徳島大学 / 教育研究者総覧 --- 山内あい子

専門分野

○	医薬品適正使用
○	医薬品情報学 (Pharmaceutical Information Science)
○	薬物の代謝および毒性

研究テーマ

○	薬物療法における医薬品の安全性と適正使用に関する研究 (薬物治療, 医薬品の適正使用)
○	医薬品安全性情報コミュニティの構築にむけて (医薬品情報学 (pharmaceutical information science))
○	ハロゲン化炭化水素による腎細胞毒性発現機構，ヒト肺非小細胞癌における抗癌剤多剤耐性機構，ラット脳灌流モデルによる薬物の脳脊髄液移行性評価 (薬物代謝·毒性, 化学療法)

著書・論文

著書:

1.	Aiko Yamauchi and Hiroshi Chuman : Data mining approach on clinical/pharmaceutical information accumulatedin the drug safety information community, in "Complex Medical Engineering", Springer-Verlag, Tokyo, Jan. 2007.
2.	AHMAD AMMAR GHAIBEH, Mikio Sasaki, Doolin Eiko Nakata, Kumiko Sakamoto, Hiroshi Chuman and Aiko Yamauchi : Using computational intelligence methods in a web-based drug safety information community, in "Complex Medical Engineering", Springer-Verlag, Tokyo, Jan. 2007.
3.	岡野善郎, 神谷晃, 松山賢治, 山内あい子 : 疾病·病態マニュアル改訂第二版, 株式会社南山堂, 東京, 2005年1月.
4.	岡野善郎, 神谷晃, 松山賢治, 山内あい子 : 疾病·病態マニュアル, 株式会社南山堂, 東京, 1999年10月.
5.	山内あい子 : 薬物相互作用の考え方, 兵庫県薬剤師会, 神戸, 1996年3月.
6.	谷村顕雄, 藤井正美, 義平邦利, 伊藤誉志男, 山内あい子 : 食品中の食品添加物分析法解説書, 株式会社講談社, 東京, 1992年5月.
7.	紀氏武雄, 山内あい子, 福森義信 : 第6回神戸学院大学薬学部海外研修セミナーレポート, 神戸学院大学薬学部, 神戸, 1989年3月.
8.	山内あい子 : 中枢神経系におけるキニンの役割に関する研究, 東京大学, 東京, 1985年12月.

学術論文(審査論文):

1.	Tomoko Otani, Yasuko Kase, Kazufumi Kunitomo, Kazumi Shimooka, Mitsugu Naoe, Hiroko Yamamoto, Kazuyoshi Kawazoe, Youichi Sato and Aiko Yamauchi : Novel formula using triceps skinfold thickness to revise the Cockcroft-Gault equation for estimating renal function in Japanese bedridden elderly patients, The Journal of Medical Investigation : JMI, Vol.65, No.3-4, 195-202, 2018. (要約) In recumbent elderly patients, creatinine clearance (eCCr) estimated by the Cockcroft-Gault (CG) equation may not necessarily reflect renal function. We aimed to develop a novel formula to revise the CG equation using anthropometric measurements in bedridden elderly patients and evaluate its clinical utility. The subjects included 77 bedridden Japanese patients aged ≦ 65, hospitalized at Naruto Yamakami Hospital. The actual CCr (mCCr) value was measured using the 24-hour urine collection method. Anthropometric data, such as skeletal muscle mass, body fat mass (BFM), and triceps skinfold thickness (TSF), were collected. We established a novel formula to estimate CCr or CCr by correcting the eCCr value with BFM or TSF. The stage of classification of renal dysfunctions in patients with eGFR or eGFR was equivalent to the GFR based on the mCCr. Notably, the novel equation for eCCr based on TSF (eCCr), dubbed the "Naruto" formula, can be useful to evaluate renal function in bedridden elderly patients without expensive equipment or additional costs. In this study, mCCr was considered to be the true renal function of the patient, but whether and to what extent mCCr correlates with inulin clearance is unknown. J. Med. Invest. 65:195-202, August, 2018. (徳島大学機関リポジトリ) ● Metadata: 112237 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.65.195 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282860 ● Summary page in Scopus @ Elsevier: 2-s2.0-85054455235 (徳島大学機関リポジトリ: 112237, DOI: 10.2152/jmi.65.195, PubMed: 30282860, Elsevier: Scopus)
2.	Tomoko Otani, Yasuko Kase, Kazufumi Kunitomo, Kazumi Shimooka, Mitsugu Naoe, Hiroko Yamamoto, Kazuyoshi Kawazoe, Youichi Sato and Aiko Yamauchi : What is the correct adjustment protocol for serum creatinine value to reflect renal function in bedridden elderly patients?, The Japanese Journal of Nephrology and Pharmacotherapy, Vol.7, No.1, 3-12, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.24595/jjnp.7.1_3 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.24595/jjnp.7.1_3 (DOI: 10.24595/jjnp.7.1_3)
3.	Youichi Sato, Atsushi Tajima, Takehiro Sato, Shiari Nozawa, Miki Yoshiike, Issei Imoto, Aiko Yamauchi and Teruaki Iwamoto : Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men., Journal of Medical Genetics, Vol.55, No.6, 415-421, 2018. (要約) The decrease in sperm motility has a potent influence on fertilisation. Sperm motility, represented as the percentage of motile sperm in ejaculated sperms, is influenced by lifestyle habits or environmental factors and by inherited factors. However, genetic factors contributing to individual differences in sperm motility remain unclear. To identify genetic factors that influence human sperm motility, we performed a genome-wide association study (GWAS) of sperm motility. A two-stage GWAS was conducted using 811 Japanese men in a discovery stage, followed by a replication study using an additional 779 Japanese men. In the two-staged GWAS, a single nucleotide polymorphism rs3791686 in the intron of gene for erb-b2 receptor tyrosine kinase 4 () on chromosome 2q34 was identified as a novel locus for sperm motility, as evident from the discovery and replication results using meta-analysis (β=-4.01, combined P=5.40×10). Together with the previous evidence that Sertoli cell-specific -knockout mice display an impaired ability to produce motile sperm, this finding provides the first genetic evidence for further investigation of the genome-wide significant association at the locus in larger studies across diverse human populations. (徳島大学機関リポジトリ) ● Metadata: 113933 (出版サイトへのリンク) ● Publication site (DOI): 10.1136/jmedgenet-2017-104991 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29453196 ● Search Scopus @ Elsevier (PMID): 29453196 ● Search Scopus @ Elsevier (DOI): 10.1136/jmedgenet-2017-104991 (徳島大学機関リポジトリ: 113933, DOI: 10.1136/jmedgenet-2017-104991, PubMed: 29453196)
4.	Youichi Sato, Chise Hasegawa, Atsushi Tajima, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Aiko Yamauchi and Teruaki Iwamoto : Association of TUSC1 and DPF3 gene polymorphisms with male infertility, Journal of Assisted Reproduction and Genetics, Vol.35, No.2, 257-263, 2018. (要約) Recently, genome-wide association studies of a Hutterite population in the USA revealed that five single nucleotide polymorphisms (SNPs) with a significant association with sperm quality and/or function in ethnically diverse men from Chicago were significantly correlated with family size. Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population. In this study, we investigated whether the rs10966811 (located in an intergenic region between the TUSC1 and IZUMO3 genes) and rs10129954 (located in the DPF3 gene) SNPs, previously related to family size, are associated with male infertility. In addition, we performed association analysis between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility. We genotyped 145 patients with infertility (including 83 patients with azoospermia and 62 with oligozoospermia) and 713 fertile controls by PCR-RFLP technique for polymorphism. Because rs10966811 has no restriction sites, the SNP rs12376894 with strong linkage disequilibrium was selected as an alternative to rs10966811. There was a statistically significant association between rs12376894 proxy SNP of rs10966811 and oligozoospermia. Also, a statistically significant association between rs10129954 and azoospermia, and oligozoospermia was observed. When we assessed the relationship between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility traits, we found that rs12348 in TUSC1 was significantly associated with azoospermia and oligozoospermia, but rs2772579 in IZUMO3 was not associated with male infertility. We found that the polymorphisms in TUSC1 and DPF3 displayed strong associations with male infertility. (徳島大学機関リポジトリ) ● Metadata: 113935 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10815-017-1052-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28975488 ● Search Scopus @ Elsevier (PMID): 28975488 ● Search Scopus @ Elsevier (DOI): 10.1007/s10815-017-1052-x (徳島大学機関リポジトリ: 113935, DOI: 10.1007/s10815-017-1052-x, PubMed: 28975488)
5.	Youichi Sato, Atsushi Tajima, Motoki Katsurayama, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Issei Imoto, Aiko Yamauchi and Teruaki Iwamoto : An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies, Human Reproduction Open, Vol.2017, No.1, 1-8, 2017. (徳島大学機関リポジトリ) ● Metadata: 111006 (出版サイトへのリンク) ● Publication site (DOI): 10.1093/hropen/hox002 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1093/hropen/hox002 (徳島大学機関リポジトリ: 111006, DOI: 10.1093/hropen/hox002)
6.	Kiyotake Yamamoto, Hiroyuki Mizuguchi, Natsumi Tokashiki, Makoto Kobayashi, Motoyuki Tamaki, Youichi Sato, Hiroyuki Fukui and Aiko Yamauchi : Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets, The Journal of Medical Investigation : JMI, Vol.64, No.1,2, 122-128, 2017. (要約) Accumulating evidence supports the "glucagonocentric hypothesis", in which antecedent -cell failure and inhibition of glucagon secretion are responsible for diabetes progression. Protein kinase C (PKC) is involved in glucagon secretion from -cells, although which PKC isozyme is involved and the mechanism underlying this PKC-regulated glucagon secretion remains unknown. Here, the involvement of PKC in the onset and progression of diabetes was elucidated. Immunofluorescence studies revealed that PKC was expressed and activated in -cells of STZ-induced diabetic model mice. Phorbol 12-myristate 13-acetate (PMA) stimulation significantly augmented glucagon secretion from isolated islets. Pre-treatment with quercetin and rottlerin, PKC signaling inhibitors, significantly suppressed the PMA-induced elevation of glucagon secretion. While Go6976, a Ca(2+)-dependent PKC selective inhibitor did not suppress glucagon secretion. Quercetin suppressed PMA-induced phosphorylation of Tyr(311) of PKC in isolated islets. However, quercetin itself had no effect on either glucagon secretion or glucagon mRNA expression. Our data suggest that PKC signaling inhibitors suppressed glucagon secretion. Elucidation of detailed signaling pathways causing PKC activation in the onset and progression of diabetes followed by the augmentation of glucagon secretion could lead to the identification of novel therapeutic target molecules and the development of novel therapeutic drugs for diabetes. J. Med. Invest. 64: 122-128, February, 2017. (徳島大学機関リポジトリ) ● Metadata: 111099 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.64.122 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373608 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016425921 (徳島大学機関リポジトリ: 111099, DOI: 10.2152/jmi.64.122, PubMed: 28373608, Elsevier: Scopus)
7.	Youichi Sato, Atsushi Tajima, Motoki Katsurayama, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Issei Imoto, Aiko Yamauchi and Teruaki Iwamoto : A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men, Journal of Human Genetics, Vol.61, No.11, 911-915, 2016. (要約) In men, follicle-stimulating hormone (FSH) acts on the seminiferous tubules and enhances spermatogenesis. Recently, a candidate locus (rs2414095) for FSH levels was identified by a genome-wide association study (GWAS) in Chinese men. The rs2414095 single-nucleotide polymorphism (SNP) is found on the third intron of the cytochrome P450, family 19, subfamily A, peptide 1 (CYP19A1) gene encoding an aromatase. In the present study, we performed a replication study in 1687 Japanese men (901 from cohort 1 and 786 from cohort 2) to assess whether this SNP is associated with circulating FSH levels. Furthermore, we investigated whether the rs2414095 SNP is correlated with semen quality traits in 2015 Japanese men (1224 from cohort 1 and 791 from cohort 2). The rs2414095 SNP was significantly associated with circulating FSH levels (STD=0.15, P=9.7 × 10(-5)), sperm concentration (STD=0.073, P=0.032) and total sperm number (TSN) (STD=0.074, P=0.027) in a combined analysis of the two Japanese male cohorts. We successfully replicated, in Japanese men, the results of the previous GWAS for the rs2414095 SNP in Chinese men, and found that the rs2414095 SNP was related with sperm production. (キーワード) Adult / Alleles / Cohort Studies / Follicle Stimulating Hormone / Genetic Association Studies / Genotype / Gonadal Steroid Hormones / Humans / Japan / Male / Polymorphism, Single Nucleotide / Quantitative Trait Loci / Quantitative Trait, Heritable / Semen Analysis / Sperm Count / Sperm Motility (徳島大学機関リポジトリ) ● Metadata: 109999 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/jhg.2016.82 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27357427 ● Search Scopus @ Elsevier (PMID): 27357427 ● Search Scopus @ Elsevier (DOI): 10.1038/jhg.2016.82 (徳島大学機関リポジトリ: 109999, DOI: 10.1038/jhg.2016.82, PubMed: 27357427)
8.	Masaya Denda, Takuya Morisaki, Taiki Kohiki, Jun Yamamoto, Kohei Sato, Ikuko Sagawa, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide, Organic & Biomolecular Chemistry, Vol.14, 6244-6251, 2016. (徳島大学機関リポジトリ) ● Metadata: 111885 (出版サイトへのリンク) ● Publication site (DOI): 10.1039/C6OB01014H (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1039/C6OB01014H (徳島大学機関リポジトリ: 111885, DOI: 10.1039/C6OB01014H)
9.	Youichi Sato, Atsushi Tajima, Kouki Tsunematsu, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Issei Imoto, Aiko Yamauchi and Teruaki Iwamoto : Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study, Human Reproduction, Vol.30, No.6, 1505-1509, 2015. (要約) Are the four candidate loci (rs7867029, rs12870438, rs7174015 and rs724078) for human male fertility traits, identified in a genome-wide association study (GWAS) of a Hutterite population in the USA, associated with semen quality traits in a Japanese population? The four single nucleotide polymorphisms (SNPs) rs7867029, rs12870438, rs7174015 and rs724078 have no association with semen parameters in a meta-analysis of two Japanese male cohorts. Four (rs7867029, rs12870438, rs7174015 and rs724078) of the SNPs associated with family size or birth rate in the GWAS of a Hutterite population in the USA were associated with semen parameters in ethnically diverse men from Chicago, USA. This is a replication study in a total of 2015 Japanese subjects, including 791 fertile men and 1224 young men from the general population. We performed a replication study in two cohorts to assess whether the SNPs rs7867029, rs12870438, rs7174015 and rs724078 are associated with sperm concentration, semen volume, total sperm numbers, total motile sperm numbers or sperm motility. The rs12870438 SNP was detected by restriction fragment length polymorphism PCR while rs7174015, rs724078 and rs7867029 SNPs were genotyped using TaqMan probes. This study indicated that none of the four SNPs rs7867029, rs12870438, rs7174015 and rs724078 displayed a significant association with semen parameters in the meta-analysis of two Japanese male cohorts. Only four SNPs identified in the Hutterite GWAS were examined for associations with semen quality traits in a Japanese population. In addition, the linkage disequilibrium structures around the testing markers were different between ethnic groups. Locus mapping studies using a set of tagging SNPs across the loci will be necessary in populations with larger sample sizes in order to understand the contribution of specific genes to semen quality. This study was supported in part by the Ministry of Health and Welfare of Japan (1013201) (to T.I.), Grant-in-Aids for Scientific Research (C) (23510242) (to A.Ta.) from the Japan Society for the Promotion of Science, the European Union (BMH4-CT96-0314) (to T.I.), and the Takeda Science Foundation (to A.Ta.). None of the authors has any competing interests to declare. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/humrep/dev081 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25908655 ● Summary page in Scopus @ Elsevier: 2-s2.0-84939638739 (DOI: 10.1093/humrep/dev081, PubMed: 25908655, Elsevier: Scopus)
10.	Youichi Sato, Atsushi Tajima, Kouki Tsunematsu, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Issei Imoto, Aiko Yamauchi and Teruaki Iwamoto : An association study of four candidate loci for human male fertility traits with male infertility, Human Reproduction, Vol.30, No.6, 1510-1514, 2015. (要約) Are the four candidate loci (rs7867029, rs7174015, rs12870438 and rs724078) for human male fertility traits, identified in a genome-wide association study (GWAS) of a Hutterite population in the USA, associated with male infertility in a Japanese population? rs7867029, rs7174015 and rs12870438 are significantly associated with the risk of male infertility in a Japanese population. Recently, a GWAS of a Hutterite population in the USA revealed that 41 single-nucleotide polymorphisms (SNPs) were significantly correlated with family size or birth rate. Of these, four SNPs (rs7867029, rs7174015, rs12870438 and rs724078) were found to be associated with semen parameters in ethnically diverse men from Chicago. This is a case-control association study in a total of 917 Japanese subjects, including 791 fertile men, 76 patients with azoospermia and 50 patients with oligozoospermia. Azoospermia was diagnosed on the basis of semen analysis (the absence of sperm in ejaculate), serum hormone levels and physical examinations. Oligozoospermia was defined as a sperm concentration of <20 × 10(6)/ml. We excluded patients with any known cause of infertility (i.e. obstructive azoospermia, varicocele, cryptorchidism, hypogonadotropic hypogonadism, karyotype abnormalities or complete deletion of AZF a, b or c). The SNPs rs7867029, rs7174015, rs12870438 and rs724078 were genotyped using DNA from peripheral blood samples and either restriction fragment length polymorphism PCR or TaqMan probes. Genetic associations between the four SNPs and male infertility were assessed using a logistic regression analysis under three different comparative models (additive, recessive or dominant). The genotypes of all four SNPs were in Hardy-Weinberg equilibrium in the fertile controls. The SNPs rs7867029 and rs7174015 are associated with oligozoospermia [rs7867029: odds ratio (OR) = 1.70, 95% confidence interval (CI) = 1.07-2.68, P = 0.024 (log-additive); rs7174015: OR = 6.52, 95% CI = 1.57-27.10, P = 0.0099 (dominant)] and rs12870438 is associated with azoospermia (OR = 10.90, 95% CI = 2.67-44.60, P = 0.00087 (recessive)] and oligozoospermia [OR = 8.54, 95% CI = 1.52-47.90, P = 0.015 (recessive)]. The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing. There were no associations between rs724078 and azoospermia or oligozoospermia. Even though the sample size of case subjects was not very large, we found that three SNPs were associated with the risk of male infertility in a Japanese population. The three infertility-associated SNPs may be contributing to a quantitative reduction in spermatogenesis. This study was supported in part by the Ministry of Health and Welfare of Japan (1013201) (to T.I.), Grant-in-Aids for Scientific Research (C) (23510242) (to A.Ta.) from the Japan Society for the Promotion of Science, the European Union (BMH4-CT96-0314) (to T. I.) and the Takeda Science Foundation (to A.Ta.). None of the authors has any competing interests to declare. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/humrep/dev088 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25908656 ● Summary page in Scopus @ Elsevier: 2-s2.0-84939605579 (DOI: 10.1093/humrep/dev088, PubMed: 25908656, Elsevier: Scopus)
11.	Youichi Sato, Toshikatsu Shinka, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Aiko Yamauchi, Teruaki Iwamoto and Yutaka Nakahori : Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men, Andrology, Vol.3, No.3, 520-525, 2015. (要約) The association between the Y chromosome haplogroup D2 and risk of azoospermia and low sperm motility has been previously studied, and it was indicated that haplogroups DE (YAP lineage) are associated with prostate cancer risk in Japanese males. Our assumption had been that Y chromosome haplogroups may be associated with sex hormone levels, because sex hormones have been deemed responsible for spermatogenesis and carcinogenesis. In this study, we assessed the association between Y chromosome haplogroups and sex hormone levels, including those of testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin-B, and calculated free testosterone (cFT), in 901 young men from the general Japanese population (cohort 1) and 786 Japanese men of proven fertility (cohort 2). We found that the haplogroup D2a1 was significantly associated with high LH levels in a combined analysis involving two cohorts (β = 0.068, SE = 0.025, p = 0.0075), following correction for multiple testing. To date, this result is the first evidence that implicates Y chromosome haplogroups in an association with sex hormone levels. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/andr.12026 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25858496 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929842765 (DOI: 10.1111/andr.12026, PubMed: 25858496, Elsevier: Scopus)
12.	Youichi Sato, Toshikatsu Shinka, ASHRAF ABDEL AZIM EWIS, Aiko Yamauchi, Teruaki Iwamoto and Yutaka Nakahori : Overview of genetic variation in the Y chromosome of modern Japanese males, Anthropological Science, Vol.122, No.3, 131-136, 2014. (出版サイトへのリンク) ● Publication site (DOI): 10.1537/ase.140709 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-84919705410 (DOI: 10.1537/ase.140709, Elsevier: Scopus)
13.	Youichi Sato, Takanobu Kamada and Aiko Yamauchi : The role of dipeptidyl peptidase 4 (DPP4) in the preservation of renal function: DPP4 involvement in hemoglobin expression, The Journal of Endocrinology, Vol.223, No.2, 133-142, 2014. (要約) In a previous study, we demonstrated that dipeptidyl peptidase 4 (DPP4)-deficient rats were susceptible to reduced glomerular filtration rate as a result of streptozotocin (STZ)-induced diabetes. Therefore, we proposed that DPP4 might be responsible for the preservation of renal function. In this study, to verify the role of DPP4 in the preservation of renal function, we performed a microarray analysis of the kidneys of WT and DPP4-deficient rats after STZ treatment, and gene expression analysis using rat kidneys, human embryonic kidney 293 (HEK293) cells, and human renal cancer cells (CakI-1). The microarray analysis indicated that the expression levels of the transporter activity, heme-binding, and pheromone binding-related genes changed significantly. The results of gene expression analysis indicated that there were no significant differences in the expression levels of hemoglobin mRNA between the DPP4-deficient and WT rats; however, the expression levels of hemoglobin mRNA in the kidneys of DPP4-deficient rats tended to decrease when compared with those of both the non-STZ-treated and STZ-treated WT rats. The expression levels of hemoglobin in HEK293 and Caki-1 cells were significantly decreased when DPP4 was knocked down by siRNA, were significantly increased by the addition of soluble human DPP4, and were also significantly increased by the addition of the DPP4 inhibitor, sitagliptin. The expression level of DPP4 was also significantly increased by the addition of sitagliptin in both cell types. Our findings indicate that DPP4 regulates the expression of the hemoglobin genes, and might play a role in the preservation of renal function; however, the underlying mechanism of this preservation remains to be elucidated. (出版サイトへのリンク) ● Publication site (DOI): 10.1530/JOE-14-0016 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25122001 ● Search Scopus @ Elsevier (PMID): 25122001 ● Search Scopus @ Elsevier (DOI): 10.1530/JOE-14-0016 (DOI: 10.1530/JOE-14-0016, PubMed: 25122001)
14.	Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker, Tetrahedron, Vol.70, No.34, 5122-5127, 2014. (徳島大学機関リポジトリ) ● Metadata: 111908 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.tet.2014.05.110 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-84903391352 (徳島大学機関リポジトリ: 111908, DOI: 10.1016/j.tet.2014.05.110, Elsevier: Scopus)
15.	Youichi Sato, Iwamoto Teruaki, Toshikatsu Shinka, Nozawa Shiari, Yoshiike Miki, Koh Eitetsue, Kanaya Jiro, Namiki Mikio, Matsumiya Kiyomi, Tsujimura Akira, Komatsu Kiyoshi, Itoh Naoki, Eguchi Jiro, Aiko Yamauchi and Yutaka Nakahori : Y chromosome gr/gr subdeletion is associated with lower semen quality in young men from the general Japanese population but not in fertile Japanese men, Biology of Reproduction, Vol.90, No.6, 116, 2014. (要約) Several case-control studies have investigated whether Y chromosome haplogroups or deletions are associated with spermatogenic failure. However, the relationships between Y chromosome haplogroups or deletions and semen quality in general population have not been elucidated. In this study, we assessed relationships between Y chromosome haplogroups or deletions and semen parameters in 791 fertile Japanese men and 1221 young men from the general Japanese population. We found that the haplogroup D2 (M55 lineage) was significantly associated with lower semen parameters, especially total motile sperm count (P = 0.00051, beta = -0.097), in men from the general population but not in fertile men. In addition, we found that the gr/gr subdeletion was associated with semen quality and in particular, strongly associated with decreased sperm motility (P = 0.00041, beta = -3.14) and total motile sperm count (P = 0.00031, beta = -0.099) in men from the general population but not in fertile men. The combined analysis of fertile Japanese men and men from the general Japanese population showed that the haplogroup D2 (M55 lineage) and the gr/gr subdeletion were strongly associated with reduced sperm motility (P = 0.00056, beta = -2.71, and P = 7.7 × 10(-5), beta = -3.05, respectively) and that haplogroup O2b1 was strongly associated with elevated sperm motility (P = 0.00089, beta = 2.94). These observations add further support for the view that the gr/gr subdeletion diminishes sperm motility that consequently may result in male infertility. (キーワード) Adolescent / Adult / Asian Continental Ancestry Group / Chromosome Deletion / Chromosomes, Human, Y / Female / Fertility / Haplotypes / Humans / Infertility, Male / Japan / Male / Middle Aged / Pregnancy / Prevalence / Semen Analysis / Spermatozoa / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1095/biolreprod.114.118810 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24759788 ● Summary page in Scopus @ Elsevier: 2-s2.0-84903756731 (DOI: 10.1095/biolreprod.114.118810, PubMed: 24759788, Elsevier: Scopus)
16.	Mai Nagao, Youichi Sato and Aiko Yamauchi : Meta-Analysis of Interleukin Polymorphisms and NSAID Usage Indicates Correlations to the Risk of Developing Cancer, International Journal of Genomic Medicine, Vol.2, No.1, 1000113, 2014. (出版サイトへのリンク) ● Publication site (DOI): 10.4172/2332-0672.1000113 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.4172/2332-0672.1000113 (DOI: 10.4172/2332-0672.1000113)
17.	Nagao Mai, Youichi Sato and Aiko Yamauchi : A meta-analysis of the association of PPARγ rs1801282 polymorphism and NSAID usage with the risk of developing cancer, Biological & Pharmaceutical Bulletin, Vol.37, No.6, 1062-1067, 2014. (要約) Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is correlated with a reduced risk of cancer through the reduction of inflammation, which is an important risk factor. Several studies have investigated polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and NSAID use in association with cancer risk. However, these studies yielded mixed results. Therefore, we performed a meta-analysis to evaluate the association of PPARγ polymorphisms and NSAID usage with cancer risk. We conducted a comprehensive search of PubMed through May 2013. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated using the fixed-effect or random-effect model. A comprehensive search of the database revealed 6 studies that fulfilled the inclusion criteria. NSAID use was significantly associated with decreased cancer risk regardless of PPARγ rs1801282 genotypes. In a stratified analysis by cancer type, NSAID users who were minor allele carriers had significantly decreased colon cancer risk compared to non-NSAID users (OR=0.73, 95% CI=0.57-0.93), whereas NSAID users homozygous for the major allele had significantly decreased risk for cancers other than colon cancer compared to non-NSAID users (OR=0.79, 95% CI=0.69-0.91). Our results suggest that the association of PPARγ rs1801282 polymorphism and NSAID use with the risk of cancer may differ according to cancer type. (キーワード) Alleles / Anti-Inflammatory Agents, Non-Steroidal / Female / Genotype / Homozygote / Humans / Incidence / Male / Neoplasms / PPAR gamma / Polymorphism, Genetic / Risk (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.b14-00160 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24882418 ● CiNii @ 国立情報学研究所 (CRID): 1390282679607989632 ● Summary page in Scopus @ Elsevier: 2-s2.0-84901839094 (DOI: 10.1248/bpb.b14-00160, PubMed: 24882418, CiNii: 1390282679607989632, Elsevier: Scopus)
18.	Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins, Organic & Biomolecular Chemistry, Vol.12, No.23, 3821-3826, 2014. (要約) A traceable linker that is potentially applicable to identification of a target protein of bioactive compounds was developed. It enabled not only thiol-induced cleavage of the linker for enrichment of the target protein but also selective labelling to pick out the target from contaminated non-target proteins for facile identification. (キーワード) Amides / Amino Acids / Click Chemistry / Electrophoresis, Polyacrylamide Gel / Peptides / Proteins / Staining and Labeling / Sulfhydryl Compounds (徳島大学機関リポジトリ) ● Metadata: 111911 (出版サイトへのリンク) ● Publication site (DOI): 10.1039/C4OB00622D (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24806338 ● Summary page in Scopus @ Elsevier: 2-s2.0-84901285801 (徳島大学機関リポジトリ: 111911, DOI: 10.1039/C4OB00622D, PubMed: 24806338, Elsevier: Scopus)
19.	Mai Nagao, Youichi Sato and Aiko Yamauchi : A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer, PLoS ONE, Vol.8, No.8, e71126, 2013. (要約) Several studies have investigated whether the polymorphisms in the prostaglandin endoperoxide synthase 1 (PTGS1) and PTGS2 genes and nonsteroidal anti-inflammatory drug (NSAID) use are associated with cancer risk; however, those studies have produced mixed results. Therefore, we performed a meta-analysis to evaluate the association between the PTGS1 and PTGS2 polymorphisms and the effect of NSAID use on the risk of developing cancer. We conducted a comprehensive search in PubMed through March 2012. The odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated using the fixed-effect model or the random-effect model. The database search generated 13 studies that met the inclusion criteria. For PTGS1 rs3842787, NSAID users homozygous for the major allele (CC) had a significantly decreased cancer risk compared with non-NSAID users (OR = 0.73, 95% CI = 0.59-0.89). For PTGS2 rs5275 and rs20417, there were no significant differences between the gene polymorphism and NSAID use on cancer risk among the 8 and 7 studies, respectively. However, in the stratified analysis by the type of cancer or ethnicity population, NSAID users homozygous for the major allele (TT) in rs5275 demonstrated significantly decreased cancer risk compared with non-NSAID users in cancer type not involving colorectal adenoma (OR = 0.70, 95% CI = 0.59-0.83) and among the USA population (OR = 0.67, 95% CI = 0.56-0.82). NSAID users homozygous for the major allele (GG) in rs20417 displayed a significantly decreased cancer risk than non-NSAID users among the US population (OR = 0.72, 95% CI = 0.58-0.88). For the PTGS2 rs689466 and rs2745557 SNPs, there were no significant differences. This meta-analysis suggests that the associations between PTGS polymorphisms and NSAID use on cancer risk may differ with regard to the type of cancer and nationality. (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0071126 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23967159 ● Search Scopus @ Elsevier (PMID): 23967159 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0071126 (DOI: 10.1371/journal.pone.0071126, PubMed: 23967159)
20.	Youichi Sato, Toshikatsu Shinka, Teruaki Iwamoto, Aiko Yamauchi and Yutaka Nakahori : Y chromosome haplogroup D2* lineage is associated with azoospermia in Japanese males, Biology of Reproduction, Vol.88, No.4, 107, 2013. (要約) Several studies have investigated whether particular Y chromosome haplogroups are associated with spermatogenic failure in Japanese males; however, they produced differing results. In this study, to investigate the association of Y chromosome haplogroup with spermatogenic failure, we recruited 451 infertile patients and 730 fertile men from a Japanese population and typed their Y chromosome haplogroups. The infertile patients were suffering from varicocele, azoospermia, oligozoospermia, asthenozoospermia, obstructive azoospermia, karyotype abnormalities, microdeletions of the long arm of the Y chromosome, or other conditions that affect fertility. The frequency of haplogroup D2* was significantly higher (odds ratio = 2.28, 95% confidence interval = 1.44-3.61, P = 0.00034 using chi-square test) among the men with azoospermia than among the fertile men. None of the other Y haplogroups displayed associations with particular types of infertility. In conclusion, Y chromosome haplogroup D2* is associated with spermatogenic failure in Japanese males, suggesting that the Y chromosome lineage can have significant effects on spermatogenesis. (キーワード) Adult / Asian Continental Ancestry Group / Azoospermia / Case-Control Studies / Cell Lineage / Chromosome Deletion / Chromosomes, Human, Y / DNA Mutational Analysis / Haplotypes / Humans / Japan / Male / Phylogeny / Spermatogenesis (出版サイトへのリンク) ● Publication site (DOI): 10.1095/biolreprod.112.105718 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23467741 ● Search Scopus @ Elsevier (PMID): 23467741 ● Search Scopus @ Elsevier (DOI): 10.1095/biolreprod.112.105718 (DOI: 10.1095/biolreprod.112.105718, PubMed: 23467741)
21.	Youichi Sato, Timothy Jinam, Teruaki Iwamoto, Aiko Yamauchi, Issei Imoto, Ituro Inoue and Atsushi Tajima : Replication study and meta-analysis of human nonobstructive azoospermia in Japanese populations, Biology of Reproduction, Vol.88, No.4, 87, 2013. (要約) Recently, a Chinese genomewide association study (GWAS) identified four autosomal single-nucleotide polymorphism (SNP) loci as being significantly associated with risk factors for nonobstructive azoospermia (NOA; P < 5 × 10(-8)). In the present study, we performed a replication study on two Japanese cohorts from different institutions in order to evaluate whether SNP loci are associated with NOA. The four SNPs (rs12097821, rs2477686, rs10842262, and rs6080550) reported in the Chinese GWAS were genotyped in 490 NOA patients and 1167 controls. To assess the significance of the associations between each of the four SNPs and NOA in the Japanese population, the association results for the two cohorts were combined by meta-analysis. In the meta-analysis, the combined per-allele odds ratios (ORs) for the four SNPs and their respective 95% confidence intervals (CIs) were as follows: rs12097821, OR = 1.10 (CI = 0.89-1.37); rs2477686, OR = 1.11 (CI = 0.87-1.43); rs10842262, OR = 1.11 (CI = 0.94-1.32); and rs6080550, OR = 0.96 (CI = 0.76-1.21). None of the SNPs was significantly associated with NOA (P > 0.05). However, three of four SNPs (rs12097821, rs2477686, and rs10842262) showed associations in the same direction in Japanese men as those reported in the Chinese GWAS. To determine whether the four SNPs are genetic risk factors for NOA, the effect sizes of NOA risk factors require further investigation using larger independent sets of case-control samples of populations, including Japanese and Chinese populations. (キーワード) Adult / Asian Continental Ancestry Group / Azoospermia / Case-Control Studies / Cohort Studies / Gene Frequency / Genome-Wide Association Study / Genotype / Humans / Japan / Male / Polymorphism, Single Nucleotide (出版サイトへのリンク) ● Publication site (DOI): 10.1095/biolreprod.112.106377 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23467743 ● Search Scopus @ Elsevier (PMID): 23467743 ● Search Scopus @ Elsevier (DOI): 10.1095/biolreprod.112.106377 (DOI: 10.1095/biolreprod.112.106377, PubMed: 23467743)
22.	坂東志津子, 高橋正志, 松下明, 山内あい子 : 地域薬局薬剤師による糖尿病自己管理支援におけるポートフォリオ活用の試み, 日本ファーマシューティカルコミュニケーション学会会誌, Vol.10, No.2, 4-15, 2012年.
23.	Shizuko Bando, Masashi Takahashi and Aiko Yamauchi : A Questionnaire Survey on Medication Adherence at a Community Pharmacy in Okayama to Determine the Requirements for Pharmaceutical Care, Japanese Journal of Pharmaceutical Health Care and Sciences, Vol.38, No.5, 304-312, 2012. (出版サイトへのリンク) ● Publication site (DOI): 10.5649/jjphcs.38.304 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.5649/jjphcs.38.304 (DOI: 10.5649/jjphcs.38.304)
24.	Yujiro Morioka, Masuhiro Nishimura, Hiroaki Takehara, Kazuhisa Doi, Shinsaku Naito and Aiko Yamauchi : Intrathecal Disposition of ARTCEREB® Irrigation and Perfusion Solution for Cerebrospinal Surgery in Rats, Biological & Pharmaceutical Bulletin, Vol.34, No.5, 688-692, 2011. (要約) We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35 ml/kg/h, taking into consideration the clinical perfusion rate (500 ml/60 kg/d). The influence of Artcereb on electrolytes in cerebrospinal fluid (CSF) and blood were then investigated. After 24 h of ventriculocisternal perfusion with Artcereb using the push-pull method, output of K(+), Na(+) and Cl(-) to the cistern magna was very similar to input of these electrolytes in Artcereb infused intraventricularly. Recovery rates of K(+), Na(+) and Cl(-) after perfusion were 102%, 105% and 100% when calculated using the recovered perfusion solution. In addition, concentrations of K(+), Na(+) and Cl(-) in blood remained almost constant at near baseline levels throughout perfusion. Thus, intrathecally perfused Artcereb did not affect electrolyte balance in the CSF and blood. To confirm the dynamics of Artcereb distribution, a whole body autoradiography study was performed at 1 and 6 h after perfusion with ¹ C-inulin-added Artcereb. Radioactivity was detected in the entire CSF space of the brain, and the cribriform plate in the nasal cavity, and the cerebrospinal cavity. Radioactivity was observed in the bladder, thus suggesting that some ¹ C-inulin was transferred to the bloodstream via a physiological route, and was excreted renally. (キーワード) Animals / 中枢神経系 (central nervous system) / 男性 (male) / Perfusion / Rats / Rats, Sprague-Dawley / 脊椎 (spine) / Therapeutic Irrigation (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.34.688 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21532158 ● Search Scopus @ Elsevier (PMID): 21532158 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.34.688 (DOI: 10.1248/bpb.34.688, PubMed: 21532158)
25.	Masuhiro Nishimura, Kazuhisa Doi, Sanae Kishimoto, Osamu Koshitani, Shinsaku Naito and Aiko Yamauchi : Pharmacological assessment of ARTCEREB® irrigation and perfusion solution for cerebrospinal surgery using primary cultures of rat brain cells, The Journal of Toxicological Sciences, Vol.35, No.4, 447-457, 2010. (要約) ARTCEREB irrigation and perfusion solution (Artcereb), an ethical pharmaceutical, is typically applied inside the skull and spinal cavity as artificial fluid. Artcereb is composed of glucose and electrolytes (Na+, K+, Mg2+, Ca2+, Cl-, HCO3- and P) and has a pH of 7.3. An in vitro assessment of the effects of Artcereb on cell culture of rat fetal astrocytes or rat fetal brain cells was performed in comparison with normal saline and lactated Ringer's solutions. Furthermore, the effects of Artcereb on cell culture of rat fetal brain cells were also assessed in comparison with Krebs bicarbonate solution. Cell function after exposure to Artcereb was assessed based on 3H-thymidine incorporation activity. Cell function after exposure to Artcereb and lactated Ringer's solution in primary cultures of rat fetal astrocytes remained unaffected when compared to that after exposure to normal saline. Cell function after exposure to Artcereb in a primary culture of rat brain cells remained unaffected as compared to that after exposure to normal saline and lactated Ringer's solution. However, function decreased after exposure to a modified Artcereb formulation lacking bicarbonate, thus confirming that the presence of bicarbonate is essential for the Artcereb formulation. (キーワード) Animals / Astrocytes / Bicarbonates / 脳 (brain) / Cell Culture Techniques / Cerebrospinal Fluid / Electrolytes / 女性 (female) / Fetus / グルコース (glucose) / Perfusion / Pharmaceutical Solutions / Rats / Rats, Sprague-Dawley / Sodium Chloride / Solutions / Therapeutic Irrigation (出版サイトへのリンク) ● Publication site (DOI): 10.2131/jts.35.447 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20686331 ● Search Scopus @ Elsevier (PMID): 20686331 ● Search Scopus @ Elsevier (DOI): 10.2131/jts.35.447 (DOI: 10.2131/jts.35.447, PubMed: 20686331)
26.	Hiroaki Yanagawa, Junji Terao, Eiji Takeda, Yoshihisa Takaishi, Yoshiki Kashiwada, Kazuyoshi Kawazoe, Fushitani Shuji, Koichiro Tsuchiya, Aiko Yamauchi, Sato Chiho and Minoru Irahara : Consultation clinics for complementary and alternative medicine at Japanese university hospitals: An analysis at Tokushima University Hospital, Experimental and Therapeutic Medicine, Vol.1, No.3, 481-483, 2010. (要約) Here, we report on a Consultation Clinic for Complementary and Alternative Medicine (CAM) which we established at Tokushima University Hospital in July of 2007 with the aim of providing person-to-person information on CAM, though not CAM therapy itself. In December of 2008, we received 55 applications for consultation, 37% concerning health foods, 37% Japanese herbal medicine (Kampo), and 26% various other topics. The consultants (nutritionists and pharmacists) communicated individually with 38 applicants; malignancies (26%) and cardiovascular disease (24%) were the main underlying concerns. To promote the quality of consultation, data was collected by means of focus group interviews concerning the perspective of the consultants. Safe and effective use of CAM requires a network of communication linking individuals, consultation teams, physicians, primary care institutions and university hospitals. To advance this goal, we plan to broaden the efforts described herein. Our findings indicate that the specific role of the consultation clinic in promoting the scientific use of CAM merits further study. (出版サイトへのリンク) ● Publication site (DOI): 10.3892/etm_00000075 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22993564 ● Search Scopus @ Elsevier (PMID): 22993564 ● Search Scopus @ Elsevier (DOI): 10.3892/etm_00000075 (DOI: 10.3892/etm_00000075, PubMed: 22993564)
27.	Doi Kazuhisa, Morioka Yujiro, Nishimura Masuhiro, Kawano Takeshi, Harada Daisuke, Naito Shinsaku and Aiko Yamauchi : Perfusion fluids used in neurosurgery affect cerebrospinal fluid and surrounding brain parenchyma in the rat ventriculocisternal perfusion model, The Journal of Toxicological Sciences, Vol.34, No.5, 511-518, 2009. (要約) ARTCEREB, an irrigation and perfusion solution (Artcereb), is a preparation intended for the irrigation and perfusion of the cerebral ventricles, and it is therefore important to evaluate its effects on cerebrospinal fluid (CSF) and on the surrounding cerebrospinal parenchyma. To confirm the kinetics of the perfusion fluid component, we performed whole body autoradiography and examined glucose balance during ventriculocisternal perfusion with (14)C-glucose labeled Artcereb in the rat model, which simulates ventricular irrigation or ventriculocisternal perfusion in clinical neurosurgery. We also performed ventriculocisternal perfusion with Artcereb, lactated Ringer's solution, or normal saline, and observed the effect of these solutions on animal condition and on brain tissue morphology. In the kinetic study, diffusion of (14)C-glucose from the perfused Artcereb to the cerebrospinal tissue was seen on whole body autoradiography, and almost 90% of the glucose in the perfusion fluid was distributed to the cerebrospinal tissue and the systemic circulation. These data indicated that the perfusion fluid interacted actively with the CSF, surrounding parenchyma and the systemic circulation, and suggested that the formation of perfusion fluid affected CSF composition and cerebrospinal tissue functions. Animals perfused with normal saline were associated with serious symptoms including tonic convulsions and death, and exhibited neuronal death in the cerebrum. However, these severe changes were not observed in animals perfused with Artcereb or lactated Ringer's solution. We therefore propose that during neurosurgery, it is extremely important to use a physiological solution like Artcereb which closely resembles normal human CSF, in order to maintain cerebrospinal function and to alleviate postoperative adverse events. (キーワード) Animals / Autoradiography / 脳 (brain) / Cerebral Ventricles / Cerebrospinal Fluid / Cisterna Magna / グルコース (glucose) / Isotonic Solutions / Models, Animal / Perfusion / Pharmaceutical Solutions / Rats / Rats, Sprague-Dawley (出版サイトへのリンク) ● Publication site (DOI): 10.2131/jts.34.511 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19797859 ● Search Scopus @ Elsevier (PMID): 19797859 ● Search Scopus @ Elsevier (DOI): 10.2131/jts.34.511 (DOI: 10.2131/jts.34.511, PubMed: 19797859)
28.	西村益浩, 土居和久, 榎本理世, 李英培, 内藤真策, 山内あい子 : アートセレブ®脳脊髄手術用洗浄灌流液:ヒトアストロサイト培養系を用いた薬理学的評価, 薬学雑誌, Vol.129, No.9, 1121-1126, 2009年. (要約) ARTCEREB® irrigation and perfusion solution (Artcereb) is a preparation intended for the irrigation and perfusion of the cerebral ventricles, and it is therefore important to evaluate the effects of Artcereb on brain cells. In vitro assessment of the effects of Artcereb in cell cultures of human fetal astrocytes was conducted in comparison with normal saline and lactated Ringers solution. The effects of exposure to Artcereb were evaluated based on microscopic images of the mitochondria stained with rhodamine 123. The effects of exposure to Artcereb on cell function were also evaluated by quantitative analysis of mitochondrial activity based on rhodamine 123 and 3H-thymidine incorporation. Morphological changes in nuclear structure were also evaluated. The results of the present study showed that cell function in cell cultures of human astrocytes was relatively unaffected by exposure to Artcereb as compared with normal saline or lactated Ringers solution, suggesting that Artcereb has less effect on brain cells than normal saline or lactated Ringers solution when used for the irrigation or perfusion of the cerebral ventricles. (キーワード) ARTCEREB® / cerebrospinal surgery / irrigation solution / perfusion solution / human astrocytes (出版サイトへのリンク) ● Publication site (DOI): 10.1248/yakushi.129.1121 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206127565696 ● Search Scopus @ Elsevier (DOI): 10.1248/yakushi.129.1121 (DOI: 10.1248/yakushi.129.1121, CiNii: 1390001206127565696)
29.	Miyuki Ikeuchi, Masako Ikuta, Miyuki Hariki, Motoki Ikeuchi, Shigeki Muruyama, Mari Nakase, Kumiko Sakamoto, Yasuko Yoshioka, Aiko Yamauchi and Masaru Kihara : Synthesis and Pharmacological Evaluation of New 1-Hydroxy-1-phenyl-2, 3,4, 5-tetrahydro-1H-3-benzazepines as NE Potentiators, Chemical & Pharmaceutical Bulletin, Vol.57, No.5, 443-445, 2009. (要約) 4-Hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (PI-OH) (1a) and its derivatives form a new class of compounds which possess norepinephrine (NE) potentiating activity. As a new series of compounds, 1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines (2a--f) were synthesized by the intramolecular Barbier reaction of N-[2-(2-iodophenyl)ethyl]phenacylamines (6a--f) with n-BuLi as a key reaction step. The potentiating activities of the benzazepines 2a--f on the contraction of rat anococcygeus muscle induced by NE were tested. Among the compounds tested in this study, compound 2a showed moderate potentiating activity (the activity ratio was 7.3-fold at 3 x 10(-5) M). (キーワード) Animals / Benzazepines / Drug Synergism / 分子構造 (molecular structure) / Muscle Contraction / 平滑筋 (smooth muscle) / Norepinephrine / Rats / Vasoconstrictor Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1248/cpb.57.443 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19420772 ● Summary page in Scopus @ Elsevier: 2-s2.0-65949085140 (DOI: 10.1248/cpb.57.443, PubMed: 19420772, Elsevier: Scopus)
30.	Daisuke Itokawa, Aiko Yamauchi and Hiroshi Chuman : Quantitative Structure-Activity Relationship for Inhibition of CYP2B6 and CYP3A4 by Azole Compounds - Comparison with Their Binding Affinity, QSAR & Combinatorial Science, Vol.28, No.6-7, 629-639, 2009. (キーワード) Azole / Bilinear model using log P / Binding affinity / Cytochrome P450 / Inhibitory activity / CYTOCHROMES P450 / 乳癌 (breast cancer) / 代謝 (metabolism) / ENZYMES (出版サイトへのリンク) ● Publication site (DOI): 10.1002/qsar.200730115 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-67949094415 (DOI: 10.1002/qsar.200730115, Elsevier: Scopus)
31.	山内あい子, 坂本久美子, 中田栄子, 佐々木幹夫, 谷真琴, 中馬寛 : 医薬品安全性情報コミュニティ·データベースシステム:妊娠と薬に関する安全性情報の共有に向けて, 情報管理, Vol.50, No.3, 135-143, 2007年.
32.	Tomoo Aoyama, Junko Kambe, Aiko Yamauchi and Umpei Nagashima : Construction of a model for water purification mechanisms in a river by using a neural network approach, Journal of Computer Chemistry, Japan, Vol.6, No.2, 135-144, 2007. (要約) A model for purification mechanisms in a river was proposed to express changes in the values of BOD (Biochemical Oxygen Demand), COD (Chemical Oxygen Demand), T-N (Total Nitrogen), and T-P (Total Phosphorous) as the combination of inflows, streams, and weirs. Because expressions for these functions are unknown, the model first constructs multi-layer neural-network functions based on observations, and then uses the derivatives to evaluate the cause and effect of pollution.For data of the Tamagawa through Tokyo, Japan in 2002, the model suggested that the cause of pollution is inflows from sewage, the stream of the Tamagawa has purification functions for COD and T-P, but has little ability for T-N, and the weirs have purification for COD, but have no purification for T-N and T-P. The results from the model were consistent with common sense for the water quality, and thus, there was no failure in the model. (キーワード) River Model / Water Purification / ニューラルネットワーク (neural network) / Derivatives / River Model / Water Purification / Derivatives (出版サイトへのリンク) ● Publication site (DOI): 10.2477/jccj.6.135 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205181413376 ● Search Scopus @ Elsevier (DOI): 10.2477/jccj.6.135 (DOI: 10.2477/jccj.6.135, CiNii: 1390001205181413376)
33.	Kumiko Sakamoto, Yuki Hibino, Masaru Kihara, Shuji Yamano, Kazuhisa Maeda, Minoru Irahara and Aiko Yamauchi : Prescribing patterns during pregnancy at Tokushima University Hospital, Japanese Journal of Pharmaceutical Health Care and Sciences, Vol.33, No.4, 377-385, 2007. (要約) The purpose of this study was to investigate the drugs prescribed for pregnant women at Tokushima University Hospital in Japan, and to evaluate the risks associated with the use of these drugs during pregnancy according to the pregnancy risk classification systems of the PDA, ADEC and that used in manufacturers' package inserts. Of 496 female outpatients who gave birth at Tokushima University Hospital, 81% had been prescribed at least one drug, and the mean was 4.0 drugs per patient. Analysis of the prescriptions revealed a pattern of drug use very different from that in other countries, in that Kampo (Japanese herbal) medicines were also prescribed. For more than half of the oral drugs prescribed, risks were not given in the PDA and/or ADEC pregnancy risk systems. In addition, there was no listing of pregnancy risks in the package inserts of 20 drugs. We therefore consider it to be very important to develop a globally harmonized system for evaluating the risks associated with prescription drugs taken during pregnancy. (キーワード) pregnancy / medication / prescription patterns / risk classification (出版サイトへのリンク) ● Publication site (DOI): 10.5649/jjphcs.33.377 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204775485440 ● Search Scopus @ Elsevier (DOI): 10.5649/jjphcs.33.377 (DOI: 10.5649/jjphcs.33.377, CiNii: 1390001204775485440)
34.	Kumiko Sakamoto, Aiko Yamauchi, Mikio Sasaki and Hiroshi Chuman : A structural similarity evaluation by SimScore in a teratogenicity information sharing system, Journal of Computer Chemistry, Japan, Vol.6, No.2, 117-122, 2007. (要約) Many efforts have been devoted to the development of computer-aided prediction of drug toxicity over the decades, but at present, systems and programs available for predicting teratogenicity from chemical structures do not always give satisfactory answers yet, mainly because of the complex and unknown mechanism of reproductive and developmental toxicity. We developed a novel algorithm and implemented in the program "SimScore" to evaluate quantitatively the structural similarity score of a target compound with the teratogenic drugs which are defined as serious human teratogens by the United States Food and Drug Administration. In SimScore, a molecular structure is divided into its skeletal and substituent parts in order to perform similarity comparison for these parts independently. This idea is based on that compounds with the same or similar skeleton show a similar biological activity, but their activity strengths depend on the variation of substituents. We demonstrated the usefulness of SimScore by applying it to an example.SimScore will be used in our web-based information system about teratogenicity to predict the potential risk of query compounds. (キーワード) SimScore / Structural similarity matching / Teratogenic toxicity prediction / Teratogenicity information sharing system / Molecular structural information (出版サイトへのリンク) ● Publication site (DOI): 10.2477/jccj.6.117 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205178426880 ● Search Scopus @ Elsevier (DOI): 10.2477/jccj.6.117 (DOI: 10.2477/jccj.6.117, CiNii: 1390001205178426880)
35.	神部順子, 長嶋雲兵, 山内あい子 : ニューラルネットワークを用いたドナウ川の水質解析-OECDレポートを用いて-, Journal of Computer Chemistry, Japan, Vol.6, No.2, 91-102, 2007年. (要約) OECDによるドナウ川の水質データの経年変化に関し，欠測データを含むデータの解析が可能な多階層型ニューラルネットワークシミュレーション(CQSAR)法を用いて，欧州の河川再自然化政策等による河川の水質浄化の有効性およびダム建設の影響を検討した．ドイツ圏で施行されている河川再自然化や水質浄化政策はT-P値の改善にはあまり効果がなかったが，DO,BOD値を改善していた．特に，ドナウ川のハンガリー流域でのBOD値に浄化傾向がみられた．ドナウ川のBOD値から自然浄化作用が河川浄化策の施行により回復してきていると判断できた．スロヴァキアとハンガリー間のドナウ川に設けられたダム(ガブチコボ・ナジュマロシュ・ダム)の影響は，DO値は悪化される傾向にあり，逆にBOD値は改善される傾向にあった．また，ダム建設によりダム下流のドナウ川のハンガリー流域でのDO値やBOD値が，ダム上流域の水質と関係しなくなったことが明らかになった． (キーワード) Compensation Quantitative Structure-Activity Relationship (CQSAR) / Water quality / Donau / Re-naturalization / Compensation Quantitative Structure-Activity Relationship (CQSAR) (出版サイトへのリンク) ● Publication site (DOI): 10.2477/jccj.6.91 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205181414656 ● Search Scopus @ Elsevier (DOI): 10.2477/jccj.6.91 (DOI: 10.2477/jccj.6.91, CiNii: 1390001205181414656)
36.	Junko Kambe, Tomoo Aoyama, Aiko Yamauchi and Umpei Nagashima : Extraction of a parameter as an index to assess water quality of the Tamagawa, Tokyo, Japan, by using neural networks and multivariate analysis, Journal of Computer Chemistry, Japan, Vol.6, No.1, 19-26, 2007. (要約) Parameters as an index to efficiently assess the pollution level of the upper, middle, and lower streams of the Tamagawa (Tokyo, Japan) based on measured water quality were determined by using multivariate analysis, principal component analysis (PCA), and cluster analysis (CA) for data measured from 1994 to 2002. Missing data during 2000-2002 were estimated using a perceptron type neural network and arithmetic progression. The combination of scores for the first and second principal components obtained by PCA enabled classification of the upper, middle, and lower streams of the Tamagawa. The CA results corresponded well with the PCA results. Based on the score of the first principal compornent determined here, contributions to the water pollution of the middle and lower streams should be decreased to improve the water quality of the Tamagawa. (キーワード) Tamagawa / Principal Component Analysis / Cluster Analysis / Water Contamination / Chemometrics / Tamagawa / Principal Component Analysis / Cluster Analysis / Water Contamination / Chemometrics (出版サイトへのリンク) ● Publication site (DOI): 10.2477/jccj.6.19 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205179333888 ● Search Scopus @ Elsevier (DOI): 10.2477/jccj.6.19 (DOI: 10.2477/jccj.6.19, CiNii: 1390001205179333888)
37.	神部順子, 青山智夫, 山内あい子, 長嶋雲兵 : 線形多変量解析を用いた徳島吉野川の水質の解析, Journal of Computer Chemistry, Japan, Vol.6, No.1, 1-18, 2007年. (要約) 吉野川の水質浄化の指針を得るために，吉野川水系の上流から河口に至るまでの5種類の水質パラメータの変化を主成分分析とクラスター分析を用いて解析し，吉野川水系の上流から下流までの汚染度をみるための複合的な指標を得ることを試みた．吉野川の汚染の傾向を見るためには，少なくとも5つのパラメータほぼ同じ程度重要であった．吉野川は4つの河口を持つ(Figure 1)が，水質は河口からの距離とは対応しておらず(Table 5)，最も河口からの距離が長い平和橋(銅山川)と河口の1つである新町川の水質汚染が進んでいることがわかった(Figure 6，Table 12)．このことから，それぞれの流域の水質に影響を与えている要因を個々に探る必要があることが示唆された．吉野川の水質浄化のためには，このような要因の解析と総合的な環境指標に基づいた解析が重要であることがわかった． (キーワード) Water Pollution / Yoshinogawa River / Chemometrics / Principal Component Analysis / Cluster Analysis / Water Pollution / Yoshinogawa River / Chemometrics / Principal Component Analysis / Cluster Analysis (出版サイトへのリンク) ● Publication site (DOI): 10.2477/jccj.6.1 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680156045696 ● Search Scopus @ Elsevier (DOI): 10.2477/jccj.6.1 (DOI: 10.2477/jccj.6.1, CiNii: 1390282680156045696)
38.	Daisuke Itokawa, Tomoki Nishioka, Junji Fukushima, Tomoyo Yasuda, Aiko Yamauchi and Hiroshi Chuman : Quantitative structure - activity relationship study of binding affinity of azole compounds with CYP2B and CYP3A, QSAR & Combinatorial Science, Vol.26, No.7, 828-836, 2007. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/qsar.200610136 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-34547158029 (DOI: 10.1002/qsar.200610136, Elsevier: Scopus)
39.	坂本久美子, 神部順子, 中田栄子, 佐々木幹夫, 中馬寛, 山内あい子 : 「妊娠と薬」に関する意識調査-薬剤師, 薬学生, 研究者の場合, 医療薬学, Vol.32, No.9, 956-963, 2006年. (要約) The aim of this study was to assess the awareness of pharmacists, pharmacy students and researchers regarding "Drugs and Pregnancy". In order to do this, a questionnaire was given to 211 attendees of a symposium held under a pharmacists' education program held at the University of Tokushima. The response rate was 108/211 (51%) and the breakdown of the respondents was students 46%, pharmacists 36% and researchers 9%. Among the 36 persons with experience of delivery, 67% had taken medicine during pregnancy, and 42% of them were worried about the embryotoxic effects of drugs. Persons with no experience of delivery were more worried about such effects than those who had experienced delivery. Before being given a prescription, 71% of the respondents had been asked about the possibility of pregnancy by a physician. On the other hand, no respondent had been asked about this by a pharmacist, suggesting that pharmacists are passive with regard to providing information about drugs and pregnancy. Information on drugs and pregnancy was mainly obtained from drug package inserts, books and pharmaceutical companies. The majority of the respondents (96%) were interested in a web site from which they could retrieve information on drug safety during pregnancy. They showed a willingness to cooperate with regard to recording medicines used during the pregnancy as well as the outcome of their pregnancies. Eighty-nine percent of the researchers and 78% of the students wanted to use teratogenicity information in drug design. All of the researchers answered that it was beneficial to share information on reproductive and developmental toxicity. The results of our questionnaire survey showed that many people desired drug safety information during pregnancy, and were willing to share such information. (キーワード) questionnaire survey / drugs and pregnancy / drug safety information community / pharmacists / pharmacy students / researchers (出版サイトへのリンク) ● Publication site (DOI): 10.5649/jjphcs.32.956 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204775727232 ● Search Scopus @ Elsevier (DOI): 10.5649/jjphcs.32.956 (DOI: 10.5649/jjphcs.32.956, CiNii: 1390001204775727232)
40.	Eiko Nakata Doolin, Takao Orii, Kenichirou Sakakibara, Takehiko Yasumizu and Aiko Yamauchi : Effect of advanced pharmaceutical services for chemotherapy on length of hospital stay, Japanese Journal of Pharmaceutical Health Care and Sciences, Vol.32, No.8, 849-856, 2006. (要約) We prepared a chemotherapy information leaflet that helped to enhance patients' understanding of chemotherapy and to reduce their anxiety about its adverse reactions. The aim of the present study was to evaluate pharmaceutical services with regard to the management of adverse reactions, length of hospital stay and the medical costs for women with gynecologic cancer who received chemotherapy. We carried out a retrospective chart survey of 28 ovarian cancer patients to clarify the effects of pharmaceutical care on their chemotherapy. Half of the patients were given chemotherapy information verbally and were assigned to Group A, and the other half were supplied with an information leaflet and a self-check list for adverse reactions and assigned to Group B. There were no significant differences between the two groups regarding the occurrence of adverse events, except for fatigue and insomnia. However, 50% (7/14) of the patients in Group A stayed longer in hospital to be free from adverse reactions, especially myelosuppression. The mean hospital days per cycle of chemotherapy in Group B (2.76±0.80 days) was significantly shorter than that in Group A (7.28±3.97 days, p<0.001). Thus, our pharmaceutical care using chemotherapy information leaflets had a favorable effect in terms of shortening the length of hospital stay. (キーワード) chemotherapy information leaflet / retrospective chart survey / ovarian cancer / hospital stay / pharmaceutical care (出版サイトへのリンク) ● Publication site (DOI): 10.5649/jjphcs.32.849 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679752055936 ● Search Scopus @ Elsevier (DOI): 10.5649/jjphcs.32.849 (DOI: 10.5649/jjphcs.32.849, CiNii: 1390282679752055936)
41.	Kumiko Sakamoto, Yuki Hibino, Shuji Yamano, Kazuhisa Maeda, Minoru Irahara and Aiko Yamauchi : Prescription drug use during pregnancy in Japan, Reproductive Toxicology, Vol.22, No.2, 283, 2006.
42.	Masuhiro Nishimura, Mari Yamaguchi, Shinsaku Naito and Aiko Yamauchi : Soybean oil fat emulsion to prevent TPN-induced liver damage:Possible molecular mechanism and clinical implications, Biological & Pharmaceutical Bulletin, Vol.29, No.5, 855-862, 2006. (要約) Long-term total parenteral nutrition (TPN) is known to be associated with cholestasis and hepatic steatosis, which can be lethal in infants who cannot be fed orally. The present review focuses on the metabolic complications in the liver that may occur due to the excessive administration of fat-free TPN. We have recently developed an infant rat model of hepatic dysfunction and steatosis induced by overdose of fat-free TPN. In this model, plasma levels of liver enzymes in the fat-free TPN group were found to be significantly higher than in the other groups (i.e., the oral diet and fat-containing TPN groups). Pathological examination showed hepatomegaly and severe fatty changes without cholestasis in the liver of infant rats that received fat-free TPN. We clearly demonstrated that the addition of soybean oil emulsion to the TPN regimen prevented hepatic dysfunction and fatty changes. In the present review, we discuss the molecular mechanism of the hepatic dysfunction induced by fat-free TPN and the role of soybean oil fat emulsion in the TPN regimen. We also discuss the clinical implications of soybean oil-containing TPN solutions and point out the importance of including fat in the TPN regimen in order to prevent the hepatic abnormalities associated with the excessive administration of fat-free TPN. (キーワード) Animals / Antioxidants / Carrier Proteins / Cholestasis / Cytochrome P-450 Enzyme System / Down-Regulation / Drug-Induced Liver Injury / Fatty Acids / Humans / Parenteral Nutrition, Total / Rats / Soybean Oil (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.29.855 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16651709 ● Search Scopus @ Elsevier (PMID): 16651709 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.29.855 (DOI: 10.1248/bpb.29.855, PubMed: 16651709)
43.	山内あい子, 坂本久美子, 日比野有紀, 中馬寛, 苛原稔 : 妊娠期の薬物療法∼その実態と母児への影響∼, 性差と医療, Vol.3, No.5, 27(521)-32(526), 2006年.
44.	Motoki Ikeuchi, Miyuki Ikeuchi, Kumiko Inoue, Syuhei Yamamoto, Aiko Yamauchi and Masaru Kihara : A new synthesis of phenolic 1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, Heterocycles, Vol.65, No.12, 2925-2935, 2005. (キーワード) 3-Benzazepine / Phenolic Benzazepine / Intramolecular Barbier Reaction / Cyclization / N-Phenethylphenacylamine (出版サイトへのリンク) ● Publication site (DOI): 10.3987/COM-05-10554 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520573330104412928 ● Summary page in Scopus @ Elsevier: 2-s2.0-33646881945 (DOI: 10.3987/COM-05-10554, CiNii: 1520573330104412928, Elsevier: Scopus)
45.	Xiangli Liu, Hideji TANAKA, Aiko Yamauchi, Bernard Testa and Hiroshi Chuman : Determination of lipophilicity by reversed-phase high-performance liquid chromatography: Influence of 1-octanol in the mobile phase, Journal of Chromatography. A, Vol.1091, No.1-2, 51-59, 2005. (要約) Lipophilicity was evaluated using a novel RP-HPLC stationary phase (Discovery-RP-Amide-C16) with and without 1-octanol added to the mobile phase. A set of 46 drugs and flavonoids characterized by a broad structural diversity and a wide log Poct range (-0.69 to 5.70) was selected for this study. This set consists of neutral solutes and solutes with acidic or ampholytic functionalities which were maintained neutral at pH 2.5 or 4. In our conditions, the addition of 1-octanol in the mobile phase proved a key factor to derive a lipophilicity index log k(w) highly correlated with log Poct for all investigated solutes. 1-Octanol improved the correlation between log Poct and log k(w) mainly by influencing the retention behavior of the solutes with log Poct values below +3. This study brings additional evidence that under proper experimental conditions of stationary and mobile phases, RP-HPLC is a very useful method to obtain log Poct values. (キーワード) Lipophilicity / log Poct / log kw / Mobile phase / Stationary phase / 1-Octanol / LC (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.chroma.2005.07.029 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16395792 ● Search Scopus @ Elsevier (PMID): 16395792 ● Search Scopus @ Elsevier (DOI): 10.1016/j.chroma.2005.07.029 (DOI: 10.1016/j.chroma.2005.07.029, PubMed: 16395792)
46.	Aiko Yamauchi, Kumiko Sakamoto and Hiroshi Chuman : Clinical QSAR study on the prediction of drug excretion into human breast milk, Drug Metabolism Reviews, Vol.37, No.suppl2, 330-331, 2005.
47.	Masuhiro Nishimura, Aiko Yamauchi, Mari Yamaguchi, Sanae Kishimoto, Nobuhiko Ueda and Sinsaku Naito : Major role of soybean oil in preventing decrease in CYP4A1 mRNA content relative to PPARαmRNA down-regulation in infant rats, Biological & Pharmaceutical Bulletin, Vol.28, No.8, 1517-1520, 2005. (要約) Changes in the levels of CYP4A1, PPARalpha, and RXRalpha mRNA expression in the liver following overdose of fat-free or fat-containing total parenteral nutrition (TPN) were studied in 3-week-old male Sprague-Dawley rats. The rats were divided into three groups: group 1, oral diet; group 2, fat-free TPN; and group 3, TPN with 20% of calories from soybean oil emulsion. Levels of CYP4A1, PPARalpha, and RXRalpha mRNA in the fat-free TPN group were significantly lower than those in the other groups. Levels of CYP4A1 and PPARalpha mRNA were strongly correlated (r=0.849), and levels of CYP4A1 and RXRalpha mRNA were weakly correlated (r=0.618). This is the first report of a strong correlation between the levels of CYP4A1 and PPARalpha mRNA following overdose of fat-free or fat-containing TPN in infant rats. Our results also indicate that it is important to include fat in TPN regimens in order to prevent CYP4A1 mRNA down-regulation, which may be related to changes in PPARalpha mRNA levels in the liver. (キーワード) Animals / Base Sequence / Cytochrome P-450 Enzyme System / DNA Primers / Down-Regulation / Male / PPAR alpha / RNA, Messenger / Rats / Rats, Sprague-Dawley / Retinoid X Receptor alpha / Reverse Transcriptase Polymerase Chain Reaction / Soybean Oil (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.28.1517 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16079505 ● Search Scopus @ Elsevier (PMID): 16079505 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.28.1517 (DOI: 10.1248/bpb.28.1517, PubMed: 16079505)
48.	Masuhiro Nishimura, Aiko Yamauchi, Mari Yamaguchi, Nobuhiko Ueda and Sinsaku Naito : Soybean oil in total parenteral nutrition maintains albumin and antioxidant enzyme mRNA levels, Biological & Pharmaceutical Bulletin, Vol.28, No.7, 1265-1269, 2005. (要約) Changes in albumin and antioxidant enzyme mRNA expression in infant rat liver following administration of total parenteral nutrition (TPN) with/without soybean oil emulsion were studied. Infant rats were divided into three groups: group 1=oral diet, group 2=TPN without fat, and group 3=TPN with 20% of calories from soybean oil emulsion. The period of TPN administration was 4 d. Serum aspartate aminotransferase and alanine aminotransferase levels were higher in group 2 than in the other groups, with similar levels seen in the other groups. Albumin, Cu, Zn-superoxide dismutase, and glutaredoxin 1 mRNA expression levels were lower in group 2 than in the other groups, with similar levels seen in the other groups. Catalase mRNA expression was higher in group 1 than in the other groups, with the lowest level seen in group 2. Soybean oil emulsion should be included in TPN regimens to prevent down-regulation of albumin and antioxidant enzyme mRNA expression. (キーワード) Albumins / Animals / Base Sequence / DNA Primers / Glutaredoxins / Liver / Male / Oxidoreductases / Parenteral Nutrition, Total / RNA, Messenger / Rats / Rats, Sprague-Dawley / Reverse Transcriptase Polymerase Chain Reaction / Soybean Oil / Superoxide Dismutase (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.28.1265 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15997111 ● Search Scopus @ Elsevier (PMID): 15997111 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.28.1265 (DOI: 10.1248/bpb.28.1265, PubMed: 15997111)
49.	Kenji Ikuta, Kazu Takemura, Masaru Kihara, Shinsaku Naito, Eibai Lee, Eiji Shimizu and Aiko Yamauchi : Defects in apoptotic signal transduction in cisplatin-resistant non-small cell lung cancer cells, Oncology Reports, Vol.13, No.6, 1229-1234, 2005. (要約) Non-small cell lung cancer (NSCLC) often shows intrinsic multidrug resistance, which is one of the most serious problems in cisplatin-based adjuvant chemotherapy. Anticancer drugs exert at least part of their cytotoxic effect by triggering apoptosis. In order to understand the molecular alterations leading to heterogeneous cisplatin sensitivity and apoptosis inducibility in NSCLC cells, we analyzed various apoptotic pathways, including the activation of caspase-8, -9 and -3, the release of cytochrome c from mitochondria and the expression levels of pro- and anti-apoptotic proteins such as Bax, Bad, Bcl-2, Bcl-xL, Fas and p53 using heterogeneously apoptosis-sensitive cells (Ma-10, Ma-31 and Ma-46). Cisplatin treatment induced the activation of caspase-8, -9 and -3 and the release of cytochrome c in apoptosis-sensitive Ma-46. The expression of Bcl-xL was the highest and p53 was not expressed in apoptosis-resistant Ma-31, and Fas was not expressed in Ma-46. These expression levels were not correlated with the apoptosis inducibility of the three cell lines. These results suggest that blockage of the apoptotic signal from mitochondria is responsible for apoptosis resistance in NSCLC cell lines. Our findings also indicate that anti-apoptotic Bcl-xL and pro-apoptotic p53 are necessary but not sufficient for resistance to cisplatin-induced apoptosis in NSCLC cells. (キーワード) Antigens, CD95 / Antineoplastic Agents / アポトーシス (apoptosis) / Carcinoma, Non-Small-Cell Lung / Caspases / Cisplatin / Cytochromes c / Drug Resistance, Neoplasm / Enzyme Activation / Humans / Lung Neoplasms / ミトコンドリア (mitochondria) / Proto-Oncogene Proteins c-bcl-2 / シグナル伝達 (signal transduction) / Tumor Cells, Cultured / Tumor Suppressor Protein p53 / bcl-2-Associated X Protein (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15870947 ● Search Scopus @ Elsevier (PMID): 15870947 (PubMed: 15870947)
50.	生田雅子, 会田真規, 石澤啓介, 水口和生, 土屋浩一郎, 木原勝, 山内あい子 : 徳島大学病院におけるTPN処方設計支援ソフトの使用評価と改良, 医療薬学, Vol.31, No.4, 279-286, 2005年. (要約) Fluid therapy is a fundamental treatment for almost all inpatients, and nutritional therapy is the most important type of such therapy. Currently, total parenteral nutrition (TPN) is widely used to provide complete nutritional support but 30-40% of TPN recipients are considered to in a malnourished state due to inappropriate TPN prescriptions. Computer-assisted TPN prescription systems are thought to be useful to clinical professionals in solving this problem because they can perform complicated calculations that make it easy to draw up correct TPN prescriptions. So, we made a prototype system for aiding the preparation of TPN prescriptions based on Microsoft^[ !R] EXCEL and it was tested by physicians, pharmacists, dietitians and nurses engaged in TPN therapy at Tokushima University Hospital. We also had them fill out a questionnaire on the system in which they rated it for ease of operation and usefulness according to a scoring system in which 5 indicated full marks. Our Computer-Assisted TPN Prescription System was improved on the basis of the questionnaire results and is now being effectively used by the nutrition support team (NST) in Tokushima University Hospital. (キーワード) computer-assisted TPN prescription system / calculation software / TPN (total parenteral nutrition) / fluid therapy / questionnaire (出版サイトへのリンク) ● Publication site (DOI): 10.5649/jjphcs.31.279 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679753550336 ● Search Scopus @ Elsevier (DOI): 10.5649/jjphcs.31.279 (DOI: 10.5649/jjphcs.31.279, CiNii: 1390282679753550336)
51.	Kenji Ikuta, Kazu Takemura, Kenichi Sasaki, Masaru Kihara, Masuhiro Nishimura, Nobuhiko Ueda, Shinsaku Naito, Eibai Lee, Eiji Shimizu and Aiko Yamauchi : Expression of multidrug resistance proteins and accumulation of cisplatin in human non-small cell lung cancer cells, Biological & Pharmaceutical Bulletin, Vol.28, No.4, 707-712, 2005. (要約) In order to understand and overcome multidrug resistance (MDR) of human non-small cell lung cancer (NSCLC), mRNA and protein expression levels of P-glycoprotein (MDR1), multidrug resistance-associated protein 1 (MRP1), and lung resistance-related protein (LRP) were investigated and compared with the chemosensitivity and the intracellular/intranuclear cisplatin accumulation of three NSCLC cell lines (Ma-10, Ma-31, and Ma-46). Ma-31 was more resistant than Ma-10 and Ma-46 to cisplatin, carboplatin, etoposide, and paclitaxel. The mRNA level of MDR1 was extremely low, and MDR1 protein was not detected in all cell lines. MRP1 mRNA expression was highest in Ma-31 and lowest in Ma-10, but there was no notable difference between the MRP1 protein expression in three cell lines. LRP mRNA/protein was equally expressed in Ma-10 and Ma-31, but was nominal in Ma-46. The intracellular/intranuclear cisplatin accumulation of the cells was determined to be Ma-31>Ma-46>Ma-10. Thus, MDR1, MRP1, and LRP mRNA and protein expression levels were not correlated with the chemosensitivity or the intracellular/intranuclear cisplatin accumulation of each cell line. The present results indicate that MDR proteins (MDR1, MRP1, and LRP) may not play an important role in the chemoresistance and drug efflux of NSCLC cells. (キーワード) Antineoplastic Agents / Carcinoma, Non-Small-Cell Lung / Cell Line, Tumor / Cisplatin / Drug Resistance, Neoplasm / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Humans (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.28.707 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15802814 ● Search Scopus @ Elsevier (PMID): 15802814 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.28.707 (DOI: 10.1248/bpb.28.707, PubMed: 15802814)
52.	Masuhiro Nishimura, Mari Yamaguchi, Aiko Yamauchi, Nobuhiko Ueda and Sinsaku Naito : Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up-and- down -regulation induced by overdose of fat-free total parenteral nutrition in infant rats, Drug Metabolism and Pharmacokinetics, Vol.20, No.1, 46-54, 2005. (要約) Total parenteral nutrition (TPN) is associated with cholestasis and hepatic steatosis in human infants. The present study focused on the changes in hepatic xenobiotic transporters associated with overdose of fat-free or fat-containing TPN in infant rats. Three-week-old male Sprague-Dawley rats were divided into three groups: group 1 received an oral diet, group 2 received TPN without fat, and group 3 received TPN with 20% of its calories from fat (soybean oil emulsion). After TPN administration for 4 days, both serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, which are indicators of hepatic dysfunction, in group 2 were significantly higher (p<0.001) than those in the other groups, whereas there were no differences between groups 1 and 3 in either serum AST or ALT levels. The serum bilirubin concentration in group 2 was also markedly higher than that in the other groups. Mdr2, Bsep, Mrp2, Mrp6, Oct1, and Oat2 mRNA levels were decreased in group 2 (fat-free TPN) compared with those in group 1 (oral diet), whereas Mdr1b, Mrp1, and Mrp5 mRNA levels were increased. Specifically, the level of Mdr1b mRNA in group 2 was 16 times higher (p<0.001) than that in group 1. On the other hand, the changes in these mRNA expression levels in group 3 (fat-containing TPN) were smaller than those in group 2, and specifically, the expression levels of Mdr1b, Mrp1, Mrp5, Mrp6, and Oat2 mRNA in group 3 were not significantly different from those in group 1. The results of the present study indicate that including fat in the TPN regimen is very important in preventing the mRNA up- and down-regulation of xenobiotic transporters, which is considered to be the main factor responsible for the abnormal hepatic changes such as cholestasis associated with the excessive administration of fat-free TPN. (キーワード) ATP-Binding Cassette Transporters / Animals / Base Sequence / Carrier Proteins / DNA Primers / Drug Resistance, Multiple / Emulsions / Gene Expression Regulation / Liver / 男性 (male) / Parenteral Nutrition, Total / Plant Oils / RNA, Messenger / Rats / Rats, Sprague-Dawley / Soybeans / Xenobiotics (出版サイトへのリンク) ● Publication site (DOI): 10.2133/dmpk.20.46 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15770074 ● Summary page in Scopus @ Elsevier: 2-s2.0-24144457781 (DOI: 10.2133/dmpk.20.46, PubMed: 15770074, Elsevier: Scopus)
53.	Kenji Ikuta, Kazu Takemura, Masaru Kihara, Masuhiro Nishimura, Nobuhiko Ueda, Shinsaku Naito, Eibai Lee, Eiji Shimizu and Aiko Yamauchi : Overexpression of constitutive signal transducer and activator of transcription 3 mRNA in cisplatin-resistant human non-small cell lung cancer cells., Oncology Reports, Vol.13, No.2, 217-222, 2005. (要約) Non-small cell lung cancer (NSCLC) often shows intrinsic multidrug resistance, which is one of the most serious problems in cisplatin-based adjuvant chemotherapy. Recently, the constitutive activation of signal transducer and activator of transcription (STAT) factors has been found in a variety of human cancers. In the present study, the mRNA expression of STATs in various human NSCLC cell lines was investigated by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) to determine whether STATs can be implicated in cisplatin resistance and apoptosis inducibility. Cisplatin triggered apoptosis in Ma-46 based on biochemical and morphological findings, but not in Ma-31. The mRNA expression of STAT3 was highest in cisplatin-resistant Ma-31 and lowest in cisplatin-sensitive Ma-46. A 6-hour exposure of cancer cells to cisplatin failed to stimulate STAT3 mRNA expression. Therefore, an increased transcriptional level of constitutive STAT3 may be related to the suppressive regulation of the apoptotic pathway in intrinsically chemo-resistant NSCLC cells. (キーワード) Antineoplastic Agents / アポトーシス (apoptosis) / Carcinoma, Non-Small-Cell Lung / Cisplatin / DNA Fragmentation / DNA-Binding Proteins / Drug Resistance, Neoplasm / Gene Expression Regulation, Neoplastic / Humans / Lung Neoplasms / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / STAT3 Transcription Factor / Time Factors / Trans-Activators / Tumor Cells, Cultured (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15643501 ● Search Scopus @ Elsevier (PMID): 15643501 (PubMed: 15643501)
54.	Mari Yamaguchi, Aiko Yamauchi, Masuhiro Nishimura, Nobuhiko Ueda and Sinsaku Naito : Soybean oil fat emulsion prevents cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats., Biological & Pharmaceutical Bulletin, Vol.28, No.1, 143-147, 2005. (要約) Changes in the mRNA expression of hepatic cytochrome P450 (CYP) isoenzymes associated with overdose of fat-free or fat-containing total parenteral nutrition (TPN) were investigated in infant rats. Three-week-old male Sprague-Dawley rats were divided into three groups: group 1 received an oral diet, group 2 received TPN without fat, and group 3 received TPN with 20% of calories from fat (soybean oil emulsion). After TPN administration for 4 d, serum aspartate aminotransferase (AST) levels in group 2 were significantly increased (p<0.01) compared with the other groups. The mRNA expression of hepatic CYP isoenzymes in group 2 decreased to 0.76 to 31% of that in group 1 (p<0.01), but that in group 3 was maintained at 32 to 84% of that in group 1. These results indicate the importance of including fat in TPN regimens to prevent not only hepatic dysfunction but also mRNA down-regulation of liver CYP isoenzymes. (キーワード) Animals / Animals, Newborn / Cytochrome P-450 Enzyme System / Diet, Fat-Restricted / Down-Regulation / Emulsions / Isoenzymes / 男性 (male) / Overdose / Parenteral Nutrition / RNA, Messenger / Rats / Rats, Sprague-Dawley / Soybean Oil (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.28.143 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15635179 ● Summary page in Scopus @ Elsevier: 2-s2.0-18444380233 (DOI: 10.1248/bpb.28.143, PubMed: 15635179, Elsevier: Scopus)
55.	Kentaro Kogure, Aiko Yamauchi, Akira Tokumura, Kyoko Kondou, Naonobu Tanaka, Yoshihisa Takaishi and Kenji Fukuzawa : Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan, Phytomedicine, Vol.11, No.7-8, 645-651, 2004. (要約) We examined the effects of 48 compounds isolated from Ferula pallida, F. penninervis, Inula macrophylla, Prangos pabularia, P. tschimganica and Rheum maximowiczii collected in Uzbekistan on ADP/Fe2+-induced lipid peroxidation of egg yolk phosphatidylcholine liposomes. Of those compounds, 23 inhibited ADP/Fe2+-induced lipid peroxidation and nine showed especially strong inhibition of lipid peroxidation. Most compounds that inhibited peroxidation scavenged the 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radical, indicating that the inhibition was due to radical scavenging. However, some compounds did not scavenge DPPH but inhibited lipid peroxidation significantly, suggesting that their inhibitory effect was not due to radical scavenging but to some other mechanism, such as prevention of Fe2+ function. Thus, we found various new antioxidants, some of which had a unique mechanism of action, in Ferula, Inula, Prangos and Rheum plants collected in Uzbekistan as seeds used in medicine. (キーワード) Antioxidants / Natural products / Ferula / Inula / Prangos / Rheum (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.phymed.2003.09.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15636179 ● Search Scopus @ Elsevier (PMID): 15636179 ● Search Scopus @ Elsevier (DOI): 10.1016/j.phymed.2003.09.004 (DOI: 10.1016/j.phymed.2003.09.004, PubMed: 15636179)
56.	Moe Kyaw, Masanori Yoshizumi, Koichiro Tsuchiya, Yuki Izawa, Yasuhisa Kanematsu, Yoshiko Fujita, Nermin Ali, Keisuke Ishizawa, Aiko Yamauchi and Toshiaki Tamaki : Antioxidant effects of stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on angiotensin II-stimulated MAP kinase activation and vascular smooth muscle cell proliferation, Journal of Pharmacological Sciences, Vol.95, No.4, 483-486, 2004. (要約) We examined the effects of the stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on cellular glutathione (GSH) concentration and whether NAC-regulated cellular GSH levels are directly associated with angiotensin II (Ang II)-induced intracellular signaling events in vascular smooth muscle cells (VSMC). Both L-NAC and D-NAC similarly increased intracellular GSH concentration. We found that L-NAC and D-NAC both inhibited Ang II-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and [(3)H]-thymidine incorporation in VSMC. Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC. (キーワード) Acetylcysteine / Angiotensin II / Animals / Antioxidants / Aorta, Thoracic / Cell Proliferation / Enzyme Activation / Glutathione / JNK Mitogen-Activated Protein Kinases / Male / Mitogen-Activated Protein Kinases / Muscle, Smooth, Vascular / Myocytes, Smooth Muscle / Rats / Rats, Sprague-Dawley / Signal Transduction / Stereoisomerism / Thymidine / p38 Mitogen-Activated Protein Kinases (出版サイトへのリンク) ● Publication site (DOI): 10.1254/jphs.SC0040061 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15297771 ● Search Scopus @ Elsevier (PMID): 15297771 ● Search Scopus @ Elsevier (DOI): 10.1254/jphs.SC0040061 (DOI: 10.1254/jphs.SC0040061, PubMed: 15297771)
57.	山内あい子, 中田栄子, 佐々木幹夫, 後藤尋規, 坂本久美子, 中馬寛 : 医薬品安全性情報コミュニティの構築にむけて, 薬事, Vol.46, No.9, 1675-1681, 2004年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1524232505519399552 (CiNii: 1524232505519399552)
58.	Riyo Enomoto, Hiroyuki Tatsuoka, Tomoe Komai, Chiyoko Sugahara, Kazu Takemura, Aiko Yamauchi, Masuhiro Nishimura, Shinsaku Naito, Toshio Matsuda and Eibai Lee : Involvement of histone phosphorylation in apoptosis of human astrocytes after exposure to saline solution, Neurochemistry International, Vol.44, No.6, 459-467, 2004. (要約) We have previously found using inhibitors of protein phosphatase that phosphorylation of histones may be involved in thymocyte apoptosis. In this study, we examined whether histone modification occurs in astrocyte apoptosis induced by a pathological condition in the absence of drug. Incubation of cultured human astrocytes with growth medium for 24 h after exposure to saline solution for 30 min induced an increase in terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells and nuclear condensation, biochemical and morphological hallmarks of apoptotic cell death. Acetic acid-urea-Triton X-100 (AUT) gel electrophoresis of the nuclear histone fraction and N-terminal peptide analysis showed that the treatment with saline solution caused rapid changes in phosphorylation of H2A subfamilies, but not in histone acetylation. The phosphorylation of the two subtypes increased markedly, whereas the phosphorylation of one subtype decreased. In contrast, exposure to ACF-95, an artificial cerebrospinal fluid (CSF), was associated with little induction of apoptotic cell death and induced less changes in histone phosphorylation. These results support the previous idea that chemical modification of histones is involved in the DNA fragmentation in astrocytes undergoing apoptosis. (キーワード) Amino Acid Sequence / アポトーシス (apoptosis) / Astrocytes / Histones / Humans / In Situ Nick-End Labeling / Molecular Sequence Data / リン酸化 (phosphorylation) / Sodium Chloride (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S0197-0186(03)00175-X (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14687611 ● Summary page in Scopus @ Elsevier: 2-s2.0-10744221212 (DOI: 10.1016/S0197-0186(03)00175-X, PubMed: 14687611, Elsevier: Scopus)
59.	Aiko Yamauchi, Eiko Nakata Doolin, Kumiko Sakamoto, Hiroki Goto, Mikio Sasaki and Hiroshi Chuman : Construction of a drug safety information community in Japan, Drug Metabolism Reviews, Vol.36, No.suppl1, 233, 2004.
60.	Liu Xiangli, Hideji TANAKA, Aiko Yamauchi, Bernard Testa and Hiroshi Chuman : Lipophilicity measurement by reversed-phase high-performance liquid chromatography (RP-HPLC): A comparison of two stationary phases based on retention mechanisms, Helvetica Chimica Acta, Vol.87, No.11, 2866-2876, 2004. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/hlca.200490258 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-11144253473 (DOI: 10.1002/hlca.200490258, Elsevier: Scopus)
61.	山内あい子, 中田栄子, 中馬寛 : 双方向·成長型薬物催奇形性情報コミュニテイの構築, Journal of Computer Chemistry, Japan, Vol.2, No.3, 71-78, 2003年. (要約) 薬物が原因で起こる胎児奇形は，頻度は低いが薬物治療において決して起こしてはならない副作用である．しかし，わが国には，妊娠に気づかずクスリを服用したとして過度の不安を抱いている妊婦に対する適切な情報提供システムがない．また，開発の中断された医薬品候補化合物の生殖・発生毒性情報は，公開され有効に利用されることなく企業の研究室に眠っているのが実状である．そこで，我々は，インターネット上に情報提供・収集システムを構築し，妊婦(市民)・医療関係者・研究者に情報コミュニティの場を提供することを目指している．先導研究として，Web上で医薬品催奇形性情報と化学構造式に関する条件検索が可能で，さらにクライアント側からも臨床症例登録のできる双方向・成長型の試用データベースを作成した．薬物催奇形性情報コミュニティの実現は，妊婦に対する根拠に基づいた薬物治療の実践と，情報化学的解析手法を用いた効率的な医薬品研究開発に資するものと期待される． (キーワード) 薬物催奇形性情報コミュニティ / 双方向・成長型データベースシステム / 妊娠とくすり / 医薬品研究開発 / 情報化学 / Clinical QSAR (出版サイトへのリンク) ● Publication site (DOI): 10.2477/jccj.2.71 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680156232192 ● Search Scopus @ Elsevier (DOI): 10.2477/jccj.2.71 (DOI: 10.2477/jccj.2.71, CiNii: 1390282680156232192)
62.	Aiko Yamauchi : Project of the database construction for teratogenic agents-construction of the growing information -community for teratogenic agents, The Journal of Toxicological Sciences, Vol.27, No.4, 280, 2002. (キーワード) W2-6 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570854176860841216 (CiNii: 1570854176860841216)
63.	Riyo Enomoto, Hiroyuki Tatsuoka, Yukari Yoshida, Tomoe Komai, Kaori Node, Rieko Nogami, Aiko Yamauchi and Eibai Lee : Thymocyte apoptosis induced by phosphorylation of histones is associated with the change in chromatin structure to allow easy accessibility of DNase, IUBMB life, Vol.54, No.3, 123-127, 2002. (要約) The inhibitors of protein phosphatase such as calyculin A and okadaic acid induce the apoptotic cell death in rat thymocytes. To clarify the molecular mechanism of these inhibitor-induced apoptosis, the effect of calyculin A on DNA fragmentation in the isolated nuclei were studied. A significant increase in DNA fragmentation was observed in the nuclei prepared from the cells treated with calyculin A that caused histone hyperphosphorylation. No changes of the activities of caspase-8 and -3 were observed in the extract from the cells treated with calyculin A. The circular dichroism analysis of soluble chromatin from calyculin A-treated thymocyte nuclei indicated that phosphorylation of histones decreased its alpha-helical content. Thus, the change in the chromatin structure may be due to the chemical modification of histones. Moreover, the structural change in chromatin preceded DNA fragmentation in the nuclei. Therefore, these results suggest that the change of chromatin structure allow easy accessibility of nuclear DNase to chromosomal DNA. (キーワード) Animals / アポトーシス (apoptosis) / Caspases / Chromatin / Circular Dichroism / Cysteine Proteinase Inhibitors / Deoxyribonucleases / Histones / Oxazoles / リン酸化 (phosphorylation) / Rats / Thymus Gland (出版サイトへのリンク) ● Publication site (DOI): 10.1080/15216540214536 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12489639 ● Search Scopus @ Elsevier (PMID): 12489639 ● Search Scopus @ Elsevier (DOI): 10.1080/15216540214536 (DOI: 10.1080/15216540214536, PubMed: 12489639)
64.	Yasumasa Iwai, Kumiko Kita, Yoko Matsushita, Aiko Yamauchi and Masaru Kihara : New entry of coupling reaction of phenacylamine derivatives with silylstannane, Chemical & Pharmaceutical Bulletin, Vol.50, No.3, 441-443, 2002. (要約) The new coupling reaction of phenacylamines with silylstannane and lithium diisopropylamide (LDA) is reported. The treatment of a phenacylamine iodide 1 with (trimethylsilyl)tributylstannane (Me_3SiSnBu_3) and cesium fluoride (CsF) gave a dimerization product 2 having no iodine atom. Reaction of 1 with LDA afforded a dimerization product 3 with an iodine atom. The products 2 and 3 were separated to the meso and racemic isomers, respectively. (キーワード) coupling reaction / enolate / silylstannane / phenacylamine (出版サイトへのリンク) ● Publication site (DOI): 10.1248/cpb.50.441 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679138855808 ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.50.441 (DOI: 10.1248/cpb.50.441, CiNii: 1390282679138855808)
65.	Aiko Yamauchi, Nobuhiko Ueda, Sayuri Hanafusa, Eri Yamashita, Masaru Kihara and Shinsaku Naito : Tissue Distribution of and Species Differences in Deacetylation of N-Acetyl-L-Cysteine and Immunohistochemical Localisation of Acylase I in the Primate Kidney, The Journal of Pharmacy and Pharmacology, Vol.54, No.2, 205-212, 2002. (要約) Species differences in the biotransformation of N-acetyl-L-cysteine (NAC) have been investigated to evaluate the usefulness of NAC as a constituent in parenteral nutrition solutions in place of cysteine. The activity of NAC-deacetylating enzyme (acylase) was measured in various tissues of different species (rat, rabbit, dog, monkey, and man). Acylase activity was highest in the kidney in all species studied. Enzyme activity in the liver was 10 %-22 % of that in the kidney in the rat, rabbit, monkey, and man, but almost no hepatic activity was seen in the dog. NAC-deacetylating activity was very low in other organs. The tissue distribution of acylase I was determined by Western blotting and an immunohistochemical method employing specific antibody against porcine acylase I (EC 3.5.1.14). The immunoblotting study showed a 46-kDa protein band corresponding to porcine acylase I in the kidney of all species. In liver cytosol, 46 kDa and/or 29 kDa bands were observed in the rat, rabbit, monkey, and man, but not in the dog. In the immunohistochemical study, positive staining with anti-acylase I antibody was observed clearly in the renal proximal tubules in the monkey and man. These results suggested that the kidney and liver were the main organs responsible for the biotransformation of NAC to cysteine in mammals other than the dog. (キーワード) Acetylation / Acetylcysteine / Amidohydrolases / Animals / Biotransformation / Blotting, Western / Chromatography, High Pressure Liquid / Dogs / Electrophoresis, Polyacrylamide Gel / Humans / 免疫組織化学 (immunohistochemistry) / Kidney / Liver / Macaca fascicularis / Organ Specificity / Parenteral Nutrition / Rabbits / Rats / Rats, Wistar / Species Specificity / Tissue Distribution (出版サイトへのリンク) ● Publication site (DOI): 10.1211/0022357021778394 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11848284 ● Search Scopus @ Elsevier (PMID): 11848284 ● Search Scopus @ Elsevier (DOI): 10.1211/0022357021778394 (DOI: 10.1211/0022357021778394, PubMed: 11848284)
66.	Nobuhiko Ueda, Aiko Yamauchi, Masaru Kihara and Shinsaku Naito : Biotransformation of N-acetyl-L-cysteine:Tissue distribution and species difference of its deacetylation, Drug Metabolism Reviews, Vol.32, No.suppl2, 271, 2000.
67.	Eibai Lee, Akira Nakatsuma, Rikako Hiraoka, Eriko Ishikawa, Aiko Yamauchi and Riyo Enomoto : Involvement of histone phosphorylation in thymocyte apoptosis by protein phosphatase inhibitors, IUBMB life, Vol.48, No.1, 79-83, 1999.
68.	Nobuya Kusunoki, Kohji Takara, Yusuke Tanigawara, Aiko Yamauchi, Kazumitsu Ueda, Fusao Komada, Yonson Ku, Yoshikazu Kuroda, Yohichi Saitoh and Katsuhiko Okumura : Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human p-glycoprotein, Japanese Journal of Cancer Research, Vol.89, No.11, 1220-1228, 1998. (要約) The inhibitory effects of SDZ PSC 833 (PSC833), a non-immunosuppressive cyclosporin derivative, on the P-glycoprotein (P-gp)-mediated transport of doxorubicin and vinblastine were compared with those of cyclosporin A (Cs-A). The transcellular transport of the anticancer drugs and PSC833 across a monolayer of LLC-GA5-COL150 cells, which overexpress human P-gp, was measured. Both PSC833 and Cs-A inhibited P-gp-mediated transport of doxorubicin and vinblastine in a concentration-dependent manner and increased the intracellular accumulation of doxorubicin and vinblastine in LLC-GA5-COL150 cells. The values of the 50%-inhibitory concentration (IC50) of PSC833 and Cs-A for doxorubicin transport were 0.29 and 3.66 microM, respectively, and those for vinblastine transport were 1.06 and 5.10 microM, respectively. The IC50 of PSC833 for doxorubicin transport was about 4-fold less than that for vinblastine transport, suggesting that the combination of PSC833 and doxorubicin might be effective. PSC833 itself was not transported by P-gp and had higher lipophilicity than Cs-A. These results indicated that the inhibitory effect of PSC833 on P-gp-mediated transport was 5- to 10-fold more potent than that of Cs-A, and this higher inhibitory effect of PSC833 may be related to the absence of PSC833 transport by P-gp and to the higher lipophilicity of PSC833. (キーワード) ATP Binding Cassette Transporter, Subfamily B, Member 1 / Animals / Antineoplastic Agents / Biological Transport / Cell Line / Cyclosporine / Cyclosporins / Doxorubicin / Humans / Immunosuppressive Agents / Vinblastine (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1349-7006.1998.tb00518.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9914792 ● Summary page in Scopus @ Elsevier: 2-s2.0-20244370494 (DOI: 10.1111/j.1349-7006.1998.tb00518.x, PubMed: 9914792, Elsevier: Scopus)
69.	Masaru Kihara, Motoki Ikeuchi, Aiko Yamauchi, Mamoru Nukatsuka, Hiroshi Matsumoto and Toshiyuki Toko : Synthesis and biological evaluation of 7-hydroxy-3,4-diphenyl-1,2-dihydroquinolines as new 4-hydroxytamoxifen analogues, Chemical & Pharmaceutical Bulletin, Vol.45, No.5, 939-943, 1997. (出版サイトへのリンク) ● Publication site (DOI): 10.1248/cpb.45.939 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1248/cpb.45.939 (DOI: 10.1248/cpb.45.939)
70.	Eibai Lee, Taku Furukubo, Takashi Miyabe, Aiko Yamauchi and Kimio Kariya : Involvement of histone hyperacetylation in triggering DNA fragmentation of rat thymocytes undergoing apoptosis, FEBS Letters, Vol.395, No.2, 183-187, 1996. (要約) The treatment of rat thymocytes with trichostatin A and sodium butyrate, which are inhibitors of histone deacetylase, resulted in an increase in DNA fragmentation in a concentration-dependent manner. A significant increase in DNA fragmentation induced by these compounds was observed after a lag time of 2 h. Analysis of the fragmented DNA revealed the production of approximately 50 kb DNA fragments and DNA ladders, the biochemical hallmarks of apoptotic cell death. Judging from a laser scanning microscopic analysis, the inhibitors of histone deacetylase induced nuclear condensation, the morphological feature of apoptosis. Biochemical and morphological analyses demonstrated that trichostatin A and sodium butyrate induced thymocyte apoptosis. Furthermore, hyperacetylation of nuclear histones was observed in thymocytes treated with the inhibitors of histone deacetylase. These effects of sodium butyrate and trichostatin A were seen 0.5 and 1 h, respectively, after incubation of the cells. These results thus indicate that hyperacetylation of nucleosomal histones precedes DNA fragmentation in thymocytes undergoing apoptosis induced by trichostatin A and sodium butyrate. (キーワード) Acetylation / Acetyltransferases / Animals / アポトーシス (apoptosis) / Butyrates / Butyric Acid / Cells, Cultured / DNA (DNA) / Enzyme Inhibitors / Histone Acetyltransferases / Histones / Hydroxamic Acids / Kinetics / Rats / Rats, Sprague-Dawley / Saccharomyces cerevisiae Proteins / Tリンパ球 (T lymphocytes) (出版サイトへのリンク) ● Publication site (DOI): 10.1016/0014-5793(96)01033-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8898091 ● Summary page in Scopus @ Elsevier: 2-s2.0-0030597111 (DOI: 10.1016/0014-5793(96)01033-2, PubMed: 8898091, Elsevier: Scopus)
71.	山崎裕康, 山口孝子, 山内あい子, 垣内靖男 : 食品添加物天然赤色系着色料のウサギ血小板機能に及ぼす影響, 衛生化学, Vol.41, No.5, 375-380, 1995年. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0028857983 (Elsevier: Scopus)
72.	山口孝子, 山崎裕康, 山内あい子, 垣内靖男 : 道路近傍における浮遊粒子状物質中のタイヤレッド磨耗粉じん及びゴム添加剤の分析, 衛生化学, Vol.41, No.2, 155-162, 1995年. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0029017007 (Elsevier: Scopus)
73.	Takako Yamaguchi, Hiroshi Uehara, Hiroko Oka, Tsuyoshi Saitou, Hiroyasu Yamazaki, Aiko Yamauchi and Yasuo Kakiuchi : Mutagenicity and property of airborne particulates in a roadside atmosphere, Japanese Journal of Toxicology and Environmental Health, Vol.40, No.1, 12, 1994. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679473951744 ● Summary page in Scopus @ Elsevier: 2-s2.0-0028206916 (CiNii: 1390282679473951744, Elsevier: Scopus)
74.	Hiroyasu Yamazaki, Megumi Ito, Miho Fujiwara, Takako Yamaguchi, Aiko Yamauchi and Yasuo Kakiuchi : Effect of food additives on rabbit platelet function ( II ), Japanese Journal of Toxicology and Environmental Health, Vol.40, No.1, 41, 1994. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0028345952 (Elsevier: Scopus)
75.	山口孝子, 山崎裕康, 山内あい子, 垣内靖男 : 道路近傍における浮遊粒子状物質の変異原性について, 衛生化学, Vol.40, No.6, 542-549, 1994年.
76.	Hiroyasu Yamazaki, Takako Yamaguchi, Aiko Yamauchi and Yasuo Kakiuchi : Food additives on acceptable daily intake (ADI) level affect the agonist induced platelet activation I. antioxidants and preservatives, Chemosphere, Vol.29, No.6, 1293-1299, 1994.
77.	山崎裕康, 山口孝子, 山内あい子, 垣内靖男 : 食品添加物(赤色系合成着色料)のウサギ血小板機能に及ぼす影響, 衛生化学, Vol.40, No.5, 448-453, 1994年.
78.	Hiroyasu Yamazaki, T Yamaguchi, Aiko Yamauchi and Yasuo Kakiuchi : Effect of food additives on rabbit platelet function, Japanese Journal of Toxicology and Environmental Health, Vol.39, 16, 1993.
79.	山崎裕康, 山口孝子, 山内あい子, 垣内靖男 : 食品添加物(酸化防止剤)のウサギ血小板機能に及ぼす影響, 衛生化学, Vol.39, No.5, 453-458, 1993年. (出版サイトへのリンク) ● Publication site (DOI): 10.1248/jhs1956.39.5_453 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0027131410 (DOI: 10.1248/jhs1956.39.5_453, Elsevier: Scopus)
80.	Aiko Yamauchi, G J Stijintje, J M N Commandeur and N E P Vermeulen : Purification of glutamine transferase K/cysteine conjugate β-lyase from rat renal cytosol based on hydrophobic interaction HPLC and gelpermeation FPLC, Protein Expression and Purification, Vol.4, No.6, 552-562, 1992. (要約) Cysteine conjugate beta-lyase (beta-lyase, EC 4.4.1.13) was purified to homogeneity from rat renal cytosol using a new and highly efficient method, based on C3-hydrophobic interaction (HI) high-performance liquid chromatography (HPLC) in combination with gel permeation fast protein liquid chromatography. The purity of the enzyme was judged from SDS-PAGE and C18-reversed-phase HPLC. The beta-lyase was estimated to be a homodimer consisting of a 47,400-Da subunit with absorption maxima at 280 and 420-430 nm. The specific activity of the purified beta-lyase toward S-(1,2-dichlorovinyl)-L-cysteine (1,2-DCVC) in the presence of alpha-keto-gamma-methiolbutyric acid (KMB) was 6.4 mumol/min/mg protein, which is by far the highest value so far reported. Kinetic analysis of 1,2-DCVC metabolism by the enzyme in the presence of KMB gave Km and Vmax values of 0.33 mM and 8.4 mumol/min/mg protein, respectively. No significant activity of the purified enzyme was detectable with S-2-benzothiazolyl-L-cysteine up to 2 mM. The purified enzyme also had glutamine transaminase K activity (EC 2.6.1.64) as assayed with phenylalanine and KMB as substrates. This specific activity was 16.0 mumol/min/mg. Amino acid analysis of the purified beta-lyase was carried out and was found to be closely similar to the amino acid composition of five other pyridoxal phosphate (PLP)-containing amino acid amino-transferases. This suggests that glutamine transaminase K/cysteine conjugate beta-lyase is a typical member of the PLP-containing aminotransferase group. (キーワード) Amino Acids / Animals / Carbon-Sulfur Lyases / Chromatography, Gel / Chromatography, High Pressure Liquid / Cytosol / Kidney / Lyases / 男性 (male) / Rats / Rats, Wistar / Sequence Analysis / Transaminases (出版サイトへのリンク) ● Publication site (DOI): 10.1006/prep.1993.1073 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8286953 ● Summary page in Scopus @ Elsevier: 2-s2.0-0027770365 (DOI: 10.1006/prep.1993.1073, PubMed: 8286953, Elsevier: Scopus)
81.	Hiroyasu Yamazaki, Nobuko Take, Kaori Tachibana, Takako Yamaguchi, Aiko Yamauchi and Yasuo Kakiuchi : Effect of environmental pollutants on activation of rabbit platelets, Japanese Journal of Toxicology and Environmental Health, Vol.38, No.1, 18, 1992. (出版サイトへのリンク) ● Publication site (DOI): 10.1248/jhs1956.38.P18 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0026609116 (DOI: 10.1248/jhs1956.38.P18, Elsevier: Scopus)
82.	Hiroyasu Yamazaki, Takako Yamaguchi, Aiko Yamauchi and Yasuo Kakiuchi : Effect of halocarbons and styrene on thrombin and calcium ionophore induced activation of rabbit platelets, Chemosphere, Vol.25, No.5, 665-673, 1992.
83.	山口孝子, 山内あい子, 山崎裕康, 垣内靖男 : タイヤ抽出物の変異原性に対するゴム添加剤の共存効果, 衛生化学, Vol.38, No.6, 506-510, 1992年.
84.	Hiroyasu Yamazaki, Masaki Inoi, Takako Yamaguchi, Aiko Yamauchi, Yasuo Kakiuchi and Hsin-Hsiung Tai : Rubber additive inhibit the calcium ionophore and thrombin induced activation of rabbit platelets, Chemosphere, Vol.22, No.9-10, 859-867, 1992.
85.	Hiroyasu Yamazaki, Masaki Inoi, Takako Yamaguchi, Aiko Yamauchi and Yasuo Kakiuchi : Effect of rubber additives on activation of rabbit platelets, Japanese Journal of Toxicology and Environmental Health, Vol.37, No.1, 22, 1991. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-17944396907 (Elsevier: Scopus)
86.	Aiko Yamauchi, Hiroyasu Yamazaki and Yasuo Kakiuchi : Changes in the composition of glutathione transferase subunits in rat liver after oral administration of benzo(a)pyrene, Toxicological and Environmental Chemistry, Vol.33, No.1-2, 111-119, 1991.
87.	山口孝子, 山内あい子, 山崎裕康, 垣内靖男 : タイヤ中に使用されているゴム添加剤の変異原性について, 衛生化学, Vol.37, No.1, 6-13, 1991年.
88.	Takako Yamaguchi, Aki Asada, Aiko Yamauchi, Hiroyasu Yamazaki and Yasuo Kakiuchi : Mutagenicity of tire extracts, Japanese Journal of Toxicology and Environmental Health, Vol.36, No.1, 16, 1990. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204497956224 ● Summary page in Scopus @ Elsevier: 2-s2.0-0025344560 (CiNii: 1390001204497956224, Elsevier: Scopus)
89.	山崎裕康, 山内あい子, 細野恭平, 垣内靖男, 藤井正美 : 水溶性ビタミン安定性に及ぼす赤色系着色料の影響, 生活衛生, Vol.34, No.1, 36-40, 1990年.
90.	Hiroyasu Yamazaki, Eiko Imamura, Sumi Kamei, Aiko Yamauchi, Yasuo kakiuchi and Hsin-Hsiung Tai : Polycyclic aromatic hydrocarbons affect the calcium ionophore induced activation of rabbit platelet, Chemosphere, Vol.21, No.1-2, 21-28, 1990.
91.	Aiko Yamauchi, Takako Ohtsuka, Hiroyasu Yamazaki and Yasuo Kakiuchi : Regulation of microsomal glutathione transferase activity in benzo(a)pyrene administered rat liver, Journal of Pharmacobio-Dynamics, Vol.12, No.3, s-66, 1989.
92.	Aiko Yamauchi, Noritake Matsumoto, Hiroyuki Nakagawa, Takako Ohtsuka, Hiroyasu Yamazaki and Yasuo Kakiuchi : High-performance liquid chromato-graphic analysis of polycyclic aromatic hydrocarbons extracted from river waters, Japanese Journal of Toxicology and Environmental Health, Vol.35, No.1, 3, 1989.
93.	山内あい子, 松本典丈, 中川博之, 大塚孝子, 山崎裕康, 垣内靖男 : ブルーコットン吸着法による河川水中の多環芳香族炭化水素の分析, 衛生化学, Vol.35, No.4, 283-290, 1989年.
94.	垣内靖男, 山内あい子, 濱志保子, 山崎裕康 : 酸敗油脂水抽出-TBA比色法における反応生成物質の分析, 衛生化学, Vol.35, No.4, 291-296, 1989年. (出版サイトへのリンク) ● Publication site (DOI): 10.1248/jhs1956.35.291 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1248/jhs1956.35.291 (DOI: 10.1248/jhs1956.35.291)
95.	Kimio Kariya, M Sasaki and Aiko Yamauchi : Relationship between central kinin system and hypertensive response in spontaneously hypertensive rat, Jpn.Heart J., Vol.29, 555, 1988.
96.	Kimio Kariya, Aiko Yamauchi and Eibai Lee : Sex-related difference of kinin level in rat pituitary gland, Life Sciences, Vol.40, No.4, 407-412, 1987. (要約) The kinin level in the pituitary glands was compared in adult male and female rats. A sex-related difference in the bradykinin (BK)-like immunoreactivity was found in the posterior lobe. The posterior pituitaries of female rats contained a higher concentration of the immunoreactive kinin than those of males. Ovariectomy of female rats resulted in the disappearance of a sex difference in the posterior kinin level and about a 3-fold increase in the anterior one. Orchidectomy of adult male rats failed to alter the kinin levels in both lobes. Moreover, the constitution of pituitary kinins was determined using HPLC. The pituitary kinins consisted of BK, Lys-BK (L-BK) and Met-Lys-BK (ML-BK) in different proportions in both lobes of male and female rats. The gonadectomy altered the proportions of these kinins. These results suggest that the pituitary kinin system may be regulated by circulating gonadal steroid hormones. (キーワード) Animals / Bradykinin / 女性 (female) / 男性 (male) / Orchiectomy / Ovariectomy / Pituitary Gland, Anterior / Pituitary Gland, Posterior / Rats / Rats, Inbred Strains / Sex Characteristics (出版サイトへのリンク) ● Publication site (DOI): 10.1016/0024-3205(87)90143-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3807641 ● Summary page in Scopus @ Elsevier: 2-s2.0-0023665466 (DOI: 10.1016/0024-3205(87)90143-3, PubMed: 3807641, Elsevier: Scopus)
97.	Kimio Kariya, Aiko Yamauchi, M Sasaki and S Ohnishi : Reactivity to bradykinin of the isolated ileum and duodenum from spontaneously hypertensive rats, Jpn.Heart J., Vol.28, No.4, 633, 1987. (出版サイトへのリンク) ● Publication site (DOI): 10.1536/ihj.28.633 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.28.633 (DOI: 10.1536/ihj.28.633)
98.	Kimio Kariya and Aiko Yamauchi : Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein, The Japanese Journal of Pharmacology, Vol.43, No.2, 129-132, 1987. (出版サイトへのリンク) ● Publication site (DOI): 10.1254/jjp.43.129 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1254/jjp.43.129 (DOI: 10.1254/jjp.43.129)
99.	Kimio Kariya, Aiko Yamauchi and Eibai Lee : A Study on kinin system in rat pituitary gland, Neurochemical Research, Vol.11, No.12, 1762, 1986.
100.	山内あい子, 瀧敏孝, 仮家公夫 : ラット脳Adenosine受容体に及ぼすTaurineの影響, 含硫アミノ酸, Vol.9, 29-34, 1986年.
101.	Aiko Yamauchi, Atsumu Nakayama and Kimio Kariya : Determination of kinin in the rat brain by a sensitive radioimmunoassay, Journal of Pharmacobio-Dynamics, Vol.8, No.8, 607-613, 1985.
102.	Kimio Kariya, Aiko Yamauchi and T Sasaki : Regional distribution and characterization of kinin in the CNS of the rat, Journal of Neurochemistry, Vol.44, No.6, 1892-1897, 1985. (要約) The distribution of kinin in the CNS of the rat, which was extracted with n-butanol from an acidified homogenate, was determined using a bradykinin (BK) radioimmunoassay system. The immunoreactive kinin was widely distributed throughout the brain. The highest content was found in the pituitary gland (4,135 fmol BK Eq/g), followed by the medulla oblongata (912 fmol/g), cerebellum (549 fmol/g), and cortex (512 fmol/g). The kinin in the posterior pituitary was concentrated 4.5 times as much as in the anterior lobe. Serial dilution of brain extracts produced binding curves parallel to the standard radioimmunoassay curve. The purified brain kinin comigrated with authentic BK during CM-cellulose chromatography and Sephadex LH-20 gel chromatography. Its molecular weight was estimated to be 1,127 +/- 45 by gel filtration, which coincides well with that of BK. Chymotrypsin degraded the extracted kinin and authentic BK, but trypsin did not. These data demonstrate that a peptide indistinguishable from BK exists in the rat brain. Furthermore, pituitary kinin was separated into BK (87%), Lys-BK (10%), and Met-Lys-BK (3%), using reverse phase HPLC. (キーワード) Animals / Bradykinin / Brain Chemistry / Chromatography, High Pressure Liquid / Kinins / 男性 (male) / 下垂体 (pituitary gland) / Rabbits / Rats / Rats, Inbred Strains (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1471-4159.1985.tb07185.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3989568 ● Summary page in Scopus @ Elsevier: 2-s2.0-0021887659 (DOI: 10.1111/j.1471-4159.1985.tb07185.x, PubMed: 3989568, Elsevier: Scopus)
103.	仮家公夫, 山内あい子, 李英培 : ラット下垂体キニン系に関する研究, 神経化学, Vol.24, No.1, 289-304, 1985年.
104.	Kimio Kariya, Aiko Yamauchi, S Hattori, Yuko Tsuda and Yoshio Okada : The disappearance rate of intraventricular bradykinin, Biochemical and Biophysical Research Communications, Vol.107, No.4, 1461-1466, 1985.
105.	Kimio Kariya, Aiko Yamauchi and Y Chatani : Relationship between central actions of bradykinin and prostaglandins in the conscious rat, Neuropharmacology, Vol.21, No.3, 267-272, 1982. (要約) Intraventricular injection of bradykinin produced a dose-dependent increase in the mean arterial blood pressure of conscious rats. With 5 nmol of bradykinin, a dual pressor response was observed, which was associated with a biphasic behavioral change. With repeated hourly injections of bradykinin, tachyphylaxis developed to the pressor and central nervous system (CNS) stimulating effect. Indomethacin, given intraventricularly, reduced the hypertension and the behavioral excitation caused by bradykinin in a dose-dependent manner. When prostaglandin E2 was injected into the cerebral ventricles, it induced hypertension and behavioral sedation similar to the secondary response to bradykinin. These results suggest that bradykinin has a dual action on the CNS, and this is mediated by prostaglandin-related systems in the brain. (キーワード) Animals / Behavior, Animal / 血圧 (blood pressure) / Bradykinin / 脳 (brain) / 意識 (consciousness) / Indomethacin / Injections, Intraventricular / Male / Prostaglandins / Prostaglandins E / Rats / Rats, Inbred Strains (出版サイトへのリンク) ● Publication site (DOI): 10.1016/0028-3908(82)90197-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7070602 ● Search Scopus @ Elsevier (PMID): 7070602 ● Search Scopus @ Elsevier (DOI): 10.1016/0028-3908(82)90197-6 (DOI: 10.1016/0028-3908(82)90197-6, PubMed: 7070602)
106.	Kimio Kariya and Aiko Yamauchi : Effects of intraventricular injection of bradykinin on the EEG and the blood pressure in conscious rats, Neuropharmacology, Vol.20, No.12, 1221-1224, 1981. (キーワード) Animals / 血圧 (blood pressure) / Bradykinin / 脳 (brain) / Electroencephalography / Injections, Intraventricular / Male / Rats / Rats, Inbred Strains / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1016/0028-3908(81)90068-X (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7322298 ● Search Scopus @ Elsevier (PMID): 7322298 ● Search Scopus @ Elsevier (DOI): 10.1016/0028-3908(81)90068-X (DOI: 10.1016/0028-3908(81)90068-X, PubMed: 7322298)
107.	Kimio Kariya, Hideo Iwaki, Aiko Yamauchi, Midori Okamoto, Yuko Tsuda and Yoshio Okada : Central action of bradykinin (II) Separation of bradykinin degrading enzyme from the rat brain, The Japanese Journal of Pharmacology, Vol.31, No.4, 613-619, 1981.
108.	Aiko Hashimoto and J Kawada : Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats, Endocrinologia Japonica, Vol.26, No.3, 337-344, 1979. (要約) Insulin encapsulated in liposomes of various lipid compositions were prepared. The amount of insulin trapped in these liposomes increased in the order, negatively charged liposomes less than neutral liposomes less than positively charged liposomes. In positively charged liposomes, the amount of insulin trapped increased with increase in the amount of amphiphile stearylamine. Under the conditions tested, the highest insulin content (about 50%) was obtained with liposomes composed of phosphatidyl choline/cholesterol/stearylamine in a molar ratio of 7/2/2.25. These liposomes were stable on incubation for 3 hr at 37 degrees C in solutions of pepsin, trypsin, and pancreatin, and after these incubations, a considerable amount of insulin was still associated with the liposomes. However, the liposomes released almost all the insulin into the medium on treatment with bile. When the liposomes were administered orally to rats in the 3rd phase of acute alloxan diabetes, reduction of the blood glucose level was observed in 7 of 11 animals, the reduction persisted for several hours and was ranging from 30 to 75%. In alloxan diabetic rats showing hyperglycemia for 3 to 6 months, the liposomes also increased the glucose tolerance in half the animals tested. (キーワード) Administration, Oral / Animals / Blood Glucose / Chronic Disease / Diabetes Mellitus, Experimental / Drug Stability / Glucose Tolerance Test / インスリン (insulin) / リポソーム (liposomes) / 男性 (male) / Rats (出版サイトへのリンク) ● Publication site (DOI): 10.1507/endocrj1954.26.337 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 477621 ● Summary page in Scopus @ Elsevier: 2-s2.0-0018718071 (DOI: 10.1507/endocrj1954.26.337, PubMed: 477621, Elsevier: Scopus)
109.	Y Okada, Y Tsuchiya, M Yagyu, Aiko Hashimoto and K Kariya : Effect of bradykinin fragments and their analogs on central nervous system, Peptide Chemistry, Vol.1978, 79-84, 1979.
110.	K Kariya, H Okamoto, H Iwaki, Aiko Hashimoto, M Yagyu, Y Tsuchiya and Y Okada : Studies of the effects of bradykinin and its fragments on the central nervous system, Advances in Experimental Medicine and Biology, Vol.120, No.b, 487-497, 1979. (キーワード) Amino Acid Sequence / Animals / Bradykinin / 脳 (brain) / Chelating Agents / Kinetics / 男性 (male) / Peptide Fragments / Peptide Hydrolases / Rats / 構造活性相関 (structureactivity relationship) / Sulfhydryl Reagents (出版サイトへのリンク) ● Publication site (DOI): 10.1007/978-1-4757-0926-1_44 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 495330 ● Summary page in Scopus @ Elsevier: 2-s2.0-0018402061 (DOI: 10.1007/978-1-4757-0926-1_44, PubMed: 495330, Elsevier: Scopus)

学術論文(紀要・その他):

1.	Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins, Peptide Science 2013, 205-206, 2014.
2.	Aiko Yamauchi, Kumiko Sakamoto, Eiko Doolin Nakata, Makoto Tani, Mikio Sasaki and Hiroshi Chuman : Constructing a web-based drug-teratogenicity information sharing system, anzen-drug com, Drug Metabolism Reviews, Vol.39, No.suppl1, 316, 2007.
3.	Hideki Uchimi, Kumiko Sakamoto, Makoto Tani, Mikio Sasaki, Aiko Yamauchi and Hiroshi Chuman : Estimating potential risks of pharmaceuticals human fetuses by SimScore in a teratogenicity information sharing system, Drug Metabolism Reviews, Vol.39, No.suppl1, 207, 2007.

学術レター:

1.	吉田麻衣, 坂和園子, 阿部覚, 木原勝, 内藤真策, 山内あい子 : セフェム系抗生物質のラット脳脊髄腔液移行性に関するQSAR解析, SAR NEWS, Vol.14, 12-15, 2008年.
2.	山内あい子, 日比野有紀, 坂本久美子, 中馬寛 : 薬物の胎盤通過性と母乳移行性予測-Clinical QSAR, SAR NEWS, Vol.10, 11-14, 2006年.

総説・解説:

1.	山内あい子 : 新成長戦略で求められる薬剤師の役割拡大, 徳島県病薬会誌, No.94, 1-2, 2014年8月.
2.	山内あい子 : 男女共同参画社会への取り組み㊦, 週刊教育資料, Vol.2014/4/28, No.1295, 28-29, 2014年4月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1521417755153307008 (CiNii: 1521417755153307008)
3.	山内あい子 : 男女共同参画社会への取り組み㊤, 週刊教育資料, Vol.2014/4/14, No.1293, 28-29, 2014年4月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520291855198031616 (CiNii: 1520291855198031616)
4.	山内あい子 : 30歳代を中心とする女性研究者のエンパワーメント, 共同参画, No.64, 5-6, 2014年1月.
5.	山内あい子 : 徳島大学における女性研究者支援の取り組み⑤ -AWA(OUR)サポートシステム事業の成果-, 文部科学教育通信, Vol.326, No.10/28, 16-17, 2013年10月.
6.	山内あい子 : 徳島大学における女性研究者支援の取り組み④ -女性研究者のモチベーション向上のために-, 文部科学教育通信, Vol.325, No.10/14, 16-17, 2013年10月.
7.	山内あい子 : 徳島大学における女性研究者支援の取り組み③ -支援推進の原動力は全学的な意識改革, 文部科学教育通信, Vol.324, No.9/23, 16-17, 2013年9月.
8.	山内あい子 : 徳島大学における女性研究者支援の取り組み② -支援するための環境を整える, 文部科学教育通信, Vol.323, No.9/9, 16-17, 2013年9月.
9.	山内あい子 : 徳島大学における女性研究者支援の取り組み① -女性研究者の現状と必要とされる支援とは?, 文部科学教育通信, Vol.322, No.8/26, 16-17, 2013年8月.
10.	傳田将也, 山本純, 佐藤浩平, 坂本健, 重永章, 佐藤陽一, 吉村好之, 山内あい子, 大髙章 : 新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究, ケミカルバイオロジー, Vol.6, 6-9, 2013年6月.
11.	山内あい子 : 乳汁への薬物移行性の予測, 薬局, Vol.62, No.7, 2766-2771, 2011年6月.
12.	山内あい子 : 妊婦・授乳婦と医薬品情報(6) 医薬品安全性情報コミュニティ・サイト anzen-drug comへようこそ, 県薬だより-情報とくしま-, No.47, 34-38, 2007年3月.
13.	山内あい子 : 催奇形性の情報をネット上で試験公開, 薬事日報, No.10305, 28, 2006年11月.
14.	山内あい子 : 妊婦·授乳婦と医薬品情報(5), 県薬だより-情報とくしま-, No.42, 10-14, 2006年3月.
15.	山内あい子 : 妊婦·授乳婦と医薬品情報(4), 県薬だより-情報とくしま-, No.39, 12-15, 2005年9月.
16.	山内あい子 : 妊婦·授乳婦と医薬品情報(3), 県薬だより-情報とくしま-, No.38, 10-12, 2005年7月.
17.	山内あい子 : 妊婦·授乳婦と医薬品情報(2), 県薬だより-情報とくしま-, No.37, 1-4, 2005年4月.
18.	山内あい子 : 妊婦·授乳婦と医薬品情報(1), 県薬だより-情報とくしま-, No.36, 5-8, 2005年1月.
19.	山内あい子 : 薬学部と病薬 -薬学部情報薬局の始動-, 徳島県病薬会誌, No.75, 19-20, 2005年1月.
20.	山内あい子 : 食品品目別，日本人の1人1日平均喫食量の算定および将来補正方法の研究Ⅱ, The San-Ei Gen Foundation For Food Chemical Reserch Annual Report, Vol.8, 56-61, 2002年.
21.	山内あい子 : 食品品目別，日本人の1人1日平均喫食量の算定および将来補正方法の研究Ⅰ, The San-Ei Gen Foundation For Food Chemical Reserch Annual Report, Vol.7, 13-24, 2001年.
22.	山内あい子 : シンポジウム『薬学領域における情報インフラの構築とその利用』の話題, 薬事日報日本薬学会特集号, 1999年3月.
23.	山内あい子 : くすりの相互作用と安全性, 第3回徳島大学薬学部卒後教育公開講座要旨集, 13-32, 1997年12月.
24.	山内あい子 : POSと薬剤師, 県薬便り, Vol.14, 24-27, 1997年12月.

国際会議:

1.	Soushi Imani, Youichi Sato, Tatsuya Shimozawa, Teruaki Iwamoto and Aiko Yamauchi : Association analyses between copy numbers of genes in the azoospermia factor c (AZFc) region on the Y chromosome and male infertility, The 13th International Congress of Human genetics, Kyoto, Apr. 2016.
2.	Youichi Sato, Atsushi Tajima, Katsurayama Motoki, Issei Imoto, Aiko Yamauchi and Iwamoto Teruaki : A replication study of four candidate loci for sex hormone levels previously identified by genome-wide association studies, The 13th International Congress of Human Genetics, Kyoto, Apr. 2016.
3.	Masaya Denda, Takuya Morisaki, Jun Yamamoto, Kohei Sato, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : In Cell Labeling of Target Proteins using ''SEAL-tag'', American Peptide Symposium 2015, Florida, Jun. 2015.
4.	Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013.
5.	Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Application of thiol-responsive amino acid to traceable linker for purification and selective labeling of target protein, 23rd American Peptide Symposium, Hawai'i, Jun. 2013.
6.	Youichi Sato, Iwamoto Teruaki, Toshikatsu Shinka, Aiko Yamauchi and Yutaka Nakahori : Seasonal variation on the reproductive characteristics and sperm concentration of Japanese males, 7th Copenhagen Workshop on Endocrine Disrupters, Copenhagen, May 2013.
7.	Youichi Sato, Toshikatsu Shinka, Aiko Yamauchi and Yutaka Nakahori : Overview of the genetic variations in the Y chromosome in the Japanese population, The American Society of Human Genetics, 62nd Annual Meeting, San Francisco, Nov. 2012.
8.	Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Development of a novel chemical probe that enables selective labeling of proteins, The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Kyoto, Oct. 2012.
9.	Yukari Shono, Mami Adachi, Kumiko Sakamoto, Youichi Sato and Aiko Yamauchi : Prediction of drug-induced hepatotoxicity in human using machine learning, The Second Decennial Meeting Between SeoulNational University and The University of Tokushima, Awaji, Dec. 2010.
10.	Yusuke Kikuno, Mami Adachi, Kumiko Sakamoto, Masaru Kihara and Aiko Yamauchi : Analysis of compounds with developmental toxicity in human and prediction of fetotoxicity using Support Vector Machines, The 8th China-Japan Joint Syposium on Drug Design and Development, Kobe, Nov. 2008.
11.	Aiko Yamauchi, Kaori Nakai, Sayako Doi, Kumiko Sakamoto and Masaru Kihara : Clinical QSAR Study on Placental Drug Transfer and An In Vitro Evaluation Model Using Human Placental JEG-3 Cells, The 8th China-Japan Joint Syposium on Drug Design and Development, Kobe, Nov. 2008.
12.	Aiko Yamauchi, Kumiko Sakamoto, Eiko Doolin Nakata, Makoto Tani, Mikio Sasaki and Hiroshi Chuman : Constructing a web-based drug-teratogenicity information sharing system, anzen-drug com, 8th INTERNATIONAL ISSX MEETING, Sendai, Oct. 2007.
13.	Hideki Uchimi, Kumiko Sakamoto, Makoto Tani, Mikio Sasaki, Aiko Yamauchi and Hiroshi Chuman : Estimating potential risks of pharmaceuticals human fetuses by SimScore in a teratogenicity information sharing system, 8th INTERNATIONAL ISSX MEETING, Sendai, Oct. 2007.
14.	Kumiko Sakamoto, Yuki Hibino, Shuji Yamano, Kazuhisa Maeda, Minoru Irahara and Aiko Yamauchi : Prescription drug use during pregnancy in Japan, 34th Annual Conference of the European Teratology Society, Abano Terme, Sep. 2006.
15.	Aiko Yamauchi, Kumiko Sakamoto and Hiroshi Chuman : Clinical QSAR study on the prediction of drug excretion into human breast milk, 13th NA ISSX Meeting/20th JSSX Meeting, Maui, Oct. 2005.
16.	Aiko Yamauchi : Datebase-construction for teratogenic drugs/medicinal products, Free University , Molecular Toxicology Laboratory meeting, Amsterdam, Sep. 2005.
17.	Aiko Yamauchi and Hiroshi Chuman : Data mining approach on clinical/pharmaceutical information accumulated in the drug safety information community, The First International Conference on Complex Medical Engineering-CME2005, Takamatsu, May 2005.
18.	AHMAD AMMAR GHAIBEH, Mikio Sasaki, Eiko Doolin Nakata, Kumiko Sakamoto, Hiroshi Chuman and Aiko Yamauchi : Using computational intelligence methods in a web-based drug safety information community, The First International Conference on Complex Medical Engineering-CME2005, Takamatsu, May 2005.
19.	Aiko Yamauchi, Kumiko Sakamoto, Hiroshi Chuman, Eiko Nakata Doolin and Mikio Sasaki : Construction of a drug safety information system for pregnant women, Pharmacy and Pharmaceutical Sciences World Congress 2004, 64th International Congress of FIP, New Orleans, Sep. 2004.
20.	Aiko Yamauchi, Eiko Nakata Doolin, Kumiko Sakamoto, Hiroki Goto, Mikio Sasaki and Hiroshi Chuman : Construction of a drug safety information community in Japan, 7th International ISSX Meeting, Vancouver, Aug. 2004.
21.	Aiko Yamauchi, Kumiko Sakamoto, Hiroshi Chuman, Eiko Nakata Doolin, Mikio Sasaki and Hiroki Goto : Construction of a drug safety information community for drug therapy in pregnancy, Pharmaceutical Sciences World Congress (PSWC2004), Kyoto, May 2004.
22.	Daisuke Itokawa, Ryoma Murakami, Aiko Yamauchi and Hiroshi Chuman : Physicochemical analyses of binding activity between cytochrome P450 and azole fungicides, The 10th Japan-Korea Joint Symposium on Drug Design and Development, Tokushima, Apr. 2004.
23.	Takashi Fujiwara, Yuki Hibino, Masaru Kihara, Aiko Yamauchi and Hiroshi Chuman : QSAR analysis for prediciton drug transfer into human breast milk, The 10th Japan-Korea Joint Symposium on Drug Design and Development, Tokushima, Apr. 2004.
24.	Aiko Yamauchi, Hiroshi Chuman, Eiko Doolin Nakata, Hiroki Goto and Mikio Sasaki : Construction of a drug safety information communit, RISTEX International Workshop, Tokyo, Dec. 2003.
25.	Aiko Yamauchi, Takashi Fujiwara, Masaru Kihara and Hiroshi Chuman : QSAR analysis and prediction of drug excretion into human breast milk, Fifth AFMC International Medicinal Chemistry Symposium (AIMECS 03), Kyoto, Oct. 2003.
26.	Aiko Yamauchi : Construction of the growing information-community for teratogenic agents, 徳島大学薬学部ソウル大學薬學大學学術交流講演会, Seoul, Jan. 2003.
27.	Aiko Yamauchi and Eiko Doolin Nakata : Construction of the growing information-community for teratogenic agents in Japan, 12th International Conference of Women Engineers and Scientists, Ottawa, Jul. 2002.
28.	Aiko Yamauchi : Construction of the growing information community for teratogenic agents, The eighth GINC Tokyo Meeting "GINC and Capacity Building for Management of Chemicals in Asia-Pacific Countries", Tokyo, Jul. 2002.
29.	Nobuhiko Ueda, Aiko Yamauchi, Masaru Kihara and Shinsaku Nito : Biotransformation of N-acetyl-L-cysteine: tissue distribution and species difference of its deacetylation, 10th North American ISSX Meeting, Indianapolis, Oct. 2000.

国内講演発表:

1.	大谷知子, 賀勢泰子, 國友一史, 下岡和美, 川添和義, 佐藤陽一, 山内あい子 : 寝たきり高齢患者の腎機能を評価するための血清クレアチニン値の補正方法に関する検討, 第13回日本腎臓病薬物療法学会学術集会・総会, 2019年11月.
2.	小薬鈴, 佐藤陽一, 田嶋敦, 佐藤丈寛, 井本逸勢, 岩本晃明, 山内あい子 : GWASによる血中inhibin Bレベル関連遺伝子座の探索, ConBio2017, 2017年12月.
3.	木口美沙妃, 佐藤陽一, 田嶋敦, 佐藤丈寛, 井本逸勢, 岩本晃明, 山内あい子 : GWASによる精子濃度の関連遺伝子座の探索, ConBio2017, 2017年12月.
4.	長谷川知世, 佐藤陽一, 岩本晃明, 山内あい子 : DPF3，TUSC1およびIZUMO3遺伝子上のSNPと男性不妊症との関連解析, ConBio2017, 2017年12月.
5.	佐藤陽一, 古城公佑, 内田将央, 土屋春樹, 野崎瑞貴, 岩本晃明, 山内あい子 : 家系を対象とした次世代シーケンス解析による新規無精子症原因遺伝子同定の試み, 第62回日本生殖医学会学術講演会, 2017年11月.
6.	福永千香, 佐藤陽一, 岩本晃明, 山内あい子 : 日本人を対象としたメチレンテトラヒドロ葉酸還元酵素遺伝子C677T多型と男性不妊症との関連解析, 第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2017年10月.
7.	谷垣雄都, 佐藤陽一, 山口裕大, 岡田直人, 中村信元, 賀川久美子, 藤井志朗, 三木浩和, 石澤啓介, 安倍正博, 山内あい子 : テイコプラニン投与による副作用発現および血中濃度とCYP遺伝子多型との関連解析, 第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2017年10月.
8.	田島穂澄, 佐藤陽一, 岡田直人, 中村信元, 賀川久美子, 藤井志朗, 三木浩和, 石澤啓介, 安倍正博, 山内あい子 : シタラビン投与による副作用発現と代謝経路関連遺伝子多型の関連解析, 第56回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2017年10月.
9.	Matsuoka Koki, AHMAD AMMAR GHAIBEH, Omura Shiro, Youichi Sato, Hiroki Moriguchi and Aiko Yamauchi : Integrated analysis for drug toxicities in human using multi-label classification., CBI学会2017年大会, Oct. 2017.
10.	山内あい子 : くらしに役立つ薬の知識, 徳島県消費者大学校公開講座, 2017年7月.
11.	大森理央, 佐藤陽一, 木口美沙妃, 岡田直人, 中村信元, 賀川久美子, 藤井志朗, 三木浩和, 石澤啓介, 安倍正博, 山内あい子 : ビンクリスチンによる副作用発現とMDR1遺伝子多型との関連性, 第20回日本医薬品情報学会総会・学術大会, 2017年7月.
12.	山口裕大, 佐藤陽一, 谷垣雄都, 岡田直人, 中村信元, 賀川久美子, 藤井志朗, 三木浩和, 石澤啓介, 安倍正博, 山内あい子 : バンコマイシン投与による副作用発現及び血中濃度とCYP遺伝子多型との関連解析, 第20回日本医薬品情報学会総会・学術大会, 2017年7月.
13.	岡島八千代, 佐藤陽一, 山内あい子 : 日本人の食品品目別一日喫食量の将来予測, 日本食品化学学会第23回総会・学術大会, 2017年6月.
14.	山内あい子 : 「くすりを正しく安全に使うための基礎知識」, 徳島市消費者協会総会, 2017年5月.
15.	山本清威, 水口博之, 渡嘉敷夏海, 小林誠, 佐藤陽一, 藤野裕道, 福井裕行, 山内あい子 : 膵α細胞からのグルカゴン分泌に関与するPKCアイソザイムの同定, 日本薬学会第137年会, 2017年3月.
16.	山内あい子 : 『妊婦・授乳婦への薬学的ケアの基礎知識その2』, 徳島県薬剤師会鳴門支部研修会, 2016年12月.
17.	山内あい子 : 『妊婦・授乳婦への薬学的ケアの基礎知識その1』, 徳島県薬剤師会鳴門支部研修会, 2016年11月.
18.	松田実紗, 岡田直人, 佐藤陽一, 山内あい子, 川添和義 : DPP4遺伝子多型と肥満との関連解析, 第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2016年11月.
19.	山西愛実, 岡田直人, 佐藤陽一, 山内あい子, 川添和義 : インクレチンホルモン及びその受容体の遺伝子多型と肥満との関連解析, 第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2016年11月.
20.	大村士朗, 松岡恒輝, 佐藤陽一, 山内あい子, ガイベアハマドアンマール, 森口博基 : Support Vector Machine及び決定木による化合物のヒト発がん性予測モデルの構築, 第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2016年11月.
21.	大谷知子, 賀勢泰子, 國友一史, 下岡和美, 山本浩子, 川添和義, 佐藤陽一, 山内あい子 : 寝たきり高齢者における腎機能評価に影響を与える因子の検討, 第24回日本慢性期医療学会, 2016年10月.
22.	Matsuoka Koki, AHMAD AMMAR GHAIBEH, Omura Shiro, Youichi Sato, Hiroki Moriguchi and Aiko Yamauchi : "Prediction of chemical-induced developmental and reproductive toxicity in human using the machine learning", CBI学会2016年大会, Oct. 2016.
23.	山本清威, 水口博之, 小林誠, 佐藤陽一, 福井裕行, 山内あい子 : 膵α細胞からのグルカゴン分泌に対するquercetinの効果, 日本薬学会第136年会, 2016年3月.
24.	今仁聡志, 佐藤陽一, 下澤辰也, 岩本晃明, 山内あい子 : Y染色体上azoospermia factor c (AZFc) 領域内に存在する遺伝子のコピー数と男性不妊症との関連解析, 第38回日本分子生物学年会・第88回日本生化学会大会合同大会, 2015年12月.
25.	山内あい子 : 女性研究者のキャリアパスについて考える，自分らしく輝くために!, 講演会「化学系女子の進路と大学院進学」, 2015年11月.
26.	松岡恒輝, 佐藤陽一, 大髙章, 山内あい子 : 薬物の胎児毒性に関する機械学習による予測と化学構造特性の解析, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2015年11月.
27.	辻弥生, 佐藤陽一, 川添和義, 山内あい子, 石澤啓介 : NSAIDsの種類及び服薬期間，頻度と発癌リスクに関するメタ解析, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2015年11月.
28.	山本清威, 水口博之, 小林誠, 佐藤陽一, 福井裕行, 山内あい子 : PKCδシグナル抑制化合物によるグルカゴン分泌抑制効果, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2015年10月.
29.	葛山元貴, 佐藤陽一, 田嶋敦, 井本逸勢, 岩本晃明, 山内あい子 : 性ホルモン関連遺伝子座3 SNPsの日本人男性を対象としたreplication解析, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2015年10月.
30.	大谷知子, 賀勢泰子, 國友一史, 川添和義, 佐藤陽一, 山内あい子 : 寝たきり高齢者における腎機能評価 ∼Scr補正の検証∼, 第9回日本腎臓病薬物療法学会学術大会2015, 2015年10月.
31.	傳田将也, 森崎巧也, 猪熊翼, 佐藤陽一, 山内あい子, 重永章, 大髙章 : N-Sアシル基転移反応を基盤としたin cellタンパク質ラベル化法の開発, 第47回若手ペプチド夏の勉強会, 2015年8月.
32.	傳田将也, 森崎巧也, 猪熊翼, 佐藤陽一, 山内あい子, 重永章, 大髙章 : N-Sアシル基転移反応を利用した新規ラベル化試薬の開発, 創薬懇話会2015 in 徳島, 2015年7月.
33.	松岡恒輝, 稲山義高, 大村士朗, 佐藤陽一, 山内あい子 : ヒト胎児に対する薬物の安全性を機械学習により予測する, 第18回日本医薬品情報学会総会・学術大会, 2015年6月.
34.	大谷知子, 賀勢泰子, 山本浩子, 國友一史, 川添和義, 佐藤陽一, 山内あい子 : 高齢者における腎機能評価に影響を与える因子の検討∼実測Ccr と推定Ccr の比較∼, 日本薬学会第135年会, 2015年3月.
35.	川野壮一, 新谷保実, 鈴江朋子, 岡田直人, 佐藤陽一, 山内あい子 : 当院での糖尿病治療におけるDPP-4 阻害薬の有効性と安全性の評価, 日本薬学会第135年会, 2015年3月.
36.	山内あい子 : 中国四国地方から発信する男女共同参画の取組, 第6回中国四国男女共同参画シンポジウム, 2014年11月.
37.	山本純, 森崎巧也, 北未来, 小宮千明, 重永章, 佐藤陽一, 山内あい子, 大髙章 : 標的タンパク質の効率的濃縮および選択的ラベル化を可能とするチオール応答型トレーサブルリンカーの開発, 第32回メディシナルケミストリーシンポジウム, 2014年11月.
38.	佐藤陽一, 常松晃希, 田嶋敦, 井本逸勢, 山内あい子, 岩本晃明 : 男性生殖能力関連候補遺伝子座 4SNPsの日本人男性を対象とした精液パラメータ及び男性不妊症との関連解析, 日本人類遺伝学会第59回大会, 2014年11月.
39.	下澤辰也, 佐藤陽一, 岩本晃明, 山内あい子 : 日本人男性におけるY染色体上DAZ遺伝子の欠失パターンと精液パラメータとの関連解析, 日本人類遺伝学会第59回大会, 2014年11月.
40.	関屋諒, 佐藤陽一, 山内あい子 : Hemoglobinの抗酸化作用による腎機能保護に対するDPP4の影響, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2014年11月.
41.	中西智子, 石澤啓介, 阿部真治, 中瀬真理, 柴田洋文, 佐藤智恵美, 新垣尚捷, 佐藤陽一, 山﨑尚志, 笠原二郎, 東満美, 山﨑哲男, 山内あい子, 滝口祥令, 土屋浩一郎 : アドバンスト演習を通した問題解決能力向上のための症例解析手法の検討-プロダクトからの分析, 日本薬学会第134年会, 2014年3月.
42.	長尾麻以, 佐藤陽一, 山内あい子 : 炎症関連遺伝子多型とNSAIDs服用による発癌抑制に関するメタ解析, 日本薬学会第134年会, 2014年3月.
43.	傳田将也, 山本純, 佐藤浩平, 坂本健, 重永章, 佐藤陽一, 山内あい子, 大髙章 : ラベル化試薬"SEAL-tag"の開発とCOX-1およびhCA1のラベル化, 日本薬学会第134年会, 2014年3月.
44.	森崎巧也, 山本純, 重永章, 佐藤陽一, 猪熊翼, 山内あい子, 大髙章 : 標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発, 日本薬学会第134年会, 2014年3月.
45.	山内あい子 : 自立的取組の成果と課題 ∼意識・組織・財政の面から∼, 第4回四国女性研究者フォーラム, 2013年12月.
46.	山内あい子 : ワークライフバランスを考える, 徳島大学病院診療支援部研修会 WLB講演, 2013年12月.
47.	佐藤浩平, 傳田将也, 山本純, 坂本健, 重永章, 佐藤陽一, 山内あい子, 大髙章 : タンパク質機能解明を指向した新規ラベル化試薬''SEAL-tag''の開発研究, 第31回メディシナルケミストリーシンポジウム, 2013年11月.
48.	山内あい子 : 妊娠・授乳期における薬学的ケアの基礎知識, 益田市薬剤師会学術研修会, 2013年11月.
49.	山内あい子 : 妊婦授乳婦の薬物治療-精神疾患・てんかん, 第二回妊婦授乳婦薬剤研究会, 2013年11月.
50.	中西智子, 石澤啓介, 阿部真治, 中瀬真理, 柴田洋文, 佐藤智恵美, 新垣尚捷, 佐藤陽一, 山﨑尚志, 笠原二郎, 東満美, 山﨑哲男, 山内あい子, 滝口祥令, 土屋浩一郎 : アドバンスト演習を通した問題解決能力向上のための症例解析手法の検討, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2013年10月.
51.	鎌田高宣, 佐藤陽一, 山内あい子 : DPP4欠損ラット及び培養細胞を用いた腎臓におけるDPP4の機能解析, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2013年10月.
52.	岩佐亮佑, 中谷充志, 佐藤陽一, 山内あい子 : ヒト有機アニオントランスポーター3(hOAT3)新規アイソフォームのクローニングと発現解析, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2013年10月.
53.	長尾麻以, 佐藤陽一, 山内あい子 : NSAIDs服用による発癌リスク抑制効果とPPAR 遺伝子多型の影響に関するメタアナリシス, 第23回日本医療薬学会年会, 2013年9月.
54.	山本純, 北未来, 重永章, 佐藤陽一, 山内あい子, 大髙章 : 標的タンパク質精製・選択的ラベル化ツール''Traceable Linker''の開発研究, 生命分子機能研究会2013学術集会, 2013年9月.
55.	山内あい子 : 食の安全薬と食べ物の飲み合わせ, 徳島大学大学開放実践センター同窓会六一会講演会, 2013年9月.
56.	山内あい子 : 『医薬品の正しい使い方』教育と医療の変革, 学校環境衛生・薬事衛生研究協議会, 2013年9月.
57.	長尾麻以, 佐藤陽一, 山内あい子 : インターロイキン遺伝子多型とNSAIDs服用による発癌リスクに関するメタアナリシス, 第16回日本医薬品情報学会総会・学術大会, 2013年8月.
58.	島添隆雄, 山内あい子 : 教育評価手法開発プログラムG4のアンケートから見えてくるもの, 教育評価手法開発シンポジウム, 2013年8月.
59.	山内あい子 : 教育評価手法開発について「大学から」, 教育評価手法開発シンポジウム, 2013年8月.
60.	山本純, 北未来, 重永章, 佐藤陽一, 山内あい子, 大髙章 : 標的タンパク質を釣り上げろ!∼トレーサブルリンカーの開発∼, 第45回若手ペプチド夏の勉強会, 2013年7月.
61.	山内あい子 : 男女共同参画社会の実現と医療の変革, オンリーワンとくしま学講座, 2013年7月.
62.	平田收正, 波多野力, 山内あい子 : 先導的薬剤師養成に向けた実践的アドバンスト教育プログラムの共同開発, 日本薬学会第133回年会, 2013年3月.
63.	島添隆雄, 家入一郎, 山内あい子, 荒井國光, 上島悦子, 平田收正 : 実務実習における教育評価法プログラムとしてのフィードバック事例集の開発, 日本薬学会第133回年会, 2013年3月.
64.	長尾麻以, 佐藤陽一, 山内あい子 : NSAIDs服用による発癌抑制とIL遺伝子多型の影響に関するメタ解析, 日本薬学会第133回年会, 2013年3月.
65.	鎌田高宣, 佐藤陽一, 山内あい子 : 腎機能障害発症におけるDPP4の関わり, 日本薬学会第133回年会, 2013年3月.
66.	山本純, 北未来, 重永章, 佐藤陽一, 山内あい子, 大髙章 : 標的タンパク質の精製・選択的ラベル化ツール「トレーサブルリンカー」の開発, 日本薬学会第133回年会, 2013年3月.
67.	山内あい子 : 妊婦・授乳婦に対する薬学的ケアの基礎知識 -安心した薬物療法を行うために-, 第1回妊婦・授乳婦薬物療法研修会, 2013年3月.
68.	山内あい子 : 女性研究者支援ネットワーク, 第23回手づくり研修(大塚製薬工場研究開発センター), 2013年2月.
69.	山内あい子 : 食薬相互作用, 第23回手づくり研修(大塚製薬工場研究開発センター), 2013年2月.
70.	山本純, 傳田将也, 戎野紘司, 重永章, 佐藤陽一, 山内あい子, 大髙章 : フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製実験, 第30回メディシナルケミストリーシンポジウム, 2012年11月.
71.	中西智子, 佐藤陽一, 山内あい子, 土屋浩一郎 : 薬学部での臨床思考プロセスを取り入れた医薬品情報提供実習, 51回日本薬学会・日本薬剤師会，日本病院薬剤師会中国四国支部学術大会, 2012年11月.
72.	傳田将也, 山本純, 坂本健, 重永章, 佐藤陽一, 山内あい子, 大髙章 : タンパク質選択的ラベル化法の開発研究, 第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会, 2012年11月.
73.	鍋島亜季, 瀧澤みのり, 土居沙也子, 坂本久美子, 佐藤陽一, 山内あい子 : ヒト胎盤絨毛細胞培養モデルによる薬物の胎盤通過性評価, 51回日本薬学会・日本薬剤師会，日本病院薬剤師会中国四国支部学術大会, 2012年11月.
74.	鍛冶貴久, 佐藤陽一, 山内あい子 : 肥満発症とプロテアソーム活性の関連性, 51回日本薬学会・日本薬剤師会，日本病院薬剤師会中国四国支部学術大会, 2012年11月.
75.	山内あい子 : 未来につなげる女性研究者支援体制, 第3回四国女性研究者フォーラム, 2012年11月.
76.	長尾麻以, 佐藤陽一, 山内あい子 : NSAIDs服用による発癌抑制とCOX遺伝子多型の影響に関するメタアナリシス, 第22回日本医療薬学会年会, 2012年10月.
77.	岩出あゆみ, 吉田奈央, 坂本久美子, 佐藤陽一, 山内あい子 : 妊婦・授乳婦の漢方薬治療に関する安全性情報データベースの構築, 第22回日本医療薬学会年会, 2012年10月.
78.	中島裕登, 稲山義高, 佐藤陽一, 山内あい子 : 薬物性腎障害に関する医薬品副作用情報の解析と機械学習による安全性予測, 第15回日本医薬品情報学会総会・学術大会, 2012年7月.
79.	長尾麻以, 佐藤陽一, 山内あい子 : COX-2遺伝子多型とNSAIDs服用による発がんリスクに関するメタアナリシス, 第15回日本医薬品情報学会総会・学術大会, 2012年7月.
80.	庄野由佳理, 足立麻美, 坂本久美子, 佐藤陽一, 山内あい子 : 副作用情報に基づく薬物性肝障害惹起医薬品の分類と機械学習による安全性予測, 第15回日本医薬品情報学会総会・学術大会, 2012年7月.
81.	傳田将也, 山本純, 佐藤浩平, 坂本健, 重永章, 佐藤陽一, 吉村好之, 山内あい子, 大髙章 : 新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究, 日本ケミカルバイオロジー学会第7回年会, 2012年6月.
82.	山本純, 傳田将也, 戎野紘司, 重永章, 佐藤陽一, 山内あい子, 大髙章 : フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製法の開発, 日本ケミカルバイオロジー学会第7回年会, 2012年6月.
83.	吉田奈央, 村上貴子, 植村紘子, 小林理, 坂本久美子, 佐藤陽一, 山内あい子 : 妊婦と授乳婦の漢方薬治療における安全性情報データベースの構築, 第33 回徳島大学薬学部卒後教育公開講座, 2011年12月.
84.	長尾麻以, 佐藤陽一, 山内あい子 : NSAIDs 服用による発癌リスク抑制効果とCOX-2 遺伝子多型の影響に関するメタアナリシス, 第33 回徳島大学薬学部卒後教育公開講座, 2011年12月.
85.	中西智子, 佐藤陽一, 山内あい子, 土屋浩一郎 : 問題解決能力の向上を目指した病院実務実習を考える, 第33 回徳島大学薬学部卒後教育公開講座, 2011年12月.
86.	中西智子, 佐藤陽一, 山内あい子, 土屋浩一郎 : 問題解決能力の向上を目指した病院実務実習を考える, 第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国支部学術大会, 2011年11月.
87.	山内あい子 : 「くすりを正しく安全に使って，健やかに」, 薬と健康講演会, 2011年10月.
88.	佐藤陽一, 中西智子, 山内あい子 : 薬学部教員が病院実習「情報を正しく使う」を実施して, 第21回日本医療薬学会年会, 2011年10月.
89.	山内あい子, 坂本久美子, 佐藤陽一 : 薬物の乳汁移行性予測について, 第14回日本医薬品情報学会, 2011年7月.
90.	佐藤陽一, 中西智子, 山内あい子 : 初年度の病院実習「情報を正しく使う」を担当して, 第14回日本医薬品情報学会, 2011年7月.
91.	吉田奈央, 佐藤陽一, 山内あい子 : 妊婦・授乳婦のための漢方安全性情報データベースの構築, 第14回日本医薬品情報学会総会・学術大会, 2011年7月.
92.	山内あい子 : 妊婦・授乳婦への薬学的ケアにおける基礎知識, 山口県病院薬剤師会薬学研究会第169回例会特別講演, 2011年6月.
93.	佐藤陽一, 中西智子, 山内あい子 : 初年度の病院実習「情報を正しく使う」を担当して, 日本薬学会131年会, 2011年3月.
94.	佐藤陽一, 山内あい子 : 初年度の病院実習「情報を正しく使う」を担当して, 第31回徳島大学卒後教育公開講座, 2010年12月.
95.	石澤啓介, 中西智子, 柴田洋文, 阿部真治, 杉村真由美, 奥村千恵子, 吉村好之, 佐藤陽一, 新垣尚捷, 川添和義, 東満美, 土屋浩一郎, 山内あい子, 山﨑哲男, 水口和生 : 徳島大学における薬学部・薬剤部連携による病院実務実習の実践, 第20回日本医療薬学会年会, 2010年11月.
96.	庄野由佳理, 足立麻美, 坂本久美子, 佐藤陽一, 山内あい子 : 副作用情報に基づく薬物性肝障害惹起医薬品の分類と機械学習による安全性予測, 第38回構造活性相関シンポジウム, 2010年10月.
97.	山内あい子 : 「妊婦・授乳婦に対する薬学的ケアの基礎知識」, 愛媛県病院薬剤師会特別講演会, 2010年5月.
98.	坂東志津子, 満友良介, 小川壮寛, 高橋正志, 松下明, 山内あい子 : ポートフォリオ導入による地域薬局の糖尿病治療支援活動とその評価, 日本薬学会130年会, 2010年3月.
99.	岡本崇, 三輪祐太朗, 坂本久美子, 山内あい子 : 化合物の化学構造と代謝情報を用いたヒト発癌性予測のためのSVM モデルの構築, 日本薬学会130年会, 2010年3月.
100.	石澤啓介, 川添和義, 東満美, 土屋浩一郎, 山内あい子, 山﨑哲男, 水口和生, 中西智子, 柴田洋文, 阿部真治, 杉村真由美, 奥村千恵子, 吉村好之, 佐藤陽一, 新垣尚捷 : P1-571 徳島大学における薬学部・薬剤部連携による病院実務実習の実践(一般演題ポスター発表,薬学教育(実務実習),臨床から学び臨床へと還元する医療薬学), 日本医療薬学会年会講演要旨集, Vol.20, No.0, 382, 2010年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390845713041900800 (CiNii: 1390845713041900800)
101.	岡本崇, 三輪祐太朗, 坂本久美子, 山内あい子 : In silicoで化学物質のヒト発癌性は予測できるか?, 第29回徳島大学卒後教育公開講座, 2009年12月.
102.	Yutarou Miwa, Kumiko Sakamoto and Aiko Yamauchi : Analysis of carcinogenic compounds and prediction model using Support Vector Machine, 第37回構造活性相関シンポジウム, Nov. 2009.
103.	三輪祐太朗, 岡本崇, 坂本久美子, 山内あい子 : 化合物のヒト発癌性に関する情報科学的解析と予測, 第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, 2009年11月.
104.	小林理, 髙田裕介, 坂本久美子, 木原勝, 山内あい子 : 妊娠・授乳期の漢方薬治療における安全性情報データベースの構築, 日本薬学会129年会, 2009年3月.
105.	土居沙也子, 中井香, 宇髙沙耶佳, 坂本久美子, 木原勝, 山内あい子 : 薬物の胎盤通過性を評価するヒト胎盤細胞培養モデルの作成, 日本薬学会129年会, 2009年3月.
106.	三輪祐太朗, 坂本久美子, 木原勝, 山内あい子 : Support Vector Machine による化合物のヒト発癌性予測の試み, 日本薬学会129年会, 2009年3月.
107.	足立麻美, 菊野裕介, 髙田裕介, 木原勝, 山内あい子 : 医薬品副作用情報に基づく薬物性肝障害惹起薬物の解析と分類, 日本薬学会129年会, 2009年3月.
108.	高田裕介, 山内あい子, 木原勝 : ノルエピネフリン増強作用を有する化合物の構造活性相関, 日本薬学会129年会, 2009年3月.
109.	足立麻実, 菊野裕介, 高田裕介, 木原勝, 山内あい子 : 薬物性肝障害に関する医薬品副作用情報の解析, 第27回徳島大学卒後教育公開講座, 2008年12月.
110.	小林理, 高田裕介, 木原勝, 山内あい子 : 妊婦・授乳婦の漢方治療薬における安全性情報データベースの構築, 第27回徳島大学卒後教育公開講座, 2008年12月.
111.	中井香, 土居沙也子, 坂本久美子, 木原勝, 山内あい子 : 薬物の胎盤通過性に関するClinicalQSAR解析とヒト胎盤培養細胞モデルの作成, 第47回日本薬学会，日本薬剤師会，日本病院薬剤師会中国四国支部学術大会, 2008年11月.
112.	Yusuke Kikuno, Mami Adachi, Kumiko Sakamoto, Masaru Kihara and Aiko Yamauchi : Analysis of compounds with developmental toxicity in human and prediction of fetotoxicity using Support Vector Machines, 第36回構造活性相関シンポジウム, Nov. 2008.
113.	山内あい子 : 『薬物治療に影響する食薬相互作用を考える-飲食物・嗜好品・健康食品と薬の飲み合わせ-』, 第156回名西郡・名東郡学術講演会, 2008年6月.
114.	高田裕介, 矢野麻衣子, 原田恵, 山内あい子, 木原勝 : エタノールアミンおよびピペリジン誘導体の合成とノルエピネフリン増強作用の検討, 日本薬学会第128年会, 2008年3月.
115.	山内あい子 : 社会にも家庭にも活かしたい理系女性の科学的視点, 徳島県医師会女性医師部会講演会「生涯いかそう，あなたの才能とキャリア」, 2007年12月.
116.	菊野裕介, 坂本久美子, 内見秀樹, 木原勝, 山内あい子 : ヒト胎児毒性既知化合物の情報化学的分類, 第25回徳島大学卒後教育公開講座, 2007年12月.
117.	阿部覚, 吉田麻衣, 坂和園子, 木原勝, 山内あい子, 内藤真策 : QSAR解析によるセフェム系抗生物質のラット脳脊髄腔液移行性評価, 第25回徳島大学卒後教育公開講座, 2007年12月.
118.	中井香, 日比野有紀, 坂本久美子, 木原勝, 山内あい子 : 情報科学的手法を用いた医薬品の胎児移行性評価, 第25回徳島大学卒後教育公開講座, 2007年12月.
119.	植村紘子, 村上貴子, 堀田理文, 木原勝, 山内あい子 : 妊娠・授乳期の漢方薬療法に関する完全性情報データベース, 第25回徳島大学卒後教育公開講座, 2007年12月.
120.	坂東志津子, 増冨直子, 藤本浩之, 堀正二, 高橋正志, 曽田高広, 吉井清治, 山内あい子 : 地域保険薬局における効果的なファーマシューティカル・ケアの実践:定期来局患者および処方箋調剤に関する実態調査とその解析, 第25回徳島大学卒後教育公開講座, 2007年12月.
121.	竹崎俊晶, 小林進一, 坂本久美子, 木原勝, 山内あい子 : IARC 分類に基づく発癌性化合物の解析とSupport Vector Machine によるヒト発癌性予測, 第35回構造活性相関シンポジウム, 2007年11月.
122.	吉田麻衣, 坂和園子, 阿部覚, 木原勝, 内藤真策, 山内あい子 : セフェム系抗生物質のラット脳脊髄腔液移行性に関するQSAR解析, 第35回構造活性相関シンポジウム, 2007年11月.
123.	糸川大祐, 山内あい子, 中馬寛 : アゾール系化合物のCYP2B/3Aとの結合および酵素活性阻害様式の解析 (2), 第35回構造活性相関シンポジウム, 2007年11月.
124.	東満美, 日野出晴美, 柏田良樹, 吉田昌裕, 山﨑尚志, 土屋浩一郎, 山内あい子, 柴田洋文, 新垣尚捷, 滝口祥令, 荒木勉, 吉村好之, 姫田敏樹, 石田竜弘, 辻大輔, 木原勝 : 徳島大学薬学部OSCEトライアル実施体制の確立と検証, 第17回日本医療薬学会年会, 2007年9月.
125.	中井香, 日比野有紀, 坂本久美子, 木原勝, 山内あい子 : 薬物のヒト胎盤通過性に関する構造活性相関解析と妊婦に処方された医薬品の胎児移行性評価, 第17回日本医療薬学会年会, 2007年9月.
126.	坂東志津子, 増冨直子, 末田芳裕, 藤本浩之, 堀正二, 高橋正志, 曽田高広, 吉井清治, 山内あい子 : 地域保険薬局における定期来局患者および処方箋調剤に関する実態調査とファーマシューティカル・ケアの実践, 第17回日本医療薬学会年会, 2007年9月.
127.	吉田麻衣, 坂和園子, 阿部覚, 木原勝, 内藤真策, 山内あい子 : 注射用セフェム系抗生物質のラット脳脊髄腔液移行性評価, 第17回日本医療薬学会年会, 2007年9月.
128.	山内あい子 : 薬食相互作用から健康食品を考える, 第235回徳島医学会学術集会シンポジウム講演, 2007年8月.
129.	山口佳津騎, 山本敦司, 實光由香, 山内あい子, 木原勝 : 3,4-diphenyl-1,2-dihydroquinoline 2,3-diphenylindole, 日本薬学会第127年会要旨集, 2007年3月. (キーワード) 乳癌細胞増殖抑制作用 / インドール誘導体 / 分子内閉環反応
130.	山口佳津騎, 山本敦司, 實光由香, 山内あい子, 木原勝 : 乳癌細胞増殖抑制作用を志向する3,4-diphenyl-1,2-dihydroquinolineおよび2,3-diphenylindole 誘導体の合成, 日本薬学会第127年会, 2007年3月.
131.	矢野麻衣子, 原田恵, 生田雅子, 高田裕介, 梶谷育代, 秋本夏奈, 山内あい子, 木原勝 : ピペリジンおよびエタノールアミン誘導体の合成とノルエピネフリン増強作用, 日本薬学会第127年会, 2007年3月.
132.	山内あい子 : 妊娠と薬に関する医薬品安全性情報コミュニティの紹介, 第13回徳島大学臨床薬剤師交流ネットワーク研修会, 2007年2月.
133.	佐藤幸司, 川崎直美, 坂本久美子, 山内あい子, 木原勝 : 食品品目別，日本人1人1日あたりの平均喫食量に関する検討, 第23回徳島大学薬学部卒後教育公開講座, 2006年12月.
134.	坂本久美子, 佐々木幹夫, 中馬寛, 山内あい子 : 医薬品安全性情報コミュニティサイトにようこそ!, 第23回徳島大学薬学部卒後教育公開講座, 2006年12月.
135.	堀田理文, 大恵眉美, 東満美, 徳田あゆみ, 坂本久美子, 山内あい子 : 医薬品商品名の由来データベースの作成, 第23回徳島大学薬学部卒後教育公開講座, 2006年12月.
136.	山内あい子 : 「妊娠と薬」に関連した医薬品安全性情報コミュニティの始動, 第32回情報処理技術検討交換会, 2006年12月.
137.	山内あい子 : 医薬品安全性情報コミュニティの構築にむけて, JST・RISTEX領域シンポジウム(平成15年度採択課題研究終了報告), 2006年11月.
138.	山内あい子, 坂本久美子, 中田栄子, 佐々木幹夫, ガイベアハマドアンマール, 中馬寛 : 医薬品安全性情報コミュニティ・データベースシステム:妊娠と薬に関する安全性情報の共有に向けて, INFOPRO2006, 2006年11月.
139.	谷真琴, ガイベアハマドアンマール, 佐々木幹夫, 坂本久美子, 中馬寛, 山内あい子 : 分子構造類似性に基く催奇形性予測ソフトウェア(Simscore), SAR2006 第34回構造活性相関シンポジウム, 2006年11月.
140.	糸川大祐, 西岡大貴, 福島淳治, 安田知世, 山内あい子, 中馬寛 : アゾール系化合物のCYP2B/3Aとの結合および酵素活性阻害様式の解析, SAR2006 第34回構造活性相関シンポジウム, 2006年11月.
141.	坂本久美子, 中馬寛, 山内あい子, 谷真琴, ガイベアハマドアンマール, 佐々木幹夫 : 構造類似度算出機構(SimScore)を備えた薬物催奇形性情報システム, SAR2006 第34回構造活性相関シンポジウム, 2006年11月.
142.	山内あい子 : 妊娠に関連した医薬品安全性情報コミュニティの始動, JST・RISTEX 『医薬品安全性情報コミュニティの構築にむけて』最終報告講演会, 2006年10月.
143.	山口佳津騎, 山本敦司, 山内あい子, 木原勝 : 腫瘍細胞増殖抑制活性を有する2,3-ジフェニルインドール誘導体の合成, 第45回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 2006年10月.
144.	山内あい子, 坂本久美子, 中田栄子, 佐々木幹夫, ガイベアハマドアンマール, 中馬寛 : 医薬品安全性情報コミュニティの紹介, 第16回医療薬学会年会, 2006年9月.
145.	坂本久美子, 中田栄子, 佐々木幹夫, ガイベアハマドアンマール, 中馬寛, 山内あい子 : 医薬品安全性情報コミュニティにおける薬物催奇形性情報データベースの試験公開, 第16回医療薬学会年会, 2006年9月.
146.	大恵眉美, 堀田理文, 東満美, 徳田あゆみ, 坂本久美子, 山内あい子 : 医薬品商品名の由来データベースの作成と医療薬学教育への応用, 第16回医療薬学会年会, 2006年9月.
147.	山内あい子 : 医薬品の安全性, 徳島YUクラブミニ9月講演会, 2006年9月.
148.	山口佳津騎, 山本敦司, 山内あい子, 木原勝 : 抗乳がん剤を志向する3,4-ジフェニル-1,2-ジヒドロキノリンおよび2,3-ジフェニルインドール誘導体の合成, 第7回長井長義記念シンポジウム, 2006年9月.
149.	Kumiko Sakamoto, Eiko Nakata Doolin, Mikio Sasaki, ガイベアハマドアンマール, 中馬寛, 山内あい子 : A Web-Based Drug Safety Information Community, CBI学会2006年大会, 2006年7月.
150.	山内あい子 : 医薬品安全性情報コミュニティの紹介, 国立大学法人徳島大学薬友会近畿支部総会及び大阪サテライトオフィス合同交流会, 2006年7月.
151.	山内あい子 : 薬剤師のためのPOS·SOAP実践講座, 第6回徳島大学臨床薬剤師交流ネットワーク研修会, 2006年5月.
152.	小林進一, 坂本久美子, Lepp Zsolt, 山内あい子, 中馬寛 : パターン認識手法による薬物の胎児毒性予測の試み, 日本薬学会第126年会, 2006年3月.
153.	山内あい子 : 女性のライフサイクルと薬物治療, JST・RISTEXシンポジウム -女性のライフサイクルと薬物治療-, 2005年12月.
154.	坂本久美子, 日比野有紀, 木原勝, 山内あい子 : 徳島大学病院における妊婦への処方実態調査, 第21回徳島大学薬学部卒後教育公開講座, 2005年12月.
155.	Xiangli Liu, 田中秀治, 山内あい子, Bernard Testa, 中馬寛 : Determination of lipophilicity by reversed-phase high-performance liquid chromatography (RP-HPLC), 第33回構造活性相関シンポジウム, 2005年11月.
156.	小林進一, 坂本久美子, 山内あい子, 中馬寛 : Support Vector Machine 手法に基づく薬物催奇形性リスク予測の試み, 第33回構造活性相関シンポジウム, 2005年11月.
157.	日比野有紀, 坂本久美子, 小林進一, 木原勝, 中馬寛, 山内あい子 : 薬物の胎盤通過性と母乳移行性予測-ClinicalQSAR (3), 第33回構造活性相関シンポジウム, 2005年11月.
158.	糸川大祐, 村上良真, 西岡大貴, 福島淳冶, 山内あい子, 中馬寛 : CYP2B, 3Aおよび51とアゾール系化合物との結合相互作用の解析, 第33回構造活性相関シンポジウム, 2005年11月.
159.	矢野麻衣子, 原田恵, 秋本夏奈, 山内あい子, 木原勝 : フェニルピペリジン誘導体のノルエピネフリン増強作用の検討 2, 第44回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2005年11月.
160.	山内あい子 : 食べ物と薬の危険な関係, 徳島大学大学院ヘルスバイオサイエンス研究部市民講演会, 2005年10月.
161.	日比野有紀, 坂本久美子, 小林進一, 木原勝, 中馬寛, 山内あい子 : QSARによるヒトにおける薬物の胎盤通過性と母乳移行性予測:Clinical QSARの試み, 日本コンピュータ化学会2005秋季年会, 2005年10月.
162.	坂本久美子, 中田栄子, 佐々木幹夫, ガイベアハマドアンマール, 中馬寛, 山内あい子 : 医薬品安全性情報コミュニティの構築-薬物催奇形性情報の共有に向けて-, 日本コンピュータ化学会2005秋季年会, 2005年10月.
163.	山内あい子 : 医薬品安全性予測のための臨床情報解析における情報化学の果たす役割, 日本コンピュータ化学会2005秋季年会, 2005年10月.
164.	坂本久美子, 日比野有紀, 木原勝, 山野修司, 前田和寿, 苛原稔, 山内あい子 : 徳島大学病院における妊婦に対する処方医薬品とその胎児危険度評価, 第15回日本医療薬学会年会, 2005年10月.
165.	小林進一, 坂本久美子, Zsolt Lepp, 山内あい子, 中馬寛 : Support Vector Machine を用いたヒトにおける薬物催奇形性予測の試み, 日本コンピュータ化学会2005秋季年会, 2005年10月.
166.	生田賢治, 西村益弘, 上田信彦, 内藤真策, 李英培, 清水英治, 木原勝, 山内あい子 : ヒト非小細胞肺癌細胞の抗癌剤耐性機構-アポトーシスおよびSTATとの関連-, 第6回長井長義記念シンポジウム, 2005年7月.
167.	山口佳津騎, 永井美由紀, 山内あい子, 木原勝 : 抗乳がん剤を志向する3,4-ジフェニル-1,2,3,4-テトラヒドロキノリン誘導体の合成, 第6回長井長義記念シンポジウム, 2005年7月.
168.	山口真理, 山内あい子, 西村益浩, 上田信彦, 内藤真策 : 幼若ラットにおける無脂肪TPNによる肝障害の発生機序脂肪配合の効果-糖·脂肪代謝酵素mRNAからの検討-, 日本薬学会第125年会, 2005年3月.
169.	西村益浩, 山内あい子, 山口真理, 上田信彦, 内藤真策 : 幼若ラットへの無脂肪TPNによるトランスポーターなどのmRNA発現低下に対する脂肪配合の効果, 日本薬学会第125年会, 2005年3月.
170.	日比野有紀, 坂本久美子, 木原勝, 山内あい子, 山野修司, 前田和寿, 苛原稔 : 徳島大学病院における妊婦に対する医薬品使用状況調査, 日本薬学会第125年会, 2005年3月.
171.	坂本久美子, 神部順子, 中田栄子, 佐々木幹夫, 後藤尋規, 中馬寛, 山内あい子 : 医薬品安全性情報コミュニティの構築にむけた「妊娠と薬」に関する意識調査 -薬剤師,薬学生,研究者の場合-, 第27回情報化学討論会, 2004年12月.
172.	原田恵, 秋本夏奈, 生田雅子, 永井美由紀, 久山哲廣, 山内あい子, 木原勝 : 3-および4-フェニルピペリジン誘導体のノルエピネフリン増強作用の検討, 第42回日本薬学会·日本病院薬剤師会中国四国支部学術大会松江, 2004年11月.
173.	日比野有紀, 藤原崇, 小林進一, 木原勝, 坂本久美子, 山内あい子, 中馬寛 : 薬物の胎盤通過性と母乳移行性のQSAR解析-ClinicalQSAR(2), 第32回構造活性相関シンポジウム, 2004年11月.
174.	糸川大祐, 村上良真, 山内あい子, 中馬寛 : CYP2Bおよび3Aとアゾール系化合物との結合相互作用の解析, 第32回構造活性相関シンポジウム, 2004年11月.
175.	岡崎真由美, 杉理江, 森岡雄二朗, 上田信彦, 木原勝, 山内あい子 : 急速静脈内投与後のセフェム系抗生物質のCSF移行性評価, 第14回日本医療薬学会年会, 2004年10月.
176.	日比野有紀, 藤原崇, 小林進一, 坂本久美子, 木原勝, 山内あい子, 中馬寛 : 薬物の胎盤通過性に関する情報化学的解析, CBI学会 2004年大会, 2004年7月.
177.	山内あい子 : 医薬品安全性情報コミュニティの構築にむけて, JST・RISTEXシンポジウム医薬品安全性情報の循環する社会システムの構築-新しい薬学，新しい時代の薬剤師養成を目指して-, 2004年6月.
178.	山内あい子 : 医薬品安全性情報コミュニティの構築にむけて, 第1回「社会システム/社会技術論」領域シンポジウム, 2004年5月.
179.	藤原崇, 日比野有紀, 木原勝, 山内あい子, 中馬寛 : QSAR手法を用いた薬物のヒト母乳移行性予測, 日本薬学会第124年会, 2004年3月.
180.	糸川大祐, 村上良真, 山内あい子, 中馬寛 : チトクロームP450とアゾール系抗真菌薬との結合相互作用の解析, 日本薬学会第124年会, 2004年3月.
181.	生田賢治, 三木智重子, 山内あい子, 木原勝, 李英培, 西村益浩, 上田信彦, 内藤真策 : ヒト非小細胞肺癌細胞の抗癌剤耐性機構におけるSTATファミリータンパクの関与, 日本薬学会第124年会, 2004年3月.
182.	岡崎真由美, 佐藤栄梨, 森岡雄二朗, 上田信彦, 木原勝, 山内あい子 : ラットを用いたセフェム系抗生物質のCSF動態に関する検討, 日本薬学会第124年会, 2004年3月.
183.	生田雅子, 石澤啓介, 水口和生, 土屋浩一郎, 山内あい子, 木原勝 : 徳島大学病院におけるTPN処方設計支援ソフトの使用評価と改良, 日本薬学会第124年会, 2004年3月.
184.	山内あい子, 中馬寛 : これからの医薬品情報学:医薬情報コミュニティの構築とClinical-QSARの試み, 日本薬学会第124年会(大阪), 2004年3月.
185.	原田恵, 福井伸也, 坂本充司, 山内あい子, 木原勝 : 1 6B 14 -30 ジベンツアゾシン誘導体のα 1 -アドレナリン遮断作用の検討, 第42回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2003年11月.
186.	岡崎真由美, 佐藤栄梨, 木原勝, 山内あい子, 上田信彦, 森岡雄二朗 : 1 6A 14 -40 実験的髄膜炎モデルラットにおけるセフェム系抗生物質のC SF動態, 第42回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2003年11月.
187.	藤原崇, 日比野有紀, 木原勝, 山内あい子, 中馬寛 : 薬物の母乳移行性の定量的構造活性相関解析ーClinical QSARの試みー, 第31回構造活性相関シンポジウム, 2003年11月.
188.	大久保美佐緒, 河野美代, 東満美, 寺岡和彦, 芳地一, 水口和生, 田村祥祐, 仁木稔, 元木宏, 玉田正夫, 山内あい子, 滝口祥令, 木原勝, 原谷明 : 薬学部学生の薬局実務実習についての意識調査∼薬局薬剤師および学生の立場から∼, 第36回日本薬剤師会学術大会, 2003年10月.
189.	生田賢治, 山内あい子, 木原勝 : 抗癌剤耐性ヒト非小細胞肺癌細胞におけるcisplatinによるアポトーシス誘導機構, 第13回日本医療薬学会年会, 2003年9月.
190.	藤原崇, 日比野有紀, 木原勝, 山内あい子, 中馬寛 : 薬物の母乳移行性に関する解析と予測(2)-親水性化合物を含めた解析, CBI学会, 2003年9月.
191.	生田賢治, 竹村佳津, 山内あい子, 木原勝 : ヒト非小細胞肺癌細胞における抗癌剤感受性とアポトーシスとの関連, 日本薬学会第123年会, 2003年3月.
192.	中村佳世, 山内あい子, 木原勝 : ハロゲン化炭化水素による腎細胞毒性に対するN-acetylcysteine の保護作用に関する検討, 日本薬学会第123年会, 2003年3月.
193.	福井伸也, 川高浩, 山内あい子, 木原勝 : 新規ジベンツオキサゾニン誘導体の合成, 日本薬学会第123年会, 2003年3月.
194.	山内あい子 : 抗癌剤治療と薬物·食物相互作用, 鳥取大学医学部肺癌学術講演会, 2002年12月.
195.	佐藤栄梨, 岡崎真由美, 坂部成也, 山内あい子, 木原勝, 上田信彦, 森岡雄二朗 : H.influenzaeによる実験的髄膜炎モデルラットの作成, 第41回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2002年11月.
196.	竹村佳津, 生田賢治, 山内あい子, 木原勝, 清水英治 : ヒト非小細胞肺癌細胞におけるシスプラチン耐性とアポトーシス, 第41回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2002年11月.
197.	生田雅子, 梁木美幸, 山内あい子, 木原勝 : 4-フェニルキノリン誘導体および関連化合物のノルエピネフリン増強作用の検討, 第41回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2002年11月.
198.	生田賢治, 竹村佳津, 山内あい子, 木原勝 : ヒト非小細胞肺癌細胞の抗癌剤感受性と多剤排出トランスポーターの発現, 第12回日本医療薬学会年会, 2002年10月.
199.	山内あい子, 藤原崇, 木原勝, 中馬寛 : 薬物催奇形性試用データベースの紹介, CBI学会第3回大会, 2002年9月.
200.	川崎尚美, 山内あい子, 木原勝, 細野恭平, 藤井正美 : 食品品目別,日本人の1人1日平均喫食量の試算, 第8回日本食品化学学会総会·学術大会, 2002年6月.
201.	山内あい子 : 薬物催奇形性データベース構築の試み, 第29回日本トキシコロジー学会学術年会, 2002年6月.
202.	折井孝男, 山内あい子 : 医療現場と薬学部との連携, 日本薬学会第122年会, 2002年3月.
203.	竹村佳津, 生田賢治, 木原勝, 清水英治, 山内あい子 : ヒト非小細胞肺癌細胞におけるシスプラチン取り込みと多剤排出トランスポーターの発現, 日本薬学会第122年会, 2002年3月.
204.	生田雅子, 梁木美幸, 松下陽子, 山内あい子, 木原勝 : 4-ヒドロキシ-4-フェニルキノリン誘導体の合成と薬理活性の検討, 日本薬学会第122年会, 2002年3月.
205.	川高浩, 山内あい子, 木原勝 : 薬理活性を有する新規ジベンツオキサゾニン誘導体の合成, 日本薬学会第122年会, 2002年3月.
206.	折井孝男, 山内あい子 : 臨床現場が求める情報と薬理学情報の接点を求めて, 第75回日本薬理学会年会, 2002年3月.
207.	中馬寛, 山内あい子 : 薬物催奇形性に関する双方向性成長型情報コミュニティの構築, CBI学会講演会, 2002年2月.
208.	山内あい子 : 薬物催奇形性に関する成長型情報コミュニティの構築, 中小企業総合事業団研究開発交流促進事業平成13年度研究開発交流会, 2002年1月.
209.	海東千明, 山内あい子, 木原勝, 丸山佐起子 : 乳がん細胞増殖抑制作用を有する3-ベンツアゼピン誘導体の合成, 第40回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2001年11月.
210.	新藤雅之, 坂部成也, 山内あい子, 木原勝, 森岡雄二朗, 内藤真策 : ラット脳灌流モデルを用いたセフェム系抗生物質のCSF移行性評価, 第40回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2001年11月.
211.	川崎尚美, 山内あい子, 木原勝, 藤井正美 : 植物性食品における品目別,日本人の1人1日平均喫食量の試算, 第40回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2001年11月.
212.	生田賢治, 竹村佳津, 山内あい子, 木原勝, 清水英治 : ヒト非小細胞肺癌細胞の抗癌剤感受性とシスプラチン核内取り込み量の相関, 第40回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2001年11月.
213.	石井真吾, 山内あい子, 木原勝, 中馬寛, 寺田弘 : 薬物催奇形性試用データベースシステムの構築, 第24回情報化学討論会, 2001年11月.
214.	山内あい子, 石井真吾, 木原勝, 中馬寛, 寺田弘 : 成長型薬物催奇形性情報コミュニティの構築, 第24回情報化学討論会, 2001年11月.
215.	山内あい子 : 医薬品催奇形性データベースの提案, JAPIC「医薬品催奇形性情報に関するシンポジウム」, 2001年10月.
216.	山内あい子 : 薬品の毒性(催奇形性)情報の共有化, 日本ベーリンガーインゲルハイム(株) 川西医薬研究所講演会, 2001年8月.
217.	山内あい子 : 薬物催奇形性に関する双方向性成長型情報コミュニティの構築, JAPIC, 2001年7月.
218.	山内あい子, 中馬寛 : 薬物催奇形性に関する成長型情報コミュニティの構築, 第10回ヒューマンサイエンス総合研究セミナー「医薬品開発における毒性への新しいアプローチ」-計算毒性学·マイクロアレイ·上市後の副作用,相互作用の把握-, 2001年7月.
219.	山内あい子, 中馬寛 : 薬物催奇形性に関する双方向性成長型情報コミュニティの構築, JAPIC部長会議, 2001年6月.
220.	川崎尚美, 山内あい子, 木原勝, 細野恭平, 藤井正美 : 食品品目別,日本人の1人1日平均喫食量の試算, 第7回日本食品化学学会総会·学術大会, 2001年6月.
221.	新藤雅之, 森岡雄二朗, 内藤真策, 山内あい子, 木原勝 : ラット側脳室-大槽灌流モデルを用いた抗生物質のCSF移行性評価, 日本薬学会第121年会, 2001年3月.
222.	鎌田名月, 本山幸子, 上田信彦, 内藤真策, 山内あい子, 木原勝 : 尿細管上皮細胞におけるN-アセチル-L-システイン輸送担体に関する検討, 日本薬学会第121年会, 2001年3月.
223.	村上涼香, 坂本充司, 前田育, 山内あい子, 木原勝 : エタノールアミン骨格を有するテトラリン誘導体の合成, 日本薬学会第121年会, 2001年3月.
224.	板東理恵, 石井美里, 小野田陽子, 李英培, 山内あい子, 木原勝 : ハロゲン化炭化水素による腎尿細管細胞のアポトーシスとミトコンドリア毒性, 日本薬学会第121年会, 2001年3月.
225.	山内あい子 : POSに基づく薬剤服用歴管理指導の記録 -SOAP演習-, 高松市薬剤師会第36回学術研修会, 2000年11月.
226.	松下陽子, 坂本充司, 石井一也, 生田雅子, 山内あい子, 木原勝 : 薬理活性を有する4-Hydroxy-4-phenyl-1,2,3,4,-tetrahydroquinoline誘導体の合成, 第39回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2000年10月.
227.	石井真吾, 武本有子, 山内あい子, 木原勝 : 双方向性薬物催奇形性データベース·システムの構築, 第39回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 2000年10月.
228.	竹内隆文, 蔵本和彦, 山内あい子, 木原勝 : 多剤併用の肝·腎機能に及ぼす影響 -臨床検査値からの評価-, 第10会日本病院薬学会年会, 2000年10月.
229.	石井真吾, 山内あい子, 木原勝, 中馬寛, 寺田弘 : 双方向性薬物催寄性データベース·システム構築の試み, 第23回情報化学討論会, 2000年10月.
230.	山内あい子 : 問題志向システム(POS)によるファーマシューティカルケアの記録 -POSとSOAPの基礎-, 高松市薬剤師会第35回学術研修会, 2000年9月.
231.	山内あい子 : POSに基づくファーマシューティカルケアの記録-基礎と演習-, 日本女性薬剤師会四国ブロック研修会, 2000年6月.
232.	上田信彦, 山内あい子, 木原勝, 浜村政夫, 内藤真策 : N-Acetyl-L-Cysteineの体内分布と脱アセチル化酵素の臓器分布, 日本薬学会第120年会, 2000年3月.
233.	海東千明, 山本修平, 山内あい子, 木原勝 : 乳ガン細胞増殖抑制作用を有する3-ベンツアゼピン誘導体の合成, 日本薬学会第120年会, 2000年3月.
234.	海東千明, 山本修平, 山内あい子, 木原勝 : α-アドレナリン遮断作用を有する工学活性名ジベンツアゾシン誘導体の合成, 日本薬学会第120年会, 2000年3月.
235.	佐々木健一, 生田賢治, 山内あい子, 木原勝, 清水英治 : 非詳細某肺癌培養細胞の抗癌剤感受性と多剤耐性関連蛋白質の発現, 日本薬学会第120年会, 2000年3月.
236.	山内あい子 : 医薬分業と薬剤師, 徳島県薬剤師会研修会, 2000年3月.
237.	山内あい子 : くすりと飲食物の相互作用, 山口県健康福祉センター栄養士研修会·市町村栄養士研修会, 1999年11月.
238.	板東理恵, 高田友美, 山内あい子, 木原勝, 李英培 : 近位および遠位尿細管細胞におけるハロゲン化炭化水素による毒性発現の比較, 第38回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 1999年10月.
239.	山下英里, 鎌田名月, 山内あい子, 木原勝, 上田信彦, 内藤真策 : 腎尿細管上皮細胞におけるN-アセチル-L-システインの輸送機構, 第38回日本薬学会·日本病院薬剤師会中国四国支部学術大会, 1999年10月.
240.	山内あい子 : 問題解決能力を備えた薬剤師の育成-4年次卒前長期病院実習の現時点での評価, 第9回日本病院薬学会年会, 1999年9月.
241.	山内あい子 : POSと薬剤師, 徳島県薬剤師会研修会, 1999年6月.
242.	北本亜紀, 板東理恵, 山内あい子, 木原勝, 李英培 : 腎上皮細胞培養系におけるハロゲン化炭化水素による細胞障害とアポトーシスの発現, 日本薬学会第119年会, 1999年3月.
243.	佐々木健一, 中野志保, 武市佳己, 篠原ルミ, 山内あい子, 木原勝, 清水英治, 曾根三郎 : 非小細胞肺癌患者における化学療法の臨床成績と患者由来肺癌細胞培養系における抗癌剤感受性の相関について, 日本薬学会第119年会, 1999年3月.
244.	花房小百合, 山下英里, 山内あい子, 木原勝, 上田信彦, 内藤真策 : 哺乳類におけるN-アセチル-L-システイン脱アセチル化酵素の種差と臓器分布, 日本薬学会第119年会, 1999年3月.
245.	山内あい子, 黒木保久 : 薬学領域における情報インフラの構築とその利用, 日本薬学会第119年会シンポジウム6, 1999年3月.
246.	福山充俊, 嵩原裕夫, 石橋広樹, 田代征記, 滝口祥令, 岩野淳子, 山内あい子 : 小児における血中セレン濃度の検討-第1報新生児について-, 第15回日本静脈経腸栄養学会, 1999年2月.
247.	山内あい子 : くすりと飲食物の相互作用, 山口県立大学生活科学部栄養学科特別講演, 1999年1月.
248.	北本亜紀, 板東理恵, 山内あい子, 木原勝, 李英培 : ハロゲン化炭化水素による腎上皮細胞毒性の発現とアポトーシスの誘導, 徳島生物学会第102回総会, 1998年12月.
249.	山内あい子 : 薬物と腎障害-薬物性腎障害, 徳島臨床薬学懇話会特別講演, 1998年11月.
250.	北本亜紀, 板東理恵, 山内あい子, 木原勝, 李英培 : 培養腎上皮細胞におけるハロゲン化炭化水素システイン抱合体による細胞毒性発現とアポトーシス, 第37回日本薬学会·日本病院薬剤師会学術大会中国四国支部大会, 1998年10月.
251.	花房小百合, 山下英里, 山内あい子, 木原勝, 原田大輔, 上田信彦, 内藤真策 : N-アセチル-L-システイン脱アセチル化酵素の臓器分布と種, 第37回日本薬学会·日本病院薬剤師会学術大会中国四国支部大会, 1998年10月.
252.	喜田久美子, 松下陽子, 岩井靖賢, 山内あい子, 木原勝 : 有機金属試薬を用いる新規二量化反応の開発, 第37回日本薬学会·日本病院薬剤師会学術大会中国四国支部大会, 1998年10月.
253.	山内あい子 : 腎疾患とその薬物治療, 徳島臨床薬学懇話会特別講演, 1998年7月.
254.	井沢伸平, 福多由佳, 岩井靖賢, 山内あい子, 木原勝, 貴田寛, 久山哲廣 : ノルアドレナリン増強作用を有するテトラヒドロイソキノリン誘導体の合成と構造活性相関, 日本薬学会第118年会, 1998年3月.
255.	山内あい子, 滝口祥令, 横田雅之, 木原勝, 久次米俊秀, 寺岡和彦, 水口和生, 高杉益充 : 徳島大学大学院薬学研究科医療薬学専攻における初年度臨床薬学実習の評価, 日本薬学会第118年会, 1998年3月.
256.	北本亜紀, 山内あい子, 木原勝, 見田秋与志, 鎌田信彦, 李英培 : 腎上皮細胞におけるハロゲン化炭化水素システイン抱合体による細胞毒性と核のDNA断片化, 日本薬学会第118年会, 1998年3月.
257.	花房小百合, 山下英里, 山内あい子, 木原勝, 上田信彦, 内藤真策 : N-アセチル-L-システインの体内動態と代謝, 日本薬学会第118年会, 1998年3月.
258.	山内あい子 : くすりの相互作用と安全性, 第3回徳島大学薬学部卒後教育公開講座, 1997年12月.
259.	福島真理, 坂本充司, 山内あい子, 木原勝 : 乳がん細胞増殖抑制作用を有する3,4-ジフェニルイソキノリン誘導体の合成, 第36回日本薬学会·日本病院薬剤師会学術大会中国四国支部大会, 1997年11月.
260.	合田真規, 山内あい子, 木原勝, 土屋浩一郎, 水口和生 : 徳島大·医·病院におけるIVH処方設計支援ソフトを使用してみて, 第36回日本薬学会·日本病院薬剤師会学術大会中国四国支部大会, 1997年11月.
261.	山内あい子 : 薬物相互作用の基礎知識, 平成9年度日本女子薬剤師会四国ブロック総会, 1997年9月.
262.	横田雅之, 木原勝, 滝口祥令, 山内あい子 : 学部および大学院における医療薬学教育の実践-実習カリキュラムと学生対象アンケート調査の結果-, 日本薬学会第117年会, 1997年3月.
263.	李英培, 北本亜紀, 松永直哉, 山内あい子, 木原勝 : ハロゲン化炭化水素システイン抱合体による腎上皮細胞毒性発現時のDNA断片化と核構造変化, 日本薬学会第117年会, 1997年3月.
264.	山内あい子, 滝口祥令, 横田雅之, 木原勝, 寺岡和彦, 水口和生, 高杉益充 : 薬学部における1ヶ月必修の病院実習を実施して-実習カリキュラムと学生対象アンケート調査の結果-, 日本薬学会第117年会, 1997年3月.
265.	丸山茂樹, 池内元樹, 池内美由紀, 山内あい子, 木原勝 : 生物活性を有する3-ベンツアゼピン誘導体の合成, 日本薬学会第117年会, 1997年3月.
266.	木原勝, 池内元樹, 山内あい子, 糠塚守, 松本宏, 東岡俊之 : 乳がん細胞増殖抑制作用を有する3,4-diphenyl-1,2-dihydroisoquinoline誘導体および関連化合物の合成と構造活性相関, 第5回医薬化学部会年会, 1996年11月.
267.	山内あい子, 木原勝, 昆陽朋子, 宮西紀子, 山崎裕康 : ラット腎ハロゲン化炭化水素-システイン抱合体β;-リアーゼの性質, 第35回日本薬学会·日本病院薬剤師会学術大会中国四国支部大会, 1996年10月.
268.	山内あい子 : 薬学教育改善の現状と方向, 徳島臨床薬学懇話会特別講演, 1996年9月.
269.	山内あい子 : 薬物相互作用の考え方, 兵庫県薬剤師生涯教育研修会, 1995年10月.

その他・研究会:

1.	山内あい子 : 大学における男女共同参画を考えるなぜ，女性が大学に必要なのか, 愛媛大学女性未来育成センター公開シンポジウム2016, 2016年12月.
2.	山内あい子 : くらしの医薬品情報, 徳島県消費者大学校公開講座, 2016年7月.
3.	山内あい子 : 女性研究者研究活動支援事業による成果の継続と発展をめざして, 第5回中国四国男女共同参画シンポジウム, 2013年11月.
4.	重永章, 山本純, 前田奈美, 佐藤陽一, 山内あい子, 大髙章 : 標的タンパク質の精製およびラベル化を可能とするトレーサブルリンカーの開発, 新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第2回若手研究者ワークショップ, 2012年10月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

男性不妊症における新規原因遺伝子の同定に向けた２方向からのアプローチ (研究課題/領域番号: 26462461 )
データマイニング技術でヒトにおける医薬品の安全性を予測し得るか？ (研究課題/領域番号: 23590185 )
医薬品安全性情報コミュニティ・知的共有基盤の活用と薬学部情報薬局教育研究への応用 (研究課題/領域番号: 17590126 )
医薬情報コミュニティ中核としての薬学部情報薬局の立ち上げと教育研究への活用 (研究課題/領域番号: 15659039 )
研究者番号（30122253）による検索

名誉教授 : 山内 あい子

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

名誉教授 : 山内あい子