60回学術集会, 2013年5月.
79.	北畑洋 : 2. 循環系疾患とモニター:簡単なモニターの基礎を含めて歯科医のためのモニタリング講座「明日からの歯科臨床に役立つ生体モニターの活用法」, 第24回日本臨床モニター学会総会, 2013年4月.
80.	佐藤千穂, 冨岡麗子, 山上真樹子, 宮本登志子, 松久宗英, 北畑洋, 武田英二, 金山博臣, 楊河宏章, 木下成三, 川島周 : 徳島県内の医療機関における倫理審査体制に関する状況調査, 第246回徳島医学会学術集会, 2013年2月.
81.	片島るみ, 佐藤千穂, 冨岡麗子, 山上真樹子, 宮本登志子, 木下成三, 川島周, 松久宗英, 北畑洋, 武田英二, 金山博臣, 楊河宏章 : 徳島県内の医療機関における倫理審査体制に関する状況調査, 第33回日本臨床薬理学会年会, 2012年11月.
82.	川人伸次, 北畑洋, 大下修造 : 人工膵臓の術中使用における現状と将来展望―麻酔科医の立場から―, 第50回日本人工臓器学会大会, 2012年11月.
83.	富岡重正, 桃田幸弘, 古北まゆ子, 立石智子, 高瀬奈緒, 高石和美, 江口覚, 北畑洋 : 局所浸潤麻酔のストレスによって誘発された蕁麻疹の1例, 第40回日本歯科麻酔学会総会・学術集会, 2012年10月.
84.	高石和美, 川人伸次, 立石智子, 古北まゆ子, 高瀬奈緒, 江口覚, 富岡重正, 北畑洋 : プロポフォールが血管内皮細胞増殖因子産生と血管新生に与える影響, 第40回日本歯科麻酔学会総会・学術集会, 2012年10月.
85.	大西杏奈, 宮前雅, 金田一弘, 大草知佳, 稲村吉高, 塩見真由美, 越沼静, 小谷順一郎, 高瀬奈緒, 古北まゆ子, 立石智子, 高石和美, 江口覚, 富岡重正, 北畑洋 : セボフルレン・エタノールによる心筋プレコンディショニングの細胞内メカニズムの解明, 第27回中国・四国歯科麻酔研究会, 2012年7月.
86.	江口覚, 高瀬奈緒, 古北まゆ子, 立石智子, 大西杏奈, 高石和美, 富岡重正, 北畑洋 : 下顎骨再建術後の挿管困難が予想された患者に対してエアウェイスコープを用いた意識下挿管の経験, 第27回中国・四国歯科麻酔研究会, 2012年7月.
87.	高瀬奈緒, 高石和美, 古北まゆ子, 立石智子, 大西杏奈, 江口覚, 富岡重正, 北畑洋 : 過去2年間に術前検査でBrugada型心電図を認めた症例, 第27回中国・四国歯科麻酔研究会, 2012年7月.
88.	立石智子, 富岡重正, 古北まゆ子, 高瀬奈緒, 大西杏奈, 江口覚, 北畑洋 : 尋常性天疱瘡患者における頬粘膜腫瘍切除術の全身麻酔経験, 第27回中国・四国歯科麻酔研究会, 2012年7月.
89.	堤保夫, 田中克哉, 神邊紀子, 曽我朋宏, 北畑洋, 大下修造 : 心筋保護作用における吸入麻酔薬とゲラニルゲラニルアセトンの相互作用―細胞膜マイクロドメインに及ぼす影響―, 日本麻酔科学会第59回学術集会, 2012年6月.
90.	箕田直治, 川人伸次, 角田奈美, 北畑洋, 大下修造 : 血糖値連続モニタリング・コントロールシステムの術中適応-各種術式の典型的血糖値変動を中心に-, 日本麻酔科学会第59回学術集会, 2012年6月.
91.	片島るみ, 佐藤千穂, 丸笹美津子, 明石晃代, 高井繁美, 宮本登志子, 山上真樹子, 松久宗英, 北畑洋, 武田英二, 金山博臣, 楊河宏章 : 徳島大学病院における臨床研究推進体制構築の試み, 第32回日本臨床薬理学会年会, 2011年12月.
92.	坂東左知子, 山田博胤, 添木武, 木内誠, 北畑洋, 山口浩司, 竹谷善雄, 岩瀬俊, 若槻哲三, 佐田政隆 : 全身麻酔により顕在性Brugada型心電図の1例, 第105回日本内科学会四国地方会, 2011年11月.
93.	高石和美, 立石智子, 江口覚, 北畑洋 : Brugada型心電図を呈した6症例の術前評価と麻酔経過の検討, 第31回日本臨床麻酔学会(宜野湾市), 2011年11月.
94.	立石智子, 高石和美, 郷律子, 江口覚, 北畑洋 : 小手術を施行した薬剤溶出性ステント留置患者の周術期管理に関する検討, 第31回日本臨床麻酔学会(宜野湾市), 2011年11月.
95.	富岡重正, 立石智子, 榎本奈実, 古北まゆ子, 中村大, 高石和美, 江口覚, 北畑洋 : 脳内グルコーストランスポーターの水輸送機能に対する温度の影響について, 第39回日本歯科麻酔学会総会・学術集会, 2011年10月.
96.	立石智子, 高石和美, 中村大, 古北まゆ子, 榎本奈実, 江口覚, 富岡重正, 北畑洋 : 術前の頸動脈評価が有用であった2症例, 第39回日本歯科麻酔学会総会・学術集会, 2011年10月.
97.	北畑洋 : 心血管疾患と麻酔, 第106回近畿臨床歯科麻酔研究会, 2011年8月.
98.	榎本奈実, 富岡重正, 中村大, 立石智子, 古北まゆ子, 高石和美, 江口覚, 北畑洋 : 全身麻酔後に過換気発作を起こした2症例, 第26回中国・四国歯科麻酔研究会, 2011年7月.
99.	中村大, 江口覚, 立石智子, 古北まゆ子, 榎本奈実, 高石和美, 富岡重正, 北畑洋 : 徳島大学病院歯科外来における救急対応について, 第26回中国・四国歯科麻酔研究会, 2011年7月.
100.	立石智子, 高石和美, 中村大, 古北まゆ子, 北畑洋 : 上顎腫瘍摘出後に尿崩症が疑われた症例, 第26回中国・四国歯科麻酔研究会, 2011年7月.
101.	古北まゆ子, 高石和美, 中村大, 立石智子, 北畑洋 : アルジネードウォーターを使用したERASの試み, 第26回中国・四国歯科麻酔研究会, 2011年7月.
102.	川人伸次, 北畑洋 : 先天性心疾患患者の非心臓手術「非心臓手術を受ける心疾患患者の周術期管理」, 日本麻酔科学会第58回学術集会, 2011年5月.
103.	北畑洋, 川人伸次 : 臨床系各種薬剤の心保護効果と周術期短期予後「周術期の心血管保護」, 日本麻酔科学会第58回学術集会, 2011年5月.
104.	北畑洋 : 歯科における患者評価と危機管理, 第10回日本歯科医療管理学会(四国支部), 2010年10月.
105.	榎本奈実, 高石和美, 江口覚, 富岡重正, 北畑洋 : 口腔外科手術が施行された冠動脈血行再建術既往患者に関する検討, 日本歯科麻酔学会総会・学術集会, 2010年10月.
106.	富岡重正, 高石和美, 江口覚, 北畑洋 : グルコーストランスポーター3の糖輸送機能と水輸送機能に対するペントバルビタールの作用, 日本歯科麻酔学会総会・学術集会, 2010年10月.
107.	江口覚, 高石和美, 富岡重正, 北畑洋 : 徳島大学病院歯科麻酔科外来における手術情報管理システム(ORSYS)導入, 第25回中国・四国歯科麻酔研究会, 2010年7月.
108.	立石智子, 高石和美, 江口覚, 富岡重正, 北畑洋 : FloTracによるStroke volume variation)を指標として循環管理を行った3症例, 第25回中国・四国歯科麻酔研究会, 2010年7月.
109.	榎本奈実, 江口覚, 高石和美, 富岡重正, 北畑洋 : DAM(difficult airway management)カートの手術部設置について, 第25回中国・四国歯科麻酔研究会, 2010年7月.
110.	北畑洋 : 歯科医のための患者評価-循環器を中心に-, 日本口腔外科学会中四国地方会, 2010年5月.
111.	川人伸次, 井関明生, 北畑洋, 河野崇, 髙田香, 神原保, 松本俊夫, 北川哲也, 大下修造 : バージャー病に対する自己単核球細胞移植による血管新生治療, 第41回日本ペインクリニック学会, 2007年7月.
112.	田畑智継, 大木崇, 井内新, 山田博胤, 阿部美保, 加藤逸夫, 北川哲也, 堀隆樹, 大下修造, 北畑洋 : 左心耳の左房血行動態におよぼす影響:心臓手術中における左心耳クランプによる検討, 第44回日本心臓病学会, 1996年9月.

その他・研究会:

1.	西川美佳, 藤原茂樹, 篠島理, 髙田真里菜, 江口覚, 青木理紗, 大塚拓, 斎藤昌司, 吉田雅彦, 高石和美, 川人伸次, 北畑洋 : 成人先天性疾患患者に対する歯科治療時の全身管理2例, 第35回中国・四国歯科麻酔研究会, 2021年8月.
2.	髙田真里菜, 高石和美, 篠島理, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 川人伸次, 北畑洋 : esCCO(非侵襲連続推定心拍出量)測定下にレミマゾラムを使用し全身麻酔を行った高安動脈炎患者の1例, 第35回中国・四国歯科麻酔研究会, 2021年8月.
3.	武川香織, 長岡仁美, 鶴田真生, 真杉幸江, 篠島理, 髙田真里菜, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 高石和美, 川人伸次, 北畑洋 : 歯科外来におけるRRS(Rapid Response System)へ歯科衛生士が介入した1例, 第35回中国・四国歯科麻酔研究会, 2021年8月.
4.	青木一希, 藤原茂樹, 中尾俊介, 江口覚, 八木香奈枝, 三上可菜子, 立原敬一, 李楊, 大塚良, 江口覚, 高石和美, 大浦邦彦, 敖金平, 北畑洋 : 医療機器への無線電力伝送に使用するオープンリング共振器の設計とシミュレーションについて, 第34 回中国・四国歯科麻酔研究会, 2019年7月.
5.	江口覚, 大塚良, 藤原茂樹, 高石和美, 山本剛士, 大塚拓, 吉田雅彦, 北畑洋 : 注射に対する恐怖心の強い自閉スペクトラム症児の吸入鎮静法管理, 第34 回中国・四国歯科麻酔研究会, 2019年7月.
6.	斎藤英里香, 重光健史, 大塚良, 藤原茂樹, 江口覚, 高石和美, 山本剛士, 大塚拓, 吉田雅彦, 河野文昭, 北畑洋 : 輸血拒否のため術式変更を行った気道確保困難患者の全身麻酔経験, 第34 回中国・四国歯科麻酔研究会, 2019年7月.
7.	藤原茂樹, 敖金平, 大塚良, 山本剛士, 江口覚, 高石和美, 北畑洋 : ワイヤレス給電式医療機器の作成と臨床応用に向けた試み, 第33 回中国・四国歯科麻酔研究会, 2018年9月.
8.	山本剛士, 高石和美, 大塚良, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 高度肥満を有する自閉症スペクトラム障害患者に対して全身麻酔を行った2症例, 第33 回中国・四国歯科麻酔研究会, 2018年9月.
9.	大塚良, 高石和美, 山本剛士, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 巨大甲状腺腫を有する患者の全身麻酔経験, 第33 回中国・四国歯科麻酔研究会, 2018年9月.
10.	北畑洋 : 印象記第45回日本歯科麻酔学会総会・学術集会, 臨床麻酔, Vol.41, No.12, 1687-1688, 2017年12月.
11.	大塚良, 高石和美, 新居麻美子, 尾上真奈美, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 歯科治療後に悪心嘔吐を認めた患者の精神沈静法経験, 第32回中国·四国歯科麻酔研究会, 2017年7月.
12.	大塚拓, 江口覚, 尾上真奈美, 大塚良, 藤原茂樹, 高石和美, 北畑洋 : 口腔内浸潤麻酔時に麻酔薬の血管内誤注入が疑われた1例, 第32回中国·四国歯科麻酔研究会, 2017年7月.
13.	尾上真奈美, 高石和美, 工藤景子, 髙丸菜都美, 鎌田久美子, 大塚良, 藤原茂樹, 江口覚, 宮本洋二, 北畑洋 : 根管治療後に下歯槽神経感覚障害が生じた1例, 第32回中国·四国歯科麻酔研究会, 2017年7月.
14.	藤原茂樹, 尾上真奈美, 大塚良, 江口覚, 高石和美, 大塚拓, 吉田雅彦, 北畑洋 : OSASを伴った成人Still病患者の歯科治療時の静脈麻酔経験, 第32回中国·四国歯科麻酔研究会, 2017年7月.
15.	北畑洋 : 安全な歯科臨床を目指した:1. 全身状態評価とバイタルサイン 2. 感染対策と一次救命処置, バイタルサインセミナー, 2011年12月.
16.	北畑洋 : 循環系評価と管理, 群馬バイタルサインセミナー:世界に発信する日本の新しい技術, 2010年9月.

特許:

1.	藤原茂樹, 敖金平, 北畑洋 : 医療用マイクロ波給電システム，医療用受電回路，ショットキーバリアダイオード及び医療用マイクロ波給電方法, (2019年11月), (2020年11月), 特許第201911178977.1号.
2.	藤原茂樹, 敖金平, 北畑洋 : 医療用マイクロ波給電システム，医療用受電回路，ショットキーバリアダイオード及び医療用マイクロ波給電方法, (2019年5月), (2020年11月), 特許第6656698号.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

歯周炎惹起酸化ストレスに鉄代謝が及ぼす影響と体血管反応性改善のための臨床的戦略 (研究課題/領域番号: 20K10181 )
細胞骨格およびIL-17制御を介したヒト腎血管内皮機能維持機構の解明と麻酔薬作用 (研究課題/領域番号: 20K09219 )
精神的ストレスで惹起される循環障害の細胞内機序と麻酔薬の修飾効果に関する研究 (研究課題/領域番号: 18K08873 )
ワイヤレス給電式医療機器の導入に向けた試み (研究課題/領域番号: 18K08857 )
遺伝科学的手法を用いた歯周炎惹起血管異常の予防および治療法の開発と麻酔薬作用 (研究課題/領域番号: 17K11910 )
mTORを介した心筋保護作用　ー虚血再灌流障害に対する新しい治療法の提案ー (研究課題/領域番号: 17K11909 )
細胞骨格ターンオーバー調節物質による細胞内経路制御機構の解明と麻酔薬作用 (研究課題/領域番号: 17K11082 )
長寿遺伝子Sirtuin 3の吸入麻酔薬による心筋保護作用における役割 (研究課題/領域番号: 26463071 )
血管新生のin vitro評価系構築と周術期血管新生医療への貢献 (研究課題/領域番号: 26463070 )
再生医療における血管新生に及ぼす血管プレコンディショニング効果の検討 (研究課題/領域番号: 26462360 )
鉄イオン遊離に関与する還元物質の解明と酸化ストレスに対する局所麻酔薬の影響 (研究課題/領域番号: 23792350 )
ストレス蛋白質誘導による心筋保護作用：多角的心保護戦略を目指して (研究課題/領域番号: 23592994 )
再生医療における血管新生は周術期管理法に影響されるのか？ー高血糖の影響ー (研究課題/領域番号: 23592292 )
再生医療における血管新生は麻酔薬及び周術期管理法に影響されるのか? (研究課題/領域番号: 20591833 )
短時間作用型β1遮断薬術中投与による周術期心筋保護戦略を確立する (研究課題/領域番号: 18591707 )
短時間作用型β1遮断薬による周術期の心筋保護作用は本当に存在するのか? (研究課題/領域番号: 16591545 )
ストレス蛋白質誘導による心筋保護作用に及ぼす麻酔薬の影響 (研究課題/領域番号: 13671587 )
先行虚血、麻酔薬の心筋保護作用におけるミトコンドリアATP感受性Kチャネルの役割 (研究課題/領域番号: 13671586 )
先行虚血後の心筋組織性状に及ぼす麻酔薬の影響 (研究課題/領域番号: 11671502 )
先行虚血の心筋保護作用におけるATP感受性Kチャネルの役割と麻酔薬の影響 (研究課題/領域番号: 11671501 )
心室筋のATP感受性Kチャネルに及ぼすアシドーシス,低酸素,麻酔薬の相互作用 (研究課題/領域番号: 09671568 )
虚血時および再灌流時の心筋細胞内カルシウム濃度変化に及ぼす灌流温低下の効果 (研究課題/領域番号: 07671665 )
心筋局所血流分布に及ぼす吸入麻酔薬の影響 (研究課題/領域番号: 05671267 )
研究者番号（60161486）による検索

名誉教授 : 北畑洋

研究活動

個人のホームページ

専門分野

研究テーマ

著書・論文

著書:

学術論文(審査論文):

学術論文(紀要・その他):

学術レター:

総説・解説:

国際会議:

国内講演発表:

その他・研究会:

特許:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

名誉教授 : 北畑 洋

研究活動

個人のホームページ

専門分野

研究テーマ

著書・論文

著書:

学術論文(審査論文):

学術論文(紀要・その他):

学術レター:

総説・解説:

国際会議:

国内講演発表:

その他・研究会:

特許:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

名誉教授 : 北畑洋