Tokushima University / Educator and Researcher Directory --- Hinode, Daisuke

Personal Web Page

https://researchmap.jp/read0017478 (researchmap)

Field of Study

○	Preventive Dentistry

Subject of Study

○	Etiology and prevention of periodontal disease

Book / Paper

Book:

1.	Daisuke Hinode : 歯科衛生士, クインテッセンス出版, Tokyo, Jun. 2020.
2.	Daisuke Hinode and Masami Yoshioka : 栄養と歯科医学, 西村書店, Tokyo, Nov. 2018.
3.	Daisuke Hinode : デンタルスタッフの衛生学・公衆衛生学, Ishiyaku Publishers,Inc., Tokyo, Feb. 2016.
4.	Masami Yoshioka and Daisuke Hinode : 実務における官能評価の留意点∼試験計画・パネル管理・用語選択・データ解析・事例∼ 第10章第5節口臭における官能評価事例について, 株式会社情報機構, Mar. 2013.
5.	尾崎哲則, 埴岡隆, Daisuke Hinode and 他 16名 : 歯科衛生士のための禁煙支援ガイドブック, Ishiyaku Publishers,Inc., Mar. 2013.
6.	Daisuke Hinode : なるほど現代歯塾, Ishiyaku Publishers,Inc., Tokyo, Feb. 2007.
7.	Daisuke Hinode : 口臭診療マニュアル, DAIICHI SHIKA PUBLISHING,CO.,LTD., Tokyo, Jan. 2007.
8.	Daisuke Hinode : 予防歯科実践ハンドブック, Ishiyaku Publishers,Inc., Tokyo, Sep. 2004.
9.	Daisuke Hinode and Ryo Nakamura : 先端医療シリーズ歯科医学2, 先端医療技術研究所, Tokyo, Aug. 2000.
10.	Daisuke Hinode and Ryo Nakamura : 予防歯科臨床教育協議会編集, Ishiyaku Publishers,Inc., Tokyo, Aug. 1999.
11.	Daisuke Hinode, Masami Yoshioka and Ryo Nakamura : 歯と口と健康生きるよろこびを支える口の科学, Ishiyaku Publishers,Inc., Tokyo, Aug. 1998.
12.	R Nakamura, Daisuke Hinode, H Terai and Masami Morioka : Periodontal Disease: Pathogens & Host Immune Responses, --- Extracellular enzymes of Porphyromonas (Bacteroides) gingivalis in relation to periodontal destruction ---, Quintessence Publishing CO.,Ltd., Tokyo, 1991.

Academic Paper (Judged Full Paper):

1.	SONE Ichika, Makoto Fukui, Tokiko Doi, Shimomura Manabu, 岡本好史, 松本侯, Miwa Matsuyama, Masami Yoshioka and Daisuke Hinode : 後期高齢者歯科健康診査受診者の肺炎発症に関わる口腔保健関連因子の分析, Journal of Dental Health, Vol.74, No.2, 116-124, 2024.
2.	Sakuma Ai, Makoto Fukui, Aso Yukio and Daisuke Hinode : Association between motivation scale score and oral condition on receiving basic periodontal therapy, Journal of Dental Health, Vol.74, No.1, 40-51, 2024.
3.	SASAKI Izumi, Makoto Fukui, Harumi Sakamoto, Kanako Tamatani and Daisuke Hinode : 口臭症患者に認められる揮発性硫黄化合物と口腔環境との関連性, Journal of Dental Health, Vol.73, No.3, 197-204, 2023.
4.	Masami Yoshioka, Hiromi Nakae, Makoto Fukui, Shizuko Yanagisawa, Yuka Sogawa, Harumi Sakamoto and Daisuke Hinode : 歯磨き習慣と関連付けたYouTube動画の制作と視聴による教育的効果の検討, Journal of Dental Health, Vol.73, No.3, 205-212, 2023.
5.	Masami Yoshioka, Yoshihiko Noma, Yuichiro Kawashima, Makoto Fukui, Hiromi Nakae, Hiromi Nakae, Shizuko Yanagisawa, Yasuhiko Shirayama and Daisuke Hinode : Factors associated with diabetes control: 2-Year cohort study in outpatients with type 2 diabetes, The Journal of Medical Investigation : JMI, Vol.70, No.1,2, 28-33, 2023. (Summary) Type 2 diabetes is a typical lifestyle disease. We aimed to identify the factors affecting glycemic control in 64 outpatients with type 2 diabetes over a 2-year period. We defined poor glycemic control using a change in glycosylated hemoglobin (?HbA1c) of ??0.5% over 2 years and/or HbA1c ??7.5% at the end of the study period. We used a questionnaire to collect information on oral health behavior and lifestyle, including eating and smoking habits, and analyzed the relationships between indices of diabetes control and responses to the questionnaire. The mean (SD) HbA1c of the participants was 6.87% (0.77%) at a baseline, and 6.93% (0.69%) after 2 years. Twenty-three participants (36.0%) had poor glycemic control. ?HbA1c and the change in body mass index (?BMI) correlated (Spearman's rank correlation, r?=?0.350, p?<?0.01). The HbA1c at baseline was associated with eating slowly?/?chewing well, and ?BMI was associated with perceived oral symptoms. Binominal logistic regression analysis revealed that poor glycemic control was associated with ?BMI and a smoking habit (odds ratio : 1.62, 95% confidence interval : 1.08?2.42?;?and 4.01, 1.12?14.36, respectively). These findings imply that weight gain and a smoking habit are associated with poor glycemic control in patients with type 2 diabetes. J. Med. Invest. 70 : 28-33, February, 2023. (Keyword) Humans / Diabetes Mellitus, Type 2 / Glycated Hemoglobin / Cohort Studies / Blood Glucose / Outpatients / Hyperglycemia (Tokushima University Institutional Repository) ● Metadata: 118298 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.28 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164734 ● Search Scopus @ Elsevier (PMID): 37164734 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.28 (Tokushima University Institutional Repository: 118298, DOI: 10.2152/jmi.70.28, PubMed: 37164734)
6.	Tokiko Doi, Makoto Fukui, Masami Yoshioka, Okamoto Yoshifumi, Shimomura Manabu, Matsumoto Kimi, Miwa Matsuyama and Daisuke Hinode : The relationship between subjective oral frailty and adverse health outcomes or medical and dental expenditures in the latterstage older adult: A 6year longitudinal study., Clinical and Experimental Dental Research, Vol.9, No.2, 349-357, 2023. (Keyword) subjective oral frailty / adverse health outcomes / medical and dental expenditures / older adult
7.	Harumi Sakamoto, Makoto Fukui, Tokiko Doi, Masami Yoshioka and Daisuke Hinode : Factors influencing dental caries in 3-year-old children: Effectiveness through prenatal oral health examination on the behavioral change, Journal of Dental Health, Vol.73, No.1, 31-41, 2023. (Tokushima University Institutional Repository) ● Metadata: 118192 (Tokushima University Institutional Repository: 118192)
8.	KUBO Eri, Makoto Fukui, Harumi Sakamoto and Daisuke Hinode : Analysis of Factors Related to Periodontal Condition in Pregnant Women, Journal of Dental Health, Vol.73, No.1, 21-30, 2023. (Keyword) 妊婦 / 歯周状態 / かかりつけ歯科医 / 補助的清掃用具 / Pregnant women / Periodontal condition / Family dentist / Adjunctive oral hygiene device (Tokushima University Institutional Repository) ● Metadata: 118218 (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.73.1_21 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390858066754105344 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.73.1_21 (Tokushima University Institutional Repository: 118218, DOI: 10.5834/jdh.73.1_21, CiNii: 1390858066754105344)
9.	Makoto Fukui, Asakuma Hiroki, Horiuchi Hiroko, Takii Hiroshi, Masami Yoshioka and Daisuke Hinode : Oral care tablet containing kiwifruit powder affects tongue coating microbiome, Clinical and Experimental Dental Research, Vol.8, No.3, 721-728, 2022. (Tokushima University Institutional Repository) ● Metadata: 118598 (Link to Publication Site) ● Publication site (DOI): 10.1002/cre2.591 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/cre2.591 (Tokushima University Institutional Repository: 118598, DOI: 10.1002/cre2.591)
10.	Kumiko Sahara, Makoto Fukui, Harumi Sakamoto, Tokiko Doi, Masami Yoshioka, 岡本好史, 松本侯, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : 後期高齢者の口腔状態と要介護認定または死亡発生との関連性, Journal of Dental Health, Vol.72, No.2, 106-114, 2022. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.72.2_106 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.72.2_106 (DOI: 10.5834/jdh.72.2_106)
11.	Akihiro Wada, Keiji Murakami, Yumi Ishikawa, Takashi Amoh, Kouji Hirao, Yuki Hosokawa, Daisuke Hinode, Yoichiro Miyake and Hiromichi Yumoto : Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes, BioMed Research International, Vol.2022, 9770899, 2022. (Summary) Periodontitis is a chronic inflammatory disease caused by periodontopathogenic bacteria that form biofilms in periodontal pockets. The gingival epithelium acts as the first physical barrier in fighting attacks by periodontopathogenic pathogens, such as the primary etiological agent , and various exogenous chemicals, as well as regulates the local innate immune responses. Therefore, the development of novel oral care products to inhibit inflammatory reactions caused by bacterial infection and protect the gingival epithelium is necessary. L. has generally been used as an indigenous medicine, such as a diuretic, an antipyretic, and an analgesic, in ancient practice. In this study, we examined the effects of a water extract from L. on the inhibition of the inflammatory reaction elicited by bacterial infection and protection of the oral epithelium by chemical irritation. Pretreatment of oral epithelial cells with the water extract from L. significantly reduced or its lipopolysaccharide- (LPS-) mediated production of chemokines (interleukin-8 and C-C-chemokine ligand20) in a concentration-dependent manner with comparable to or greater effects than epigallocatechin gallate and protected oral epithelial cells from injury by chemical irritants, cetylpyridinium chloride, and benzethonium chloride. Moreover, the water extract from . L. in the presence of antimicrobial agents or antifibrinolytics already used as ingredients in mouthwash could significantly reduce the production of chemokines from LPS-stimulated oral epithelial cells in a concentration-dependent manner. These findings suggest that the water extract from . L. is potentially useful for oral care to prevent oral infections, such as periodontal infections, and maintain oral epithelial function. (Keyword) Anti-Inflammatory Agents / Bacteroidaceae Infections / Cell Line, Transformed / Humans / Keratinocytes / Magnoliopsida / Mouth Mucosa / Periodontitis / Plant Extracts / Porphyromonas gingivalis (Tokushima University Institutional Repository) ● Metadata: 117031 (Link to Publication Site) ● Publication site (DOI): 10.1155/2022/9770899 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35028318 ● Summary page in Scopus @ Elsevier: 2-s2.0-85123567270 (Tokushima University Institutional Repository: 117031, DOI: 10.1155/2022/9770899, PubMed: 35028318, Elsevier: Scopus)
12.	Masami Yoshioka, 川島友一郎, Makoto Fukui, Shizuko Yanagisawa, Hiromi Nakae, Yuka Sogawa and Daisuke Hinode : 糖尿病患者における間食習慣および口腔保健行動と口腔環境との関連性, Journal of Dental Health, Vol.71, No.4, 215-222, 2021. (Keyword) 糖尿病 / 間食習慣 / 口腔保健行動 / 口腔環境 / 多項目唾液検 / Diabetes / Snacking habit / Oral health behavior / Oral environment / Salivary multi-test system / トウニョウビョウ / カンショクシュウカン / コウコウホケンコウドウ / コウコウカンキョウ / タコウモクダエキケン (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520009410453382528 (CiNii: 1520009410453382528)
13.	Natsumi Fujiwara, 久野恵, 田村真里奈, 篠永晴美, 迎美榛, Harumi Sakamoto, Mariko Seyama, Kazumi Ozaki and Daisuke Hinode : 歯科衛生士学生における摂食嚥下リハビリテーション臨床実習の有効性, The Journal of Japan Society for Dental Hygiene, Vol.15, No.2, 29-37, 2021. (Keyword) 歯科衛生士学生 / 臨床実習 / 摂食嚥下リハビリテーション / 多職種連携 / 専門性 / シカエイセイシガクセイ / リンショウジッシュウ / セッショクエンカリハビリテーション / タショクシュレンケイ / センモンセイ (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520854806140649088 (CiNii: 1520854806140649088)
14.	Masami Yoshioka, Yuichiro Kawashima, Yoshihiko Noma, Makoto Fukui, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai and Daisuke Hinode : Association between Diabetes-related Clinical Indicators and Oral Health Behavior among Type-2 Diabetes Patients, The Journal of Medical Investigation : JMI, Vol.68, No.1,2, 140-147, 2021. (Summary) Objective : The aim of this study was to evaluate the association between diabetes-related indicators and oral health behavior among patients with type 2 diabetes. Methods : Seventy-four outpatients were included. We administered a questionnaire and divided the patients into two groups according to oral health behavior and eating habits. We then compared diabetes-related clinical records between the groups and performed logistic regression analysis. Results : Participants who brushed their teeth before bedtime every night had lower BMIs than those who did not. Participants who reported eating slowly and chewing well every day had significantly lower HbA1c than their counterparts. Participants who reported gum bleeding had significantly higher LDL-cholesterol than their counterparts. Binominal logistic regression analysis revealed that BMI < 25 was associated with not brushing teeth before bedtime every night, HbA1c < 7.5 with not eating slowly or chewing well every day, and LDL-cholesterol < 120 with gum bleeding (odds ratio : 0.140, 95% confidence interval : 0.036-0.540 ; OR : 0.085, 95% CI : 0.010-0.736, OR : 0.275, 95% CI : 0.077-0.979, respectively). Conclusions : Our findings suggest that toothbrushing before bedtime every night is associated with reduced risk of obesity and that eating slowly and chewing well are advantageous for glycemic control in patients with type 2 diabetes.J. Med. Invest. 68 : 140-147, February, 2021. (Keyword) Body Mass Index / Diabetes Mellitus, Type 2 / Feeding Behavior / Health Behavior / Humans / Toothbrushing (Tokushima University Institutional Repository) ● Metadata: 116003 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.140 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994459 ● Search Scopus @ Elsevier (PMID): 33994459 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.140 (Tokushima University Institutional Repository: 116003, DOI: 10.2152/jmi.68.140, PubMed: 33994459)
15.	Tokiko Doi, Makoto Fukui, Harumi Sakamoto, Hiromi Nakae, Junji Komoda, Omar Maningo Rodis and Daisuke Hinode : There is an association between gingival inflammation and obesity in Japanese male adolescents, Journal of Oral Health and Biosciences, Vol.33, No.2, 29-34, 2021. (Keyword) Gingival inflammation / obesity / Lifestyle habits / Adolescents / Cohort study (Tokushima University Institutional Repository) ● Metadata: 115636 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.33.2_33 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1391412881287168000 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.33.2_33 (Tokushima University Institutional Repository: 115636, DOI: 10.20738/johb.33.2_33, CiNii: 1391412881287168000)
16.	Yuka Sogawa, Makoto Fukui, Shingen Nakamura, Kimiko Sogabe, Ryohei Sumitani, Masami Yoshioka, Masahiro Abe and Daisuke Hinode : Involvement of oral bacteria and oral immunity as risk factors for chemotherapy- induced fever with neutropenia in patients with hematological cancer, International Journal of Hematology, Vol.112, No.6, 851-859, 2020. (Summary) The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p < 0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p < 0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cutoff point based on the AUC in the F. nucleatum/sIgA ratio was 0.023, and this model had a 78.4% probability (p < 0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum/sIgA ratio (HR 66.06, p < 0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors. (Keyword) Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Bacterial Load / Febrile Neutropenia / female / Fusobacterium nucleatum / Hematologic Neoplasms / Humans / Immunoglobulin A, Secretory / male / Middle Aged / Mouth / Risk Factors / Young Adult (Tokushima University Institutional Repository) ● Metadata: 115932 (Link to Publication Site) ● Publication site (DOI): 10.1007/s12185-020-02975-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32880823 ● Summary page in Scopus @ Elsevier: 2-s2.0-85090162636 (Tokushima University Institutional Repository: 115932, DOI: 10.1007/s12185-020-02975-x, PubMed: 32880823, Elsevier: Scopus)
17.	Minami Watanabe, Harumi Sakamoto, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : Relationship between smoking habits of mothers and dental health behavior or the oral health condition of their children, Japanese Journal of Smoking Control Science, Vol.14, No.10, 1-7, 2020. (Summary) Objective: It is known that secondhand smoke exposure is associated with dental caries in children, and it is also speculated that mothers with smoking habits may have little awareness of their dental health and their children. The purpose of this study was to analyze the relationship between smoking habits of mothers and dental health behavior or the oral health condition of their children, and to clarify the factors involved in dental caries of deciduous teeth.Methods: The subjects enrolled in this study were mothers and their children who received health checkup for both 18-month-old children and 3-year-old children in N City, Tokushima Prefecture, Japan. One hundred sixty-five subjects (mothers) were divided into two groups, non-smoker group (n=152) and smoker group (n=13). The results of dental examinations for 3-year-old children and the questionnaire surveys from mothers were collated and analyzed.Results: Dental caries prevalence of deciduous teeth was 46.2% in children of the smoker group, which was significantly higher than that of 21.1% in children of the non-smoker group (p<0.05). Among the questionnaire survey items regarding the regular dental checkup of mothers, the percentage of "no visit" in the smoker group was 76.9% and 46.1% in the non-smoker group, and it showed a significant difference (p<0.05). In the item of the dental examination for pregnant woman, the percentage of "did not receive" in the smoker group was 76.9% and 43.7% in the non-smoker group, and it showed a significant difference (p<0.05). There were significant differences between the presence and absence of smoking habits of mothers regarding the age of mother (p<0.01) and smoking habits of the other families (p<0.05). In addition, the binomial logistic regression analysis showed that oral hygiene condition (OR=2.92, p<0.05), regular between meal eating (OR=3.99, p<0.01) and smoking habits of mothers (OR=4.13, p<0.05) were significantly corelated with the presence of dental caries in 3-year-old children.Conclusions: These results suggest that the mothers in the smoking group was younger and higher rate that included smoker families, in addition to poor regular dental check-up during pregnancy and currently. It was also suggested that smoking habits of mothers were associated with dental caries in 3-year-old children. (Keyword) Pregnant women / Smoking / Dental caries of deciduous teeth / Maternal and child health (Tokushima University Institutional Repository) ● Metadata: 116173 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390006585527134720 (Tokushima University Institutional Repository: 116173, CiNii: 1390006585527134720)
18.	Masami Yoshioka, Yoshifumi Okamoto, Masahiro Murata, Makoto Fukui, Shizuko Yanagisawa, Yasuhiko Shirayama, Kojiro Nagai and Daisuke Hinode : Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men, Journal of Diabetes Research, Vol.2020, 4042129, 2020. (Tokushima University Institutional Repository) ● Metadata: 115663 (Link to Publication Site) ● Publication site (DOI): 10.1155/2020/4042129 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1155/2020/4042129 (Tokushima University Institutional Repository: 115663, DOI: 10.1155/2020/4042129)
19.	Matsumura Yuki, Daisuke Hinode, Makoto Fukui, Masami Yoshioka, Asakuma Hiroki and Takii Hiroshi : Effectiveness of an oral care tablet containing kiwifruit powder in reducing oral bacteria in tongue coating: A crossover trial, Clinical and Experimental Dental Research, Vol.6, No.2, 197-206, 2020. (Summary) The aim of this study was to investigate the effect of an oral care tablet containing kiwifruit powder on oral bacteria in tongue coating compared with tongue brushing. Thirty-two healthy, young adults were enrolled, and a crossover clinical trial was conducted. The volatile sulfur compound (VSC) concentration, Winkel tongue-coating index (WTCI), and the number of total bacteria in addition to Fusobacterium nucleatum in tongue coating were measured. We instructed subjects to remove tongue coating by tongue brush for Intervention I, to keep the oral care tablet containing kiwifruit powder on the tongue dorsum and to let it dissolve naturally for Intervention II, and three oral care tablets 1 day before the measurement for Intervention III. There were significant differences in terms of the level of H S, VSC, and WTCI at Intervention I and all evaluation values at Intervention II. There were significant differences in terms of the level of H S, VSC, WTCI, the number of total bacteria, and F. nucleatum at Intervention III. The value of WTCI, the number of bacteria, and F. nucleatum decreased significantly after taking the oral care tablets than after tongue brushing. When compared with Interventions I and III, Intervention III showed the effective results; there were significant differences in the number of total bacteria and F. nucleatum between tongue brushing and taking tablets. These results suggested that the oral care tablet containing kiwifruit powder could be effective in reducing total bacteria and F. nucleatum in tongue coating when compared with tongue brushing. (Tokushima University Institutional Repository) ● Metadata: 115838 (Link to Publication Site) ● Publication site (DOI): 10.1002/cre2.262 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32250572 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076095991 (Tokushima University Institutional Repository: 115838, DOI: 10.1002/cre2.262, PubMed: 32250572, Elsevier: Scopus)
20.	Yumi Kuwamura, Eijiro Sakamoto, Masuko Sumikawa, Munehide Matsuhisa, Daisuke Hinode, Hirokazu Uemura and Sachi Kishida : Assessing the oral health of in-patients with diabetes using a clinical version of the diabetes oral health assessment tool© and its association with dental examinations, The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 328-336, 2019. (Tokushima University Institutional Repository) ● Metadata: 114163 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.66.328 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656299 ● Search Scopus @ Elsevier (PMID): 31656299 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.328 (Tokushima University Institutional Repository: 114163, DOI: 10.2152/jmi.66.328, PubMed: 31656299)
21.	森山聡美, Daisuke Hinode, Masami Yoshioka, Yuka Sogawa, Fumiaki Kawano and Hiroki Iga : 食道がん化学療法患者に対するがん支持療法としての専門的口腔ケアの有用性, Journal of Dental Health, Vol.69, No.3, 139-142, 2019. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.69.3_139 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845713086512128 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.69.3_139 (DOI: 10.5834/jdh.69.3_139, CiNii: 1390845713086512128)
22.	Satomi Moriyama, Daisuke Hinode, Masami Yoshioka, Yuka Sogawa, Takeshi Nishino, Akira Tangoku and Daniel Grenier : Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy: a clinical trial for oral hygiene and oral condition, The Journal of Medical Investigation : JMI, Vol.65, No.3,4, 184-190, 2018. (Summary) The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Twenty-three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups:7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the control group (psize 8 < 0.05). No such differences were observed for the group receiving Hangeshashinto. This clinical trial showed that Daiokanzoto might be effective in attenuating gingival inflammation and reducing the levels of periodontopathogenic bacteria in patients with esophageal cancer. J. Med. Invest. 65:184-190, August, 2018. (Keyword) Aged / Antineoplastic Agents / Bacterial Load / Campylobacter rectus / Drugs, Chinese Herbal / Esophageal Neoplasms / Female / Fusobacterium nucleatum / Gingivitis / Humans / Male / Medicine, Kampo / Middle Aged / Oral Hygiene / Periodontal Index / Plant Extracts / Stomatitis (Tokushima University Institutional Repository) ● Metadata: 112235 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.65.184 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282858 ● Summary page in Scopus @ Elsevier: 2-s2.0-85054441144 (Tokushima University Institutional Repository: 112235, DOI: 10.2152/jmi.65.184, PubMed: 30282858, Elsevier: Scopus)
23.	MP Veilleux, Satomi Moriyama, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : A review of evidence for a therapeutic application of traditional Japanese Kampo medicine for oral diseases/disorders., Medicines, Vol.5, No.2, 2018. (Summary) Kampo medicines prescribed by specialized medical practitioners and Japanese physicians have gradually reemerged in Japan as alternatives to Western medications. Kampo formulations are composed of several plant extracts and, as such, the broad variety of phytochemicals they contain likely act synergistically to provide their beneficial effects. Kampo medicines have traditionally been prescribed for a number of health conditions, including chronic hepatitis, bronchial asthma, anemia, etc. The aim of this article is to review the beneficial effects of Kampos with respect to oral health. Pertinent papers published between 1970 and 2017 were retrieved by searching in PubMed, ScienceDirect, Web of Science, and Scopus using key words followed by evaluation of the relevant articles. In vitro studies have identified a number of properties that give credence to the potential of Kampos for treating or preventing oral diseases/disorders. Given their anti-microbial and anti-inflammatory properties, they may be promising agents for controlling periodontal diseases, oral mucositis, xerostomia, and drug-induced gingival overgrowth. Since some oral diseases have a complex etiology that involves microbial pathogens and the host immune response, agents with dual functionality such as Kampo phytochemicals may offer a therapeutic advantage. (Tokushima University Institutional Repository) ● Metadata: 117744 (Link to Publication Site) ● Publication site (DOI): 10.3390/medicines5020035 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29670027 ● Search Scopus @ Elsevier (PMID): 29670027 ● Search Scopus @ Elsevier (DOI): 10.3390/medicines5020035 (Tokushima University Institutional Repository: 117744, DOI: 10.3390/medicines5020035, PubMed: 29670027)
24.	Miki Satoh, Arisa Kurokawa, Hiroko Sugimoto, Yuko Yasuhara, Hiromi Nakae, Yukari Shinohara, Tetsuya Tanioka, Hiroki Iga, Daisuke Hinode, Yoshihiro Suzuki, Souichi Honda and Rozzano De Castro Locsin : Relationship among Health Related Quality of Life, Quality of Sleep, and Oral Health Condition, Health, Vol.10, No.2, 204-214, 2018. (Keyword) Health Related Quality of Life / Body-Mass Index / Quality of Sleep / Oral Condition / Over 55 Years Old / Middle Aged and Older Japanese Adults (Link to Publication Site) ● Publication site (DOI): 10.4236/health.2018.102017 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4236/health.2018.102017 (DOI: 10.4236/health.2018.102017)
25.	Akika Yamasaki, Masami Yoshioka, Takashi Bando and Daisuke Hinode : 血液透析患者における現在歯数および咬合支持状態と栄養状態との関連性, Journal of Dental Health, Vol.68, No.1, 2-8, 2018. (Tokushima University Institutional Repository) ● Metadata: 111289 (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.68.1_2 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679979081216 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.68.1_2 (Tokushima University Institutional Repository: 111289, DOI: 10.5834/jdh.68.1_2, CiNii: 1390282679979081216)
26.	Yui Okazawa, Daisuke Hinode, Masami Yoshioka, Tokiko Doi, Hiromi Nakae, Yuka Sogawa and Daniel Grenier : Comparison of oral malodor and oral microbiome in smokers and non-smokers, Japanese Journal of Smoking Control Science, Vol.11, No.6, 1-9, 2017. (Link to Publication Site) ● Publication site (DOI): 10.32213/jascs.vol.11.06_1 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.32213/jascs.vol.11.06_1 (DOI: 10.32213/jascs.vol.11.06_1)
27.	Masami Yoshioka, Takashi Bando, Yasuhiko Shirayama, Issei Imoto, Shizuko Yanagisawa, 横山希実, Yuko Takeuchi and Daisuke Hinode : 透析患者の歯科受診を推進するためのツールとしての医療職および患者向けリーフレットの開発, Journal of Dental Health, Vol.67, No.2, 84-88, 2017. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.67.2_84 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679980645248 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.67.2_84 (DOI: 10.5834/jdh.67.2_84, CiNii: 1390282679980645248)
28.	Masami Yoshioka, 中野敦子, 橋本寛文, Yasuhiko Shirayama, Shizuko Yanagisawa, Yuko Takeuchi, Daisuke Hinode and Issei Imoto : 血液透析患者における口腔衛生管理に対する意識, Journal of Shikoku Public Health Society, Vol.62, No.1, 89-93, 2017.
29.	Hiromi Nakae, Masami Yoshioka, 薮内さつき, Tokiko Doi, Natsumi Fujiwara, Hiroki Iga and Daisuke Hinode : 徳島県内の回復期病院における看護師の口腔ケアに対する認識ーアンケート調査結果からー, Journal of Shikoku Public Health Society, Vol.62, No.1, 95-99, 2017. (Keyword) 回復期病院 / 口腔ケア / アンケート調査 / 看護師
30.	渋谷莉加, 岡澤悠衣, Daisuke Hinode, Tokiko Doi, Hiromi Nakae, Kanako Tamatani, Masami Yoshioka and 米津隆仁 : 幼児のフッ化物配合歯磨剤利用に関する口腔保健行動, Journal of Dental Health, Vol.66, No.5, 475-480, 2016. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.66.5_475 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679981373440 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.66.5_475 (DOI: 10.5834/jdh.66.5_475, CiNii: 1390282679981373440)
31.	Tokiko Doi, Daisuke Hinode, Hiromi Nakae, Masami Yoshioka, Miwa Matsuyama, Hiroki Iga and Fukushima Yuzuru : Relationship between Chewing Behavior and Oral Conditions in Elementary School Children Based on the "Chewing 30" Program: An Intervention Study, Journal of Dental Health, Vol.66, No.5, 438-444, 2016. (Tokushima University Institutional Repository) ● Metadata: 111210 (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.66.5_438 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.66.5_438 (Tokushima University Institutional Repository: 111210, DOI: 10.5834/jdh.66.5_438)
32.	Masami Yoshioka, Yasuhiko Shirayama, Issei Imoto, Daisuke Hinode, Shizuko Yanagisawa, Yuko Takeuchi, Takashi Bando and N Yokota : Factors associated with regular dental visits among hemodialysis patients., World Journal of Nephrology, Vol.5, No.5, 455-460, 2016. (Summary) To investigate awareness and attitudes about preventive dental visits among dialysis patients; to clarify the barriers to visiting the dentist. Subjects included 141 dentate outpatients receiving hemodialysis treatment at two facilities, one with a dental department and the other without a dental department. We used a structured questionnaire to interview participants about their awareness of oral health management issues for dialysis patients, perceived oral symptoms and attitudes about dental visits. Bivariate analysis using the (2) test was conducted to determine associations between study variables and regular dental check-ups. Binominal logistic regression analysis was used to determine factors associated with regular dental check-ups. There were no significant differences in patient demographics between the two participating facilities, including attitudes about dental visits. Therefore, we included all patients in the following analyses. Few patients (4.3%) had been referred to a dentist by a medical doctor or nurse. Although 80.9% of subjects had a primary dentist, only 34.0% of subjects received regular dental check-ups. The most common reasons cited for not seeking dental care were that visits are burdensome and a lack of perceived need. Patients with gum swelling or bleeding were much more likely to be in the group of those not receiving routine dental check-ups ((2) test, P < 0.01). Logistic regression analysis demonstrated that receiving dental check-ups was associated with awareness that oral health management is more important for dialysis patients than for others and with having a primary dentist (P < 0.05). Dialysis patients should be educated about the importance of preventive dental care. Medical providers are expected to participate in promoting dental visits among dialysis patients. (Tokushima University Institutional Repository) ● Metadata: 114500 (Link to Publication Site) ● Publication site (DOI): 10.5527/wjn.v5.i5.455 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27648409 ● Search Scopus @ Elsevier (PMID): 27648409 ● Search Scopus @ Elsevier (DOI): 10.5527/wjn.v5.i5.455 (Tokushima University Institutional Repository: 114500, DOI: 10.5527/wjn.v5.i5.455, PubMed: 27648409)
33.	Hiromi Nakae, Masami Yoshioka, 薮内さつき, Tokiko Doi, Natsumi Fujiwara, Hiroki Iga and Daisuke Hinode : Problems on oral healthcare in convalescent hospitals : Questionnaire survey for non-dental professionals, Oral Care, Vol.11, No.1, 30-34, 2016. (Keyword) 口腔ケア / 回復期病院 / 多職種連携 / oral healthcare / convalescent hospitals / collaboration among multi-professions (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522825130978137600 (CiNii: 1522825130978137600)
34.	池田真己, 井手口英章, Hiroki Iga, Daisuke Hinode and Fumiaki Kawano : Analysis of the educational effect of OSCE performed at the college of dental hygienist course, The Journal of Japan Society of Dental Hygiene Education, Vol.7, No.1, 73-82, 2016. (Keyword) 客観的臨床能力試験(OSCE) / 歯科衛生士教育 / 臨床実習評価 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1524232505875606784 (CiNii: 1524232505875606784)
35.	Harumi Sakamoto, Daisuke Hinode, 武川香織, 幸江真杉, 高橋侑子, Yuka Sogawa, 森山聡美, Tokiko Doi, Hiromi Nakae, Masaaki Yokoyama, Kanako Tamatani, Masami Yoshioka and Fumiaki Kawano : 妊娠期の歯周状態と低体重児出産のリスクに関する観察研究, Journal of Dental Health, Vol.66, No.3, 322-327, 2016. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.66.3_322 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205002852224 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.66.3_322 (DOI: 10.5834/jdh.66.3_322, CiNii: 1390001205002852224)
36.	Jade Fournier-Larente, Jabrane Azelmat, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : The Daiokanzoto (TJ-84) Kampo formulation reduces virulence factor gene expression in Porphyromonas gingivalis and possesses anti-inflammatory and anti-protease activities, PLoS ONE, Vol.11, No.2, e0148860, 2016. (Summary) Kampo formulations used in Japan to treat a wide variety of diseases and to promote health are composed of mixtures of crude extracts from the roots, bark, leaves, and rhizomes of a number of herbs. The present study was aimed at identifying the beneficial biological properties of Daiokanzoto (TJ-84), a Kampo formulation composed of crude extracts of Rhubarb rhizomes and Glycyrrhiza roots, with a view to using it as a potential treatment for periodontal disease. Daiokanzoto dose-dependently inhibited the expression of major Porphyromonas gingivalis virulence factors involved in host colonization and tissue destruction. More specifically, Daiokanzoto reduced the expression of the fimA, hagA, rgpA, and rgpB genes, as determined by quantitative real-time PCR. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to evaluate the anti-inflammatory properties of Daiokanzoto. Daiokanzoto attenuated the P. gingivalis-mediated activation of the NF-κB signaling pathway. It also reduced the secretion of pro-inflammatory cytokines (IL-6 and CXCL8) by lipopolysaccharide-stimulated oral epithelial cells and gingival fibroblasts. Lastly, Daiokanzoto, dose-dependently inhibited the catalytic activity of matrix metalloproteinases (-1 and -9). In conclusion, the present study provided evidence that Daiokanzoto shows potential for treating and/or preventing periodontal disease. The ability of this Kampo formulation to act on both bacterial pathogens and the host inflammatory response, the two etiological components of periodontal disease, is of high therapeutic interest. (Tokushima University Institutional Repository) ● Metadata: 112304 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0148860 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26859747 ● Search Scopus @ Elsevier (PMID): 26859747 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0148860 (Tokushima University Institutional Repository: 112304, DOI: 10.1371/journal.pone.0148860, PubMed: 26859747)
37.	Riko Kobayashi, Masami Yoshioka, Miwa Matsuyama and Daisuke Hinode : 大学歯学部生における口腔健康状態に対する意識および歯科保健行動, Journal of Shikoku Public Health Society, Vol.61, No.1, 81-85, 2016.
38.	Yumi Kuwamura, Sumikawa Masuko, Tetsuya Tanioka, Toshihiko Nagata, Eijiro Sakamoto, Hiromi Murata, Munehide Matsuhisa, Ken-ichi Aihara, Daisuke Hinode, Hirokazu Uemura, Hirokazu Ito, Yuko Yasuhara and Rozzano De Castro Locsin : Development of the Diabetes Oral Health Assessment Tool © for Nurses, Health, Vol.7, No.12, 1710-1720, 2015. (Keyword) diabetes mellitus / oral health behaviors / Oral Status / Nursing Assessment / Diabetes Nurse Specialist (Link to Publication Site) ● Publication site (DOI): 10.4236/health.2015.712186 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4236/health.2015.712186 (DOI: 10.4236/health.2015.712186)
39.	Masami Yoshioka, Yasuhiko Shirayama, Issei Imoto, Shizuko Yanagisawa and Daisuke Hinode : 歯科併設のない人工透析実施医療機関における医科歯科連携, Journal of Dental Health, Vol.65, No.4, 348-353, 2015. (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.65.4_348 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205002249216 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.65.4_348 (DOI: 10.5834/jdh.65.4_348, CiNii: 1390001205002249216)
40.	T Hanioka, M Ojima, Y Kawaguchi, Y Hirata, H Ogawa, Daisuke Hinode, N Hanada and E Inoshita : Education of tobacco use interventions for undergraduate dental students, Japanese Dental Science Review, Vol.51, No.3, 65-74, 2015. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jdsr.2015.03.003 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdsr.2015.03.003 (DOI: 10.1016/j.jdsr.2015.03.003)
41.	Masami Yoshioka, Yasuhiko Shirayama, Issei Imoto, Daisuke Hinode, Shizuko Yanagisawa and Yuko Takeuchi : Current status of collaborative relationships between dialysis facilities and dental facilities in Japan: results of a nationwide survey, BMC Nephrology, Vol.16, No.17, 2015. (Summary) Recent studies have reported an association between periodontal disease and mortality among dialysis patients. Therefore, preventive dental care should be considered very important for this population. In Japan, no systematic education has been undertaken regarding the importance of preventive dental care for hemodialysis patients--even though these individuals tend to have oral and dental problems. The aim of this study was to investigate the current state of collaborative relationships between hemodialysis facilities and dental services in Japan and also to identify strategies to encourage preventive dental visits among hemodialysis outpatients. A nationwide questionnaire on the collaborative relationship between dialysis facilities and dental facilities was sent by mail to all medical facilities in Japan offering outpatient hemodialysis treatment. Responses were obtained from 1414 of 4014 facilities (35.2%). Among the 1414 facilities, 272 (19.2%) had a dental service department. Approximately 100,000 dialysis outpatients were receiving treatment at these participating facilities, which amounts to one-third of all dialysis patients in Japan. Of those patients, 82.9% received hemodialysis at medical facilities without dental departments. Only 87 of 454 small clinics without in-house dental departments (19.2%) had collaborative registered dental clinics. Medical facilities with registered dental clinics demonstrated a significantly more proactive attitude to routine collaboration on dental matters than facilities lacking such clinics. Our nationwide survey revealed that most dialysis facilities in Japan have neither an in-house dental department nor a collaborative relationship with a registered dental clinic. Registration of dental clinics appears to promote collaboration with dental facilities on a routine basis, which would be beneficial for oral health management in hemodialysis patients. (Tokushima University Institutional Repository) ● Metadata: 114768 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12882-015-0001-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25880326 ● Summary page in Scopus @ Elsevier: 2-s2.0-84927755808 (Tokushima University Institutional Repository: 114768, DOI: 10.1186/s12882-015-0001-0, PubMed: 25880326, Elsevier: Scopus)
42.	Tokiko Doi, Hiromi Nakae, Daisuke Hinode, Masami Yoshioka and 隆仁米津 : 学校給食における残食の要因調査, Journal of Shikoku Public Health Society, Vol.60, No.1, 85-88, 2015.
43.	Kaya Yoshida, Masami Yoshioka, Hirohiko Okamura, Moriyama Satomi, Kazuyoshi Kawazoe, Grenier Daniel and Daisuke Hinode : Preventive effect of Daiokanzoto (TJ-84) on 5-fluorouracil-induced human gingival cell death through the inhibition of reactive oxygen species production, PLoS ONE, Vol.9, No.11, e112689, 2014. (Summary) Daiokanzoto (TJ-84) is a traditional Japanese herbal medicine (Kampo formulation). While many Kampo formulations have been reported to regulate inflammation and immune responses in oral mucosa, there is no evidence to show that TJ-84 has beneficial effects on oral mucositis, a disease resulting from increased cell death induced by chemotherapeutic agents such as 5-fluorouracil (5-FU). In order to develop effective new therapeutic strategies for treating oral mucositis, we investigated (i) the mechanisms by which 5-FU induces the death of human gingival cells and (ii) the effects of TJ-84 on biological events induced by 5-FU. 5-FU-induced lactate dehydrogenase (LDH) release and pore formation in gingival cells (Sa3 cell line) resulted in cell death. Incubating the cells with 5-FU increased the expression of nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) and caspase-1. The cleavage of caspase-1 was observed in 5-FU-treated cells, which was followed by an increased secretion of interleukin (IL)-1β. The inhibition of the NLRP3 pathway slightly decreased the effects of 5-FU on cell viability and LDH release, suggesting that NLRP3 may be in part involved in 5-FU-induced cell death. TJ-84 decreased 5-FU-induced LDH release and cell death and also significantly inhibited the depolarization of mitochondria and the up-regulation of 5-FU-induced reactive oxygen species (ROS) and nitric oxide (NO) production. The transcriptional factor, nuclear factor-κB (NF-κB) was not involved in the 5-FU-induced cell death in Sa3 cells. In conclusion, we provide evidence suggesting that the increase of ROS production in mitochondria, rather than NLRP3 activation, was considered to be associated with the cell death induced by 5-FU. The results also suggested that TJ-84 may attenuate 5-FU-induced cell death through the inhibition of mitochondrial ROS production. (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0112689 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25389767 ● Search Scopus @ Elsevier (PMID): 25389767 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0112689 (DOI: 10.1371/journal.pone.0112689, PubMed: 25389767)
44.	James Liao, Jabrane Azelmat, Lei Zhao, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : The Kampo medicine Rokumigan possesses antibiofilm, anti-inflammatory, and wound healing properties., BioMed Research International, Vol.2014, 436206, 2014. (Summary) Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss. The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different plants, for its capacity to prevent biofilm formation by Fusobacterium nucleatum, to inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion by mucosal cells, and to promote wound healing in a fibroblast model. Using a microplate colorimetric assay, Rokumigan prevented biofilm formation by F. nucleatum, while it had no effect on bacterial growth. Rokumigan inhibited IL-6 secretion in both epithelial cells and fibroblasts stimulated with lipopolysaccharide. However, it caused no significant inhibition of IL-8 secretion by both cell types. Rokumigan significantly increased proliferation and migration of gingival fibroblasts in a wound healing assay. In conclusion, the Kampo formulation Rokumigan, through suppression of biofilm formation by F. nucleatum, inhibition of IL-6 secretion by gingival epithelial cells and fibroblasts, and promotion of wound healing in a fibroblast model, may have potential application for periodontal diseases. (Keyword) Anti-Inflammatory Agents / Biofilms / Cell Line / Drugs, Chinese Herbal / Epithelial Cells / Fibroblasts / Fusobacterium nucleatum / Humans / Interleukin-6 / Interleukin-8 / Medicine, Kampo / Wound Healing (Link to Publication Site) ● Publication site (DOI): 10.1155/2014/436206 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24877093 ● Summary page in Scopus @ Elsevier: 2-s2.0-84901255883 (DOI: 10.1155/2014/436206, PubMed: 24877093, Elsevier: Scopus)
45.	S Tanabe, Masami Yoshioka, Daisuke Hinode and D Grenier : Subinhibitory concentrations of tetracyclines induce lipopolysaccharide shedding by Porphyromonas gingivalis and modulate the host inflammatory response., Journal of Periodontal Research, Vol.49, No.5, 603-608, 2013. (Summary) Antibiotics at below minimal inhibitory concentrations (MICs) may induce various biological responses in bacteria. In this study, we hypothesized that subinhibitory concentrations (subICs) of tetracycline and doxycycline induce the shedding of lipopolysaccharide (LPS) by Porphyromonas gingivalis and, as a consequence, may contribute to enhancing the host inflammatory response associated with periodontitis. (Link to Publication Site) ● Publication site (DOI): 10.1111/jre.12140 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24206088 ● Search Scopus @ Elsevier (PMID): 24206088 ● Search Scopus @ Elsevier (DOI): 10.1111/jre.12140 (DOI: 10.1111/jre.12140, PubMed: 24206088)
46.	James Liao, Lei Zhao, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : Effects of Japanese traditional herbal medicines (Kampo) on growth and virulence properties of Porphyromonas gingivalis and viability of oral epithelial cells., Pharmaceutical Biology, Vol.51, No.12, 1538-1544, 2013. (Summary) Kampos containing rhubarb and its anthraquinone derivatives may represent promising molecules for controlling periodontal diseases through their capacity to inhibit P. gingivalis growth and virulence properties. (Link to Publication Site) ● Publication site (DOI): 10.3109/13880209.2013.801995 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23987742 ● Search Scopus @ Elsevier (PMID): 23987742 ● Search Scopus @ Elsevier (DOI): 10.3109/13880209.2013.801995 (DOI: 10.3109/13880209.2013.801995, PubMed: 23987742)
47.	T Amou, Daisuke Hinode, Masami Yoshioka and D Grenier : Relationship between halitosis and periodontal disease - associated oral bacteria in tongue coatings., International Journal of Dental Hygiene, 2013. (Summary) These results suggested that periodontal disease-associated oral bacteria in TCs are closely related to halitosis and that tongue cleaning may be an effective method for improving halitosis. (Link to Publication Site) ● Publication site (DOI): 10.1111/idh.12046 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23890391 ● Search Scopus @ Elsevier (PMID): 23890391 ● Search Scopus @ Elsevier (DOI): 10.1111/idh.12046 (DOI: 10.1111/idh.12046, PubMed: 23890391)
48.	Hiromi Nakae, Daisuke Hinode, 薮内さつき, Masami Yoshioka, Hiroki Iga, Fumiaki Kawano and Katsuhiko Yoshimoto : The usefulness of the educational management network system for promoting "dental education program with community-rearing", The Journal of Japan Society of Dental Hygiene Education, Vol.4, No.1, 49-54, 2013. (Keyword) 地域育成型歯学教育 / 教育管理ネットワークシステム / 学外体験学習 / dental education program with community-rearing / the educational management network system / practice in off-campus experiential learning (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522262181041421824 (CiNii: 1522262181041421824)
49.	Masami Yoshioka, Daisuke Hinode, Masaaki Yokoyama, Aiichiro Fujiwara, Yasuhiko Sakaida and Kenji Toyoshima : Relationship between Subjective Oral Health Status and Lifestyle in Elderly People: A Cross-Sectional Study in Japan., ISRN Dentistry, Vol.2013, 2013. (Summary) Objective. The aim of this study was to assess the relationship between subjective oral health status and lifestyle in elderly people living in Japan. Methods. Subjects were 5383 inhabitants of the Kagawa Prefecture, Japan, at the age of 75-100. Records of the number of remaining teeth and the data from self-reported questionnaire were analyzed statistically. Results. Remaining teeth were significantly correlated to "no current smoking," while not related to other lifestyle. On the other hand, "subjective masticatory ability" defined as a condition allowing chewing all foods well was related to favorable lifestyles. "Subjective masticatory ability" was also related to "not feeling stress," "no deviated food habit" as well as to other good oral health conditions. A logistic regression analysis for "remaining teeth more than 20" revealed a significant relationship between "no current smoking" (OR = 1.582) and "no alcohol drinking" (OR = 0.851). Regarding "subjective masticatory ability," all favorable lifestyles analyzed in this study were found to be significant positive factors. Conclusions. "Subjective masticatory ability" seems to be strongly associated with favorable lifestyles. Therefore, it can be suggested that "subjective masticatory ability" might be a good landmark for quality of life of elderly people in addition to the number of remaining teeth. (Link to Publication Site) ● Publication site (DOI): 10.1155/2013/687139 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23738087 ● Search Scopus @ Elsevier (PMID): 23738087 ● Search Scopus @ Elsevier (DOI): 10.1155/2013/687139 (DOI: 10.1155/2013/687139, PubMed: 23738087)
50.	Masami Yoshioka, Daisuke Hinode, Yota Yamamoto, Yoshihito Furukita and Akira Tangoku : Alteration of the oral environment in patients undergoing esophagectomy during the perioperative period, Journal of Applied Oral Science, Vol.21, No.2, 183-189, 2013. (Summary) During the perioperative period, oral ingestion is changed considerably in esophagectomy patients. The aim of this study was to investigate oral environment modifications in patients undergoing esophageal cancer treatments due to changes in dietary intake and swallowing functions. Thirty patients who underwent operation for removal of esophageal cancer in Tokushima University Hospital were enrolled in this study. It was found that 1) the flow rate of resting saliva decreased significantly at postoperative period by deprived feeding for one week, although it did not recover several days after oral ingestion began, 2) the accumulation of dental plaque and the number of mutans streptococci in saliva decreased significantly after operation, while both increased relatively quick when oral ingestion began, and 3) the swallowing function decreased significantly in the postoperative period. These results suggest that dental professionals should emphasize the importance of oral health care and provide instructions on plaque control to patients during the perioperative period of esophageal cancer treatment. (Keyword) Aged / Aged, 80 and over / Deglutition / Dental Plaque / Eating / Esophageal Neoplasms / Esophagectomy / Female / Humans / Male / Middle Aged / Perioperative Period / Saliva / Salivation / Secretory Rate / Statistics, Nonparametric / Streptococcus mutans / Time Factors (Link to Publication Site) ● Publication site (DOI): 10.1590/1678-7757201302338 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23739864 ● Search Scopus @ Elsevier (PMID): 23739864 ● Search Scopus @ Elsevier (DOI): 10.1590/1678-7757201302338 (DOI: 10.1590/1678-7757201302338, PubMed: 23739864)
51.	Masami Yoshioka, Hiromi Nakae, 一宮斉子, 横山正明, 原田路可, Yasuhiko Shirayama, Fumiaki Kawano and Daisuke Hinode : 病院における専門的口腔ケアへの認知度と期待ー急性期脳卒中患者家族のアンケート調査よりー, Journal of Shikoku Public Health Society, Vol.58, No.1, 80-85, 2013.
52.	Masami Yoshioka, Hiromi Nakae, 一宮斉子, 天羽崇, 高橋侑子, Yuka Sogawa and Daisuke Hinode : Effect of Taking Supplementary Food for Swallowing on the Intraoral Food Residue, Journal of Dental Health, Vol.62, No.5, 454-460, 2012. (Keyword) 嚥下補助食品 / 口腔衛生状態 / 口腔内残留 / Supplementary food for swallowing / Oral hygiene / Intraoral residue (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679980261376 (CiNii: 1390282679980261376)
53.	Kaya Yoshida, Hirohiko Okamura, Kazuhiko Ochiai, Yumi Hoshimo, Tatsuji Haneji, Masami Yoshioka, Daisuke Hinode and Hideo Yoshida : PKR plays a positive role in osteoblast differentiation by regulating GSK-3b activity through a b-catenin-independent pathway, Molecular and Cellular Endocrinology, Vol.361, No.1-2, 99-105, 2012. (Summary) Double-stranded RNA-dependent protein kinase (PKR) is involved in various cellular functions. We previously reported that PKR regulates osteoblast differentiation, but the specific mechanisms by which this occurs remain unclear. In this study, we investigated the role of PKR in Glycogen synthase kinase 3 (GSK-3) regulation of osteoblast differentiation. Lithium chloride (LiCl), a GSK-3 inhibitor, increased GSK-3 phosphorylation in MC3T3-E1 and MG-63 cells. LiCl also inhibited Runx2 and expression of its regulated genes, causing inhibition of Alkaline phosphatase activity and mineralization. LiCl injection to the calvaria in mice suppressed bone formation. Further, GSK-3 phosphorylation was increased in osteoblasts, by Akt-independent mechanisms, in which PKR was constitutively inactivated. A PKR inhibitor, 2-aminopurine, also induced GSK-3 phosphorylation in MC3T3-E1 and MG-63 cells. Further, Runx2 and its regulated genes were inhibited in PKR-inactivated osteoblasts, and differentiation was suppressed through a -catenin-independent pathway. PKR positively regulates the differentiation of osteoblasts by mediating GSK-3 activity through a -catenin-independent pathway. (Keyword) Animals / Cell Differentiation / Cell Line / Enzyme Activation / Glycogen Synthase Kinase 3 / Humans / Lithium Chloride / Mice / Models, Biological / Osteoblasts / Osteogenesis / Phosphorylation / Proto-Oncogene Proteins c-akt / Signal Transduction / Skull / beta Catenin / eIF-2 Kinase (Link to Publication Site) ● Publication site (DOI): 10.1016/j.mce.2012.03.019 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22484461 ● Search Scopus @ Elsevier (PMID): 22484461 ● Search Scopus @ Elsevier (DOI): 10.1016/j.mce.2012.03.019 (DOI: 10.1016/j.mce.2012.03.019, PubMed: 22484461)
54.	Yuko Takeuchi, Yasuhiko Shirayama, Daisuke Hinode, Masami Yoshioka and 薮内さつき : Evaluation of collaborative learning program with aged people in dental hygienist education, Journal of Shikoku Public Health Society, Vol.57, No.1, 71-74, 2012.
55.	Kaya Yoshida, Hirohiko Okamura, Yumi Hoshimo, Masayuki Shono, Masami Yoshioka, Daisuke Hinode and Hideo Yoshida : Interaction between PKR and PACT mediated by LPS-inducible NF-kB in human gingival cells, Journal of Cellular Biochemistry, Vol.113, 165-173, 2012. (Summary) The double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine kinase expressed constitutively in mammalian cells. PKR is activated upon virus infection by double-stranded RNA (dsRNA), and plays a critical role in host antiviral defense mechanisms. PKR is also known to regulate various biological responses, including cell differentiation and apoptosis. However, whether PKR is involved in the progress of periodontitis is not clear. The present study explained the phosphorylation of PKR by LPS in the human gingival cell line, Sa3. Expression of genes encoding LPS receptors was detected in Sa3 cells and treatment of cells with 1 µg/mL LPS for 6 h caused PKR phosphorylation. LPS elevated the expression of the protein activator of PKR (PACT) mRNA and protein, followed by the enhanced association between PACT and PKR within 3 h. In addition, LPS treatment induced the translocation of NF-κB to the nucleus after 30 min, and inhibition of NF-κB decreased the PACT-PKR interaction induced by LPS. The level of pro-inflammatory cytokine mRNA, including interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα), appeared within 45 min and reached at the maximal levels by 90 min after the addition of LPS. This induction of pro-inflammatory cytokines was not affected by RNAi-mediated silencing of PKR and a pharmacological inhibitor of PKR, whereas the inhibition of NF-κB decreased it. These results indicated that LPS induces PKR phosphorylation and the PACT-PKR association in Sa3 cells. Our results also suggest that NF-κB is involved in the PACT-PKR interaction and the production of pro-inflammatory cytokines in periodontitis. (Keyword) Apoptosis / Biological Transport / Cell Line / Gingiva / Humans / Interleukin-6 / Lipopolysaccharides / NF-kappa B / Periodontitis / Phosphorylation / RNA Interference / RNA, Double-Stranded / RNA, Small Interfering / RNA-Binding Proteins / Signal Transduction / Tumor Necrosis Factor-alpha / eIF-2 Kinase (Link to Publication Site) ● Publication site (DOI): 10.1002/jcb.23340 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21882225 ● Search Scopus @ Elsevier (PMID): 21882225 ● Search Scopus @ Elsevier (DOI): 10.1002/jcb.23340 (DOI: 10.1002/jcb.23340, PubMed: 21882225)
56.	中江弘美, Daisuke Hinode, 薮内さつき, Yuko Takeuchi, Masami Yoshioka, Hiroki Iga, Masanori Nakano, Hideo Yoshida, Kazumi Ozaki, Masaru Hada, Fumiaki Kawano and Katsuhiko Yoshimoto : 地域高齢者との福祉体験学習の教育効果と地域貢献事業としての評価, Journal of University Education Research, Vol.8, 17-24, 2011. (Summary) The purose of this study is to evaluate the educational effect by the welfare-experience learning program with aged people in community，and to evaluate this program as the regional contribution. This program is to aim at having a consciousness of becoming the dental professional in the University of Tokushima，Faculty of Dentistry，and they were carried out with 16 institutions (a total of 28 times).This program makes students accompany the oral health guidance"long-life oral healthy classroom"，and they carried out the experience study as on auxiliary person of the variaus functional oral-training for elderly people.By the investigation of the student's report, there are students who recognized the achievement objectives which are roles of the way concerning regional contribution as dental professionals in community. On the other hand，the questionnaire to the participating persoonnel was conducted in order to evalaote this program as the regional contrtbution. As a result，this program is useful to elderly people and the understanding of institution personnel is also deepened this practice. As mentioned above，the result of having is suitable for the educational goal "to have a consciousness of becoming the dental professional". Furthermore，this program was considered that future continuation is also expected by deepening of an understanding to the personnel's functional oral-training program.本研究の目的は，地域高齢者との福祉体験学習における学生への教育効果と，地域貢献事業としての評価をすることである．徳島大学歯学部では，医療人を志すものとしての自覚を持つことを目的とした取り組みを県内16カ所の施設で合計28回実施した．これは，学生が口腔保健指導「お口の健康長寿教室」において，高齢者を対象とした口腔機能訓練の補助者として体験学習するものである．学習後のレポートから，到達目標とした地域貢献の在り方や歯科専門職としての役割を認識する学生が多くを占めた．一方，地域貢献事業として評価するため，参加職員への調査を行った結果，利用者への役立ちに加え，多くの施設職員の理解も深まったとのアンケート結果が得られた．以上から，本取り組みは学生への教育目標「医療人としての自覚を持つ」に沿った成果が得られており，また，施設職員の口腔機能向上プ口グラムへの盤解の深まりから，今後の継続が期待される． (Keyword) 体験学習 / タイケンガクシュウ / 教育効果 / キョウイクコウカ / 地域貢献 / チイキコウケン / experience learning / experience learning / regional contribution / regional contribution / educational effects / educational effects (Tokushima University Institutional Repository) ● Metadata: 82982 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287417217536 (Tokushima University Institutional Repository: 82982, CiNii: 1050564287417217536)
57.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Masami Yoshioka, Kosuke Kataoka and Hiro-O Ito : Levels of salivary stress markers in patients with anxiety about halitosis, Archives of Oral Biology, Vol.55, No.11, 842-847, 2010. (Summary) To investigate the relationship between salivary stress markers and mental stress states in patients complaining of oral malodour. The utility of the salivary stress markers in assessment of mental conditions of those patients was also investigated. The study population included 74 patients, aged 20-59 years, who complained of oral malodour and were referred to the Breath Odor Clinic at Tokushima University Hospital. Patients were classified into two groups, genuine halitosis (GH) and psychosomatic halitosis (PH), according to the results of organoleptic rating measurement. All patients were subjected to examination by the Cornell Medical Index (CMI) Health Questionnaire. Resting saliva was collected and levels of salivary IgA, cortisol and chromogranin A were determined by ELISA. Twenty-three volunteers not complaining of halitosis were included as the control group. Kruskal-Wallis test and Mann-Whitney's U-test were used for statistical analysis. A significant increase was observed in the concentrations of salivary cortisol in the PH group as compared with GH and control groups (p<0.05). Concentrations of IgA and chromogranin A in saliva were not significantly different among the three groups. In addition, higher salivary cortisol concentrations were found in CMI scale III and IV (tendency towards neurosis) than in scale I and II (normal) (p<0.05). Since salivary cortisol reflects a status of chronic stress condition, psychosomatic halitosis might be closely related to this state of chronic stress. Determination of cortisol levels in saliva may provide useful information for evaluating the mental status of patients complaining of halitosis. (Keyword) Adult / Anxiety / Biological Markers / Case-Control Studies / Chromogranin A / Enzyme-Linked Immunosorbent Assay / Female / Halitosis / Humans / Hydrocortisone / Immunoglobulin A / Male / Middle Aged / Psychophysiologic Disorders / Questionnaires / Saliva / Statistics, Nonparametric (Link to Publication Site) ● Publication site (DOI): 10.1016/j.archoralbio.2010.07.014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20807658 ● Search Scopus @ Elsevier (PMID): 20807658 ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2010.07.014 (DOI: 10.1016/j.archoralbio.2010.07.014, PubMed: 20807658)
58.	Yuka Sogawa, Masaaki Yokoyama, Harumi Sakamoto, 幸江真杉, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : The study of oral health promotion for pregnant women at Tokushima University Hospital, The Journal of Japan Society for Dental Hygiene, Vol.4, No.1, 50-57, 2009. (Keyword) 歯周疾患指数 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521699231068868224 (CiNii: 1521699231068868224)
59.	Masaaki Yokoyama, 隆仁米津, 正秋横山, 聡安達, 通仁久米, 明人和田, Masami Yoshioka and Daisuke Hinode : 徳島県における妊婦歯科健診受診者の口腔保健の現状および低体重児出産との関連性, Journal of Dental Health, Vol.59, No.3, 190-197, 2009. (Summary) Recent studies have suggested that periodontal diseases in pregnant women may be a significant risk factor for low-birth-weight deliveries (less than 2,500g). The aim of this study was to investigate the relationships between the oral health condition, health behavior of pregnant women, and low-birth-weight outcome. We performed oral examinations and conducted a survey of pregnant women to investigate their oral health status and behavior in Tokushima Prefecture. Among 739 pregnant women that received oral examinations, 454 (61.4%) reported complaints and inconvenience related to their oral cavities, 380 women (51.4%) reported gingival bleeding on brushing, while 406 women (54.9%) had teeth which needed treatment. Three hundred and one women (40.7%) harbored periodontal pockets with a depth ≥4mm, and were assigned a Community Periodontal Index (CPI) code of 3 or 4. On the other hand, there were only 136 women (18.4%) who received regular dental checkups. The percentage of pregnant women with a CPI of 3 or 4 was higher than that of women in the same age group based on the Comprehensive Guide to the Survey of Dental Diseases (2005). The percentage of subjects with a CPI of 3 or 4 among pregnant women with a smoking habit was higher than in a group of non-smoking pregnant women (p<0.05). All pregnant women with a smoking habit had a CPI≥1. In addition, we examined the relationship between the oral health status of the pregnant women and a low-birth-weight outcome. Stepwise logistic regression analysis of the 227 pregnant women who signed the informed consent document for this study showed that a smoking habit (OR 5.96, 95% CI 1.16-30.53, p=0.03) and periodontal pocket depth ≥4mm (OR 3.34, 95% CI 1.18-9.42, p=0.02) were significantly associated with low-birth-weight deliveries. In conclusion, efforts should be made to motivate pregnant women to undergo regular dental checkups for periodontal disease prevention and quit smoking. (Keyword) 歯周疾患指数 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205004298368 (CiNii: 1390001205004298368)
60.	Kaya Yoshida, Hirohiko Okamura, Bruna Rabelo Amorim, Daisuke Hinode, Hideo Yoshida and Tatsuji Haneji : PKR-mediated degradation of STAT1 regulates osteoblast differentiation, Experimental Cell Research, Vol.315, No.12, 2105-2114, 2009. (Summary) The double-stranded RNA-dependent protein kinase (PKR) plays a critical role in various biological responses including antiviral defense, cell differentiation, apoptosis, and tumorigenesis. In this study, we investigated whether PKR could affect the post-translational modifications of STAT1 protein and whether these modifications regulate osteoblast differentiation. We demonstrated that PKR was necessary for the ubiquitination of STAT1 protein. The expressions of bone-related genes such as type I collagen, integrin binding sialoprotein, osteopontin, and osterix were suppressed in osteoblasts lacking PKR activity. In contrast, the expressions of interleukin-6 and matrix metalloproteinases 8 and 13 increased in PKR-mutated osteoblasts. The expression and degradation of STAT1 protein were regulated by PKR in a SLIM-dependent pathway. Inhibition of SLIM by RNA interference resulted in the decreased activity of Runx2 in osteoblasts. Stimulation of interleukin-6 expression and suppression of alkaline phosphatase activity were regulated through by SLIM-dependent pathway. However, expressions of bone-related genes and MMPs were regulated by SLIM-independent pathway. Our present results suggest that the aberrant accumulation of STAT1 protein induced by loss of PKR regulate osteoblast differentiation through both SLIM/STAT1-dependent and -independent pathways. (Keyword) Adaptor Proteins, Signal Transducing / Alkaline Phosphatase / Animals / Antigens, Differentiation / Cell Differentiation / Cell Line / Interleukin-6 / LIM Domain Proteins / Metalloproteases / Mice / Osteoblasts / RNA, Messenger / STAT1 Transcription Factor / Ubiquitin-Protein Ligases / Ubiquitination / eIF-2 Kinase (Link to Publication Site) ● Publication site (DOI): 10.1016/j.yexcr.2009.02.003 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19230833 ● Search Scopus @ Elsevier (PMID): 19230833 ● Search Scopus @ Elsevier (DOI): 10.1016/j.yexcr.2009.02.003 (DOI: 10.1016/j.yexcr.2009.02.003, PubMed: 19230833)
61.	Hiroki Iga, Daisuke Hinode, Masanori Nakano, Hideo Yoshida, Kazumi Ozaki, Masaru Hada, Masami Yoshioka, Kaya Yoshida, Yuko Takeuchi, Yumi Hoshimo, Naoko Matsumoto and Toshihiko Nagata : 徳島大学パイロット事業支援プログラム「歯科医療系学生の口腔保健・福祉体験実習による健康長寿支援」, Journal of University Education Research, Vol.6, 108-114, 2009. (Keyword) 口腔保健福祉 / コウクウホケンフクシ / 健康長寿支援 / ケンコウチョウジュシエン / ホスピタリティマインド / ホスピタリティマインド / oral health and welfare / oral health and welfare / health support program / health support program / hospitality mind / hospitality mind (Tokushima University Institutional Repository) ● Metadata: 82696 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812440496128 (Tokushima University Institutional Repository: 82696, CiNii: 1050282812440496128)
62.	Daisuke Hinode, Hiroki Iga, Masanori Nakano, Fumiaki Kawano and Katsuhiko Yoshimoto : 教育GP「高齢社会を担う地域育成型歯学教育」(第1報) 高齢者交流学習による教育効果, Shikoku Dental Research, Vol.22, No.1, 129-131, 2009. (Summary) 歯学部1年生22名(口腔保健学科16名，歯学科6名)を対象に，平成20年度に実施した高齢者交流学習の教育効果について考察した．交流前には同施設長より生と死，老いについて特別講義を受け，4回目の交流後及び最終回の交流後にふり返り授業を実施した．交流学習の教育効果については毎回の学習記録と共に自己評価を10点満点で記載させた．養護老人ホームにおいて高齢者との1対1の交流からコミュニケーションを養う交流学習を実施した結果，交流後の学習記録に認められる心に深く感じた内容や自己評価点数の上昇，更に四つの到達目標に沿った表現の記載が参加学生から認められたことから，1年次に実施した取り組みは人間力の向上という一般目標に適した有効な教育カリキュラムであると思われた． (Keyword) 歯科学生カリキュラム教育測定コミュニケーション医療従事者-患者関係地域社会歯科学特別養護老人ホーム高齢者歯科医療歯学大学教育高齢化社会ヒト成人(19~44) 歯学 (Tokushima University Institutional Repository) ● Metadata: 109789 (Tokushima University Institutional Repository: 109789)
63.	Masami Yoshioka, 裕美藤井, 廣瀬薫, Harumi Sakamoto, Yuka Sogawa, Naoko Matsumoto, Yumi Hoshimo, Makoto Fukui, Masaaki Yokoyama and Daisuke Hinode : 急性期病院の脳神経疾患患者に対する口腔ケアニーズの分析, Journal of Dental Health, Vol.58, No.5, 490-497, 2008. (Summary) The purpose of the present study was to identify factors related to oral health care among inpatients with neurological disorders. For each of the 143 inpatients included in our study, the oral as well as general health (level of consciousness, feeding style, etc.) conditions were investigated using an assessment sheet at their first visit. The study revealed that 80% of the hospitalized patients showed "dysfunction of oral periphery muscle and/or tongue movement", 60% of them presented "dry mouth" and/or a "reduced level of consciousness", and 25% exhibited "constant open mouth with no intention". By logistic regression analysis of the data, it was strongly suggested that "severe debris accumulation" could be attributed to "dry mouth". Furthermore, "dry mouth" was found to be significantly correlated with several features, including "constant open mouth", "impaired mouth rinse", "dysfunction of oral periphery muscle and/or tongue movement", and "reduced level of consciousness", which are conditions often observed in patients with neurological disorders. These results suggest that inpatients with both a "reduced level of consciousness" and "constant open mouth" should receive professional oral care in order to prevent "dry mouth", and undergo a careful follow-up to promote the maintenance of good oral hygiene and functions. (Keyword) 専門的口腔ケア / 脳神経疾患 / 口腔乾燥 / 口腔衛生状態 / 急性期 / Professional oral care / Neurological disorders / Dry mouth / Oral hygiene condition / Acute phase (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205004141952 (CiNii: 1390001205004141952)
64.	Masaaki Yokoyama, Daisuke Hinode, Masami Yoshioka, Makoto Fukui, Shin-ichi Tanabe, Daniel Grenier and Hiro-O Ito : Relationship between Campylobacter rectus and periodontal status during pregnancy., Oral Microbiology and Immunology, Vol.23, No.1, 55-59, 2008. (Summary) In a previous study, we showed that the growth of Campylobacter rectus is stimulated by the presence of female sex hormones in the culture medium. In the present study, we examined the relationship between C. rectus levels in the saliva and the periodontal status of pregnant women. Unstimulated whole saliva was collected from 22 pregnant and 15 non-pregnant women. Periodontal pocket depth (PD) and bleeding on probing (BOP) were recorded. A quantitative real-time polymerase chain reaction was performed to determine the concentrations of suspected periodontopathogenic bacteria in the saliva samples. In addition, the concentration of estradiol in the saliva samples was measured by enzyme immunoassay. The average age, number of teeth, and total number of bacteria in the saliva of subjects in both groups were similar. The percentage of sites with a PD = 4 mm and the salivary estradiol concentrations were significantly higher in pregnant women than in non-pregnant women. In addition, the percentage of BOP sites and the C. rectus levels in the saliva of the pregnant women tended to be higher than in non-pregnant women, although these differences were not statistically significant. There were positive correlations between C. rectus levels and estradiol concentrations, and between C. rectus levels and the percentage of sites with PD = 4 mm in the pregnant women. These results indicate that C. rectus levels are higher in the oral flora of pregnant women and that this may be associated with increased salivary estradiol concentrations. This may contribute to periodontal disease progression during pregnancy. (Keyword) Actinobacillus actinomycetemcomitans / Adult / Age Factors / Campylobacter rectus / Colony Count, Microbial / Dentition / Estradiol / Estrogens / Female / Fusobacterium nucleatum / Gingival Hemorrhage / Humans / Periodontal Index / Periodontal Pocket / Porphyromonas gingivalis / Pregnancy / Pregnancy Complications / Prevotella intermedia / Saliva (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1399-302X.2007.00391.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18173799 ● Search Scopus @ Elsevier (PMID): 18173799 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1399-302X.2007.00391.x (DOI: 10.1111/j.1399-302X.2007.00391.x, PubMed: 18173799)
65.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Shin-ichi Tanabe and Masami Yoshioka : Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role., Oral Microbiology and Immunology, Vol.21, No.5, 289-295, 2006. (Summary) The aim of this study was to identify salivary immunoglobulin A (IgA) directed to oral microbial GroEL in patients with periodontitis and to demonstrate their potential protective role through a reduction of inflammatory cytokine production induced by microbial GroEL. Using five different proteins belonging to the heat-shock protein 60 family, Western immunoblot analysis of salivary IgA from 63 subjects revealed immunoreactivities with Campylobacter rectus GroEL and Porphyromonas gingivalis GroEL in subjects with periodontitis (P < 0.05) compared to control subjects. Using the BIACORE 1000 to measure the salivary IgA titers directed towards C. rectus GroEL, high resonance unit (RU) values were observed in the saliva samples from patients with periodontitis (P < 0.01). Furthermore, the number of teeth with deep pocket depth (>or=5 mm) showed a high correlation coefficient with the RU value (r = 0.50, P < 0.01). C. rectus GroEL possessed the ability to stimulate the production of interleukin-6 by gingival fibroblasts. Interestingly, salivary IgA antibody directed to C. rectus GroEL caused a partial inhibition of interleukin-6 production. This study showed a relationship between high levels of salivary IgA directed to GroEL and periodontal disease severity. Although additional investigations are required, salivary IgA to GroEL may have a protective role by reducing the inflammatory response induced by GroEL derived from periodontopathogenic bacteria. (Keyword) Adult / Antigen-Antibody Reactions / Antigens, Bacterial / Blotting, Western / Campylobacter rectus / Case-Control Studies / Chaperonin 60 / Female / Humans / Immunoglobulin A, Secretory / Interleukin-6 / Male / Middle Aged / Periodontitis / Saliva / Salivary Proteins and Peptides / Statistics, Nonparametric (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1399-302X.2006.00290.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16922927 ● Search Scopus @ Elsevier (PMID): 16922927 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1399-302X.2006.00290.x (DOI: 10.1111/j.1399-302X.2006.00290.x, PubMed: 16922927)
66.	Fumiko Michishige, Kyoko Kanno, Sumiko Yoshinaga, Daisuke Hinode, Takehisa Yozo and Yasuoka Susumu : Effect of saliva collection method on the concentration of protein components in saliva, The Journal of Medical Investigation : JMI, Vol.53, No.1,2, 140-146, 2006. (Summary) In order to clarify how we collect saliva for analyzing salivary protein in aged subjects who can not eat well, we compared the effects of suction, spitting and the swab saliva collection method on the yield of protein components in saliva samples from normal volunteers. The saliva collected by suction, spitting and the swab method were designated as, Saliva I, II and III, respectively. The saliva volume collected by Saliva I was about 2-fold greater than that by of Saliva II and III. This is mainly due to the fact that saliva secretion was stimulated by the suction itself. The content of total protein, S-IgA, trypsin-like activity and human airway trypsin-like protease (HAT) were almost the same in Saliva I and II, and significantly lower in Saliva III than in Saliva I and II. Kallikrein activity was almost the same in Saliva I, II and III. The concentration of each total protein, S-IgA, kallikrein activity, trypsin activity and HAT in Saliva I were significantly positively correlated with that in Saliva II. These results indicate that we can obtain information of change of salivary protein by analyzing saliva collected by suction method, although this method caused the stimulation of saliva to some extent. (Keyword) Adult / Female / Humans / Immunoglobulin A, Secretory / Kallikreins / Saliva / Salivary Proteins and Peptides / Serine Endopeptidases / Specimen Handling / Suction / Trypsin (Tokushima University Institutional Repository) ● Metadata: 110799 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.53.140 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16538007 ● Search Scopus @ Elsevier (PMID): 16538007 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.53.140 (Tokushima University Institutional Repository: 110799, DOI: 10.2152/jmi.53.140, PubMed: 16538007)
67.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura : The Effects of Supervised Fluoride Mouth Rinsing on Dental Caries Development : Analyses of Caries Development by Tooth Type and of the Relationship between Deciduous Tooth Caries and Permanent Tooth Caries, Journal of Dental Health, Vol.55, No.5, 552-558, 2005. (Summary) In 1993, a daily fluoride mouth rinsing program and biannual oral examination were started at the nursery school, elementary school and junior high school of the K District, Tokushima Prefecture. In this study, the longitudinal change of caries development in elementary school students was evaluated. Caries development by tooth type in schoolchildren of the 6th grade was evaluated, and furthermore, the relationship between deciduous tooth caries in 1st grade students and caries development in permanent teeth in 6th grade students was also elucidated. After starting the daily fluoride mouth rinsing program, caries development in the permanent teeth of the low grade children of the elementary school began to decrease first, followed by that of the high grade children, and then, the junior high school students. It was revealed that the strong suppression of caries development in the 1st molar was reflected in a decrease in total caries development in the 6th grade schoolchildren. In addition, a significant relationship between DMFT in the 6th grade schoolchildren and the number of deciduous tooth caries or the number of deciduous teeth in the 1st grade schoolchildren was detected. These results suggest that a fluoride mouth rinsing program before school age is effective for caries prevention in the 1st molar, but, in order to effectively prevent permanent tooth caries, a high risk strategy is needed for children with deciduous tooth caries. (Keyword) Supervised fluoride mouth rinsing / Caries prevention / Analysis by tooth type / The relationship of the deciduous teeth caries to the permanent teeth caries (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.55.5_552 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205003730816 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.55.5_552 (DOI: 10.5834/jdh.55.5_552, CiNii: 1390001205003730816)
68.	Masaaki Yokoyama, Daisuke Hinode, Kaname Masuda, Masami Yoshioka and Daniel Grenier : Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts, Oral Microbiology and Immunology, Vol.20, No.4, 239-243, 2005. (Summary) Recent studies have suggested a relationship between maternal Campylobacter rectus infections and preterm low birth weight. The purpose of this study was to investigate the effect of female sex hormones, estradiol and progesterone, on C. rectus and human gingival fibroblasts (HGF). The growth of C. rectus was significantly enhanced by incorporating either estradiol or progesterone in the culture medium. The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. In addition, a significantly higher secretion of VEGF by HGF treated with the combination of C. rectus and estradiol was observed in comparison with a treatment with C. rectus alone. Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose-dependent manner. The capacity of female sex hormones to enhance both C. rectus growth and VEGF, IL-6, and IL-8 production by HGF has the potential to contribute to periodontal disease progression during pregnancy. (Keyword) Campylobacter rectus / female sex hormones / human gingival fibroblasts / vascular endothelial growth factor (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1399-302X.2005.00222.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15943769 ● Search Scopus @ Elsevier (PMID): 15943769 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1399-302X.2005.00222.x (DOI: 10.1111/j.1399-302X.2005.00222.x, PubMed: 15943769)
69.	Youji Miyamoto, Kenji Fujisawa, 福田雅幸, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : 即時荷重インプラントに関する臨床的検討: 臨床術式と1年経過時の臨床成績, Journal of Japanese Society of Oral Implantology, Vol.18, No.2, 292-301, 2005. (Keyword) dental implant / early loading / immediate loading / load (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571135650275179904 (CiNii: 1571135650275179904)
70.	Youji Miyamoto, Kenji Fujisawa, Masayuki Fukuda, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : Clinical Examination of Immediate Loading Implants, --- Procedure and 1-year Clinical Results ---, Journal of Japanese Society of Oral Implantology, Vol.18, No.2, 78-292-87-301, 2005. (Keyword) dental implant / early louding / immediate loading / load
71.	Masami Yoshioka, Nozomi Yokoyama, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani and Daisuke Hinode : 官能試験の結果および質問票による口臭患者の分析, Journal of Dental Health, Vol.55, No.2, 83-88, 2005. (Summary) The aim of this study is to analyze the characteristics of patients suffering from malodor using organoleptic rating and questionnaires. Patients who were examined for halitosis at the Clinic of Preventive Dentistry, Tokushima University Medical and Dental Hospital, were classified into 4 groups based on the results of organoleptic measurement using plastic air bag. Aa group; obvious malodor beyond a socially acceptable level is neither perceived by dentists nor the patient. Ab group; obvious malodor is not perceived by dentists, although the patient complains of its existence. Ba group; obvious malodor is perceived by dentists only. Bb group; obvious malodor is perceived by both dentists and the patient. The profile of the Cornell Medical Index (CMI) Health Questionnaire and the questionnaire about a general attitudes toward halitosis were analyzed in each category. Patients in Ab group, who are supposed to have psychosomatic halitosis, showed a stronger tendency toward neurosis. More patients in the Ab group responded in the questionnaire that "I'm always anxious about malodor", and that "I feel malodor stronger than before", than in the other groups. Furthermore, patients in Aa and Ab group seemed to be interested in oral hygiene since many patients in these groups habitually used inter-dental brushing instruments daily. These results suggest that the sell-evaluation of breath by patients might provide useful information about the psychological conditions of patients. (Keyword) 口臭 / 官能試験 / 質問票 / 心因性口臭症 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679980640640 (CiNii: 1390282679980640640)
72.	Sumie Okamura, Daisuke Hinode, Hideki Nagata and Kazuo Kondo : The effects of vitamin C and E intake on blood antioxidative activity in smokers, Journal of Japan Society of Health Sciences, Vol.21, No.1, 105-114, 2005. (Keyword) smoker / Vitamin C / Vitamin E / lipid peroxide / TBARS (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571980075487113600 (CiNii: 1571980075487113600)
73.	Youji Miyamoto, Kenji Fujisawa, Takashi Sumitomo, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : Effect of Surface Topography on Ssseointegration Establishment of Dental Implant, --- Comparison between Smooth and Rough Surfaces ---, Journal of Japanese Society of Oral Implantology, Vol.17, No.2, 216-226, 2004. (Keyword) dental implant / early failure / osseointegration / prognosis / surface roughness (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680487133824 (CiNii: 1390282680487133824)
74.	Masami Yoshioka, Grenier Daniel, Daisuke Hinode, Makoto Fukui and Mayrand Denis : Antigenic cross-reactivity and sequence homology between Actinobacillus actinomycetemcomitans GroEL protein and human fibronectin, Oral Microbiology and Immunology, Vol.19, No.2, 124-128, 2004. (Summary) The immunologic cross-reactivity between human fibronectin and Actinobacillus actinomycetemcomitans GroEL was examined. Analyses by SDS-PAGE/Western immunoblotting and ELISA showed that a polyclonal antibody directed against the purified GroEL protein of A. actinomycetemcomitans, but not against the Escherichia coli GroEL, cross-reacts with human fibronectin. No antigenic cross-reactivity was observed between anti-A. actinomycetemcomitans GroEL antibody and type IV collagen, another important constituent of the basement membrane. A comparative analysis of the amino acid sequences of A. actinomycetemcomitans GroEL and human fibronectin revealed eight instances of four-amino acid sequence homology between the two proteins. Six of these tetrapeptide sequences were also shared with E. coli GroEL, suggesting that the remaining two tetrapeptides, GQLI (Glycine-Glutamine-Leucine-Isoleucine) and TGLE (Threonine-Glycine-Leucine-Glutamic acid), may be associated with the epitope that the anti-A. actinomycetemcomitans GroEL antibody specifically recognizes. Reactivity between TGLE, but not GQLI, with anti-A. actinomycetemcomitans GroEL antibody was confirmed by a biospecific interaction analysis using a biosensor technology. Although additional investigations are required, the observed phenomenon may lead to an autoimmune response and thus contribute to tissue destruction during periodontitis. (Keyword) Actinobacillus actinomycetemcomitans / fibronectin / GroEL / heat shock protein / periodontitis (Link to Publication Site) ● Publication site (DOI): 10.1111/j.0902-0055.2003.00125.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14871354 ● Search Scopus @ Elsevier (PMID): 14871354 ● Search Scopus @ Elsevier (DOI): 10.1111/j.0902-0055.2003.00125.x (DOI: 10.1111/j.0902-0055.2003.00125.x, PubMed: 14871354)
75.	Daisuke Hinode, Makoto Fukui, Nozomi Yokoyama, Masaaki Yokoyama, Masami Yoshioka and Ryo Nakamura : Relationship between tongue coating and secretory-immunoglobulin A level in saliva obtained from patients complaining of oral malodor, Journal of Clinical Periodontology, Vol.30, No.12, 1017-1023, 2003. (Summary) The aim of this study was to confirm the relationships between oral malodor and periodontal condition, oral malodor and tongue coating, and to investigate the secretory-immunoglobulin A (S-IgA) level in saliva in relation to the accumulation of tongue coating. Fifty-four patients complaining of oral malodor were included in the study. Their periodontal conditions, tongue coating status and salivary characteristics (flow rate, protein and S-IgA concentrations) were assessed in addition to the level of volatile sulfur compounds (VSC) in oral cavity. The patients were divided into three groups according to their tongue coating level. There are significant relationships between oral malodor and specific periodontal parameters used. The degree of tongue coating was also significantly correlated with the amount of H2S, CH3SH and the total amount of VSC determined. The concentration of S-IgA in the group identified as slight tongue coating was significantly higher than in the moderate or the severe group. By Western immunoblotting analysis, a high level of S-IgA specific to Streptococcus species was recognized in all groups, whereas the reactivity of Porphyromonas gingivalis and Fusobacterium nucleatum with S-IgA was very weak in both the slight and the moderate groups. Data herein indicate that tongue coating is closely related to oral malodor. Furthermore, S-IgA in saliva may influence the accumulation of tongue coating, and S-IgA antibodies directed to Streptococcus species may play a role in protective immunity against the initial colonization of tongue plaque. (Keyword) oral malodor / saliva / secretory-IgA / tongue coating (Link to Publication Site) ● Publication site (DOI): 10.1046/j.0303-6979.2003.00407.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15002886 ● Search Scopus @ Elsevier (PMID): 15002886 ● Search Scopus @ Elsevier (DOI): 10.1046/j.0303-6979.2003.00407.x (DOI: 10.1046/j.0303-6979.2003.00407.x, PubMed: 15002886)
76.	Hideki Nagata, Miki Ojima, Satoshi Shizukuishi, Akane Takemura, Daisuke Hinode, Makoto Fukui and Ryo Nakamura : Effect of vitamin C and vitamin E supplement on periodontal disease in smokers, Journal of Dental Health, Vol.53, No.5, 544-553, 2003. (Summary) Smoking habit has been reported as a risk factor for periodontal disease and low vitamin C intake has been associated with periodontal status. In this randomized controlled trial, we investigated the efficacy of dietary supplementation with antioxidative vitamins, vitamins C and E, on suppression of the progression of periodontal disease in smokers. A total of 65 patients who were current smokers were randomly assigned to one of the following groups : 1) VC (1,000 mg/day) ; 2) VE (135 mg/day) ; 3) combination of VC and VE ; 4) placebo. Plaque index (PI), clinical attachment level (CAL), pocket depth (PD) and cross-linked carboxyterminal telopeptide of type I collagen (I CTP) from gingival crevicular fluid (GCF) as a biomarker of periodontal disease, were measured at baseline, 12 and 24 weeks following the start of supplementation. CAL and PD in VC, VE and the combination groups showed significant improvements during this trial comparing with the placebo group (p<0.05). Furthermore, in the combination group, the rate of GCF samples in which I CTP was decreased or maintained was significantly greater than that in the placebo group at 24 weeks (p<0.05). On the other hand, VC levels in blood samples from VC and the combination groups (p<0.01) and VE levels from VE and the combination groups significantly rose from each level at baseline (p<0.05). These results suggest that supplements of VC and VE may maintain the periodontal health status in smokers by controlling oxidative status and other mechanisms. (Keyword) Risk factor for periodontal disease / Smoking habit / Vitamin C / Vitamin E / Randomized controlled trial (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205004003072 (CiNii: 1390001205004003072)
77.	Masami Yoshioka, Nozomi Yokoyama, Kaname Masuda, Honna Tomoaki, Daisuke Hinode, Ryo Nakamura, Rouabhia Mahmoud, Mayrand Denis and Grenier Daniel : Effect of hydroxamic acid-based MMP inhibitors on human gingival cells and Porphyromonas gingivalis, Journal of Periodontology, Vol.74, No.8, 1219-1224, 2003. (Summary) Matrix metalloproteinases (MMPs) are considered to play key roles in tissue destruction during periodontitis. In this study, we evaluated the cytotoxicity of hydroxamic acid-based MMP inhibitors (ONO-4817, ONO-MI1-514, and ONO-MI1-570), and their inhibitory effects on MMP-2 and -9 activities and growth of Porphyromonas gingivalis. Human gingival fibroblasts (HGF) and human gingival epithelial cells (HGE) were incubated with test inhibitors prior to investigating cell viability, cell proliferation, and mRNA expression for MMP-2 and -9. Gelatin zymography and a colorimetric MMP assay were performed to study the inhibitory effects on MMP-2 and -9 activities derived from HGF and HGE, respectively. The effect of MMP inhibitors on keratinocyte migration and P. gingivalis growth was also tested. Cell viability was not affected by any of the inhibitors at a final concentration of 50 microM, nor was cell proliferation at 20 microM. All inhibitors clearly inhibited MMP-2 produced by HGF and MMP-9 produced by HGE in a dose-dependent manner. No change was found in mRNA expression of MMPs by gingival cells treated with the inhibitors. ONO-4817 and ONO-MI1-514 inhibited keratinocyte migration. ONO-4817 showed a slightly inhibitory effect on the growth of P. gingivalis. Data obtained in this study support the potential use of the three MMP inhibitors for the prevention and treatment of periodontal disease. (Keyword) cells / gingival epithelial / cytotoxicity / fibroblasts / gingival / hydroxamic acids / metalloproteinase tissue inhibitors / matrix / metalloproteinases / Porphyromonas gingivalis (Link to Publication Site) ● Publication site (DOI): 10.1902/jop.2003.74.8.1219 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14514237 ● Search Scopus @ Elsevier (PMID): 14514237 ● Search Scopus @ Elsevier (DOI): 10.1902/jop.2003.74.8.1219 (DOI: 10.1902/jop.2003.74.8.1219, PubMed: 14514237)
78.	Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Yukihiro Momota, Masaru Nagayama, Eiji Yamauchi, Eiichi Bando and Daisuke Hinode : Evaluation of Risk Factors Concerning Loss of Osseointegration of Dental Implant, Journal of Japanese Society of Oral Implantology, Vol.16, No.2, 278-288, 2003. (Keyword) dental implant / late failure / osseointegration / clinical factor / risk factor (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205509924608 (CiNii: 1390001205509924608)
79.	Shin-ichi Tanabe, Daisuke Hinode, Masaaki Yokoyama, Makoto Fukui, Ryo Nakamura, Masami Yoshioka, Daniel Grenier and Denis Mayrand : Helicobacter pylori and Campylobacter rectus share a common antigen, Oral Microbiology and Immunology, Vol.18, No.2, 79-87, 2003. (Link to Publication Site) ● Publication site (DOI): 10.1034/j.1399-302X.2003.00049.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12654095 ● Search Scopus @ Elsevier (PMID): 12654095 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1399-302X.2003.00049.x (DOI: 10.1034/j.1399-302X.2003.00049.x, PubMed: 12654095)
80.	Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Masaru Nagayama, Eiji Yamauchi, Eiichi Bando and Daisuke Hinode : Evaluation of Clinical Factors Conserning Osseointegration Establishment of a Dental Implant, Journal of Japanese Society of Oral Implantology, Vol.15, No.4, 436-445, 2002. (Keyword) dental implant / early failure / osseointegration / clinical factor (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680486990592 (CiNii: 1390282680486990592)
81.	Kaname Masuda, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis, Infection and Immunity, Vol.70, No.4, 1807-1815, 2002. (Summary) Arginine carboxypeptidase was isolated from the cytoplasm of Porphyromonas gingivalis 381 and purified by DEAE-Sephacel column chromatography, followed by high-performance liquid chromatography on DEAE-5PW and TSK G2000SW(XL). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified enzyme revealed the presence of three major bands at 42, 33, and 32 kDa with identical N-terminal sequences. By Western blotting analysis and immunoelectron microscopy, the arginine carboxypeptidase was found to be widely distributed in the cytoplasm and on the surface of the outer membrane. The open reading frame corresponding to the N-terminal amino acids of the arginine carboxypeptidase was detected by a search of the sequence of the P. gingivalis W83 genome. This sequence showed homology with mammalian carboxypeptidases (M, N, and E/H) and included a zinc-binding region signature, suggesting that the enzyme is a member of the zinc carboxypeptidase family. The purified enzyme was inhibited by EGTA, o-phenanthroline, DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, and some metal ions, such as Cu(2+), Zn(2+), and Cd(2+). On the other hand, Co(2+) activated the enzyme. The enzyme released arginine and/or lysine from biologically active peptides containing these amino acids at the C terminus but did not cleave substrates when proline was present at the penultimate position. These results indicate that the arginine carboxypeptidase produced by P. gingivalis is an exo type of metallocarboxypeptidase. This enzyme may function to release arginine in collaboration with an arginine aminopeptidase, e.g., Arg-gingipain, to obtain specific amino acids from host tissues during the growth of P. gingivalis. (Keyword) 3-Mercaptopropionic Acid / Amino Acid Sequence / Base Sequence / Carboxypeptidase B2 / Hydrogen-Ion Concentration / Molecular Sequence Data / Molecular Weight / Porphyromonas gingivalis / Substrate Specificity (Link to Publication Site) ● Publication site (DOI): 10.1128/IAI.70.4.1807-1815.2002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11895942 ● Search Scopus @ Elsevier (PMID): 11895942 ● Search Scopus @ Elsevier (DOI): 10.1128/IAI.70.4.1807-1815.2002 (DOI: 10.1128/IAI.70.4.1807-1815.2002, PubMed: 11895942)
82.	Daisuke Hinode, Masaaki Yokoyama, Shin-ichi Tanabe, Masami Yoshioka and Ryo Nakamura : Antigenic properties of the GroEL-like protein of Campylobacter rectus, Oral Microbiology and Immunology, Vol.17, No.1, 16-21, 2002. (Summary) The purpose of this study was to clarify the antigenic properties of the GroEL-like protein of Campylobacter rectus using a specific polyclonal antibody directed to the purified 64-kDa GroEL-like protein (pAb-CrGroEL), a polyclonal antibody directed to the Actinobacillus actinomycetemcomitans GroEL-like protein (pAb-AaGroEL) and a monoclonal antibody against the recombinant human HSP60 (mAb-HuHSP60). In SDS-PAGE/Western immunoblotting analysis, mAb-HuHSP60, pAb-CrGroEL and pAb-AaGroEL were found to react with the GroEL-like protein (64-kDa) present in all C. rectus strains. A 150-kDa protein in C. rectus ATCC 33238 also reacted strongly with pAb-CrGroEL. This 150-kDa protein was found to be present on the surface-associated material of bacterial cells, as determined by transmission electron microscopy and immunogold labelling of cells with pAb-CrGroEL. Analysis of the first 20 N-terminal amino acids of the sequence of the 150-kDa protein revealed a strong homology (80%) with the C. rectus surface layer (S-layer) protein. Investigation of the biochemical nature of antigenic determinants using periodic acid and proteolytic enzymes showed that the C. rectus GroEL-like protein possessed immunodominant epitopes in both peptide and carbohydrate chains, and that the immunoreactive determinants of the 150-kDa protein belonged to carbohydrate. These results suggest that the GroEL-like protein and the S-layer protein of C. rectus may share the same carbohydrate epitopes. (Keyword) Actinobacillus actinomycetemcomitans / Antigens, Bacterial / Bacterial Outer Membrane Proteins / Bacterial Proteins / Blotting, Western / Campylobacter / Chaperonin 60 / Epitopes / Humans / Membrane Glycoproteins / Sequence Homology, Amino Acid (Link to Publication Site) ● Publication site (DOI): 10.1046/j.0902-0055.2001.00086.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11860551 ● Search Scopus @ Elsevier (PMID): 11860551 ● Search Scopus @ Elsevier (DOI): 10.1046/j.0902-0055.2001.00086.x (DOI: 10.1046/j.0902-0055.2001.00086.x, PubMed: 11860551)
83.	Kaname Masuda, Tomita Koji, Hayashi Hiroyuki, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Consumption of Peptide-derived Arginine by a Periodontopathogenic Bacterium, Porphyromonas gingivalis, Anaerobe, Vol.7, No.4, 209-217, 2001. (Link to Publication Site) ● Publication site (DOI): 10.1006/anae.2001.0383 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0035177880 (DOI: 10.1006/anae.2001.0383, Elsevier: Scopus)
84.	Masami Yoshioka, Kaname Masuda, Daisuke Hinode, 林裕行 and Ryo Nakamura : 歯周病原性細菌のプロテアーゼに対するモノクローナル抗体を利用した歯周病診断の試み, Journal of Dental Health, Vol.49, No.1, 71-78, 1999.
85.	F Goulhen, A Hafezi, V-J Uitto, Daisuke Hinode, Ryo Nakamura, Daniel Grenier and Denis Mayrand : Subcellular localization and cytotoxic activity of the GroEL-like protein isolated from Actinobacillus actinomycetemcomitans, Infection and Immunity, Vol.66, No.11, 5307-5313, 1998.
86.	Daisuke Hinode, Masami Yoshioka, Shin-ichi Tanabe, Osamu Miki, Kaname Masuda and Ryo Nakamura : The GroEL-like protein from Campylobacter rectus: immunological characterization and interleukin-6 and -8 induction in human gingival fibroblast, FEMS Microbiology Letters, Vol.167, No.1, 1-6, 1998.
87.	Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Kozaburo Nakano, Masaru Nagayama, Atsushi Suzuki, Takashi Ikeda, Eiichi Bando and Daisuke Hinode : Three Cases of Application of Osseointegrated Implant to Surgical Reconstructive Area in Oral Cancer Patients, --- Discussion of the Management of Reconstructive Soft Tissue Surrounding Implants ---, Journal of Japanese Society of Oral Implantology, Vol.11, No.2, 69-77, 1998.
88.	Daisuke Hinode, Ryo Nakamura, Grenier Daniel and Mayrand Denis : Cross-reactivity of specific antibodies directed to heat shock proteins from periodontopathogenic bacteria and of human origin, Oral Microbiology and Immunology, Vol.13, No.1, 55-58, 1998.
89.	Daisuke Hinode and Denis Mayrand : カナダ·ケベック州における衛生行政機構と地域歯科保健活動, Journal of Dental Health, Vol.47, No.1, 18-26, 1997.
90.	Daisuke Hinode, Daniel Grenier and Denis Mayrand : A general procedure for the isolation of heat-shock proteins from periodontopathogenic bacteria, Journal of Microbiological Methods, Vol.25, No.3, 349-355, 1996. (Keyword) Heat-shock protein / Immunoreactivity / Purification / Periodontopathogenic bacteria (Link to Publication Site) ● Publication site (DOI): 10.1016/0167-7012(96)00008-5 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/0167-7012(96)00008-5 (DOI: 10.1016/0167-7012(96)00008-5)
91.	Fatiha Chandad, Denis Mayrand, Daniel Grenier, Daisuke Hinode and Christian Mouton : Selection and Phenotypic Characterization of Nonhemagglutinating Mutants of Porphyromonas gingivalis, Infection and Immunity, Vol.64, No.3, 952-958, 1996.
92.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, H Hayashi, R Nakamura, D Grenier and D Mayrand : Biological and antigenic characterization of three BApNA-hydrolyzing proteases from the culture supernatant of Porphyromonas gingivalis, Oral Microbiology and Immunology, Vol.11, No.1, 8-14, 1996. (Keyword) Porphyromonas gingiivalis / BApNA-hydrolyzing protease / periodontal disease / pathogenicity
93.	Daisuke Hinode, Daniel Grenier and Denis Mayrand : Purification and Characterization of a DnaK-like and a GroEL-like Protein from Porphytomonas gingivalis, Anaerobe, Vol.1, No.5, 283-290, 1995. (Keyword) Porphyromonas gingiivalis / anaerobic bacteria / heat-shock proteins / N-terminal sequence / periodonatal disease
94.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, Kiyoko Watanabe, Toshio Umemoto, Daniel Grenier, Denis Mayrand and Ryo Nakamura : Immunological characterization and localization of a Porphyromonas gingivalis BApNA-hydrolyzing protease possessing hemagglutinating activity, FEMS microbiology letters, Vol.131, No.2, 211-217, 1995. (Keyword) BA pNA-hydrolyzing protease / Porphyromonas gingivalis / Monoclonal antibody / Hemagglutinating activity / Periodonatal disease
95.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, Hiroyuki Hayashi and Ryo Nakamura : Purification of an Extracellular Soluble Protease Possessing BApNA Hydrolytic Activity from Culture Supernatants of Porphyromonas gingivalis, Journal of Dental Health, Vol.44, No.3, 308-314, 1994. (Keyword) Porphyromonas gingiivalis / Soluble trypsin-like protease / Periodontal disease
96.	Masami Morioka, Mika Ueta, Kanako Yamato, Hiroyuki Hayashi, Daisuke Hinode, Atushi Nagata and Ryo Nakamura : Aggregation of Human Gingival Fibroblasts by Porphyromonas gingivalis, Journal of Dental Health, Vol.44, No.1, 116-121, 1994. (Keyword) Porphyromonas / gingiivalis / Human gingival fibroblast / Cell aggregation
97.	Daisuke Hinode, Atsushi Nagata, Seiko Ichimiya, Hiroyuki Hayashi, Masami Morioka, Akito Wada and Ryo Nakamura : Analysis of Factors Influencing the Prevalence of Gingival Inflammation in First-Year Junior High School Students, Journal of Dental Health, Vol.43, No.3, 272-281, 1993. (Keyword) PMA index / First-year junior high school student / Analysis of infiuencing factor
98.	H Hayashi, Masami Morioka, S Ichimiya, K Yamato, Daisuke Hinode, A Nagata and R Nakamura : Participation of an arginyl residue of insulin chain B in the inhibition of hemagglutination by Porphyromonas gingivalis, Oral Microbiology and Immunology, Vol.8, 386-389, 1993. (Keyword) Porphyromonas gingiivalis / hemagglutination / arginine-containing peptide / insulin shain B / protease substrate
99.	Daisuke Hinode, A Nagata, S Ichimiya, H Hayashi, Masami Morioka and R Nakamura : Generation of Plasma Kinin by Three Types of Protease Isolated from Porphyromonas Gingivalis 381, Archives of Oral Biology, Vol.37, No.10, 859-861, 1992. (Keyword) Kinin generarion / protease / Porphyromonas gingiivalis / periodontal disease
100.	H Hayashi, A Nagata, Daisuke Hinode, M Sato and R Nakamura : Survey of a receptor protein in human erythrocytes for hemagglutinin of Porphyromonas gingivalis, Oral Microbiology and Immunology, Vol.7, No.4, 204-211, 1992. (Keyword) Porphyromonas gingiivalis / hemagglutination / human erythrocyte / band 3 / receptor protein
101.	Masami Morioka, Kido Reiko, Daisuke Hinode, Nagata Atsushi, Sato Makoto and Ryo Nakamura : Adhesion of Porphyromonas gingivalis to human gingival fibroblast and collagen., Journal of Dental Health, Vol.42, 23-34, 1992.
102.	Masami Yoshioka, 木戸玲子, 永田篤司, Daisuke Hinode, 一宮斉子, 佐藤誠 and Ryo Nakamura : Porphyromonas gingivalis のヒト培養歯肉線維芽細胞に対する細胞毒性について, Journal of Dental Health, Vol.42, 184-190, 1992.
103.	Masami Morioka, Daisuke Hinode, Nagata Atsushi, Hayashi Hiroyuki, Ichimiya Seiko, Ueda Mika, Kido Reiko and Ryo Nakamura : Cytotoxicity of Porphyromonas gingivalis toward cultured human gingival fibroblasts, Oral Microbiology and Immunology, Vol.8, 203-205, 1992.
104.	Daisuke Hinode, Atsushi Nagata, Hiroyuki Hayashi, Junko Shimada, Makoto Sato and Ryo Nakamura : Degradative Specificity of Three Proteases from Porphyromonas Gingivalis on Mammalian Protein, Dentistry in Japan, Vol.28, 121-124, 1991. (Keyword) Porphyromonas gingiivalis / Protease / Degradative specificity / Mammalian protein
105.	Daisuke Hinode, Hiroyuki Hayashi and Ryo Nakamura : Purification and Characterization of Three Types of Proteases from Culture Supernatants of Porphyromonas gingiivaliis, Infection and Immunity, Vol.59, No.9, 3060-3068, 1991.
106.	Hiroshi Terai, Daisuke Hinode, (名) Man-yoshi, Atsushi Nagata, Makoto Sato and Ryo Nakamura : Trypsin-like Enzyme Activity and Free Amino Acid Levels in Gingival Crevicular Fluids from Adult Periodontitis Patients, Journal of Dental Health, Vol.41, No.3, 301-306, 1991. (Keyword) Gingival crevicular / Trypsin-like enzyme acivity / Free amino acid / Adult periodontitis
107.	Ryo Nakamura, Daisuke Hinode, Hiroshi Terai, Masami Morioka, Reiko Maehara, Makoto Sato, Toshiyuki Tanaka, Naoki Matsuda and Masakazu Nakamura : Isolation of a Collagenase Inhibitory Substance from Soybeans Which is Specifically Active on the Enzyme from Bacteroides gingivaliis and Its Effect on the Cell Culture of Human Gingival Fibroblast, Journal of Dental Health, Vol.39, No.3, 320-329, 1989. (Keyword) Periodontal disease / Bacteroides / Gingivalis / Soybeans / Collagenase inhibitor
108.	Daisuke Hinode, Junko Shimada, Eiji Ohara, Hiroshi Terai, Tomie Yamasaki, Akito Wada, Hajime Sagawa, Makoto Sato and Ryo Nakamura : Analysis of Factors Influencing the Caries Prevalence of Deciduous Teeth in Children of Three Years Old, Journal of Dental Health, Vol.38, No.5, 631-640, 1988. (Keyword) Dental caries of deciduous teeth / Three-year-old dental examination / Multivariant analysis
109.	Reiko Maehara, Daisuke Hinode, Hiroshi Terai, Makoto Sato, Ryo Nakamura, Naoki Matsuda, toshiyuki Tanaka and Kunio Sugihara : Inhibition of Bacterial and Mammalian Collagenolytic Activities by Tetracyclines, Journal of the Japanese Association of Periodontology, Vol.30, No.1, 182-190, 1988. (Keyword) Tetracycline-HCI / Minocycline-HCI / Bacterial collagenase / periodontal disease
110.	Yoshiaki Tomebe, Junko Endo, Daisuke Hinode, Reiko Maehara, Atsushi Nagata, Junko Shimada, Makoto Sato and Ryo Nakamura : Purification of Thiol-Dependent Collagenolytic Enzyme Isolated from Culture Supernatant of Bacteroides gingivalis 381 and Its Inhibition by Some Serum Components, Journal of Dental Health, Vol.37, No.5, 630-636, 1987. (Keyword) Collagenolytie enzyme / Bacteroides gingivalis / Serum components
111.	M Otsuka, J Endo, Daisuke Hinode, A Nagata, R Maehara, M Sato and R Nakamura : Isolation and characterization of protease from culture supernatant of Bacteroides gingivalis, Journal of Periodontal Research, Vol.22, No.6, 491-498, 1987.
112.	Makoto Sato, Atsushi Nagata, Reiko Maehara, Junko Endo, Daisuke Hinode and Ryo Nakamura : Salivary IgA Antibody to Bacteroides gingivalis and Actinobacillus actinomycetemcomitans in Patients with Adult Marginal Periodontitis, Journal of Dental Health, Vol.37, No.3, 244-249, 1987. (Keyword) Adult type of marginal periodontitis / Salivary IgA antibody / Enzyme-linked immunosorbent assay / Bacteroides / gingivalis / Actinobacillus / actinomycetemcomitans

Academic Paper (Unrefereed Paper):

1.	Natsumi Kakiuchi, Akiho Minato, Yui Okazawa, Akari Otsu, Natsumi Fujiwara, Daisuke Hinode and Hiroki Iga : A Report of Activity in a Short-term Study Abroad to Helsinki Metropolia University of Applied Sciences, Shikoku Dental Research, Vol.27, No.1, 49-53, 2014. (Tokushima University Institutional Repository) ● Metadata: 109854 (Tokushima University Institutional Repository: 109854)
2.	Masami Yoshioka, Naoko Matsumoto, Yumi Hoshimo, Daisuke Hinode, Hiroki Iga, Masaaki Yokoyama, Tetsuo Ichikawa, Fumiaki Kawano and Takafumi Noma : -, Journal of University Education Research, Vol.6, 24-43, 2009. (Summary) We prepared career advancement program "Experience learning in medical team treatment" towards the second，third and fouth year students of dental school. This program consits of prior learningconcerned with 'Team treatment and Dental profession' and experience learning in medical team treatment at Tokushima University Hospital.The purpose of this program was to rouse career conciousness as a dentalprofession. This program provided students with career image which they want to be in the future. Besides，they were motivated to study more widely to approach their own image. In this paper，we evaluated theeffects of the program"The experience learning in medical team treatment" on career advancement ofdental school students. As a result，it is suggested that this program might be fruitful as career advancement on dental students.我々は歯学部学生のキャリア形成支援のための教育プログラム「チーム医療体験学習」を開発し，歯学部の2，3，4年次の学生を対象として実施した．本プログラムは，グループワークによる事前学習とチーム医療の現場体験を2つの柱とし，学生の歯科医療職としてのキャリア意識を強化することを目的とした．プログラム終了時のアンケートから，学生には歯科専門職としての将来の姿勢や目指す方向性が具体化すると同時に幅広い知識を身につけたいといった学習に対する動機付が強化されるなど明らかな教育成果が認められた．プログラム実施前後のアンケートの分析結果から，「チーム医療体験学習」が歯学部学生のキャリア形成支援教育の手法として有効なプログラムである可能性が示唆された． (Keyword) キャリア形成支援 / チーム医療 / 体験学習 / career advancement program / medical team treatment / experience learning (Tokushima University Institutional Repository) ● Metadata: 82689 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812440494080 (Tokushima University Institutional Repository: 82689, CiNii: 1050282812440494080)

Review, Commentary:

1.	埴岡隆, 青山旬, 川口陽子, 小島美樹, Daisuke Hinode, 尾崎哲則, 山中玲子, 瀬川洋, 細見環, 田野ルミ, 千葉逸朗, 三宅達郎, 小川祐司, 平田幸夫, 三宅達郎, 谷口奈央, 井下英二, 花田信弘, 眞木吉信 and 於保孝彦 : 歯科医師・歯科衛生士養成機関における禁煙介入教育の課題と展望, 口腔衛生会誌, Vol.67, No.4, 298-305, 2017.
2.	Daisuke Hinode, Tokiko Doi, Hiromi Nakae, Masami Yoshioka, 福島襄 and 阿部昭人 : 学校歯科保健支援ICTシステムを用いた学校歯科保健活動, 日本学校歯科医会会誌, Vol.118, 6-13, Sep. 2015.
3.	Daisuke Hinode : 口臭の診断と口臭治療, Shikoku Dental Research, Vol.27, No.2, 107-111, Feb. 2015. (Keyword) 口臭 / smoking (Tokushima University Institutional Repository) ● Metadata: 109860 (Tokushima University Institutional Repository: 109860)
4.	埴岡隆, 青山旬, 稲葉大輔, 小川祐司, 尾崎哲則, 小島美樹, 川口陽子, 小林清吾, 千葉逸朗, 平田幸夫, 岡崎好秀, Daisuke Hinode, 三宅達郎 and 花田信弘 : 本で発売された口腔内使用無煙タバコ(スヌース)に関連する資料, 口腔衛生会誌, Vol.64, No.1, 34-38, Apr. 2014.
5.	埴岡隆, 青山旬, 稲葉大輔, 小川祐司, 小島美樹, 川口陽子, 小林清吾, 千葉逸朗, 平田幸夫, 岡崎好秀, Daisuke Hinode, 三宅達郎, 花田信弘 and 尾崎哲則 : 口腔で使用される無煙タバコの健康被害とタバコ対策への影響, 口腔衛生会誌, Vol.64, No.5, 420-424, 2014.
6.	埴岡隆, 青山旬, 稲葉大輔, 小川祐司, 尾崎哲則, 小島美樹, 川口陽子, 小林清吾, 千葉逸朗, 平田幸夫, 岡崎好秀, Daisuke Hinode, 三宅達郎 and 花田信弘 : 歯科口腔保健領域におけるたばこ対策の更なる推進のために ─歯科医師および歯科衛生士による禁煙指導・禁煙支援の文献レビューによる今後の禁煙推進活動への提言─, Journal of Dental Health, Vol.63, No.5, 453-457, Oct. 2013. (Keyword) たばこ対策 / 歯科 / 口腔保健 / 文献レビュー / 禁煙支援 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853833836415488 (CiNii: 1520853833836415488)
7.	Fumiaki Kawano, Daisuke Hinode and Yasuhiko Shirayama : フィンランドの医療・福祉分野におけるICTの活用, Shikoku Dental Research, Vol.25, No.2, 89-92, Feb. 2013. (Keyword) フィンランド / medical infomatics / medical care / welfare / ICT (Tokushima University Institutional Repository) ● Metadata: 109835 (Tokushima University Institutional Repository: 109835)
8.	Daisuke Hinode, Masami Yoshioka, Masaaki Yokoyama, 竹田信也, 米津隆仁, 藤原愛一郎 and 豊嶋健治 : 歯科保健調査結果の防煙活動への有効活用についての提言, Japanese Journal of Smoking Control Science, Vol.5, No.6, 1-5, 2011. (Link to Publication Site) ● Publication site (DOI): 10.32213/jascs.vol.5.06_1 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.32213/jascs.vol.5.06_1 (DOI: 10.32213/jascs.vol.5.06_1)
9.	Masaaki Yokoyama, Masami Yoshioka, Yoko Abe, 裕美藤井, Naoko Matsumoto, Yumi Hoshimo, Yuka Sogawa, 幸江真杉, Harumi Sakamoto, 薫廣瀬, Nozomi Yokoyama, Kanako Tamatani and Daisuke Hinode : Oral Care by Dental Professionals for Patients Undergoing Respiratory Care at Tokushima University Hospital Intensive Care Unit, Journal of Dental Health, Vol.59, No.2, 132-140, Mar. 2009. (Summary) Intensive oral care during the perioperative period can reduce oral biofilm, which represents a risk factor for respiratory diseases such as aspiration and ventilator-associated pneumonia. The aim of this study was to establish a standardized procedure for oral care in order to reduce the risk of infectious disease complications in inpatients undergoing respiratory care in the Intensive Care Unit (ICU) of Tokushima University Hospital. In collaboration with nurses, professional oral care was provided once a day to inpatients at high risk of respiratory infections. At the initial oral examination, the majority of patients in the ICU had dry lips, and showed a tongue coating and the presence of oral debris (i.e., dental plaque and/or sputum) on tooth and oral mucosa surfaces. In addition, we sometimes observed ulcer formation in the oral mucosa as well as tooth mobility, which are conditions that ICU staff members should pay attention to when fixing the endotracheal tube. Our professional oral care procedure reduced oral debris, dry mouth, and oral malodor to some extent in the majority of ICU patients. Close cooperation between dental professionals, nurses, and medical doctors was promoted through this activity. In conclusion, the multi-professional team approach adopted in this study means that patients in the ICU can be provided with advanced oral care, and it may contribute to reduce the risk of infectious disease complications. (Keyword) Oral care / ICU / Dental professional / Multi-professional team (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205004260864 (CiNii: 1390001205004260864)
10.	Daisuke Hinode, Shin-ichi Tanabe, Masaaki Yokoyama, Kenji Fujisawa, Eiji Yamauchi and Youji Miyamoto : Influence of smoking on osseointegrated implant failure: a meta-analysis, Clinical Oral Implants Research, Vol.17, No.4, 473-478, Aug. 2006. (Summary) The aim of this study was to examine the influence of smoking on osseointegrated implant failure by performing a meta-analysis. A computerized literature search using PubMed database (in English) and Japana Centra Revuo Medicina (in Japanese) was carried out to identify all relevant studies. Among 175 studies identified and chosen for detailed review, 19 were appropriate for inclusion in our meta-analysis. When smokers were compared with non-smokers, odds ratio (OR) for osseointegrated implant failure was significantly elevated (OR 2.17, 95% confidence intervals (CI), 1.67-2.83). Seven studies were appropriate to examine the influence of intra-oral location (maxillary arch vs. mandibular arch) of implant failure on smoking. The OR for implant failure occurring in the maxillary arch was significantly elevated (OR 2.06, 95% CI, 1.61-2.65), whereas the OR in the mandibular arch did not demonstrate a significant increased risk associated with smoking (OR 1.32, 95% CI, 0.72-2.4). Our meta-analysis revealed a significant relationship between smoking and the risk of osseointegrated implant failure, more particularly those implants located in the maxillary arch. (Keyword) Dental Arch / Dental Implantation, Endosseous / Dental Implants / Dental Restoration Failure / Epidemiologic Methods / Humans / Mandible / Maxilla / Smoking (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1600-0501.2005.01244.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16907781 ● Search Scopus @ Elsevier (PMID): 16907781 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0501.2005.01244.x (DOI: 10.1111/j.1600-0501.2005.01244.x, PubMed: 16907781)
11.	Masami Yoshioka, 裕美藤井, 薫廣瀬, Harumi Sakamoto, Yuka Sogawa, Akiko Satoh, Makoto Fukui, Masaaki Yokoyama and Daisuke Hinode : Professional Oral Care of Inpatients by Members of the Nutrition Support Team in Tokushima University Medical and Dental Hospital, Journal of Dental Health, Vol.56, No.3, 309-317, Jul. 2006. (Summary) As members of the Nutrition Support Team (NST) at Tokushima University Medical and Dental Hospital, we have worked on professional oral care (POC) with our inpatients. Also, we started bedside POC with inpatients after studying their health and nutrient intake. This led us to have a closer working relation with ward staff and improve the oral care provided by nurses during their routine work. The results of the first oral examination of 43 inpatients we have included so far showed that the percentage of oral problems such as tongue coating, debris, dental plaque, calculus, expectoration, dry mouth, and bad breath were considerably high. Many of these oral conditions were thought to be related to the patients' physical conditions. After POC, however, improvements in patients' oral conditions were noted in more than 50 percent of the cases. Consequently, it can be said that the POC provided by the NST has not only improved the oral hygiene condition of patients but also nurtured closer working relations among departmental staff in the hospital. (Keyword) Nutrition support team / Professional oral care / Cooperation with staff (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205002281088 (CiNii: 1390001205002281088)
12.	Masami Yoshioka, Masaaki Yokoyama, Tomoaki Honna, Makoto Fukui, Nozomi Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Harumi Sakamoto, Akiko Satoh, Ryo Nakamura and Daisuke Hinode : 予防歯科臨床における定期的口腔健康管理, Shikoku Dental Research, Vol.16, No.2, 401-409, Jan. 2004. (Keyword) 定期的口腔健康管理 / 支援的歯周治療 / 予防歯科臨床 / 歯周疾患指導管理票 / 動機付け
13.	Masaaki Yokoyama, Daisuke Hinode, Masami Yoshioka and Ryo Nakamura : 口腔疾患及び歯科治療に対する喫煙の影響, Shikoku Dental Research, Vol.16, No.1, 369-376, Jun. 2003. (Keyword) 口腔疾患 / 歯科治療 / smoking
14.	Shin-ichi Tanabe, Daisuke Hinode, Masaaki Yokoyama, Youji Miyamoto and Ryo Nakamura : 骨結合型インプラント治療の予後に対する喫煙の影響文献的考察から, Journal of Dental Health, Vol.51, No.3, 196-202, Jul. 2001.
15.	Masami Yoshioka, 赤木毅, 松岡希実, Daisuke Hinode and Ryo Nakamura : 口臭診査·治療の実際, Shikoku Dental Research, Vol.14, No.1, 205-217, Jun. 2001.
16.	Daisuke Hinode, Shin-ichi Tanabe, Masami Yoshioka and Ryo Nakamura : 歯周病原性細菌の産生する熱ショック蛋白質, Journal of Dental Health, Vol.50, No.1, 2-11, Jan. 2000.

Proceeding of International Conference:

1.	R Prihastuti, Daisuke Hinode, Makoto Fukui, Omar Maningo Rodis and Yoshizo Matsuka : Enhancement of oral hygiene behavior and oral health outcomes following the theory-based educational intervention, International Symposium on Dental Hygiene 2024, Seoul, Jul. 2024.
2.	R Prihastuti, Daisuke Hinode, Makoto Fukui, Omar Maningo Rodis and Yoshizo Matsuka : Two different oral hygiene measurements following a theory-based educational intervention, Japanese Association for Dental Research, Sendai, Nov. 2023.
3.	Keiko Aota, Tsuruta Mai, Okamoto Tomomi, Masugi Sachie, Shinji Ono, Kanakawa Hiroko, Hideyuki Takano, Makoto Fukui and Daisuke Hinode : Factors associated with the development of oral mucositis in pharyngeal cancer patients receiving chemoradiotherapy, The 3rd Annual Meeting of the International Society of Oral Care, Apr. 2023.
4.	Daisuke Hinode : Development of an international e-learning material on common risk factor approach for dental hygiene students, A webinar on Common Risk Factor Approach, Helsinki, Jan. 2021. (Summary) 1
5.	Yuka Sogawa, Makoto Fukui, Shingen Nakamura, Kimiko Sogabe, Ryohei Sumitani, Masami Yoshioka, Masahiro Abe and Daisuke Hinode : Risk factors for chemotherapy-induced febrile neutropenia in hematological cancer patients, 106th Annual Meeting of American Academy of Periodontology, Honolulu, Nov. 2020. (Summary) 1
6.	Daisuke Hinode and Fumiaki Kawano : Relationship between oral health and general health or medical expenses in the latter-stage elderly, Dentisphere 4th International Scientific Meeting in conjunction with 5th ASEAN Plus Tokushima Joint International Conference (November 29-30, 2019, Indnesia), Nov. 2019.
7.	Makoto Fukui, Tokiko Doi, Harumi Sakamoto, Masami Yoshioka, 岡本好史, Shuji Mori, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : Long-term smoking affects the oral health status of latter-stage elderly males and increases the cost of dental treatment, 第15回国際タバコ病予防学会学術総会, Tokyo, Oct. 2019. (Keyword) smoking / 口腔健康状態 / 歯科医療費 / 後期高齢者
8.	Harumi Sakamoto, Makoto Fukui, Daisuke Hinode and Masami Yoshioka : The usefulness of prenatal dental health check-ups., 21st International symposium on Dental Hygiene (August 13-16, 2019, Brisben, Australia, Aug. 2019.
9.	Masami Yoshioka, Yoshifumi Okamoto, Daisuke Hinode, Shizuko Yanagisawa, Yasuhiko Shirayama and Kojiro Nagai : Association between Periodontal Status and Renal Function in Middle-aged Men, IADR/AADR/CADR General Session & Exhibition, Jun. 2019.
10.	Yumi Kuwamura, Sumiko Yoshida, Kiyoe Kurahashi, Masuko Sumikawa, Eijiro Sakamoto, Akio Kuroda, Hikari Yamato, Misuzu Okamoto, Hirokazu Uemura, Daisuke Hinode, Hiromichi Yumoto, Ken-ichi Aihara, Makoto Funaki, Munehide Matsuhisa, Itsuro Endo and Sachi Kishida : Oral health behaviors of outpatients with diabetes based on the Revised Diabetes Oral Health Assessment Tool for nurses, Journal of Diabetes Investigation, Vol.10, No.Supplement1, 26, Sendai-City, Miyagi Prefecture, May 2019. (Keyword) oral health behaviors / diabetes nursing / assessment
11.	Omar Maningo Rodis, Daisuke Hinode and Hiroki Iga : Educating Future Health Care Professionals through Japan's 8020 Program, A Seminar on Interdisciplinary Education in Nursing and Oral Health Care of Elderly, Tokushima, Mar. 2019.
12.	Yuki Matsumura, Daisuke Hinode, Masami Yoshioka, Asakuma Hiroki and Takii Hiroshi : Effect of kiwifruit and blueberry extract against bacterial VSC production, 96th General session of the International Association for Dental Research, London, UK, Jul. 2018.
13.	Satomi Moriyama, Daisuke Hinode, Masami Yoshioka, Yuka Sogawa, Takeshi Nishino, Akira Tangoku and Daniel Grenier : Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy: a clinical trial, 65th Annual Meeting of the Japanese Association for Dental Research, Showa University, Tokyo, Japan, Nov. 2017.
14.	Yui Okazawa, Daisuke Hinode, Tokiko Doi, Masami Yoshioka and Daniel Grenier : Comparison of Oral Malodor and Microbiome in Smokers and Non-smokers, The 95th General Session & Exhibition of the IADR, San Francisco, Calif., USA, Mar. 2017.
15.	Tokiko Doi, Daisuke Hinode, Hiromi Nakae and Masami Yoshioka : Intervention study regarding sufficient chewing behavior in Japanese primary school children., 20th International Symposium on Dental Hygiene, Schweiz (Basel), Jun. 2016.
16.	Hiromi Nakae, Masami Yoshioka and Daisuke Hinode : Pronlems on oral healthcare in convalescent hospitals -Questionnaire survey for non-dental professionals-, 20th International Symposium on Dental Hygiene, Jun. 2016. (Keyword) oral healthcare / convalescent hospitals / non-dental professionals / questionnaire
17.	Masami Yoshioka, Yasuhiko Shirayama, Issei Imoto, Daisuke Hinode, Shizuko Yanagisawa, Yuko Takeuchi, Yamasaki Akika and Bando Takashi : Factors associated with regular dental visits among hemodialysis patients, The 12 International Conference of Asian Academy of Preventive Dentistry Joint meeting with The 65th General Meeting of Japanese Society for Oral Health, May 2016.
18.	Tokiko Doi, Daisuke Hinode, Hiromi Nakae and Masami Yoshioka : Relationship between obesity and oral health in high school students, The 12th International Conference of Asian Academy of Preventive Dentisitry Joint meeting with The 65th General Meeting of Japanese Society for Oral Health, May 2016.
19.	Tokiko Doi, Daisuke Hinode, Hiromi Nakae, Satsuki Yabuuchi, Kanako Tamatani, Masami Yoshioka, Miwa Matsuyama, Masanori Nakano, Hiroki Iga and Yuzuru Fukushima : The effect of the education program chewing 30 through the information and communication technology system, The 3rd Asian plus and Tokushima Joint International Conference, Indonesia, Dec. 2014.
20.	Daisuke Hinode, Tokiko Doi, Hiromi Nakae, Satsuki Yabuuchi, Kanako Tamatani, Masami Yoshioka, Miwa Matsuyama, Hiroki Iga, Hiroki Iga and Yuzuru Fukushima : Relationship between sufficient chewing behavior and oral conditions in Japanese primary school children through the chewing 30 program, 100th Annual Meeting of American Academy of Periodontology, Sep. 2014.
21.	Daisuke Hinode and Satsuki Yabuuchi : Relationship between sufficient chewing behavior and oral conditions in Japanese primary school children through the chewing 30 program, Sep. 2014.
22.	Daisuke Hinode and Masami Yoshioka : Oral Health of Pregnant Women and Low Birth Weight Outcome, 10th IADR World Congress on Preventive Dentistry, Budapest, Oct. 2013.
23.	Masami Yoshioka and Daisuke Hinode : Subjective oral symptom of patient with lung cancer during chemotherapy, 10th IADR World Congress on Preventive Dentistry, Budapest, Oct. 2013.
24.	Doi Tokiko, Daisuke Hinode, Hiromi Nakae, Yabuuchi Satsuki, Kanako Tamatani, Masami Yoshioka, Miwa Matsuyama, Masanori Nakano, Hiroki Iga and Fukushima Yuzuru : Relationship between lifestyle and oral health conditions in school children, International Week 2013, May 2013.
25.	Daisuke Hinode and Masami Yoshioka : Relationship between halitosis and periodontopathogenic bacteria in tongue coating, 91th General session of the International Association for Dental Research, Seattle, Mar. 2013.
26.	Daisuke Hinode and Natsumi Fujiwara : Tongue coating and oral malodor, Helsinki Metropolia University of Applied Sciences International Meeting, Helsinki, Finland, Mar. 2011.
27.	Yumi Hoshimo, Natsumi Fujiwara, Atsuko Nakamichi and Daisuke Hinode : Introduction of the clinical basic training using new teaching device and evaluation by OSCE for the dental hygienist education in The University of Tokushima, Helsinki Metropolia University of Applied Sciences International Meeting, Helsinki, Finland, Mar. 2011.
28.	Daisuke Hinode, Masaaki Yokoyama and Masami Yoshioka : Relationship between smoking, oral health status of pregnant women and low birth weight outcome, 96th Annual Meeting of American Academy of Periodontology, Honolulu, Nov. 2010.
29.	Daisuke Hinode, Masaaki Yokoyama, Makoto Fukui, Nozomi Yokoyama, Kanako Tamatani and Masami Yoshioka : The Effect of Tongue Cleaning on Oral Malodor, 86th General Session & Exhibition of the IADR/ 32nd Annual Meeting of the CADR, Toronto, Jul. 2008.
30.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito : Salivary Stress Makers in Patients with Complaint of Halitosis., 7th Congress of Asian Academy of Preventive Dentistry, Okayama, Nov. 2006.
31.	Daisuke Hinode, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe and Masami Yoshioka : Role of Salivary IgA directed to GroEL in Periodontitis Patients., 84th General Session & Exhibition of the International Association for Dental Research, Brisbane, Jun. 2006.
32.	Masami Yoshioka, Kaname Masuda, Nozomi Yokoyama, Masaaki Yokoyama, Shin-ichi Tanabe, Daisuke Hinode and Daniel Grenier : Contribution of Peptostreptococcus Micros proteases in cytokine response by human gingival fibroblasts, 4th General Annual Meeting of the International Conference on Protease Inhibitors, Quebec City, Oct. 2005.
33.	Kanako Tamatani, Masami Yoshioka, Tetsuya Tamatani, Daisuke Hinode and R Nakamura : Purification and characterization of the trypsin-like enzymes from Tannerella forsythensis, 83rd General session of the International Association for Dental Research, Baltimore, U.S.A, Mar. 2005.
34.	H Nagata, M Ojima, Daisuke Hinode, Makoto Fukui, A Takemura, S.G Grossi, S Shizukuishi and R Nakamura : Vitamin C and E supplements supress periodontal disease in smokers, Annual Meeting of American Academy of Periodontology, San Francisco, Sep. 2003.
35.	Daisuke Hinode, Makoto Fukui and R Nakamura : The relationship between tongue coating and Secretory- IgA level in saliva from patients complaining of oral malodor, China-Japan Medical Conference 2002, Beijing, Nov. 2002.
36.	Daisuke Hinode, Masaaki Yokoyama and Ryo Nakamura : Immunological characteristics of the flagellin from Campylobacter rectus, 102nd General meeting of American Society for Microbiology, Salt Lake City, U.S.A, Mar. 2002.
37.	Masaaki Yokoyama, Shin-ichi Tanabe, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Immunological characterization of the GroEL-like protein from Campylobacter rectus, 80th General session of the International Association for Dental Research, San Diego, Mar. 2002.
38.	Nozomi Yokoyama, Kaname Masuda, Masami Yoshioka, Masaaki Yokoyama, Daisuke Hinode and Ryo Nakamura : Effect of Hydroxamic Acid-Based MMP Inhibitors on Human Gingival Cells, 80th General session of the International Association for Dental Research, San Diego, Mar. 2002. (Keyword) MMP / gingiva
39.	Makoto Fukui, Nozomi Matsuoka, Tuyoshi Akagi, Shin-ichi Tanabe, Kanako Tamatani, Masaaki Yokoyama, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : The relationship between tongue plaque and secretary-IgA in saliva from patients with breath odor, Fifth International Conference on Breath Odor Research, Tokyo, Jul. 2001.
40.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Daisuke Hinode and Ryo Nakamura : Immunological relationship between periodontopathogenic bacteria and Helicobacter pylori, Journal of Dental Research, Vol.80, No.Special Issue, 679, Chiba, Mar. 2001.
41.	Kaname Masuda, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Characterization of Arginine Carboxypeptidase from Porphryomonas gingivalis, Journal of Dental Research, Vol.78, Vancouver, Mar. 1999.
42.	Daisuke Hinode, Shin-ichi Tanabe, Osamu Miki, Kaname Masuda, Masami Yoshioka and Ryo Nakamura : Interleukin Secretion by the GroEL-like Protein from Campylobacter rectus., Journal of Dental Research, Vol.78, No.Special Issue, 418, Vancouver, Canada, Mar. 1999.
43.	Masami Yoshioka, Miki Osamu, Daisuke Hinode and Ryo Nakamura : Influence of Porphyromonas gingivalis on Cultured Human Gingival Fibroblasts, Journal of Dental Research, Nice, Jun. 1998.
44.	Daisuke Hinode, Shin-ichi Tanabe, Masami Yoshioka and Ryo Nakamura : Characterization of Non Hemagglutinating Mutants of Porphyromonas gingivalis., Journal of Dental Research, Vol.77, No.Special Issue B, 855, Nice, France, Mar. 1998.
45.	Daisuke Hinode, R Nakamura, D Grenier and D Mayrand : Immunological studies of heat shock proteins from periodontopathogenic bacteria, 75th General session of the International Association for Dental Research, Orlando, Mar. 1997.
46.	Daisuke Hinode, D Grenier and D Mayrand : An isolation procedure of heat shock proteins from periodontopathogenic bacteria, 74th General session of the International Association for Dental Research, San Francisco, Mar. 1996.
47.	C Vayssie, Daisuke Hinode, D Grenier and D Mayrand : Detection and purification of a GroEL- like protein from Porphyromonas gingivalis, 24th Annual meeting of the American Association for Dental Research, San Antonio, U.S.A, Mar. 1995.
48.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, H Hayashi, R Nakamura, D Grenier and D Mayrand : Characterization of three BApNA hydrolyzing proteases from Porphyromonas gingivalis, 24th Annual meeting of the American Association for Dental Research, San Antonio, U.S.A, Mar. 1995.

Proceeding of Domestic Conference:

1.	Youji Miyamoto, Kenji Fujisawa, Seiko Tatehara, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi and Daisuke Hinode : ブローネマルクインプラントを使用した即時荷重インプラントの経験, 第47回日本口腔外科学会, (Summary) 1
2.	住友孝史, Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : インプラントの表面形状がオッセオインテグレーション獲得に及ぼす影響一滑面と粗面インプラントの比較-, 第33回日本口腔インプラント学会総会, (Summary) 1
3.	Masami Yoshioka, Hiromi Nakae, Makoto Fukui, Shizuko Yanagisawa, Yuka Sogawa, Harumi Sakamoto and Daisuke Hinode : 歯磨き習慣とリンクさせた動画視聴の教育的効果の検討, 第72回日本口腔衛生学会総会, May 2023.
4.	鶴田真生, 清野方子, 田倉幸子, 福島みどり, 岡本知美, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano, Makoto Fukui, Daisuke Hinode and Keiko Aota : 咽頭がん化学放射線療法患者の口腔粘膜炎発症に影響を与える因子に関する研究, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
5.	Keiko Aota, 鶴田真生, 岡本知美, 幸江真杉, Shinji Ono, 金川裕子, Hideyuki Takano, Makoto Fukui and Daisuke Hinode : Factors associated with the development of oral mucositis in pharyngeal cancer patients receiving chemoradiotherapy, 第20回日本口腔ケア学会総会・学術集会, Apr. 2023.
6.	篠原千尋, Masami Yoshioka, 中江弘美, 十川悠香, Harumi Sakamoto, Makoto Fukui, Daisuke Hinode and 中野雅徳 : 経口摂取要介護高齢者の発熱に影響する因子の検討, 令和4年度四国公衆衛生研究発表会, Feb. 2023.
7.	OYA Yukie, 稲垣幸司, 増田麻里, 北村優依 and Daisuke Hinode : 歯科衛生士をめざす学生の加熱式タバコを含めた受動喫煙曝露状況と毛細血管血流速度との関連性の検討, 第16回日本禁煙学会学術総会学会, Oct. 2022.
8.	Masami Yoshioka, 中江弘美, Makoto Fukui, 篠原千尋, 十川悠香, Harumi Sakamoto and Daisuke Hinode : コモンリスクファクターアプローチのツールとしての口腔保健教育動画の開発, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
9.	Tokiko Doi, Makoto Fukui, Harumi Sakamoto, 下村学, 岡本好史, 松本侯, Masami Yoshioka and Daisuke Hinode : 後期高齢者のオーラルフレイル予防を目的とした健口体操の効果, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
10.	AMOH Saki, Makoto Fukui, 福島みどり, 佐原久美子, 武川香織, 幸江真杉, 十川悠香, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode : 悪性リンパ腫患者の好中球減少に伴う発熱に関連する口腔環境因子の解明, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
11.	SONE Ichika, Tokiko Doi, Makoto Fukui, 下村学, 岡本好史, 松本侯, Miwa Matsuyama, Masami Yoshioka and Daisuke Hinode : 高齢者の口腔環境と肺炎発症との関連性, 第33回近畿・中国・四国口腔衛生学会総会, Oct. 2022.
12.	Harumi Sakamoto, Makoto Fukui, Tokiko Doi, KUBO Eri, Masami Yoshioka and Daisuke Hinode : 3歳児のう蝕発症に関与する1歳6か月児健診時点での要因の分析, 日本歯科衛生学会第17回学術大会, Sep. 2022.
13.	Izumi Sasaki, Makoto Fukui, Harumi Sakamoto, Kanako Tamatani and Daisuke Hinode : 口臭症患者に認められる揮発性硫黄化合物と口腔環境との関連性, 日本口腔衛生学会, May 2022.
14.	Eri Kubo, Harumi Sakamoto, Makoto Fukui and Daisuke Hinode : 妊婦の口腔環境改善に関する課題の検討, 日本口腔衛生学会, May 2022.
15.	Masami Yoshioka, 川島友一郎, Makoto Fukui, Shizuko Yanagisawa, Hiromi Nakae, Yuka Sogawa and Daisuke Hinode : 糖尿病外来患者の血糖および体重コントロールに関連する因子の検討―2年間のコホート研究より―, 第70回日本口腔衛生学会総会, May 2022.
16.	福島みどり, 幸江真杉, 武川香織, Saki Amoh, Kanako Tamatani, Makoto Fukui, 金川裕子 and Daisuke Hinode : 大学病院での歯科衛生士業務の効率化に関する調査(第2報), 第32回近畿・中国・四国口腔衛生学会総会, Oct. 2021.
17.	Kumiko Sahara, Makoto Fukui, Harumi Sakamoto, Tokiko Doi, Masami Yoshioka, 岡本好史, 松本侯, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : 後期高齢者の口腔状態と要介護認定または死亡発生との関連性, 第32回近畿・中国・四国口腔衛生学会総会, Oct. 2021.
18.	Masami Yoshioka, 川島友一郎, Makoto Fukui, Shizuko Yanagisawa, Hiromi Nakae, Yuka Sogawa and Daisuke Hinode : 糖尿病外来患者の口腔健康状態/歯科保健行動と高LDLコレステロール血症との関連性, 日本口腔衛生学会特別大会(第24回日本歯科医学会学術大会), Sep. 2021.
19.	渡辺美南, Harumi Sakamoto, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : 母親の喫煙習慣と歯科保健行動および子どもの口腔状態との関連性, 第15回日本禁煙科学会学術総会, Dec. 2020.
20.	Makoto Fukui, 佐原久美子, Tokiko Doi, Harumi Sakamoto, Masami Yoshioka, Miwa Matsuyama, Fumiaki Kawano, 岡本好史, Shuji Mori and Daisuke Hinode : オーラルフレイル関連項目と医療費の関連性, 第31回近畿・中国・四国口腔衛生学会総会, Oct. 2020. (Keyword) diabetes mellitus / 口腔状態 / 医療費 / 後期高齢者
21.	Masami Yoshioka, 川島友一郎, 南明香, Makoto Fukui, Shizuko Yanagisawa and Daisuke Hinode : 糖尿病コントロールを表す臨床指標と歯科保健行動との関連性, 第69回日本口腔衛生学会総会, Apr. 2020.
22.	Harumi Sakamoto, Minami Watanabe, Daisuke Hinode, Makoto Fukui, Masami Yoshioka, 藤川貴代, 喜來浩子 and 四宮宣尚 : 妊産婦の喫煙習慣と歯科保健行動との関連性, 令和元年度四国公衆衛生研究発表会(2020年2月14日，阿波銀ホール・徳島市), Feb. 2020.
23.	Masami Yoshioka, 川島友一郎, Yoshihiko Noma, Daisuke Hinode, Shizuko Yanagisawa and Yasuhiko Shirayama : 糖尿病外来患者の歯科的課題-口腔内の自覚症状と歯科保健行動との関連-, 第65回四国公衆衛生学会総会, Feb. 2020.
24.	福島みどり, 田口侑子, 武川香織, 幸江真杉, Kanako Tamatani, Makoto Fukui, Masami Yoshioka, 金川裕子 and Daisuke Hinode : 大学病院での歯科衛生士業務の効率化に関する調査(第1報), 第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019.
25.	Kumiko Sahara, Tokiko Doi, Makoto Fukui, Harumi Sakamoto, Masami Yoshioka, 岡本好史, Shuji Mori, Miwa Matsuyama, Fumiaki Kawano and Daisuke Hinode : 後期高齢者における糖尿病と口腔状態および医療費の関連性, 第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019. (Keyword) diabetes mellitus / 口腔状態 / 医療費 / 後期高齢者
26.	渡辺美南, Harumi Sakamoto, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : 妊産婦の喫煙習慣と歯科保健行動及び子どもの口腔状態との関連性, 第14回日本禁煙科学会学術総会, Sep. 2019.
27.	久野恵, Natsumi Fujiwara, 篠永晴美, 迎美榛, Harumi Sakamoto, 田村真里奈, Akari Watanabe, Miwa Matsuyama, Kazumi Ozaki and Daisuke Hinode : 摂食・嚥下リハビリテーション臨床実習における歯科衛生士学生の学びと教育的効果, 日本歯科衛生学会第14回学術大会(愛知県名古屋市), Sep. 2019.
28.	Yuka Sogawa, Masami Yoshioka, 南明香, Makoto Fukui, Daisuke Hinode, Shingen Nakamura and Masahiro Abe : 自家末梢血幹細胞移植患者の口腔ケアによる口腔粘膜炎障害の低減効果, 第68回日本口腔衛生学会総会, May 2019.
29.	Masami Yoshioka, 川島友一郎, 野間喜彦, 南明香, Daisuke Hinode, Shizuko Yanagisawa and Yasuhiko Shirayama : 糖尿病外来患者の食習慣と口腔保健との関連, 第64回四国公衆衛生学会総会, Feb. 2019.
30.	Harumi Sakamoto, Minami Watanabe, Daisuke Hinode, Makoto Fukui, Masami Yoshioka, 藤川貴代, 喜來浩子 and 四宮宣尚 : 妊産婦の喫煙習慣と歯科保健行動との関連性, 平成30年度四国公衆衛生研究発表会, Feb. 2019.
31.	Hiroki Iga, Daisuke Hinode, Omar Maningo Rodis and Fumiaki Kawano : 交換留学生プログラムに導入したヒト型患者ロボットによる歯科衛生士の態度・技能教育の試み, 平成30年度全学FD推進プログラム大学教育カンファレンス in 徳島発表抄録集, 30-31, Dec. 2018. (Summary) 歯学部はフィンランドの歯科衛生士養成機関であるメトロポリア応用科学大学と学術協定を締結し，グローカルな人材育成に取り組んできた．その一つとして毎年，交換留学生の派遣・受入プログラムを実施している．本研究では平成29年度の受入留学生を対象にヒト型患者ロボット(シムロイドⓇ)を用いて英語による態度・技能教育プログラムを実施したのでその概要と成果および今後の展開について発表する．
32.	河野りか, Tokiko Doi, Makoto Fukui, 松村佑季, Harumi Sakamoto, Kanako Tamatani, Masami Yoshioka, 福島襄, 阿部昭人 and Daisuke Hinode : 児童の肥満と口腔状態および生活習慣の関連性, 第29回近畿・中国・四国口腔衛生学会, Sep. 2018.
33.	Yuki Matsumura, Daisuke Hinode, Tokiko Doi, Harumi Sakamoto, Rika Kawano, Masami Yoshioka, 滝井寛 and 朝熊弘樹 : 舌苔中の細菌および口臭に対する口中ケアタブレットの有効性の検討, 第67回口腔衛生学会・総会, May 2018.
34.	Masami Yoshioka, Shizuko Yanagisawa, Yasuhiko Shirayama and Daisuke Hinode : 居宅・施設・病院で歯科衛生士が用いる口腔ケア用品の使用状況と選択理由, 第67回口腔衛生学会・総会, May 2018.
35.	Masami Yoshioka, Shizuko Yanagisawa, Yasuhiko Shirayama and Daisuke Hinode : 居宅・施設・病院で歯科衛生士が選択する口腔ケア用品の使用状況とその理由, 第67回日本口腔衛生学会・総会, May 2018.
36.	Harumi Sakamoto, 西山花生, Daisuke Hinode, Masami Yoshioka, 藤川貴代 and 喜来浩子 : 妊娠期の歯科健康診査の有用性, 平成29年度四国公衆衛生研究発表会, Jan. 2018.
37.	Masami Yoshioka, 岡本好史, 村田昌弘, 岸彰, 岡部仁史, 片山美寿江 and Daisuke Hinode : 歯周病とメタボリックシンドローム関連指標との関連性の検討，―阿南市・那賀町における医科歯科連携事業受診者データより―, 第60回四国公衆衛生学会総会平成26年度四国公衆衛生研究発表会, Jan. 2018.
38.	Moriyama Satomi, Daisuke Hinode, Masami Yoshioka, Sogawa Yuka, Denis Mayrand, Takeshi Nishino, Akira Tangoku and Daniel Grenier : Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy: a clinical trial, 65th Annual Meeting of the Japanese Association for Dental Research, Nov. 2017.
39.	Hiroki Iga, Daisuke Hinode, Yasusei Kudo, Naozumi Ishimaru and Yasuhiko Shirayama : 国際教育連携を活用した新しい歯科衛生士教育の試みと今後の展開, 第65回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2017. (Keyword) 口腔保健 / 歯科衛生士
40.	河野りか, Tokiko Doi, 松村佑季, Daisuke Hinode, Masami Yoshioka, 中江弘美, 福島襄 and 阿部昭人 : 児童の食習慣と肥満との関連性, 第82回全国学校歯科保健研究大会, Oct. 2017.
41.	松村佑季, Daisuke Hinode, 十川悠香, 山崎明香 and Masami Yoshioka : ブルーベリーのFusobacterium nucleatum発育抑制およびメチルメルカプタン産生抑制への関与, 第28回近畿・中国・四国口腔衛生学会総会, Oct. 2017.
42.	十川悠香, Daisuke Hinode, Masami Yoshioka and 真杉幸江 : がん化学療法患者の有害事象と口腔細菌の関連, 第28回近畿・中国・四国口腔衛生学会総会, Oct. 2017.
43.	山崎明香, Masami Yoshioka, 板東高志 and Daisuke Hinode : 透析患者における現在歯数および咬合支持状態と標準化蛋白異化率との関連性, 第28回近畿・中国・四国口腔衛生学会総会, Oct. 2017.
44.	森山聡美, 河原林啓太, 杉本明日菜, 赤澤友基, Daisuke Hinode and Tsutomu Iwamoto : 生活習慣に基づく歯科保健指導と生活支援のあり方, 第1回徳島県地域包括ケアシステム学会学術集会, Aug. 2017.
45.	岡本知美, Masami Yoshioka, Harumi Sakamoto, Daisuke Hinode and Yasuhiko Shirayama : 透析患者の口腔保健を支援するために―患者会でのアンケート調査に基づく支援策の検討―, 第1回徳島県地域包括ケアシステム学会学術集会, Aug. 2017.
46.	Arisa Kurokawa, Hiroko Sugimoto, Miki Satoh, Yuko Yasuhara, Hiromi Nakae, Yukari Shinohara, Hiroki Iga, Daisuke Hinode, 本田壮一 and Tetsuya Tanioka : 慢性疾患を抱える55歳以上の地域在住成人の口腔衛生状態，口腔関連QOL,観光関連QOL睡眠の質との関係, 第255回徳島医学会学術集会, Aug. 2017.
47.	Hiroki Iga, Daisuke Hinode, Yasuhiko Shirayama and Fumiaki Kawano : 歯科衛生士学生を対象に行った高齢者施設の口腔ケアに関する国際的な意識調査, 第36回日本歯科医学教育学会総会および学術大会, Jul. 2017. (Keyword) 歯科衛生士学生 / 口腔ケア / 意識調査
48.	Daisuke Hinode, Masami Yoshioka, Miwa Matsuyama, Fumiaki Kawano, 岡本好史 and Shuji Mori : 後期高齢者の口腔保健状況と医療費・介護給付費との関連, 第2回社会歯科学会総会・学術大会, Jun. 2017.
49.	Natsumi Fujiwara, Tokiko Doi, Hiromi Nakae, Yuka Sogawa, Masami Yoshioka, 高橋侑子, 幸江真杉, Kazumi Ozaki and Daisuke Hinode : 本学歯科衛生学生の病棟口腔ケア臨床実習の取り組みとその効果, 第14回日本口腔ケア学会総会・学術大会プログラム・抄録集, 208, Apr. 2017.
50.	Tokiko Doi, Daisuke Hinode, Hiromi Nakae, Masami Yoshioka, 薮内さつき, 福島襄, 阿部昭人 and Masanori Nakano : 学校歯科保健支援ICTシステムを用いた学校歯科保健活動, 第79回全国学校歯科保健研究大会, Nov. 2016.
51.	岡澤悠衣, Daisuke Hinode, Tokiko Doi and Masami Yoshioka : 喫煙者の口臭と唾液中に検出される口腔細菌の特徴, 第11回日本禁煙学会学術総会, Oct. 2016.
52.	Masami Yoshioka, 岡本好史, 村田昌弘, 岸彰, 米田勉 and Daisuke Hinode : メタボリックシンドロームと口腔内状態の関連性-徳島県南部地域における医科歯科連携事業受診者のデータ解析結果より-, 第27回近畿・中国・四国口腔衛生学会総会, Oct. 2016.
53.	森山聡美, 岡澤悠衣, Masami Yoshioka, Yuka Sogawa, Hiromi Nakae, Tokiko Doi, Hiroki Iga and Daisuke Hinode : 食道がん化学療法患者への漢方薬応用の有効性, 第26回近畿・中国・四国口腔衛生学会総会, Oct. 2016.
54.	Harumi Sakamoto, Daisuke Hinode, Masami Yoshioka, 阿部昭人, 岡本好史, 下村学 and 松本侯 : 徳島県における妊婦を対象とした歯科保健事業とその効果, 日本歯科衛生学会第11回学術大会 2016年9/17日~19日広島県広島市広島国際会議場, Sep. 2016.
55.	Natsumi Fujiwara, Hiromi Nakae, Masami Yoshioka, Yuka Sogawa, 高橋侑子, 田口侑子, Akari Watanabe, Tokiko Doi, Kazumi Ozaki and Daisuke Hinode : 某大学における周術期口腔機能管理の臨床実習の取り組みとその効果, 日本歯科衛生学会第11回学術大会 2016年9/17日~19日広島県広島市広島国際会議場, Vol.11, No.1, 174, Sep. 2016.
56.	埴岡隆, 小島美樹, 青山旬, 川口陽子, Daisuke Hinode, 尾崎哲則, 尾崎哲則, 山中玲子, 瀬川洋, 細見環 and 田野ルミ : WHO簡易タバコ介入(5As, ARs)の歯科臨床への統合のための臨床実習資源方法の開発, 第35回日本歯科医学教育学会, Jul. 2016.
57.	Masami Yoshioka, Takashi Bando, Shizuko Yanagisawa and Daisuke Hinode : 透析患者の歯科受診を推進するためのツールとしての医療職および患者向け媒体の作成, 第1回社会歯科学会総会・学術大会, Jun. 2016.
58.	岡澤悠衣, Daisuke Hinode, Tokiko Doi, Hiromi Nakae, Masaaki Yokoyama, Kanako Tamatani and Masami Yoshioka : 舌苔中の歯周病関連細菌に対する喫煙の影響について, 第65回日本口腔衛生学会・総会, May 2016.
59.	高橋侑子, 山崎ほのか, Daisuke Hinode, Harumi Sakamoto, 武川香織, 幸江真杉, Yuka Sogawa, 森山聡美, Tokiko Doi, Hiromi Nakae, Masami Yoshioka and Fumiaki Kawano : 両親学級参加妊婦の口腔保健行動に関するアンケート調査, 第65回日本口腔衛生学会・総会, May 2016.
60.	Hiromi Nakae, 薮内さつき, Natsumi Fujiwara, Shizuko Yanagisawa, Masami Yoshioka, Kaya Yoshida, Yuko Takeuchi, Akari Watanabe, Tokiko Doi, Miwa Matsuyama, Hiroki Iga, Kazumi Ozaki, Daisuke Hinode, Masanori Nakano and Yasuhiko Shirayama : 健口体操ポスターを活用した口腔機能向上の取り組み, 第13回日本口腔ケア学会総会・学術大会, Apr. 2016.
61.	Masami Yoshioka, 中野敦子, 橋本寛文, Yasuhiko Shirayama, Shizuko Yanagisawa, Yuko Takeuchi and Daisuke Hinode : 透析患者の口腔管理に関する意識調査, 第13回日本口腔ケア学会総会・学術大会, Apr. 2016.
62.	Masami Yoshioka, 有川沙絢 and Daisuke Hinode : 歯科専門職の立場から考える若い親世代への禁煙指導, 第61回四国公衆衛生学会総会・平成27年度四国公衆衛生研究発表会, Feb. 2016.
63.	Tokiko Doi, Daisuke Hinode, Hiromi Nakae, Masami Yoshioka, 藪内さつき, 福島襄, 阿部昭人 and Masanori Nakano : 学校歯科保健支援ICTシステムを用いた学校歯科保健活動, 第79回全国学校歯科保健研究大会, Oct. 2015.
64.	森山聡美, Masami Yoshioka, Yuka Sogawa, Hiromi Nakae, Tokiko Doi, Hiroki Iga and Daisuke Hinode : 食道がん化学療法患者に対するがん支持療法としての専門的口腔ケアの効果, 第26回近畿・中国・四国口腔衛生学会総会, Sep. 2015.
65.	Harumi Sakamoto, Daisuke Hinode, Masami Yoshioka, 阿部昭人, 豊仁秋田, 岡本好史, 下村学 and 松本侯 : プレママ教室参加者の口腔保健に関する意識調査, 第26回近畿・中国・四国口腔衛生学会総会, Sep. 2015.
66.	岡澤悠衣, 野々瀬莉加, Daisuke Hinode, Tokiko Doi, Hiromi Nakae, Kanako Tamatani, Masami Yoshioka and 米津隆仁 : 幼児のフッ化物配合歯磨剤の使用状況, 第26回近畿・中国・四国口腔衛生学会総会, Sep. 2015.
67.	Masami Yoshioka, Takashi Bando, 横田成司, Nozomi Yokoyama and Daisuke Hinode : 透析患者の歯科受診推進のための介入策の検討-医療職および患者向け指導用媒体の作成-, 第26回近畿・中国・四国口腔衛生学会総会, Sep. 2015.
68.	Hiromi Nakae, Natsumi Fujiwara, Hiroki Iga, Masami Yoshioka and Daisuke Hinode : 全人的医療を支援する歯科衛生士教育としての病棟実習の取り組みとその効果, 第34回日本歯科医学教育学会総会および学術大会鹿児島市, Jul. 2015.
69.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Hiroki Iga, Kazumi Ozaki, Yasuhiko Shirayama, Miwa Matsuyama, Masami Yoshioka, Shizuko Yanagisawa, Natsumi Fujiwara, Akari Watanabe, Tokiko Doi, Fumiaki Kawano and Katsuhiko Yoshimoto : 歯学部学生の情動知能に対する高齢者交流学習の効果, 第34回日本歯科医学教育学会総会および学術大会鹿児島市, Jul. 2015.
70.	Yuka Sogawa, Masami Yoshioka and Daisuke Hinode : 自家末梢血幹細胞移植患者の口腔粘膜炎に対する専門的口腔ケアの効果, 第12回日本口腔ケア学会総会・学術大会, Jun. 2015.
71.	森山聡美, Masami Yoshioka, 村上愛由, 森下幸, Yuka Sogawa, Hiromi Nakae, Tokiko Doi, Hiroki Iga and Daisuke Hinode : 食道がん化学療法患者の全身状態・栄養摂取状況と口腔粘膜炎との関連性, 第12回日本口腔ケア学会総会・学術大会, Jun. 2015.
72.	Hiromi Nakae, Masami Yoshioka, 薮内さつき, Tokiko Doi, Natsumi Fujiwara, Hiroki Iga and Daisuke Hinode : 回復期病院職員が抱える口腔ケアについての悩みー他職種へのアンケート調査よりー, 第12回日本口腔ケア学会総会・学術大会, Jun. 2015.
73.	Masami Yoshioka, Shizuko Yanagisawa and Daisuke Hinode : 人工透析実施医療機関での医科歯科連携の実態調査, 第60回日本透析医学会学術集会・総会, Jun. 2015.
74.	Tokiko Doi, Hiromi Nakae, 岡澤悠衣, Daisuke Hinode, Masami Yoshioka, Kanako Tamatani, Miwa Matsuyama and 福島襄 : 小学校低学年における口腔衛生習慣および食・生活習慣の状況, 第64回日本口腔衛生学会・総会, Vol.65, No.3, 208, May 2015.
75.	Masami Yoshioka, Issei Imoto, Yasuhiko Shirayama, Shizuko Yanagisawa, 金川裕子 and Daisuke Hinode : 歯科併設のない人工透析実施医療機関における医科歯科連携, 第64回日本口腔衛生学会・総会, May 2015.
76.	Yumi Kuwamura, 澄川真珠子, Hiromi Murata, 瀧川稲子, 大和光, 石田伸子, 菊井聡子, Yasuhiro Hamada, Hirokazu Ito, Yuko Yasuhara, Daisuke Hinode, Hirokazu Uemura, Ken-ichi Aihara, Munehide Matsuhisa, Tetsuya Tanioka and Toshihiko Nagata : 多職種協働での糖尿病患者の口腔保健行動支援:口腔保健行動を査定するための査定シート案についての糖尿病看護の専門家の評価と実施状況, Journal of the The Japan Diabetes Society, Vol.58, No.supplement 1, S290, May 2015. (Keyword) diabetes / oral health behaviors / nursing
77.	Harumi Sakamoto, 武川香織, 幸江真杉, 高橋侑子, Yuka Sogawa, 森山聡美, Tokiko Doi, Hiromi Nakae, Masami Yoshioka, Daisuke Hinode and Fumiaki Kawano : 妊娠期の口腔内状態と低体重児出産との関連性について, 第60回四国公衆衛生学会総会平成26年度四国公衆衛生研究発表会, Feb. 2015.
78.	森山聡美, Masami Yoshioka, 村上愛由, Yuka Sogawa, Hiromi Nakae, Tokiko Doi, Daisuke Hinode and Hiroki Iga : 食道がん周術期患者の口腔内状態について, 第60回四国公衆衛生学会総会平成26年度四国公衆衛生研究発表会・高松, Feb. 2015.
79.	Ray S. Furuya, 齋藤隆仁, keiji Ido, Takayoshi Miyazaki, Kazuhiko Aiba, Norikazu Miyoshi, Hideo Araki, Daisuke Hinode, Katsuhiko Yoshimoto and Namie Sasaki : 徳島大学における「大学入門講座・読書レポート2014」の試み:読書からアカデミック・ライティングへ-, 平成26年度 FD推進プログラム大学教育カンファレンス in 徳島, Dec. 2014.
80.	Ray S. Furuya, Takahito Saito, keiji Ido, Takayoshi Miyazaki, Kazuhiko Aiba, Norikazu Miyoshi, Hideo Araki, Daisuke Hinode and Namie Sasaki : 徳島大学における「大学入門講座・読書レポート2014」の試み, 平成26年度全学FD 徳島大学教育カンファレンスin徳島, 14-15, Dec. 2014. (Keyword) 大学入門講座 / 読書レポート / 新入生 / 附属図書館
81.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Kazumi Ozaki, Yasuhiko Shirayama, Miwa Matsuyama, Shizuko Yanagisawa, Masami Yoshioka, Kaya Yoshida, Natsumi Fujiwara, Akari Watanabe, Tokiko Doi, Masanori Nakano, Fumiaki Kawano and Katsuhiko Yoshimoto : 地域育成型歯学教育プログラムの評価(第2報)地域福祉体験学習における教育効果の変化, 平成26年度FD推進プログラム大学教育カンファレンスin徳島, 62-63, Dec. 2014.
82.	Hiromi Nakae, Daisuke Hinode, 森山聡美, Tokiko Doi, Masami Yoshioka and Hiroki Iga : 脳血管障害患者と健常者の舌苔中における細菌叢についての比較検討, 第25回近畿・中国・四国口腔衛生学会総会・神戸, Oct. 2014.
83.	Harumi Sakamoto, Daisuke Hinode, Masami Yoshioka, 喜来浩子, 藤川貴代, 豊仁秋田, 岡本好史, 下村学 and 松本侯 : 妊娠期の定期歯科健康診査の重要性, 第25回近畿・中国・四国口腔衛生学会総会, Oct. 2014.
84.	Kaya Yoshida, Masami Yoshioka, Hirohiko Okamura and Daisuke Hinode : 大黄甘草湯は活性酸素やインフラマソームを介して5-fluorouracilが誘導する細胞死を改善させる, 第56回歯科基礎医学会学術大会・総会, Sep. 2014.
85.	Yumi Hoshimo, 溝部潤子, 中道敦子, Akari Watanabe, Natsumi Fujiwara, Kazumi Ozaki, Daisuke Hinode, Hiroki Iga, 岩城重次 and 菅武雄 : 口腔ケアシミュレータを応用したリカレント教育の試み -学生実習との比較- ・北九州, 第33回日本歯科医学教育学会, Jul. 2014.
86.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Hiroki Iga, Kazumi Ozaki, Yasuhiko Shirayama, Miwa Matsuyama, Shizuko Yanagisawa, Masami Yoshioka, Yumi Hoshimo, Natsumi Fujiwara, Akari Watanabe, Fumiaki Kawano and Katsuhiko Yoshimoto : 高齢者交流学習後の歯学部生の高齢者イメージの変化・北九州, The Journal of Japanese Dental Education Association, 105, Jul. 2014.
87.	Harumi Sakamoto, Daisuke Hinode, Masami Yoshioka, 岡本好史, 下村学 and 松本侯 : 産科医院でのプレママ教室開催による口腔保健の推進, Journal of Dental Health, Vol.64, No.2, 246, May 2014.
88.	Hiromi Nakae, Tokiko Doi, Daisuke Hinode, Yumi Hoshimo, Masami Yoshioka, Kanako Tamatani, Miwa Matsuyama and 福島譲 : 学校保健における咀嚼の重要性に着眼した食育介入の効果, Journal of Dental Health, Vol.64, No.2, 224, May 2014.
89.	野々瀬莉加, 森山聡美, 岡澤悠衣, Daisuke Hinode, Masami Yoshioka and 米津隆仁 : 幼児のフッ化物配合歯磨剤の利用状況の変化-2010年調査と2013年調査との比較から-, Journal of Dental Health, Vol.64, No.2, 216, May 2014.
90.	Masami Yoshioka, Takashi Bando, 横田成司, 森山聡美, Daisuke Hinode and Yasuhiko Shirayama : 透析患者の歯科受診・受療行動に影響を及ぼす環境因子の検討, Journal of Dental Health, Vol.64, No.2, 233, May 2014.
91.	Yuka Sogawa, Masami Yoshioka, Yoko Abe, 武川香織 and Daisuke Hinode : 造血幹細胞移植患者の口腔粘膜炎に関する因子の分析, Journal of Dental Health, Vol.64, No.2, 167, May 2014.
92.	Tokiko Doi, Hiromi Nakae, Daisuke Hinode, Masami Yoshioka and 隆仁米津 : 学校給食における残食の要因分析, Journal of Shikoku Public Health Society, Vol.59, No.1, 37, Feb. 2014.
93.	Yumi Hoshimo, Atsuko Nakamichi, 管武雄, Akari Watanabe, Natsumi Fujiwara, Miwa Matsuyama, Kazumi Ozaki, 岩城重次, Daisuke Hinode and Hiroki Iga : 歯科衛生士学生を対象とした新しい口腔ケア教育の取り組み-口腔ケアシミュレータを応用したケア実習の効果-, 日本歯科衛生教育学会雑誌, Vol.14, No.2, 109, Dec. 2013. (Keyword) 歯科衛生士教育 / 口腔ケア / シミュレータ
94.	土井登紀子, Daisuke Hinode, Hiromi Nakae, Masami Yoshioka, Hiroki Iga and 薦田淳司 : 高校生の生活習慣・食習慣と肥満との関連性, 第24回近畿・中国・四国口腔衛生学会, Oct. 2013. (Keyword) 生活習慣病 / 肥満
95.	秋山恭子, 遠藤圭子, Daisuke Hinode, 天野秀昭, 日下和代, 藤原愛子, 三阪美恵, 秋房住郎, 木下淳博 and 品田佳世子 : 歯科衛生学生の生活に影響を与える因子調査 ―進路希望に関して―, 日本歯科衛生学会第10回学術大会, Sep. 2013.
96.	石川久子, Hiromi Nagai, Yuka Sogawa, Masami Yoshioka, Daisuke Hinode, Masayuki Azuma and Fumiaki Kawano : 大学病院を拠点とした医科歯科地域連携の取り組みと活動状況, 日本歯科衛生学会第8回学術大会, Sep. 2013.
97.	Yumi Kuwamura, 松田宣子, Ayako Tamura, Takako Ichihara, Takako Minagawa, hikari yamato, Akiyo Kanazawa, Ken-ichi Aihara, kiyoe kurahashi, Sumiko Yoshida, Masami Yoshioka, Daisuke Hinode, Munehide Matsuhisa and Akio Kuroda : 糖尿病患者の口腔保健行動に及ぼす影響要因の検討―第1報口腔保健行動に対する認識との関係から―, 第56回日本糖尿病学会年次学術集会, Vol.56, No.Supplement 1, S-167, May 2013.
98.	Hiromi Nakae, Daisuke Hinode, 平島美穂 and Masami Yoshioka : 歯科専門職と他職種との協働による脳血管疾患患者の口腔ケアの効果, 第62回日本口腔衛生学会・総会, May 2013.
99.	土井登紀子, Daisuke Hinode, Hiromi Nakae, Kanako Tamatani, Miwa Matsuyama and Masami Yoshioka : 小学生児童に対する食育「噛ミング30学習」の効果について, 第62回日本口腔衛生学会・総会, Vol.63, No.2, 171, May 2013.
100.	Masami Yoshioka, Kanako Tamatani, Yuka Sogawa, Masaaki Yokoyama and Daisuke Hinode : 入院患者の口腔乾燥状態の評価とこれに関連する因子の解析, 第62回日本口腔衛生学会・総会, May 2013.
101.	Kazumi Ozaki, 那賀川明美, Masanori Nakano, Yasuhiko Shirayama, Miwa Matsuyama, Daisuke Hinode, Masaru Hada, Masami Yoshioka, Atsuko Nakamichi, Kaya Yoshida, Yuko Takeuchi, Yumi Hoshimo, Natsumi Fujiwara, Hiromi Nakae, 薮内さつき, Hiroki Iga, Fumiaki Kawano and Tetsuo Ichikawa : 社会福祉施設での訪問口腔ケアを支援する包括ケア型地域ICTシステムについて, 第22回日本歯科医学会総会プログラム・事前抄録集, 163, Nov. 2012.
102.	Yumi Hoshimo, Atsuko Nakamichi, Shigetsugu Iwaki, Takeo Suga, Yayoi Kanehisa, Daisuke Hinode and Kazumi Ozaki : development and evaluation of a novel oral hygiene simulator for dental hygienists education, The Journal of Japan Societty of Dental Hygiene Education, Vol.3, No.1, 63, Nov. 2012. (Keyword) Professional Oral Heaalth Care / OralCcare Simulator / Education for Dental Hygienists
103.	Yumi Hoshimo, Atsuko Nakamichi, Takeo Suga, Shigetsugu Iwaki, Yayoi Kanehisa, Daisuke Hinode and Kazumi Ozaki : The Educational Effects of Practice for Skill Acquirement of Oral Care with a Novel Simulator on a Ventilator, The Journal of Japan Societty of Dental Hygiene Education, Vol.3, No.1, 78, Nov. 2012. (Keyword) Professional Oral Heaalth Care / OralCcare Simulator / Education for Dental Hygienists
104.	土井登紀子, Daisuke Hinode, Hiromi Nakae, 天羽崇, Masami Yoshioka, Hiroki Iga and 福島襄 : 歯と口の健康づくりに関する学習の効果について, 第23回近畿・中国・四国口腔衛生学会総会, Oct. 2012.
105.	Yuka Sogawa, 武川香織, 岡田侑子, 真杉幸江, 廣瀬薫, 横山正明, Masami Yoshioka, Daisuke Hinode and Hiroki Iga : 造血幹細胞移植患者の口腔粘膜炎に関する研究, 第23回近畿・中国・四国口腔衛生学会総会, Oct. 2012.
106.	天羽崇, Daisuke Hinode, 平島美穂, Masami Yoshioka, Masaaki Yokoyama, Kanako Tamatani, Makoto Fukui, Hiro-O Ito and Kosuke Kataoka : 舌苔中の歯周病関連細菌と口臭との関連性, 第23回近畿中国四国口腔衛生学会総会, Oct. 2012.
107.	Masami Yoshioka, Daisuke Hinode and Hiroki Iga : 食道がん周術期における口腔内環境の変化, 第60回NPO法人日本口腔外科学会中国・四国地方部会, Oct. 2012.
108.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Kazumi Ozaki, Masaru Hada, Yasuhiko Shirayama, Miwa Matsuyama, Masami Yoshioka, Atsuko Nakamichi, Yumi Hoshimo, Natsumi Fujiwara, Masanori Nakano, Fumiaki Kawano and Katsuhiko Yoshimoto : 高齢社会を担う地域育成型歯学教育:専門教育終了時の授業アンケートから考察される教育効果, 第31回日本歯科医学教育学会総会および学術大会プログラム・抄録集, 124, Jul. 2012.
109.	Hiromi Nakae, Daisuke Hinode, 一宮斉子, 天羽崇, 平島美穂, Masami Yoshioka, Hiroki Iga, Fumiaki Kawano and 福島大輔 : 脳血管障害患者への専門的口腔ケア介入の効果, 第9回日本口腔ケア学会総会学術大会プログラム・抄録集, 97, Jun. 2012. (Keyword) 脳血管障害 / 口腔ケア
110.	Yumi Hoshimo, Keiji Murakami, Katsuhiko Hirota, Daisuke Hinode and Yoichiro Miyake : イグサ粉末の口腔細菌に対する効果, 四国歯学会第40回例会, Mar. 2012.
111.	藤原愛一郎, 桑村肇, 松木倫和, 荒木哲也, 阿部直樹, 坂井田康彦, 豊嶋健治, Masami Yoshioka and Daisuke Hinode : 香川県・高齢者の残存歯数と歯の健康に関する実態調査報告, 香川県歯科医学大会, Feb. 2012.
112.	Masami Yoshioka, 中江弘美, 一宮斉子, Masaaki Yokoyama, Fumiaki Kawano and Daisuke Hinode : 脳卒中患者の地域連携を強化した専門的口腔ケア継続システムに関する研究-急性期脳卒中患者家族のアンケート調査結果より-, 第23年度四国公衆衛生研究発表会, Feb. 2012.
113.	福田ゆか, 福島大輔, 中江弘美, 一宮斉子, 森下幸, Masami Yoshioka and Daisuke Hinode : 脳梗塞により摂食・嚥下障害を呈し専門的口腔ケアを維持した1症例, 第2回徳島県言語聴覚学会, Jan. 2012.
114.	Kikuko Okuda, Daisuke Hinode, Masami Yoshioka, Kumiko Miyazaki and Kyoko Kajiwara : 養護教諭および歯科衛生士養成における多職種連携教育の試み, 平成23年度全学FD 大学教育カンファレンスin徳島, Jan. 2012.
115.	中江弘美, 薮内さつき, Daisuke Hinode, Hiroki Iga, Fumiaki Kawano and Katsuhiko Yoshimoto : 学外体験学習における教育管理システムの運用とその効果, 平成23年度全学FD大学教育カンファレンス in 徳島, Jan. 2012.
116.	Masami Yoshioka, Masaaki Yokoyama, 中江弘美, 一宮斉子, Harumi Sakamoto, 薫廣瀬, Yuka Sogawa, 幸江真杉, 武川香織, Natsumi Fujiwara, Atsuko Nakamichi and Daisuke Hinode : 急性期の脳卒中患者に対する専門的口腔ケアについてのアンケート, Journal of Dental Health, Vol.61, No.4, 460, Oct. 2011.
117.	木村知美, 岡田侑子, 高橋侑子, Masami Yoshioka and Daisuke Hinode : トロミ調整食品のテクスチャーおよび口腔内残留の評価, 第22回近畿・中国・四国口腔衛生学会総会抄録集, 21, Oct. 2011.
118.	中江弘美, 一宮斉子, 福島大輔, 天羽崇, Masami Yoshioka, Hiroki Iga and Daisuke Hinode : 脳卒中患者の口腔状態と専門的口腔ケアによる効果, 第22回近畿・中国・四国口腔衛生学会総会抄録集, 20, Oct. 2011.
119.	武川香織, 幸江真杉, Yuka Sogawa, Harumi Sakamoto, Makoto Fukui, Kosuke Kataoka, Masami Yoshioka and Daisuke Hinode : 妊婦歯科健康診査受診者の妊娠中の歯周状態と出産の状況について, 第22回近畿・中国・四国口腔衛生学会総会抄録集, 19, Oct. 2011.
120.	野々瀬莉加, 米津隆仁 and Daisuke Hinode : 幼児期のフッ化物配合歯磨剤の効果的利用に関する調査, 第22回近畿・中国・四国口腔衛生学会総会, Oct. 2011.
121.	Yumi Hoshimo, Atsuko Nakamichi, Natsumi Fujiwara, Masami Yoshioka and Daisuke Hinode : 歯科衛生士学生に対するプロービング用顎模型を応用した実習の教育効果について, The Journal of Japan Society for Dental Hygiene, Vol.6, No.1, 106, Sep. 2011.
122.	Kaya Yoshida, Hirohiko Okamura, Yumi Hoshimo, Masami Yoshioka and Daisuke Hinode : GSK-3bを介したPKRの骨芽細胞分化調節機構について, 第29回日本骨代謝学会学術集会, Jul. 2011.
123.	Daisuke Hinode, 薮内さつき, 中江弘美, Hiroki Iga, Fumiaki Kawano and Katsuhiko Yoshimoto : 地域育成型歯学教育を推進するための教育管理ネットワークシステムの構築とその活用, 第30回日本歯科医学教育学会総会・学術大会および記念大会, Jul. 2011.
124.	中江弘美, Daisuke Hinode, 薮内さつき, 伊賀弘起, 吉岡昌美, 中野雅徳, 尾崎和美, 羽田勝, 中道敦子 and 河野文昭 : 通所介護施設利用者の口腔環境と口腔機能の状況に関する予備的調査, 第8回日本口腔ケア学会学術大会, Jun. 2011.
125.	薮内さつき, 中江弘美, Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Masanori Nakano, Hideo Yoshida, Masaru Hada, Kazumi Ozaki, Masami Yoshioka, Kaya Yoshida, Atsuko Nakamichi, Yumi Hoshimo, Natsumi Fujiwara, Fumiaki Kawano and Katsuhiko Yoshimoto : 徳島大学教育GP「高齢社会を担う地域育成型歯学教育」授業アンケートから考察される教育効果, 平成22年度全学FD大学教育カンファレンス in 徳島, Jan. 2011.
126.	中江弘美, Daisuke Hinode, 薮内さつき, Hiroki Iga, Masami Yoshioka, Masanori Nakano, Hideo Yoshida, Kazumi Ozaki, Masaru Hada and Atsuko Nakamichi : 地域高齢者との福祉体験学習の教育効果と地域貢献事業としての評価, 第7回日本口腔ケア学会学術大会, Nov. 2010.
127.	Masami Yoshioka, Masaaki Yokoyama, 裕美藤井, Yuka Sogawa, 薫廣瀬, Harumi Sakamoto, 幸江真杉, Kanako Tamatani, Nozomi Yokoyama and Daisuke Hinode : 病院内でのシームレスな専門的口腔ケアの検討, Journal of Dental Health, Vol.60, No.4, 536, Oct. 2010.
128.	Daisuke Hinode : -健康長寿教室として展開する地域育成型歯学教育-, 平成22年度徳島大学歯学部教育GP口腔保健県民公開フォーラム, Sep. 2010.
129.	薮内さつき, Hiroki Iga, 中江弘美, Daisuke Hinode, Masanori Nakano, Hideo Yoshida, Masaru Hada, Kazumi Ozaki, Masami Yoshioka, Atsuko Nakamichi, Yumi Hoshimo, Fumiaki Kawano and Katsuhiko Yoshimoto : 「人間力の向上」を目指した教育プログラム-「高齢者交流学習」-, 第29回日本歯科医学教育学会, Jul. 2010.
130.	Daisuke Hinode, 中江弘美, Masaaki Yokoyama, Masami Yoshioka and Hiroki Iga : 徳島大学歯学部での口腔機能向上をテーマとした地域福祉体験学習の取り組み, 第21回近畿・中国・四国口腔衛生学会総会, Jun. 2010.
131.	Hiroki Iga, Masanori Nakano, Daisuke Hinode, Kazumi Ozaki, Hisahiro Takeuchi, Katsuhiko Yoshimoto and Yoshio Hayashi : 口腔保健学を基軸とした国際的社会福祉教育プログラムの構築に向けて, 平成21年度全学FD 徳島大学教育カンファレンス, Mar. 2010.
132.	中江弘美, Daisuke Hinode, 薮内さつき, Yuko Takeuchi, Hiroki Iga, Masanori Nakano, Hideo Yoshida, Masaru Hada, Kazumi Ozaki, Masami Yoshioka, Atsuko Nakamichi, Yumi Hoshimo, Naoko Matsumoto, Fumiaki Kawano and Katsuhiko Yoshimoto : 地域育成型歯学教育プログラムの評価 -地域福祉体験学習の取り組みを通して-, 平成21年度全学FD 徳島大学教育カンファレンス, Mar. 2010.
133.	Masami Yoshioka, Naoko Matsumoto, 中江弘美, Daisuke Hinode, Hiroki Iga, Fumiaki Kawano and Takafumi Noma : Carrer advancement through inter-disciplinary collaborative learning with the graduate school students of human nutrition, 第28回日本歯科学医学教育学会, Nov. 2009.
134.	Daisuke Hinode, 中江弘美, Hiroki Iga, Masanori Nakano, Hideo Yoshida, Masaru Hada, Kazumi Ozaki, Masami Yoshioka, Atsuko Nakamichi, Yumi Hoshimo, Naoko Matsumoto, Fumiaki Kawano and Katsuhiko Yoshimoto : 「高齢社会を担う地域育成型歯学教育」—地域福祉体験学習の取り組みと教育効果—, 第28回日本歯科医学教育学会総会および学術大会, Nov. 2009.
135.	薮内さつき, Yuko Takeuchi, Masami Yoshioka and Daisuke Hinode : 人間力の向上をめざした徳島大学歯学部での初年次教育カリキュラムの教育効果, 第5回大会社会福祉士教育学会, Nov. 2009.
136.	Yuka Sogawa, Masaaki Yokoyama, 幸江真杉, Harumi Sakamoto, Makoto Fukui, Nozomi Yokoyama, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode : 徳島大学病院における妊婦の口腔保健の現状と今後の課題, Journal of Dental Health, Vol.59, No.4, 493, Oct. 2009. (Keyword) enquête
137.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, バータルジャフツェルメグ, Kosuke Kataoka and Hiro-O Ito : フゾバクテリウム反応性唾液sIgA抗体と舌苔との関連性, Journal of Dental Health, Vol.59, No.5, 606-607, Jun. 2009. (Keyword) *Secretory IgA
138.	Masami Yoshioka, Naoko Matsumoto, 中江弘美, Yoko Abe, Masaaki Yokoyama, Kanako Tamatani, 横山希美, Yumi Hoshimo, Hiroki Iga and Daisuke Hinode : NSTと口腔ケアを軸とした体験学習による歯学部学生のキャリア支援教育の試み, Journal of Dental Health, Vol.59, No.5, 606, Jun. 2009. (Keyword) *口腔衛生
139.	Masaaki Yokoyama, 正秋横山, 淳仁中西, 通仁久米, 聡安達, 隆仁米津, 明人和田, Masami Yoshioka and Daisuke Hinode : 妊娠中の喫煙習慣ならびに歯周状態と低体重児出産との関連性, Journal of Dental Health, Vol.59, No.5, 606, Jun. 2009. (Keyword) *喫煙
140.	Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Masanori Nakano, Hideo Yoshida, Masaru Hada, Kazumi Ozaki, Masami Yoshioka, Kaya Yoshida, Yumi Hoshimo, Naoko Matsumoto, Fumiaki Kawano and Katsuhiko Yoshimoto : 高齢社会を担う地域育成型歯学教育 -初年次教育における達成課題-, 平成20年度全学FD 徳島大学教育カンファレンス, Jan. 2009.
141.	Yuko Takeuchi, Masami Yoshioka and Daisuke Hinode : 対人援助職を目指す学生への初年次教育における達成課題, 第4回大会社会福祉士教育学会, Nov. 2008.
142.	淳仁中西, 正秋横山, 通仁久米, 聡安達, 隆仁米津, 明人和田, Masaaki Yokoyama, Masami Yoshioka and Daisuke Hinode : 徳島県における妊婦の口腔保健の現状と低体重児出産との関連性, Journal of Dental Health, Vol.58, No.5, 562, Oct. 2008.
143.	Yuka Sogawa, 幸江真杉, Harumi Sakamoto, Masaaki Yokoyama, Nozomi Yokoyama, Kanako Tamatani, 寿代佐野, Masami Yoshioka and Daisuke Hinode : 妊婦の歯周病予防におけるかかりつけ歯科医院の重要性, Journal of Dental Health, Vol.58, No.5, 558, Oct. 2008.
144.	Masaaki Yokoyama, Masami Yoshioka, 裕美藤井, Naoko Matsumoto, Yumi Hoshimo, 薫廣瀬, Nozomi Yokoyama, Kanako Tamatani and Daisuke Hinode : 専門的口腔ケアを行ったICU入室患者の口腔衛生状態の変化と転帰, Journal of Dental Health, Vol.58, No.4, 364, Aug. 2008.
145.	正秋横山, 淳仁中西, 伸幸板東, 聡奈良井, 匡史和田, 聡安達, 通仁久米, 隆仁米津, 明人和田, Masaaki Yokoyama, Masami Yoshioka and Daisuke Hinode : 低体重児と歯周病についての疫学調査, The Journal of the Japan Dental Association, Vol.61, No.5, 529, Aug. 2008.
146.	Masami Yoshioka, Naoko Matsumoto, Yumi Hoshimo, Daisuke Hinode, Hiroki Iga, Masaaki Yokoyama, Tetsuo Ichikawa, Fumiaki Kawano and Takafumi Noma : -, 第27回日本歯学医学教育学会総会及び学術大会, Jul. 2008.
147.	Daisuke Hinode, Masaaki Yokoyama, Makoto Fukui and Masami Yoshioka : 口臭外来受診患者の喫煙状況と口臭に対する喫煙経験の影響, 第2回日本禁煙科学会学術総会, Dec. 2007.
148.	Yumi Hoshimo, Kazumi Ozaki, Naoko Matsumoto, Kaya Yoshida, Masami Yoshioka, Yuko Takeuchi, Hideo Yoshida, Daisuke Hinode, Masanori Nakano, Hiroki Iga and Masaru Hada : 歯科衛生士教育の4年生教育に関するニーズ, 第2回日本衛生士教育学術大会, Nov. 2007.
149.	Yuka Sogawa, Harumi Sakamoto, Masaaki Yokoyama, Makoto Fukui, Nozomi Yokoyama, Kanako Tamatani, 寿代佐野, Masami Yoshioka and Daisuke Hinode : 徳島大学病院における妊婦の口腔保健向上のための取り組み, Journal of Dental Health, Vol.57, No.5, 689, Oct. 2007.
150.	Masami Yoshioka, 裕美藤井, Yuka Sogawa, Harumi Sakamoto, 薫廣瀬, Makoto Fukui, Masaaki Yokoyama and Daisuke Hinode : 急性期病院の脳神経外科/神経内科病棟および脳卒中センターにおける専門的口腔ケアのニーズ, Journal of Dental Health, Vol.57, No.4, 569, Aug. 2007.
151.	Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito : 口臭患者における唾液ストレスマーカーの評価, Journal of Dental Health, Vol.57, No.4, 482, Aug. 2007.
152.	Masaaki Yokoyama, Daisuke Hinode, Makoto Fukui, Masami Yoshioka and Hiro-O Ito : 歯周病原細菌Campylobacter rectusと妊娠期の歯周状態との関連性, Journal of the Japanese Association of Periodontology, Vol.49, 176, Aug. 2007.
153.	Masaaki Yokoyama, Daisuke Hinode, Makoto Fukui, Masami Yoshioka and Hiro-O Ito : Relationship between Campylobacter rectus and periodontal status during pregnancy, 「魅力ある大学院教育」イニシアティブ・第1回国際シンポジウム, Mar. 2007.
154.	裕美藤井, 薫廣瀬, Harumi Sakamoto, Yuka Sogawa, Akiko Satoh, Makoto Fukui, Masaaki Yokoyama, Masami Yoshioka and Daisuke Hinode : 徳島大学病院栄養サポートチームにおける専門的口腔ケアの取り組み第2報, Journal of Dental Health, Vol.56, No.5, 723-724, Oct. 2006.
155.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kaname Masuda, Daisuke Hinode and Hiro-O Ito : 学校歯科健診における歯肉炎の評価についての考察, Journal of Dental Health, Vol.56, No.5, 723, Oct. 2006.
156.	Masaaki Yokoyama, Daisuke Hinode, Makoto Fukui, Shin-ichi Tanabe, Masami Yoshioka and Hiro-O Ito : 妊婦における歯周疾患と唾液中の女性ホルモンおよび血管内皮増殖因子(VEGF)の関連性, Journal of Dental Health, Vol.56, No.4, 593, Aug. 2006.
157.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Kanako Tamatani, Nozomi Yokoyama, Masami Yoshioka, 森達哉 and Daisuke Hinode : 口腔ケア活動による介護老人福祉施設職員の意識・行動の変化, Journal of Dental Health, Vol.55, No.5, 630, Oct. 2005.
158.	Makoto Fukui, Masami Yoshioka, Tomoaki Honna, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura : フッ化物洗口実施校におけるう蝕予防効果─歯群別分析および乳歯う蝕と永久歯う蝕の関連性についての分析─, Journal of Dental Health, Vol.55, No.4, 423, Aug. 2005.
159.	Masami Yoshioka, Kaname Masuda, Nozomi Yokoyama, Masaaki Yokoyama, Shin-ichi Tanabe and Daisuke Hinode : Peptostreptococcus microsのサイトカイン産生誘導能に対する酵素の関与, Journal of Dental Health, Vol.55, No.4, 371, Aug. 2005.
160.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Masami Yoshioka and Daisuke Hinode : 要介護高齢者口腔ケア実習に対する歯学部学生の意識調査, 第24回日本歯科医学教育学会総会・学術大会, Jul. 2005.
161.	Shin-ichi Tanabe, Masaaki Yokoyama, Nozomi Yokoyama, Masami Yoshioka and Daisuke Hinode : Smoking and osseointegrated implant failure: a meta-analysis, 52nd Annual Meeting of the Japanese Association for Dental Research, Nov. 2004.
162.	Makoto Fukui, Kaname Masuda, Kanako Tamatani, Tomoaki Honna and Daisuke Hinode : Relationship between periodontal conditions and sIgA directed to microbial GroEL., Journal of Dental Research, Nov. 2004.
163.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani and Daisuke Hinode : 徳島県K村における児童生徒のう蝕罹患状況─10年間のフッ化物洗口の効果と今後の課題─, Journal of Dental Health, Vol.54, No.5, 589, Oct. 2004.
164.	Daisuke Hinode, Makoto Fukui, Shin-ichi Tanabe, Tomoaki Honna, Kaname Masuda and Masami Yoshioka : 歯周病原性細菌 Actinobacillus actinomycetemcomitans 由来 GroELとヒトファイブロネクチンの分子相同性, Journal of Dental Health, Vol.54, No.4, 451, Sep. 2004.
165.	Masaaki Yokoyama, Kaname Masuda, Nozomi Yokoyama, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode : 女性ホルモンが歯周病原細菌Campylobacter rectus及びヒト歯肉線維芽細胞に及ぼす影響, Journal of Dental Health, Vol.54, No.4, 452, Aug. 2004. (Keyword) 女性ホルモン / Campylobacter rectus / ヒト歯肉線維芽細胞
166.	Kaname Masuda, Nozomi Yokoyama, Masami Yoshioka, Shin-ichi Tanabe, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura : Expression of Bradykiin B1 receptor mRNA in Human Gingival Fibroblast, Journal of Dental Research, Vol.82, No.Special Issue C, C-436, Dec. 2003.
167.	Masami Yoshioka, Daniel Grenier, Denis Mayrand, Masaaki Yokoyama, Makoto Fukui, Kanako Tamatani and Daisuke Hinode : Lipopolysaccharides bound to Peptostreptococcus micros induce TNF-α production by U937, 51st Annual Meeting of the Japanese Association for Dental Research, Dec. 2003.
168.	Masaaki Yokoyama, Tomoaki Honna, Kanako Tamatani, Shin-ichi Tanabe, Nozomi Yokoyama, Makoto Fukui, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : 定期的口腔健康管理を受けている者の現在歯数の変化について, Journal of Dental Health, Vol.53, No.5, 618, Oct. 2003.
169.	Masami Yoshioka, Nozomi Yokoyama, Masaaki Yokoyama, Makoto Fukui and Daisuke Hinode : Peptostreptococcus micros によるヒトモノサイトのサイトカイン誘導, Journal of Dental Health, Vol.53, No.4, 618, Sep. 2003.
170.	Makoto Fukui, 赤木毅, Nozomi Yokoyama, Masami Yoshioka, Kanako Tamatani, 嶋田順子, Daisuke Hinode and Ryo Nakamura : 口臭患者における舌苔と唾液中分泌型IgAレベルとの関連性, Journal of Dental Health, Vol.52, No.5, 723, Oct. 2002.
171.	Shin-ichi Tanabe, Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura : 介護老人福祉施設利用者の口腔内状態について, Journal of Dental Health, Vol.52, No.5, 725-726, Oct. 2002.
172.	Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Daisuke Hinode and Ryo Nakamura : 熱ショックタンパク質に対する唾液分泌型IgA抗体と歯周病との関連性, Journal of Dental Health, Vol.52, No.4, 548-549, Aug. 2002.
173.	Masaaki Yokoyama, Shin-ichi Tanabe, Makoto Fukui, Junko Shimada, Kanako Tamatani, Daisuke Hinode and Ryo Nakamura : 骨結合型インプラント治療に対する喫煙の影響, Journal of Dental Health, Vol.51, No.4, 857, Oct. 2001.
174.	Kanako Tamatani, Kaname Masuda, Masaaki Yokoyama, 嶋田順子, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura : Bacteroides forsythusの産生するトリプシン様酵素の性質, Journal of Dental Health, Vol.51, No.4, 548-549, Sep. 2001.
175.	Nozomi Yokoyama, Masami Yoshioka, Shin-ichi Tanabe, Tsuyoshi Akagi, Makoto Fukui, Daisuke Hinode and Ryo Nakamura : ヒト歯肉細胞由来マトリックスメタロプロテアーゼに対する阻害剤の影響, Journal of Dental Health, Vol.51, No.4, 554-555, Sep. 2001.
176.	Masaaki Yokoyama, Daisuke Hinode, Shin-ichi Tanabe, Nozomi Matsuoka, Masami Yoshioka and Ryo Nakamura : Antigenic Property of the GroEL-like Protein from Campylobacter rectus., Journal of Dental Research, Vol.80, No.4, 1333, Apr. 2001.
177.	Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Yukihiro Momota, Masaaki Takechi, Masaru Nagayama, Eiji Yamauchi, Eiichi Bando and Daisuke Hinode : 下顎無歯顎インプラント患者のオトガイ孔後方へのfixture埋入は是か非か?, 第31回日本口腔インプラント学会総会・学術大会, 2001. (Summary) 1
178.	Masami Yoshioka, Tsuyoshi Akagi, Kanako Tamatani, Shin-ichi Tanabe, Masaaki Yokoyama, Nozomi Yokoyama, Yutaka Sato, Daisuke Hinode and Ryo Nakamura : 口臭が気になる患者に対するアプローチ診査，治療の進め方, Journal of Dental Health, Vol.50, No.5, 836, Oct. 2000.
179.	Masaaki Yokoyama, Masami Yoshioka, Kanako Tamatani, Nozomi Matsuoka, 嶋田順子, Daisuke Hinode and Ryo Nakamura : Campylobacter rectus表層抗原物質の性状, Journal of Dental Health, Vol.50, No.4, 494, Sep. 2000.
180.	Tsuyoshi Akagi, Daisuke Hinode, Kaname Masuda, Shin-ichi Tanabe, Makoto Fukui, Masami Yoshioka and Ryo Nakamura : Campylobacter rectus とHelicobacter pylori の共通抗原, Journal of Dental Health, Vol.50, No.4, 592-593, Sep. 2000.
181.	Daisuke Hinode, Shin-ichi Tanabe, Tsuyoshi Akagi, Masaaki Yokoyama, Masami Yoshioka and Ryo Nakamura : 歯周病原性細菌とHelicobacter pyloriの免疫学的関連性, Journal of the Japanese society of periodontology, Vol.42, 159, May 2000.
182.	Seiko Tatehara, Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, 藤武智, 飛梅悟, 増田尚子, Masaru Nagayama, Motoharu Kori, 松浦広輿, Eiji Yamauchi, Kazuo Okura and Daisuke Hinode : 当科におけるブローネマルクインプラントの臨床統計的検討-Osseointegration獲得に関与する因子について-, 第20回日本口腔インプラント学会中国・四国支部総会・学術大会, 2000. (Summary) 1
183.	Masaaki Takechi, Youji Miyamoto, Kenji Fujisawa, Yukihiro Momota, Tetsuya Yuasa, 藤武智, Masaru Nagayama, 鈴木温 and Daisuke Hinode : 当科におけるインプラント失敗例に関する臨床的検討一上部構造装着前の失敗症例について一, 第30回日本口腔インプラント学会総会・学術大会, 2000. (Summary) 1
184.	Kaname Masuda, Tsuyoshi Akagi, Junko Shimada, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Porphyromonas gingivalis の産生するアルギニンカルボキシペプチダーゼの遺伝子解析, Journal of Dental Health, Nov. 1999.
185.	Masami Yoshioka, Kouji Tomita, Osamu Miki, Shin-ichi Tanabe, Jyunko Shimada, Daisuke Hinode, Kumiko Kondou and Ryo Nakamura : 徳島県木頭村の児童生徒に対する歯科保健活動, Journal of Dental Health, Vol.49, No.5, 827, Oct. 1999.
186.	Shin-ichi Tanabe, Osamu Miki, Akiko Sugiyama, Daisuke Hinode and Ryo Nakamura : Campylobacter rectus GroEL様蛋白質の宿主細胞に対する影響, Journal of Dental Health, Vol.49, No.4, 632-633, Sep. 1999.
187.	Shin-ichi Tanabe, Daisuke Hinode, Chiaki Ohtsuka, Akiko Sugiyama and Ryo Nakamura : Purification of the GroEL-like Protein from Campylobacter rectus, Journal of Dental Research, Vol.78, No.5, 1117, May 1999.
188.	Daisuke Hinode, Masami Yoshioka, Kouji Tomita, Shin-ichi Tanabe and Ryo Nakamura : インプラント患者のメインテナンス, Journal of Dental Health, Vol.48, No.5, 720, Oct. 1998.
189.	Masami Yoshioka, Osamu Miki, Shin-ichi Tanabe, Akiko Sugiyama, Daisuke Hinode and Ryo Nakamura : 歯周病原菌の病原因子による細胞毒性活性測定法についての検討, Journal of Dental Health, Vol.48, No.4, 412-413, Sep. 1998.
190.	Shin-ichi Tanabe, Daisuke Hinode, Masami Yoshioka and Ryo Nakamura : Heat shock protein of Campylobacter rectus, Journal of Dental Research, Vol.77, No.5, 1299, May 1998.
191.	Daisuke Hinode, Shin-ichi Tanabe, Chiaki Ohtsuka, Kouji Tomita and Ryo Nakamura : Porphyromonas gingivalis の熱ショック蛋白質, Journal of Dental Health, Vol.47, No.4, 412-413, Sep. 1997.
192.	Daisuke Hinode, Shin-ichi Tanabe, Masami Yoshioka, Daniel Grenier, Denis Mayrand and Ryo Nakamura : Protease activities of non-pigmented mutants of Porphyromonas gingivalis, Journal of Dental Research, Vol.76, No.5, 1174, May 1997.
193.	Daisuke Hinode, Daniel Grenier, Denis Mayrand, Shin-ichi Tanabe, Masami Yoshioka and Ryo Nakamura : 歯周病原性細菌由来のDnaK様蛋白質の免疫学的研究, Journal of Dental Health, Vol.46, No.4, 532-533, Sep. 1996.

Products:

1.	Daisuke Hinode : 歯・口の健康づくりを通じた生活習慣形成を実践する2園の取り組みから, 日本学校歯科医会会誌, Vol.113, 53, 2012.

Et cetera, Workshop:

1.	Kaname Masuda, Shin-ichi Tanabe, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Purification of Characterization of Arginine Carboxypeptidase Produced by Porphyromonas gingivalis, Jul. 2001.

Report:

1.	Hiroki Iga, Daisuke Hinode, RODIS Marianito Maningo Omar, Yasuhiko Shirayama, TOIVANEN-LABIAD Tuula, NUUTINEN Erja, HAARALA Päivi, AHOKAS Aija and Fumiaki Kawano : International Survey Regarding Oral Health Care in Facilities for Elderly in the Dental Hygiene Student Exchange Program, Journal of Oral Health and Biosciences, Vol.31, No.1, 73-77, Jul. 2018. (Summary) <b>Background:</b> In 2010, Tokushima University School of Dentistry concluded an academic agreement with Metropolia University of Applied Sciences (Metropolia UAS), which offers degree programs of oral health in Finland. We have collaborated through the student exchange program to foster the knowledge of future global dental hygienists in both schools. In this study, we carried out a survey on the attitude of the dental hygiene students regarding oral health care in facilities for the elderly to develop a new international education program for dental hygiene students.<br><b>Materials and Methods:</b> The questionnaire on oral health care in facilities for the elderly was given out to the exchange students of Metropolia UAS and students of Tokushima University. Ninety-one (91) dental hygiene students of Metropolia UAS and fifty-six (56) dental hygiene students of Tokushima University participated in this study and statistical analysis were carried out.<br><b>Results:</b> One hundred forty-seven (147) students from both schools participated in the survey. 80.2% of the students from Metropolia UAS and 69.6% of the students from Tokushima University chose "Moderate" and "Bad" to the questions of "What is your opinion about the current state of oral health care in health care facilities for the elderly?". There was no statistically significant difference in the answer to the question "Could you work in a health care facility for the elderly as a dental hygienist?" from students of both schools. There was also a statistically significant difference observed by Chisquared test in the answer of "Do you think that your knowledge of oral health care for the elderly is sufficient?" and the answers of free writing which suggested that Metropolia UAS students have a more positive attitude towards the knowledge of oral health care for the elderly than Tokushima University students.<br><b>Conclusion:</b> The results of this international questionnaire survey suggested that many students of Metropolia UAS can be considered to have enough knowledge of oral health care for elderly when compared with students of Tokushima University. (Keyword) International survey / dental hygiene students / exchange student progra (Tokushima University Institutional Repository) ● Metadata: 111942 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.31.1_73 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845712973232640 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_73 (Tokushima University Institutional Repository: 111942, DOI: 10.20738/johb.31.1_73, CiNii: 1390845712973232640)
2.	Natsumi Fujiwara, Yumi Hoshimo, Mami Sugimoto, Tokiko Doi and Daisuke Hinode : A Report of Participation and Activity in International Week Meeting Held by Helsinki Metropolia University of Applied Sciences, Shikoku Dental Research, Vol.24, No.2, 95-98, Jan. 2012. (Tokushima University Institutional Repository) ● Metadata: 109822 (Tokushima University Institutional Repository: 109822)
3.	兼松登, 中西淳仁, 原友則, 安田勝裕, 浜口博, 米津隆仁, 小笠復夫, 井上秀人, Daisuke Hinode and 那賀川明美 : 徳島県における2歳児歯科健康診査の有用性に関する調査, 四国歯学会誌, Vol.16, No.2, 425-434, Tokushima, Jan. 2004.
4.	Daisuke Hinode, Shin-ichi Tanabe, Masaaki Yokoyama, Masami Yoshioka and Ryo Nakamura : 歯周病原細菌由来熱ショックタンパク質の病原性, Dental Outlook, 384, Tokyo, Aug. 2001.

Patent:

1.	武田健志, 江口徹, Daisuke Hinode and 阿良隆 : 歯周疾患診断用具および歯周疾患原因細菌の検出方法, 2005-238905, .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

家庭・園・歯科協働による幼児の食機能/口腔機能発達に寄与する教育プログラムの開発 (Project/Area Number: 23K09495 )
行動変容を導く保健関連因子の探索と国際的視点での口腔保健アウトカムへの介入効果 (Project/Area Number: 23K09481 )
歯科保健行動への介入を起点とした共通リスクファクターアプローチによるNCDs予防 (Project/Area Number: 21K10246 )
高齢者の肺炎および口臭予防を目的とした新規口腔環境改善手法の確立 (Project/Area Number: 21K10228 )
オーラルフレイル対策を包含したコモンリスクファクターアプローチによる介護予防戦略 (Project/Area Number: 19K10445 )
Elucidation of oral environmental factors involved in adverse events of patients undergoing cancer chemotherapy (Project/Area Number: 19K10432 )
Roles of Fusobacterium nucleatum in Systemic Inflammations by Cancer Chemotherapy (Project/Area Number: 19K08839 )
Establishment of dental health services for pregnant woman aiming to improve health disparities (Project/Area Number: 18K09881 )
Elucidation of oral environmental factors involved in prevention of diabetic nephropathy and development of oral version prevention program (Project/Area Number: 17K12009 )
Estimation of aspiration pneumonia risk using a simple-version assesment sheet for oral care. (Project/Area Number: 17K11791 )
Oral health promotion utilizing the blueberry extract polyphenol as the functional food (Project/Area Number: 16K11860 )
Strategic development of leading dental hygienist with a glocal spirit (Project/Area Number: 15K11449 )
Effectiveness of intervention with food and nutrition education for independent health promotion through the Oral Health Promotion Support Information and Communication Technology System in School (Project/Area Number: 15K11419 )
Development of the diabetes oral health assessment tool for nurses to help the patients with diabetes with their oral health behaviors simply (Project/Area Number: 26463305 )
Study for the effectiveness of muli-professional cooperation on oral healthcare in convalescent hospitals (Project/Area Number: 26463162 )
Construction of obstetrics and dentistry cooperation system to promote oral health for pregnant woman (Project/Area Number: 25670893 )
Elucidation of environmental factors associated with dental visits among hemodialysis patients (Project/Area Number: 25463246 )
The comprehensive support model for higher brain dysfunction due to Medical and Dental of cooperation (Project/Area Number: 24500587 )
Establishment of the medical support to inpatients by oral health management applied with Kampo medicine (Project/Area Number: 24390471 )
Study of nursing oral care model for promotion of oral host defense (Project/Area Number: 23593201 )
Comprehensive research aimed at a development of the supplemental food for swallowing which is oriented toward an oral health (Project/Area Number: 21592651 )
Effectiveness of the continuous professional oral health care in close community-cooperation for patients with cerebral vascular disorder (Project/Area Number: 21390559 )
The effect of professional oral health care on improving autoimmune disease (Project/Area Number: 20390536 )
Study of palliative care about xerostomia in patients on haemodaialysis (Project/Area Number: 19592543 )
Analysis of salivary amino acids associated with physiologichalitosis and investigation of inhbitor against oral malodor (Project/Area Number: 19592407 )
天然ペプチドライブラリーからのカンジダ菌定着抑制物質の検索 (Project/Area Number: 19592406 )
Studies on the practical use of soybean peptides for oral health promotion in the elderly (Project/Area Number: 17592182 )
The research of oral care for increasing host defense (Project/Area Number: 15592234 )
Study on the mechanism of periodontal pocket formation using Matrix Metalloproteinase inhibitors (Project/Area Number: 13672156 )
The prediction of periodontal condition by the measurement of the antibody titers directed to heat shock proteins (Project/Area Number: 12557184 )
Arginine Catabolism and Its Role in Pathogenecity by Periodontopathogenic Bacteria (Project/Area Number: 12470461 )
Campylobacter rectusの熱ショックタンパク質の遺伝子解析 (Project/Area Number: 11877363 )
Host responses against heat shock proteins from periodontopathogenic bacteria (Project/Area Number: 10470447 )
歯周病原細菌の分子シャペロンの機能 (Project/Area Number: 09877359 )
Self Defence Mechanism of Porphyromonas gingivalis and Its Periodontopathogenicity (Project/Area Number: 09470472 )
Characterization of Heat Shock Proteins from Periodontopathogenic Bacteria and Their Virulences (Project/Area Number: 08672372 )
Development of a diagnostic tool for periodontal disease by utilizing the monoclonal antibody directed the specific protease from periodontopathogensis bacteria (Project/Area Number: 06557113 )
A study of multipule factors influencing on the caries incidence of deciduous teeth and permanent teeth. (Project/Area Number: 05671713 )
Development of serotyping reagents for the periodontopathogenic bacterium, Bacteroides (Porphyromonas) gingivalis. (Project/Area Number: 02557082 )
Biologically active substances produced by Bacteroides gingivalis and their periodontopathogenicity (Project/Area Number: 02404078 )
バクテロイデス・ジンジバリスの血清型別特異抗原の分離と性状 (Project/Area Number: 01571124 )
Isolation of collagenase inhibitor from soil bacterium and its application on periodontal disease. (Project/Area Number: 61870077 )
The Effect of Some Serum Components on the Thiol-Dependent Collagenolytic Enzyme Isolated from Bacteroides gingivalis 381. (Project/Area Number: 61570974 )
Purification and characterization of collagenase inhibitory substance in soy-beans which inhibits specifically collagenolytic enzyme from Bacteroides gingivalis. (Project/Area Number: 61480419 )
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Professor : Hinode, Daisuke

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