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Tokushima University > Institute of Advanced Medical Sciences > Institute for Enzyme Research >
Tokushima University > Graduate School of Medical Sciences > Medical Science > 酵素・プロテオミクス医学講座 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1803002 生活習慣病によって脂肪組織と血管壁に生じる慢性炎症の機序の解明と新規治療法の開発 >
Tokushima University > Research Clusters > Research Clusters (Prioritized) > 1702005 難病の克服を目指した免疫学研究の拠点形成 >
Tokushima University > Research Clusters > Research Clusters (Registered) > 1804001 慢性炎症を分子基盤とした肥満・糖尿病および多臓器合併症の病態解明と治療法開発 >
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Research Activity

Field of Study

Immunology, Internal Medicine, Genetics Engineering

Subject of Study

Studies on the pathogenesis of autoimmunity

Book / Paper

Book:

1. Minoru Matsumoto, Rodrigues M. Pedro, Sousa Laura, Koichi Tsuneyama, Mitsuru Matsumoto and Alves L. Nuno :
The Ins and Outs of Thymic Epithelial Cell Differentiation and Function,
Springer, Apr. 2019.
2. Mitsuru Matsumoto :
Control of chronic inflammation through elucidation of organ-specific autoimmune disease mechanisms,
Springer, Japan, Mar. 2016.
3. Mitsuru Matsumoto :
内科学,
西村書店, Tokyo, Jul. 2012.
4. Mitsuru Matsumoto :
遺伝子改変自己免疫モデルーAIRE欠損マウス,
エル・アイ・シー, Tokyo, Jun. 2011.
5. Mitsuru Matsumoto :
生物学事典,
Tokyo Kagaku Dozin C., Ltd., Tokyo, Dec. 2010.

Academic Paper (Judged Full Paper):

1. Shinya Hatano, Tun Xin, Naoto Noguchi, Yue Dan, Hisakata Yamada, Sun Xun, Mitsuru Matsumoto and Yasunobu Yoshikai :
Development of a new monoclonal antibody specific to mouse Vγ6 chain,
Life Science Alliance, Vol.2, No.3, 1-12, 2019.
(DOI: 10.26508/lsa.201900363,   PubMed: 31064767,   Elsevier: Scopus)
2. Wang Jianwei, Miho Sekai, Takeshi Matsui, Yosuke Fujii, Mitsuru Matsumoto, Osamu Takeuchi, Nagahiro Minato and Yoko Hamazaki :
Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus,
International Immunology, Vol.31, No.3, 127-139, 2019.
(DOI: 10.1093/intimm/dxy073,   PubMed: 30534943,   Elsevier: Scopus)
3. Junko Morimoto, Yumiko Nishikawa, Takumi Kakimoto, Kohei Furutani, Naoki Kihara, Minoru Matsumoto, Koichi Tsuneyama, Yuko Kozono, Haruo Kozono, Katsuto Hozumi, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto :
Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G.,
The Journal of Immunology, Vol.201, No.11, 3244-3257, 2018.
(DOI: 10.4049/jimmunol.1800950,   PubMed: 30389776)
4. Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Minoru Matsumoto, Hiroshi Kawano, Yasuhiko Nishioka, Hisanori Uehara, Keisuke Izumi, Koichi Tsuneyama, Il-mi Okazaki, Taku Okazaki, Kazuyoshi Hosomichi, Ayako Shiraki, Makoto Shibutani, Kunitoshi Mitsumori and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).,
Journal of Autoimmunity, Vol.86, 75-92, 2018.
(Tokushima University Institutional Repository: 112347,   DOI: 10.1016/j.jaut.2017.09.006,   PubMed: 28931462)
5. Yasuhiro Mouri, Yoshihiro Ueda, Tomoyoshi Yamano, Minoru Matsumoto, Koichi Tsuneyama, Tatsuo Kinashi and Mitsuru Matsumoto :
Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen,
The Journal of Immunology, Vol.199, No.12, 3959-3971, 2017.
(DOI: 10.4049/jimmunol.1700892,   PubMed: 29101311,   Elsevier: Scopus)
6. Nobuko Akiyama, Nobukazu Takizawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Miho Shinzawa, Riko Yoshinaga, Masaaki Kurihara, Yosuke Demise, Hisataka Yasuda, Shintaro Yagi, Guoying Wu, Mitsuru Matsumoto, Reiko Sakamoto, Nobuaki Yoshida, Josef M. Penninger, Yasuhiro Kobayashi, Jun-ichiro Inoue and Taishin Akiyama :
Identi cation of embryonic precursor cells that di erentiate into thymic epithelial cells expressing autoimmune regulator,
The Journal of Experimental Medicine, Vol.213, No.8, 1441-1458, 2016.
(Tokushima University Institutional Repository: 112343,   DOI: 10.1084/jem.20151780)
7. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Yasuhiko Nishioka and Mitsuru Matsumoto :
Aire expression is inherent to most medullary thymic epithelial cells during their differentiation program.,
The Journal of Immunology, Vol.195, No.11, 5149-5158, 2015.
(DOI: 10.4049/jimmunol.1501000,   PubMed: 26503950)
8. Hitoshi Nishijima, Satsuki Kitano, Hitoshi Miyachi, Junko Morimoto, Hiroshi Kawano, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Kiyoshi Masuda, Issei Imoto, Koichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla.,
The Journal of Immunology, Vol.195, No.10, 4641-4649, 2015.
(DOI: 10.4049/jimmunol.1501026,   PubMed: 26453754,   Elsevier: Scopus)
9. Yasuhiro Mouri, Hitoshi Nishijima, Hiroshi Kawano, Fumiko Hirota, Nobuo Sakaguchi, Junko Morimoto and Mitsuru Matsumoto :
NF-κB-Inducing Kinase in Thymic Stroma Establishes Central Tolerance by Orchestrating Cross-Talk with Not Only Thymocytes but Also Dendritic Cells.,
The Journal of Immunology, Vol.193, No.9, 4356-4367, 2014.
(DOI: 10.4049/jimmunol.1400389,   PubMed: 25261487)
10. Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Joerg Hans Fehring, Yasuhiro Mouri and Mitsuru Matsumoto :
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.,
The Journal of Immunology, Vol.192, No.6, 2585-2592, 2014.
(DOI: 10.4049/jimmunol.1302786,   PubMed: 24516201,   Elsevier: Scopus)
11. Chikako Odaka, Mathias Hauri-Hohl, Kazuya Takizawa, Yumiko Nishikawa, Masashi Yano, Mitsuru Matsumoto, Richard Boyd and George A. Hollander :
TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice,
International Immunology, Vol.25, No.11, 633-642, 2013.
(DOI: 10.1093/intimm/dxt026,   PubMed: 23929912)
12. Sumiko Yoshida, Ken-ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo-Ueda, Ryoko Uemoto, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yasuhiro Mouri, Matomo Sakari, Takahiro Matsumoto, Ken-ichi Takeyama, Masashi Akaike, Mitsuru Matsumoto, Masataka Sata, Kenneth Walsh, Shigeaki Kato and Toshio Matsumoto :
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.,
Circulation, Vol.128, No.1, 60-71, 2013.
(DOI: 10.1161/CIRCULATIONAHA.113.001533,   PubMed: 23723256)
13. Michio Nakaya, Mitsuru Tajima, Hidetaka Kosako, Takeo Nakaya, Akiko Hashimoto, Kenji Watari, Hiroaki Nishihara, Mina Ohba, Shiori Komiya, Naoki Tani, Motohiro Nishida, Hisaaki Taniguchi, Yoji Sato, Mitsuru Matsumoto, Makoto Tsuda, Masahiko Kuroda, Kazuhide Inoue and Hitoshi Kurose :
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.,
Nature Communications, Vol.4, No.1532, 2013.
(DOI: 10.1038/ncomms2540,   PubMed: 23443560,   Elsevier: Scopus)
14. Ayuko Sakane, Ahmed Alamir Mahmoud Abdallah, Kiyoshi Nakano, Kazufumi Honda, Wataru Ikeda, Yumiko Nishikawa, Mitsuru Matsumoto, Natsuki Matsushita, Toshio Kitamura and Takuya Sasaki :
Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development.,
The Journal of Biological Chemistry, Vol.287, No.51, 42455-42468, 2012.
(DOI: 10.1074/jbc.M112.383653,   PubMed: 23100251)
15. Yoshihiro Ueda, Koko Katagiri, Takashi Tomiyama, Kaneki Yasuda, Katsuyoshi Habiro, Tomoya Katakai, Susumu Ikehara, Mitsuru Matsumoto and Tatsuo Kinashi :
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus,
Nature Communications, Vol.3, 1098, 2012.
(DOI: 10.1038/ncomms2105,   PubMed: 23033074)
16. Yukiko Kuroda, Wataru Sako, Satoshi Goto, Tomoyo Sawada, Daisuke Uchida, Yuishin Izumi, Tetsuya Takahashi, Noriko Kagawa, Masayasu Matsumoto, Mitsuru Matsumoto, Ryosuke Takahashi, Ryuji Kaji and Takao Mitsui :
Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential,
Human Molecular Genetics, Vol.21, No.5, 991-1003, 2012.
(DOI: 10.1093/hmg/ddr530,   PubMed: 22082830,   Elsevier: Scopus)
17. Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida and Kensuke Miyake :
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking,
Immunity, Vol.35, No.1, 69-81, 2011.
(DOI: 10.1016/j.immuni.2011.05.010,   PubMed: 21683627)
18. Yasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Fumiko Hirota, Yumiko Nishikawa, Takuro Nii, Hiroshi Kiyonari, Takaya Abe, Hisanori Uehara, Keisuke Izumi, Koji Tamada, Lieping Chen, Josef M. Penninger, Jun-ichiro Inoue, Taishin Akiyama and Mitsuru Matsumoto :
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma,
The Journal of Immunology, Vol.186, No.9, 5047-5057, 2011.
(DOI: 10.4049/jimmunol.1003533,   PubMed: 21441458)
19. Naoko Wada, Koji Nishifuji, Taketo Yamada, Jun Kudoh, Nobuyoshi Shimizu, Mitsuru Matsumoto, Leena Peltonen, Seiho Nagafuchi and Masayuki Amagai :
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance,
The Journal of Investigative Dermatology, Vol.131, No.2, 410-417, 2011.
(DOI: 10.1038/jid.2010.330,   PubMed: 21048786,   Elsevier: Scopus)
20. Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Kitajima Hiroyuki, Miyazaki Jun-ichi, Kawamoto Hiroshi, Yasuhiro Mouri and Mitsuru Matsumoto :
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation,
The Journal of Experimental Medicine, Vol.207, No.5, 963-971, 2010.
(DOI: 10.1084/jem.20092144,   PubMed: 20404099)
21. Yuka Tomoe, Hiroko Segawa, Kazuyo Shiozawa, Ichiro Kaneko, Rieko Tominaga, Etsuyo Hanabusa, Fumito Aranami, Junya Furutani, Shoji Kuwahara, Sawako Tatsumi, Mitsuru Matsumoto, Mikiko Ito and Ken-ichi Miyamoto :
Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice,
American Journal of Physiology, Renal Physiology, Vol.298, No.6, F1341-F1350, 2010.
(DOI: 10.1152/ajprenal.00375.2009,   PubMed: 20357029)
22. Kimi Yamakoshi, Akiko Takahashi, Fumiko Hirota, Rika Nakayama, Naozumi Ishimaru, Yoshiaki Kubo, J. David Mann, Masako Ohmura, Atsushi Hirao, Hideyuki Saya, Seiji Arase, Yoshio Hayashi, Kazuki Nakao, Mitsuru Matsumoto, Naoko Ohtani and Eiji Hara :
Real-time in vivo imaging of p16Ink4a reveals cross-talk with p53,
The Journal of Cell Biology, Vol.186, No.3, 393-407, 2009.
(DOI: 10.1083/jcb.200904105,   PubMed: 19667129)
23. Hiroko Segawa, Akemi Onitsuka, Junya Furutani, Ichiro Kaneko, Fumito Aranami, Natsuki Matsumoto, Yuka Tomoe, Masashi Kuwahata, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka and Ken-ichi Miyamoto :
Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development,
American Journal of Physiology, Renal Physiology, Vol.297, No.3, F671-678, 2009.
(DOI: 10.1152/ajprenal.00156.2009,   PubMed: 19570882)
24. Hiroko Segawa, Akemi Onitsuka, Masashi Kuwahata, Etsuyo Hanabusa, Junya Furutani, Ichiro Kaneko, Yuka Tomoe, Fumito Aranami, Natsuki Matsumoto, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka and Ken-ichi Miyamoto :
Type IIc sodium dependent phosphate transporter regulates calcium metabolism,
Journal of the American Society of Nephrology, Vol.20, No.1, 104-113, 2009.
(DOI: 10.1681/ASN.2008020177,   PubMed: 19056871,   Elsevier: Scopus)
25. Masashi Yano, Noriyuki Kuroda, Hongwei Han, Makiko Meguro-Horike, Yumiko Nishikawa, Hiroshi Kiyonari, Kentaro Maemura, Yuchio Yanagawa, Kunihiko Obata, Satoru Takahashi, Tomokatsu Ikawa, Rumi Satoh, Hiroshi Kawamoto, Yasuhiro Mouri and Mitsuru Matsumoto :
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.,
The Journal of Experimental Medicine, Vol.205, No.12, 2827-2838, 2008.
(DOI: 10.1084/jem.20080046,   PubMed: 19015306)
26. Taishin Akiyama, Yusuke Shimo, Hiromi Yanai, Junwen Qin, Daisuke Ohshima, Yuya Maruyama, Yukiko Asaumi, Juli Kitazawa, Hiroshi Takayanagi, Josef Penninger, Mitsuru Matsumoto, Takeshi Nitta, Yousuke Takahama and Jun-ichiro Inoue :
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.,
Immunity, Vol.29, No.3, 423-437, 2008.
(DOI: 10.1016/j.immuni.2008.06.015,   PubMed: 18799149)
27. Yu Hikosaka, Takeshi Nitta, Izumi Ohigashi, Kouta Yano, Naozumi Ishimaru, Yoshio Hayashi, Mitsuru Matsumoto, Koichi Matsuo, Josef M Penninger, Hiroshi Takayanagi, Yoshifumi Yokota, Hisakata Yamada, Yasunobu Yoshikai, Jun-ichiro Inoue, Taishin Akiyama and Yousuke Takahama :
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.,
Immunity, Vol.29, No.3, 438-450, 2008.
(DOI: 10.1016/j.immuni.2008.06.018,   PubMed: 18799150)
28. Mitsuru Matsumoto, Yiqing Zhou, Shinji Matsuo, Hideki Nakanishi, Kenji Hirose, Hajimu Oura, Seiji Arase, Akemi Ishida-Yamamoto, Yoshimi Bando, Keisuke Izumi, Hiroshi Kiyonari, Naoko Oshima, Rika Nakayama, Akemi Matsushima, Fumiko Hirota, Yasuhiro Mouri, Noriyuki Kuroda, Shigetoshi Sano and David D. Chaplin :
Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology,
Proceedings of the National Academy of Sciences of the United States of America, Vol.105, No.18, 6720-6724, 2008.
(DOI: 10.1073/pnas.0709345105,   PubMed: 18436651)
29. Masashi Nakatani, Yuka Takehara, Hiromu Sugino, Mitsuru Matsumoto, Osamu Hashimoto, Yoshihisa Hasegawa, Tatsuya Murakami, Akiyoshi Uezumi, Shin'ichi Takeda, Sumihare Noji, Yoshihide Sunada and Kunihiro Tsuchida :
Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice.,
The FASEB journal, Vol.22, No.2, 477-487, 2008.
(DOI: 10.1096/fj.07-8673com,   PubMed: 17893249)
30. Junwen Qin, Hiroyasu Konno, Daisuke Ohshima, Hiromi Yanai, Hidehiko Motegi, Yusuke Shimo, Fumiko Hirota, Mitsuru Matsumoto, Satoshi Takaki, Jun-ichiro Inoue and Taishin Akiyama :
Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs,
The Journal of Immunology, Vol.179, No.10, 6799-6807, 2007.
(PubMed: 17982070)
31. Naoko Ohtani, Yuko Imamura, Kimi Yamakoshi, Fumiko Hirota, Rika Nakayama, Yoshiaki Kubo, Naozumi Ishimaru, Akiko Takahashi, Atsushi Hirao, Takatsune Shimizu, David J. Mann, Hideyuki Saya, Yoshio Hayashi, Seiji Arase, Mitsuru Matsumoto, Nakao Kazuki and Eiji Hara :
Visualizing the dynamics of p21 (Wafl/Cip1)cyclin-dependent kinase inhibitor expression in living animals.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.104, No.38, 15034-15039, 2007.
(DOI: 10.1073/pnas.0706949104,   PubMed: 17848507)
32. Toshiyuki Obata, Ichiro Yokota, Kazuhiro Yokoyama, Eiji Okamoto, Yoshiko Kanezaki, Yoshinori Tanaka, Hiroshi Maegawa, Kiyoshi Teshigawara, Fumiko Hirota, Tomoyuki Yuasa, Kazuhiro Kishi, Atsushi Hattori, Seiichi Hashida, Kazuhiko Masuda, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus.,
Diabetes, Vol.56, No.8, 2028-2035, 2007.
(DOI: 10.2337/db07-0394,   PubMed: 17563065)
33. Yoko Hamazaki, Harumi Fujita, Takashi Kobayashi, Yongwon Choi, Hamish S Scott, Mitsuru Matsumoto and Nagahiro Minato :
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin,
Nature Immunology, Vol.8, No.3, 304-311, 2007.
(DOI: 10.1038/ni1438,   PubMed: 17277780)
34. Shino Niki, Kiyotaka Oshikawa, Yasuhiro Mouri, Fumiko Hirota, Akemi Matsushima, Masashi Yano, Hongwei Han, Yoshimi Bando, Keisuke Izumi, Masaki Matsumoto, Keiichi I. Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto :
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice,
The Journal of Clinical Investigation, Vol.116, No.5, 1292-1301, 2006.
(DOI: 10.1172/JCI26971,   PubMed: 16628255)
35. Dan Kinoshita, Fumiko Hirota, Tsuneyasu Kaisho, Michiyuki Kasai, Keisuke Izumi, Yoshimi Bando, Yasuhiro Mouri, Akemi Matsushima, Shino Niki, Hongwei Han, Kiyotaka Oshikawa, Noriyuki Kuroda, Masahiko Maegawa, Minoru Irahara, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto :
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.,
The Journal of Immunology, Vol.176, No.7, 3995-4002, 2006.
(PubMed: 16547234,   Elsevier: Scopus)
36. Katsuaki Hoshino, Takahiro Sugiyama, Mitsuru Matsumoto, Takashi Tanaka, Masuyoshi Saito, Hiroaki Hemmi, Osamu Ohara, Shizuo Akira and Tsuneyasu Kaisho :
IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9,
Nature, Vol.440, No.7086, 949-953, 2006.
(DOI: 10.1038/nature04641,   PubMed: 16612387)
37. Yoshinori Nagai, Toshihiko Kobayashi, Yuji Motoi, Kohtaroh Ishiguro, Sachiko Akashi, Shin-ichiroh Saitoh, Yutaka Kusumoto, Tsuneyasu Kaisho, Shizuo Akira, Mitsuru Matsumoto, Kiyoshi Takatsu and Kensuke Miyake :
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes,
The Journal of Immunology, Vol.174, No.11, 7043-7049, 2005.
(PubMed: 15905547)
38. Taishin Akiyam, Shiori Maeda, Sayaka Yamane, Kaori Ogino, Michiyuki Kasai, Fumiko Kajiura, Mitsuru Matsumoto and Jun-ichiro Inoue :
Dependence of self-tolerance on TRAF6-directed development of thymic stroma,
Science, Vol.308, No.5719, 248-251, 2005.
(DOI: 10.1126/science.1105677,   PubMed: 15705807)
39. Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura, Shimon Sakaguchi, Tomoo Ueno, Yousuke Takahama, Daisuke Uchida, Shijie Sun, Fumiko Kajiura, Yasuhiro Mouri, Hongwei Han, Akemi Matsushima, Gen Yamada and Mitsuru Matsumoto :
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice,
The Journal of Immunology, Vol.174, No.4, 1862-1870, 2005.
(DOI: 10.3410/f.1024264.287833,   PubMed: 15699112)
40. Tomoyuki Yuasa, Rei Kakuhata, Kazuhiro Kishi, Toshiyuki Obata, Yasuo Shinohara, Yoshimi Bando, Keisuke Izumi, Fumiko Kajiura, Mitsuru Matsumoto and Yousuke Ebina :
Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels,
Diabetes, Vol.53, No.11, 2776-2786, 2004.
(DOI: 10.2337/diabetes.53.11.2776,   PubMed: 15504957)
41. Hiroko Akiyoshi, Shigetsugu Hatakeyama, Jukka Pitkanen, Yasuhiro Mouri, Vassilis Doucas, Jun Kudoh, Kyoko Tsurugaya, Daisuke Uchida, Akemi Matsushima, Kiyotaka Oshikawa, Keiichi I. Nakayama, Nobuyoshi Shimizu, Part Peterson and Mitsuru Matsumoto :
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner,
The Journal of Biological Chemistry, Vol.279, No.32, 33984-33991, 2004.
(DOI: 10.1074/jbc.M400702200,   PubMed: 15150263)
42. Takashi Sakai, Li Liu, Xichuan Teng, Rika Mukai-Sakai, Hidenori Shimada, Ryuji Kaji, Tasuku Mitani, Mitsuru Matsumoto, Kazunori Toida, Kazunori Ishimura, Yuji Shishido, Tak W. Mak and Kiyoshi Fukui :
Nucling Recruits Apaf-1/Pro-caspase-9 Complex for the Induction of Stress-Induced Apoptosis,
The Journal of Biological Chemistry, Vol.279, No.39, 41131-41140, 2004.
(DOI: 10.1074/jbc.M402902200,   PubMed: 15271982,   CiNii: 80016958432)
43. Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto and Yousuke Ebina :
KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-Negative Form of Human Insulin Receptor have Glucose Intolerance but not Diabetes,
Endocrine Journal, Vol.51, No.2, 133-144, 2004.
(DOI: 10.1507/endocrj.51.133,   PubMed: 15118262)
44. Fumiko Kajiura, Shijie Sun, Takashi Nomura, Keisuke Izumi, Tomoo Ueno, Yoshimi Bando, Noriyuki Kuroda, Hongwei Han, Yi Li, Akemi Matsushima, Yousuke Takahama, Shimon Sakaguchi, Tasuku Mitani and Mitsuru Matsumoto :
NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner,
The Journal of Immunology, Vol.172, No.4, 2067-2075, 2004.
(PubMed: 14764671)
45. Daisuke Uchida, Shigetsugu Hatakeyama, Akemi Matsushima, Hongwei Han, Satoshi Ishido, Hak Hotta, Jun Kudoh, Nobuyuki Shimizu, Vassilis Doucas, Keiichi I Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto :
AIRE functions as an E3 ubiquitin ligase,
The Journal of Experimental Medicine, Vol.199, No.2, 166-172, 2004.
(DOI: 10.1084/jem.20031291,   PubMed: 14734522)
46. Asako Minami, Masanori Iseki, Kazuhiro Kishi, Miao Wang, Makoto Ogura, Noboru Furukawa, Sanae Hayashi, Mizuki Yamada, Toshiyuki Obata, Yukari Takeshita, Yutaka Nakaya, Yoshimi Bando, Keisuke Izumi, Shonna A Moodie, Fumiko Kajiura, Mitsuru Matsumoto, Kiyoshi Takatsu, Satoshi Takaki and Yousuke Ebina :
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice,
Diabetes, Vol.52, No.11, 2657-2665, 2003.
(DOI: 10.2337/diabetes.52.11.2657,   PubMed: 14578283)
47. Mitsuru Matsumoto, Takuji Yamada, Steven K. Yoshinaga, Tom Boone, Tom Horan, Shigeru Fujita, Yi Li and Tasuku Mitani :
Essential role of NF-kappaB-inducing kinase in T cell activation through the TCR/CD3 pathway,
The Journal of Immunology, Vol.169, No.3, 1151-1158, 2002.
(PubMed: 12133934)
48. Akemi Matsushima, Tsuneyasu Kaisho, Paul D. Rennert, Hiroyasu Nakano, Kyoko Kurosawa, Daisuke Uchida, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto :
Essential role of NF-kappaB-inducing kinase and IkappaB-kinase alpha in NF-kappaB activation through lymphotoxin-beta receptor, but not through TNF receptor-I,
The Journal of Experimental Medicine, Vol.193, No.5, 631-636, 2001.
(DOI: 10.1084/jem.193.5.631,   PubMed: 11238593,   Elsevier: Scopus)
49. Masaya Uwai, Yasuhito Terui, Yuji Mishima, Hiroshi Tomizuka, Masayuki Ikeda, Takehito Itoh, Masaki Mori, Masuzu Ueda, Rie Inoue, Muneo Yamada, Hirotoshi Hayasawa, Takahiko Horiuchi, Yoshiyuki Niho, Mitsuru Matsumoto, Yukihito Ishizaka, Kazuma Ikeda, Keiya Ozawa and Kiyohiko Hatake :
A new apoptotic pathway for the complement factor B-derived fragment Bb,
Journal of Cellular Physiology, Vol.185, No.2, 280-292, 2000.
50. Takuji Yamada, Tasuku Mitani, Kazuko YORITA, Daisuke Uchida, Akemi Matsushima, Kikue Iwamasa, Shigeru Fujita and Mitsuru Matsumoto :
Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-kappaB-Inducing Kinase,
The Journal of Immunology, Vol.165, No.2, 804-812, 2000.
(PubMed: 10878354,   Elsevier: Scopus)
51. Hiroyasu Nakano, Sachiko Sakon, Haruhiko Koseki, Toshitada Takemori, Kurisu Tada, Mitsuru Matsumoto, Eiko Munechika, Tsuyoshi Sasaki, Takuji Shirasawa, Hisaya Akiba, Tetsuji Kobata, Sybil M. Santee, Carl F. Ware, Paul D. Rennert, Masaru Taniguchi, Hideo Yagita and Ko Okumura :
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation,
Proceedings of the National Academy of Sciences of the United States of America, Vol.96, No.17, 9803-9808, 1999.
52. Mitsuru Matsumoto, Kikue Iwamasa, Paul D. Rennert, Takuji Yamada, Rika Suzuki, Akemi Matsushima, Masaru Okabe, Shigeru Fujita and Minesuke Yokoyama :
Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis,
The Journal of Immunology, Vol.163, No.3, 1584-1591, 1999.
(PubMed: 10415063,   Elsevier: Scopus)
53. Yang-Xin Fu, Guangming Huang, Mitsuru Matsumoto, Hector Molina and David D Chaplin :
Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node,
Proceedings of the National Academy of Sciences of the United States of America, Vol.94, No.11, 5739-5743, 1997.
54. Yang-Xin Fu, Hector Molina, Mitsuru Matsumoto, Guangming Huang, Jingjuan Min and David D Chaplin :
Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses,
The Journal of Experimental Medicine, Vol.185, No.12, 2111-2120, 1997.
55. Mitsuru Matsumoto, Yang-Xin Fu, Hector Molina, Guangming Huang, Jinho Kim, Dori A. Thomas, Moon H. Nahm and David D. Chaplin :
Distinct roles of lymphotoxin-alpha and the type I TNF receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells,
The Journal of Experimental Medicine, Vol.186, No.12, 1997-2004, 1997.
56. Mitsuru Matsumoto, Wataru Fukuda, Antonella Circolo, Joseph Goellner, Jena Strauss-Schoenberger, Xuefeng Wang, Shigeru Fujita, Tunde Hidvegi, David D Chaplin and Harvey R Colten :
Abrogation of the alternative complement pathway by targeted deletion of murine factor B,
Proceedings of the National Academy of Sciences of the United States of America, Vol.94, 8720-8725, 1997.
57. Mitsuru Matsumoto, Stanley F Lo, Cynthia JL Carruthers, Jingjuan Min, Sanjeev Mariathasan, Guangming Huang, David R Plas, Steven M Martin, Raif S Geha, Moon H Nahm and David D Chaplin :
Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice,
Nature, Vol.382, No.6590, 462-466, 1996.
(DOI: 10.1038/382462a0,   PubMed: 8684487)
58. Mitsuru Matsumoto, Sanjeev Mariathasan, Moon H Nahm, Ferenc Baranyay, Jacques J Peschon and David D Chaplin :
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers,
Science, Vol.271, No.5253, 1289-1291, 1996.
(DOI: 10.1126/science.271.5253.1289,   PubMed: 8638112)
59. Mitsuru Matsumoto, Yoshiki Tange, Takanori Okada, Yasuhiro Inoue, Takahiko Horiuchi, Yuzuru Kobayashi and Shigeru Fujita :
Deletion in the 190 kDa antigen gene repeat region of Rickettsia rickettsii,
Microbial Pathogenesis, Vol.20, No.1, 57-62, 1996.
(DOI: 10.1006/mpat.1996.0005,   PubMed: 8692010)
60. Sanjeev Mariathasan, Mitsuru Matsumoto, Ferenc Baranyay, Moon M Nahm, Osami Kanagawa and David D Chaplin :
Absence of lymph nodes in lymphotoxin-alpha (LTalpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration,
Journal of Inflammation, Vol.45, 72-78, 1995.

Review, Commentary:

1. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
AIRE - The Autoimmune Regulator,
eLS, Feb. 2019.
(DOI: 10.1002/9780470015902.a0027281)
2. Minoru Matsumoto, Koichi Tsuneyama and Mitsuru Matsumoto :
AIRE遺伝子と多腺性自己免疫症候群,
The Medical Frontline, Vol.73, No.5, 688-692, May 2018.
3. Mitsuru Matsumoto :
Switching on the Aire conditioner,
European Journal of Immunology, Vol.45, No.12, 3237-3240, Dec. 2015.
(DOI: 10.1002/eji.201546098,   PubMed: 26643138,   Elsevier: Scopus)
4. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri, Minoru Matsumoto and Hitoshi Nishijima :
Mechanisms underlying the establishment of T-cell tolerance in the thymus,
月​刊​臨​床​免​疫​・​ア​レ​ル​ギ​ー​科​, Vol.60, No.2, 70-77, Jul. 2013.
(CiNii: 40019752075)
5. Hitoshi Nishijima, Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化,
Seikagaku, Vol.85, No.7, 600, Jul. 2013.
6. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Yasuhiro Mouri :
Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?,
Frontiers in Immunology, Vol.4, 1-4, Jul. 2013.
(DOI: 10.3389/fimmu.2013.00210,   PubMed: 23885257,   Elsevier: Scopus)
7. Mitsuru Matsumoto :
Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla,
European Journal of Immunology, Vol.41, No.1, 12-17, Jan. 2011.
(DOI: 10.1002/eji.201041024,   PubMed: 21182071)
8. Mitsuru Matsumoto :
The role of autoimmune regulator (Aire) in the development of the immune system,
Microbes and Infection, Vol.11, No.12, 928-934, Jul. 2009.
(DOI: 10.1016/j.micinf.2009.07.003,   PubMed: 19615461)
9. Mitsuru Matsumoto :
Autoimmune regulator functions in autoimmunity control.,
Expert Review of Clinical Immunology, Vol.3, No.6, 891-900, Nov. 2007.
(DOI: 10.1586/1744666X.3.6.891,   PubMed: 20477138,   Elsevier: Scopus)
10. Mitsuru Matsumoto :
NF-κB activation pathway in thymic epithelial cells controls establishment of self-tolerance,
Inflammation and Regeneration, Vol.27, No.3, 165-170, 2007.
(DOI: 10.2492/inflammregen.27.165)
11. Mitsuru Matsumoto :
Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance,
Archivum Immunologiae et Therapiae Experimentalis, Vol.55, No.1, 27-34, 2007.
(DOI: 10.1007/s00005-007-0007-9,   PubMed: 17277892)
12. Mitsuru Matsumoto :
Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting,
The Journal of Medical Investigation : JMI, Vol.46, No.3,4, 141-150, Aug. 1999.
(Tokushima University Institutional Repository: 21957,   PubMed: 10687308)
13. Mitsuru Matsumoto, Yang-Xin Fu, Hector Molina and David D. Chaplin :
Lymphotoxin-alpha deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers,
Immunological Reviews, Vol.156, 137-144, 1997.

Proceeding of International Conference:

1. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa and Hitoshi Nishijima :
Aire-dependent establishment of self-tolerance studied by genetically modified mice,
EMBO Workshop ThymE, Israel, May 2019.
2. Minoru Matsumoto, Junko Morimoto, Mitsuru Matsumoto and Hitoshi Nishijima :
Tissue-specific autoimmunity modified by Aire in thymic and peripheral tolerance,
5th International Congress on Controversies in Rheumatology and Autoimmunity (CORA), Italy, Mar. 2019.
3. Mitsuru Matsumoto, Minoru Matsumoto, Junko Morimoto, Koichi Tsuneyama and Hitoshi Nishijima :
Tissue-specific autoimmunity manipulated by Aire in thymic and peripheral tolerance,
Immunology of Diabetes Society Congress 2018, London, Oct. 2018.
4. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto and Hitoshi Nishijima :
Aire controls in trans the production of medullary thymic epithelial cells expressing Ly6C/Ly6G,
5th European Congress of Immunology 2018, Amsterdam, Sep. 2018.
5. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto and Mitsuru Matsumoto :
Distinct tissue-specific immune response revealed by manipulation of thymic and peripheral tolerance by Aire,
1st International Symposium for "Neo-self", Awaji, Japan, Jul. 2018.
6. Mitsuru Matsumoto :
Immune tolerance mediated by Aire,
1st International Symposium for "Neo-self", Awaji, Japan, Jul. 2018.
7. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity,
11th International Congress on Autoimmunity, Lisbon, Portugal, May 2018.
8. Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto :
Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells,
Immunology 2018 - AAI Annual Meeting, Austin, Texas, May 2018.
9. Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama and Hitoshi Nishijima :
A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression,
ThymOz8, Heron Island, Australia, Mar. 2018.
10. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD,
ThymOz8, Heron Island, Australia, Mar. 2018.
11. Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima and Mitsuru Matsumoto :
Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells,
5th Annual Meeting of the International Cytokine and Interferon Society, Kanazawa, Japan, Oct. 2017.
12. Junko Morimoto, Yumiko Nishikawa, Hitoshi Nishijima and Mitsuru Matsumoto :
Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function,
12th International Congress on SLE, Melbourne, Australia, Mar. 2017.
13. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE,
7th International Workshop of Kyoto T Cell Conference, Kyoto, Japan, Mar. 2017.
14. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice,
Controversies in Rheumatology and Autoimmunity 2017, Bologna, Italy, Mar. 2017.
15. Hitoshi Nishijima and Mitsuru Matsumoto :
Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells,
Cell Symposia - 100 Years of Phagocytosis, Sicily, Italy, Sep. 2016.
16. Hitoshi Nishijima and Mitsuru Matsumoto :
Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity,
Immunology 2016 - AAI Annual Meeting, Seattle, USA, May 2016.
17. Hitoshi Nishijima and Mitsuru Matsumoto :
Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity in mice,
The Fifth Bizan Immunology Symposium at University of Tokushima, Mar. 2016.
18. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto :
Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program,
The 4th European Congress of Immunology, Vienna, Austria, Sep. 2015.
19. Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka :
Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program,
Venice Thymus Meeting 2015, Venice, Italy, Apr. 2015.
20. Hiroshi Kawano and Mitsuru Matsumoto :
Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of Aire-expressing cells,
Controversies in Rheumatology and Autoimmunity 2015, Sorrento, Italy, Mar. 2015.
21. Mitsuru Matsumoto and Hitoshi Nishijima :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a medullary stromal factor,
European Society for Immunodeficiencies 2014, Prague, Czech Republic, Oct. 2014.
22. Hitoshi Nishijima and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment,
9th International Symposium of the Institute Network, Jun. 2014.
23. Hitoshi Nishijima, Junko Morimoto, Hiroshi Kawano, Yasuhiro Mouri, Koichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment,
ThymOz 7, Heron Island, Australia, Apr. 2014.
24. Mitsuru Matsumoto, Junko Morimoto, Hiroshi Kawano, Yasuhiro Mouri and Hitoshi Nishijima :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary microenvironment,
9th International Congress on Autoimmunity, Nice, France, Mar. 2014.
25. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Yumiko Nishikawa, Kouichi Ikuta and Mitsuru Matsumoto :
Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor within medullary microenvironment,
第3回 眉山免疫シンポジウム, Feb. 2014.
26. Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance,
WIP-Workshop, Munich, Germany, Oct. 2013.
27. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program,
15th ICI2013, Milan, Italy, Aug. 2013.
28. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Hans Fehling Joerg and Yasuhiro Mouri :
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program,
The 6th International Workshop of Kyoto T Cell Conference, Kyoto, Japan, Jun. 2013.
29. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage,
Immunology 2013 - AAI Annual Meeting, Honolulu, Hawaii, May 2013.
30. Yumiko Nishikawa, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program,
Controversies in Rheumatology and Autoimmunity (CORA 2011), Budapest, Hungary, Apr. 2013.
31. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Essential roles of Aire in the maturation program of Aire-expressing cell lineage(s) revealed by temporal fate-mapping approach,
The 10th International Conference on New Trends in Immunosuppression and Immunotherapy, Barcelona, Spain, Mar. 2013.
32. Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance,
2013 SKKU International Symposium on Molecular Medicine: New Trends in Cancer and Autoimmunity Research, Suwon, Republic of Korea, Feb. 2013.
33. Mitsuru Matsumoto :
Control of chronic inflammation through elucidation of organ-specific autoimmune disease mechanisms,
JST-CREST International Symposium, Tokyo, Japan, Feb. 2013.
34. Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self tolerance,
Centennial of Hashimoto Disease, Fukuoka, Japan, Dec. 2012.
35. Yumiko Nishikawa and Mitsuru Matsumoto :
Temporal fate-mapping approach reveals a requirement of Aire for the full maturation program of thymic epithelial cells in the medulla,
International Symposium on Genetic and Epigenetic Control of Cell Fate, Kyoto, Japan, Nov. 2012.
36. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri, Fumiko Hirota and Hitoshi Nishijima :
Temporal fate-mapping reveals essential roles of Aire in the maturation program of mTECs,
ThymUS 2012, Florida, USA, Nov. 2012.
37. Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance,
IEIIS/HIS 2012, Tokyo, Japan, Oct. 2012.
38. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Functional analysis of Aire, a gene responsible for the hereditary type of autoimmune disease,
Days of Molecular Medicine 2012, Wien, Austria, Oct. 2012.
39. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Aire controls organization of thymic microenvironment for the establishment of self tolerance,
European Congress of Immunology 2012, Glasgow, Scotland, Sep. 2012.
40. Mitsuru Matsumoto :
Roles of Aire in thymic epithelial cells in the medulla for the establishment of self-tolerance,
The Federation of Clinical Immunology Societies (FOCiS) 2012, Vancouver, Canada, Jun. 2012.
41. Yasuhiro Mouri, Yumiko Nishikawa, Hitoshi Nishijima and Mitsuru Matsumoto :
AIRE-dependent organization of thymic microenvironment for the establishment of self tolerance,
5th Congress of the Federation of Immunological Societies of Asia Oceania, New Delhi, India, Mar. 2012.
42. Hitoshi Nishijima, Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells,
4th International Conference on Drug Discovery & Therapy, Dubai, UAE, Feb. 2012.
43. Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self tolerance,
The 4th symposium for the mext priority research on Immunological Self, Kyoto, Japan, Jan. 2012.
44. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Expression of Aire, a gene responsible for autoimmune disease, in ES cells,
Cell Symposia: Stem Cell Programming & Re-programming, Lisbon, Portugal, Dec. 2011.
45. Mitsuru Matsumoto, Yasuhiro Mouri, Yumiko Nishikawa and Hitoshi Nishijima :
Aire-dependent organization of thymic microenvironment for the establishment of self tolerance,
5th Asian Congress on Autoimmunity, Suntec City, Singapore, Nov. 2011.
46. Mitsuru Matsumoto, Yasuhiro Mouri, Yumiko Nishikawa and Hitoshi Nishijima :
Role of self-antigen expressed by Aire-expressing cells in the negative selection process,
5th International Conference on Autoimmunity: Mechanisms and Novel Treatments, Hersonissos, Crete, Greece, Sep. 2011.
47. Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri and Hitoshi Nishijima :
Aire-dependent organization of thymic microenvironment for the establishment of self tolerance,
EUThyme-Rolduc Meeting, Leeuwenhorst, The Netherlands, May 2011.
48. Yasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Yumiko Nishikawa, Koji Tamada, Lieping Chen, Josef M. Penninger, Jun-ichiro Inoue, Taishin Akiyama and Mitsuru Matsumoto :
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma,
13th International TNF Conference, TNF 2011, Awaji, Hyogo, May 2011.
49. Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima and Yasuhiro Mouri :
Role of Aire in the organization of thymic microenvironment,
Controversies in Rheumatology and Autoimmunity (CORA 2011), Florence, Italy, Mar. 2011.
50. Yumiko Nishikawa, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance,
Cutting Edge Immunology and its Clinical Application, Hulshort, The Netherlands, Mar. 2011.
51. Mitsuru Matsumoto :
Roles of thymic epithelial cells for the establishment of self-tolerance,
14th International Congress of Immunology, Kobe, Aug. 2010.
52. Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes,
14th International Congress of Immunology, Kobe, Aug. 2010.
53. Yumiko Nishikawa, Yasuhiro Mouri and Mitsuru Matsumoto :
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation,
14th International Congress of Immunology, Kobe, Aug. 2010.
54. Mitsuru Matsumoto and Yumiko Nishikawa :
Expression of Aire, a histone-binding module for H3K4me0, in ES cell,
Cold Spring Harbor Asia Conferences, Epigenetics, Chromatin & Transcription, Suzhou, China, May 2010.
55. Yasuhiro Mouri and Mitsuru Matsumoto :
Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes,
7th International Congress on Autoimmunity, Ljubljana, Slovenia, May 2010.
56. Mitsuru Matsumoto, Yumiko Nishikawa, Fumiko Hirota and Yasuhiro Mouri :
AIRE and autoimmune disease,
The 19th International Rheumatology Symposium, Kobe, Apr. 2010.
57. Mitsuru Matsumoto, Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Hiroshi Kawamoto and Yasuhiro Mouri :
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation,
ThymOz VI, Gladstone, Australia, Mar. 2010.
58. Takashi Sakai, HoangNam Tran, Sun Mi Kim, Li Liu, Xichuan Teng, Yuji Shishido, Mukai-Sakai Rika, Mitsuru Matsumoto, Kazunori Ishimura, Yoshio Hayashi, Ryuji Kaji and Kiyoshi Fukui :
Nucling, a novel stress-sensitive protein, regulates NF-kappa B activation,
The 4th International Congress on Stress Responses in Biology and Medicine, The 4th Annual Meeting of the Biomedical Society for Stress Response, Sapporo, Oct. 2009.
59. Mitsuru Matsumoto, Yumiko Nishikawa, Masashi Yano, Fumiko Hirota and Yasuhiro Mouri :
Aire-dependent organization of thymic microenvironment,
International KTCC 2009, Kyoto, Jun. 2009.
60. Yasuhiro Mouri, Masashi Yano and Mitsuru Matsumoto :
Roles of NIK in thymic epithelial cells for the establishment of central tolerance.,
12th International TNF Conference, Madrid, Apr. 2009.
61. Kazuko YORITA, Hideo Misaki, Mitsuru Matsumoto and Vincent Massey :
Function of Two Arginine Residues of L-Lactate Oxidase,
The 3rd International Conference on Oxygenases, Kyoto, Nov. 2000.

Proceeding of Domestic Conference:

1. Hitoshi Nishijima, Mizuki Sugita, Junko Morimoto, Minoru Matsumoto and Mitsuru Matsumoto :
Functional and transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression,
第42回日本分子生物学会年会, Dec. 2019.
2. Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Mitsuru Matsumoto :
Transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression,
第47回日本免疫学会学術集会, Dec. 2018.
3. Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto and Mitsuru Matsumoto :
Analysis of the role of thymic APCs and Aire in the production of thymic Tregs,
第47回日本免疫学会学術集会, Dec. 2018.
4. Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Mitsuru Matsumoto :
胸腺髄質上皮細胞における Aire 発現レベルと組織特異的自己抗原 遺伝子発現との関連性に関する検討,
28 Kyoto T cell Conference (KTCC), Jun. 2018.
5. Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto :
Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the impaired presentation of self-antigens in the pancreas,
第46回日本免疫学会学術集会, Dec. 2017.
6. Hiroshi Kawano, Mitsuru Matsumoto and Yasuhiko Nishioka :
ほぼすべての胸腺髄質上皮細胞が成熟過程でAireを発現する機能を備えている,
第28回日本リウマチ学会中国・四国支部学術集会, Nov. 2017.
7. Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity,
第45回日本免疫学会学術集会, Dec. 2016.
8. Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima and Mitsuru Matsumoto :
A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein,
第44回日本免疫学会学術集会, Nov. 2015.
9. Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano and Mitsuru Matsumoto :
Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE,
第44回日本免疫学会学術集会, Nov. 2015.
10. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Hiroshi Kawano, Koichi Ikuta and Mitsuru Matsumoto :
Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex,
第43回日本免疫学会学術集会, Dec. 2014.
11. Hiroshi Kawano, Junko Morimoto, Yasuhiro Mouri, Hitoshi Nishijima, Yasuhiko Nishioka and Mitsuru Matsumoto :
Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells,
第43回日本免疫学会学術集会, Dec. 2014.
12. Hitoshi Nishijima, Kouichi Ikuta and Mitsuru Matsumoto :
胸腺皮質上皮細胞への異所性発現による Aire の機能解析,
24 Kyoto T cell Conference (KTCC), May 2014.
13. Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri, Yumiko Nishikawa, Kouichi Ikuta and Mitsuru Matsumoto :
Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance,
第42回日本免疫学会総会, Dec. 2013.
14. Hitoshi Nishijima, Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells,
第35回日本分子生物学会年会, Dec. 2012.
15. Yasuhiro Mouri, Yumiko Nishikawa, Hitoshi Nishijima and Mitsuru Matsumoto :
Differential requirement of Aire in two transgenic models for the negative selection of autoreactive thymocytes against self-antigens,
第41回日本免疫学会学術集会, Dec. 2012.
16. Tomoyuki Yuasa, Toshiyuki Obata, Ichiro Yokota, Eiji Okamoto, Yoshiko Kanezaki, Hiroshi Maegawa, Fumiko Hirota, Kazuhiro Kishi, Seiichi Hashida, Hisao Nagaya, Ogura Yuko, Masuda Kazuhiko, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.,
International Symposium on Diabetes - Kickoff of Hannover-Tokushima Research Communiation, Mar. 2009.
17. Takashi Sakai, Li Liu, Rika Sakai, Ryuji Kaji, Tasuku Mitani, Mitsuru Matsumoto, Kazunori Toida, Yuji Shishido and Kiyoshi Fukui :
Nucling is important for the upregulation of Apaf-1/procaspase-9cytochrome c apoptosome following cellular stress in vivo,
The 77th Annual Meeting of the Japanese Biochemical Society, Oct. 2004.

Et cetera, Workshop:

1. Hitoshi Nishijima and Mitsuru Matsumoto :
ヒト AIRE トランスジェニックマウスに誘導される自己免疫性筋炎病態の解析,
第16回四国免疫フォーラム, Jun. 2017.
2. Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto and Mitsuru Matsumoto :
ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析,
第36回日本胸腺研究会, Feb. 2017.
3. Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano and Mitsuru Matsumoto :
NOD系統特異的に多発性筋炎様症状をもたらすゲノム領域の解析,
第14回四国免疫フォーラム, Jun. 2015.
4. Hitoshi Nishijima, Yasuhiro Mouri, Yumiko Nishikawa and Mitsuru Matsumoto :
AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化,
第54回日本生化学会 中国・四国支部例会, May 2013.
5. Tomoyuki Yuasa, Toshiyuki Obata, Ichiro Yokota, 岡本 英治, Hisao Nagaya, Seiichi Hashida, 前川 聡, Atsunori kasiwagi, Mitsuru Matsumoto, Toshio Matsumoto, Kazuhiro Kishi and Yousuke Ebina :
可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる,
第7回 1型糖尿病研究会, Nov. 2009.
6. Tomoyuki Yuasa, Toshiyuki Obata, Ichiro Yokota, Eiji Okamoto, Yoshiko Kanezaki, Hiroshi Maegawa, Fumiko Hirota, Kazuhiro Kishi, Seiichi Hashida, Hisao Nagaya, Ogura Yuko, Masuda Kazuhiko, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.,
The 1st Insulin Resistance in Metabolic Disease Forum, Aug. 2008.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • GPIアンカー型タンパク質Ly6C分子による免疫応答調節機構の解明 (Project/Area Number: 19K07626 )
  • AIREを基軸とする自己免疫疾患の病態解明、ならびに新規治療法の開発 (Project/Area Number: 19H03699 )
  • 自己免疫病態におけるアンビバレンス(両価性)の解読 (Project/Area Number: 18K19564 )
  • 胸腺におけるネオ・セルフ生成機構 (Project/Area Number: 16H06496 )
  • ネオ・セルフの生成・機能・構造の総括的理解 (Project/Area Number: 16H06495 )
  • ネオ・セルフの生成・機能・構造に対する国際活動支援 (Project/Area Number: 16K21731 )
  • Elucidation of the pathogenesis of autoimmune disease through the functional study of AIRE (Project/Area Number: 16H05342 )
  • Studies on the mechanisms for autoimmune phenotype in disease model mouse (Project/Area Number: 26461464 )
  • Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function (Project/Area Number: 26460577 )
  • Role of Aire in the early development of zebrafish (Project/Area Number: 25670231 )
  • Studies aiming the establishing self-tolerance for the cure of autoimmune disease (Project/Area Number: 25293223 )
  • 胸腺髄質上皮細胞分化機構の解明 (Project/Area Number: 23118520 )
  • Studies on the mechanisms for the prevention of diabetes in NOD mice by AIRE expression (Project/Area Number: 23591437 )
  • Roles of AIRE in the development of early embryos and in the establishment of immunological self-tolerance (Project/Area Number: 22659097 )
  • Transgenic mouse approaches to the pathogenesis of hereditary type of human autoimmune disease (Project/Area Number: 21390298 )
  • Studies on the functian of AIRE, a gene responsible for the hereditary type of autoimmune disease (Project/Area Number: 19390274 )
  • 免疫システムにおけるオートファジーの役割 (Project/Area Number: 19044027 )
  • Thymic microenvironments for shaping T cell repertoire (Project/Area Number: 19059010 )
  • The analysis of the mechanism for tissue specificity autoimmune (Project/Area Number: 18590473 )
  • 自己免疫疾患の病態に関わる胸腺ニッチ構築シグナルの解明 (Project/Area Number: 18060030 )
  • Analysis of the role of autoimmune regulator (AIRE) gene in autoimmune diseases development (Project/Area Number: 17590435 )
  • Functional analysis ofAIRE, a gene responsible for the hereditary type of autoimmune disease (Project/Area Number: 17390291 )
  • 自己抗原のプロセッシング障害による自己寛容破綻病態の解明 (Project/Area Number: 17047028 )
  • プロテオミクスの手法を用いた自己免疫疾患の発症に関わる胸腺内蛋白同定の試み (Project/Area Number: 15659116 )
  • Functional analysis of AIRE, a gene responsible for the hereditary type of autoimmune disease. (Project/Area Number: 15390315 )
  • がん免疫と自己免疫との新たな接点の探索 (Project/Area Number: 15023242 )
  • 自己免疫および真菌感染の成立機構の両者に働く遺伝子の機能解析 (Project/Area Number: 15019070 )
  • 可視化タンパク質を用いた新たなタンパク質処理機構の解明 (Project/Area Number: 14037248 )
  • リンパ組織構築化とT細胞活性化を同時に担う分子による免疫システム賦活化機構の解析 (Project/Area Number: 14030059 )
  • 自己免疫および真菌感染の成立機構の両者に働く遺伝子の機能解析 (Project/Area Number: 14021079 )
  • 主要組織適合抗原複合体領域に存在する疾患感受性遺伝子の検索 (Project/Area Number: 14013044 )
  • 生体内での測定を目指した簡便な一酸化窒素(NO)測定技術の開発 (Project/Area Number: 13877401 )
  • Functional analysis of the non-HLA genes within major histocompatibility complex (MHC) region with the use of gene-targeted mice (Project/Area Number: 13670320 )
  • 2本鎖RNAに対する宿主応答機構の解析 (Project/Area Number: 13226082 )
  • がん治療に向けた免疫調節機構に関する研究:TNFファミリー分子を中心とした解析 (Project/Area Number: 13218091 )
  • 体細胞クローン技術を応用した新たなノックアウトマウス作製法の開発 (Project/Area Number: 12878159 )
  • 濾胞樹状細胞の構築に関わるリンホトキシン作用の解析 (Project/Area Number: 12051231 )
  • Functional analysis of the non-HLA genes within major histocompatibility complex (MHC) region with the use of gene-targeted mice (Project/Area Number: 11557013 )
  • 接触性過敏反応の病態におけるリンホトキシンの役割 (Project/Area Number: 10167215 )
  • Role of lymphotoxin in lymphoid organogenesis and contact hypersensitivity. (Project/Area Number: 09670478 )
  • Search by Researcher Number (60221595)