徳島大学 / 教育研究者総覧 --- 江口覚

個人のホームページ

https://researchmap.jp/read0043199 (researchmap)

専門分野

○	歯学 (Dentistry)

研究テーマ

○

著書・論文

学術論文(審査論文):

1.	西川美佳, 高石和美, 藤原茂樹, 江口覚, 北畑洋, 川人伸次 : 歯科口腔外科手術における高齢患者の麻酔方法と術前合併疾患に関する検討, 臨床麻酔, Vol.48, No.1, 87-89, 2024年.
2.	Mika Nishikawa, Kazumi Takaishi, Marina Takata, Osamu Sasajima, Shigeki Fujiwara Joseph Luke, Satoru Eguchi and Shinji Kawahito : Pronounced QTc Prolongation During General Anesthesia in a Child with Left Ventricular Non-Compaction Cardiomyopathy, Anesthesia Progress, Vol.70, No.3, 137-139, 2023.
3.	西川美佳, 高田真里菜, 篠島理, 髙田香, 藤原茂樹, 江口覚, 高石和美, 川人伸次 : 機器紹介インターサージカル個人防護用呼吸マスク「i-Proマスク」, 循環制御, Vol.43, No.2, 107-108, 2022年.
4.	高田真里菜, 篠島理, 西川美佳, 髙田香, 藤原茂樹, 江口覚, 高石和美, 箕田直治, 曽我朋宏, 木下浩之, 川人伸次 : 複数回の再手術を要し血友病Bと判明した舌裂傷の1症例, 日本小児麻酔学会誌, Vol.28, No.1, 59-61, 2022年.
5.	篠島理, 高田真里菜, 西川美佳, 髙田香, 藤原茂樹, 江口覚, 高石和美, 箕田直治, 曽我朋宏, 木下浩之, 川人伸次 : 下咽頭梨状窩瘻に対しトリクロル酢酸で化学的焼灼術を施行した1症例, 日本小児麻酔学会誌, Vol.29, No.1, 62-64, 2022年.
6.	西川美佳, 高石和美, 髙田真里菜, 篠島理, 藤原茂樹, 江口覚, 川人伸次 : 全身麻酔導入および覚醒時に顕著なQTc延長を認めた左室心筋緻密化障害患児の1例, 日本歯科麻酔学会雑誌, Vol.50, No.2, 70-72, 2022年.
7.	西川美佳, 高石和美, 高田真里菜, 篠島理, 藤原茂樹, 江口覚, 川人伸次 : 全身麻酔導入および覚醒時に顕著なQTc延長を認めた左室心筋緻密化障害患児の1例, 日本歯科麻酔学会雑誌, Vol.50, No.2, 70-72, 2022年. (キーワード) 心筋緻密化障害 / QTc / QT延長 / 非侵襲連続推定心拍出量 / 全身麻酔 / LEFT VENTRICULAR NON-COMPACTION / QT PROLONGATION / CARDIAC OUTPUT / GENERAL ANESTHESIA (出版サイトへのリンク) ● Publication site (DOI): 10.24569/jjdsa.50.2_70 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390291767985240960 ● Search Scopus @ Elsevier (DOI): 10.24569/jjdsa.50.2_70 (DOI: 10.24569/jjdsa.50.2_70, CiNii: 1390291767985240960)
8.	川人伸次, 高石和美, 江口覚, 藤原茂樹, 西川美佳, 髙田真里菜, 篠島理, 木下浩之 : 細胞骨格およびIL-17制御を介した血管内皮機能維持機構の解明と麻酔薬作用, BIO Clinica, Vol.36, No.12, 68-71, 2021年. (キーワード) 細胞骨格 / F-アクチン / IL-17 / 血管内皮機能 / 周術期管理 / サイボウコッカク / ケッカンナイヒキノウ / シュウジュツキカンリ (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520294113669925760 (CiNii: 1520294113669925760)
9.	Atsushi Nishigaki, Takashi Kawano, Hideki Iwata, Bun Aoyama, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M. Locatelli and Masataka Yokoyama : Acute and long-term effects of haloperidol on surgery-induced neuroinflammation and cognitive deficits in aged rats., Journal of Anesthesia, Vol.33, No.3, 416-425, 2019. (要約) Neuroinflammation may contribute to the pathogenesis of the cognitive symptoms of postoperative delirium (POD) and its subsequent long-term cognitive impairment. Haloperidol (HAL), a dopamine receptor antagonist, is widely used to treat POD, whereas the effects of HAL on postoperative neuroinflammation and related cognitive deficits have been underdetermined. Aged rats underwent sham or abdominal surgery and were subcutaneously treated with either vehicle, low-dose (0.5 mg/kg bolus, then 0.5 mg/kg/day infusion), or high-dose (2.0 mg/kg bolus, then 2.0 mg/kg/day infusion) HAL. All treatments were initiated immediately after surgery and continued for 48 h. On either postoperative day 2 (early) or 7 (late), all rats were tested for trace and context fear memory retention after acquisition of trace fear conditioning. Following the cognitive testing, the levels of pro-inflammatory cytokines, as well as dopamine and its metabolite, in hippocampus and medial prefrontal cortex (mPFC) were measured. In the early postoperative period, surgery induced acute neuroinflammation along with related trace and context memory dysfunction. Dopamine turnover was increased in both hippocampus and mPFC, whereas no relationship with memory functions was observed. However, HAL even at high-dose failed to restore the surgery-induced neuroinflammation and related cognitive deficits. In the late postoperative period, chronic neuroinflammation was detected only in hippocampus, which was associated with context, but not trace memory dysfunction. Neither low- nor high-dose HAL could prevent the development of these late-phase neurocognitive deficits. Our findings indicate that perioperative administration with HAL may have no effects on postoperative neuroinflammation and related cognitive impairment. (キーワード) Animals / Cognition / Cognitive Dysfunction / Cytokines / Delirium / Fear / Haloperidol / Hippocampus / 男性 (male) / 記憶 (memory) / Postoperative Period / Rats / Rats, Wistar / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-019-02646-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31049689 ● Summary page in Scopus @ Elsevier: 2-s2.0-85065290095 (DOI: 10.1007/s00540-019-02646-0, PubMed: 31049689, Elsevier: Scopus)
10.	Tsuyoshi Koyama, Takashi Kawano, Hideki Iwata, Bun Aoyama, Satoru Eguchi, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Fabricio M. Locatelli and Masataka Yokoyama : Acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats., Journal of Anesthesia, Vol.33, No.3, 482-486, 2019. (要約) The acute neuroinflammatory response to surgery may play a key pathogenic role in postoperative delirium (POD). Here, we investigated the contribution of acute postoperative pain to neuroinflammation and related delirium-like behaviors after surgery in adult and aged rats. Animals were assigned into four groups: control, abdominal surgery, surgery with analgesia using local ropivacaine, and surgery with analgesia using systemic morphine. Pain was assessed by the Rat Grimace Scale (RGS). Trace and context memory retention was evaluated following trace fear conditioning during the first 2 days after surgery. Pro-inflammatory cytokines in medial prefrontal cortex and hippocampus were measured by enzyme-linked immunosorbent assay. In both age groups, the RGS increased significantly from baseline until 6 h after surgery. The postoperative analgesia with either local or systemic regimens comparably alleviated the RGS increase in adult and aged animals. The two analgesic regimens attenuated the surgery-induced trace and context memory deficits, as well as cytokines overproduction in both medial prefrontal cortex and hippocampus. No age-related differences were found in the neuro-cognitive effectiveness of postoperative analgesia. Our experimental findings provide proof-of-concept for adequate postoperative pain management as one of the main preventive strategies of POD. (キーワード) Acute Pain / Animals / Cognitive Dysfunction / Cytokines / Delirium / Fear / Hippocampus / 男性 (male) / 記憶 (memory) / Memory Disorders / Morphine / Pain, Postoperative / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-019-02635-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30911820 ● Summary page in Scopus @ Elsevier: 2-s2.0-85064056376 (DOI: 10.1007/s00540-019-02635-3, PubMed: 30911820, Elsevier: Scopus)
11.	Bun Aoyama, Takashi Kawano, Hideki Iwata, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M. Locatelli and Masataka Yokoyama : Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats., Journal of Pharmacological Sciences, Vol.139, No.2, 77-83, 2019. (要約) The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were randomly divided into one of three groups; non-exercise control, Low-exercise, and High-exercise. The animals in the Low- and High-exercise groups were subjected to a 10-minute treadmill workout at 40% and 80% maximum oxygen intake intensity, respectively. In the Low-exercise groups, a significant EIH response was observed in aged but not in adult rats. The pre-treatment with ALLO synthesis inhibitor finasteride, but not opioid-receptor antagonist naloxone, inhibited the Low-exercise induced EIH response in aged rats. Furthermore, the Low-exercise increased brain ALLO levels in aged animals compared with controls, which was correlated with the mechanical pain sensitivity. On the other hand, High-exercise could induce EIH response in both adult and aged animals, but it was more effective in adult rats. The pre-treatment with naloxone, but not finasteride, reduced the EIH observed after High-exercise in both adult and aged rats. Our findings demonstrated that effective EIH can be achieved even by mild-intensity exercise in aged animals via an increase of the brain ALLO levels. (キーワード) Aging / Animals / Behavior, Animal / Brain / Male / Pain / Pain Threshold / Physical Conditioning, Animal / Pregnanolone / Progesterone / Rats, Wistar / Reflex / Spinal Cord (徳島大学機関リポジトリ) ● Metadata: 114602 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jphs.2018.11.009 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30579760 ● Search Scopus @ Elsevier (PMID): 30579760 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jphs.2018.11.009 (徳島大学機関リポジトリ: 114602, DOI: 10.1016/j.jphs.2018.11.009, PubMed: 30579760)
12.	山本剛士, 高石和美, 大塚良, 藤原茂樹, 江口覚, 北畑洋 : QTc延長患者における全身麻酔中のQTc変動, 日本歯科麻酔学会雑誌, Vol.47, No.2, 53-55, 2019年. (要約) <p> Long QT syndrome is characterized by a prolongation of the QT interval and a morphological change in the T wave on an electrocardiogram. Prolongation of the QT interval is associated with serious arrhythmia and may cause syncope and sudden death. A 13-year-old male with a prolonged corrected QT interval (QTc) on a preoperative electrocardiogram was scheduled to undergo the extractation of a supernumerary tooth under general anesthesia.</p><p> Although he had no remarkable past medical history, his QTc was prolonged to 514 ms on a 12-lead electrocardiogram. There was no history of syncope or sudden death in his family. The QTc at the time of his entrance into the operation room was 483 ms. During surgery, his QTc was continuously monitored in addition to the usual intraoperative monitoring. After the rapid introduction of anesthesia with remifentanil and propofol, the anesthesia was maintained with remifentanil and sevoflurane in oxygen and air. No significant change in the QTc was observed at the time of tracheal intubation accompanied by sympathetic stimulation. There was also no significant change in the QTc after the administration of atropine for bradycardia. However, when 2% lidocaine containing adrenaline was used for local anesthesia, the QTc gradually became prolonged reaching a maximum of 507 ms. In patients with a prolonged QT interval on a preoperative electrocardiogram, careful attention may be needed during the use of local anesthetics containing adrenaline. In addition, continuous monitoring of the QTc during surgery may be useful for the prevention of serious arrhythmias.</p> (キーワード) QT延長症候群 / QTc延長 / QTc変動 / アドレナリン含有リドカイン (出版サイトへのリンク) ● Publication site (DOI): 10.24569/jjdsa.47.2_53 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390564238083486464 ● Search Scopus @ Elsevier (DOI): 10.24569/jjdsa.47.2_53 (DOI: 10.24569/jjdsa.47.2_53, CiNii: 1390564238083486464)
13.	Yukihiro Momota, Kohichi Kani, Nao Masuda, Satoru Eguchi, Ohtuka Ryo, Hideyuki Takano and Masayuki Azuma : A Case of Well-Managed Fibromyalgia with Autonomic Dysfunction during Dental Therapy: Significance of Heart Rate Variability Analysis, IOSR Journal of Dental and Medical Sciences, Vol.17, No.10, 33-35, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-1710033335 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-1710033335 (DOI: 10.9790/0853-1710033335)
14.	Fabricio M. Locatelli, Takashi Kawano, Hideki Iwata, Bun Aoyama, Satoru Eguchi, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli and Masataka Yokoyama : Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats., Journal of Pharmacological Sciences, Vol.137, No.4, 395-402, 2018. (要約) The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect of resveratrol (RESV) for POCD in aged rats. The emulsified form of RESV (e-RESV) was selected to improve its oral and brain bioavailability. Animals were assigned to one of four groups: e-RESV (80 mg/kg) versus vehicle treatment by abdominal surgery versus isoflurane anesthesia alone (n = 8 in each group). The dose-dependent effects of e-RESV were also assessed in dose range of 0-60 mg/kg. Either vehicle or e-RESV was administered intragastrically 24 h before surgery. Seven days after procedure, cognitive function was evaluated using a novel object recognition test, followed by measurement of hippocampal pro-inflammatory cytokine levels. Our results showed that pre-treatment with e-RESV attenuated the surgery-induced cognitive impairment and related hippocampal neuroinflammation at 40 mg/kg or higher doses. Additionally, the ex-vivo experiments revealed that the preemptive e-RESV regimen reduced the hippocampal microglial immune reactivity to lipopolysaccharide. Furthermore, e-RESV induced neuroprotective benefits were inhibited by the concomitant administration of sirtinol, a specific SIRT1 inhibitor. Our findings imply the preventive potential of e-RESV for POCD via the SIRT1 signaling pathway. (キーワード) Administration, Oral / Aging / Animals / Biological Availability / Cognitive Dysfunction / Cytokines / Dose-Response Relationship, Drug / Emulsions / Hippocampus / Inflammation / Inflammation Mediators / Male / Microglia / Postoperative Complications / Rats, Wistar / Resveratrol / Signal Transduction / Sirtuin 1 / Stilbenes (徳島大学機関リポジトリ) ● Metadata: 114599 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jphs.2018.08.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30196020 ● Search Scopus @ Elsevier (PMID): 30196020 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jphs.2018.08.006 (徳島大学機関リポジトリ: 114599, DOI: 10.1016/j.jphs.2018.08.006, PubMed: 30196020)
15.	Hiroki Tateiwa, Takashi Kawano, Atsushi Nishigaki, Daiki Yamanaka, Bun Aoyama, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M. Locatelli and Masataka Yokoyama : The role of hippocampal brain-derived neurotrophic factor in age-related differences in neuropathic pain behavior in rats., Life Sciences, Vol.197, 56-66, 2018. (要約) This study was aimed to explore the contribution of central brain-derived neurotrophic factor (BDNF) in the neuropathic pain pathogenesis using an aged rodent model. Adult and aged rats were randomly assigned to either a sciatic nerve ligation (SNL) group or a control skin sham surgery group. Sensory behavioral testing were performed on the day before surgery and on the 3rd, 7th, 14th, and 21st days after surgery, followed by measurement of BDNF protein levels in different brain regions. In another experiment, the hippocampal BDNF gene expression after SNL surgery was assessed at different time-points. Furthermore, the analgesic effects of intranasal BDNF administration were tested in SNL animals. Our behavioral results demonstrated that the hyperalgesia-like behavior after painful nerve injury has a higher incidence in aged rats compared with in adult animals. In particular, the hippocampal BDNF levels were inversely correlated with the probability of hyperalgesia-type behavior, in both brain-region specific and age-dependent manner. Time-course analysis showed that the hippocampal levels of BDNF mRNA in aged and adult rats started to decrease 7 and 14 days after surgery, respectively. However, the decrease was more pronounced in aged animals. Moreover, the repeated intranasal BDNF treatment could restore the central BDNF signaling, counteracting the age-related exacerbation of hyperalgesic behavior. Our findings imply that hippocampal BDNF may be related with the pathogenesis of elderly neuropathic pain. Pharmacological data further suggest that brain BDNF may be modifiable in aged neuropathic animals, and therefore, represent a promising target for intervention. (キーワード) Aging / Animals / Behavior, Animal / Brain-Derived Neurotrophic Factor / Gene Expression Regulation / Hippocampus / Male / Neuralgia / RNA, Messenger / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.lfs.2018.01.030 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29409869 ● Search Scopus @ Elsevier (PMID): 29409869 ● Search Scopus @ Elsevier (DOI): 10.1016/j.lfs.2018.01.030 (DOI: 10.1016/j.lfs.2018.01.030, PubMed: 29409869)
16.	藤原茂樹, 大塚良, 尾上真奈美, 江口覚, 高石和美, 北畑洋 : 閉塞型睡眠時無呼吸症候群を伴った成人スティル病患者の嚢胞摘出術における静脈内鎮静法下患者管理の経験, 臨床麻酔, Vol.42, No.2, 220-222, 2018年.
17.	藤原茂樹, 大塚良, 尾上真奈美, 江口覚, 高石和美, 北畑洋 : Stevens-Johnson症候群の既往がある難治性てんかん患者の全身麻酔経験, 臨床麻酔, Vol.41, No.10, 1424-1426, 2017年.
18.	Takashi Kawano, H Iwata, B Aoyama, A Nishigaki, D Yamanaka, H Tateiwa, Satoru Eguchi, FM Locatelli and M Yokoyama : The role of hippocampal insulin signaling on postoperative cognitive dysfunction in an aged rat model of abdominal surgery., Life Sciences, Vol.162, 87-94, 2016. (要約) This study aimed to investigate the role of central insulin signaling, including glycogen synthase kinase 3β (GSK-3β), and its therapeutic potential for the prevention of postoperative neurocognitive deficits. In non-insulin experiment, aged rats were divided into a sham group and abdominal surgery group. In insulin experiment, sham and surgically treated rats were distributed into two groups: an intranasal denatured insulin-treated group and intranasal insulin-treated group. Insulin administration started the day of surgery and continued for 3days. Fourteen-days after surgery, cognitive function was assessed using a novel object recognition test, followed by measurement of hippocampal levels of pro-inflammatory cytokines, GSK-3β, and phosphorylated GSK-3β (pGSK-3β(ser9)). Under identical conditions, lipopolysaccharide (LPS)-induced cytokine release from isolated hippocampal microglia was also tested. In non-insulin experiment, compared with non-surgical animals, the rats that underwent abdominal surgery showed memory deficits and increased hippocampal cytokine levels. The hippocampal ratio of pGSK-3β(ser9)/GSK-3β decreased after surgery, a ratio that was positively correlated with novel object recognition performance in the testing phase. Insulin experiment revealed that perioperative intranasal insulin administration could restore the surgery-induced hippocampal neuroinflammation and hyperactivation of GSK-3β, and prevent impairment in novel object recognition. Furthermore, ex vivo experiments indicated that intranasal insulin administration, as well as pretreatment with SB216763, a GSK-3β inhibitor, resulted in reduction of the surgery-related microglial hyper-reactivity to LPS. Our findings in aged rats suggest that surgical procedures could impair central insulin signaling including GSK-3β, which makes the individual more susceptible to hippocampal neuroinflammation and related cognitive disorders. (キーワード) Animals / Cognition Disorders / Glycogen Synthase Kinase 3 / Hippocampus / Insulin / Male / Postoperative Period / Rats / Rats, Wistar / Signal Transduction (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.lfs.2016.08.020 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27561842 ● Search Scopus @ Elsevier (PMID): 27561842 ● Search Scopus @ Elsevier (DOI): 10.1016/j.lfs.2016.08.020 (DOI: 10.1016/j.lfs.2016.08.020, PubMed: 27561842)
19.	Takashi Kawano, Satoru Eguchi, H Iwata, D Yamanaka, H Tateiwa, FM Locatelli and M Yokoyama : Pregabalin can prevent, but not treat, cognitive dysfunction following abdominal surgery in aged rats., Life Sciences, Vol.148, 211-219, 2016. (要約) The present study aimed to explore the preventive or therapeutic effect of peri-operative pregabalin treatment on the memory deficits and related hippocampal inflammation following surgery in aged rats. Aged rats underwent abdominal or sham surgery, and were then divided into 2 groups, either early or late pregabalin treatment. Fourteen days after surgery, the cognitive function was assessed using novel object recognition test, followed by measurement of hippocampal cytokines and voltage-dependent calcium channel α2δ subunit (CACNA2D1). The parabiotic experiments determined whether the humoral or neuronal pathway was involved in the neuroinflammation development following the abdominal surgery. The effects of pregabalin on LPS-induced cytokine release from hippocampal microglia were also evaluated. Early pregabalin treatment, which was administered pre-operatively and continued for 3 or 7days after surgery, prevented memory deficits and decreased hippocampal pro-inflammatory cytokine levels. In contrast, no beneficial effects were observed when pregabalin was administered late in the post-operative period. The hippocampal levels of CACNA2D1 did not change under any experimental condition. The data from the cross-circulation (parabiosis) experiments indicated that abdominal surgery may induce neuroinflammation via a neural transmission pathway from the periphery to the brain. The ex vivo experiments further demonstrated that pregabalin had no effect on LPS-induced cytokines release from hippocampal microglia. Our findings highlight reveal that peri-operative pregabalin treatment during the early post-operative period can prevent neuroinflammation and memory deficits after surgery. It is likely this occurs through a peripheral and central neuro-immune interaction rather than through direct anti-inflammatory effects. (キーワード) Abdominal Muscles / Aging / Animals / Cognition Disorders / Male / Postoperative Complications / Pregabalin / Preoperative Care / Rats / Rats, Wistar / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.lfs.2016.02.021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26872983 ● Search Scopus @ Elsevier (PMID): 26872983 ● Search Scopus @ Elsevier (DOI): 10.1016/j.lfs.2016.02.021 (DOI: 10.1016/j.lfs.2016.02.021, PubMed: 26872983)
20.	Takashi Kawano, Satoru Eguchi, Hideki Iwata, Daiki Yamanaka, Hiroki Tateiwa, Locatelli M Fabricio and Masataka Yokoyama : Effects and underlying mechanisms of endotoxemia on post-incisional pain in rats, Life Sciences, Vol.148, 145-153, 2016. (要約) The aim of the present study was to investigate the effects and underlying mechanisms of endotoxin (lipopolysaccharide, LPS) on postoperative pain using a rat model of incisional pain. Animals were assigned to one of four groups using a 2×2 experimental design: a single intraperitoneal injection of 5mg/kg LPS versus vehicle, by plantar incision versus anesthesia alone. Spontaneous pain and mechanical paw withdrawal threshold (PWT) were evaluated using Rat Grimace Scale (RGS) and von Frey fibers, respectively. Analgesic effects of ketoprofen, morphine, and wound infiltration with ropivacaine, as well as the contribution of the Toll-like receptor (TLR) 4 pathway, were also evaluated. In vivo single fiber recordings were performed to assess the nociceptive afferent signals from the surgical site. Systemic administration of LPS significantly increased the pain intensity at 2h after hind paw incision, but did not affect the PWT. The duration of post-incisional pain assessed by both scales did not significantly differ in the presence or absence of LPS. The analgesic efficiency of ketoprofen and morphine was reduced by LPS, while that of wound infiltration with ropivacaine was preserved. On the other hand, in vivo single fiber recording failed to demonstrate any significant effects of LPS on the activity of primary afferents due to mechanical stimuli. Pre-treatment with intrathecal LPS from Rhodobacter sphaeroides, a TLR-4 antagonist, almost completely inhibited LPS-induced exacerbated post-incisional pain, and decreased analgesic responsiveness. The present results suggested that LPS exacerbates post-incisional pain via the central TLR-4 pathway. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.lfs.2016.01.046 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26835988 ● Summary page in Scopus @ Elsevier: 2-s2.0-84958980680 (DOI: 10.1016/j.lfs.2016.01.046, PubMed: 26835988, Elsevier: Scopus)
21.	Takashi Kawano, Tetsuya Takahashi, Satomi Kaminaga, Takao Kadono, Daiki Yamanaka, Hideki Iwata, Satoru Eguchi and Masataka Yokoyama : A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats., Journal of Anesthesia, Vol.29, No.4, 631-634, 2015. (要約) Serotonin syndrome is a drug-related toxicity caused by excess serotonin within the central nervous system. We recently encountered a case of serotonin syndrome that developed in the early postoperative period that was successfully treated with intravenous dexmedetomidine. Although the prescriptive literature has commonly recommended sedation with benzodiazepines for controlling agitation in serotonin syndrome, the effectiveness of dexmedetomidine has also been reported in several clinical conditions. In the present study, we conducted a reverse translational experiment to compare the efficacy of dexmedetomidine and midazolam, at equi-sedative doses, on serotonergic toxicity-like responses in rats. Animals were subcutaneously injected with 0.75 mg/kg 8-OH-DPAT, a full 5-HT1A agonist. 8-OH-DPAT-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with WAY 100635, a selective 5-HT1A antagonist (n = 8). Intramuscular injection of midazolam (1.0 mg/kg) or dexmedetomidine (0.01 mg/kg), which comparably induced observable signs of sedation, was tested in the present study. Concomitant treatment with midazolam significantly attenuated the hyperlocomotion, but failed to affect traditional serotonin syndrome behaviors and body temperature in 8-OH-DPAT-treated rats (n = 8). On the other hand, concomitant treatment with dexmedetomidine significantly attenuated all of these parameters (n = 8). The present case and related reverse translational experiment demonstrate that dexmedetomidine may be more beneficial for the treatment of serotonin syndrome compared to the current recommended treatment with benzodiazepines. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-014-1973-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25596946 ● Summary page in Scopus @ Elsevier: 2-s2.0-84939564177 (DOI: 10.1007/s00540-014-1973-9, PubMed: 25596946, Elsevier: Scopus)
22.	Takashi Kawano, Satoru Eguchi, Hideki Iwata, Takahiko Tamura, Naoko Kumagai and Masataka Yokoyama : Impact of Preoperative Environmental Enrichment on Prevention of Development of Cognitive Impairment following Abdominal Surgery in a Rat Model., Anesthesiology, Vol.123, No.1, 160-170, 2015. (要約) Sustained neuroinflammation may contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Here, the authors evaluated the preventive effect of preoperative environmental enrichment (PEE) on the development of neuroinflammation and concomitant POCD in a rat abdominal surgery model. Young and aged rats were assigned to one of four groups using a 2 × 2 experimental design: PEE versus sedentary condition for 14 days, by abdominal surgery versus anesthesia alone (n = 8 in each group). After a 7-day postsurgical recovery period, cognitive function was assessed using a novel object recognition test, followed by measurement of hippocampal levels of proinflammatory cytokines. Under identical conditions, microglia were isolated from the hippocampus for assessment of cytokine response to lipopolysaccharide. In the sedentary group, aged, but not young, rats receiving surgery showed memory deficits (novel object preference during testing phase of 54.6 ± 7.8% vs. 76.9 ± 11.3% in nonsurgery group, P < 0.05) and increased hippocampal levels of cytokines compared with nonsurgical rats. PEE had no effects on novel object preference in nonsurgery animals (78.6 ± 10.7%), whereas it attenuated surgery-induced impairment of novel object preference (70.9 ± 15.0%, P < 0.05 vs. sedentary/surgery group) as well as increase of cytokine levels in hippocampus. Furthermore, upon ex vivo stimulation with lipopolysaccharide, cytokines release from hippocampal microglia isolated from aged rats before intervention was significantly higher in comparison with young rats. PEE resulted in reduction of these age-related microglial phenotypic changes. PEE could prevent the development of neuroinflammation and related POCD in aged rats by reversion of a proinflammatory phenotype of hippocampal microglia. (キーワード) Abdomen / Animals / Cognition Disorders / Disease Models, Animal / Laparotomy / Male / Microglia / Postoperative Complications / Preoperative Care / Rats / Rats, Wistar / Social Environment (出版サイトへのリンク) ● Publication site (DOI): 10.1097/ALN.0000000000000697 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26001032 ● Summary page in Scopus @ Elsevier: 2-s2.0-84937407615 (DOI: 10.1097/ALN.0000000000000697, PubMed: 26001032, Elsevier: Scopus)
23.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 北畑洋 : 特発性間質性肺炎を合併した患者に対する口腔外科長時間手術の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.43, No.2, 265-267, 2015年.
24.	大塚良, 青山智祐, 江口覚, 高石和美, 富岡重正, 北畑洋 : 静脈穿刺により発症した血管迷走神経性失神時に心拍変動解析を行った1例, 日本歯科麻酔学会雑誌, Vol.43, No.2, 268-270, 2015年.
25.	Takashi Kawano, Takahashi Tetsuya, Iwata Hideki, Morikawa Akihiro, Imori Satoko, Waki Sayaka, Tamura Takahiko, Yamazaki Fumimoto, Satoru Eguchi, Kumagai Naoko and Yokoyama Masataka : Effects of ketoprofen for prevention of postoperative cognitive dysfunction in aged rats, Journal of Anesthesia, Vol.28, No.6, 932-936, 2014. (要約) Postoperative cognitive dysfunction is a common geriatric complication that may be associated with increased mortality. Here, we investigated the effects of postoperative analgesia with ketoprofen on cognitive functions in aged animals and compared its effectiveness to morphine. Rats were randomly allocated to one of four groups: isoflurane anesthesia without surgery (group C), isoflurane anesthesia with laparotomy (group IL), and isoflurane anesthesia with laparotomy plus postoperative analgesia with ketoprofen or morphine. There was no difference in postoperative locomotor activity among groups. In group IL, postoperative pain levels assessed by the Rat Grimace Scale significantly increased until 8 h after surgery, which was similarly inhibited by both ketoprofen and morphine. Cognitive function was assessed using radial arm maze testing for 12 consecutive days from postoperative day 3. Results showed that the number of memory errors in group IL were significantly higher than those in goup C. However, both ketoprofen and morphine could attenuate the increase in memory errors following surgery to a similar degree. Conversely, ketoprofen showed no effect on cognitive function in the nonsurgical rats that did not experience pain. Our findings suggest that postoperative analgesia with ketoprofen can prevent the development of surgery-associated memory deficits via its pain-relieving effects. (キーワード) Anesthesia / Animals / Cognition / Isoflurane / Ketoprofen / Male / Memory / Morphine / Pain Measurement / Pain, Postoperative / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-014-1821-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24676769 ● Summary page in Scopus @ Elsevier: 2-s2.0-84905028653 (DOI: 10.1007/s00540-014-1821-y, PubMed: 24676769, Elsevier: Scopus)
26.	Takahashi Tetsuya, Kawano Takashi, Satoru Eguchi, Chi Haidong, Iwata Hideki and Yokoyama Masataka : Effects of dexmedetomidine on insulin secretion from rat pancreatic β cells, Journal of Anesthesia, Vol.29, No.3, 396-402, 2014. (要約) Dexmedetomidine acts as a selective α2-adrenergic receptor agonist and an imidazoline receptor agonist, both of which are known to affect insulin secretion. Here, we investigated the effects of clinically relevant concentrations of dexmedetomidine on insulin secretion under in vivo conditions. Furthermore, its underlying mechanisms were examined using isolated islets in vitro. For the in vivo oral glucose tolerance test (OGTT), male Sprague-Dawley rats were randomly allocated to one of three groups (n = 7 in each group): two groups infused with dexmedetomidine at a low (group L) or a high (group H) dose, and one control group infused with the same amount of saline (group C). For the in vitro perifusion study, insulin released from isolated islets was measured during stepwise changes in glucose. Dexmedetomidine (0.1-100 µM) was added to the chamber. During the OGTT test, the insulin levels in group H were significantly lower than those in group C at 30, 60, and 90 min after glucose load. On the other hand, insulin levels in group L were comparable to those of group C at all time points. In the perfusion study, dexmedetomidine inhibited glucose-stimulated insulin secretion in a concentration-dependent manner. When co-treated with yohimbine, an α2-adrenoceptor blocker, dexmedetomidine adversely increased glucose-induced insulin secretion. However, co-treatment with idazoxan, an antagonist for α2-adrenergic and imidazoline receptors, completely abolished the action of dexmedetomidine. Dexmedetomidine had no effect on insulin secretion at sedative dose, whereas it significantly inhibited insulin secretion at supraclinical high concentrations mainly via the α2-adrenoceptor. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-014-1943-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25376970 ● Summary page in Scopus @ Elsevier: 2-s2.0-84934443085 (DOI: 10.1007/s00540-014-1943-2, PubMed: 25376970, Elsevier: Scopus)
27.	Kazumi Takaishi, Shinji Kawahito, Shigemasa Tomioka, Satoru Eguchi and Hiroshi Kitahata : Cuffed oropharyngeal airway for difficult airway management., Anesthesia Progress, Vol.61, No.3, 107-110, 2014. (要約) Abstract Difficulties with airway management are often caused by anatomic abnormalities due to previous oral surgery. We performed general anesthesia for a patient who had undergone several operations such as hemisection of the mandible and reconstructive surgery with a deltopectoralis flap, resulting in severe maxillofacial deformation. This made it impossible to ventilate with a face mask and to intubate in the normal way. An attempt at oral awake intubation using fiberoptic bronchoscopy was unsuccessful because of severe anatomical abnormality of the neck. We therefore decided to perform retrograde intubation and selected the cuffed oropharyngeal airway (COPA) for airway management. We inserted the COPA, not through the patient's mouth but through the abnormal oropharyngeal space. Retrograde nasal intubation was accomplished with controlled ventilation through the COPA, which proved to be very useful for this difficult airway management during tracheal intubation even though the method was unusual. (出版サイトへのリンク) ● Publication site (DOI): 10.2344/0003-3006-61.3.107 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25191984 ● Search Scopus @ Elsevier (PMID): 25191984 ● Search Scopus @ Elsevier (DOI): 10.2344/0003-3006-61.3.107 (DOI: 10.2344/0003-3006-61.3.107, PubMed: 25191984)
28.	H Chi, Takashi Kawano, T Tamura, H Iwata, Y Takahashi, Satoru Eguchi, F Yamazaki and M Yokoyama : Postoperative pain impairs subsequent performance on a spatial memory task via effects on N-methyl-D-aspartate receptor in aged rats., Life Sciences, Vol.93, No.25-26, 986-993, 2013. (要約) Pain may be associated with postoperative cognitive dysfunction (POCD); however, this relationship remains under investigated. Therefore, we examined the impact of postoperative pain on cognitive functions in aged animals. Rats were allocated to the following groups: control (C), 1.2 % isoflurane for 2 hours alone (I), I with laparotomy (IL), IL with analgesia using local ropivacaine (IL+R), and IL with analgesia using systemic morphine (IL+M). Pain was assessed by rat grimace scale (RGS). Spatial memory was evaluated using a radial maze from postoperative days (POD) 3 to 14. NMDA receptor (NR) 2 subunits in hippocampus were measured by ELISA. Finally, effects of memantine, a low-affinity uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, on postoperative cognitive performance were tested. Postoperative RGS was increased in Group IL, but not in other groups. The number of memory errors in Group I were comparable to that in Group C, whereas errors in Group IL were increased. Importantly, in Group IL+R and IL+M, cognitive impairment was not found. The memory errors were positively correlated with the levels of NMDA receptor 2 subunits in hippocampus. Prophylactic treatment with memantine could prevent the development of memory deficits observed in Group IL without an analgesic effect. Postoperative pain contributes to the development of memory deficits after anesthesia and surgery via up-regulation of hippocampal NMDA receptors. Our findings suggest that postoperative pain management may be important for the prevention of POCD in elderly patients. (キーワード) Age Factors / Amides / Anesthetics / Animals / Hippocampus / Isoflurane / Male / Maze Learning / Memantine / Memory / Morphine / Pain, Postoperative / Protein Subunits / Rats / Rats, Wistar / Receptors, N-Methyl-D-Aspartate (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.lfs.2013.10.028 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24211778 ● Summary page in Scopus @ Elsevier: 2-s2.0-84889083248 (DOI: 10.1016/j.lfs.2013.10.028, PubMed: 24211778, Elsevier: Scopus)
29.	Fumimoto Yamazaki, H Chi, Satoru Eguchi and Takashi Kawano : Activation of ATP-sensitive potassium channels by nicorandil is preserved in aged vascular smooth muscle cells in rats., Journal of Anesthesia, Vol.27, No.4, 623-626, 2013. (要約) Nicorandil, an ATP-sensitive potassium (KATP) channel opener having the properties of a nitrate, causes vasodilation, particularly of coronary arteries, and has been reported to reduce the frequency of perioperative cardiac events. We previously demonstrated that isoflurane could activate vascular KATP channels through an intracellular signaling pathway, but that this isoflurane-induced channel opening is suppressed by aging. Here, we investigated whether advanced age modifies nicorandil-induced activation of vascular KATP channels. We used a cell-attached patch-clamp configuration to test the effects of nicorandil on KATP channel activity in vascular smooth muscle cells (VSMCs) obtained from 12- to 15-week-old (adult) and 24- to 25-month-old (aged) male Wistar rats. Bath application of nicorandil (0.1-100 μM) activated KATP channels to a level similar to that observed in VSMCs from the arteries of both adult and aged rats. Furthermore, concomitant bath application of nicorandil in the aged group dose-dependently ameliorated the age-related reduction in isoflurane-induced vascular KATP channel activation. Our findings indicate that nicorandil could be used effectively in elderly patients to directly activate vascular KATP channels during the perioperative period. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-013-1582-z (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23460408 ● Search Scopus @ Elsevier (PMID): 23460408 ● Search Scopus @ Elsevier (DOI): 10.1007/s00540-013-1582-z (DOI: 10.1007/s00540-013-1582-z, PubMed: 23460408)
30.	立石智子, 富岡重正, 古北まゆ子, 高瀬奈緒, 大西杏奈, 高石和美, 江口覚, 北畑洋 : 尋常性天疱瘡患者における頬粘膜腫瘍切除術の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.40, No.5, 610-611, 2012年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571417126119421056 ● Summary page in Scopus @ Elsevier: 2-s2.0-84868528160 (CiNii: 1571417126119421056, Elsevier: Scopus)
31.	Takashi Kawano, Katsuya Tanaka, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki, Sonoe Kitamura, Naoko Kumagai and Masataka Yokoyama : Biophysical and Pharmacological Properties of Glucagon-Like Peptide-1 in Rats Under Isoflurane Anesthesia., Anesthesia & Analgesia, Vol.115, No.1, 62-69, 2012. (要約) Glucagon-like peptide-1 (GLP-1) increases insulin secretion and has an important role in maintaining glucose homeostasis. In this study, we evaluated the biophysical and pharmacological properties of GLP-1 by performing in vivo and in vitro experiments to determine the applicability of GLP-1 in glycemic control in rats under isoflurane anesthesia. Levels of portal GLP-1, insulin, and glucose and dipeptidyl peptidase-4 activity were measured in the basal fasting state and after gastric glucose load before, during, and after exposure to 30% O(2) in air (control) or 1.4% isoflurane in a mixture of 30% O(2) and air. The direct effects of isoflurane on GLP-1 secretion were assessed in human enteroendocrine NCI-H716 cells. Insulin release from isolated pancreatic islets was measured using a radioimmunoassay. Single pancreatic β-cell membrane potentials were recorded using whole-cell current-clamp patches perforated by β-escin. In fasting rats, inhalation of isoflurane led to a decrease in the basal levels of GLP-1 but did not affect insulin and glucose levels. Levels of GLP-1, insulin, and glucose increased after gastric administration of glucose in control rats. However, isoflurane attenuated the glucose-induced increase in GLP-1 and insulin levels and increased plasma glucose levels. In contrast, isoflurane did not affect dipeptidyl peptidase-4 activity before or after gastric glucose loading. Isoflurane (0.35 mM) inhibited GLP-1 release in NCI-H716 cells; this finding was similar to that observed in in vivo studies. In perifusion experiments, isoflurane (0.35 mM) inhibited glucose-induced insulin release, whereas exogenous GLP-1 (10 nM) enhanced insulin release. Importantly, combined administration of isoflurane and GLP-1 enhanced both phases of glucose-induced insulin release to an extent similar to that achieved with GLP-1 alone. Whole-cell patches showed that exposure to GLP-1 (10 nM) led to nearly complete restoration of glucose-stimulated depolarization that had been suppressed by isoflurane (0.35 mM). GLP-1 secretion is impaired during isoflurane anesthesia. However, our study showed that the insulinotropic action of GLP-1 was not affected by isoflurane. Furthermore, exposure to GLP-1 increased the membrane activity of pancreatic β-cells, preventing isoflurane-induced impairment of glucose-induced insulin secretion. These results support the hypothesis that GLP-1-based therapy may be a useful approach for achieving intraoperative glycemic control. (キーワード) Anesthetics, Inhalation / Animals / Biological Markers / Blood Glucose / Cell Line / Dipeptidyl Peptidase 4 / Enteroendocrine Cells / Glucagon-Like Peptide 1 / 生体恒常性 (homeostasis) / Humans / インスリン (insulin) / Islets of Langerhans / Isoflurane / Male / Membrane Potentials / Patch-Clamp Techniques / Perfusion / Radioimmunoassay / Rats / Rats, Sprague-Dawley / Stomach / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1213/ANE.0b013e318253cbf0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22504208 ● Search Scopus @ Elsevier (PMID): 22504208 ● Search Scopus @ Elsevier (DOI): 10.1213/ANE.0b013e318253cbf0 (DOI: 10.1213/ANE.0b013e318253cbf0, PubMed: 22504208)
32.	Takashi Kawano, Fumimoto Yamazaki, Shinji Kawahito and Satoru Eguchi : Dexmedetomidine directly inhibits vascular ATP-sensitive potassium channels., Life Sciences, Vol.90, No.7-8, 272-277, 2012. (要約) Dexmedetomidine is reported to have an effect on peripheral vasoconstriction; however, the exact mechanisms underlying this process are unclear. In this study, we hypothesized that dexmedetomidine-induced inhibition of vascular ATP-sensitive K(+) (K(ATP)) channels may be associated with this vasoconstriction. To test this hypothesis, we investigated the effects of dexmedetomidine on vascular K(ATP)-channel activity at the single-channel level. We used cell-attached and inside-out patch-clamp configurations to examine the effects of dexmedetomidine on the activities of native rat vascular K(ATP) channels, recombinant K(ATP) channels with different combinations of various inwardly rectifying potassium channels (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor subunits (SUR1, 2A, 2B), and SUR-deficient channels derived from a truncated isoform of Kir6.2 subunit, namely, Kir6.2ΔC36 channels. Dexmedetomidine was observed to inhibit the native rat vascular K(ATP) channels in both cell-attached and inside-out configurations. This drug also inhibited the activity of all types of recombinant SUR/Kir6.0 K(ATP) channels as well as Kir6.2ΔC36 channels with equivalent potency. These results indicate that dexmedetomidine directly inhibits K(ATP) channels through the Kir6.0 subunit. (キーワード) Adrenergic alpha-2 Receptor Agonists / Animals / Aorta / Dexmedetomidine / KATP Channels / Male / Rats / Rats, Wistar / Recombinant Proteins (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.lfs.2011.11.009 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22155038 ● Search Scopus @ Elsevier (PMID): 22155038 ● Search Scopus @ Elsevier (DOI): 10.1016/j.lfs.2011.11.009 (DOI: 10.1016/j.lfs.2011.11.009, PubMed: 22155038)
33.	Takashi Kawano, Tomohiro Soga, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki and Masataka Yokoyama : The involvement of the neurosteroid allopregnanolone in the antihyperalgesic effect of paroxetine in a rat model of neuropathic pain, NeuroReport, Vol.22, No.18, 984-988, 2011. (要約) Paroxetine increases the levels of neurosteroids, such as allopregnanolone (AP), that influence the excitability of the central nervous system by positive allosteric modulation of γ-aminobutyric acid type A receptors. Here, we investigated the role of AP synthesis on the paroxetine-induced antihyperalgesic effect in a rat model of neuropathic pain induced by lumbar spinal nerve ligation (SNL). Subcutaneous administration of paroxetine in SNL rats, dose-dependently decreased the probability of hyperalgesic response and increased AP levels in the spine but not in either brain or serum. Concomitant treatment with an inhibitor of the AP-synthesizing enzyme, finasteride, attenuated the paroxetine-induced antihyperalgesic effect as well as the paroxetine-induced increase in spinal AP levels. Intrathecal injection of exogenous AP mimicked the analgesic effects of paroxetine in vehicle-treated SNL rats, whereas no additional analgesic effects were observed in paroxetine-treated SNL rats. Our findings suggest that the antihyperalgesic effect of paroxetine in a rat neuropathic pain model is AP-mediated. These results also suggest that pharmacological-based therapies targeting AP synthesis might be a promising treatment for neuropathic pain. (キーワード) Animals / Brain / Central Nervous System Stimulants / Disease Models, Animal / Hyperalgesia / Ligation / Male / Neuralgia / Pain Threshold / Paroxetine / Pregnanolone / Radioimmunoassay / Rats / Rats, Sprague-Dawley / Spinal Cord (出版サイトへのリンク) ● Publication site (DOI): 10.1097/WNR.0b013e32834da80d (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22045256 ● Search Scopus @ Elsevier (PMID): 22045256 ● Search Scopus @ Elsevier (DOI): 10.1097/WNR.0b013e32834da80d (DOI: 10.1097/WNR.0b013e32834da80d, PubMed: 22045256)
34.	Takashi Kawano, Tomohiro Soga, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki and Masataka Yokoyama : Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats, Journal of Anesthesia, Vol.25, No.6, 942-945, 2011. (要約) The neurosteroid allopregnanolone (AP) influences the excitability of the central nervous system by acting as a positive allosteric modulator of γ-aminobutyric acid type A (GABA(A)) receptors. Here, we investigated the role of AP and its therapeutic potential in rats that showed hyperalgesic behavior after undergoing spinal nerve ligation (SNL). AP levels measured in the spinal cord and brain of rats that underwent SNL were greater than the corresponding levels in control animals. More importantly, spinal AP levels in hyperalgesic rats were lower than those in the rats that did not develop hyperalgesia following SNL; in contrast, brain AP levels were comparable among these groups. No differences in serum AP levels were observed among the groups. In addition, intrathecal exogenous administration of AP showed the antihyperalgesic effects in hyperalgesic rats after SNL. These findings suggest that changes in spinal AP biosynthesis are involved in the pathogenesis of neuropathic pain following peripheral nerve injury, and pharmacological manipulation of this phenomenon may provide a potential therapeutic target for neuropathic pain. (キーワード) Anesthetics / Animals / 脳 (brain) / Hyperalgesia / Neuralgia / Neurotransmitter Agents / Pain / Peripheral Nerve Injuries / Pregnanolone / Rats / 脊髄 (spinal cord) / Spinal Nerves (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00540-011-1216-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21879341 ● CiNii @ 国立情報学研究所 (CRID): 1573950400521060864 ● Summary page in Scopus @ Elsevier: 2-s2.0-84355161737 (DOI: 10.1007/s00540-011-1216-2, PubMed: 21879341, CiNii: 1573950400521060864, Elsevier: Scopus)
35.	Takashi Kawano, Katsuya Tanaka, Haidong Chi, Masakazu Kimura, Hiroaki Kawano, Satoru Eguchi and Shuzo Oshita : Effects of aging on isoflurane-induced and protein kinase A-mediated activation of ATP-sensitive potassium channels in cultured rat aortic vascular smooth muscle cells., Journal of Cardiovascular Pharmacology, Vol.56, No.6, 676-685, 2010. (要約) Isoflurane activates protein kinase A (PKA) in vascular smooth muscle cells (VSMCs), which in turn activates ATP-sensitive potassium (K(ATP)) channels and causes vasodilation. The present study was undertaken to examine whether advanced age influences the effect of isoflurane on K(ATP) channel activity in cultured VSMCs. We used VSMCs obtained from 12- to 15-week-old (adult) and 24- to 25-month-old (aged) male Wistar rats. Electrophysiological experiments were performed using cell-attached and inside-out patch-clamp techniques to monitor the K(ATP) channel activity. Application of isoflurane or forskolin to the bath solution in cell-attached recordings induced a significant increase in K(ATP) channel activity in the VSMCs from the adult group. However, K(ATP) channel opening induced by isoflurane, but not forskolin, was significantly suppressed by aging. On the other hand, cell-free recordings showed similar pharmacologic sensitivity to the K(ATP) channel opener pinacidil, inward rectification, and unitary conductance (40 45 pS) between groups. In addition, direct K(ATP) channel activation by c-PKA in the inside-out patches was similar in both groups. Furthermore, increasing PKA activation in cell-attached patches by CPT-cAMP restored isoflurane's effects in the aged group. These results suggest that aging decreases isoflurane-induced PKA activation, resulting in attenuation of K(ATP) channel opening. (キーワード) Aging / Animals / Aorta / Cells, Cultured / Cyclic AMP-Dependent Protein Kinases / Isoflurane / KATP Channels / Male / Muscle, Smooth, Vascular / Myocytes, Smooth Muscle / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1097/FJC.0b013e3181fc4671 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20881605 ● Search Scopus @ Elsevier (PMID): 20881605 ● Search Scopus @ Elsevier (DOI): 10.1097/FJC.0b013e3181fc4671 (DOI: 10.1097/FJC.0b013e3181fc4671, PubMed: 20881605)
36.	Takashi Kawano, Katsuya Tanaka, hua Yin, Satoru Eguchi, Hiroaki Kawano, Akira Takahashi, Yutaka Nakaya and Shuzo Oshita : Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle., The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 237-244, 2010. (要約) Nicorandil opens adenosine triphosphate-sensitive potassium (K(ATP)) channels in the cardiovascular system and is being increasingly used for the treatment of angina pectoris. In the present study, we tested whether intravenous anesthetic agent ketamine affected nicorandil-induced native vascular K(ATP) channel activation. (キーワード) Adenosine Diphosphate / Anesthetics, Dissociative / Animals / Cell Line / Dose-Response Relationship, Drug / Electrophysiological Phenomena / Glyburide / KATP Channels / Ketamine / Myocytes, Smooth Muscle / Nicorandil / Patch-Clamp Techniques / Rats / Stereoisomerism (徳島大学機関リポジトリ) ● Metadata: 79136 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.57.237 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847523 ● CiNii @ 国立情報学研究所 (CRID): 1390001204244070144 ● Search Scopus @ Elsevier (PMID): 20847523 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.237 (徳島大学機関リポジトリ: 79136, DOI: 10.2152/jmi.57.237, PubMed: 20847523, CiNii: 1390001204244070144)
37.	高石和美, 富岡重正, 江口覚, 中井恵, 岩田英道, 榎本奈実, 髙丸菜都美, 北畑洋 : 小児患者の精神鎮静法に関する過去10年間の検討, 日本歯科麻酔学会雑誌, Vol.38, No.2, 176-179, 2010年. (キーワード) SEDATION / 子ども (children) / INTRAVENOUS / INHALATION / PREMEDICATION (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571980075955865728 (CiNii: 1571980075955865728)
38.	Takashi Kawano, Tomohito Kawano, Katsuya Tanaka, Satoru Eguchi, Akira Takahashi, Yutaka Nakaya and Shuzo Oshita : Effects of dopamine on ATP-sensitive potassium channels in porcine coronary artery smooth-muscle cells, Journal of Cardiovascular Pharmacology, Vol.51, No.2, 196-201, 2008. (要約) Dopamine is reported to be a coronary vasodilator; however, the exact mechanism of dopamine action in the coronary circulation remains unclear. In this study, we hypothesized that dopamine-induced activation of coronary ATP-sensitive potassium (KATP) channels may be associated with coronary vasodilation. We therefore investigated the direct effects of dopamine on coronary KATP-channel activity. We used patch-clamp configurations to investigate the effects of dopamine on coronary KATP-channel activity. Application of dopamine (10 to 10 M) to the bath solution during cell-attached recordings induced a concentration-dependent increase in KATP-channel activity. In contrast, dopamine failed to activate KATP channels in inside-out patches. Dopamine-induced coronary KATP-channel currents in cell-attached patches were inhibited by pretreatment with the selective D1-like antagonist, Sch-23390, but they were not influenced by the selective D2-like antagonist, domperidone, or the beta-adrenergic receptor antagonist, propranolol. The selective D1-like agonist, SKF-38393, and the adenylyl cyclase activator, forskolin, mimicked the dopamine effects on coronary KATP channels. Furthermore, pretreatment with an inhibitor of protein kinase A, Rp-cAMPS, abolished the dopamine-induced KATP-channel activation. This study demonstrates that dopamine activates coronary KATP channels via signal transduction involving the D1-like dopaminergic receptor-protein kinase A-signaling pathway. (キーワード) 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Animals / Benzazepines / Cardiotonic Agents / Cells, Cultured / Coronary Vessels / Cyclic AMP / Cyclic AMP-Dependent Protein Kinases / Domperidone / Dopamine / Dopamine Agonists / Dopamine Antagonists / Forskolin / KATP Channels / Myocytes, Smooth Muscle / Patch-Clamp Techniques / Propranolol / Receptors, Dopamine D1 / Signal Transduction / Swine / Thionucleotides / Vasodilator Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1097/FJC.0b013e31815f2be7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18287888 ● Search Scopus @ Elsevier (PMID): 18287888 ● Search Scopus @ Elsevier (DOI): 10.1097/FJC.0b013e31815f2be7 (DOI: 10.1097/FJC.0b013e31815f2be7, PubMed: 18287888)
39.	Satoru Eguchi, Takashi Kawano, hua Yin, Katsuya Tanaka, Sonoko Yasui, Kazuaki Mawatari, Akira Takahashi, Yutaka Nakaya, Shuzo Oshita and Nobuyoshi Nakajo : Effects of prostaglandin E1 on vascular ATP-sensitive potassium channels., Journal of Cardiovascular Pharmacology, Vol.50, No.6, 686-691, 2007. (要約) BACKGROUND: Prostaglandin E1 (PGE1) has been reported to activate ATP-sensitive potassium (KATP) channels, which induces vasorelaxation. However, direct evidence of PGE1 interactions with vascular KATP channels is limited. METHODS: The present study investigated the effects and mechanisms of PGE1 on vascular KATP channels in both isometric tension and patch clamp experiments.Isometric tension experiments were performed in rat thoracic aortic rings without an endothelium. Electrophysiologic experiments were performed using patch-clamp techniques to monitor KATP channels in rat vascular smooth muscle cells. RESULTS: PGE1 significantly decreased the isometric tension in a concentration-dependent manner, which was partially inhibited by pretreating with a KATP channel inhibitor, glibenclamide (1 microM), or an inhibitor of protein kinase A (PKA), Rp-cAMPS (100 microM). Application of PGE1 to the bath solution during cell-attached recordings induced a significant increase in KATP channel activity, whereas PGE1 failed to activate KATP channels in the inside-out patches. The PGE1-induced KATP channel currents in cell-attached patches were abolished by pretreating with Rp-cAMPS (100 microM). CONCLUSIONS: The results indicate that the activation of vascular KATP channels played an important role in the PKA-dependent PGE1-induced vasorelaxation. Furthermore, an electrophysiological experiment demonstrated that PGE1 activated vascular KATP channels via PKA activation. (キーワード) Algorithms / Alprostadil / Analysis of Variance / Animals / Aorta, Thoracic / Cyclic AMP / Cyclic AMP-Dependent Protein Kinases / Dose-Response Relationship, Drug / Forskolin / Glyburide / KATP Channels / Male / Patch-Clamp Techniques / Phenylephrine / Pinacidil / Protein Kinase Inhibitors / Rats / Rats, Wistar / Thionucleotides / Vasoconstriction / Vasodilation / Vasodilator Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1097/FJC.0b013e3181583d9b (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18091586 ● Search Scopus @ Elsevier (PMID): 18091586 ● Search Scopus @ Elsevier (DOI): 10.1097/FJC.0b013e3181583d9b (DOI: 10.1097/FJC.0b013e3181583d9b, PubMed: 18091586)
40.	大下修弘, 高石和美, 江口覚, 張剛太, 富岡重正, 中條信義 : 全身麻酔時に不整脈を呈した高校生スポーツ選手の麻酔経験, 麻酔, Vol.54, No.6, 676-679, 2005年. (要約) A 17-year-old man with fracture of the mandible underwent open fixation under general anesthesia. He was an athlete of the rugby suffering the fracture in a match. His preoperative physical examinations were normal except for I degrees atrioventricular block on electrocardiogram (ECG). During anesthesia, atrioventricular dissociation and frequent premature ventricular contractions were induced by the stimulation of nasotracheal intubation and the administration of atropine for the reversal of muscle relaxation. We thought the cause of the arrhythmia is the athlete's heart which may be vagotonic and may induce vagal reflex or fatal arrhythmia. This case demonstrates that it is necessary to pay attention to chronotropic action associated with the intubation of nasopharynx, the handling of laryngoscope and the usage of drugs for the anesthetic management of the athlete. (キーワード) スポーツ心臓 / 房室解離 / 変時作用 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15966390 ● CiNii @ 国立情報学研究所 (CRID): 1520572359236520704 ● Summary page in Scopus @ Elsevier: 2-s2.0-21044448574 (PubMed: 15966390, CiNii: 1520572359236520704, Elsevier: Scopus)
41.	江口覚, 河野崇, 大下修造, 中條信義 : ニコランジルによる培養ラット血管平滑筋細胞のATP感受性Kチャネル活性に及ぼすプロポフォールとチアミラールの影響, 麻酔, Vol.54, No.4, 364-369, 2005年. (要約) Nicorandil, a hybrid ATP-sensitive potassium (K(ATP)) channel opener and nitrate compound, is used clinically for the treatment of angina pectoris. In the present study, we investigated the effects of propofol and thiamylal on sarcolemmal K(ATP) channels activities induced by nicorandil in cultured rat aortic smooth muscle cells. We used inside-out patch clamp configurations to investigate the effects of propofol and thiamylal on nicorandil induced K(ATP) channel activities. K(ATP) channel was not spontaneously activated by patch excision in the absence of intracellular ATP. Application of nicorandil (100 microM) induced a marked activation of KATP channel currents, which was completely blocked by 3 microM glibenclamide, the sulfonylurea that blocks K(ATP) channels. Nicorandil induced KATP channel currents were not significantly inhibited by application of 10 and 100 microM propofol to intracellular surface. However, application of 100 and 300 microM thiamylal to intracellular surface significantly inhibited the nicorandil induced K(ATP) channel currents, with relative channel activities decreasing to 0.65 +/- 0.08 and 0.46 +/- 0.10 of control, respectively. Propofol had no effect on nicorandil induced sarcolemmal KATP channel activities in rat aortic smooth muscle cells, whereas thiamylal significantly inhibited these channel activities at clinically relevant concentrations. (キーワード) ニコランジル / プロポフォール / チアミラール / Kチャネル / パッチクランプ法 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15852621 ● CiNii @ 国立情報学研究所 (CRID): 1520009408034634624 ● Summary page in Scopus @ Elsevier: 2-s2.0-17644385814 (PubMed: 15852621, CiNii: 1520009408034634624, Elsevier: Scopus)
42.	大下修弘, 江口覚, 湯淺哲也, 舘原誠晃, 張剛太, 高石和美, 富岡重正, 中條信義 : 低カリウム血症により心電図異常を認めた糖尿病患者の1例, 日本歯科麻酔学会雑誌, Vol.33, No.1, 81-85, 2005年. (キーワード) HYPOPOTASSEMIA / ELECTROCARDIOGRAM / DIABETES MELLITUS (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573387449705597312 ● Summary page in Scopus @ Elsevier: 2-s2.0-13444282171 (CiNii: 1573387449705597312, Elsevier: Scopus)
43.	大下修弘, 江口覚, 高石和美, 張剛太, 金子美幸, 富岡重正, 中條信義 : 過去10年間の外科的矯正手術における体液管理と輸血準備の効率化についての検討, 四国歯学会雑誌, Vol.17, No.2, 243-251, 2005年. (キーワード) 顎矯正手術 / 体液管理 / 代用血漿剤 / 自己血輸血 / 最大手術血液準備量 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571980075768395648 (CiNii: 1571980075768395648)
44.	大下修弘, 江口覚, 久米景子, 湯淺哲也, 北村清一郎, 中條信義 : 全内臓逆位を伴った右胸心患者の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.32, No.3, 381-382, 2004年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1572261549961167872 (CiNii: 1572261549961167872)
45.	Satoru Eguchi, Kikuji Yamashita, Hiroyuki Morimoto, Tetsuo Ichikawa, Nobuyoshi Nakajo and Seiichiro Kitamura : Extracellular matrix formed by MC3T3-E1 osteoblast-like cells cultured on titanium 2. Collagen fiber formation, Connective Tissue, Vol.36, No.1, 9-15, 2004. (要約) Many aspects of the structures formed between titanium and cells and the mechanism of the formation are still unknown. In order to clarify these issues, we analyzed the initial structures formed between titanium and MC3T3-E1 osteoblast-like cells cultured on titanium. The present results indicate that extracellular matrix containing collagen fibers formed at the surface of a calcined layer on the titanium. At first, a hemispherical body and a small secondary spherical structure formed at the surface, followed by more beads to form a string-of-beads structure. These string-of-beads collagen structures elongated and formed spirals. For the first time ever, we directly observed the structure of collagen fiber formed between cultured osteoblasts and titanium with microscopy. Here, we describe the formation mechanism of type I collagen fibers in extracellular bone matrix. Elucidation of the mechanism of collagen fiber formation will aid in the development of controlled tissue regeneration. (キーワード) MC3T3-E1 / 細胞外マトリックス (extracellular matrix) / collagen fiber / spherical body / string-of-beads structure (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1543950420090628096 ● Summary page in Scopus @ Elsevier: 2-s2.0-2442611895 (CiNii: 1543950420090628096, Elsevier: Scopus)
46.	Kikuji Yamashita, Satoru Eguchi, Hiroyuki Morimoto, Takeo Hanawa, Tetsuo Ichikawa, Nobuyoshi Nakajo and Seiichiro Kitamura : Extracellular matrix formed by MC3T3-E1 osteoblast-like cells cultured on titanium 1. Anchor structure, Connective Tissue, Vol.36, No.1, 1-8, 2004. (要約) In order to clarify the structure of the extracellular matrix formed by osteoblasts in contact with titanium, we analyzed the structure formed by cultured clonal MC3T3-E1 osteoblasts on a calcified surface of commercial pure titanium, after exfoliating the cells from the surface of the titanium. Collagen fibers formed between neighboring cells and between cells and titanium, in the latter case with one tip of each collagen fiber bound to the cell and the other tip bound to the surface of the titanium embedded in the calcified layer. We called this structure an "anchor structure", because the collagen fibers embedded in the calcified layer anchor the cells to the titanium. This structure may be a reason for the useful biocompatibility between titanium and bone. (キーワード) MC3T3-E1 / 細胞外マトリックス (extracellular matrix) / チタン (titanium) / type I collagen / anchor structure (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1543668945113917440 ● Summary page in Scopus @ Elsevier: 2-s2.0-2442601411 (CiNii: 1543668945113917440, Elsevier: Scopus)
47.	大下修弘, 江口覚, 工藤景子, 湯淺哲也, 中條信義 : 2ヶ月で2度，全身麻酔を受けた超高齢者の1例, 日本歯科麻酔学会雑誌, Vol.32, No.2, 250-251, 2004年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570854175126888320 ● Summary page in Scopus @ Elsevier: 2-s2.0-2442494141 (CiNii: 1570854175126888320, Elsevier: Scopus)
48.	大下修弘, 江口覚, 中條信義, 湯淺哲也, 鎌田伸之 : フェンタニルとプロポフォールの持続静脈内投与で術後管理を行った精神発達遅滞を伴う小児患者の1例, 臨床麻酔, Vol.28, No.4, 725-728, 2004年. (キーワード) 精神発達遅滞 / 術後管理 / フェンタニル (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573950401507880704 (CiNii: 1573950401507880704)
49.	北岡栄一郎, 富岡重正, 大下修弘, 野村美幸, 高石和美, 江口覚, 中條信義 : 徳島大学歯学部付属病院歯科麻酔科外来における過去17年間の臨床統計的観察, 日本歯科麻酔学会雑誌, Vol.31, No.3, 309-310, 2003年.
50.	北岡栄一郎, 富岡重正, 大下修弘, 野村美幸, 高石和美, 江口覚, 中條信義 : 徳島大学歯学部附属病院歯科麻酔外来における過去17年間の臨床統計的観察, 日本歯科麻酔学会雑誌, Vol.31, No.3, 309-310, 2003年.
51.	高石和美, 野村美幸, 大下修弘, 三久富子, 江口覚, 富岡重正, 中條信義 : Sturge-Weber 症候群患者の精神鎮静法経験, 日本歯科麻酔学会雑誌, Vol.29, No.5, 633-634, 2001年.
52.	江口覚, 大下修弘, 三久富子, 高石和美, 富岡重正, 中條信義 : リドカインの味覚刺激の種類についての検討, 第28回日本歯科麻酔麻酔学会総会, 2000年.
53.	富岡重正, 大下修弘, 栗尾富子, 高石和美, 江口覚, 中條信義 : 歯科治療時の静脈内鎮静法における呼気ガスサンプリングチューブNAZORCAP^TM の有用性, 日本歯科麻酔学会雑誌, Vol.28, No.2, 223-226, 2000年. (キーワード) NAZORCAP / INTRAVENOUS SEDATION / DENTAL THERAPY / PETCO 2 / Paco 2 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570572699612708096 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034037607 (CiNii: 1570572699612708096, Elsevier: Scopus)
54.	大下修弘, 富岡重正, 江口覚, 栗尾富子, 高石和美, 中條信義 : Schwartz-Jampel syndrome 患者の歯科麻酔経験, 日本歯科麻酔学会雑誌, Vol.28, No.2, 267-268, 2000年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570291224635828480 (CiNii: 1570291224635828480)
55.	Shigemasa Tomioka, Daisuke Uchida, Satoru Eguchi and Nobuyoshi Nakajo : Elimination of hypersensitive gagging reaction to dentistry by propofol at subhypnotic doses, Oral Diseases, Vol.4, 279-280, 1998. (キーワード) propofol / subhypnotic dose / gagging reflex
56.	Shigemasa Tomioka, Satoru Eguchi, Naoko Bando and Nobuyoshi Nakajo : Effects of Midazolam and Flumazenil on Reflex Potentials of the Hypoglossal Nerve Evoked by Stimulation of the Palate, Dentistry in Japan, Vol.32, 116-119, 1995. (キーワード) Palate / Hypoglossal nerve / Reflex potential / Midazolam / Flumazenil

学術論文(紀要・その他):

1.	篠島理, 高石和美, 西川美佳, 武川香織, 福本仁美, 髙田真里菜, 髙田香, 藤原茂樹, 江口覚, 川人伸次 : 歯科治療後に敗血症性肺塞栓症を発症し院内迅速対応システムに基づき早期介入を行った症例, 日本歯科麻酔学会雑誌, Vol.51, 199, 2023年.
2.	髙田真里菜, 藤原茂樹, 篠島理, 西川美佳, 江口覚, 髙田香, 富山栞, 加山実優, 高石和美, 川人伸次 : Ia 型総肺静脈還流異常症術後の口腔外科手術時の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.51, 172, 2023年.
3.	西川美佳, 江口覚, 篠島理, 髙田真里菜, 髙田香, 藤原茂樹, 高石和美, 川人伸次 : QTc 延長を伴ったクレアチントランスポーター欠損症患者の全身麻酔経験, 日本歯科麻酔学会雑誌, Vol.51, 163, 2023年.

総説・解説:

1.	高石和美, 藤原茂樹, 江口覚, 大塚良, 赤澤友基, 北村尚正, 上田(山口) 公子, 中川弘, 可児耕一, 青田桂子, 桃田幸弘, 山村佳子, 工藤景子, 大江剛, 玉谷哲也, 宮本洋二, 東雅之, 岩本勉, 北畑洋 : 当院における全身麻酔下歯科治療について -障害をもつ方へ安全な歯科治療の提供-, Journal of Oral Health and Biosciences, Vol.31, No.1, 62-67, 2018年7月. (要約) We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs. (キーワード) 全身麻酔 / 障害者 / 日帰り全身麻酔 / 歯科治療 (徳島大学機関リポジトリ) ● Metadata: 111940 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.31.1_62 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390845712973457920 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_62 (徳島大学機関リポジトリ: 111940, DOI: 10.20738/johb.31.1_62, CiNii: 1390845712973457920)
2.	江口覚 : 歯科局所麻酔薬アレルギーが疑われた患者への対応, 四国歯学会誌, Vol.27, No.1, 41-47, 2014年6月. (徳島大学機関リポジトリ) ● Metadata: 109853 (徳島大学機関リポジトリ: 109853)

国際会議:

1.	Kazumi Takaishi, Tomohiro Aoyama, Shigeki Fujiwara Joseph Luke, Ryo Otsuka, Satoru Eguchi, Yasuo Tsutsumi, Shinji Kawahito, Hiroyuki Kinoshita and Hiroshi Kitahata : Pleth Variability Index Predicts Hemodynamic Derangements In Patients Undergoing Oral Surgery, The Anesthesiology 2019 Annual Meeting, Orando USA, Oct. 2019.
2.	Shigeki Fujiwara Joseph Luke, K Tachihara, S Mori, 大塚良, T Yamamoto, Satoru Eguchi, Kazumi Takaishi, I Toyoguchi, Jin-Ping Ao and Hiroshi Kitahata : Influence of PTS stopcock status on the natural frequency of blood pressure‒transducer kits, Joint Conference of IFDAS2018-FADAS2018-JDSA46, Nara, Oct. 2018.
3.	山本剛士, Kazumi Takaishi, 大塚良, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Tomohiro Soga, Shinji Kawahito and Hiroshi Kitahata : Three‒dimensional computed tomography and nasopharyngoscopy for nasotracheal intubation after pharyngeal flap construction, Joint Conference of IFDAS2018-FADAS2018-JDSA46, Nara, Oct. 2018.
4.	Kazumi Takaishi, s Satomi, Naoji Mita, T Yamamoto, 大塚良, Satoru Eguchi, Shigeki Fujiwara Joseph Luke, Shinji Kawahito, H Kinoshita and Hiroshi Kitahata : Rapamycin becomes the sevoflurane vasodilator effect apparent in the rat artery, Joint Conference of IFDAS2018-FADAS2018-JDSA46, Nara, Oct. 2018.
5.	Watananbe S, Takashi Kawano, Satoru Eguchi, Iwata H, Yamanaka D, Locatelli FM, Kataoka H, Htakeyama Y, Okuhara Y and Yokoyama M : Dynamic Behavior of Perioperative Uric Acid Levels for Early Prediction of Postoperative Acute Kidney Injury: A Single-center Retrospective Database Analysis, The Annual Meeting of the American Society of Anesthesiologists, Oct. 2016.
6.	Kaminaga S, Takashi Kawano, Satoru Eguchi, Yamanaka D, Iwata H and Yokoyama M : Pregabalin can prevent but not reverse cognitive dysfunction following abdominal surgery in a rat model., INTERNATIONAL ANESTHESIA RESEARCH SOCIETY 2015 Annual Meeting, Mar. 2015.
7.	Kazumi Takaishi, Shinji Kawahito, Aoyama Tomohiro, Otsuka Ryo, Naoji Mita, Satoru Eguchi, Shigemasa Tomioka and Hiroshi Kitahata : The effects of ketamine on the release of vascular endothelial growth factor and in vitro capillary tube formation., The 7th Annual Meeting of the Federation of Asian Dental Anesthesiology Societies, Niigata, Oct. 2014.
8.	D Yamanaka, T Kawano, T Takahashi, H Iwata, S Imori, A Mrokawa, S Waki, Satoru Eguchi and M Yokoyama : Preoperative Cognitive Intervention Can Prevent the Development of Spatial Memory Impairment After Abdominal Surgery in Aged Rats., ANESTHESIOLOGY 2014 annual meeting, Oct. 2014.
9.	Kazumi Takaishi, Shinji Kawahito, Naoji Mita, Satoru Eguchi, Shigemasa Tomioka and Hiroshi Kitahata : The effects of intravenous anesthetics on in vitro angiogenesis and cell proliferation., Euroanaesthesia 2013, Barcelona, Jun. 2013.
10.	Daiki Yamanaka, Takashi Kawano, Satoru Eguchi, Haidong Chi, Hideki Iwata, Fumimoto Yamazaki and Masataka Yokoyama : Effects of Dexmedetomidine on Insulin Secretion From Rat Pancreatic Cells, The Annual Meeting of the American Society of Anesthesiologists, Oct. 2012.
11.	Takashi Kawano, Haidong Chi, Hideki Iwata, Satoru Eguchi, Daiki Yamanaka, Fumimoto Yamazaki and Masataka Yokoyama : Isoflurane Modulates Microglial Function Via the Activation of ATP-Sensitive Potassium Channels, The Annual Meeting of the American Society of Anesthesiologists, Oct. 2012.
12.	Kazumi Takaishi, Shinji Kawahito, Nakamura Dai, Tatsuishi Tomoko, Satoru Eguchi, Shigemasa Tomioka and Hiroshi Kitahata : The effects of intravenous anesthetics on the release of vascular endothelial growth factor and angiogenesis., Euroanaesthesia 2012, Paris, Jun. 2012.
13.	Maeda Yoshiko, Sonoe Kitamura, Takashi Kawano, Satoru Eguchi and Chi Haidong : Anti-hyperalgesic Effects of the Neurosteroid Allopregnanolone in neuropathic rats., Anesthesiology 2011(Chicago), Nov. 2011.
14.	Takashi Kawano, Satoru Eguchi, Haidong Chi, Kentaro Yamamoto, Fumimoto Yamazaki and Masataka Yokoyama : Interaction of Glucagon-Like Peptide-1 with Isoflurane on Insulin Secretion in Rat., Anesthesiology 2011(Chicago), Nov. 2011.
15.	Yoshinobu Tomiyama, Yamaguchi Mikiyo, Satoru Eguchi, Hiroshi Kitahata and Shuzo Oshita : Effects of propofol on the changes in membrane potential induced by simulated ischemia/reperfusion by means of mitochondrial uncoupler in cultured human coronary artery endothelial cells., The Annual Meeting of the American Society of Anesthesiologists, Atlanta, Oct. 2005.
16.	湯淺哲也, 大下修弘, 鎌田伸之, 江口覚, 舘原誠晃, 里村一人, 長山勝 : 顎裂閉鎖術を行った精神発達遅滞患者の 1例, 6th Asian Congress on Oral and Maxillofacial Surgery，第49回日本口腔外科学会総会, 千葉, 2004年10月.

国内講演発表:

1.	篠島理, 高石和美, 西川美佳, 武川香織, 福本仁美, 髙田真里菜, 髙田香, 藤原茂樹, 江口覚, 川人伸次 : 歯科治療後に敗血症性肺塞栓症を発症し院内迅速対応システムに基づき早期介入を行った症例, 第51回日本歯科麻酔学会総会・学術集会, 2023年10月.
2.	髙田真里菜, 藤原茂樹, 篠島理, 西川美佳, 江口覚, 髙田香, 富山栞, 加山実優, 高石和美, 川人伸次 : Ia 型総肺静脈還流異常症術後の口腔外科手術時の全身麻酔経験, 第51回日本歯科麻酔学会総会・学術集会, 2023年10月.
3.	西川美佳, 江口覚, 篠島理, 髙田真里菜, 髙田香, 藤原茂樹, 高石和美, 川人伸次 : QTc 延長を伴ったクレアチントランスポーター欠損症患者の全身麻酔経験, 第51回日本歯科麻酔学会総会・学術集会, 2023年10月.
4.	西川美佳, 藤原茂樹, 髙田真里菜, 加山実優, 富山栞, 篠島理, 髙田香, 江口覚, 斎藤昌司, 高石和美, 川人伸次 : 後天性血友病患者の全身管理経験, 第37回中国・四国歯科麻酔研究会, 2023年8月.
5.	髙田真里菜, 藤原茂樹, 篠島理, 西川美佳, 加山美優, 富山栞, 髙田香, 江口覚, 斎藤昌司, 高石和美, 川人伸次 : 開口障害を伴うGorlin症候群患者の口腔外科手術時にGLIDESCOPE Coreモニターシステムによる気管挿管が有効であった1例, 第37回中国・四国歯科麻酔研究会, 2023年8月.
6.	加山実優, 藤原茂樹, 富山栞, 篠島理, 髙田真里菜, 西川美佳, 髙田香, 江口覚, 斎藤昌司, 高石和美, 川人伸次 : 運動誘発性喘息患児に対する口腔外科手術時の静脈麻酔併用静脈内鎮静法管理の 1 例, 第37回中国・四国歯科麻酔研究会, 2023年8月.
7.	藤原茂樹, 篠島理, 髙田真里菜, 西川美佳, 江口覚, 髙田香, 高石和美, 川人伸次 : 鎮静薬に抵抗を示した過換気症候群患者の口腔外科手術時の麻酔経験, 第50回日本歯科麻酔学会総会・学術集会, 2022年10月.
8.	篠島理, 藤原茂樹, 髙田真里菜, 西川美佳, 江口覚, 髙田香, 高石和美, 川人伸次 : Gilbert 症候群患者の口腔外科手術時の全身麻酔経験, 第50回日本歯科麻酔学会総会・学術集会, 2022年10月.
9.	西川美佳, 藤原茂樹, 篠島理, 髙田真里菜, 江口覚, 髙田香, 斎藤昌司, 高石和美, 川人伸次 : 遺伝性出血性毛細血管拡張症患者に対する歯科治療時の周術期管理の1例, 第36回中国・四国歯科麻酔研究会プログラム, 2022年8月.
10.	髙田真里菜, 藤原茂樹, 江口覚, 篠島理, 西川美佳, 髙田香, 斎藤昌司, 高石和美, 川人伸次 : 開口障害を伴う筋突起および側頭筋腱膜過形成症患者の口腔外科手術時にGLIDESCOPE Coreモニターシステムによる気管挿管が有効であった1例, 第36回中国・四国歯科麻酔研究会プログラム, 2022年8月.
11.	篠島理, 藤原茂樹, 髙田真里菜, 西川美佳, 江口覚, 髙田香, 高石和美, 川人伸次 : 食物依存性運動アナフィラキシー患者に対する口腔外科手術時の静脈麻酔併用静脈内鎮静法管理の 1 例, 第36回中国・四国歯科麻酔研究会プログラム, 2022年8月. (キーワード) 症例報告
12.	西川美佳, 高田真里菜, 篠島理, 藤原茂樹, 高石和美, 江口覚, 箕田直治, 髙田香, 曽我朋宏, 木下浩之, 川人伸次 : 心肺蘇生時におけるクアドラライト麻酔用マスクの有用性の検討, 日本循環制御医学会総会プログラム・抄録集43回, 2022年5月.
13.	篠島理(徳島大学病院歯科麻酔科), 高田真里菜, 西川美佳, 藤原茂樹, 高石和美, 江口覚, 箕田直治, 髙田香, 曽我朋宏, 木下浩之, 川人伸次 : 下咽頭梨状窩瘻に対し化学的焼灼術を施行した1症例, 日本循環制御医学会総会プログラム・抄録集43回, 2022年5月.
14.	高田真里菜, 西川美佳, 篠島理, 藤原茂樹, 高石和美, 江口覚, 箕田直治, 髙田香, 曽我朋宏, 木下浩之, 川人伸次 : 複数回の再手術を要した血友病Bの1症例, 日本循環制御医学会総会プログラム・抄録集43回, 2022年5月.
15.	江口覚, 川人伸次 : 小児の神経発達に及ぼす全身麻酔と体外循環の影響, 日本小児麻酔学会誌, Vol.27, No.suppl, 65, 2022年.
16.	篠島理, 藤原茂樹, 髙田真里菜, 西川美佳, 青木理紗, 江口覚, 高石和美, 北畑洋 : 局所麻酔下歯科治療後にアレルギー反応を繰り返したSjögren症候群患者の全身管理経験, 第49回日本歯科麻酔学会総会・学術集会, 2021年10月.
17.	青木理紗, 髙田真里菜, 篠島理, 西川美佳, 大塚拓, 藤原茂樹, 江口覚, 長宗雅美, 赤池雅史, 高石和美, 北畑洋 : 気管挿管手技における気道管理シミュレータ4種類の比較, 第49回日本歯科麻酔学会総会・学術集会, 2021年10月.
18.	武川香織, 高石和美, 真杉幸江, 長岡仁美, 鶴田真生, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 歯科治療時に全身的偶発症/合併症を発症した8 症例:患者急変時に歯科衛生士ができる対応, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
19.	江口覚, 西川美佳, 青木理紗, 藤原茂樹, 高石和美, 北畑洋 : 全身麻酔の術中検査でクレアチンキナーゼ(CK)の異常高値を認めた1 症例, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
20.	髙田真里菜, 川人伸次, 相良亘, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 高石和美, 北畑洋 : カルバマゼピン継続困難な高齢三叉神経痛患者の治療, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
21.	相良亘, 川人伸次, 髙田真里菜, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 高石和美, 北畑洋 : 小柴胡湯・桂枝加芍薬湯併用療法が有効であった三叉神経帯状疱疹後神経痛の2 症例, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
22.	西川美佳, 藤原茂樹, 青木理紗, 江口覚, 高石和美, 大塚拓, 吉田雅彦, 李楊, 敖金平, 北畑洋 : ワイヤレス給電式医療機器の開発―2.45 GHz 帯域 Ver. 1―, 第48回日本歯科麻酔学会総会・学術集会, 2020年10月.
23.	高石和美, 川人伸次, 大塚良, 藤原茂樹, 江口覚, 北畑洋 : 鉄貯蔵蛋白からの鉄イオン遊離に関与する還元物質について, 第47回日本歯科麻酔学会総会・学術集会, 2019年10月.
24.	青木一希, 藤原茂樹, 中尾俊介, 李楊, 大塚良, 江口覚, 高石和美, 敖金平, 立原敬一, 北畑洋 : オープンリング共振器を使用した医療機器への無線電力伝送について, 第47回日本歯科麻酔学会総会・学術集会, 2019年10月.
25.	大塚良, 山本剛士, 藤原茂樹, 江口覚, 高石和美, 北畑洋 : 喉頭蓋囊胞を有する6症例の全身麻酔経験, 第46回日本歯科麻酔学会総会・学術集会, 2018年10月.
26.	江口覚, 山本剛士, 大塚良, 藤原茂樹, 高石和美, 大塚拓, 吉田雅彦, 北畑洋 : 高齢患者における皮弁を用いた頭頸部再建術の全身麻酔症例の検討, 第46回日本歯科麻酔学会総会・学術集会, 2018年10月.
27.	尾上真奈美, 大塚良, 藤原茂樹, 江口覚, 高石和美, 吉田雅彦, 北畑洋 : 母指内転筋および皺眉筋で筋弛緩モニタリングを行った眼筋型重症筋無力症患者の全身麻酔経験, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
28.	大塚良, 高石和美, 尾上真奈美, 江口覚, 藤原茂樹, 青山智祐, 足立奈由香, 丹羽均, 北畑洋 : 水無脳症患者の歯科治療時の全身麻酔経験, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
29.	江口覚, 尾上真奈美, 大塚拓, 大塚良, 藤原茂樹, 高石和美, 北畑洋 : 血管迷走神経反射既往患者の静脈路確保にミダゾラム経口投与が有用であった1例, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
30.	高石和美, 川人伸次, 尾上真奈美, 大塚良, 江口覚, 藤原茂樹, 北畑洋 : デクスメデトミジンが細胞増殖と細胞遊走に与える影響について, 第45回歯科麻酔学会総会·学術集会, 2017年10月.
31.	藤原茂樹, 大内謙太郎, 尾上真奈美, 大塚良, 江口覚, 高石和美, 北畑洋 : 従来のmodified Mallampati分類および独自に考案したRe modified Mallampati分類とCormack Lehane分類との比較(第二報), 第45回歯科麻酔学会総会·学術集会, 2017年10月.
32.	江口覚, 尾上真奈美, 大塚良, 高石和美, 富岡重正, 北畑洋 : 研修歯科医に対する下顎孔伝達麻酔シミュレーション教育の有用性, 第44回日本歯科麻酔学会総会・学術集会, 2016年10月.
33.	大塚良, 尾上真奈美, 江口覚, 高石和美, 富岡重正, 北畑洋 : 小胞体ストレス応答においてGADD34のC端末は細胞増殖を調整する, 第44回日本歯科麻酔学会総会・学術集会, 2016年10月.
34.	高石和美, 青山智祐, 尾上真奈美, 大塚良, 江口覚, 富岡重正, 川人伸次, 北畑洋 : 口腔外科手術患者の術前心電図における早期再分極およびQT延長の頻度と周術期の経過について, 第44回日本歯科麻酔学会総会・学術集会, 2016年10月.
35.	尾上真奈美, 富岡重正, 大塚良, 高石和美, 江口覚, 北畑洋 : 血管迷走神経反射により2度心停止が生じた症例について考える, 第31回中国・四国歯科麻酔研究会, 2016年7月.
36.	大塚良, 江口覚, 尾上真奈美, 高石和美, 富岡重正, 北畑洋 : 術前検査で発見されたフォン・ウィルブランド病患者の鎮静経験, 第31回中国・四国歯科麻酔研究会, 2016年7月.
37.	高石和美, 川人伸次, 青山智祐, 尾上真奈美, 大塚良, 江口覚, 富岡重正, 箕田直治, 曽我朋宏, 堤保夫, 木下浩之, 北畑洋 : 術前12誘導心電図におけるJ波出現と周術期の経過について, 第37回日本循環制御医学会総会, 2016年7月.
38.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 北畑洋 : セボフルランが原因と考えられる術後肝機能障害を生じた1例, 第43回日本歯科麻酔学会総会・学術大会, 2015年11月.
39.	高石和美, 川人伸次, 青山智祐, 大塚良, 江口覚, 富岡重正, 北畑洋 : ヒト臍帯静脈血管内皮細胞において静脈麻酔薬が細胞遊走に与える影響, 第43回日本歯科麻酔学会総会・学術大会, 2015年10月.
40.	江口覚, 高石和美, 北畑洋 : 新たに開発した神経ブロックシミュレータを用いた学生教育, 日本臨床麻酔学会第35回大会, 2015年10月.
41.	大塚良, 青山智祐, 江口覚, 高石和美, 富岡重正, 北畑洋 : 気管挿管時に発見した喉頭蓋嚢胞の2 症例, 第30回中国·四国歯科麻酔研究会, 2015年6月.
42.	江口覚, 青山智祐, 大塚良, 高石和美, 富岡重正, 北畑洋 : 下顎孔伝達麻酔・局所浸潤麻酔シミュレーションモデルの開発, 第30回中国·四国歯科麻酔研究会, 2015年6月.
43.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 箕田直治, 曽我朋宏, 川人伸次, 北畑洋 : 長時間の口腔外科手術における循環モニタリングの変遷, 第30回中国·四国歯科麻酔研究会, 2015年6月.
44.	青山智祐, 高石和美, 大塚良, 江口覚, 富岡重正, 北畑洋 : 特発性間質性肺炎を合併した患者に対する長時間手術の全身麻酔経験, 第42回日本歯科麻酔学会総会・学術集会, 2014年10月.
45.	大塚良, 富岡重正, 桃田幸弘, 青山智祐, 高石和美, 江口覚, 北畑洋 : 血管迷走神経反射による失神時に心拍変動解析を行った1症例, 第42回日本歯科麻酔学会総会・学術集会, 2014年10月.
46.	富岡重正, 青山智祐, 大塚良, 高石和美, 江口覚, 北畑洋 : 骨髄由来間葉系幹細胞から分化誘導した幼若神経細胞に対するリドカインの作用について, 第42回日本歯科麻酔学会総会・学術集会, 2014年10月.
47.	長井佳香, 清水宗, 高石和美, 青山智祐, 大塚良, 鎌田久美子, 江口覚, 富岡重正, 早雲講二, 北畑洋 : 歯科治療中の全身的偶発症に関するアンケート調査, 第29回中国・四国歯科麻酔研究会, 2014年7月.
48.	青山智祐, 江口覚, 大塚良, 鎌田久美子, 高石和美, 富岡重正, 北畑洋 : 歯科治療終了後に血管迷走神経反射を生じた一例, 第29回中国・四国歯科麻酔研究会, 2014年7月.
49.	大塚良, 富岡重正, 桃田幸弘, 高野栄之, 青山智祐, 鎌田久美子, 高石和美, 江口覚, 北畑洋 : 体位性起立頻拍症候群患者の抜歯時自律神経活動を測定した一例, 第29回中国・四国歯科麻酔研究会, 2014年7月.
50.	鎌田久美子, 高石和美, 高橋章, 工藤隆治, 青山智祐, 大塚良, 江口覚, 富岡重正, 北畑洋 : 気管切開後気管狭窄を有する患者の全身麻酔経験, 第29回中国・四国歯科麻酔研究会, 2014年7月.
51.	江口覚, 青山智祐, 大塚良, 高石和美, 富岡重正, 北畑洋 : カルバマゼピン投与により薬疹と意識消失発作を呈した三叉神経痛の1例, 第41回日本歯科麻酔学会総会・学術集会, 2013年10月.
52.	高石和美, 川人伸次, 青山智祐, 大塚良, 江口覚, 富岡重正, 北畑洋 : ミダゾラムがin vitro血管新生に与える影響, 第41回日本歯科麻酔学会総会・学術集会, 2013年10月.
53.	富岡重正, 桃田幸弘, 青山智祐, 大塚良, 高石和美, 江口覚, 北畑洋 : 心拍変動解析を行った起立性調節障害の1症例, 第41回日本歯科麻酔学会総会・学術集会, 2013年10月.
54.	大塚良, 江口覚, 宮田恵, 青山智裕, 高石和美, 富岡重正, 北畑洋 : 術前の多剤降圧薬内服が原因とみられる麻酔導入後低血圧を認めた1例, 第28回中国・四国歯科麻酔研究会, 2013年7月.
55.	青山智裕, 富岡重正, 宮田恵, 大塚良, 高石和美, 江口覚, 北畑洋 : 重症心疾患を有する患者に対する舌癌手術の麻酔管理, 第28回中国・四国歯科麻酔研究会, 2013年7月.
56.	宮田恵, 高石和美, 青山智裕, 大塚良, 江口覚, 富岡重正, 北畑洋 : 気管挿管練習用モデルでの3種類の喉頭鏡(Macintosh型喉頭鏡，エアウェイスコープ®, McGRATH® )の使用比較, 第28回中国・四国歯科麻酔研究会, 2013年7月.
57.	山崎史幹, 河野崇, Haidong Chi, 江口覚, 山本佳子, 横山正尚 : ラット神経障害性痛モデルの痛覚過敏様行動に対するリハビリテーションの効果, 日本麻酔科学会第60回学術集会, 2013年5月.
58.	富岡重正, 桃田幸弘, 古北まゆ子, 立石智子, 高瀬奈緒, 高石和美, 江口覚, 北畑洋 : 局所浸潤麻酔のストレスによって誘発された蕁麻疹の1例, 第40回日本歯科麻酔学会総会・学術集会, 2012年10月.
59.	高石和美, 川人伸次, 立石智子, 古北まゆ子, 高瀬奈緒, 江口覚, 富岡重正, 北畑洋 : プロポフォールが血管内皮細胞増殖因子産生と血管新生に与える影響, 第40回日本歯科麻酔学会総会・学術集会, 2012年10月.
60.	大西杏奈, 宮前雅, 金田一弘, 大草知佳, 稲村吉高, 塩見真由美, 越沼静, 小谷順一郎, 高瀬奈緒, 古北まゆ子, 立石智子, 高石和美, 江口覚, 富岡重正, 北畑洋 : セボフルレン・エタノールによる心筋プレコンディショニングの細胞内メカニズムの解明, 第27回中国・四国歯科麻酔研究会, 2012年7月.
61.	江口覚, 高瀬奈緒, 古北まゆ子, 立石智子, 大西杏奈, 高石和美, 富岡重正, 北畑洋 : 下顎骨再建術後の挿管困難が予想された患者に対してエアウェイスコープを用いた意識下挿管の経験, 第27回中国・四国歯科麻酔研究会, 2012年7月.
62.	高瀬奈緒, 高石和美, 古北まゆ子, 立石智子, 大西杏奈, 江口覚, 富岡重正, 北畑洋 : 過去2年間に術前検査でBrugada型心電図を認めた症例, 第27回中国・四国歯科麻酔研究会, 2012年7月.
63.	立石智子, 富岡重正, 古北まゆ子, 高瀬奈緒, 大西杏奈, 江口覚, 北畑洋 : 尋常性天疱瘡患者における頬粘膜腫瘍切除術の全身麻酔経験, 第27回中国・四国歯科麻酔研究会, 2012年7月.
64.	河野崇, Haidong Chi, 江口覚, 清水友理, 横瀬美里, 横山正尚 : 急性術後痛モデルラットを用いたオピオイドの鎮痛用量と嘔吐の関係の検討, 日本麻酔科学会第59回学術集会, 2012年6月.
65.	河野崇, Haidong Chi, 江口覚, 立岩浩規, 田村貴彦, 横山正尚 : ラット脳ミクログリアにおけるATP感受性Kイオンチャネルの機能的発現と揮発性麻酔薬の影響, 日本麻酔科学会第59回学術集会, 2012年6月.
66.	高石和美, 立石智子, 江口覚, 北畑洋 : Brugada型心電図を呈した6症例の術前評価と麻酔経過の検討, 第31回日本臨床麻酔学会(宜野湾市), 2011年11月.
67.	立石智子, 高石和美, 郷律子, 江口覚, 北畑洋 : 小手術を施行した薬剤溶出性ステント留置患者の周術期管理に関する検討, 第31回日本臨床麻酔学会(宜野湾市), 2011年11月.
68.	富岡重正, 立石智子, 榎本奈実, 古北まゆ子, 中村大, 高石和美, 江口覚, 北畑洋 : 脳内グルコーストランスポーターの水輸送機能に対する温度の影響について, 第39回日本歯科麻酔学会総会・学術集会, 2011年10月.
69.	立石智子, 高石和美, 中村大, 古北まゆ子, 榎本奈実, 江口覚, 富岡重正, 北畑洋 : 術前の頸動脈評価が有用であった2症例, 第39回日本歯科麻酔学会総会・学術集会, 2011年10月.
70.	榎本奈実, 富岡重正, 中村大, 立石智子, 古北まゆ子, 高石和美, 江口覚, 北畑洋 : 全身麻酔後に過換気発作を起こした2症例, 第26回中国・四国歯科麻酔研究会, 2011年7月.
71.	中村大, 江口覚, 立石智子, 古北まゆ子, 榎本奈実, 高石和美, 富岡重正, 北畑洋 : 徳島大学病院歯科外来における救急対応について, 第26回中国・四国歯科麻酔研究会, 2011年7月.
72.	宮崎陽子, 山下菊治, 江口覚, 上馬塲和夫, 高岡英人, 大野照旺 : 歯科医療におけるヘッドケアの効果の検討, 第14回日本総合医療学会, 2010年12月.
73.	榎本奈実, 高石和美, 江口覚, 富岡重正, 北畑洋 : 口腔外科手術が施行された冠動脈血行再建術既往患者に関する検討, 日本歯科麻酔学会総会・学術集会, 2010年10月.
74.	富岡重正, 高石和美, 江口覚, 北畑洋 : グルコーストランスポーター3の糖輸送機能と水輸送機能に対するペントバルビタールの作用, 日本歯科麻酔学会総会・学術集会, 2010年10月.
75.	江口覚, 高石和美, 富岡重正, 北畑洋 : 徳島大学病院歯科麻酔科外来における手術情報管理システム(ORSYS)導入, 第25回中国・四国歯科麻酔研究会, 2010年7月.
76.	立石智子, 高石和美, 江口覚, 富岡重正, 北畑洋 : FloTracによるStroke volume variation)を指標として循環管理を行った3症例, 第25回中国・四国歯科麻酔研究会, 2010年7月.
77.	榎本奈実, 江口覚, 高石和美, 富岡重正, 北畑洋 : DAM(difficult airway management)カートの手術部設置について, 第25回中国・四国歯科麻酔研究会, 2010年7月.
78.	富岡重正, 榎本奈実, 岩田英道, 中井恵, 高石和美, 江口覚 : アフリカツメガエル卵母細胞に発言したアクアポリン5に対する局所麻酔薬の作用, 第37回日本歯科麻酔学会総会・学術集会, 2009年10月.
79.	岩田英道, 江口覚, 中井恵, 榎本奈実, 高石和美, 富岡重正 : レミフェンタニルの全身麻酔後に短時間のシバリングを認めた1例, 第37回日本歯科麻酔学会総会・学術集会, 2009年10月.
80.	富岡重正, 榎本奈実, 岩田英道, 中井恵, 高石和美, 江口覚 : 過換気症候群にβ遮断薬が有効であった症例第2報, 第6回日本歯科麻酔学会中国・四国地方会, 2009年7月.
81.	榎本奈実, 岩田英道, 中井恵, 高石和美, 江口覚, 富岡重正 : Duchenne型筋ジストロフィー患者の歯科治療時の全身管理経験, 第6回日本歯科麻酔学会中国・四国地方会, 2009年7月.
82.	富岡重正, 高石和美, 江口覚 : セロトニントランスポーターに対するn-alcoholsの抑制作用にみられたcut off現象, 第36回日本歯科麻酔学会総会学術集会, 2008年10月.
83.	富塚佳史, 富岡重正, 金子美幸, 張剛太, 高石和美, 江口覚, 中條信義 : アスピリン喘息患者の鎮痛薬選択にin Vitroリンパ球幼若化検査を用いた2症例, 第2回日本歯科麻酔学会中国・四国地方会, 2005年7月.
84.	高石和美, 張剛太, 金子美幸, 富塚佳史, 江口覚, 富岡重正, 中條信義 : 学生と卒業生に対する救急蘇生実習後の知識およびアンケート調査, 第2回日本歯科麻酔学会中国・四国地方会, 2005年7月.
85.	富岡重正, 金子美幸, 高石和美, 張剛太, 江口覚, 富塚佳史, 中條信義 : β遮断薬が有効であった過換気症候群患者の一例, 第2回日本歯科麻酔学会中国・四国地方会, 2005年7月.
86.	張剛太, 富岡重正, 江口覚, 高石和美, 大下修弘, 金子美幸, 中條信義 : 学生の臨床実習中におけるストレス反応, 第32回日本歯科麻酔学会, 2004年10月.
87.	大下修弘, 高石和美, 江口覚, 張剛太, 野村美幸, 富岡重正, 中條信義 : スポーツマン高校生の全身麻酔経験, 第32回日本歯科麻酔学会, 2004年10月.
88.	大下修弘, 江口覚, 中條信義, 竹村元秀 : 三叉神経降圧反応を誘導する神経基盤, 第27回日本神経科学大会, 2004年9月.
89.	高石和美, 富岡重正, 江口覚, 大下修弘, 張剛太, 中條信義 : 沖縄県重度心身障害者全身麻酔下歯科治療事業に参加して, 第2回日本歯科麻酔学会中国・四国地方会, 2004年7月.
90.	大下修弘, 富岡重正, 江口覚, 高石和美, 張剛太, 中條信義 : 低カリウム血症により心電図異常を認めた糖尿病患者の1症例, 第1回日本歯科麻酔学会中国・四国地方会, 2004年7月.
91.	江口覚, 山下菊治, 石川友康, 富山芳信, 大下修弘, 細川浩良, 北村清一郎, 中條信義 : 遠赤外線照射は麻酔効果を抑制する, 第22回麻酔メカニズム研究会, 2004年7月.
92.	大下修弘, 江口覚, 高石和美, 野村美幸, 富岡重正, 中條信義 : PCAによる術後疼痛管理を行った精神発達遅滞を伴う小児患者の一例, 第31回日本歯科麻酔学会総会, 2003年9月.
93.	野村美幸, 富岡重正, 江口覚, 高石和美, 大下修弘, 中條信義 : リドカインのグルコーストランスポーター Type3 に対する作用, 第31回日本歯科麻酔学会総会, 2003年9月.
94.	大下修弘, 江口覚, 高石和美, 野村美幸, 富岡重正, 中條信義 : 過去10年間における顎矯正手術の輸血準備量の検討, 第18回中国・四国歯科麻酔研究会, 2003年7月.
95.	高石和美, 中條信義, 富岡重正, 江口覚, 大下修弘, 野村美幸, 横山和博, 芦田有紀 : 発作性心房細動の症例, 第18回中国・四国歯科麻酔研究会, 2003年7月.
96.	高石和美, 中條信義, 富岡重正, 江口覚, 大下修弘, 野村美幸 : 家族性にCICR速度亢進を認めた症例, 第30回日本歯科麻酔学会総会, 2002年9月.
97.	大下修弘, 江口覚, 高石和美, 野村美幸, 富岡重正, 中條信義 : ネコ三叉神経刺激に伴う血圧変動に関与する中枢経路, 第30回日本歯科麻酔学会総会, 2002年9月.
98.	江口覚, 高石和美, 大下修弘, 野村美幸, 富岡重正, 中條信義 : 歯科局所麻酔時の偶発症と局所麻酔薬アレルギーについての臨床的検討, 第30回日本歯科麻酔学会総会, 2002年9月.
99.	大下修弘, 野村美幸, 高石和美, 江口覚, 富岡重正, 北岡栄一郎, 田野智之, 中條信義 : 大量出血が予想された再生不良性貧血患者の全身麻酔経験, 第17回中国・四国歯科麻酔研究会, 2002年6月.
100.	北岡栄一郎, 田野智之, 野村美幸, 大下修弘, 高石和美, 江口覚, 富岡重正, 中條信義 : 徳島大学歯学部附属病院歯科麻酔科外来に於ける過去10年間の臨床統計学的観察, 第17回中国・四国歯科麻酔研究会, 2002年6月.
101.	野村美幸, 大下修弘, 高石和美, 江口覚, 富岡重正, 北岡栄一郎, 田野智之, 中條信義 : 肝肺症候群患者の抜歯時の全身管理経験, 第17回中国・四国歯科麻酔研究会, 2002年6月.
102.	高石和美, 野村美幸, 大下修弘, 三久富子, 江口覚, 富岡重正, 中條信義 : 遠隔歯科診療支援システムの使用経験, 第29回日本歯科麻酔学会総会, 2001年10月.
103.	三久富子, 野村美幸, 高石和美, 富岡重正, 中條信義, 大下修弘, 江口覚 : 味覚障害患者の治療経験, 第29回日本歯科麻酔学会総会, 2001年10月.
104.	富岡重正, 大下修弘, 野村美幸, 三久富子, 高石和美, 江口覚, 中條信義 : 過換気症候群にプロフォールが無効であった症例, 第29回日本歯科麻酔学会総会, 2001年10月.
105.	高石和美, 小積麻衣子, 和田匡史, 野村美幸, 大下修弘, 三久富子, 江口覚, 富岡重正, 中條信義 : 広範囲顎下部欠損患者の気道確保にCOPAが有用であった一症例, 第16回中国・四国歯科麻酔研究会, 2001年8月.
106.	和田匡史, 小積麻衣子, 野村美幸, 大下修弘, 三久富子, 高石和美, 江口覚, 富岡重正, 中條信義 : マシモセットラディカルの使用経験, 第16回中国・四国歯科麻酔研究会, 2001年8月.
107.	小積麻衣子, 和田匡史, 野村美幸, 大下修弘, 三久富子, 高石和美, 江口覚, 富岡重正, 中條信義 : Sturge-Weber 症候群患者の精神鎮静法経験, 第16回中国・四国歯科麻酔研究会, 2001年8月.
108.	三久富子, 小積麻衣子, 和田匡史, 野村美幸, 大下修弘, 高石和美, 江口覚, 富岡重正, 中條信義 : プロポフォールにより興奮状態を呈した精神鎮静症例, 第16回中国・四国歯科麻酔研究会, 2001年8月.
109.	高石和美, 大下修弘, 三久富子, 江口覚, 富岡重正, 中條信義 : ブラディキニンによる血管内皮細胞内Ca²⁺濃度上昇に対する局所麻酔薬の影響, 第28回日本歯科麻酔学会総会, 2000年10月.
110.	山本真, 山下勉, 新田幸司, 高石和美, 江口覚, 中條信義 : 徳島大学歯学部付属病院における過去10年間の院内救急症例の検討, 第15回中国・四国歯科麻酔研究会, 2000年7月.
111.	三久富子, 新田幸司, 山下勉, 山本真, 高石和美, 江口覚, 中條信義 : 全身麻酔と BIS ( bispectral index ) モニター, 第15回中国・四国歯科麻酔研究会, 2000年7月.
112.	高石和美, 新田幸司, 山下勉, 山本真, 江口覚, 中條信義 : 静脈内鎮静法におけるBISモニターの使用経験, 第15回中国・四国歯科麻酔研究会, 2000年7月.
113.	菊池輝彦, 中久加奈, 藤本尚久, 江口覚, 富岡重正, 中條信義 : 知能機能に対する笑気の影響, 第24回四国歯学会, 2000年6月.

その他・研究会:

1.	西川美佳, 藤原茂樹, 篠島理, 髙田真里菜, 江口覚, 青木理紗, 大塚拓, 斎藤昌司, 吉田雅彦, 高石和美, 川人伸次, 北畑洋 : 成人先天性疾患患者に対する歯科治療時の全身管理2例, 第35回中国・四国歯科麻酔研究会, 2021年8月.
2.	髙田真里菜, 高石和美, 篠島理, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 川人伸次, 北畑洋 : esCCO(非侵襲連続推定心拍出量)測定下にレミマゾラムを使用し全身麻酔を行った高安動脈炎患者の1例, 第35回中国・四国歯科麻酔研究会, 2021年8月.
3.	武川香織, 長岡仁美, 鶴田真生, 真杉幸江, 篠島理, 髙田真里菜, 西川美佳, 青木理紗, 藤原茂樹, 江口覚, 高石和美, 川人伸次, 北畑洋 : 歯科外来におけるRRS(Rapid Response System)へ歯科衛生士が介入した1例, 第35回中国・四国歯科麻酔研究会, 2021年8月.
4.	青木一希, 藤原茂樹, 中尾俊介, 江口覚, 八木香奈枝, 三上可菜子, 立原敬一, 李楊, 大塚良, 江口覚, 高石和美, 大浦邦彦, 敖金平, 北畑洋 : 医療機器への無線電力伝送に使用するオープンリング共振器の設計とシミュレーションについて, 第34 回中国・四国歯科麻酔研究会, 2019年7月.
5.	江口覚, 大塚良, 藤原茂樹, 高石和美, 山本剛士, 大塚拓, 吉田雅彦, 北畑洋 : 注射に対する恐怖心の強い自閉スペクトラム症児の吸入鎮静法管理, 第34 回中国・四国歯科麻酔研究会, 2019年7月.
6.	斎藤英里香, 重光健史, 大塚良, 藤原茂樹, 江口覚, 高石和美, 山本剛士, 大塚拓, 吉田雅彦, 河野文昭, 北畑洋 : 輸血拒否のため術式変更を行った気道確保困難患者の全身麻酔経験, 第34 回中国・四国歯科麻酔研究会, 2019年7月.
7.	藤原茂樹, 敖金平, 大塚良, 山本剛士, 江口覚, 高石和美, 北畑洋 : ワイヤレス給電式医療機器の作成と臨床応用に向けた試み, 第33 回中国・四国歯科麻酔研究会, 2018年9月.
8.	山本剛士, 高石和美, 大塚良, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 高度肥満を有する自閉症スペクトラム障害患者に対して全身麻酔を行った2症例, 第33 回中国・四国歯科麻酔研究会, 2018年9月.
9.	大塚良, 高石和美, 山本剛士, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 巨大甲状腺腫を有する患者の全身麻酔経験, 第33 回中国・四国歯科麻酔研究会, 2018年9月.
10.	大塚良, 高石和美, 新居麻美子, 尾上真奈美, 藤原茂樹, 江口覚, 大塚拓, 吉田雅彦, 北畑洋 : 歯科治療後に悪心嘔吐を認めた患者の精神沈静法経験, 第32回中国·四国歯科麻酔研究会, 2017年7月.
11.	大塚拓, 江口覚, 尾上真奈美, 大塚良, 藤原茂樹, 高石和美, 北畑洋 : 口腔内浸潤麻酔時に麻酔薬の血管内誤注入が疑われた1例, 第32回中国·四国歯科麻酔研究会, 2017年7月.
12.	尾上真奈美, 高石和美, 工藤景子, 髙丸菜都美, 鎌田久美子, 大塚良, 藤原茂樹, 江口覚, 宮本洋二, 北畑洋 : 根管治療後に下歯槽神経感覚障害が生じた1例, 第32回中国·四国歯科麻酔研究会, 2017年7月.
13.	藤原茂樹, 尾上真奈美, 大塚良, 江口覚, 高石和美, 大塚拓, 吉田雅彦, 北畑洋 : OSASを伴った成人Still病患者の歯科治療時の静脈麻酔経験, 第32回中国·四国歯科麻酔研究会, 2017年7月.
14.	江口覚 : 局所麻酔薬アレルギー疑いのある患者への対応, 四国歯学会第42回例会, 2013年3月.
15.	岩田英樹, Haidong Chi, 江口覚, 河野崇 : 術後認知機能障害と疼痛管理影響の関係, 痛みを語る会 in Kochi 2012(第10回整形外科痛みを語る会，第5回麻酔科痛みのメカニズムを語る会), 2012年6月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

歯科治療によるストレス侵襲に対する精神鎮静法の心血管系保護作用 (研究課題/領域番号: 21592576 )
生体吸収性ポリマーを用いた人工血管の開発 (研究課題/領域番号: 16592004 )
静脈内鎮静法が虚血性心疾患発生に及ぼす影響(心筋K-ATPチャネル活性について) (研究課題/領域番号: 14771139 )
鎮静法が味覚刺激に及ぼす影響-苦味刺激を中心にして- (研究課題/領域番号: 10771133 )
侵害刺激による三叉・迷走神経反射は存在するか? (研究課題/領域番号: 10671883 )
笑気吸入後の痛覚過敏反応について--局所脳血流とNO環状GNPの関与 (研究課題/領域番号: 08672313 )
局所麻酔薬の血管への作用について-とくにNO産生への影響- (研究課題/領域番号: 07672179 )
過換気条件における一酸化窒素と脳血流量について (研究課題/領域番号: 06672007 )
研究者番号（20263866）による検索

講師 : 江口覚

研究活動

個人のホームページ

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

総説・解説:

国際会議:

国内講演発表:

その他・研究会:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

講師 : 江口 覚

研究活動

個人のホームページ

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

総説・解説:

国際会議:

国内講演発表:

その他・研究会:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

講師 : 江口覚