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Tokushima UniversityGraduate School of Biomedical Sciences医学域Medical SciencePathological SciencesDepartment of Immunology and Parasitology
Tokushima UniversityFaculty of MedicineSchool of MedicineCourse of Microbiology and ImmunologyImmunology and Parasitology
Tokushima UniversityResearch ClustersResearch Clusters (Registered)2004008 椎間板炎症部位を可視化する光学ファイバー内蔵型内視鏡の開発
Tokushima UniversityGraduate School of Medical SciencesMedical ScienceCourse of Microbiology and Immunology
Tokushima UniversityInstitute of Post-LED Photonics
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Research Activity

His Web Page

Field of Study

Life sciences [Immunology]
Life sciences [Molecular biology]

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1. Akio Takezaki, Shin-ichi Tsukumo, Yasuhiro Setoguchi, G Julie Ledford, Hisatsugu Goto, Kazuyoshi Hosomichi, Hisanori Uehara, Yasuhiko Nishioka and Koji Yasutomo :
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.,
The Journal of Experimental Medicine, Vol.216, No.12, 2724-2735, 2019.
(Tokushima University Institutional Repository: 114694,   DOI: 10.1084/jem.20182351,   PubMed: 31601679)
2. Chieko Ishifune, Shin-ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Hyun Doo Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano and Koji Yasutomo :
Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.,
PLoS Biology, Vol.17, No.5, 2019.
(Tokushima University Institutional Repository: 114327,   DOI: 10.1371/journal.pbio.3000262,   PubMed: 31071093)
3. Shin-ichi Tsukumo and Koji Yasutomo :
T Cells and Antitumor Immunity by Notch Signaling.,
Frontiers in Immunology, Vol.9, 2018.
(Tokushima University Institutional Repository: 114462,   DOI: 10.3389/fimmu.2018.00101,   PubMed: 29441071)
4. Masanori Niki, Kohhei Nakajima, Daichi Ishikawa, Jun Nishida, Chieko Ishifune, Shin-ichi Tsukumo, Mitsuo Shimada, Shinji Nagahiro, Yoshinori Mitamura and Koji Yasutomo :
MicroRNA-449a deficiency promotes colon carcinogenesis.,
Scientific Reports, Vol.7, No.1, 10696, 2017.
(Tokushima University Institutional Repository: 112383,   DOI: 10.1038/s41598-017-10500-0,   PubMed: 28878284,   Elsevier: Scopus)
5. Sultana Taskia Zaman, Hideki Arimochi, Satoshi Maruyama, Chieko Ishifune, Shin-ichi Tsukumo, Akiko Kitamura and Koji Yasutomo :
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression.,
The Journal of Immunology, Vol.199, No.6, 1989-1997, 2017.
(Tokushima University Institutional Repository: 110921,   DOI: 10.4049/jimmunol.1700645,   PubMed: 28779023)
6. Takahiro Furukawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Yoichi Maekawa, Naoko Matsui, Ryuji Kaji and Koji Yasutomo :
Transmission of survival signals through Delta-like 1 on activated CD4(+) T cells.,
Scientific Reports, Vol.6, 33692, 2016.
(Tokushima University Institutional Repository: 112325,   DOI: 10.1038/srep33692,   PubMed: 27659682,   Elsevier: Scopus)
7. Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita and Koji Yasutomo :
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.,
Nature Medicine, Vol.21, No.1, 55-61, 2015.
(DOI: 10.1038/nm.3758,   PubMed: 25501905,   Elsevier: Scopus)
8. Hiroyuki Kose, Tohru Sakai, Shin-ichi Tsukumo, Kaichun Wei, Takahisa Yamada, Koji Yasutomo and Kozo Matsumoto :
Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats,
Genomics, Vol.89, No.6, 673-677, 2007.
(DOI: 10.1016/j.ygeno.2007.03.001,   PubMed: 17434290)
9. Yuki Hayashi, Naozumi Ishimaru, Rieko Arakaki, Shin-ichi Tsukumo, Hitomi Fukui, Kenji Kishihara, Hiroshi Shiota, Koji Yasutomo and Yoshio Hayashi :
Effective Treatment of a Mouse Model of Sjogren's Syndrome With Eyedrop Administrasiton of Anti-CD4 Monoclonal Antibody,
Arthritis and Rheumatism, Vol.50, No.9, 2903-2910, 2004.
(DOI: 10.1002/art.20472,   PubMed: 15457459)
10. Yuki Hayashi, Shin-ichi Tsukumo, Hiroshi Shiota, Kenji Kishihara and Koji Yasutomo :
Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells,
The Journal of Immunology, Vol.172, No.9, 5240-5248, 2004.
(PubMed: 15100262)
11. Yoichi Maekawa, Shin-ichi Tsukumo, Okada Hiroko, Kenji Kishihara and Koji Yasutomo :
Breakdown of peripheral T-cell tolerance by chronic IL-15 elevation,
Transplantation, Vol.76, No.2, 415-420, 2003.
(DOI: 10.1097/01.TP.0000078900.71840.2B,   PubMed: 12883202)

Review, Commentary:

1. Shin-ichi Tsukumo and Koji Yasutomo :
The regulation of metabolic pathway by Notch signaling,
Science of the Living Body, Vol.70, No.2, 109-113, Mar. 2019.
(CiNii: 40021880949)

Proceeding of International Conference:

1. Chieko Ishifune, Shin-ichi Tsukumo and Koji Yasutomo :
Notch signal controls the number of TCR+CD8+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a2,
Australia-Japan Meeting on Cell Death, Tokyo, May 2018.

Proceeding of Domestic Conference:

1. Shin-ichi Tsukumo, Yoichi Maekawa and Koji Yasutomo :
Aff3 is required for the class switching of IgG2c, IgG1 and IgG3 in a B cell-intrinsic manner,
第48回 日本免疫学会学術集会, Dec. 2019.
2. Shin-ichi Tsukumo and Koji Yasutomo :
Transcriptional elongation factor Aff3 regulates class switching of antibody in B cells,
第47回 日本免疫学会学術集会, Dec. 2018.
3. Shin-ichi Tsukumo and Koji Yasutomo :
自己免疫疾患におけるAFFファミリーの役割,
第33回自己免疫研究会, Jul. 2018.
4. Chieko Ishifune, Shin-ichi Tsukumo and Koji Yasutomo :
Notch signal controls the number of TCRab+CD8aa+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a2,
第46回 日本免疫学会学術集会, Dec. 2017.
5. Shin-ichi Tsukumo and Koji Yasutomo :
DNA結合因子 CTCFのCD4 T細胞における役割,
第31回自己免疫研究会, Jul. 2016.
6. Shin-ichi Tsukumo and Koji Yasutomo :
Function of Notch-Rbpj pathway in naive CD8 T cells,
第44回日本免疫学会学術集会, Nov. 2015.
7. Shin-ichi Tsukumo and Koji Yasutomo :
Notch-Rbpj target genes for maintaining naive and memory T cells,
第43回 日本免疫学会学術集会, Dec. 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 関節リウマチと転写伸長遺伝子Aff3の関連についての解析 (Project/Area Number: 18K08388 )
  • 異なるリガンド環境におけるTリンパ球応答の分子基盤 (Project/Area Number: 18060031 )
  • 糖鎖修飾によるNotchシグナルの修飾とそのTリンパ球における役割 (Project/Area Number: 17790322 )
  • NotchシグナルによるTリンパ球活性化制御機構の解明 (Project/Area Number: 17047027 )
  • Notch分子の糖鎖修飾によるT細胞分化への影響 (Project/Area Number: 17046013 )
  • Notchリガンドを用いた新規癌免疫療法の開発 (Project/Area Number: 17016052 )
  • T lymphocyte-specific gene targeting of Notch receptor glycosyltransferase fringe (Project/Area Number: 16590407 )
  • Notch分子によるヘルパーTリンパ球分化・活性化制御機構の解明 (Project/Area Number: 16017271 )
  • Jagged1を制御することによる癌免疫の増強に関する研究 (Project/Area Number: 15025253 )
  • Tリンパ球の生死を規定する分子機構の解明 (Project/Area Number: 14033233 )
  • 制御性T細胞を用いた抗腫瘍免疫の増強効果に関する研究 (Project/Area Number: 14030061 )
  • Search by Researcher Number (10346596)