Tokushima University / Educator and Researcher Directory --- Tomotake, Yoritoki

Personal Web Page

https://researchmap.jp/read0184036 (researchmap)

Field of Study

○	Dentistry
○	Oral and Maxillofacial Prosthodontics, Oral Implantology

Subject of Study

○
○	Oral Implantology (Dental Implant, Superstructure)

Book / Paper

Book:

1.	Yoritoki Tomotake : よくわかる口腔インプラント学, Ishiyaku Publishers,Inc., 東京, Feb. 2017.
2.	Yoritoki Tomotake, Yuichi Ishida and Tetsuo Ichikawa : インプラントとの隣接面コンタクトは喪失するか?, Dec. 2012.
3.	Yoritoki Tomotake, Yoshihito Naitou and Tetsuo Ichikawa : 力学の基本 -生体に危険な力の理解のために-, Dec. 2012.
4.	Yoritoki Tomotake : よくわかる口腔インプラント学, 医歯薬出版, Jan. 2011.
5.	Tetsuo Ichikawa, Kan Nagao, Yoritoki Tomotake, Yuichi Ishida and 石田修 : リンガライズドオクルージョン -義歯の咬合・インプラントの咬合-(松本直之，市川哲雄監著), Ishiyaku Publishers,Inc., Tokyo, Sep. 2010.
6.	Yoritoki Tomotake and Tetsuo Ichikawa : CT光造形実体モデルとレーザー溶接法を利用した埋入即時負荷インプラント治療, Nov. 2008.
7.	Tetsuo Ichikawa, Yoritoki Tomotake and 井上孝 : 外科即時埋入, Nov. 2008.
8.	Tetsuo Ichikawa, Yoritoki Tomotake and 井上孝 : 外科即時荷重, Nov. 2008.
9.	Yuri Yoshida, Yoritoki Tomotake and Tetsuo Ichikawa : 診断と診断用機器画像診断-コンピュータガイドシステム, Jun. 2008.
10.	Yuri Yoshida, Yoritoki Tomotake and Tetsuo Ichikawa : 診断と診断用機器三次元画像検査用機器, Jun. 2008.
11.	和田匡史, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント補綴インプラントの生物学的幅経, Jun. 2008.
12.	Daisuke Nagao, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント補綴負荷の分類，免荷期間．, Jun. 2008.
13.	Yoshihito Naitou, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント補綴生体適合性/Biocompatibility, Jun. 2008.
14.	Yuichi Ishida, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント補綴インプラントの治療計画, Jun. 2008.
15.	Yoritoki Tomotake and Tetsuo Ichikawa : インプラント補綴インプラントの成功基準, Jun. 2008.
16.	Tetsuo Ichikawa, Yoritoki Tomotake and Hideo Kanitani : 特殊義歯の問題点と対策, Jan. 2006.
17.	Yoritoki Tomotake, Wei Hau, Chen Jianrong and Tetsuo Ichikawa : Implant supporting retaining cases., Oct. 2005.
18.	Yoritoki Tomotake, 渋谷恵子, Daisuke Nagao and Tetsuo Ichikawa : Clinical applications. Tissue supporting and implant retaining cases., Oct. 2005.
19.	Yoritoki Tomotake, Hau Wei, Jianrong Chen and Tetsuo Ichikawa : インプラント支持，インプラント維持の症例, Oct. 2005.
20.	Yoritoki Tomotake, 渋谷恵子, Daisuke Nagao and Tetsuo Ichikawa : 臨床への応用粘膜支持，インプラント維持の症例, Oct. 2005.
21.	Yoritoki Tomotake, Hideo Kanitani, Fumiaki Kawano and Tetsuo Ichikawa : ステリオスインプラント, Jan. 2000.

Academic Paper (Judged Full Paper):

1.	Yasufumi Nishikawa, Yoritoki Tomotake, Hiromichi Kawano, Koji Naruishi, Jun-ichi Kido, Yuka Hiroshima, Akikazu Murakami, Tetsuo Ichikawa and Hiromichi Yumoto : Effects of Candidalysin Derived from Candida albicans on the Expression of Pro-Inflammatory Mediators in Human Gingival Fibroblasts, International Journal of Molecular Sciences, Vol.24, No.4, 3256, 2023. (Tokushima University Institutional Repository) ● Metadata: 118834 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms24043256 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36834667 ● Search Scopus @ Elsevier (PMID): 36834667 ● Search Scopus @ Elsevier (DOI): 10.3390/ijms24043256 (Tokushima University Institutional Repository: 118834, DOI: 10.3390/ijms24043256, PubMed: 36834667)
2.	Rie Kido, Jun-ichi Kido, Yasufumi Nishikawa, Eijiro Sakamoto, Yoritoki Tomotake and Hiromichi Yumoto : Diagnosis of inflammatory peri-implant diseases using an immunochromatographic assay for calprotectin in peri-implant crevicular fluid, International Journal of Implant Dentistry, Vol.7, No.1, 106, 2021. (Summary) The incidence rate of peri-implant diseases is increasing with implant placement. Early detection of peri-implant diseases is important to prevent and treat these diseases, and a simple and objective diagnostic method is expected. Immunochromatographic (IC) assays are used for rapid diagnostic methods for some diseases. The aim of this clinical study was to determine the amount of calprotectin, an inflammatory marker, in peri-implant crevicular fluid (PICF) using an IC chip, and estimate the possibility of this diagnostic system. Forty-six individuals with dental implants participated in a pilot study. PICF samples were collected from the peri-implant sites with or without inflammation after clinical examinations including probing depth (PD), bleeding on probing (BOP) and gingival index (GI). Calprotectin in PICF was determined by an IC chip and enzyme-linked immunosorbent assay (ELISA) for calprotectin. The density of calprotectin line on the IC chip was measured using an IC reader (IC reader value). The relationship between IC reader value and ELISA value or clinical parameters was investigated. A receiver operating characteristic (ROC) curve analysis of IC reader value of calprotectin was performed to predict inflammation in peri-implant diseases. IC reader value of calprotectin was significantly correlated with its ELISA value and PD. IC reader values of calprotectin in PICF samples from periodontal sites with GI-1 and GI-2, and with BOP-positive sites were significantly higher than those of PICF samples from GI-0 sites, and BOP-negative sites, respectively. The IC reader value for calprotectin in PICF samples from inflammatory diseased sites was significantly higher than that of non-diseased sites. ROC analysis suggested that the IC reader value of PICF calprotectin was useful for predicting inflammatory peri-implant diseases. IC assay for PICF calprotectin may be a possible system for diagnosing the inflammatory peri-implant diseases. (Keyword) Calprotectin / Diagnosis / Immunochromatographic assay / Peri-implant diseases / Peri-implant crevicular fluid (Link to Publication Site) ● Publication site (DOI): 10.1186/s40729-021-00386-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34623545 ● Search Scopus @ Elsevier (PMID): 34623545 ● Search Scopus @ Elsevier (DOI): 10.1186/s40729-021-00386-z (DOI: 10.1186/s40729-021-00386-z, PubMed: 34623545)
3.	Yoritoki Tomotake, Hiromichi Kawano, Yasufumi Nishikawa, Kaori TAKEKAWA, Masaru TOMINAGA and Tetsuo Ichikawa : Clinical Statistical Study of New Patients in Oral Implant Center at Tokushima University Hospital, Journal of Oral Health and Biosciences, Vol.33, No.2, 39-44, 2021. (Summary) <b>Purpose:</b> Oral Implant Center established in April 2014 as specialized clinical section at Tokushima University Hospital. The aim of this study was to report a survey of new patients of preoperative registration at Oral Implant Center during the five years since its establishment.<br> <b>Subjects and methods:</b> Investigation of gender and age, chief complaint, details of treatment requests, sites of missing teeth, number of missing teeth, cause of tooth extraction, and treatment status for patients registered at Oral Implant Center from April 2014 to March 2019 were performed.<br> <b>Results:</b> Regarding the chief complaint, 605 (88.3%) patients consulted preoperatively for a request for implant treatment, and 80 (11.7%) consulted about complain of previous implant treatment or a request for continued maintenance. The average number of missing teeth for which treatment was requested was 3.8. The proportion of patients who wished to be treated for the number of missing teeth was 32.2% for missing one tooth, 56.1% for missing few teeth (2 to 6 teeth), 7.8% for missing many teeth (7 or more teeth) and edentulous 3.9%. As for the details of treatment requests of 80 patients who had already received implant treatment, 33 (41.3%) consulted on the improper superstructure, 29 (36.3%) wished to examine and treat peri-implantitis, 4 (5%) wished to remove the implant and 14 (17.5%) requested continued maintenance.<br> <b>Discussion and conclusion:</b> The number of new patients regarding implant treatment has been about the same each year, and it was reconfirmed that it was recognized as a treatment method for dental prostheses. In particular, many patients wished to receive implant treatment for a single tooth missing, suggesting that the patients also recognized the importance of preserving the remaining teeth. On the other hand, the number of patients complaining of previous implant treatment tends to increase, and it is necessary to consider future correspondence. (Keyword) Oral Implant Center / implant treatment / preoperative registration (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.33.2_39 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1391975831240588672 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.33.2_39 (DOI: 10.20738/johb.33.2_39, CiNii: 1391975831240588672)
4.	Takaharu Goto, Nobuaki Higaki, Takahiro Kishimoto, Yoritoki Tomotake and Tetsuo Ichikawa : Does periodontal tactile input uniquely increase cerebral blood flow in the prefrontal cortex?, Brain Sciences, Vol.10, No.8, E482, 2020. (Summary) We previously studied the effect of peripheral sensory information from sensory periodontal ligament receptors on prefrontal cortex (PFC) activity. In the dental field, an alternative dental implant without periodontal sensation can be applied for missing teeth. In this study, we examine whether periodontal tactile input could increase cerebral blood flow (CBF) in the PFC against elderly patients with dental implants lacking periodontal tactile (implant group), elderly individuals with natural teeth (elderly group), and young individuals with natural teeth (young group). The experimental task of maintaining occlusal force as closed-loop stimulation was performed. Compared with the young group, the elderly group showed significantly lower CBF. Contrastingly, compared with the young group, the implant group showed significantly lower CBF. There were no significant differences between the elderly and implant groups. Regarding the mean occlusal force value, compared with the young group and the elderly group, the implant group had a numerically, but not significantly, larger occlusal force exceeding the directed range. In conclusion, the periodontal tactile input does not uniquely increase PFC activity. However, increased CBF in the PFC due to the periodontal tactile input in the posterior region requires existing attention behavior function in the PFC. (Tokushima University Institutional Repository) ● Metadata: 115883 (Link to Publication Site) ● Publication site (DOI): 10.3390/brainsci10080482 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32722618 ● Search Scopus @ Elsevier (PMID): 32722618 ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10080482 (Tokushima University Institutional Repository: 115883, DOI: 10.3390/brainsci10080482, PubMed: 32722618)
5.	Yoritoki Tomotake, Takaharu Goto, 石田雄一, 内藤禎人, 荒井安希, 清野方子, 渡邉恵 and Tetsuo Ichikawa : 歯磨剤に配合された顆粒成分のインプラント周囲溝への侵入性の調査, Journal of Japanese Society of Oral Implantology, Vol.31, No.4, 309-319, 2018. (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.31.309 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390564238077382016 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.31.309 (DOI: 10.11237/jsoi.31.309, CiNii: 1390564238077382016)
6.	Eijiro Sakamoto, Rie Kido, Yoritoki Tomotake, Yoshihito Naitou, Yuichi Ishida and Jun-ichi Kido : Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study, International Journal of Implant Dentistry, Vol.4, No.1, 26, 2018. (Summary) Peri-implant crevicular fluid (PICF) contains calprotectin and NTx, which are markers for inflammation and bone resorption, respectively. The aims of this pilot study were to compare calprotectin and NTx levels in PICF from implant sites with or without peri-implant diseases and to evaluate the usefulness of calprotectin and NTx as diagnostic markers for peri-implant diseases. Thirty-five patients with dental implants participated in this pilot study. PICF samples were collected from peri-implant disease sites (n = 40) and non-diseased (healthy) sites (n = 34) after clinical indicators including probing depth (PD), bleeding on probing (BOP), gingival index (GI), and bone loss (BL) rate were investigated. Calprotectin and NTx amounts in PICF were measured using their respective ELISA kits and then compared between diseased and healthy samples. The relationship between PICF calprotectin or NTx levels and clinical indicator levels was investigated. A receiver operating characteristic (ROC) curve analysis of calprotectin and NTx was performed to predict peri-implant diseases. Calprotectin and NTx levels in PICF were significantly higher from peri-implant disease sites than from healthy sites. PICF calprotectin amounts correlated with PD, and its levels were significantly higher in the GI-1 and GI-2 groups than in the GI-0 group. PICF NTx amounts correlated with PD and the BL rate. ROC curves indicated that PICF calprotectin and NTx are useful biomarkers for peri-implant diseases. Calprotectin and NTx in PICF have potential as biomarkers for the diagnosis of peri-implant diseases. (Tokushima University Institutional Repository) ● Metadata: 113981 (Link to Publication Site) ● Publication site (DOI): 10.1186/s40729-018-0138-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30209708 ● Search Scopus @ Elsevier (PMID): 30209708 ● Search Scopus @ Elsevier (DOI): 10.1186/s40729-018-0138-2 (Tokushima University Institutional Repository: 113981, DOI: 10.1186/s40729-018-0138-2, PubMed: 30209708)
7.	Yoshihito Naitou, Hiromichi Yumoto, K Hs Kumar, Takashi Matsuo, Katsuhiko Hirota, Yoichiro Miyake, Kan Nagao, Yoritoki Tomotake, R Jimbo and Tetsuo Ichikawa : Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component, --- An In Vitro Study ---, Journal of Prosthodontics, Vol.27, No.7, 665-669, 2018. (Summary) To evaluate the antifungal activity and mechanical properties of a novel antifungal tissue conditioner containing Juncus powder. Juncus powder was mixed with GC tissue conditioner at concentrations of 2.5%, 5.0%, and 10.0% by mass. The cylindrical specimens of Juncus-mixed tissue conditioner (dimensions: 10 mm in diameter and 2 and 6 mm in height for antimicrobial and mechanical tests, respectively) were prepared. The specimens placed on the bottom of the 24-well tissue culture plate were cultured with Candida albicans CAD1 for 2 and 4 days. The proliferation of the C. albicans in the wells was determined by measuring the optical density of fungal culture, and the surface of the specimens were also observed by scanning electron microscopy (SEM). To assess the mechanical properties of the specimens, the fluidity and hardness of Juncus-mixed tissue conditioner were measured using the methods certified according to ISO 10139-1. Juncus-mixed tissue conditioner significantly exhibited growth inhibitory effect in a Juncus concentration-dependent manner after both 2- and 4- day cultures. SEM observation showed that the amount of C. albicans on Juncus-mixed specimens drastically decreased, and biofilm formation was markedly inhibited. Moreover, both mechanical properties were found to be within the ranges regulated and specified by ISO. These findings demonstrated that the tissue conditioner including Juncus powder has a significant growth inhibitory effect against C. albicans, and it is suggested that the application of Juncus-mixed tissue conditioner may prevent denture stomatitis and oral candidiasis in denture wearers. (Link to Publication Site) ● Publication site (DOI): 10.1111/jopr.12546 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28901663 ● Search Scopus @ Elsevier (PMID): 28901663 ● Search Scopus @ Elsevier (DOI): 10.1111/jopr.12546 (DOI: 10.1111/jopr.12546, PubMed: 28901663)
8.	Gantumur Chimeddulam, Keisuke Nishigawa, Yoshihito Naitou, Junhel Dalanon, S Afroz, Rika Hayama, Masamitsu Ohshima, Yoritoki Tomotake, Tetsuo Ichikawa and Yoshizo Matsuka : Radiographic investigation of the marginal bone loss on dental implants, a retrospective cohort study, Journal of Oral Health and Biosciences, Vol.31, No.1, 13-24, 2018. (Summary) <b>Background:</b> During functional loading, the design of the dental implant may have an effect on the response of marginal bone.<br><b>Objectives:</b> The purpose of this study was to report the prevalence of peri-implantitis, and to compare radiographic parameters around Brånemark and Replace Select dental implants and evaluate whether disparities in the morphologic features of these two indistinct implant systems, particularly their abutment-implant attachment, had an influence on the health of surrounding tissues and marginal bone loss (MBL).<br><b>Materials and Methods:</b> Collection of data was done at the Department of Fixed Prosthodontics, the Department of Maxillo-Facial Prosthodontics, and Oral Implant Center of Tokushima University Hospital, in Tokushima, Japan; between March 2003 and followed until January 2017. Patients who have been treated with the Replace Select internal type implant and the Brånemark variety were selected as cohort. Marginal bone level measurements were evaluated via periapical and panoramic radiographs taken at regular follow-up visit. These dimensions were calculated, starting from the orientation mark at the implant abutment interface to the bottommost perceived contact area of marginal bone with the aforementioned implant system. The change in the level of bone was estimated by calculating the variation involving an initial reference value and the follow-up values.<br><b>Results:</b> An average loss of bone at 0.65 ± 1.51 mm (range 0.36 to 7.89 mm) in the Replace Select group was observed, while in the Brånemark group 0.7 ± 1.32 mm (range 0.62 to 8.64 mm) was observed. Spearman rank correlation exhibited a statistically significant positive correlation between progress of bone loss around implant body and interval from implantation in the Brånemark group, whereas in the Replace Select group it was not significant. The Brånemark group exhibited significant (P = 0.0269) negative correlation of MBL and its diameters, whereas the Replace Select group did not exhibit such correlation.<br><b>Conclusion:</b> Within the limits of this study, it can be concluded that deviations in the morphologic attributes of these two diverse implant systems had an influence on the health of surrounding tissues and MBL. The Brånemark implants showed a significant increase in MBL (> 1.8mm) as the time of placement elapses. This marked MBL was greater in females than males, in posterior than in anterior, and in the narrow platform implants than the regular platform implants or the wide platform implants. On the other hand, results suggested that this bone loss was greater in the mandible than the maxilla, in single-unit implant crowns than multiple implant restorations in the Replace Select group. (Keyword) dental implant / marginal bone loss / retrospective cohort study / implant design (Tokushima University Institutional Repository) ● Metadata: 111932 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.31.1_13 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282763020251776 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_13 (Tokushima University Institutional Repository: 111932, DOI: 10.20738/johb.31.1_13, CiNii: 1390282763020251776)
9.	Tetsuo Ichikawa, Yoritoki Tomotake, Toyoko Tajima, Yoshihito Naitou, Yuji Shimizu and Yuichi Ishida : Glass-fiber Reinforced 3-unit Metal-less Bridge: Short-term Preliminary Results, Journal of Oral Health and Biosciences, Vol.28, No.2, 55-62, 2016. (Summary) Mechanical strength to withstand occlusal force is required to the crown restorations of molars. Ag-Pd-Au alloy has been used as the acceptable material of the National Health Insurance system in Japan. However, the metallic color of prosthesis does not meet the aesthetic requirements of the patients, and there is also a problem to the provider side of the treatment that the price fluctuation is large by soaring material costs. A fiber reinforced metal-less bridge is proposed to resolve these problems and we began clinical application of this prosthetic treatment from September, 2012 on the approval of Tokushima University Hospital ethics committee. So far, six patients have been treated with 8 fiber reinforced bridges, and this treatment in Tokushima University Hospital was approved in Shikoku Regional Bureau of Health and Welfare as the advanced medical. We have followed the treatment for a maximum of more than two years, and it has been passed successfully with patient's satisfaction. Slightly problems which were caused in the hybrid resin material, could be easily solved by the direct procedures. This clinical results in short term suggested that the fiber reinforced metalless bridge have a sufficiently high therapeutic effect as a prosthetic method. (Keyword) 高強度コンポジットレジンブリッジ / グラスファイバー補強 / 金属代替材料 (Tokushima University Institutional Repository) ● Metadata: 109869 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050020697877560832 (Tokushima University Institutional Repository: 109869, CiNii: 1050020697877560832)
10.	Takashi Matsuda, Takaharu Goto, Kosuke Kurahashi, Toshiya Kashiwabara, Megumi Watanabe, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : Digital assessment of preliminary impression accuracy for edentulous jaws: Comparisons of 3-dimensional surfaces between study and working casts, Journal of Prosthodontic Research, Vol.60, No.3, 206-212, 2016. (Summary) The aim of this study was to compare 3-dimensional surfaces of study and working casts for edentulous jaws and to evaluate the accuracy of preliminary impressions with a view to the future application of digital dentistry for edentulous jaws. Forty edentulous volunteers were serially recruited. Nine dentists took preliminary and final impressions in a routine clinical work-up. The study and working casts were digitized using a dental 3-dimensional scanner. The two surface images were superimposed through a least-square algorithm using imaging software and compared qualitatively. Furthermore, the surface of each jaw was divided into 6 sections, and the difference between the 2 images was quantitatively evaluated. Overall inspection showed that the difference around residual ridges was small and that around borders were large. The mean differences in the upper and lower jaws were 0.26mm and 0.45mm, respectively. The maximum values of the differences showed that the upward change mainly occurred in the anterior residual ridge, and the downward change mainly in the posterior border seal, and the labial and buccal vestibules, whereas every border of final impression was shortened in the lower jaw. The accuracy in all areas except the border, which forms the foundation, was estimated to be less than 0.25mm. Using digital technology, we here showed the overall and sectional accuracy of the preliminary impression for edentulous jaws. In our clinic, preliminary impressions have been made using an alginate material while ensuring that the requisite impression area was covered. (Tokushima University Institutional Repository) ● Metadata: 109708 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jpor.2015.12.007 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26822762 ● Summary page in Scopus @ Elsevier: 2-s2.0-84957824113 (Tokushima University Institutional Repository: 109708, DOI: 10.1016/j.jpor.2015.12.007, PubMed: 26822762, Elsevier: Scopus)
11.	近藤尚知, 尾澤昌悟, 澤瀬隆, 横山敦郎, 関根秀志, 舞田健夫, 鮎川保則, 中野環, 久保隆靖, 細川隆司, Yoritoki Tomotake, 城戸寛史, 越智守生, 塩田真, 尾関雅彦, 西村正宏, 前田芳信, 會田英紀, 玉置勝司, 笛木賢治, 塚崎弘明, 小野高裕, 松下恭之, Yoshizo Matsuka, 水口一, 桑鶴利香, 山下秀一郎, 飯塚知明, 馬場一美, 藤澤政紀, 古谷野潔 and 矢谷博文 : "Occlusal consideration for fixed implant prosthesis in mandibular posterior region", Annals of Japan Prosthodontic Society, Vol.8, No.1, 1-9, 2016. (Summary) Clinical guidelines or definitive criteria for "Occlusal consideration for fixed implant prosthesis in mandibular posterior region" have not been established yet although the dental implant is an essential treatment option for current prosthetic dentistry. This position paper aimed to propose a critical recommendation and consequently indicate a tentative practice guideline. In this paper, the first and second molar missing in the mandible was assumed as the most typical partial edentulous jaw. A panel of clinical experts concerning dental implant practice was selected from the members of the Japan Prosthodontic Society, and a meeting was held to collect clinical data obtained from daily practice and to estimate expert opinions. As a result, general remarks were presented regarding shapes of prostheses, position and number of occlusal contact points, occlusal contact during lateral excursion, displacement of periodontal ligament, and materials of occlusal surface. However, the expert opinions described above have not been supported by clinical evidence. Moreover, neither the effect of those therapies nor long-term prognosis has been thoroughly investigated. Thus, further study for collecting the clinical evidences is required to formulate the clinical guideline. (Keyword) Implants / Fixed prosthesis / Occlusion / Shape of crown / Periodontal ligament (Link to Publication Site) ● Publication site (DOI): 10.2186/ajps.8.1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205301164032 ● Search Scopus @ Elsevier (DOI): 10.2186/ajps.8.1 (DOI: 10.2186/ajps.8.1, CiNii: 1390001205301164032)
12.	Yoshihito Naitou and Yoritoki Tomotake : 任意形状の付与が可能なチタン多孔体の生体材料への応用研究．内藤禎人，友竹偉則．チタン 63(4)52-57 2015．, チタン, Vol.63, No.4, 52-57, 2015.
13.	Yuki Iwawaki, Noriko Mizusawa, Takeo Iwata, Nobuaki Higaki, Takaharu Goto, Megumi Watanabe, Yoritoki Tomotake, Tetsuo Ichikawa and Katsuhiko Yoshimoto : MiR-494-3p induced by compressive force inhibits cell proliferation in MC3T3-E1 cells., Journal of Bioscience and Bioengineering, Vol.120, No.4, 456-462, 2015. (Summary) Mechanical stimuli regulate fundamental cell processes such as proliferation, differentiation, and morphogenesis. We attempted to identify microRNA (miRNA) whose expression is changed during compressive treatment in MC3T3-E1, a pre-osteoblastic cell line. Microarray analysis followed by reverse transcription-quantitative polymerase chain reaction revealed that compressive force at 294 Pa for 24 h in MC3T3-E1 cells increased levels of miR-494-3p, miR-146a-5p, miR-210-3p, and miR-1247-3p. Among these miRNAs, miR-494-3p was found to inhibit cell proliferation in MC3T3-E1 cells. Furthermore, cells subjected to compressive force showed slower cell growth compared with control cells. Levels of mRNA for fibroblast growth factor receptor 2 (FGFR2) and Rho-associated coiled-coil kinase 1 (ROCK1), which were predicted to be targets of miR-494-3p, were decreased by compressive force or overexpression of miR-494-3p mimics in MC3T3-E1 cells. Furthermore, binding sites of miR-494-3p within 3'-untranslated regions of Fgfr2 and Rock1 were determined using luciferase reporter assay. In conclusion, compressive force affected expressions of several miRNAs including miR-494-3p in MC3T3-E1 cells. Compressive force might inhibit cell proliferation in osteoblasts by up-regulating miR-494-3p followed by FGFR2 and ROCK1 gene repressions. (Keyword) 3' Untranslated Regions / Cell Line / Cell Proliferation / Down-Regulation / Gene Expression Regulation / Humans / Luciferases / MicroRNAs / Oligonucleotide Array Sequence Analysis / Osteoblasts / RNA, Messenger / Receptor, Fibroblast Growth Factor, Type 2 / Reverse Transcriptase Polymerase Chain Reaction / Stress, Mechanical / Up-Regulation / rho-Associated Kinases (Tokushima University Institutional Repository) ● Metadata: 109479 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jbiosc.2015.02.006 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25795570 ● Summary page in Scopus @ Elsevier: 2-s2.0-84938332268 (Tokushima University Institutional Repository: 109479, DOI: 10.1016/j.jbiosc.2015.02.006, PubMed: 25795570, Elsevier: Scopus)
14.	Prananingrum Widyasri, Yoshihito Naitou, Yoritoki Tomotake, Toyoko Tajima and Tetsuo Ichikawa : モールドレスプロセスによるチタン多孔体のインプラント上部構造への応用, Journal of Japanese Society of Oral Implantology, Vol.28, 305, 2015.
15.	Yoritoki Tomotake, Yuki Iwawaki, Takaharu Goto, 西中英伸 and Tetsuo Ichikawa : インプラント上部構造における前装材破折と主機能部位との関連について, Journal of Japanese Society of Oral Implantology, Vol.28, No.3, 326-333, 2015. (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.28.326 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205510925824 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.28.326 (DOI: 10.11237/jsoi.28.326, CiNii: 1390001205510925824)
16.	Takaharu Goto, Kan Nagao, Yuichi Ishida, Yoritoki Tomotake and Tetsuo Ichikawa : Influence of female attachment installation load on movement and resultant forces in implant overdentures, Journal of Prosthodontics, Vol.24, No.2, 156-163, 2015. (Summary) This in vitro study investigated the effect of attachment installation conditions on the load transfer and denture movements of implant overdentures, and aims to clarify the differences among the three types of attachments, namely ball, Locator, and magnet attachments. Three types of attachments, namely ball, Locator, and magnetic attachments were used. An acrylic resin mandibular edentulous model with two implants placed in the bilateral canine regions and removable overdenture were prepared. The two implants and bilateral molar ridges were connected to three-axis load-cell transducers, and a universal testing machine was used to apply a 50 N vertical force to each site of the occlusal table in the first molar region. The denture movement was measured using a G(2) motion sensor. Three installation conditions, namely, the application of 0, 50, and 100 N loads were used to install each attachment on the denture base. The load transfer and denture movement were then evaluated. The resultant force decreased with increasing installation load for all attachments. In particular, the resultant force on implants on the loading side of the Locator attachment significantly decreased when the installation load was increased from 0 to 50 N, and that for magnetic attachment significantly decreased when the installation load was increased from 50 to 100 N. For the residual ridges on the loading side, the direction of the forces for all attachments changed to downward with increasing installation load. Furthermore, the yaw Euler angle increased with increasing installation load for the magnetic attachment. Subject to the limitations of this study, the use of any installation load greater than 0 N is recommended for the installation of ball and Locator attachments on a denture base. Regarding magnetic attachments, our results also recommend installation on a denture base using any installation load greater than 0 N, and suggest that the resultant force acting on the implant can be decreased by increasing the installation load; however, a large installation load of 100 N should be avoided when installing the attachment on the denture base to avoid increasing the denture movement. (Link to Publication Site) ● Publication site (DOI): 10.1111/jopr.12177 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24975368 ● Summary page in Scopus @ Elsevier: 2-s2.0-84923081891 (DOI: 10.1111/jopr.12177, PubMed: 24975368, Elsevier: Scopus)
17.	Takanori Kawano, Widyasri Prananingrum, Yuichi Ishida, Takaharu Goto, Yoshihito Naitou, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : Blue-violet laser modification of titania treated titanium: antibacterial and osteo-inductive effects, PLoS ONE, Vol.8, No.12, e84327, 2013. (Summary) Many studies on surface modifications of titanium have been performed in an attempt to accelerate osseointegration. Recently, anatase titanium dioxide has been found to act as a photocatalyst that expresses antibiotic properties and exhibits hydrophilicity after ultraviolet exposure. A blue-violet semiconductor laser (BV-LD) has been developed as near-ultraviolet light. The purpose of this study was to investigate the effects of exposure to this BV-LD on surface modifications of titanium with the goal of enhancing osteoconductive and antibacterial properties. The surfaces of pure commercial titanium were polished with #800 waterproof polishing papers and were treated with anatase titania solution. Specimens were exposed using BV-LD (λ = 405 nm) or an ultraviolet light-emitting diode (UV-LED, λ = 365 nm) at 6 mW/cm(2) for 3 h. The surface modification was evaluated physically and biologically using the following parameters or tests: surface roughness, surface temperature during exposure, X-ray diffraction (XRD) analysis, contact angle, methylene blue degradation tests, adherence of Porphyromonas gingivalis, osteoblast and fibroblast proliferation, and histological examination after implantation in rats. No significant changes were found in the surface roughness or XRD profiles after exposure. BV-LD exposure did not raise the surface temperature of titanium. The contact angle was significantly decreased, and methylene blue was significantly degraded. The number of attached P. gingivalis organisms was significantly reduced after BV-LD exposure compared to that in the no exposure group. New bone was observed around exposed specimens in the histological evaluation, and both the bone-to-specimen contact ratio and the new bone area increased significantly in exposed groups. This study suggested that exposure of titanium to BV-LD can enhance the osteoconductivity of the titanium surface and induce antibacterial properties, similar to the properties observed following exposure to UV-LED. (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0084327 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24358355 ● Summary page in Scopus @ Elsevier: 2-s2.0-84892924993 (DOI: 10.1371/journal.pone.0084327, PubMed: 24358355, Elsevier: Scopus)
18.	Tetsuo Ichikawa, Takaharu Goto and Yoritoki Tomotake : Stress Analysis of Magnet-Retained Mini-Implant Overdenture:InVitro Study, Journal of Japanese Society of Oral Implantology, Vol.26, No.4, 660-667, 2013. (Summary) The purpose of this study was to evaluate stress analysis of a magnet-retained mini-implant overdenture on an in vitro mandibular model. Mini implants less than 3.0 mm in diameter have been used as not only provisional use, but also permanent use to support overdentures.<br/>Four mini implants (MagDen Fixture MFI4010RF, Shinwon Dental, Seoul, Korea) were placed in edentulous regions between bilateral canines in an acrylic resin mandibular model and the abutments (MagDen Keeper MFK4020, Shinwon Dental, Seoul, Korea) for magnet attachments were used. Seven strain gauges were attached on the resin surface around the right side of two mini implants. The surface of the model was covered with silicone impression material to simulate oral mucosa and an experimental complete denture was placed on the model. A vertical force of 50 N was applied to either one of the premolar, first molar and second molar of the experimental denture using a universal testing machine. <br/>When four mini implants were supported, compressive strains were caused at the lingual side of the distal mini implant. The more posterior the loading point was, the lower the strain around the implant was generally. Although tensile strain was caused at the buccal side of the mesial mini implant, it decreased at the moment when compressive strain arose. When four implants were supported, the strain around the mini implants was distributed more evenly than those in the two implant-supported ones. The influence of implant positioning was examined by removing either two mesial or two distal attachments in the four mini implants. The maximum strain in two mesial implant-supported attachments was smaller than that in two distal implant-supported attachments. (Keyword) mini implant / stress analysis / magnetic attachment / overdenture / strain (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.26.660 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680483292160 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.26.660 (DOI: 10.11237/jsoi.26.660, CiNii: 1390282680483292160)
19.	Hideki Suito, Yuki Iwawaki, Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : Oral factors affecting titanium elution and corrosion: an in vitro study using simulated body fluid., PLoS ONE, Vol.8, No.6, e66052, 2013. (Summary) Ti, which is biocompatible and resistant to corrosion, is widely used for dental implants, particularly in patients allergic to other materials. However, numerous studies have reported on Ti allergy and the in vitro corrosion of Ti. This study investigated the conditions that promote the elution of Ti ions from Ti implants. Specimens of commercially pure Ti, pure nickel, a magnetic alloy, and a gold alloy were tested. Each specimen was immersed in a simulated body fluid (SBF) whose pH value was controlled (2.0, 3.0, 5.0, 7.4, and 9.0) using either hydrochloric or lactic acid. The parameters investigated were the following: duration of immersion, pH of the SBF, contact with a dissimilar metal, and mechanical stimulus. The amounts of Ti ions eluted were measured using a polarized Zeeman atomic absorption spectrophotometer. Eluted Ti ions were detected after 24 h (pH of 2.0 and 3.0) and after 48 h (pH of 9.0). However, even after 4 weeks, eluted Ti ions were not detected in SBF solutions with pH values of 5.0 and 7.4. Ti elution was affected by immersion time, pH, acid type, mechanical stimulus, and contact with a dissimilar metal. Elution of Ti ions in a Candida albicans culture medium was observed after 72 h. Elution of Ti ions in the SBF was influenced by its pH and by crevice corrosion. The results of this study elucidate the conditions that lead to the elution of Ti ions in humans, which results in implant corrosion and Ti allergy. (Keyword) Body Fluids / Candida albicans / Corrosion / Dental Alloys / Humans / Hydrogen-Ion Concentration / Ions / Solutions / Stress, Mechanical / titanium (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0066052 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23762461 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878805527 (DOI: 10.1371/journal.pone.0066052, PubMed: 23762461, Elsevier: Scopus)
20.	Tetsuo Ichikawa, Yoritoki Tomotake and Takaharu Goto : A Literature Review on the Perception of Implants : Comparison with Natural Teeth, Journal of Japanese Society of Oral Implantology, Vol.26, No.2, 272-280, 2013. (Keyword) perception / dental implants / sensation (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205505687168 (CiNii: 1390001205505687168)
21.	Yoshihito Naitou, Jiyon Be, Yoritoki Tomotake, Kenichi Hamada, Kenzo Asaoka and Tetsuo Ichikawa : Formability and mechanical properties of porous titanium produced by a moldless process, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.101, No.6, 1090-1094, 2013. (Summary) Tailor-made porous titanium implants show great promise in both orthopedic and dental applications. However, traditional powder metallurgical processes require a high-cost mold, making them economically unviable for producing unique devices. In this study, a mixture of titanium powder and an inlay wax binder was developed for moldless forming and sintering. The formability of the mixture, the dimensional changes after sintering, and the physical and mechanical properties of the sintered porous titanium were evaluated. A 90:10 wt % mixture of Ti powder and wax binder was created manually at 70°C. After debindering, the specimen was sintered in Ar at 1100°C without any mold for 1, 5, and 10 h. The shrinkage, porosity, absorption ratio, bending and compressive strength, and elastic modulus were measured. The bending strength (135-356 MPa), compression strength (178-1226 MPa), and elastic modulus (24-54 GPa) increased with sintering time; the shrinkage also increased, whereas the porosity (from 37.1 to 29.7%) and absorption ratio decreased. The high formability of the binder/metal powder mixture presents a clear advantage for fabricating tailor-made bone and hard tissue substitution units. Moreover, the sintered compacts showed high strength and an elastic modulus comparable to that of cortical bone. (Keyword) Biocompatible Materials / Compressive Strength / Dental Implants / Elastic Modulus / Humans / Materials Testing / Metallurgy / Porosity / Prostheses and Implants / titanium (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.b.32919 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23559484 ● Summary page in Scopus @ Elsevier: 2-s2.0-84880509056 (DOI: 10.1002/jbm.b.32919, PubMed: 23559484, Elsevier: Scopus)
22.	Hideki Suito, Takaharu Goto, 岩脇有軌, Yoritoki Tomotake and Tetsuo Ichikawa : 磁性アッタチメントを用いたミニインプラントオーバーデンチャーの力学的解析, Journal of Japanese Society of Oral Implantology, Vol.26, No.4, 660-667, 2013.
23.	Hideki Suito, Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : 固定方法からみたインプラント上部構造の臨床的・文献的考察, Shikoku Dental Research, Vol.25, No.2, 39-46, 2013. (Summary) As the connection mechanism between the superstructure and implant, the cement-retained type and screw-retained type are mainly used. The choice of a screw-retained versus a cement-retained superstructure is a complex and comprehensive decision involving many points of consideration. On the other hand, various retained methods that is complementary with each retained type have been proposed. In this article, various retained types which have been reported in the literatures and developed by us, were systematically assorted from the standpoints of retreivability, and the advantages were pointed out showing case photographs. This systematical information would help the selection of retained type of the superstructure. (Keyword) 上部構造 / 固定方法 / 固定性 / 可撤性 / 系統的分類 (Tokushima University Institutional Repository) ● Metadata: 109827 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050020697877581056 (Tokushima University Institutional Repository: 109827, CiNii: 1050020697877581056)
24.	Chen Rong Jian, Yoritoki Tomotake, Megumi Watanabe, Yuichi Ishida, Kan Nagao and Tetsuo Ichikawa : Telescopic Magnetic Attachment for Implant-Supported Denture: Evaluation of Splint Effect, The International Journal of Oral & Maxillofacial Implants, Vol.26, No.3, 657-664, 2011. (Summary) Retrievability, connecting strength, and ease of laboratory work are important but conflicting prerequisites for the success of an implant superstructure, particularly with regard to immediate function. To resolve this issue, a telescopic magnetic attachment system has been developed for implant-supported removable dentures. The splinting effect of the attachment was evaluated for stress distribution and elevation with an in vitro model of three implants in an edentulous mandible. Two types of telescopic magnetic attachments were prepared; the inclination angles of the axial wall of the abutment were 2.5 and 6.0 degrees. Three types of three-unit superstructures--a screw-retained superstructure and two telescopic magnet-retained superstructures--were fabricated. Static loads of 24.5, 49, and 98 N were applied vertically at three loading points on one side of each occlusal table. The elevation was measured as the height at which the magnet-retained superstructure detached from the abutment (on the other side of the prosthesis). In addition, by means of strain gauges, the stress distribution around the implants was evaluated and compared among the superstructures with the same three loads applied at six different points. The magnet-retained superstructure with the axial wall inclined at 2.5 degrees did not detach from the abutment. The differences in stress distribution between the screw-retained and magnet-retained superstructures with a 2.5-degree inclination were found to be statistically insignificant. The magnet-retained superstructure with a 6-degree inclination detached from the abutment, and the stress was concentrated during loading to a cantilever site. Because of its stress distribution and elevation, the new telescopic magnetic attachment, which has properties such as splinting the implants, ease of fabrication, and retrievability, is expected to be a viable alternative for the retention of implant-supported removable dentures. (Keyword) Dental Abutments / Dental Clasps / Dental Implantation, Endosseous / Dental Implants / Dental Models / Dental Prosthesis Design / Dental Prosthesis, Implant-Supported / Dental Stress Analysis / Denture Retention / Humans / Magnetics / Mandible / Materials Testing / Statistics, Nonparametric / Stress, Mechanical / Time Factors (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21691614 ● Search Scopus @ Elsevier (PMID): 21691614 (PubMed: 21691614)
25.	Hideki Suito, Yoritoki Tomotake, Megumi Watanabe, Daisuke Nagao, Yuichi Ishida and Tetsuo Ichikawa : Survival of immediate implant restoration: A retrospective study through 9-year-observation, Journal of Prosthodontic Research, Vol.55, No.3, 141-145, 2011. (Summary) The purpose of this retrospective study was to assess the implant survival rate and the risk factors associated with implant failure in patients who had undergone immediate implant restoration. We performed a retrospective review and an outcome assessment of all patients who received immediate implant restoration between 2000 and 2010 in our department at Tokushima University Hospital. The patients were divided into groups on the basis of the predictor variables: age, gender, implant location, and number of implants per jaw. The cumulative implant survival rate in the paired groups was determined by using Kaplan-Meier analysis and the log-rank test. Cox proportional hazards model was subsequently used to identify exposures associated with implant failure. Using the Kaplan-Meier method, the survival rates at 1, 3, and 9 years were calculated to be 98.8%, 98.0%, and 94.7%, respectively. No statistically significant association was observed between the implant survival rates and the predictor variables: gender, age, location, and number of implants. Immediate implant restoration is a reliable prosthetic procedure with an acceptable survival rate compared to the conventional implant procedure. (Keyword) Adult / Aged / Dental Implants / Female / Humans / Kaplan-Meier Estimate / Male / Middle Aged / Proportional Hazards Models / Prosthesis Failure / Retrospective Studies / Time Factors (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jpor.2010.10.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21300587 ● Search Scopus @ Elsevier (PMID): 21300587 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jpor.2010.10.004 (DOI: 10.1016/j.jpor.2010.10.004, PubMed: 21300587)
26.	Yuichi Ishida, Teruaki Ito, Hidenobu Nishinaka, Yutaka Sato, Yoritoki Tomotake, Tetsuo Ichikawa and Kazuo Arai : Devalopment and Evaluation of a Computer-assisted Navigation System Equipped with a Motion Sensor in Implant Dentistry, Journal of Japanese Society of Oral Implantology, Vol.23, No.4, 715-722, 2010. (Summary) 本研究では，3次元的な角度変化を計測できる姿勢検出センサを用いて開発を行った簡易的なインプラント埋入ナビゲーションシステムを開発した．本稿では，本システムの概要について紹介する．また，インプラント埋入の経験のない歯科医師を対象として，外科用ガイドプレートと本ナビゲーションシステムを用いてインプラント窩の形成を行う実験の結果について報告し，本システムの有用性と将来性について述べる． (Keyword) computer-assisted / navigation sysytem / implant / motion control sensor (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680481775744 (CiNii: 1390282680481775744)
27.	Jing Li, Yoshihito Naitou, Jian-Rong Chen, Takaharu Goto, Yuichi Ishida, Takanori Kawano, Yoritoki Tomotake and Tetsuo Ichikawa : New glass polyalkenoate temporary cement for cement-retained implant restoration: Evaluation of elevation and retentive strength, Dental Materials Journal, Vol.29, No.5, 589-595, 2010. (Summary) The purpose of this study was to evaluate four luting agents for cement-retained implant restorations in two aspects: post-cementation elevation of the superstructure and the retentive strength before and after thermocycling and mechanical cycling. The four evaluated luting agents were: new glass polyalkenoate hard-type (GH) and soft-type (GS) cements, polycarboxylate hard-type (HH) and soft-type (HS) cements. Elevation and retentive strength were measured using a CCD laser displacement sensor and a universal testing machine respectively. Elevation increased in this order: GH, GS, HH, and HS. Thermal and mechanical stresses significantly decreased retentive strength, and the mean values exhibited by GH were significantly higher than the other luting agents. The novel glass polyalkenoate cements (hard- and soft-type) experimentally prepared in the present study augured well as luting agents by virtue of their reduced film thickness and their excellent post-cementation retention and elevation. (Keyword) Aluminum / Aluminum Silicates / Cementation / Dental Abutments / Dental Bonding / Dental Implants / Dental Prosthesis Retention / Dental Prosthesis, Implant-Supported / Dental Stress Analysis / Denture, Partial, Fixed / Fluorine / Glass Ionomer Cements / Gold Alloys / Humans / Lasers / Materials Testing / Palladium / Polycarboxylate Cement / Silver / Stress, Mechanical / Surface Properties / Temperature (Link to Publication Site) ● Publication site (DOI): 10.4012/dmj.2009-102 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20877129 ● Search Scopus @ Elsevier (PMID): 20877129 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2009-102 (DOI: 10.4012/dmj.2009-102, PubMed: 20877129)
28.	Toshiya Kashiwabara, Takaharu Goto, Yutaka Sato, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : A new method to prevent the corrosion of dental materials, during disinfection using functional water: Sacrificial protection, Journal of Prosthodontic Research, Vol.54, No.3, 147-149, 2010. (Summary) This paper demonstrates a simple method using sacrificial protection for preventing the corrosion of dental metals. Dental metals are directly connected or/and wound with a pure commercial aluminum/zinc wire/plate with high ionization tendency, before their immersion into oxidizing functional water. Dental materials such as Co-Cr alloy wires, stainless steel, and Au-Ag-Pd alloys did not corrode when this method was used. Thus, this method is very simple and effective for preventing corrosion of dental metals during disinfection using functional water. (Keyword) Corrosion / Dental Alloys / Disinfection / Stainless Steel / Water (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jpor.2010.01.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20189474 ● Search Scopus @ Elsevier (PMID): 20189474 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jpor.2010.01.004 (DOI: 10.1016/j.jpor.2010.01.004, PubMed: 20189474)
29.	Yoritoki Tomotake, Yuichi Ishida, 後藤崇晴, Kan Nagao and Tetsuo Ichikawa : 磁石固定式上部構造におけるインプラント支持歯槽骨の光弾性応力解析, The Journal of the Japanese Society of Magnetic Applications in Dentistry, Vol.19, No.1, 39-46, 2010.
30.	Yuri Yoshida, Yasuhiko Morita, Eiichi Honda, Yoritoki Tomotake and Tetsuo Ichikawa : Evaluation of Measurement Accuracy in Imaging Using a Cone-beam CT, Journal of Japanese Society of Oral Implantology, Vol.22, No.1, 3-14, 2009. (Keyword) cone-beam CT / the number and sites of implants placed / geometric / accuracy (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205505214976 (CiNii: 1390001205505214976)
31.	Tetsuo Ichikawa, Osamu Ishida, Megumi Watanabe, Yoritoki Tomotake and Hua Wei : A new retrieval system for cement-retained implant superstructures., Journal of Prosthodontics, Vol.17, No.6, 487-489, 2008. (Summary) This article discusses two methods for improving the retrievability of cement-retained implant superstructures. One method involves incorporating a removal screw in the superstructure and the second method uses a small dimple on the abutment, accessed through a vent in the superstructure. (Keyword) Crowns / Dental Abutments / Dental Cements / Dental Debonding / Dental Implants / Dental Prosthesis Design / Dental Prosthesis Retention / Dental Prosthesis, Implant-Supported / Humans / surface properties (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1532-849X.2008.00329.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18544129 ● Search Scopus @ Elsevier (PMID): 18544129 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1532-849X.2008.00329.x (DOI: 10.1111/j.1532-849X.2008.00329.x, PubMed: 18544129)
32.	Wei Hau, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : Implant prostheses and adjacent tooth migration: preliminary retrospective survey using 3-dimensional occlusal analysis., The International Journal of Prosthodontics, Vol.21, No.4, 302-304, 2008. (Summary) Occlusal force analysis was retrospectively evaluated to clarify the proximal contact loss after fixed implant prosthesis placement. Twenty-eight patients (55 prostheses) with fixed implant prostheses in the posterior region were divided into 2 groups: proximal contact loss and unchanged groups. The occlusal force and its distribution were 3-dimensionally measured using the Dental Prescale system. A high proportion of lingual and anterior component forces and high occlusal force distribution in the intercanine region were observed in the contact loss group. The high occlusal force of the adjacent tooth may enhance the mesial migration. (Keyword) Bite Force / Dental Prosthesis, Implant-Supported / Dental Stress Analysis / Humans / Malocclusion / Mesial Movement of Teeth / Retrospective Studies (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18717086 ● Search Scopus @ Elsevier (PMID): 18717086 (PubMed: 18717086)
33.	Yuri Yoshida, Yasuhiko Morita, Eiichi Honda, Yoritoki Tomotake and Tetsuo Ichikawa : 小照射野歯科用CT装置での患者被曝線量の検討．被曝測定用X線フィルムを用いた解析．, Journal of Japanese Society of Oral Implantology, Vol.21, No.3, 439-446, 2008.
34.	Yuri Yoshida, Eiichi Honda, Yoritoki Tomotake, Daisuke Nagao and Tetsuo Ichikawa : Evaluation of Patient Dose in Imaging Using a Cone-beam CT for Dental Use., Journal of Japanese Society of Oral Implantology, Vol.20, No.2, 280-286, 2007. (Keyword) cone-beam CT / 3DX multi-image micro CT / flat panel detector / thermoluminescence dosimeter (TLD) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680485558656 (CiNii: 1390282680485558656)
35.	Yuri Yoshida, Yoritoki Tomotake, Megumi Watanabe, Daisuke Nagao and Tetsuo Ichikawa : Evaluation of Factors Affecting the Value of a New Wireless Resonance, Journal of Japanese Society of Oral Implantology, Vol.19, No.4, 446-452, 2006.
36.	Chen Jianrong, Kan Nagao, Yoritoki Tomotake and Tetsuo Ichikawa : Influence of a Vent Hole on the Retentive Force of a Cement-retained Superstructure before/after Thermocycling, Prosthodontic Research & Practice, Vol.5, No.3, 157-160, 2006. (Summary) <B>Purpose:</B> The purpose of this study was to evaluate the influence of a vent hole on the retentive force of a cement-retained superstructure to an abutment.<BR><B>Methods:</B> The retentive force of superstructures with/without a vent hole, retained using one of two luting cements, was measured using a universal testing machine both before and after thermocycling<BR><B>Results:</B> The retentive force of the cement-retained superstructure with the vent hole was greater than that of the cement-retained superstructure without the vent hole. While the retentive force decreased significantly after thermocycling, the size of the vent hole had little influence on the retentive force.<BR><B>Conclusion:</B> It was concluded that placement of a vent hole in the superstructure is useful, with little adverse effect on the retentive force of the restoration. (Keyword) retentive force / cement-retained superstructure / vent hole / thermocycling (Link to Publication Site) ● Publication site (DOI): 10.2186/prp.5.157 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205195009152 ● Search Scopus @ Elsevier (DOI): 10.2186/prp.5.157 (DOI: 10.2186/prp.5.157, CiNii: 1390001205195009152)
37.	Yoritoki Tomotake : A Case of Dental Implant Treatment with Sinus Lift for the Maxillary Molar Sites, The Journal of the Japan Prosthodontic Society, Vol.49, No.2, 314-317, 2005. (Summary) Patient: Implant treatment with sinus lift was conducted in a 53-year-old male patient who had bilateral edentulous posterior maxilla with a limited bone volume of the sinus floor. One year later, the mobility at the anterior teeth of the maxilla increased and then decreased due to occlusal adjustment. The left posterior teeth of the mandible were extracted due to severe periodontitis and two implants were placed.<BR>Discussion: In this case, the patient was highly satisfied with the above treatment.When the eccentric movement is guided by natural teeth in implant oral rehabilitation, it is important for the long-term results to consider the change of the occlusal contact.<BR>Conclusion: Implant treatment with bone augmentation is useful to obtain excellent clinical results in spite of the commensurate difficulties for the patient. (Keyword) implant treatment / sinus lift / occulusal contact (Link to Publication Site) ● Publication site (DOI): 10.2186/jjps.49.314 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15858330 ● CiNii @ National Institute of Informatics (CRID): 1390001204411898752 ● Search Scopus @ Elsevier (PMID): 15858330 ● Search Scopus @ Elsevier (DOI): 10.2186/jjps.49.314 (DOI: 10.2186/jjps.49.314, PubMed: 15858330, CiNii: 1390001204411898752)
38.	Tetsuo Ichikawa, 佐藤博信, 安田登, 服部正巳, 尾関雅彦, Yoritoki Tomotake, 秀島雅之, 佐藤裕二, 窪木拓男, 和気裕之 and 大山喬史 : 日本補綴歯科学会でいまどうして症型分類なのか, Practice in Prosthodontics, Vol.37, No.6, 639-645, 2004. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572261550747852672 (CiNii: 1572261550747852672)
39.	Hua Wei, Yoritoki Tomotake, Kan Nagao, Takafumi Ohguri, Daisuke Nagao and Tetsuo Ichikawa : In vitro Study of Stress Distribution on Additional Posterior Mandibular Implants, Prosthodontic Research & Practice, Vol.3, No.1, 84-91, 2004. (Summary) Purpose : This in vitro study investigated the influence of implant splinting on stress distribution in two experimental implant-bone models.Materials and Methods : Two experimental implant-bone models simulated the original Brånemark model with four implants between the mental foramina and one additional implant placed on each side posterior to the mental foramen. The stress distribution on each implant in the models was examined by applying a static load to the superstructure. Three types of superstructures were studied to determine the effect of additional implants in the posterior region : 1) a metal superstructure supported by all six implants (Full dental arch ; Metal FDA) ; 2) the same type of superstructure made of resin instead of metal (Resin FDA) ; and 3) the metal superstructure supported by four anterior implants, with the conical abutments removed from the two posterior implants (Short dental arch ; Metal SDA).Results : Regardless of the type of superstructure tested, high stress was observed around each loaded implant. The highest stress was concentrated on the distal implants of the FDA compared to the stress on the anterior implants.Conclusion : The elevated stress concentration around the implants found in the present in vitro study is considered to be one of the reasons for the high failure rate of additional posterior mandibular implants. (Keyword) stress distribution / splinting / posterior installation of implant / mandibular distortion (Link to Publication Site) ● Publication site (DOI): 10.2186/prp.3.84 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680171778304 ● Search Scopus @ Elsevier (DOI): 10.2186/prp.3.84 (DOI: 10.2186/prp.3.84, CiNii: 1390282680171778304)
40.	齋賀明彦, Tetsuo Ichikawa, Yoritoki Tomotake, Hideo Kanitani and Seiko Hongama : スクリュー締め付け回転角/トルク計測によるインプラント上部構造の適合性評価, The Journal of the Japan Prosthodontic Society, Vol.47, No.2, 353-360, 2003. (Summary) Purpose: Misfit of superstructure-supported osseointegrated implants causes adverse stress in the prosthesis, components, and surrounding bone. A passive fit of the implant-supported prosthesis is essential for successful long-term osseointegration. Various clinical methods for evaluating the fit of implant-supported prostheses have been suggested. However, the methods have little scientific evidence to determine the acceptable fit. The present study evaluated the misfit of implant-supported prostheses by measuring the rotational angle/tightening torque in screwing the prosthesis on master models.<BR>Materials and Methods: Twenty-four implant-supported prostheses (3 single standing, 20 fixed partial, 1 full bridge) of fourteen patients were evaluated using a custom-made rotational angle/ tightening torque measuring apparatus on the master models. The influence of the order of tightening and unit number on the value was also evaluated.<BR>Results: The mean of the rotational angle/tightening torque was 2.6 (SD: 0.6) degree/Ncm in all prostheses. The value was significantly higher than that in the abutment screw as a control. The order of tightening and unit number did not significantly affect the values.<BR>Conclusions: The results suggest that measurements of rotational angle/tightening torque be useful for evaluating the fit of implant-supported prostheses. Misfit of the prostheses was below the level of acceptable fit. (Keyword) implant / superstructure / misfit / rotational angle / tightening torque (Link to Publication Site) ● Publication site (DOI): 10.2186/jjps.47.353 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204412927616 ● Search Scopus @ Elsevier (DOI): 10.2186/jjps.47.353 (DOI: 10.2186/jjps.47.353, CiNii: 1390001204412927616)
41.	Akihiko Saika, Tetsuo Ichikawa, Yoritoki Tomotake, Hideo Kanitani and Seiko Hongama : スクリュー締め付け回転角/トルク計測によるインプラント上部構造の適合性評価, The Journal of the Japan Prosthodontic Society, Vol.47, No.2, 353-360, 2003.
42.	Yoritoki Tomotake, Tetsuo Ichikawa, Hideo Kanitani, Masahide Nakao and Naoki Kitaoka : Dynamics of bone marrow pressure with tapping of titanium and hydroxyapatite implants in rabbit, Clinical Oral Implants Research, Vol.13, No.2, 221-224, 2002. (Summary) The purpose of the present study was to evaluate the difference in stress transfer between titanium (Ti) and hydroxyapatite (HA) by the measurement of bone marrow pressure using a catheter pressure transducer. Ti and HA implants were inserted in the tibiae of rabbits. A hole of 1 mm in diameter was drilled in the bone and a fine catheter pressure transducer was placed in the bone marrow through a tube. The top of the abutment was vertically tapped with an impulse hammer, and the acceleration signal from the hammer and pressure signal from the catheter pressure transducer were examined. The time of contact (impulse duration) recorded in the impulse with Ti and HA was 166+/-17 micro sec and 164 +/- 17 micro sec, respectively. Maximum bone marrow pressure (BMP) with Ti and HA was 54.2 +/- 32.6 and 47.5 +/- 10.0 mmHg, respectively. Variation of the BMP with Ti was significantly larger than that with HA (P < 0.05). A negative correlation coefficient between impulse duration and BMP was found. The results of the present study suggest that the stress transfer is different between Ti and HA implants using dynamics of the bone marrow pressure. (Keyword) Acceleration / Animals / Biocompatible Materials / Biomechanics / Bone Marrow / Dental Abutments / Dental Implantation, Endosseous / Dental Implants / Durapatite / Male / Percussion / Pressure / Rabbits / Signal Processing, Computer-Assisted / Statistics as Topic / Stress, Mechanical / Tibia / Titanium / Transducers, Pressure (Link to Publication Site) ● Publication site (DOI): 10.1034/j.1600-0501.2002.130213.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11952743 ● Search Scopus @ Elsevier (PMID): 11952743 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1600-0501.2002.130213.x (DOI: 10.1034/j.1600-0501.2002.130213.x, PubMed: 11952743)
43.	Akihiko Saika, Tetsuo Ichikawa, Naoki Kitaoka, Yoritoki Tomotake and Nobuhiro Hamaguchi : Influence of Screw Tightening on Stress Distribution around Implant:An in vitro Experiment, Journal of Japanese Society of Oral Implantology, Vol.15, No.1, 1-9, 2002. (Summary) Screw tightening of the superstructure of osseointegrated implants often produces unsuitable strain on the prosthesis and surrounding bone The purpose of this study was to investigate the effects of screw tightening on surrounding bone in several conditions <br/> Three Steri-oss® implants were placed in an acrylic resin experimental model and a three-unit framework was fabricated on the implants The fit of the framework was judged excellent by laboratory microscopy Ten strain gauges were attached on the experimental model surface around the implants The strain was measured after every screw was tightened by a custom-designed torque controller Static and dynamic strain was recorded Each test was repeated five times under the same conditions <br/> The results were as follows:<br/> 1 The order of screw tightening affected stress distribution The distribution was unequal and asymmetrical to the implants <br/> 2 Staged tightening of the screws decreased the sum of all strains <br/> 3 Tightening torque does not affect stress distribution <br/> 4 Misfit of the abutment/superstructure joint increased the sum of all strains <br/> 5 Strain induced by tightening of the second or third implant was greater than that by tightening the first one (Keyword) implant / screw tightening / strain / experimental model / misfit (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.15.1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205510335744 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.15.1 (DOI: 10.11237/jsoi.15.1, CiNii: 1390001205510335744)
44.	Yoritoki Tomotake, Hideo Kanitani, Masahide Nakao and Tetsuo Ichikawa : インパルス衝撃応答と骨髄圧によるオッセオインテグレーションの評価, The Journal of the Japan Prosthodontic Society, Vol.46, No.1, 110-119, 2002. (Summary) Purpose: The purpose of the present study was to evaluate the difference for stress transfer between titanium (Ti) and hydroxyapatite (HA) implants by measuring bone marrow pressure using a catheter pressure transducer, and then to clarify the relationship between the histological and biomechanical properties.<BR>Methods: Ti and HA implants were inserted in the tibiae of rabbits. About 10 weeks following implantation, a hole, 1mm in diameter, was drilled in the bone distal to the implant, and a fine catheter pressure transducer was placed in the bone marrow through a tube. After the abutment was connected to the implant, the top of the abutment was vertically tapped with an impulse hammer, and the acceleration signal from the hammer, and the pressure signal from the catheter pressure transducer, were examined. In addition, histological examination was performed on each implant.<BR>Results: Maximum bone marrow pressure (BMP) with Ti and HA was 117.4±54.8mmHg and 90.3±30.6mmHg, respectively. A significant difference was observed (p<0.05). Moreover, variation of the BMP with Ti was significantly larger than that with HA (p<0.05). A negative correlation coefficient between the time of contact recorded in the impulse and BMP was found with Ti. As to histological examination of the bone structure around several implants, no significant difference was found between Ti and HA implants.<BR>Conclusion: The results show that the stress transfer is different between Ti and HA implants, using dynamics of bone marrow pressure. Little relation was found between biomechanical properties and histological views. The present study suggests that the evaluation of osseointegration requires consideration of biomechanical properties. (Keyword) titanium implant / hydroxyapatite implant / osseointegration / impulse response / bone marrow pressure (Link to Publication Site) ● Publication site (DOI): 10.2186/jjps.46.110 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204412418816 ● Search Scopus @ Elsevier (DOI): 10.2186/jjps.46.110 (DOI: 10.2186/jjps.46.110, CiNii: 1390001204412418816)
45.	Yoritoki Tomotake, Osamu Ishida, Hideo Kanitani and Tetsuo Ichikawa : Immediate implant-supported oral rehabilitation using a photocurable plastic skull model and laser welding: A technical Note of Screw Retained type: Part 1, The International Journal of Prosthodontics, Vol.15, No.3, 303-306, 2002. (Summary) This article describes a new procedure for immediate implant-supported oral rehabilitation using a photocurable resin skull model and a laser-welding apparatus. Preoperatively, the framework was fabricated on a photocurable resin skull model produced from a CT scan and individually designed guide template. The implants were immediately placed using the guide template; laser welding connected the components of framework. Despite the custom-made prosthesis, the total treatment from implant placement to superstructure placement can be completed within only 1 day. This procedure for immediate implant-supported oral rehabilitation using a photocurable resin skull model and a laser-welding apparatus may be useful for any implant system and patient. (Keyword) TITANIUM FRAMEWORKS / EDENTULOUS JAW / PLACEMENT (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12066496 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036559364 (PubMed: 12066496, Elsevier: Scopus)
46.	Hideo Kanitani, Yoritoki Tomotake, Wigianto Rudi, Naeko Kawamoto and Tetsuo Ichikawa : Bone changes around hydroxyapatite and titanium implants after abutment placement in rabbits, --- observations using histological and three-dimensional examinations ---, The Journal of Oral Implantology, Vol.26, No.4, 251-256, 2000. (Summary) We have previously developed a computer-aided system for examination of the three-dimensional bone structure around implants and observed the bone changes in the healing period after implant placement. This paper describes the bone changes around hydroxyapatite (HA) and titanium (Ti) implants after abutment placement using histological and three-dimensional examinations. Twenty-four HA and Ti implants were embedded in the tibias of adult male New Zealand white rabbits. After 8 weeks, the abutment had passed through periosteum and was placed under the skin. Rabbits were sacrificed 4 and 8 weeks following abutment placement. In conclusion, histological examination showed that, at 4 weeks after abutment placement, bone resorption around the implant neck was seen in both HA and Ti implants, and at 8 weeks, excessive bone formation was seen around the implant neck. Three-dimensional bone examination showed that abutment placement may affect bone formation and cause additional bone hypertrophy in the bone marrow area. (Keyword) Animals / Bone Resorption / Computer Graphics / Dental Abutments / Durapatite / Hyperostosis / Imaging, Three-Dimensional / Implants, Experimental / Male / Rabbits / Tibia / Time Factors / Titanium (Link to Publication Site) ● Publication site (DOI): 10.1563/1548-1336(2000)026<0250:BCAHAT>2.3.CO;2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11831230 ● Search Scopus @ Elsevier (PMID): 11831230 ● Search Scopus @ Elsevier (DOI): 10.1563/1548-1336(2000)026<0250:BCAHAT>2.3.CO;2 (DOI: 10.1563/1548-1336(2000)026<0250:BCAHAT>2.3.CO;2, PubMed: 11831230)
47.	Akihiko Saika, Miyuki Noda, Tetsuo Ichikawa, Naeko Kawamoto, Hideo Kanitani and Yoritoki Tomotake : インプラント上部構造のPassive fit適合試験法の検討, Journal of Japanese Society of Oral Implantology, Vol.13, No.3, 522-529, 2000.
48.	Hideo Kanitani, Yoritoki Tomotake, Naeko Kawamoto, 野田美幸, 斎賀明彦 and Tetsuo Ichikawa : 高周波電気メスがインプラント周囲骨組織に及ぼす影響について, Journal of Japanese Society of Oral Implantology, Vol.12, No.3, 343-349, 1999.
49.	野田美幸, Masatoshi Ishikawa, Tetsuo Ichikawa, Hideo Kanitani, Yoritoki Tomotake, Naeko Kawamoto, Kan Nagao, Fumiaki Kawano and Masaru Hada : Influence of Implant Connection on Mandibular Flexure in Jaw Movement, --- Three-dimensional Finite Element Analysis ---, The Journal of the Japan Prosthodontic Society, Vol.42, No.4, 580-585, 1998. (Keyword) mandibular flexure / finite element method / implant / connection
50.	Fumiaki Kawano, Takao Hanawa, Kenji Oka, Yoritoki Tomotake, Kenzo Asaoka, Tetsuo Ichikawa and Naoyuki Matsumoto : Estimation of residual stress in dental porcelain by Laser-Raman spectroscopy, Dental Materials Journal, Vol.17, No.1, 41-50, 1998. (Keyword) Dental porcelain / Residual stress / Laser-Raman spectroscopy
51.	Yoritoki Tomotake, Fumiaki Kawano, Kan Nagao, 川端修一, 佐藤修斎, 秋田一郎, 川田雄祥, 猪子寿一 and 松本直之 : Shear Bond Strength of Abrasion-resistant Plastic Teeth to Self-curing Resin, --- Comparison of Bonding Agents ---, Shikoku Dental Research, Vol.9, No.2, 115-122, 1997. (Keyword) 硬質レジン / 即時重合レジン / 結合強さ / プライマー
52.	Kenji Oka, Takao Hanawa, Masayuki Kon, Hae-Hyoung Lee, Fumiaki Kawano, Yoritoki Tomotake, Matsumoto Naoyuki and Kenzo Asaoka : Effect of barium in porcelain on bonding strength of titanium-porcelain system, Dental Materials Journal, Vol.15, No.2, 111-120, 1996.
53.	Kenji Oka, Fumiaki Kawano, Yoritoki Tomotake, Masayuki Kon, Takao Hanawa, Kenzo Asaoka and Naoyuki Matsumoto : Effect of ion-exchange on fracture toughness and physical strength of dental porcelains, The Journal of the Japan Prosthodontic Society, Vol.40, No.3, 598-603, 1996. (Keyword) dental porcelain / ion-exchange / fracture toughness / reliability / Weibull distribution
54.	Fumiaki Kawano, Kan Nagao, Masazumi Noda, Kenji Oka, Yoritoki Tomotake, Shuichi Kawabata, Naoyuki Matsumoto, Masayuki Kon and Kenzo Asaoka : Shock-absorbing Behavior of Soft Denture Liner, --- Part 2 Influence of Lining Design on Shock Absorbability ---, The Journal of the Japan Prosthodontic Society, Vol.40, No.3, 501-507, 1996. (Keyword) soft denture liner / lining method / acceleration / rising time / free drop test
55.	Fumiaki Kawano, Kan Nagao, Kenji Oka, Yoritoki Tomotake, Masayuki Kon, Kenzo Asaoka and Naoyuki Matsumoto : Studies on Soft Denture Liner by using Viscoelastic Analysis, --- Part 3. Effect of Viscosity of Soft Lining Materials on Stress Distribution in Denture Supporting Structures ---, The Journal of the Japan Prosthodontic Society, Vol.39, No.6, 1004-1009, 1995. (Keyword) viscoelastic finite element method / supporting structure / soft denture liner / viscosity / stress distribution
56.	Sanshiro Inoue, Fumiaki Kawano, Kan Nagao, Kenji Oka, Yoritoki Tomotake and Naoyuki Matsumoto : A Basic Study on Pressure Distribution of Supporting Structures under Complete Denture, --- Part 3. Influence of Occlusal Surface of Artificial Posterior Teeth on Pressure Distribution ---, The Journal of the Japan Prosthodontic Society, Vol.39, No.3, 501-510, 1995. (Keyword) pressure distribution / complete denture / posterior artificial teeth / occlusal surface

Review, Commentary:

1.	Yoritoki Tomotake and Tetsuo Ichikawa : インプラント周囲溝に歯磨剤配合の顆粒は影響するか, Dental Outlook, Vol.135, No.2, 356-363, Feb. 2020. (Keyword) 剤形歯科インプラント(有害作用) 歯垢歯磨剤歯磨きインプラント周囲炎顆粒剤実態調査ヒト歯学
2.	津村希望, Yoritoki Tomotake, 石田修 and Tetsuo Ichikawa : 基本的な歯科技工の``勘どころ'' -臨床例から得られた具体的アドバイスをとおして熟練歯科技工士から新人歯科技工士への技術の継承を図る第8回上顎前歯部のインプラント補綴から``技工操作の総合的な調整''を学ぶ, The International Journal of Dental Technology, Vol.43, No.2, 208-219, Feb. 2015.
3.	津村希望, Yoritoki Tomotake, 石田修 and Tetsuo Ichikawa : 基本的な歯科技工の``勘どころ'' -臨床例から得られた具体的アドバイスをとおして熟練歯科技工士から新人歯科技工士への技術の継承を図る第3回上顎片側中間欠損に対するパーシャルデンチャーから``技師の設計''を学ぶ, The International Journal of Dental Technology, Vol.42, No.9, 1000-1009, Sep. 2014.

Proceeding of International Conference:

1.	Prananingrum Widyasri, Yoritoki Tomotake, Yoshihito Naitou, Kazumitsu Sekine, Kenichi Hamada and Tetsuo Ichikawa : Sintering Time and Its Influence on Moldless-Processed Porous Titanium's Properties, 94th General Session and Exhibition of the International Association for Dental Research, Seoul, Jun. 2016.
2.	Takaharu Goto, Yoritoki Tomotake, Yuichi Ishida, Nobuaki Higaki, Kan Nagao and Tetsuo Ichikawa : Functional Significance of the Main Occluding Area for Partially Edentulous, 16th Biennial Meeting of International College of Prosthodontists, Sep. 2015.
3.	Yuki Iwawaki, Noriko Mizusawa, Yoritoki Tomotake, Tetsuo Ichikawa and Katsuhiko Yoshimoto : Mechanical stress - responsive microRNA, The 3rd ASEAN plus and TOKUSHIMA Joint International Conference, Makassar, Indonesia, Dec. 2014.
4.	Takaharu Goto, Yoritoki Tomotake, Yuichi Ishida, Nobuaki Higaki, Kan Nagao and Tetsuo Ichikawa : Clinical significance of the main occluding in prosthodontic treatment, The 3rd ASEAN plus and TOKUSHIMA Joint International Conference on ``Strategic Achievement of Oral Sciences and Promotion of Quality of Life'', Makassar, Dec. 2014.
5.	Takaharu Goto, Yuichi Ishida, Megumi Watanabe, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : Location of the main occluding area after implant treatment, 38th Annual Conference of The European Prosthodontic Association, Istanbul, Sep. 2014.
6.	Yuichi Ishida, Hideki Suito, Yoritoki Tomotake and Tetsuo Ichikawa : Prediction of prosthetic complications in the superstructure by assessing changes in the provisional restoration., The 15th Biennnial Meeting of International College of Prosthodontics, Turin, Sep. 2013.
7.	Yuichi Ishida, 水頭英樹, Yoritoki Tomotake and Tetsuo Ichikawa : Prediction of prosthetic complications in the superstructure by assessing changes in the provisional restoration., The 15th Biennnial Meeting of International College of Prosthodontics, Turin, Sep. 2013.
8.	Osamu Isida, Yoritoki Tomotake and Tetsuo Ichikawa : The development of implant superstructures: especially considering the retrievability., Programs and Abstracts of Biennial Meeting of Asian Academy of Prosthodontics., Vol.8, 135, Dec. 2012.
9.	Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : Systematic literature review on sensation of osseointegrated implants., Programs and Abstracts of Biennial Meeting of Asian Academy of Prosthodontics., Vol.8, 137, Dec. 2012.
10.	Yoritoki Tomotake, Takaharu Goto and Tetsuo Ichikawa : The Relationship between Main Occluding Area and Prosthetic Complains in Implant Superstructure., The 8th Biennial Meeting of Asian Academy of Prosthodontics, Vol.8, 139, Chennai, Dec. 2012.
11.	Hideki Suito, Takaharu Goto, Yuki Iwawaki, Yoritoki Tomotake and Tetsuo Ichikawa : Oral factors affecting titanium elution and corrosion; in vitro study using SBF solution., ASEAN plus and TOKUSHIMA Joint International Conference"Strategic Achievement of Oral Sciences and Promotion of Quality of Life", Dec. 2012.
12.	Takaharu Goto, Nobuaki Higaki, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : Sensation of osseointegrated implants: literature review and new neurophysiological approach, ASEAN plus and TOKUSHIMA Joint International Conference"Strategic Achievement of Oral Sciences and Promotion of Quality of Life", Dec. 2012.
13.	Takaharu Goto, Kan Nagao, Yuichi Ishida, Yoritoki Tomotake and Tetsuo Ichikawa : Influence of Attachments On Load Transfer in Implant Overdentures: Effect Of Denture Rigidity, 14th Meeting of International College of Prosthodontists, Hawaii, Sep. 2011.
14.	Kenichi Hamada, Yoshihito Naitou, Daisuke Nagao, Yoritoki Tomotake, Tetsuo Ichikawa and Kenzo Asaoka : Properties of Porous Titanium using Moldless Process, International Joint Symposium on Oral Science, Denpasar, Dec. 2010.
15.	Takaharu Goto, Kan Nagao, Yuichi Ishida, Yoshihito Naitou, Yoritoki Tomotake and Tetsuo Ichikawa : Observation of the Main ccluding Area with Partually bentate, changes before/after Prosthetic Treatments., 6th Scientific Meeting Asian Academy of Osseointegration, Seoul, Nov. 2010.
16.	Yoshihito Naitou, Kenichi Hamada, Takaharu Goto, Megumi Watanabe, Daisuke Nagao, Yoritoki Tomotake and Tetsuo Ichikawa : Powder-size effect on biocompatibility of porous-titanium produced using moldless-process, 19th Annual Scientific Meeting European Assocoation for Osseintegration, Glasgow, Oct. 2010.
17.	Takaharu Goto, Kan Nagao, Yuichi Ishida, Yoshihito Naitou, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : Influence of Attachments on Load Transfer in Implant Overdentures, 19th Annual Scientific Meeting European Assocoation for Osseintegration, Glasgow, Oct. 2010.
18.	Kenichi Hamada, Yoshihito Naitou, Daisuke Nagao, Yoritoki Tomotake, Tetsuo Ichikawa and Kenzo Asaoka : Smart process of porous titanium for tailor-made medical and dental devices, Thermec (International Conference on Processing & Manufacturing of Advanced Materials) 2009, Berlin, Aug. 2009.
19.	Yoshihito Naitou, Daisuke Nagao, Yoritoki Tomotake, Kenichi Hamada, Kenzo Asaoka and Tetsuo Ichikawa : Bioactivity of porous titanium prodeced by a newly developing moldless process, 2nd International Symposium and Workshop "The future Direction of Oral Sciences in the 21st Century", Tokushima, Dec. 2007.
20.	Yoshihito Naitou, Kenichi Hamada, Daisuke Nagao, Yoritoki Tomotake, Tetsuo Ichikawa and Kenzo Asaoka : Bioactivity of porous titanium produced using moldless process, 6th International Symposium on Titanium in Dentistry, Kyoto, Jul. 2007.
21.	Kenichi Hamada, Yoshihito Naitou, Daisuke Nagao, Yoritoki Tomotake, Tetsuo Ichikawa and Kenzo Asaoka : Moldless Process of Producing Porous Titanium for Dental Applications, 6th International Symposium on Titanium in Dentistry, Kyoto, Jun. 2007.
22.	Daisuke Nagao, Katsuhiko Yoshimoto, Yoritoki Tomotake, Megumi Watanabe, Y Yoshijima and Tetsuo Ichikawa : Gene expression in a mouse osteoblast like cell line in response to compressing force., 11th International College of Prosthodontists, Crete, Greece, May 2005.
23.	Takao Hanawa, Fumiaki Kawano, Masayuki Kon, Kenji Oka, Yoritoki Tomotake, Kenzo Asaoka and Matsumoto Naoyuki : Estimation of residual stress of porcelain by laser Raman spectroscopy, Journal of Dental Research, Vol.75, No.Spec, 125, San Francisco, Mar. 1996.
24.	Kenji Oka, Yoritoki Tomotake, Fumiaki Kawano, Masayuki Kon and Kenzo Asaoka : Effect of ion exchange on Weibull parameter of dental porcelains, Journal of Dental Research, Vol.74, No.Spec, 489, Singapore, Jun. 1995.

Proceeding of Domestic Conference:

1.	Yasufumi Nishikawa, Masami Ninomiya, Hiromichi Kawano, Yoritoki Tomotake and Hiromichi Yumoto : A case report of comprehensive periodontal treatment for a generalized chronic periodontitis patient without posterior occlusal support, 第67回春季日本歯周病学会学術大会プログラムおよび演題抄録集, Vol.66, 146, Apr. 2024. (Keyword) periodontitis / Chronic Periodontitis / Comprehensive periodontal treatment
2.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake, Hiromichi Yumoto and Tetsuo Ichikawa : 高グルコース培養したヒト歯肉線維芽細胞に Candidalysin誘導性ROSがもたらす影響について, 四国歯学会第63回例会, Mar. 2024.
3.	天羽紗生, 武川香織, 藤田晶帆, 福本仁美, 清野方子, 佐原久美子, Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake and Tetsuo Ichikawa : 専門的口腔衛生管理によりインプラント周囲粘膜の違和感が改善した1症例, 四国歯学会第63回例会, Mar. 2024.
4.	Susumu Abe, Naito Kurio, Yoritoki Tomotake, Kumiko Kamada, Toshinori Okawa, Eiji Yamauchi, Youji Miyamoto and Tetsuo Ichikawa : A case of implant-supported overdenture for severe bone defect of the mandible and vascularized fibular graft by carcinoma of the lower gingiva, 日本口腔インプラント学会誌第43回関東・甲信越支部学術大会, 105, Feb. 2024.
5.	Megumi Watanabe, Norikazu Minami, Yoritoki Tomotake and Tetsuo Ichikawa : 歯科用インプラント患者口腔内の溶出チタンの解析, 第43回日本口腔インプラント学会中国・四国支部学術大会, Oct. 2023.
6.	Hiromichi Kawano, Hideyuki Takano, 藤田晶帆, 福本仁美, 武川香織, Yasufumi Nishikawa, Yoritoki Tomotake and Tetsuo Ichikawa : 周術期口腔機能管理対象患者の口腔インプラントに対し適切に治療介入するための取り組み, 第43回中国・四国支部学術大会, Oct. 2023.
7.	Yuichi Ishida, 小西晴奈, Yuki Iwawaki, Yoritoki Tomotake and Tetsuo Ichikawa : Z世代と呼ばれる歯学部学生および研修歯科医に対する口腔インプラント治療に関するアンケート調査, 公益社団法人日本口腔インプラント学会, Sep. 2023.
8.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake and Tetsuo Ichikawa : 高グルコース負荷がヒト歯肉線維芽細胞における Candidalysin誘導性炎症関連因子の産生に与える影響, 第53回口腔インプラント学会学術大会, Sep. 2023.
9.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake, Hiromichi Yumoto and Tetsuo Ichikawa : ヒト歯肉線維芽細胞におけるCandidalysin誘導性ROSの産生性とその作用について, 四国歯学会第62回例会, Jul. 2023.
10.	武川香織, 藤田晶帆, 福本仁美, 鶴田真生, 清野方子, Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake and Hiromichi Yumoto : 高齢者における各種歯ブラシの歯垢除去効果について, 第66回春季日本歯周病学会学術大会(高松), May 2023.
11.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake, Hiromichi Yumoto and Tetsuo Ichikawa : 高グルコース負荷を行ったヒト歯肉線維芽細胞における Candidalysinの作用, 四国歯学会第 61回例会, Mar. 2023.
12.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント補綴の隣接欠損部に対して延長ポンティック形態を付与したジルコニア製べニアを用いた1症例, 第42回公益社団法人日本口腔インプラント学会中国・四国支部総会・学術大会, Nov. 2022.
13.	Yuki Iwawaki, Norikazu Minami, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : 表面処理されたチタン上における骨芽細胞様細胞のmicroRNA発現と細胞増殖への影響, 第52回公益社団法人日本口腔インプラント学会学術大会, Sep. 2022.
14.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake and Tetsuo Ichikawa : Investigation of the involvement of Candida albicans on pathogenesis of peri-implantitis, 第52回口腔インプラント学会学術大会, Sep. 2022.
15.	Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake, Hiromichi Yumoto and Tetsuo Ichikawa : Candidalysinがインプラント周囲炎の病態形成に与える影響について, 四国歯学会第60回例会, Jun. 2022.
16.	Yasufumi Nishikawa, Yuta Uemura, Hiromichi Kawano, Yoritoki Tomotake, Masami Ninomiya and Hiromichi Yumoto : Evaluation of mucosal thickness using digital image analysis after periodontal plastic surgery for peri-implant mucosa: A case report, 第65回春季日本歯周病学会学術大会プログラムおよび演題抄録集, Vol.64, 150, Jun. 2022. (Keyword) implant / Periodontal plastic surgery / Digital image analysis
17.	Rie Kido, Eijiro Sakamoto, Yuka Hiroshima, Mika Bandou, Jun-ichi Kido, Takahisa Ikuta, Masami Ninomiya, Yuji Inagaki, Yasufumi Nishikawa, Yoritoki Tomotake, Koji Naruishi and Hiromichi Yumoto : イムノクロマト法を用いたカルプロテクチン測定による歯周病およびインプラント疾患の診断, 四国歯学会第59回例会, Mar. 2022.
18.	Yoritoki Tomotake, Hiromichi Kawano, Yasufumi Nishikawa and Tetsuo Ichikawa : • 当大学病院口腔インプラントセンターにおける新来患者の臨床統計, 徳島歯科医学大会, Feb. 2022.
19.	福本仁美, 武川香織, Yasufumi Nishikawa, 湊晶帆, 鶴田真生, Hiromichi Kawano, Yoritoki Tomotake and Tetsuo Ichikawa : 臼歯部インプラント上部構造に対する各種歯ブラシの歯垢除去効果について, 第51回日本口腔インプラント学会学術大会, Dec. 2021.
20.	Hiromichi Kawano, 富永賢, Yasufumi Nishikawa, Yoritoki Tomotake and Tetsuo Ichikawa : 固定性から可徹性へのインプラント上部構造の補綴的介入による心理的・機能的変化, 第51回日本口腔インプラント学会学術大会, Dec. 2021.
21.	Yasufumi Nishikawa, Masami Ninomiya, Hiromichi Kawano, Yoritoki Tomotake and Hiromichi Yumoto : 限局型侵襲性歯周炎患者に対してリグロスとサイトランスグラニュールを併用した歯周組織再生療法を行い1年半経過した1症例, 日本歯周病学会中国四国3大学・日本臨床歯周病学会中国四国支部合同研修会, Nov. 2021. (Keyword) Aggressive periodontitis / Regroth / サイトランスグラニュール
22.	武川香織, 湊晶帆, 長岡仁美, 鶴田真生, 清野方子, Yasufumi Nishikawa, Hiromichi Kawano, Yoritoki Tomotake and Hiromichi Yumoto : 高齢者の口腔衛生管理における幅広植毛歯ブラシの有用性について, 第64回春季日本歯周病学会学術大会, May 2021.
23.	Yasufumi Nishikawa, Masami Ninomiya, Hiromichi Kawano, Yoritoki Tomotake and Hiromichi Yumoto : A case report of the periodontal regeneration technique in combination with REGROTH and Cytrans Granules and implant treatment for a patient with localized aggressive periodontitis, 第64回春季日本歯周病学会学術大会プログラムおよび演題抄録集, Vol.63, 119, May 2021. (Keyword) periodontal regeneration technique / REGROTH / Cytrans Granules / periodontitis
24.	Yuichi Ishida, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : フューチャー・デザイン手法を用いた終末期のインプラント治療への対応の検討, 第50回公益社団法人日本口腔インプラント学会記念学術大会, Sep. 2020.
25.	Yoritoki Tomotake, Yuichi Ishida, Susumu Abe, Megumi Watanabe, 富永賢, Yoshizo Matsuka, Youji Miyamoto and Tetsuo Ichikawa : 徳島大学病院口腔インプラント診療部門における臨床と研究への取り組み, Journal of Japanese Society of Oral Implantology, Sep. 2020.
26.	Yuki Iwawaki, Takaharu Goto, Norikazu Minami, Yoritoki Tomotake and Tetsuo Ichikawa : 異なる表面性状を持つチタン上での骨芽細胞におけるmicroRNA発現の同定, 第49回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2019.
27.	田口侑子, Hiromichi Kawano, 湊晶帆, 鶴田真生, 清野方子, 荒井安希, Yoritoki Tomotake and Tetsuo Ichikawa : Usefulness of the salivary multi test in the preoperative examination of the oral implant treatment., 日本口腔インプラント学会第38回中国四国支部学術大会, Nov. 2018.
28.	Gantumur Chimeddulam, Keisuke Nishigawa, Yoshihito Naitou, Junhel Dalanon, Afroz Shaista, 葉山莉香, Masamitsu Ohshima, Yoritoki Tomotake, Tetsuo Ichikawa and Yoshizo Matsuka : インプラントシステムの違いによるインプラント周囲骨吸収に関する長期放射線学的検討, The Journal of the Japan Prosthodontic Society, Jun. 2018.
29.	Kouhei Kamoi, Susumu Abe, Kenji Fujisawa, Yoritoki Tomotake, Eriko Horikawa, Eiji Yamauchi, Youji Miyamoto and Fumiaki Kawano : 着脱を容易にする機構を付与したセメント固定式上部構造を用いた1症例, 第37回公益社団法人日本口腔インプラント学会, Nov. 2017.
30.	荒井安希, 清野方子, Yoritoki Tomotake, 和田匡史, 高瀬維彦, Takaharu Goto, Megumi Watanabe and Tetsuo Ichikawa : 臼歯部インプラント補綴のセルフクリーニングに関する研究, 公益社団法人日本口腔インプラント学会第37回中国・四国支部学術大会, Nov. 2017.
31.	Ch. Gantumur, Keisuke Nishigawa, R. Hayama, Toyoko Tajima, Yoritoki Tomotake, Yoshihito Naitou, Tetsuo Ichikawa and Yoshizo Matsuka : Etiological investigation of the marginal bone loss on the peri-implant area: a retrospective cohort study, Tokushima University Bioscience Retreat, Sep. 2017.
32.	Megumi Watanabe, Norikazu Minami, 高瀬維彦, Yoritoki Tomotake and Tetsuo Ichikawa : The effect of ELF pulsed magnetic fields on osteoblast differentiation via MAP kinase pathways., 第47回公益社団法人日本口腔インプラント学会学術大会, Sep. 2017.
33.	Yoritoki Tomotake, 荒井安希, 清野方子, 内藤禎人, 田島登誉子, Takaharu Goto, 石田雄一 and Tetsuo Ichikawa : 歯磨剤に配合された顆粒成分のインプラント周囲溝への侵入性の調査, 第47回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2017.
34.	Henmi Yoko, Kazumitsu Sekine, Jinno Yohei, Jimbo Ryo, Yoshihito Naitou, Yoritoki Tomotake and Kenichi Hamada : 多孔性チタン編物の変形特性の異方性, 日本金属学会2017年春季大会, Mar. 2017.
35.	Horikawa Eriko, Susumu Abe, Kenji Fujisawa, Akira Takahashi, Eiji Yamauchi, Yoritoki Tomotake, Youji Miyamoto and Fumiaki Kawano : 単独歯インプラントの隣在歯の生存率に関する調査, 日本口腔インプラント学会中国・四国支部学術大会, 45, Nov. 2016.
36.	Henmi Yoko, Kazumitsu Sekine, Jinno Yohei, Jimbo Ryo, Yoshihito Naitou, Yoritoki Tomotake and Kenichi Hamada : 高い変形能を示す多孔性チタン織物の骨伝導能, 日本金属学会2016年秋季大会, Sep. 2016.
37.	檜垣宜明, Takaharu Goto, Yuki Iwawaki, 石田雄一, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : 咬合力維持における前頭前野の活動と感覚統合:インプラントと天然歯の比較, 第46回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2016.
38.	Yuki Iwawaki, Takaharu Goto, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : マウス骨芽細胞におけるストレス誘導性microRNAの解析, 平成28年度公益社団法人日本補綴歯科学会九州支部,中国・四国支部合同学術大会, Sep. 2016.
39.	Gantumur Chimeddulam, Keisuke Nishigawa, 葉山莉香, Toyoko Tajima, Yoritoki Tomotake, Yoshihito Naitou, Tetsuo Ichikawa and Yoshizo Matsuka : 歯科インプラント周囲の骨吸収に関する臨床疫学研究, The Journal of the Japan Prosthodontic Society, Jul. 2016.
40.	Toyoko Tajima, Yoshihito Naitou, Yoshizo Matsuka, Kazuo Okura and Yoritoki Tomotake : 自家骨移植による下顎骨再建症例にリーゲル機構を付与した患者可綴式上部構造を用いて咬合機能を回復した 2 症例, Journal of Japanese Society of Oral Implantology, Sep. 2015.
41.	Yuki Iwawaki, 檜垣宜明, Takaharu Goto, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : microRNA -mirR-494-3p -, 平成27年度社団法人日本補綴歯科学会第124回学術大会, May 2015.
42.	Yoshihito Naitou, Ryo Jinbo, Toyoko Tajima, Tetsuo Ichikawa and Yoritoki Tomotake : ウサギ頭蓋骨におけるシンバスタチン封入徐放型マイクロスフィアの骨形成促進効果, 日本口腔インプラント学会中国・四国支部学術大会, Nov. 2014.
43.	岩脇有軌, Noriko Mizusawa, Takeo Iwata, Shinji Ono, Yoritoki Tomotake, Tetsuo Ichikawa and Katsuhiko Yoshimoto : メカニカルストレス応答性 miR-494-3p による FGFR2 発現の抑制, 第56回歯科基礎医学会学術大会・総会福岡, Sep. 2014.
44.	Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : 周期的低周波磁場が骨芽細胞の分化に与える影響, 第44回公益社団法人日本口腔インプラント学会学術大会, Sep. 2014.
45.	岩脇有軌, 水澤典子, Hideki Suitou, Takaharu Goto, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : メカニカルストレスに応答するmiR-494-3pはFGFR2の発現を抑制する, 公益社団法人日本補綴歯科学会第123回学術大会, May 2014.
46.	Yuichi Ishida, Takaharu Goto, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : フルートの演奏を仕事とする患者に対してインプラント治療を行った1 症例, 第33回公益社団法人日本口腔インプラント学会中国・四国支部総会学術大会, Nov. 2013.
47.	岩脇有軌, Takaharu Goto, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : メカニカルストレスに応答するmicroRNAの同定, 第43回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2013.
48.	檜垣宜明, Takaharu Goto, Yuichi Ishida, Yoritoki Tomotake, Kan Nagao, Tetsuo Ichikawa and 多田望 : 口腔内刺激が脳機能活動に与える影響, 平成25年度公益社団法人日本補綴歯科学会中国・四国支部学術大会, Aug. 2013.
49.	岩脇有軌, Noriko Mizusawa, Takeo Iwata, 小野信二, Yoritoki Tomotake, Tetsuo Ichikawa and Katsuhiko Yoshimoto : 機械的刺激応答性miRNAの同定, 第5回日本RNAi研究会広島, Aug. 2013.
50.	Hideki Suito, 岩脇有軌, Yuichi Ishida, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : 疑似体液中でのチタン溶出への影響を及ぼす因子の検討, 公益社団法人日本補綴歯科学会設立80周年記念第122回学術大会, May 2013.
51.	水頭英樹, 岩脇有軌, Yuichi Ishida, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : 疑似体液中でのチタン溶出への影響を及ぼす因子の検討, 公益社団法人日本補綴歯科学会設立80周年記念第122回学術大会, May 2013.
52.	Hideki Suito, Takaharu Goto, Yuichi Ishida, Yoritoki Tomotake and Tetsuo Ichikawa : 磁性アタッチメントを応用したミニインプラントオーバーデンチャーの負担圧分布と義歯の動揺解析, 第32回日本口腔インプラント学会中国・四国支部学術大会, Nov. 2012.
53.	Yoritoki Tomotake, 藤本直樹, 山田幸夫, 富永賢 and Tetsuo Ichikawa : 歯冠内スライドアタッチメントによる分割式上部構造を用いた症例考察．, 日本口腔インプラント学会中国四国支部学術大会, Nov. 2012.
54.	Yuichi Ishida, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント暫間上部構造による最終上部構造の推定．, 日本歯科医学会総会, Nov. 2012.
55.	Takaharu Goto, Kan Nagao, Yuichi Ishida, Toshiya Kashiwabara, Yoritoki Tomotake and Tetsuo Ichikawa : インプラントオーバーデンチャー床下組織の負担分布と義歯の動揺に関する研究, 第22回日本歯科医学会総会, Nov. 2012.
56.	Takaharu Goto, Yuichi Ishida, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : 磁性アタッチメントを歯冠内・歯冠外アタッチメントとして用いた長期経過症例について, 第22回日本磁気歯科学会学術大会, Nov. 2012.
57.	水頭英樹, Takaharu Goto, Yoritoki Tomotake, Tetsuo Ichikawa and 西村良一 : チタンの溶出に影響を及ぼす因子の検討, Journal of Japanese Society of Oral Implantology, Vol.25, 292, Sep. 2012.
58.	岩脇有軌, 西中英伸, Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント上部構造における主機能部位と補綴学的問題の関連について, Journal of Japanese Society of Oral Implantology, Vol.25, 295, Sep. 2012.
59.	Hideki Suito, Takaharu Goto, Yoritoki Tomotake, Tetsuo Ichikawa and 西村良一 : チタンの溶出に影響を及ぼす因子の検討, 第42回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2012.
60.	Takaharu Goto, Yuichi Ishida, Yoritoki Tomotake, Kan Nagao, Tetsuo Ichikawa and 宮本雅司 : 義歯の動揺計測からインプラントオーバーデンチャー床下組織の負担分布を推定できるか, 社団法人日本補綴歯科学会第121回学術大会, May 2012.
61.	Megumi Watanabe, Yoshihito Naitou, Yoritoki Tomotake and Tetsuo Ichikawa : Analysis of G-protein in Dendritic Cells in Nickel Allergy Mouse Model, 日本補綴歯科学会第121回学術大会, May 2012.
62.	Hideki Suito, 岩脇有機, Yoshihito Naitou, Daisuke Nagao, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : セメントおよびスクリュー固定を併用するインプラント-上部構造に関する考察, Annals of Japan Prosthodontic Society, Vol.4, No.1, Jan. 2012.
63.	岩脇有軌, Yuichi Ishida, Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント治療に対する認識 -学生・研修医へのアンケート調査-, 第31回日本口腔インプラント学会中国四国支部総会学術大会, Oct. 2011.
64.	Daisuke Nagao, Yoshihito Naitou, Hideki Suito, Yoritoki Tomotake and Tetsuo Ichikawa : インプラント周囲溝滲出液中におけるタンパクの定量的評価, 第41回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2011.
65.	Yuichi Ishida, Hideki Suito, Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : Estimation of prosthetic complications occurred in the superstructure by the provisional restoration:veneer fractures and interproximal contact loss, 第41回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2011.
66.	T Goto, H Nishinaka, Toshiya Kashiwabara, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : Significance of the Main Occluding Area in Implant Treatment, 社団法人日本補綴歯科学会第120回記念学術大会, May 2011.
67.	Yuichi Ishida, 後藤崇晴, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : 臼歯遊離端欠損症例におけるインプラント上部構造に関する臨床調査, 第30回日本口腔インプラント学会中国・四国支部総会・学術大会, Nov. 2010.
68.	Yoritoki Tomotake, 木村英一郎, 河上雄之介, 加藤智彦, 陶山ケイ子, 岸祐治, 山根進 and Tetsuo Ichikawa : インプラント治療への患者と歯科医の疑問に関するアンケート調査, 第40回日本口腔インプラント学会・学術大会, Sep. 2010.
69.	後藤崇晴, Yuichi Ishida, Yoritoki Tomotake, Kan Nagao and Tetsuo Ichikawa : アタッチメントの違いがインプラントオーバーデンチャー床下組織の負担圧に及ぼす影響 -義歯の剛性の影響-, 第40回日本口腔インプラント学会・学術大会, Sep. 2010.
70.	奥津達, 吉田有里, Daisuke Nagao, 石田雄一, Yutaka Sato, Yoritoki Tomotake and Tetsuo Ichikawa : Response to Intermittent Compressive Stress in MC3T3-E1 Cells, 日本口腔インプラント学会・第38回学術大会抄録, Vol.21, 135, Sep. 2008. (Summary) Ⅰ目的:力学的ストレスに対する周囲骨組織の応答を検討することは, インプラント治療において重要である. 持続的圧縮ストレスによる骨芽細胞の遺伝子発現の変化を検討している研究はこれまでに多数認められ, 我々も以前に持続的圧縮ストレスをMC3T 3-E1細胞に加えた場合, インテグリンを介してHeat shock prote in 25 (Hsp25) の発現が上昇することを見出した. しかし, 間欠的な圧縮ストレスと持続的な圧縮ストレスを比較した報告は少ない. そこで今回, 骨芽細胞様細胞株MC3T3-E1に圧縮力を加え, その圧縮頻度及び時間の相違による応答を検討した. Ⅱ材料及び方法:マウス骨芽細胞様細胞株MC3T3-E1細胞をコラーゲンコーティングプレートに播種, コンフルエントに達するまで培養後, 自作の細胞圧縮装置によって間欠的および持続的な圧縮力 (約320 Pa) を加えた. 間欠的圧縮力は等時間間隔で圧縮, 非圧縮を24時間繰り返す設定とした. その後, RNAを採取し, リアルタイムRT-PCRにて特定遺伝子の発現量を検討した. 対象遺伝子には, ストレスのマーカーとして知られているCyclooxygen ase-2 (Cox-2) 及びHeat shock protein 25 (Hsp25) を, また骨のリモデリングの指標としてOsteoprotegerin (Opg) を, さらに内部標準には, TATA box binding protein (Tbp) を採用した. Ⅲ結果:Cox-2, Hsp25は24時間の持続的な圧縮ストレスにより発現量の上昇が認められた. また, 短時間の間欠的圧縮力 (8分以下の圧縮と非圧縮の繰り返し) を加えた24時間刺激後のCox-2, Hsp25遺伝子発現は非圧縮群に比較して著明な変化は認められなかった. Opg遺伝子発現に関しては, 非圧縮群と, 持続的及び短時間の間欠的圧縮群との間に有意差は認められなかった. Ⅳ考察及び結論:以上の結果により, 骨芽細胞様細胞MC3T3-E1 においては, Cox-2, Hsp25発現に関しては持続的な圧縮ストレスの影響が大きく, 短時間の間欠的な圧縮ストレスでは遺伝子発現応答に影響が少ないことが示された. また, Opgに関しては持続的, 短時間の間欠的圧縮ストレスとも遺伝子発現応答に影響が少ないことが示された. 今後, インプラントに加わる時間的要因を遺伝子レベルで明らかにすることによって, インプラント治療のリスクファクターを明確にできると考える.
71.	石田雄一, Yutaka Sato, 吉田有里, Daisuke Nagao, Yoritoki Tomotake and Tetsuo Ichikawa : Development of the implant positioning system using motion control sensor, Sep. 2007. (Summary) Ⅰ目的:我々は1993年にPilot hole preparationという埋入方法を，2002年にrapid prototypingを用いた方法をいち早く報告している．その後，CT画像からコンピュータ上で適正なインプラント埋入位置をシミュレートし，その結果を反映した外科用テンプレートにより，安全で精度の高いインプラント埋入する方法が一般化しつつある．今回，我々は3次元の全方位姿勢角度の計測可能センサを用いたインプラント埋入システムを考案したので，そのシステムの概要と有用性について報告する．Ⅱ方法:本システムは，アモルファスワイヤの磁気インダクタンス効果を利用したモーションコントロールセンサ(AMI，愛知製鋼)部と検出部からなる．測定対象の基本姿勢をセンサで計測し，この座標系に対する測定対象の3次元的な姿勢角度をリアルタイムでモニターすることができる．現時点でのシステムの角度検出の精度と，模型を使用して従来の外科用テンプレートと比較した場合の埋入精度について調査した．Ⅲ結果:時間的変動は0.46度，空間的精度は2.25度であった．埋入精度は，外科用テンプレートと比較した場合に，若干劣った．しかし，テンプレートの動揺に気を遣う必要はなく，操作性では優れていた．Ⅳ考察および結論:センサ精度としては実用化の範囲に近づいている．本システムは，インプラント埋入において有用なしステムになりうることが示唆された．

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Development of functional membrane for dental implant treatment (Project/Area Number: 16K11598 )
Application of porous titanium using moldless process for prosthesis (Project/Area Number: 15K11196 )
The elucidation of miRNAs in response to stress stimuli and its secretion into an oral cavity (Project/Area Number: 25670822 )
The development of effective denture stabilizer for the oral care by using the temperature-responsive polymer (Project/Area Number: 24592958 )
Response of irradiated tissue supporting implant prosthesis under the compressing force. (Project/Area Number: 21592497 )
Studies on Oral Implant Surgery Support System towards Patient-Centered Health Care (Project/Area Number: 18300170 )
インプラント周囲炎に対する周囲骨再生療法の開発 (Project/Area Number: 17659611 )
The development of taylor-made materials with biomedical function. (Project/Area Number: 17390521 )
埋入即時負荷インプラント治療の適正と治療設計の基準についての検討 (Project/Area Number: 16791193 )
Effect of physical factors on osseointegration (Project/Area Number: 14370637 )
インプラント治療における周囲軟組織増生法(バルーンエクステンション法)の開発 (Project/Area Number: 13771170 )
Quality assessment of bone and surface modification of dental implant (Project/Area Number: 12470421 )
インプラントの振動,変位特性からみた適切なインプラント骨界面と上部構造材料の推定 (Project/Area Number: 11771223 )
The influence of the biofilm in the oral cavity to the dental implants (Project/Area Number: 11671937 )
義歯用硬質レジン歯と即時重合レジンの結合強さの向上に関する研究 (Project/Area Number: 08771795 )
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Associate Professor : Tomotake, Yoritoki

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)