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Research Activity

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1. Akio Takezaki, Shin-ichi Tsukumo, Yasuhiro Setoguchi, G Julie Ledford, Hisatsugu Goto, Kazuyoshi Hosomichi, Hisanori Uehara, Yasuhiko Nishioka and Koji Yasutomo :
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.,
The Journal of Experimental Medicine, Vol.216, No.12, 2724-2735, 2019.
(DOI: 10.1084/jem.20182351,   PubMed: 31601679)
2. Chieko Ishifune, Shin-ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Hyun Doo Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano and Koji Yasutomo :
Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.,
PLoS Biology, Vol.17, No.5, 2019.
(DOI: 10.1371/journal.pbio.3000262,   PubMed: 31071093)
3. Shin-ichi Tsukumo and Koji Yasutomo :
T Cells and Antitumor Immunity by Notch Signaling.,
Frontiers in Immunology, Vol.9, 2018.
(DOI: 10.3389/fimmu.2018.00101,   PubMed: 29441071)
4. Masanori Niki, Kohhei Nakajima, Daichi Ishikawa, Jun Nishida, Chieko Ishifune, Shin-ichi Tsukumo, Mitsuo Shimada, Shinji Nagahiro, Yoshinori Mitamura and Koji Yasutomo :
MicroRNA-449a deficiency promotes colon carcinogenesis.,
Scientific Reports, Vol.7, No.1, 10696, 2017.
(Tokushima University Institutional Repository: 112383,   DOI: 10.1038/s41598-017-10500-0,   PubMed: 28878284,   Elsevier: Scopus)
5. Sultana Taskia Zaman, Hideki Arimochi, Satoshi Maruyama, Chieko Ishifune, Shin-ichi Tsukumo, Akiko Kitamura and Koji Yasutomo :
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression.,
The Journal of Immunology, Vol.199, No.6, 1989-1997, 2017.
(DOI: 10.4049/jimmunol.1700645,   PubMed: 28779023)
6. Takahiro Furukawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Yoichi Maekawa, Naoko Matsui, Ryuji Kaji and Koji Yasutomo :
Transmission of survival signals through Delta-like 1 on activated CD4(+) T cells.,
Scientific Reports, Vol.6, 33692, 2016.
(Tokushima University Institutional Repository: 112325,   DOI: 10.1038/srep33692,   PubMed: 27659682,   Elsevier: Scopus)
7. Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita and Koji Yasutomo :
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.,
Nature Medicine, Vol.21, No.1, 55-61, 2015.
(DOI: 10.1038/nm.3758,   PubMed: 25501905,   Elsevier: Scopus)
8. Hiroyuki Kose, Tohru Sakai, Shin-ichi Tsukumo, Kaichun Wei, Takahisa Yamada, Koji Yasutomo and Kozo Matsumoto :
Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats,
Genomics, Vol.89, No.6, 673-677, 2007.
(DOI: 10.1016/j.ygeno.2007.03.001,   PubMed: 17434290)
9. Yuki Hayashi, Naozumi Ishimaru, Rieko Arakaki, Shin-ichi Tsukumo, Hitomi Fukui, Kenji Kishihara, Hiroshi Shiota, Koji Yasutomo and Yoshio Hayashi :
Effective Treatment of a Mouse Model of Sjogren's Syndrome With Eyedrop Administrasiton of Anti-CD4 Monoclonal Antibody,
Arthritis and Rheumatism, Vol.50, No.9, 2903-2910, 2004.
(DOI: 10.1002/art.20472,   PubMed: 15457459)
10. Yuki Hayashi, Shin-ichi Tsukumo, Hiroshi Shiota, Kenji Kishihara and Koji Yasutomo :
Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells,
The Journal of Immunology, Vol.172, No.9, 5240-5248, 2004.
(PubMed: 15100262)
11. Yoichi Maekawa, Shin-ichi Tsukumo, Okada Hiroko, Kenji Kishihara and Koji Yasutomo :
Breakdown of peripheral T-cell tolerance by chronic IL-15 elevation,
Transplantation, Vol.76, No.2, 415-420, 2003.
(DOI: 10.1097/01.TP.0000078900.71840.2B,   PubMed: 12883202)

Review, Commentary:

1. Shin-ichi Tsukumo and Koji Yasutomo :
The regulation of metabolic pathway by Notch signaling,
Science of the Living Body, Vol.70, No.2, 109-113, Mar. 2019.
(CiNii: 40021880949)

Proceeding of International Conference:

1. Chieko Ishifune, Shin-ichi Tsukumo and Koji Yasutomo :
Notch signal controls the number of TCR+CD8+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a2,
Australia-Japan Meeting on Cell Death, Tokyo, May 2018.

Proceeding of Domestic Conference:

1. Shin-ichi Tsukumo, Yoichi Maekawa and Koji Yasutomo :
Aff3 is required for the class switching of IgG2c, IgG1 and IgG3 in a B cell-intrinsic manner,
第48回 日本免疫学会学術集会, Dec. 2019.
2. Shin-ichi Tsukumo and Koji Yasutomo :
Transcriptional elongation factor Aff3 regulates class switching of antibody in B cells,
第47回 日本免疫学会学術集会, Dec. 2018.
3. Shin-ichi Tsukumo and Koji Yasutomo :
自己免疫疾患におけるAFFファミリーの役割,
第33回自己免疫研究会, Jul. 2018.
4. Chieko Ishifune, Shin-ichi Tsukumo and Koji Yasutomo :
Notch signal controls the number of TCRab+CD8aa+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a2,
第46回 日本免疫学会学術集会, Dec. 2017.
5. Shin-ichi Tsukumo and Koji Yasutomo :
DNA結合因子 CTCFのCD4 T細胞における役割,
第31回自己免疫研究会, Jul. 2016.
6. Shin-ichi Tsukumo and Koji Yasutomo :
Function of Notch-Rbpj pathway in naive CD8 T cells,
第44回日本免疫学会学術集会, Nov. 2015.
7. Shin-ichi Tsukumo and Koji Yasutomo :
Notch-Rbpj target genes for maintaining naive and memory T cells,
第43回 日本免疫学会学術集会, Dec. 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 関節リウマチと転写伸長遺伝子Aff3の関連についての解析 (Project/Area Number: 18K08388 )
  • 異なるリガンド環境におけるTリンパ球応答の分子基盤 (Project/Area Number: 18060031 )
  • 糖鎖修飾によるNotchシグナルの修飾とそのTリンパ球における役割 (Project/Area Number: 17790322 )
  • NotchシグナルによるTリンパ球活性化制御機構の解明 (Project/Area Number: 17047027 )
  • Notch分子の糖鎖修飾によるT細胞分化への影響 (Project/Area Number: 17046013 )
  • Notchリガンドを用いた新規癌免疫療法の開発 (Project/Area Number: 17016052 )
  • T lymphocyte-specific gene targeting of Notch receptor glycosyltransferase fringe (Project/Area Number: 16590407 )
  • Notch分子によるヘルパーTリンパ球分化・活性化制御機構の解明 (Project/Area Number: 16017271 )
  • Jagged1を制御することによる癌免疫の増強に関する研究 (Project/Area Number: 15025253 )
  • Tリンパ球の生死を規定する分子機構の解明 (Project/Area Number: 14033233 )
  • 制御性T細胞を用いた抗腫瘍免疫の増強効果に関する研究 (Project/Area Number: 14030061 )
  • Search by Researcher Number (10346596)