Tokushima University / Educator and Researcher Directory --- Morine, Yuji

Field of Study

○	Medicine

Subject of Study

○

Book / Paper

Book:

1.	Yuji Morine, Mitsuo Shimada and Toru Utsunomiya : IV胆道発癌 1.全国集計からみた発癌頻度と特徴., 医学図書出版, Nov. 2011. (Keyword) 和文論文
2.	Mitsuo Shimada, Toru Utsunomiya and Yuji Morine : V治療 2.全国集計からみた外科治療, 医学図書出版, Nov. 2011. (Keyword) 和文論文
3.	Yuji Morine, Mitsuo Shimada and Toru Utsunomiya : 臓器部位別の治療戦略肝がんー手術とインターベンション, PEIT, RFA, TAEなどー., 2010. (Keyword) 和文論文
4.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 岩橋衆一 and 斎藤裕 : 腹腔鏡下肝切除術 4．術中・術後のトラブルと回避法ガス塞栓, NANZANDO Co.,Ltd., 2010. (Keyword) 和文論文

Academic Paper (Judged Full Paper):

1.	Chie Takasu, Shuhai Chen, Luping Gao, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : Role of Nrf2 signaling in development of hepatocyte-like cells, The Journal of Medical Investigation : JMI, Vol.70, No.3,4, 343-349, 2023. (Summary) Generation of hepatocytes from human adipose-derived mesenchymal stem cells (hADSCs) could be a promising alternative source of human hepatocytes. However, mechanisms to differentiate hepatocytes from hADSCs are not fully elucidated. We have previously demonstrated that our three-step differentiation protocol with glycogen synthase kinase (GSK) 3 inhibitor was effective to improve hepatocyte functions. In this study, we investigated the activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) on hADSCs undergoing differentiation to HLC (hepatocyte-like cells). Our three-step differentiation protocol was applied for 21 days (Step 1:day 1-6, Step2:day 6-11, Step3:day 11-21). Our results show that significant nuclear translocation of Nrf2 occurred from day 11 until the end of HLC differentiation. Nuclear translocation of Nrf2 and CYP3A4 activity in the GSK3 inhibitor-treated group was obviously higher than that in Activin A-treated groups at day 11. The maturation of HLCs was delayed in Nrf2-siRNA group compared to control group. Furthermore, CYP3A4 activity in Nrf2-siRNA group was decreased at the almost same level in Activin A-treated group. Nrf2 translocation might enhance the function of HLC and be a target for developing highly functional HLC. J. Med. Invest. 70 : 343-349, August, 2023. (Keyword) Humans / NF-E2-Related Factor 2 / Glycogen Synthase Kinase 3 / Cytochrome P-450 CYP3A / Hepatocytes / Cell Differentiation / RNA, Small Interfering (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.343 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940517 ● Search Scopus @ Elsevier (PMID): 37940517 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.343 (DOI: 10.2152/jmi.70.343, PubMed: 37940517)
2.	Shoko Yamashita, Chie Takasu, Yuji Morine, Hiroki Ishibashi, Tetsuya Ikemoto, Hiroki Mori, Shin-ichiro Yamada, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.30, No.4, 462-472, 2023. (Summary) Activated fibroblasts and M2 macrophages in the GB lamina propria may be associated with biliary carcinogenesis of PBM, possibly through inflammasome activation. (Keyword) Humans / Inflammasomes / Bile Ducts / Caspase 1 / NLR Family, Pyrin Domain-Containing 3 Protein / Pancreaticobiliary Maljunction / Pancreatic Ducts / Biliary Tract Neoplasms / Gallbladder Neoplasms / Cholecystitis / Carcinogenesis (Tokushima University Institutional Repository) ● Metadata: 119056 (Link to Publication Site) ● Publication site (DOI): 10.1002/jhbp.1253 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36259178 ● Search Scopus @ Elsevier (PMID): 36259178 ● Search Scopus @ Elsevier (DOI): 10.1002/jhbp.1253 (Tokushima University Institutional Repository: 119056, DOI: 10.1002/jhbp.1253, PubMed: 36259178)
3.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Mayuko Shimizu, Koichi Tsuneyama, Mitsue Nishiyama, Shiori Ishizawa and Mitsuo Shimada : Effect of daikenchuto (TU-100) on carcinogenesis in non-alcoholic steatohepatitis., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 66-73, 2023. (Summary) TU-100 regulates the intestinal microbiome and may suppress subsequent hepatocarcinogenesis in the NASH model. J. Med. Invest. 70 : 66-73, February, 2023. (Keyword) Mice / Animals / Non-alcoholic Fatty Liver Disease / Carcinoma, Hepatocellular / Liver Neoplasms / Liver / Carcinogenesis (Tokushima University Institutional Repository) ● Metadata: 118309 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.66 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164745 ● Search Scopus @ Elsevier (PMID): 37164745 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.66 (Tokushima University Institutional Repository: 118309, DOI: 10.2152/jmi.70.66, PubMed: 37164745)
4.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki, Mayuko Shimizu, Koichi Tsuneyama and Mitsuo Shimada : Inhibitory effect of non-alcoholic steatohepatitis on colon cancer liver metastasis., EJSO - European Journal of Surgical Oncology, Vol.49, No.2, 410-415, 2023. (Summary) The WD-fed NASH mouse model showed an inhibitory effect on CLM. Suppressed interleukin-6/signal transducer and activator of transcription 3 signaling and serum amyloid A/matrix metalloproteinase 9 expression may affect this phenomenon. (Keyword) Male / Mice / Animals / Non-alcoholic Fatty Liver Disease / Mice, Inbred C57BL / Liver / Liver Neoplasms / Disease Models, Animal / Colonic Neoplasms / RNA, Messenger (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ejso.2022.11.002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36371329 ● Search Scopus @ Elsevier (PMID): 36371329 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejso.2022.11.002 (DOI: 10.1016/j.ejso.2022.11.002, PubMed: 36371329)
5.	Yu Saitou, Mitsuo Shimada, Yuji Morine, Shin-ichiro Yamada and Maki Sugimoto : Essential updates 2020/2021: Current topics of simulation and navigation in hepatectomy., Annals of Gastroenterological Surgery, Vol.6, No.2, 190-196, 2021. (Summary) With the development of three-dimensional (3D) simulation software, preoperative simulation technology is almost completely established. The remaining issue is how to recognize anatomy three-dimensionally. Extended reality is a newly developed technology with several merits for surgical application: no requirement for a sterilized display monitor, better spatial awareness, and the ability to share 3D images among all surgeons. Various technology or devices for intraoperative navigation have also been developed to support the safety and certainty of liver surgery. Consensus recommendations regarding indocyanine green fluorescence were determined in 2021. Extended reality has also been applied to intraoperative navigation, and artificial intelligence (AI) is one of the topics of real-time navigation. AI might overcome the problem of liver deformity with automatic registration. Including the issues described above, this article focuses on recent advances in simulation and navigation in liver surgery from 2020 to 2021. (Tokushima University Institutional Repository) ● Metadata: 117276 (Link to Publication Site) ● Publication site (DOI): 10.1002/ags3.12542 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35261944 ● Search Scopus @ Elsevier (PMID): 35261944 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12542 (Tokushima University Institutional Repository: 117276, DOI: 10.1002/ags3.12542, PubMed: 35261944)
6.	Katsuki Miyazaki, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Takeshi Oya, Tetsuya Ikemoto, Satoru Imura, Haun Hu, Hisayoshi Morioka, Koichi Tsuneyama and Mitsuo Shimada : Stromal tumor-infiltrating lymphocytes level as a prognostic factor for resected intrahepatic cholangiocarcinoma and its prediction by apparent diffusion coefficient., International Journal of Clinical Oncology, Vol.26, No.12, 2265-2274, 2021. (Summary) Tumor-infiltrating lymphocytes (TILs) are a prognostic factor or an indicator of chemotherapy response for various malignancies. The aim of this study was to investigate the prognostic impact of TILs in resected intrahepatic cholangiocarcinoma (IHCC). We also investigated the usefulness of the apparent diffusion coefficient (ADC) in diffusion-weighted magnetic resonance imaging (DW-MRI) to predict TILs. We enrolled 23 patients with IHCC who underwent initial hepatic resection in Tokushima University Hospital from 2006 to 2017. We evaluated stromal TILs in the tumor marginal area and central area in surgical specimens. Patients were divided into low vs high stromal TILs groups. We analyzed the patients' clinicopathological factors, including prognosis, according to the degree of stromal TILs. We also analyzed the correlation between stromal TILs and the minimum ADC value. Stromal TILs in the marginal area reflected overall survival more accurately than that in the central area. Additionally, marginal low TILs was significantly associated with lymph node metastasis and portal vein invasion. Both overall- and disease-free survival rates in the marginal low TILs group were significantly worse than those in the marginal high TILs group (P < 0.05). In the multivariate analysis, marginal low TILs were an independent prognostic factor for both overall- and disease-free survival (P < 0.05), and marginal low TILs were significantly associated with lower minimum ADC values (P < 0.02). Stromal TILs, especially in the marginal area, might demonstrate prognostic impact in patients with IHCC. Moreover, the ADC values from MRI may predict TILs in IHCC tumor tissue. (Keyword) Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Diffusion Magnetic Resonance Imaging / Humans / Lymphocytes, Tumor-Infiltrating / Prognosis (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-021-02026-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34596803 ● Search Scopus @ Elsevier (PMID): 34596803 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-021-02026-3 (DOI: 10.1007/s10147-021-02026-3, PubMed: 34596803)
7.	Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Katsuki Miyazaki, Shin-ichiro Yamada, Satoru Imura, Masato Miyake, Yuji Morine, Seiichi Oyadomari and Mitsuo Shimada : Effective three-dimensional culture of hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.28, No.9, 705-715, 2021. (Summary) The aim of this study was to clarify the effectiveness of a new three-dimensional (3D) culture system for hepatocyte-like cells (HLCs) generated from human adipose-derived mesenchymal stem cells (ADSCs). Human ADSCs (2 × 10 ) with or without 0.1 mg/mL human recombinant peptide μ-piece per well were seeded in a 96-well U-bottom plate and then our three-step differentiation protocol was applied for 21 days. At each step, cell morphology and gene expression were investigated. Mature hepatocyte functions were evaluated after HLC differentiation. These parameters were compared between 2D- and 3D-cultured HLCs, and, DNA microarray analysis was also performed. Finally, HLCs were transplanted in to CCl induced acute liver failure model mice. Two-dimensional-cultured HLCs at day 21 did not have a spindle shape and had formed spheroids after day 6, which gradually increased in size for 3D-cultured HLCs. Definitive endoderm, hepatoblast, and hepatocyte genes showed significantly higher expression in the 3D culture group. Three-dimensional-cultured HLCs also had higher albumin expression, CYP3A4 activity, urea synthesis, and ammonium metabolism, and much higher expression of ion transporter, blood coagulation, and cell communication genes. HLC transplantation improved serum liver function, especially in T-Bil levels, and engrafted into immunodeficient mice with HLA class I positive staining. Our new 3D culture protocol is effective to improve hepatocyte functions. Our HLCs might be promising for clinical cell transplantation to treat metabolic disease. (Link to Publication Site) ● Publication site (DOI): 10.1002/jhbp.1024 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34318615 ● Search Scopus @ Elsevier (PMID): 34318615 ● Search Scopus @ Elsevier (DOI): 10.1002/jhbp.1024 (DOI: 10.1002/jhbp.1024, PubMed: 34318615)
8.	Yuji Morine, Hiroki Ishibashi and Mitsuo Shimada : 【胆管損傷と(医原性)術後胆管狭窄:回避とリカバリー法】先天性胆道拡張症手術における胆道再建と術後胆管狭窄へのリカバリーショット, Journal of Biliary Tract & Pancreas, Vol.42, No.7, 631-637, 2021.
9.	Shoko Yamashita, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Shinichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Katsuki Miyazaki, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2., World Journal of Surgical Oncology, Vol.19, No.1, 142, 2021. (Summary) This method could be used to classify IHCC into peripheral and perihilar type by embryological expression patterns of SSTR2 and Bcl2. (Keyword) Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Humans / Prognosis / Proto-Oncogene Proteins c-bcl-2 / Receptors, Somatostatin (Tokushima University Institutional Repository) ● Metadata: 116986 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12957-021-02216-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33962620 ● Search Scopus @ Elsevier (PMID): 33962620 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02216-3 (Tokushima University Institutional Repository: 116986, DOI: 10.1186/s12957-021-02216-3, PubMed: 33962620)
10.	Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : Value of the fibrinogen-platelet ratio in patients with resectable pancreatic cancer., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 342-346, 2021. (Summary) Background : Several prognostic factors were reported in pancreatic cancer. The fibrinogen-platelet ratio (FPR) was reported as a prognostic factor of resectable gastric cancer. In this report, the FPR was evaluated in patients with resectable pancreatic cancer. Methods : Between 2004 and 2019, 163 patients with curative resection for pancreatic cancer were enrolled. Cases of non-curative resection were excluded. The FPR was calculated using the preoperative plasma fibrinogen and the platelet counts and the cut-off value was determined by receiver operating characteristic (ROC) curve analysis. The patients were divided into high and low FPR groups according to this cut-off value. Results : The cut-off value of FPR was 25.2. Among age, sex, body mass index (BMI), and surgical factors including surgery type, volume of blood loss and surgery time, there was no significant difference between the two groups. Patients in the low FPR group had significantly better overall survival (OS) and relapse-free survival (RFS) compared with the high FPR group (P < 0.05). On multivariate analysis, a high FPR, CA19-9 > 300 U /l, and receipt of adjuvant chemotherapy were independent risk factors for OS and DFS. Conclusions : The FPR might be a prognostic factor for patients with resectable pancreatic cancer. J. Med. Invest. 68 : 342-346, August, 2021. (Keyword) Biomarkers, Tumor / Fibrinogen / Humans / Neoplasm Recurrence, Local / Pancreatic Neoplasms / Prognosis / Retrospective Studies (Tokushima University Institutional Repository) ● Metadata: 116535 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.342 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759156 ● Search Scopus @ Elsevier (PMID): 34759156 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.342 (Tokushima University Institutional Repository: 116535, DOI: 10.2152/jmi.68.342, PubMed: 34759156)
11.	Hiroki Ishibashi, Mitsuo Shimada and Yuji Morine : 【膵・胆管合流異常と先天性胆道拡張症】疫学, Clinical Gastroenterology, Vol.35, No.4, 355-362, 2020. (Link to Publication Site) ● Publication site (DOI): 10.19020/cg.0000001104 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390285300151312256 ● Search Scopus @ Elsevier (DOI): 10.19020/cg.0000001104 (DOI: 10.19020/cg.0000001104, CiNii: 1390285300151312256)
12.	Shuichi Iwahashi, Feng Rui, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Hepatic Stellate Cells Contribute to the Tumor Malignancy of Hepatocellular Carcinoma Through the IL-6 Pathway., Anticancer Research, Vol.40, No.2, 743-749, 2020. (Summary) The hepatic stellate cells (HSCs) have relationship to cancer progression. The aim of this study is to investigate the effect of HSCs and the role of IL-6/Stat3 pathway on hepatocellular carcinoma (HCC) progression. HCCs were co-cultured with HSCs. The viability and migration ability of cancer cells were detected. Epithelial-mesenchymal transition (EMT) marker (E-cadherin), stem cell marker (CD44) and p-signal transducer and activator of transcription 3 (p-STAT3) of cancer cells were evaluated. Finally, interleukin-6 (IL-6) neutralization was performed. Co-culture of HCCs with HSCs increased cancer cell viability and migration ability. EMT and stemness of cancer cells increased with HSCs. Following IL-6 neutralization, phospho-STAT3 activation, cancer cell viability and migration, as well as EMT, and stemness of cancer cells decreased. HSCs promoted HCC progression through the IL-6/STAT3 pathway. (Keyword) Carcinoma, Hepatocellular / Cell Communication / Cell Line, Tumor / Cell Movement / Cell Survival / Coculture Techniques / Hep G2 Cells / Hepatic Stellate Cells / Humans / Interleukin-6 / Liver Neoplasms / Neoplastic Stem Cells / STAT3 Transcription Factor / Signal Transduction (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.14005 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32014916 ● Search Scopus @ Elsevier (PMID): 32014916 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.14005 (DOI: 10.21873/anticanres.14005, PubMed: 32014916)
13.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Toru Utsunomiya : Effect of epigenetic modulation on cancer sphere., The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 70-74, 2020. (Summary) Background : Cancer stem cell properties are highly relevant to the biology of treatment-resistant cancers. Epigenetic modification regulates gene expressions by chromatin remodeling during malignant transformation. The aim of this study was to elucidate the possible strategy for cancer stem cells focusing on epigenetic modification. Methods : We made cancer sphere from HepG2 cells, and we added Histone deacetylase (HDAC) inhibitor, valproic acid to cancer sphere. And we compared methylation status and the gene expression between normal HepG2 and cancer sphere groups, and between cancer sphere and sphere with HDAC inhibitor treatment groups. Results : Valproic acid (VPA) cancelled this spheroid formation. In comparison between normal HepG2 and cancer sphere, the number of methylation status changes more than 0.1 of beta level was 826 probes, and we could isolate some epithelial-mesenchymal transition (EMT) related genes. And VPA reduced the expressions of EMT related genes in sphere with RT-PCR. On the other hand, in comparison between cancer sphere and sphere with VPA treatment, we detected 29 probe of methylation status change, and VPA reduced the expressions of Bcl-6 in sphere. Conclusions : HDAC inhibitor affected the methylation status of cancer stem cells. Histone-acetylation might overcome treatmet-resistant cancer through the regulation of cancer stem cell. J. Med. Invest. 67 : 70-74, February, 2020. (Keyword) DNA Methylation / Epithelial-Mesenchymal Transition / Hep G2 Cells / Histone Deacetylase Inhibitors / Humans / Neoplasms / Neoplastic Stem Cells / Spheroids, Cellular / Valproic Acid (Tokushima University Institutional Repository) ● Metadata: 114755 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.67.70 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378621 ● Search Scopus @ Elsevier (PMID): 32378621 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.70 (Tokushima University Institutional Repository: 114755, DOI: 10.2152/jmi.67.70, PubMed: 32378621)
14.	Shogo Ohta, Tetsuya Ikemoto, Yuma Wada, Yu Saitou, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells., Scientific Reports, Vol.9, No.1, 18731, 2019. (Summary) The generation of insulin-producing cells (IPCs) from pluripotent stem cells could be a breakthrough treatment for type 1 diabetes. However, development of new techniques is needed to exclude immature cells for clinical application. Dithizone staining is used to evaluate IPCs by detecting zinc. We hypothesised that zinc ion (Zn) dynamics reflect the IPC maturation status. Human adipose-derived stem cells were differentiated into IPCs by our two-step protocol using two-dimensional (2D) or 3D culture. The stimulation indexes of 2D -and 3D-cultured IPCs on day 21 were 1.21 and 3.64 (P < 0.05), respectively. The 3D-cultured IPCs were stained with dithizone during culture, and its intensity calculated by ImageJ reached the peak on day 17 (P < 0.05). Blood glucose levels of streptozotocin-induced diabetic nude mice were normalised (4/4,100%) after transplantation of 96 3D-cultured IPCs. Zn concentration changes in the medium of 3D cultures had a negative value in the early period and a large positive value in the latter period. This study suggests that Zn dynamics based on our observations and staining of zinc transporters have critical roles in the differentiation of IPCs, and that their measurement might be useful to evaluate IPC maturation as a non-destructive method. (Tokushima University Institutional Repository) ● Metadata: 114940 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-019-55172-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31822724 ● Search Scopus @ Elsevier (PMID): 31822724 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-55172-0 (Tokushima University Institutional Repository: 114940, DOI: 10.1038/s41598-019-55172-0, PubMed: 31822724)
15.	Tetsuya Ikemoto, Rui Feng, Shuichi Iwahashi, Shin-ichiro Yamada, Yu Saitou, Yuji Morine, Satoru Imura, Munehide Matsuhisa and Mitsuo Shimada : In vitro and in vivo effects of insulin-producing cells generated by xeno-antigen free 3D culture with RCP piece., Scientific Reports, Vol.9, No.1, 2019. (Summary) To establish widespread cell therapy for type 1 diabetes mellitus, we aimed to develop an effective protocol for generating insulin-producing cells (IPCs) from adipose-derived stem cells (ADSCs). We established a 3D culture using a human recombinant peptide (RCP) petaloid μ-piece with xeno-antigen free reagents. Briefly, we employed our two-step protocol to differentiate ADSCs in 96-well dishes and cultured cells in xeno-antigen free reagents with 0.1 mg/mL RCP μ-piece for 7 days (step 1), followed by addition of histone deacetylase inhibitor for 14 days (step 2). Generated IPCs were strongly stained with dithizone, anti-insulin antibody at day 21, and microstructures resembling insulin secretory granules were detected by electron microscopy. Glucose stimulation index (maximum value, 4.9) and MAFA mRNA expression were significantly higher in 3D cultured cells compared with conventionally cultured cells (P < 0.01 and P < 0.05, respectively). The hyperglycaemic state of streptozotocin-induced diabetic nude mice converted to normoglycaemic state around 14 days after transplantation of 96 IPCs under kidney capsule or intra-mesentery. Histological evaluation revealed that insulin and C-peptide positive structures existed at day 120. Our established xeno-antigen free and RCP petaloid μ-piece 3D culture method for generating IPCs may be suitable for clinical application, due to the proven effectiveness in vitro and in vivo. (Tokushima University Institutional Repository) ● Metadata: 114941 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-019-47257-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31341242 ● Search Scopus @ Elsevier (PMID): 31341242 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-47257-7 (Tokushima University Institutional Repository: 114941, DOI: 10.1038/s41598-019-47257-7, PubMed: 31341242)
16.	Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Photobiomodulation with red light emitting diodes accelerates hepatocytes proliferation through reactive oxygen species / extracellular signal-regulated kinase pathway., Hepatology Research, Vol.48, No.11, 926-936, 2018. (Link to Publication Site) ● Publication site (DOI): 10.1111/hepr.13182 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85050405346 (DOI: 10.1111/hepr.13182, Elsevier: Scopus)
17.	Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction, Cell Communication & Signaling, Vol.16, No.1, 54, 2018. (Summary) The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)-Like 2 (Nrf2) not only modulates the angiogenesis but also plays the anti-inflammatory role through inhibiting pro-inflammatory cytokines expression; however, the role of Nrf2 in the cancer cell and macrophages interaction is not clear. Hepatocellular carcinoma cells (Hep G2 and Huh 7) and pancreatic cancer cells (SUIT2 and Panc-1) were co-cultured with monocytes cells (THP-1) or peripheral blood monocytes derived macrophages, then the phenotype changes of macrophages and epithelial-mesenchymal transition of cancer cells were detected. Also, the role of Nrf2 in cancer cells and macrophages interaction were investigated. In this study, we found that cancer cells could induce an M2-like macrophage characterized by up-regulation of CD163 and Arg1, and down-regulation of IL-1b and IL-6 through Nrf2 activation. Also, Nrf2 activation of macrophages promoted VEGF expression. The Nrf2 activation of macrophages correlated with the reactive oxygen species induced by cancer cells derived lactate. Cancer cells educated macrophages could activate Nrf2 of the cancer cells, in turn, to increase cancer cells epithelial-mesenchymal transition (EMT) through paracrine VEGF. These findings suggested that Nrf2 played the important role in the cancer cells and macrophages interaction. Macrophage Nrf2 activation by cancer cell-derived lactate skews macrophages polarization towards an M2-like phenotype and educated macrophages activate Nrf2 of the cancer cells to promote EMT of cancer cells. This study provides a new understanding of the role of Nrf2 in the cancer cell and TAM interaction and suggests a potential therapeutic target. (Keyword) Cell Communication / Cell Movement / Cell Transformation, Neoplastic / Epithelial-Mesenchymal Transition / Gene Expression Regulation, Neoplastic / Hep G2 Cells / Humans / Lactic Acid / Macrophages / NF-E2-Related Factor 2 / Phenotype / Reactive Oxygen Species / Vascular Endothelial Growth Factor A (Tokushima University Institutional Repository) ● Metadata: 114549 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12964-018-0262-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30180849 ● Summary page in Scopus @ Elsevier: 2-s2.0-85053152003 (Tokushima University Institutional Repository: 114549, DOI: 10.1186/s12964-018-0262-x, PubMed: 30180849, Elsevier: Scopus)
18.	Yu Saitou, Satoru Imura, Tetsuya Ikemoto, Yuji Morine, 杉本真樹 and Mitsuo Shimada : 肝癌手術エキスパートへの道 (特集癌手術エキスパートになるための道), Journal of Clinical Surgery, Vol.73, No.9, 1108-1114, 2018. (Keyword) 和文論文 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845702315677568 (CiNii: 1390845702315677568)
19.	Yu Saitou, Shin-ichiro Yamada, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 胆道再建を含む肝切除術 (ビギナーズ特集手術で臓器が「どうなる?」から術後ケアが見える! わかる! イラスト理解消化器外科の術式・術後ケア), Gastroenterological Surgery Nursing, Vol.23, No.8, 709-714, 2018. (Keyword) 和文論文 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521980703420258944 (CiNii: 1521980703420258944)
20.	Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro., Cancer Science, Vol.109, No.8, 2509-2519, 2018. (Summary) Cancer-associated fibroblasts (CAF), derived from stroma of cancer tissues, interact with cancer cells and play an important role in cancer initiation, growth, and metastasis. Nab-paclitaxel (nab-PTX) is a 130 nm albumin-binding paclitaxel and recommended for many types of cancer chemotherapy. The nab-PTX stromal-disrupting effect during pancreatic cancer treatment has been reported. The aim of the present study was to determine the role of nab-PTX in cancer cells and CAF interaction. Cancer cells (MIA PaCa-2 and Panc-1) were cocultured with CAF or treated with CAF conditioned medium, after which their migration and invasion ability, epithelial-mesenchymal transition (EMT)-related marker expression and C-X-C motif chemokine 10 (CXCL10) expression and secretion were detected. Nab-PTX treatment was carried out during the coculture system or during preparation of CAF conditioned medium. Then cancer cell migration and invasion ability, EMT-related marker expression, CXCL10 expression and secretion, and interleukin-6 (IL-6) expression and secretion by CAF were checked After coculture with CAF, migration and invasion ability of cancer cells increased. CAF also downregulated E-cadherin and upregulated N-cadherin and vimentin expression in cancer cells. During coculture or stimulation with cancer cell-cultured medium, CAF significantly increased IL-6 expression and secretion. However, nab-PTX in the coculture system canceled CAF-induced migration and invasion promotion and EMT-related gene changes. Moreover, nab-PTX increased CXCL10 expression of cancer cells which blocked CAF IL-6 expression and secretion. Nab-PTX treatment could increase CXCL10 expression of cancer cells which blocks CAF cancer cell migration and invasion-promoting effect by inhibiting IL-6 expression. (Keyword) Albumins / Biomarkers, Tumor / Cadherins / Cell Line, Tumor / Cell Movement / Cell Proliferation / Chemokine CXCL10 / Coculture Techniques / Down-Regulation / Epithelial-Mesenchymal Transition / Fibroblasts / Humans / Interleukin-10 / Interleukin-6 / Neoplasm Invasiveness / Paclitaxel / Pancreatic Neoplasms / Up-Regulation / Vimentin (Tokushima University Institutional Repository) ● Metadata: 112899 (Link to Publication Site) ● Publication site (DOI): 10.1111/cas.13694 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29902349 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050858344 (Tokushima University Institutional Repository: 112899, DOI: 10.1111/cas.13694, PubMed: 29902349, Elsevier: Scopus)
21.	Yu Saitou, Shin-ichiro Yamada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi and Mitsuo Shimada : A learning curve for laparoscopic liver resection: an effective training system and standardization of technique., Translational Gastroenterology and Hepatology, Vol.3, 45, 2018. (Summary) The incidence of laparoscopic liver resection (LHx) has been increased in the past decade. There have been some reports about some advantages of LHx, in both short and long-term outcomes after operation. The use of a minor LHx was regarded as a standard surgical practice, and some peri-operative complications hindered worldwide increase of LHx in the Second International Consensus Conference on LHx at Morioka. However, no suggestions were described in terms with how to provide the best teaching and training necessary to shorten the learning curve for inexperienced surgeons using a new surgical technique while continuing to maintain a low rate of morbidity from the very beginning. This study includes a literature review of published research which looked at a learning curve for LHx. As well, it proposes a new step-wise training method for inexperienced surgeons and standardization of a technique for LHx focusing especially on laparoscopic left hepatectomy (LLHx). (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.21037/tgh.2018.07.03 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30148230 ● Summary page in Scopus @ Elsevier: 2-s2.0-85052017722 (DOI: 10.21037/tgh.2018.07.03, PubMed: 30148230, Elsevier: Scopus)
22.	Youichiro Kawashita, Yuji Morine, Yu Saitou, Chie Takasu, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Masato Yoshikawa, Satoru Imura, Toshiyuki Yagi and Mitsuo Shimada : Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas., Journal of Gastroenterology and Hepatology, Vol.33, No.7, 1407-1412, 2018. (Summary) Heat shock factor 1 (HSF1), a master regulator of heat shock response, has been shown to play a multifaceted role in cancer progression. However, the clinical significance and biological effect of HSF1 expression in intrahepatic cholangiocarcinoma (IHCC) remain unknown. Forty-nine patients with IHCC who underwent hepatic resection were enrolled in this study. HSF1 expression in tumor tissue was determined by immunohistochemistry, and patients were divided into two groups, those with high (n = 20) and low (n = 29) HSF1 expression. Clinicopathological factors including prognosis were compared in these two groups. HSF1 expression was significantly higher in tumors than in normal tissue. The overall survival rate was significantly lower in patients with high than low HSF1. Multivariate analysis showed that high HSF1 expression was a factor independently prognostic of patient survival. High HSF1 expression in tumor tissues may be a prognostic biomarker in patients with IHCC. (Keyword) Adult / Aged / Aged, 80 and over / Bile Duct Neoplasms / Cell Line, Tumor / Cholangiocarcinoma / Disease Progression / Female / Gene Expression / Heat Shock Transcription Factors / Humans / Immunohistochemistry / Male / Middle Aged / Multivariate Analysis / Prognosis / Survival Rate / Tumor Microenvironment (Link to Publication Site) ● Publication site (DOI): 10.1111/jgh.14078 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29278438 ● Summary page in Scopus @ Elsevier: 2-s2.0-85043330492 (DOI: 10.1111/jgh.14078, PubMed: 29278438, Elsevier: Scopus)
23.	Tetsuya Ikemoto, Rui Feng, Mitsuo Shimada, Yu Saitou, Shuichi Iwahashi, Yuji Morine and Satoru Imura : A new 2-step acceleration protocol using a histone deacetylase inhibitor to generate insulin-producing cells from adipose-derived mesenchymal stem cells, Pancreas, Vol.47, No.4, 477-481, 2018. (Summary) We aimed to develop a simple protocol for deriving insulin-producing cells (IPCs) from adipose-derived mesenchymal stem cells (ADSCs). We established a 2-step creation method and an acceleration strategy with a histone deacetylase inhibitor that promoted a pro-endocrine pancreatic lineage. We seeded ADSCs in 96-well dishes and cultured in Dulbecco's modified Eagle's medium/F12 medium containing 1% fetal bovine serum, 1% B27 supplement, 1% N2 supplement, 50-ng/mL human activin A, and 10-nM exendin-4 for step 1 of differentiation (7 days). Then 10-mM nicotinamide and 50-ng/mL human hepatocyte growth factor, with or without 1 mM histone deacetylase inhibitor, were added for step 2 of differentiation (14 days). After the 2-step differentiation was complete, cell morphology, immunohistochemistry, messenger RNA expression, and function were investigated. Our new differentiation protocol with the histone deacetylase inhibitor significantly accelerated IPC differentiation compared with the conventional protocol without the histone deacetylase inhibitor (median, 21.6 vs 38.8 days; P < 0.05). It also improved the islet morphology score (P < 0.05) and the glucose stimulation index (3.1). By applying our new and easy 2-step protocol using a histone deacetylase inhibitor, ADSCs may be an effective cell source for differentiation of IPCs. (Keyword) Adipose Tissue / Cell Culture Techniques / Cell Differentiation / Cells, Cultured / Culture Media / Histone Deacetylase Inhibitors / Humans / Insulin / Insulin-Secreting Cells / Mesenchymal Stem Cells / Time Factors (Link to Publication Site) ● Publication site (DOI): 10.1097/MPA.0000000000001017 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29517636 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044238547 (DOI: 10.1097/MPA.0000000000001017, PubMed: 29517636, Elsevier: Scopus)
24.	Satoru Imura, Hiroki Teraoku, Masato Yoshikawa, Daichi Ishikawa, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria., International Journal of Clinical Oncology, Vol.23, No.1, 98-103, 2018. (Summary) Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence and investigate predictive factors of mvi before hepatectomy for HCC classified within the Milan criteria. One hundred fifty-nine patients with hepatocellular carcinoma (HCC) classified within the Milan criteria, who underwent hepatectomy, were enrolled in this study. We investigated the risk factors of recurrence. In addition, we divided them into two groups: mvi-negative group and mvi-positive group, based on pathological findings after surgery. We compared the clinicopathological factors between the two groups and determined the risk factors for mvi. Overall survival rate at 1, 3, and 5 years were 91.6%, 80.5%, and 74.9%, and the recurrence-free survival rate at 1, 3, and 5-years were 72.3%, 51.6%, and 37.2%. Risk factor analysis for tumor recurrence revealed that total bilirubin, albumin, ICGR15, AFP-L3, tumor number, mvi, and tumor stage had a significant predictive value. Multivariate analysis revealed that tumor number and mvi were significant independent risk factors for tumor recurrence. Predictive analysis for risk factors of mvi revealed that multiple tumors and AFP-L3 > 10% were significant independent risk factors for mvi in HCC classified within the Milan criteria. The mvi was one of the independent risk factors for tumor recurrence in HCC classified within the Milan criteria. Multiple tumors and high AFP-L3 value were independent predictive factors for mvi. (Keyword) Aged / Bilirubin / Carcinoma, Hepatocellular / Disease-Free Survival / Female / Hepatectomy / Humans / Liver Neoplasms / Male / Middle Aged / Multivariate Analysis / Neoplasm Recurrence, Local / Retrospective Studies / Risk Factors / Survival Rate (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-017-1189-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28875240 ● Summary page in Scopus @ Elsevier: 2-s2.0-85028981662 (DOI: 10.1007/s10147-017-1189-8, PubMed: 28875240, Elsevier: Scopus)
25.	Toshiaki Yoshimoto, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Daichi Ishikawa, Hiroki Teraoku, Yoshimi Bando and Mitsuo Shimada : The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy., Anticancer Research, Vol.38, No.1, 501-507, 2018. (Summary) We report the outcomes of sorafenib therapy for advanced hepatocellular carcinoma (HCC) in our Department. Thirty-eight patients with unresectable HCC who were administrated sorafenib from 2009 to 2015 were investigated retrospectively. The 1-year overall survival rate was 59.3%. The macroscopic vascular invasion and response rate were independent prognostic factors of survival. Surgical resection after sorafenib achieved long-term survival in two cases. Case 1: A patient with locally unresectable HCC showed significant response induced by sorafenib, which allowed complete surgical resection. This tumor tested positive for FGF4. Case 2: A patient with a history of hepatectomy for HCC had multiple distant metastases. Most lesions were reduced in size after sorafenib therapy and new lesions in the remnant liver and residual lung metastases were resected. The sorafenib-resistant lesions were negative for FGF4. Sorafenib combined with surgical resection is a feasible option in advanced HCC patients, if sorafenib has been effective. (Keyword) Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Carcinoma, Hepatocellular / Combined Modality Therapy / Female / Fibroblast Growth Factor 4 / Hepatectomy / Hepatitis B / Humans / Liver Neoplasms / Male / Middle Aged / Niacinamide / Phenylurea Compounds / Retrospective Studies / Salvage Therapy / Sorafenib / Survival Rate (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.12250 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29277815 ● Summary page in Scopus @ Elsevier: 2-s2.0-85039796842 (DOI: 10.21873/anticanres.12250, PubMed: 29277815, Elsevier: Scopus)
26.	Hiroki Ishibashi, Mitsuo Shimada, Hiroki Mori, Yuji Morine and 安藤久實 : 【慢性炎症から肝胆膵癌にいたるランドスケープ】膵・胆管合流異常と胆道癌, KAN TAN SUI, Vol.77, No.3, 659-667, 2018. (Keyword) 和文論文
27.	Keigo Yada, Yuji Morine, Hiroki Ishibashi, Hiroki Mori and Mitsuo Shimada : Treatment strategy for successful hepatic resection of icteric liver., The Journal of Medical Investigation : JMI, Vol.65, No.1.2, 37-42, 2018. (Summary) The treatment strategy for jaundiced patients with hilar cholangiocarcinoma (HC) is not well established. In this study, we evaluate the feasibility of our perioperative protocol for jaundiced patients with HC. Twenty patients with HC who underwent hepatic resection at our institute were enrolled, and patients were divided into icteric(n=6) and normal(n=14) group. As a perioperative protocol, Oral administration of Inchinkoto(ICKT), steroid and nafamostat mesilate were introduced. The evaluation of functional future remnant liver(FRL) by asiaroscintigraphy, and postoperative outcomes were retrospectively compared. Indocyanine green dye retention rate at 15 minutes was higher, and LHL15 values was lower in icteric group. However, in the functional evaluation of FRL, which was the sum of GSA uptake of the future FRL, there was no significant difference of LHL15 values of the remnant liver functional reserve between the two groups. As results, according to the difference of liver function, serum AST level was not different between two groups. The number of patients with postoperative morbidity in the two groups was comparable. Even in HC patients with icteric liver, accurate assessment of liver functional reserve and effective perioperative treatment may attribute to successful hepatectomy and favorable post-operative outcomes. J. Med. Invest. 65:37-42, February, 2018. (Keyword) Aged / Aged, 80 and over / Bile Duct Neoplasms / Cholangiocarcinoma / Female / Hepatectomy / Humans / Jaundice, Obstructive / Male / Postoperative Complications / Retrospective Studies (Tokushima University Institutional Repository) ● Metadata: 111389 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.65.37 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593191 ● Search Scopus @ Elsevier (PMID): 29593191 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.65.37 (Tokushima University Institutional Repository: 111389, DOI: 10.2152/jmi.65.37, PubMed: 29593191)
28.	Shoko Wada, Hisami Okumura, Takafumi Katayama, Yuji Morine, Satoru Imura and Mitsuo Shimada : Major liver resection reduces nonprotein respiratory quotient and increases nonesterified fatty acid at postoperative day 14 in patients with hepatocellular carcinoma., Clinical Nutrition ESPEN, Vol.23, 194-199, 2017. (Tokushima University Institutional Repository) ● Metadata: 115066 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.clnesp.2017.10.001 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29460798 ● Summary page in Scopus @ Elsevier: 2-s2.0-85031825628 (Tokushima University Institutional Repository: 115066, DOI: 10.1016/j.clnesp.2017.10.001, PubMed: 29460798, Elsevier: Scopus)
29.	Keigo Yada, Hiroki Ishibashi, Hiroki Mori, Yuji Morine, Chengzhan Zhu, Rui Feng, Toru Kono and Mitsuo Shimada : The Kampo medicine "Daikenchuto (TU-100)" prevents bacterial translocation and hepatic fibrosis in a rat model of biliary atresia., Surgery, Vol.159, No.6, 1600-1611, 2016. (Summary) Biliary atresia is the most common cause of end-stage liver disease in children. It is known that bile duct ligation contributes to liver fibrosis via bacterial translocation (BT) and toll-like receptor 4 (TLR4) signaling of hepatic stellate cells (HSCs). We have reported previously that the traditional Japanese medicine, "Dai-kenchu-to (TU-100)," a form of "Kampo medicine" prevents BT in rats exposed to the stress of fasting. The aim of this study was to clarify the effect of TU-100 on a rat model of biliary atresia using bile duct ligation. Bile duct ligation and subsequent daily oral administration of TU-100 was performed in 6-week-old rats. The rats were killed at 3, 7, or 14 days after bile duct ligation to evaluate the liver injury, occurrence of BT, and hepatic fibrosis. As an in vitro experiment, we isolated fresh HSCs from the rats undergoing bile duct ligation. After cell attachment, TU-100 and its 3 component herbs (eg, processed ginger, ginseng radix, and Japanese pepper) were added, and the expressions of Alpha actin2 (acta2), Alpha-1 type I collagen (colIa1), and tissue inhibitor of metalloproteinase 1 (timp1) were analyzed. In vivo experiments demonstrated that oral administration of TU-100 decreased liver injury and atrophy of intestinal mucosa BT, hepatic fibrosis, and hepatic expression of alpha smooth muscle actin ( SMA) and TLR4, compared with rats that underwent bile duct ligation only. In vitro experiments showed that administration of TU-100 or the component herbs inhibited the expressions of acta2, colIa1, and timp1 in the HSCs. TU-100 prevented BT, activation of HSCs, and subsequent hepatic fibrosis. TU-100 may prevent progression of hepatic fibrosis in children with biliary atresia and improve prognosis. (Keyword) Actins / Animals / Bacterial Translocation / Biliary Atresia / Cell Culture Techniques / Disease Models, Animal / Hepatic Stellate Cells / Liver Cirrhosis / Male / Medicine, Kampo / Phytotherapy / Plant Extracts / Rats / Rats, Wistar / Toll-Like Receptor 4 (Tokushima University Institutional Repository) ● Metadata: 109712 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.surg.2016.02.002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26994485 ● Search Scopus @ Elsevier (PMID): 26994485 ● Search Scopus @ Elsevier (DOI): 10.1016/j.surg.2016.02.002 (Tokushima University Institutional Repository: 109712, DOI: 10.1016/j.surg.2016.02.002, PubMed: 26994485)
30.	Keigo Yada, Hiroki Ishibashi, Hiroki Mori, Yuji Morine and Mitsuo Shimada : 【イラストでみる最新の胆・膵消化管吻合術】肝管空腸吻合先天性胆道拡張症，戸谷分類IV-A型, Journal of Biliary Tract & Pancreas, Vol.37, No.3, 215-220, 2016. (Keyword) 空腸(外科的療法)
31.	Yuji Morine and Mitsuo Shimada : The value of systematic lymph node dissection for intrahepatic cholangiocarcinoma from the viewpoint of liver lymphatics., Journal of Gastroenterology, Vol.50, No.9, 913-927, 2015. (Summary) Lymph node (LN) metastasis from intrahepatic cholangiocarcinoma (IHCC) might be one of the most important indicators of aggressive surgical resection, yet the value of LN dissection is still controversial. To address this clinical problem, we need to better understand the multidirectional lymphatic outflow from the liver. Although most hepatic lymph flows into the hilar LNs along portal triads, there are also several lymphatic outflows directly communicating with distant areas or the general lymphatic system. Moreover, it has been revealed that LN metastasis spreads to more distal LNs through the hepatoduodenal ligament or other multidirectional lymphatic pathways connected to the general lymphatic system. Therefore, systematic LN dissection might merely be LN sampling in IHCC with LN metastasis. A multidisciplinary strategy focusing on adjuvant treatment after surgery is immediately necessary in these cases. In IHCC without LN metastasis, the accuracy of preoperative imaging assessment of LN metastasis is unsatisfactory and useless for detecting metastatic LNs in clinical settings. Therefore, prophylactic systematic LN dissection for IHCC without preoperative LN swelling is recommended for accurate LN status assessment and reduction of local recurrences. However, this procedure might not offer any clinical benefit according to the results of retrospective comparative studies. In this review, we summarize previous reports regarding lymphatic outflow of the liver and discuss LN dissection for IHCC. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-015-1071-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25833009 ● Search Scopus @ Elsevier (PMID): 25833009 ● Search Scopus @ Elsevier (DOI): 10.1007/s00535-015-1071-2 (DOI: 10.1007/s00535-015-1071-2, PubMed: 25833009)
32.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, Hiroki Ishibashi and Toru Utsunomiya : Detection of Lymph Nodes Metastasis in Biliary Carcinomas:Morphological Criteria by MDCT and the Clinical Impact of DEI-MRI, Hepato-Gastroenterology, Vol.62, No.140, 777-781, 2015. (Summary) This study was conducted to assess the usefulness of multi-slice CT (MDCT) and diffusion weighted MR images (DWI-MRI) for diagnosis of metastatic lymph nodes (LNs) in biliary carcinomas. Eighteen patients with biliary carcinomas (total 121 LNs) underwent surgical resection were included. In MDCT, the following criteria were measured: the maximum diameter, the enhanced value and the long and short axis (L/S) ratio. In DWI-MRI, the apparent diffusion coefficients (ADCs) were measured from ADC maps. In ROC analysis, the maximum diameter has the highest diagnostic power with area under curves of 0.903. And when the maximum diameter 8 mm and L/S ratio is less than 2, the accuracy was improved with a sensitivity of 81%, positive predictive value (PPV) of 45%. In DWI-MRI, ADCs values of metastatic LNs significantly lower than that of non-metastatic LNs (mean: 1.65 vs. 2.11 x10 3mm2/s). When the ADC value of 1.8 x10(-3) was used as a cut-off value, the best results were obtained with sensitivity of 75%, PPV of 82%. Using MDCT, diagnosis of LNs metastasis should be more than 8mm diameter and less than 2 of L/S ratio. In addition, DWI-MRI is more useful modality for diagnosis of LNs metastasis. (Keyword) 欧文論文 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26901999 ● Search Scopus @ Elsevier (PMID): 26901999 (PubMed: 26901999)
33.	Mami Kanamoto, Satoru Imura, Yuji Morine, Tohru Utsunomiya, Hiroki Mori, Yusuke Arakawa, Chie Takasu and Mitsuo Shimada : Effective use of a vessel-sealing system for laparoscopic unroofing of liver cysts., Asian Journal of Endoscopic Surgery, Vol.8, No.1, 91-94, 2015. (Summary) Liver cysts that present with symptoms such as jaundice, abdominal pain, and intra-cystic infection require treatment. In laparoscopic unroofing of liver cysts, appropriate treatment is needed in cases where the cystic walls contain vessels or bile ducts. A vessel-sealing system can seal not only vessels, but also bile ducts. We experienced four cases in which laparoscopic unroofing of liver cysts was performed with a vessel-sealing system. Case 1 was a woman in her 70s who presented at our hospital with abdominal pressure. Abdominal CT showed liver cysts with a maximum diameter of 13 cm. Laparoscopic unroofing was performed with LigaSure Impact. Case 2 was a woman in her 50s with abdominal discomfort. CT showed a cyst 15 cm in diameter situated in the right lobe. We performed SILS using a LigaSure Blunt Tip to unroof the cyst. Case 3 was a man in his 80s with abdominal pain. CT showed a huge cyst 25 cm in diameter in the right lobe. We performed hybrid SILS with a LigaSure Blunt Tip to unroof the cysts. Case 4 was a woman in her 70s with upper abdominal pain. CT showed multiple cysts with a maximum diameter of 15 cm in the bilateral lobes. We performed hybrid SILS to successfully unroof her cysts. None of the cases experienced postoperative complications, such as bleeding or bile leakage, and none experienced recurrence of cysts. A laparoscopic unroofing using a vessel-sealing system can be a minimally invasive and safe treatment for liver cysts. (Keyword) Aged / Aged, 80 and over / Blood Loss, Surgical / Cysts / Equipment Design / Female / Follow-Up Studies / Hepatectomy / Hepatic Artery / Hepatic Veins / Humans / Laparoscopy / Liver Diseases / Male / Middle Aged / Postoperative Hemorrhage / Suture Techniques / 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/ases.12134 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25598064 ● Summary page in Scopus @ Elsevier: 2-s2.0-84944232248 (DOI: 10.1111/ases.12134, PubMed: 25598064, Elsevier: Scopus)
34.	Mitsuo Shimada, Yuji Morine, Hiroaki Nagano, Etsuro Hatano, Takashi Kaiho, Masaru Miyazaki, Toru Kono, Toshiya Kamiyama, Satoshi Morita, Junichi Sakamoto, Mitsuo Kusano, Shigetoyo Saji, Takashi Kanematsu and Masaki Kitajima : Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001)., International Journal of Clinical Oncology, Vol.20, No.1, 95-104, 2015. (Summary) This multi-center, phase III trial assesses the efficacy of daikenchuto (TU-100) on gastrointestinal disorders after hepatic resection (UMIN Registration No. 000003103). A total of 231 patients, who underwent hepatic resection at 26 Japanese centers, were enrolled. Patients were randomly assigned to receive either oral doses (15 g/day, three times a day) of TU-100 or placebo control from preoperative day 3 to postoperative day 10, except on the day of surgery. Primary end points were the time from extubation until the first postoperative bowel movement (FBM-T), serum C-reactive protein (CRP) and ammonia levels. Finally, 209 patients (TU-100: n = 108, placebo: n = 101) were included in the statistical analysis. The median FBM-T was 88.2 h (95 % CI 74.0-94.1) in the TU-100 group and 93.1 h (95 % CI 83.3-99.4) in the placebo group, demonstrating that TU-100 accelerated the time to first bowel movement significantly more than placebo control. Serum CRP levels did not differ significantly during the study period, although serum CRP levels in the TU-100 group tended to be lower than those in the placebo group in patients with grade B liver damage. Meanwhile, the two groups had similar serum ammonia levels. TU-100-related serious adverse events did not occur during the study. TU-100 appears to improve gastrointestinal dysmotility and reduce serum CRP levels in patients with grade B liver damage after hepatectomy. TU-100 is an effective treatment option after hepatic resection in patients with liver cancer. (Keyword) Aged / Aged, 80 and over / Ammonia / Asian Continental Ancestry Group / C-Reactive Protein / Female / Gastrointestinal Diseases / Hepatectomy / Humans / Liver / Liver Neoplasms / Male / Medicine, East Asian Traditional / Middle Aged / Naphthoquinones / 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-014-0678-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24595550 ● Summary page in Scopus @ Elsevier: 2-s2.0-84894631671 (DOI: 10.1007/s10147-014-0678-2, PubMed: 24595550, Elsevier: Scopus)
35.	Chinbold Enkhbold, Yuji Morine, Tohru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shinichiro Yamada, Daichi Ishikawa and Mitsuo Shimada : Dysfunction of liver regeneration in aged liver after partial hepatectomy., Journal of Gastroenterology and Hepatology, Vol.30, No.7, 1217-1224, 2015. (Summary) A remarkable feature of the liver is its regenerative capacity following partial hepatectomy. However, the regenerative capacity of many organs and tissues loses its natural ability to divide with aging. In this study, we investigated the association of aging with endoplasmic reticulum stress, the cell cycle, autophagy, and apoptosis-related genes during liver regeneration after hepatectomy. Balb/c 4-week and 40-week-old male mice were subjected to 70% hepatectomy. Animals were sacrificed at 24, 48, and 72 h after hepatectomy. Immunohistochemical stainings for proliferating cell nuclear antigen, LC3, Atg5, and caspase-3 were used to quantify protein expression. Real-time reverse transcription-polymerase chain reaction was used to detect p16, CHOP, LC3, Atg5, hepatocyte growth factor, cMet, cyclin D1, cyclin A2, and caspase-3 expression. After hepatectomy, old group showed a lower survival rate and significantly lower expression of hepatocyte growth factor, cMet, cyclin D1, cyclin A2, proliferating cell nuclear antigen labeling index, and SMP30 compared with young group. The liver weight/body weight ratio was significantly lower at 48 h and 72 h after hepatectomy and was accompanied by markedly elevated levels of the liver cell injury markers, LC3 and caspase-3. Immunohistochemical results showed that LC3, Atg5, and caspase-3 protein expression were higher in old group than in young group. These results revealed that impaired liver regeneration was due to aging, which was expressed by decreased cell cycle and increased autophagy and apoptosis. Therefore, understanding the molecular basis for aged liver regeneration might provide a new therapeutic option for old patients. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/jgh.12930 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25682855 ● Search Scopus @ Elsevier (PMID): 25682855 ● Search Scopus @ Elsevier (DOI): 10.1111/jgh.12930 (DOI: 10.1111/jgh.12930, PubMed: 25682855)
36.	Tetsuya Ikemoto, Koji Sugimoto, Mitsuo Shimada, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Shinichiro Yamada : Clinical role of Notch signaling pathway in intraductal papillary mucinous neoplasm of the pancreas., Journal of Gastroenterology and Hepatology, Vol.30, No.1, 217-222, 2015. (Summary) This study was performed to elucidate the expression of the Notch signaling pathway and its correlations to clinicopathological factors of intraductal papillary mucinous neoplasms (IPMNs). It is incontrovertible that regulatory T cells (Tregs) play an important role in tumor immunity. However, the whole mechanism of control of peripheral Tregs remains unclear. It is also known that the Notch signaling pathway is involved in Treg suppressor function. Moreover, IPMNs have a high malignant potential. Peripheral blood samples and resected specimens from 18 patients with IPMN were evaluated. All patients were pathologically diagnosed with IPMN. Resected specimens were immunohistochemically evaluated (anti-Notch1, anti-Notch2, and anti-Notch2-intracellular domain antibody staining) and compared in terms of clinicopathological factors. Peripheral Treg populations were analyzed with an automated flow cytometer. Disease-free survival was significantly worse in the Notch1 high-expression group (P = 0.023). Notch2 family expressions were higher in intraductal papillary mucinous carcinoma (IPMC) than in intraductal papillary mucinous adenoma (IPMA) (Notch2, P = 0.012; Notch2-intracellular domain, P = 0.036). Jagged1 expression was significantly higher in IPMC than in IPMA (P < 0.05) and was significantly related to recurrence. The Treg population in peripheral blood was higher in patients with IPMC than in those with IPMA (P < 0.01). Notch signaling, especially Jagged1 expression, reflects IPMN aggressiveness. Our data may suggest that the Notch signaling pathway is a key pathway that determines IPMN pathological aggressiveness and reflects the peripheral Treg population. (Keyword) Adenocarcinoma, Mucinous / Aged / Calcium-Binding Proteins / Carcinoma, Pancreatic Ductal / Carcinoma, Papillary / Female / Gene Expression Regulation, Neoplastic / Humans / Intercellular Signaling Peptides and Proteins / Male / Membrane Proteins / Middle Aged / Pancreatic Neoplasms / Receptor, Notch1 / Receptor, Notch2 / Signal Transduction / 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/jgh.12660 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25041344 ● Search Scopus @ Elsevier (PMID): 25041344 ● Search Scopus @ Elsevier (DOI): 10.1111/jgh.12660 (DOI: 10.1111/jgh.12660, PubMed: 25041344)
37.	Kohei Sugihara, Hisami Okumura, Arisa Teramoto, Eri Urano, Takafumi Katayama, Yuji Morine, Satoru Imura, Tohru Utsunomiya, Mitsuo Shimada and Eiji Takeda : Recovery of nutritional metabolism after liver transplantation, Nutrition, Vol.31, No.1, 105-110, 2015. (Summary) Perioperative nutritional assessment is critically important to reflect nutritional management because liver transplantation (LTx) often is undertaken in patients with poor nutritional status. The aim of this study was to evaluate nutritional status, including the non-protein respiratory quotient (npRQ), resting energy expenditure (REE), nitrogen balance, and blood biochemical parameters in patients before and after LTx. Fourteen patients undergoing LTx and 10 healthy controls were enrolled in this study. The npRQ and REE were measured using indirect calorimetry before LTx and at 2, 3, and 4 wk after the procedure. Blood biochemistry and nitrogen balance calculated by 24-h urine collection were performed concurrently with indirect calorimetric measurement; the results were compared between the two groups. Before LTx, npRQ was significantly lower and serum non-esterified fatty acid levels were significantly higher in the patients than in the controls. Furthermore, a negative nitrogen balance was observed in the patients. These, however, improved significantly at 4 wk after LTx. REE did not significantly increase compared with the preoperative values in recipients. Blood biochemistry showed gradually increasing levels of serum cholinesterase and albumin. These failed to reach to normal levels by 4 wk post-transplant. The findings revealed that improvement of nutritional metabolism after LTx may require 4 wk. Additional nutritional strategies, therefore, may be needed to minimize catabolic state during the early post-transplant period. Adequate, individualized nutritional guidance before and after LTx should be performed in these patients. (Keyword) Body Mass Index / Body Weight / Calorimetry, Indirect / Case-Control Studies / Cholinesterases / energy metabolism / Fatty Acids, Nonesterified / Female / Humans / Liver Transplantation / Male / Middle Aged / Nitrogen / Nutrition Assessment / Nutritional Status / Perioperative Care / Serum Albumin (Link to Publication Site) ● Publication site (DOI): 10.1016/j.nut.2014.05.016 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25441593 ● Summary page in Scopus @ Elsevier: 2-s2.0-84922214411 (DOI: 10.1016/j.nut.2014.05.016, PubMed: 25441593, Elsevier: Scopus)
38.	Shin-ichiro Yamada, Mitsuo Shimada and Yuji Morine : 膵癌・胆道癌 ─基礎・臨床の最新研究動向─, Nihon Rinsho. Japanese Journal of Clinical Medicine, 618-621, 2015. (Keyword) 和文論文
39.	Michihito Asanoma, Hiroki Mori, Tetsuya Ikemoto, Toru Utsunomiya, Satoru Imura, Yuji Morine, Jun Hanaoka, Mami Kanamoto, Yu Saitou, Shinichiro Yamada and Mitsuo Shimada : Clinical role of Foxp3+ regulatory T cell in Living donor related liver transplantation for prediction of life-threatening complications., The Journal of Medical Investigation : JMI, Vol.62, No.1-2, 37-40, 2015. (Summary) It is no doubt that regulatory T cells (Foxp3(+)CD4(+)CD25(+)T cells: Treg) play important roles in transplant immunity. We investigated the significance of Treg expression in acute stage of living donorrelated liver transplantation (LDLT) for the possibility of the sensitive marker for immunological state and homeostatic stress after liver transplantation. Peripheral blood was drawn from 5 recipients of LDLT preoperatively and on post operative 1, 4, 7, and 14 days. The peripheral blood mononuclear cells (PBMCs) were stained with CD4, CD25, Foxp3, and were analyzed with FACScan. This data was compared with clinical output of LDLT. The populations of Treg were significantly decreased in all patients on day 1 after LDLT and significantly increased in patients who had early postoperative complications compared with patients who had no complications. The population of Treg in peripheral blood may reflect the surgical stress such as life-threatening complications after LDLT. (Keyword) 欧文論文 (Tokushima University Institutional Repository) ● Metadata: 111243 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.62.37 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25817281 ● Summary page in Scopus @ Elsevier: 2-s2.0-84925882618 (Tokushima University Institutional Repository: 111243, DOI: 10.2152/jmi.62.37, PubMed: 25817281, Elsevier: Scopus)
40.	Kayo Hirose, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tomiya Kawahara, Tomohiro Soga, Toshiko Katayama, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mitsuo Shimada, Munehide Matsuhisa and Hiroshi Kitahata : Usefulness of artificial endocrine pancreas during resection of insulinoma., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, 421-425, 2014. (Summary) A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state. The target concentration of blood glucose was set at 80-120 mg/dl during surgery. Until removal of the tumor, the blood glucose level was kept at around 80-100 mg/dl. After removal of the tumor, the blood glucose level gradually increased, but it was kept in the normal range by the artificial endocrine pancreas. The artificial endocrine pancreas was useful to monitor and maintain blood glucose levels during and after the removal of insulinoma, without any hyper- or hypoglycemia. J. Med. Invest. 61: 421-425, August, 2014. (Tokushima University Institutional Repository) ● Metadata: 109597 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.61.421 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264066 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907483198 (Tokushima University Institutional Repository: 109597, DOI: 10.2152/jmi.61.421, PubMed: 25264066, Elsevier: Scopus)
41.	Chengzhan Zhu, Tohru Utsunomiya, Tetsuya Ikemoto, Shinichiro Yamada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Chie Takasu, Daichi Ishikawa, Issei Imoto and Mitsuo Shimada : Hypomethylation of Long Interspersed Nuclear Element-1 (LINE-1) is Associated with Poor Prognosis via Activation of c-MET in Hepatocellular Carcinoma., Annals of Surgical Oncology, Vol.21, No.4, 729-735, 2014. (Summary) LINE-1 hypomethylation is significantly associated with poor prognosis in patients with HCC, possibly due to activation of c-MET expression. (Tokushima University Institutional Repository) ● Metadata: 109505 (Link to Publication Site) ● Publication site (DOI): 10.1245/s10434-014-3874-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24992910 ● Summary page in Scopus @ Elsevier: 2-s2.0-84940245895 (Tokushima University Institutional Repository: 109505, DOI: 10.1245/s10434-014-3874-4, PubMed: 24992910, Elsevier: Scopus)
42.	Yu Saitou, Hiroki Mori, Chie Takasu, Masato Komatsu, Jun Hanaoka, Shin-ichiro Yamada, 淺野間理仁, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : Beneficial effects of green tea catechin on massive hepatectomy model in rats., Journal of Gastroenterology, 2013. (Summary) BACKGROUND: Green tea catechin, especially epigallocatechin gallate (EGCG), is a well-known scavenger of reactive oxygen species and it may also function as an antioxidant through modulation of transcriptional factors and enzyme activities. METHODS: Green tea extract (GTE(®)) which contained numerous EGCG was used. Wistar rats were performed 90 % hepatectomy and classified into 2 groups with (GTEHx, n = 25) or without GTE treatment (Hx, n = 25) and sacrificed at 1, 3, 7 and 14 days after operations. All rats had free access to drinking water supplemented with or without GTE from the 7th pre-operative day. Liver regeneration, hepatic inducible nitric oxide synthase (iNOS), anti-oxidative enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)] and inflammatory markers [cyclooxygenase-2 (COX-2), nuclear factor kappa B (NFκB), tumor necrosis factor-α (TNF-α)] were investigated. RESULTS: The liver weight to body weight ratio (p < 0.01), proliferating cell nuclear antigen labeling index (p < 0.05) and phosphorylated extracellular signal-regulated kinase 1/2 (p < 0.05) at day 1 in the GTEHx group significantly increased compared to the Hx group. Hepatic iNOS levels at day 1 significantly decreased (p < 0.01) in the GTEHx group. Hepatic SOD, CAT and GSH-Px levels at day 1 significantly increased (SOD: p < 0.01, CAT and GSH-Px: p < 0.05) in the GTEHx group. In contrast, COX-2, NFκB and TNF-α levels at day 1 significantly decreased (COX-2: p < 0.01, NFκB and TNF-α: p < 0.05) in the GTEHx group. CONCLUSIONS: GTE pretreatment stimulated liver regeneration and improved liver damage after massive hepatectomy through anti-oxidative and anti-inflammatory effects. Green tea catechin might have the potential to attenuate liver dysfunction in early stage after massive hepatectomy. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-013-0799-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23543313 ● Summary page in Scopus @ Elsevier: 2-s2.0-84899985774 (DOI: 10.1007/s00535-013-0799-9, PubMed: 23543313, Elsevier: Scopus)
43.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Koji Sugimoto, Yu Saitou, Shinichiro Yamada and Michihito Asanoma : Beneficial effects of enteral nutrition containing with hydrolyzed whey peptide on warm ischemia/reperfusion injury in the rat liver., Hepatology Research, Vol.44, No.1, 114-121, 2013. (Summary) This study examined the efficacy of enteral nutrition containing hydrolyzed whey peptide (HWP) on warm ischemia/reperfusion (I/R) injury in the rat liver. Male Wistar rats were subjected to 30 min of warm hepatic ischemia followed by immediate p.o. intake of enteral nutrition with WHP (HWP group) or 20% glucose solution (control group) (0.025 mL/g). The animals were killed at 6 or 12 h after reperfusion. The serum aspartate aminotransferase (AST) and alanine aminotransferase alt (ALT) levels were measured. The necrotic areas were assessed histologically. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and caspase-3 activation were assessed to evaluate apoptosis. The expressions of hepatic tumor necrosis factor (TNF)-α, interleukin (IL)-6 and nuclear factor (NF)-κB in the liver tissue were assessed by real time reverse transcription polymerase chain reaction. Significant reductions in the serum AST and ALT levels were seen in the HWP group compared with the control group at both 6 and 12 h after reperfusion. The necrotic areas and numbers of TUNEL positive cells were significantly decreased in the HWP group at 6 and 12 h after reperfusion. The caspase-3/7 activities were significantly decreased in HWP group at 6 and 12 h after reperfusion. The mRNA expressions of TNF-α and IL-6 were significantly reduced in the HWP group at 12 h after reperfusion. NF-κB mRNA expression was significantly increased in the HWP group at 6 and 12 h after reperfusion. Enteral nutrition containing HWP ameliorated the hepatic warm I/R injury possibly through the suppression of pro-inflammatory cytokine expressions and the induction of NF-κB in the rat liver. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/hepr.12097 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23578099 ● Summary page in Scopus @ Elsevier: 2-s2.0-84891758377 (DOI: 10.1111/hepr.12097, PubMed: 23578099, Elsevier: Scopus)
44.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 淺野間理仁 : 肝切除支援ソフトによる術前シミュレーション，術中ナビゲーション，部分肝臓機能解析, JJSCAS, Vol.14, No.(3), 148-149, 2012.
45.	Satoru Imura, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hidenori Miyake and Mitsuo Shimada : [達人こだわりの手術テクニック] II. 肝胆膵領域 3. 肝癌に対する区域切除, Operation, Vol.66, No.(10), 1399-1405, 2012. (Keyword) Glisson一括処理 / 肝ハンギング / エネルギーデバイス (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521417755569899520 (CiNii: 1521417755569899520)
46.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura and Tetsuya Ikemoto : 「内視鏡外科医のための微細局所解剖アトラス」肝胆膵肝外側区域切除-脈管処理のコツ, 手術.2012, Vol.66, No.(6), 753-759, 2012.
47.	Toru Utsunomiya, Mitsuo Shimada, Jun Hanaoka, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Masafumi Harada : Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve, Journal of Gastroenterology, Vol.47, No.4, 470-476, 2012. (Summary) Preoperative estimation of the liver functional reserve is important in liver surgery. We evaluated the role of dynamic magnetic resonance (MR) imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), i.e., EOB-MRI, for determining liver functional reserve. Fifty patients who underwent EOB-MRI to examine their liver tumors were included in this study. We first performed a pixel-by-pixel comparison of registered MR images and activity images with Tc-99m galactosyl human serum albumin (GSA) on each slice, and the correlation coefficient was calculated for 8 patients. We also determined the correlation coefficient between the relative signal intensity (SI) values of EOB-MRI and preoperative liver function, such as the GSA, indocyanine green dye retention at 15 min (ICGR15), and prothrombin time. The mean of the correlation coefficients for 512 × 512 matrices between the EOB-MRI and the GSA was 0.83 ± 0.05 (ranging from 0.73 to 0.87). The correlation coefficient between the relative SI of the EOB-MRI and the receptor index (LHL15) of GSA was 0.56 (P < 0.01). Better correlation coefficients were observed between the relative SI and the liver function test, including ICGR15 (r = -0.67, P < 0.01) and prothrombin time (r = 0.59, P < 0.01). In a patient with hilar cholangiocarcinoma whose right hepatic duct was obstructed, the relative SI in the right lobe (2.4 ± 0.3) was significantly lower than that in the left lobe (3.1 ± 0.1). EOB-MRI represents a practical and reliable imaging technique that may be used to estimate regional liver functional reserve in the clinical setting. (Keyword) Adult / Aged / Aged, 80 and over / Contrast Media / Female / Gadolinium DTPA / Humans / Liver / Liver Function Tests / magnetic resonance imaging / Male / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-011-0513-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22170416 ● Summary page in Scopus @ Elsevier: 2-s2.0-84863084638 (DOI: 10.1007/s00535-011-0513-8, PubMed: 22170416, Elsevier: Scopus)
48.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine and Hidenori Miyake : [達人が教える肝胆膵高度技能専門医手術-コツとピットフォール] 肝葉切除(右肝・左肝切除)非手割法, Operation, Vol.66, No.(3), 287-293, 2012. (Keyword) Hanging maneuver / Hepatic vascular exclusion / anchor suture (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520854803472703488 (CiNii: 1520854803472703488)
49.	Yuji Morine and Mitsuo Shimada : Hepatic and pancreatic regenerative medicine using Adipose tissue-derived mesenchymal stem cell, Journal of Clinical and Experimental Medicine, Vol.42, No.(4), 303-308, 2012. (Keyword) 肝・膵再生医療 / 間葉系幹細胞(MSC) / 脂肪 / 肝細胞 / 膵β細胞 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521136279934467840 (CiNii: 1521136279934467840)
50.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Hidenori Miyake : 【内視鏡外科手術をめぐる最近のトピックス】新たな領域への手術適応保険収載後の腹腔鏡下肝切除術の展開, Gastroenterological Surgery, Vol.34, No.1, 69-77, 2011. (Keyword) 質問紙法; 医療保険; 肝細胞癌(外科的療法); 肝切除(有害作用); 空気塞栓症(病因); 術後合併症; 胆管癌(外科的療法); 胆管腫瘍(外科的療法); 腹腔鏡法(有害作用); 失血-外科; 近代医学史 / ヒト / 和文論文
51.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine and Tetsuya Ikemoto : 薬物治療学の進歩-この30年-，IX. 肝移植 1)ネオーラル(ノバルティス), KAN TAN SUI, Vol.61, No.6, 1170-1176, 2010. (Keyword) 和文論文
52.	Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, Satoru Imura, Hidenori Miyake and Nobuhiro Kurita : 術後障害に対する漢方治療., Surgical Therapy, Vol.103, No.3, 576-583, 2010. (Keyword) 和文論文 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1523951029955509888 (CiNii: 1523951029955509888)
53.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 岩橋衆一, 川田祐子 and 斎藤裕 : 問題を有するドナーからの生体肝移植 ∼胃癌術後ドナーおよび喘息罹患ドナー∼., The Japanese journal of clinical and experimental medicine, Vol.87, No.9, 1282-1283, 2010. (Keyword) 和文論文
54.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Jun Hanaoka : 急性肝不全に対する肝移植術施行のタイミングに難渋した症例, The Japanese journal of clinical and experimental medicine, Vol.87, No.9, 118-119, 2010. (Keyword) 和文論文
55.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, Yu Saito, Hisami Okumura and Eiji Takeda : Impact of splenectomy in patients with liver cirrhosis: Results from 18 patients in a single center experience., Hepatology Research, Vol.40, No.9, 894-900, 2010. (Summary) Aim: With the recent advances in medical or surgical treatments in chronic hepatic disorders, the indications for splenectomy in hepatic disorders have greatly expanded. We performed splenectomy for cirrhotic patients and investigated the effects of splenectomy on hepatic functional reserve and nutrition metabolism. Methods: Eighteen patients (Child-Pugh B/C: 12/6; Child-Pugh A: excluded) who underwent splenectomy at our institute between 2005 and 2008 were enrolled. Twelve patients (67%) had hepatocellular carcinoma (HCC), eight of whom met the Milan criteria. Results: Overall survival rate was 83.3% at 1 year and 62.7% at 2 years. The survival rate of six patients with liver cirrhosis classified a Child-Pugh C was 80.0% at 1 year and 60.0% at 2 years. Three patients underwent hepatic resection and nine patients received ablation therapy against hepatocelluar carcinoma. Portal pressure decreased after splenectomy in most patients (mean decrease, 4.7 mmHg). Four weeks after the operation, the markers of hepatic functional reserve, indocyanine green retention rate at 15 min (ICGR15) and Technetium-99m-galactosyl human serum albumin value ((99m)Tc-GSA), improved from 38.5% to 35.1% and from 0.773 to 0.788 (LHL15), respectively. The non-protein respiratory quotient (npRQ) did not change in short period after the operation. Other outcomes, including liver function test in cirrhotic patients with long-term (1 year) follow-up after splenectomy (n = 7), did not improve significantly. Post-operative complications included portal thrombus (n = 2), ascites (n = 2) were observed in six patients (33%). Conclusion: Splenectomy improved hepatic functional reserve and nutritional metabolism in some cases. However, the long-term outcomes should still be evaluated. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2010.00688.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20887594 ● Search Scopus @ Elsevier (PMID): 20887594 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1872-034X.2010.00688.x (DOI: 10.1111/j.1872-034X.2010.00688.x, PubMed: 20887594)
56.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura and Tetsuya Ikemoto : 特集/必読最新の肝切除—その2 2.Liver hanging maneuver, Surgery, Vol.72, No.5, 461-465, 2010. (Keyword) 和文論文 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001288081381504 (CiNii: 1390001288081381504)
57.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 岩橋衆一 and 斎藤裕 : 性差による肝胆膵疾患の臨床，病態，治療効果のDiscrepancy I.性差と各種肝疾患 7)肝移植と性差, KAN TAN SUI, Vol.60, No.5, 793-799, 2010. (Keyword) 和文論文
58.	Hisami Okumura, Taki Nakamura, Hidenori Miyake, Harumi Takeuchi, Takafumi Katayama, Yuji Morine, Satoru Imura, Mitsuo Shimada and Eiji Takeda : Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients., Hepatology Research, Vol.40, No.5, 470-476, 2010. (Summary) Aim: In patients with liver cirrhosis, abnormal energy metabolism induces low health-related quality of life (HRQOL) scores. However, late-evening snack (LES) prevents morning starvation in cirrhotic patients. Our aim is to assess the effect of long-term LES on HRQOL in cirrhotic patients, using the 36-item Short Form (SF-36) health survey. Methods: Thirty-nine cirrhotic patients classified as Child-Pugh grade A were recruited. The patients were randomly divided into two groups: 24 were assigned to the non-LES group and 15 to the LES group. SF-36 scores, anthropometric data and serum biochemical parameters were examined in the non-LES and LES groups at 0, 6 and 12 months. Results: Neither anthropometric data nor laboratory data showed significant differences between the non-LES and the LES groups at 0, 6 and 12 months. The role-emotional (RE) HRQOL scores at 6 months and mental health (MH) scores at 6 and 12 months were significantly reduced from the baseline level in the non-LES group. In contrast, these scores remained unchanged in the LES group. General health perception (GH) scores at 12 months, RE at 6 months and MH at 6 and 12 months in the LES group were significantly higher than those of the non-LES group. Conclusion: Long-term LES administration may be helpful in maintaining higher HRQOL in patients with cirrhosis. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2010.00637.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20412329 ● Search Scopus @ Elsevier (PMID): 20412329 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1872-034X.2010.00637.x (DOI: 10.1111/j.1872-034X.2010.00637.x, PubMed: 20412329)
59.	Mitsuo Shimada, Koji Sugimoto, Shuichi Iwahashi, Toru Utsunomiya, Yuji Morine, Satoru Imura and Tetsuya Ikemoto : CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma., Journal of Gastroenterology, Vol.45, No.8, 896-902, 2010. (Summary) CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer. However, no one has investigated the role of CD133 in intrahepatic cholangiocarcinoma (IHCC). The aim of this study was to clarify the clinical role of CD133 expression in IHCC. (Keyword) 欧文論文 / Aged / Aged, 80 and over / Antigens, CD / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Female / Gene Expression Regulation, Neoplastic / Glycoproteins / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / Male / Middle Aged / Multivariate Analysis / Neoplasm Metastasis / Peptides / Prognosis / Proportional Hazards Models / Survival Rate (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-010-0235-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20379837 ● Search Scopus @ Elsevier (PMID): 20379837 ● Search Scopus @ Elsevier (DOI): 10.1007/s00535-010-0235-3 (DOI: 10.1007/s00535-010-0235-3, PubMed: 20379837)
60.	荒川悠佑, Mitsuo Shimada, Hideaki Uchiyama, Satoru Imura, Yuji Morine, 金村普史, Jun Hanaoka, 金本真美, 杉本光司 and 西正暁 : Pseudostenosis of the Common Hepatic Duct caused by Compression of the Cystic Artery, The Japanese Journal of Gastroenterological Surgery, Vol.43, No.4, 405-410, 2010. (Summary) Bile duct way stenosis mimic malignant such as cholangiocellular carcinoma lesions and gall bladder carcinoma invasion. A 74-year-old woman a gallbladder (GB) polyp combined with common hepatic duct (CHD) stenosis was found in admitted for surgery to treat. Preoperative evaluation revealed to have a polypoid tumor 12mm in diameter and relatively smooth CHD stenosis. Because the possibility of malignancy could not be excluded, she underwent open abdominal surgery. We conducted the usual cholecystectomy. The CHD was compressed by the cystic artery, so we thoroughly confirmed the absence of any suspicious CHD lesion by directly inspecting the inner side of the stricture by choledochotomy. The definitive diagnosis of the GB tumor was early GB carcinoma. Although CHD compression by the cystic artery is considered uncommon, we suggest that it should be included in the differential diagnosis of extrahepatic biliary stenosis, especially when biliary stenosis is relatively smooth. (Keyword) 和文論文 (Link to Publication Site) ● Publication site (DOI): 10.5833/jjgs.43.405 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204916721408 ● Summary page in Scopus @ Elsevier: 2-s2.0-77953046874 (DOI: 10.5833/jjgs.43.405, CiNii: 1390001204916721408, Elsevier: Scopus)
61.	Erdenebulgan Batmunkh, Mitsuo Shimada, Yuji Morine, Satoru Imura, Hirofumi Kanemura, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, Koji Sugimoto and Masaaki Nishi : Expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) in patients with the gallbladder carcinoma., International Journal of Clinical Oncology, Vol.15, No.1, 59-64, 2010. (Summary) Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a central role in biologic processes under hypoxic conditions, especially concerning tumor angiogenesis. Vascular endothelial growth factor (VEGF) is a potent proangiogenic agent and a multifunctional angiogenic cytokine in many malignant tumors. (Keyword) 欧文論文 / Aged, 80 and over / Female / Gallbladder Neoplasms / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Immunohistochemistry / Male / Middle Aged / Neovascularization, Pathologic / Prognosis / Transcription Factors / Vascular Endothelial Growth Factor A (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-009-0011-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20082206 ● Search Scopus @ Elsevier (PMID): 20082206 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-009-0011-7 (DOI: 10.1007/s10147-009-0011-7, PubMed: 20082206)
62.	Hideaki Uchiyama, Mitsuo Shimada, Satoru Imura, Yuji Morine, Hirofumi Kanemura, Yusuke Arakawa, Mami Kanamoto, Masaaki Nishi and Jun Hanaoka : Living donor liver transplantation using a left hepatic graft from a donor with a history of gastric cancer operation., Transplant International, Vol.23, No.2, 234-235, 2010. (Keyword) 欧文論文 / Gastrectomy / Hepatic Artery / Humans / Liver Failure / Liver Transplantation / Living Donors / Male / Middle Aged / Stomach Neoplasms / Tissue Adhesions (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1432-2277.2009.00920.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19659795 ● Search Scopus @ Elsevier (PMID): 19659795 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1432-2277.2009.00920.x (DOI: 10.1111/j.1432-2277.2009.00920.x, PubMed: 19659795)
63.	Shinya Morimoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori and Jun Hanaoka : 肝癌ステージングと予後推定., 臨床消化器内科, Vol.25, No.4, 399-494, 2010. (Keyword) 和文論文
64.	Yuji Morine, Mitsuo Shimada, 久山寿子, 高松英夫 and Seiki Tashiro : 全国集計からみた先天性胆道拡張症, 膵・胆管合流異常の胆道癌発生率とその特徴, 胆と膵, Vol.31, No.11, 1293-1299, 2010. (Keyword) 和文論文 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572824500996378752 (CiNii: 1572824500996378752)
65.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一 and 斎藤裕 : 肝移植の画像診断ー生体ドナーの安全とレシピエントの予後向上をめざしてー, 肝胆膵画像, Vol.2, No.1, 69-78, 2010. (Keyword) 和文論文
66.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shinya Morimoto and Hiroki Mori : メタボリックシンドロームと肝細胞癌, G.I.Research, Vol.18, No.3, 224-230, 2010. (Keyword) 和文論文
67.	Hiroki Mori, Mitsuo Shimada, Yuji Morine, Satoru Imura, Kouzou Yoshikawa and Toru Utsunomiya : 肝・胆・膵手術と漢方, G I Research, Vol.18, No.4, 313-320, 2010. (Keyword) 和文論文 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573950400903287936 (CiNii: 1573950400903287936)
68.	Satoru Imura, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya, Hidenori Miyake and Mitsuo Shimada : 腹腔鏡下肝切除:腹腔鏡下肝切除術における最近の話題 ∼気腹とガス塞栓∼., 消化器外科, Vol.33, No.9, 1439-1444, 2010. (Keyword) 和文論文
69.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine and Tetsuya Ikemoto : 肝・胆道系症候群(Ⅱ)— その他の肝・胆道系疾患を含めて - 肝臓編(下)第2版 XIV 肝細胞癌以外の肝腫瘍「原発性肝肉腫(Primary hepatic sarcoma)」, 日本臨床2010, 276-280, 2010. (Keyword) 和文論文
70.	Tetsuya Ikemoto, Mitsuo Shimada, Shuichi Iwahashi, 川田祐子, Yu Saitou, Jun Hanaoka, Hiroki Mori, Satoru Imura, Yuji Morine and Toru Utsunomiya : 乳癌が併存するレシピエント，高度脂肪肝ドナーという組み合わせに施行した生体肝移植., The Japanese journal of clinical and experimental medicine, Vol.87, No.9, 1280-1281, 2010. (Keyword) 和文論文
71.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Hiroki Mori : 血液型不適合肝移植後interferon治療に難渋したC型肝炎の1例, The Japanese journal of clinical and experimental medicine, Vol.87, No.9, 1330-1331, 2010. (Keyword) 和文論文
72.	三宅秀則, 和田大助, Masahiko Fujii, Yuji Morine, Satoru Imura and Seiki Tashiro : 特集肝胆膵領域におけるエビデンスは?:胆嚢癌に対する肝SIVa SV切除の意義, 胆と膵, Vol.25, No.4, 207-212, 2004.
73.	宮本英典, Nobuhiro Kurita, 三宅秀則, Masahiko Fujii, 佐々木克哉, 高木敏秀, 鷹村和人, Yuji Morine, Satoru Imura and Seiki Tashiro : 当科におけるStageIVb膵癌の治療成績, Shikoku Acta Medica, Vol.59, No.1-2, 30-34, 2003. (Tokushima University Institutional Repository) ● Metadata: 110581 (Tokushima University Institutional Repository: 110581)

Academic Paper (Unrefereed Paper):

1.	Shuhai Chen, Yu Saitou, Yuhei Waki, Tetsuya Ikemoto, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : Generation of Highly Functional Hepatocyte-like Organoids from Human Adipose-Derived Mesenchymal Stem Cells Cultured with Endothelial Cells., Cells, Vol.13, No.6, 2024. (Summary) Previously, we successfully established a highly functional, three-dimensional hepatocyte-like cell (3D-HLC) model from adipose-derived mesenchymal stem cells (ADSCs) via a three-step differentiation protocol. The aim of the present study was to investigate whether generating hepatocyte-like organoids (H-organoids) by adding endothelial cells further improved the liver-like functionality of 3D-HLCs and to assess H-organoids' immunogenicity properties. Genes representing liver maturation and function were detected by quantitative reverse transcription-PCR analysis. The expression of hepatic maturation proteins was measured using immunofluorescence staining. Cytochrome P (CYP)450 metabolism activity and ammonia metabolism tests were used to assess liver function. H-organoids were successfully established by adding human umbilical vein endothelial cells at the beginning of the definitive endoderm stage in our 3D differentiation protocol. The gene expression of alpha-1 antitrypsin, carbamoyl-phosphate synthase 1, and apolipoprotein E, which represent liver maturation state and function, was higher in H-organoids than non-organoid 3D-HLCs. H-organoids possessed higher CYP3A4 metabolism activity and comparable ammonia metabolism capacity than 3D-HLCs. Moreover, although H-organoids expressed human leukocyte antigen class I, they expressed little human leukocyte antigen class II, cluster of differentiation (CD)40, CD80, CD86, and programmed cell death ligand 1, suggesting their immunogenicity properties were not significantly upregulated during differentiation from ADSCs. In conclusion, we successfully established an H-organoid model with higher liver-like functionality than previously established 3D-HLCs and comparable immunogenicity to ADSCs. (Keyword) Humans / Ammonia / Hepatocytes / Human Umbilical Vein Endothelial Cells / Mesenchymal Stem Cells / Organoids / HLA Antigens (Link to Publication Site) ● Publication site (DOI): 10.3390/cells13060547 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38534391 ● Search Scopus @ Elsevier (PMID): 38534391 ● Search Scopus @ Elsevier (DOI): 10.3390/cells13060547 (DOI: 10.3390/cells13060547, PubMed: 38534391)
2.	Chie Takasu, Yuji Morine, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada : Role of stromal PD-L1 expression in colorectal liver metastasis., BMC Cancer, Vol.24, No.1, 97, 2024. (Summary) The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed death-ligand 1 (PD-L1) expression and the prognosis of patients with colorectal cancer liver metastasis (CRLM). The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM. Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p = 0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p = 0.08). Stromal PD-L1-positive patients had longer overall survival (p = 0.003). Multivariate analysis identified stromal PD-L1 expression (p = 0.008) and poorer differentiation (p < 0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1- and low TIL groups had shorter OS than stromal PD-L1 + and high TIL groups (46.6% vs. 81.8%, p = 0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p = 0.03) and time to surgical failure (p = 0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p = 0.0002) and inversely related to the replacement subtype of the histological growth pattern (p = 0.008). Stromal PD-L1 expression may be a significant prognostic marker for CRLM. (Keyword) Humans / B7-H1 Antigen / Colorectal Neoplasms / Immune Checkpoint Inhibitors / Liver Neoplasms / Lymphocytes, Tumor-Infiltrating / Prognosis (Link to Publication Site) ● Publication site (DOI): 10.1186/s12885-024-11869-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38233811 ● Search Scopus @ Elsevier (PMID): 38233811 ● Search Scopus @ Elsevier (DOI): 10.1186/s12885-024-11869-8 (DOI: 10.1186/s12885-024-11869-8, PubMed: 38233811)
3.	Yuhei Waki, Yuji Morine, Takayuki Noma, Chie Takasu, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto and Mitsuo Shimada : Association between high expression of intratumoral fibroblast activation protein and survival in patients with intrahepatic cholangiocarcinoma., BMC Gastroenterology, Vol.23, No.1, 415, 2023. (Summary) Cancer-associated fibroblasts (CAFs) have been reported to exhibit protumorigenic effects. Among the well-known CAF markers such as smooth muscle actin (SMA) and fibroblast activation protein (FAP), high expression of SMA in the peritumoral stroma has been reported to be a prognostic factor in various cancers. However, the effect of high FAP expression in intrahepatic cholangiocarcinoma (IHCC) has not been fully clarified. We evaluated the expression of CAF markers, focusing on FAP expression in the peripheral and intratumoral regions, to clarify the association with survival in patients with IHCC. The study cohort comprised 37 patients who underwent curative resection for IHCC. The FAP expressions were evaluated in the peripheral and intratumoral regions of the resected tissues. Clinicopathological factors and survival outcomes were investigated between patients with high versus low FAP expression. Uni- and multivariate analyses were performed to identify the prognostic factors for overall survival and relapse-free survival. The median area percentages of FAP expression in the peripheral and intratumoral regions were 15.5% and 17.8%, respectively. High FAP expression in the intratumoral region was significantly associated with worse overall survival and disease-free survival than low FAP expression in the intratumoral region. Multivariate analysis identified high intratumoral FAP expression as a risk factor for worse overall survival (hazard ratio, 2.450; p = 0.049) and relapse-free survival (hazard ratio, 2.743; p = 0.034). High intratumoral FAP expression was associated with worse survival, suggesting that intratumoral FAP expression represents malignant progression in patients with IHCC. (Keyword) Humans / Neoplasm Recurrence, Local / Cholangiocarcinoma / Cancer-Associated Fibroblasts / Bile Ducts, Intrahepatic / Bile Duct Neoplasms / Prognosis (Tokushima University Institutional Repository) ● Metadata: 119225 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12876-023-03012-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38017374 ● Search Scopus @ Elsevier (PMID): 38017374 ● Search Scopus @ Elsevier (DOI): 10.1186/s12876-023-03012-x (Tokushima University Institutional Repository: 119225, DOI: 10.1186/s12876-023-03012-x, PubMed: 38017374)
4.	Yuhei Waki, Yu Saitou, Shuhai Chen, Tetsuya Ikemoto, Takayuki Noma, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : Effects of green light-emitting diode irradiation on hepatic differentiation of hepatocyte-like cells generated from human adipose-derived mesenchymal cells., Scientific Reports, Vol.13, No.1, 19954, 2023. (Summary) Light-emitting diode (LED) irradiation has been used in the differentiation of mesenchymal stem cells into a variety of cell types. This study investigated the effect of green LED (GLED) irradiation on the differentiation of adipocyte-derived mesenchymal cells into hepatocyte-like cells (HLCs) and the mechanism of its action. HLCs in the hepatocyte maturation phase were irradiated with GLED (520 nm, 21 W/m, 5 min/day for 10 days). The cells were then assessed for expression of hepatocyte maturity genes and opsin 3 (OPN3), hepatocyte function, viability, apoptosis, and levels of reactive oxygen species (ROS), intracellular adenosine triphosphate (ATP) and calcium ions (Ca). GLED irradiation increased Alpha-1 antitrypsin and Ornithine transcarbamylase gene expression, promoted Cytochrome P450 3A4 activity and urea synthesis, and elevated intracellular ROS, ATP and Ca levels. OPN3 expression was significantly more upregulated in GLED-irradiated HLCs than in the non-irradiated HLCs. No significant difference in cell viability or apoptosis was observed between GLED-irradiated and non-irradiated HLCs. GLED irradiation can promote hepatocyte maturation and functions through OPN3. GLED irradiation also stimulated mitochondrial function via Ca/ATP/ROS activation. GLED irradiation has potential to support cell-based transplantation in patients. (Keyword) Humans / Reactive Oxygen Species / Hepatocytes / Cell Differentiation / Adipocytes / Adenosine Triphosphate / Rod Opsins (Tokushima University Institutional Repository) ● Metadata: 119238 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-023-45967-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37968291 ● Search Scopus @ Elsevier (PMID): 37968291 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-45967-7 (Tokushima University Institutional Repository: 119238, DOI: 10.1038/s41598-023-45967-7, PubMed: 37968291)
5.	Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Sonoko Yasui-Yamada, Maki Nishi, Hiroshi Sakaue, Motomu Kamada, Tetsuya Matsuura and Mitsuo Shimada : Preoperative Weight Loss Program for Hepatocellular Carcinoma Patients with High Body Mass Index in Hepatectomy., World Journal of Surgery, Vol.47, No.12, 3348-3355, 2023. (Summary) This study aimed to investigate the usefulness of a weight-loss program (WLP) in patients with a high body mass index (BMI) prior to liver resection (Hx) for hepatocellular carcinoma (HCC). Among 445 patients with HCC who underwent initial Hx between 2000 and 2020, 19 with a high BMI (≥25.0) were enrolled in our WLP since 2014. For calorie restriction, the amount of energy consumed was calculated as the standard body weight (SBW) kg × 20-25 kcal/day. Protein mass was calculated as SBW kg × 1.0-1.2 g/day to maintain skeletal muscle mass. Patients also performed both aerobic and resistance exercises. The before-and-after changes were compared, and the effect of WLP on the short- and long-term results was investigated. The average length of WLP was 21 days, and weight loss was successfully achieved in all patients. Body fat mass was reduced during the program, while skeletal muscle mass was maintained. WLP led to improvements in liver function and fibrotic markers, without tumor progression. There were no postoperative complications (≥Clavien-Dindo [CD] III). A retrospective comparison between with and without WLP using propensity score-matching analysis revealed that WLP group showed better NLR value, however, there were no significant differences in both short and long-term outcomes after Hx based on participation in the WLP. WLP with multidisciplinary intervention improved immune-nutrition status and liver function of obese patients. WLP had not affected both short and long-term outcomes after Hx. (Keyword) Humans / Carcinoma, Hepatocellular / Hepatectomy / Liver Neoplasms / Body Mass Index / Weight Reduction Programs / Retrospective Studies / Propensity Score / Treatment Outcome / Laparoscopy (Link to Publication Site) ● Publication site (DOI): 10.1007/s00268-023-07220-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37840060 ● Search Scopus @ Elsevier (PMID): 37840060 ● Search Scopus @ Elsevier (DOI): 10.1007/s00268-023-07220-0 (DOI: 10.1007/s00268-023-07220-0, PubMed: 37840060)
6.	仲須千春, Shin-ichiro Yamada, Hiroki Teraoku, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 原因が不明であった肝palisading granulomaの1例, Acta Hepatologica Japonica, Vol.64, No.10, 504-509, 2023. (Summary) 患者は50代女性.検診の腹部超音波検査で肝S3に16×14mm大の腫瘤を指摘され精査加療目的に当科紹介となった.既往歴・生肉食歴なし.術前の血液検査で異常なく,末梢好酸球も正常.造影CTの動脈・門脈相では辺縁に造影効果を認めるが,平衡相では造影されず,MRI T1強調像で低信号,T2強調像で低∼等信号,拡散強調像でやや高信号であった.PET-CTで肝臓への集積は認めなった.悪性腫瘍の可能性を完全に否定できず,腹腔鏡下肝部分切除を施行した.病理組織学的には腫瘤全体に凝固壊死像が見られ,辺縁に線維増生を伴い,組織球が柵状に配列したpalisading granulomaであった.原因特定のために複数の染色を行ったが,病原体は同定できなかった.palisading granulomaは術前診断が困難であり,診断的治療として腹腔鏡下肝切除術は有用であると考えられた.(著者抄録) (Keyword) 肝切除肝臓疾患(病理学,画像診断,外科的療法) 超音波診断肉芽腫-好酸球性(病理学,画像診断,外科的療法) 腹腔鏡法幼虫移行症-内臓拡散MRI PET-CT検査ヒト中年(45∼64) 女 (Link to Publication Site) ● Publication site (DOI): 10.2957/kanzo.64.504 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2957/kanzo.64.504 (DOI: 10.2957/kanzo.64.504)
7.	Kouzou Yoshikawa, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Shoichiro Takao : Clinical impact of myosteatosis measured by magnetic resonance imaging on long-term outcomes of hepatocellular carcinoma after radical hepatectomy., BMC Surgery, Vol.23, No.1, 281, 2023. (Summary) A variety of factors have been reported to affect long-term outcomes after radical resection of hepatocellular carcinoma (HCC). However, the indicators remain controversial. The purpose of this study was to evaluate the relationship between myosteatosis of the multifidus muscle and long-term outcomes after radical surgery for HCC. We retrospectively analyzed clinicopathological data for 187 patients with HCC who underwent radical surgery at Tokushima University between January 2009 and December 2020 and measured the density of fat in the multifidus muscle at L3 on their preoperative magnetic resonance images (MRI). Associations of myosteatosis and clinicopathological factors with long-term outcomes were evaluated. The patients were divided into a myosteatosis-negative group (n = 122) and a myosteatosis-positive group (n = 65). The cancer-specific survival rate after hepatectomy was significantly worse in the myosteatosis-positive group than in the myosteatosis-negative group (p = 0.03). Univariate analysis identified multiple tumors, stage III/IV disease, an alfa-fetoprotein level ≥ 10 ng/ml, PIVKA-II ≥ 400 AU/ml, vp(+) status, and myosteatosis to be prognostic factors for cancer-specific survival. Multivariate analysis revealed multiple tumors, an alfa-fetoprotein level ≥ 10 ng/ml, and myosteatosis to be independent prognostic factors. Myosteatosis measured by MRI is a simple and useful predictor of the long-term outcome after radical surgery for HCC. (Keyword) Humans / Carcinoma, Hepatocellular / Hepatectomy / Retrospective Studies / Liver Neoplasms / Magnetic Resonance Imaging / Fetal Proteins (Tokushima University Institutional Repository) ● Metadata: 119226 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12893-023-02188-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37715229 ● Search Scopus @ Elsevier (PMID): 37715229 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-023-02188-z (Tokushima University Institutional Repository: 119226, DOI: 10.1186/s12893-023-02188-z, PubMed: 37715229)
8.	Shuhai Chen, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-B/STAT3 Axis., Anticancer Research, Vol.43, No.5, 1985-1992, 2023. (Summary) Macrophages are the most abundant immune cells in the tumor stroma, and their polarization states within the tumor microenvironment (TME) exert critical roles in tumorigenesis. TU-100 (Daikenchuto) is a commonly prescribed Japanese herbal medicine that has shown anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. However, its effects on tumor-associated macrophages (TAMs) remain unclear. TAMs were generated by macrophage exposure to tumor-conditioned medium (CM), and their polarization states were evaluated after TU-100 treatment. The underlying mechanism was further studied. TU-100 exhibited little cytotoxicity over a range of doses in M0 macrophages and TAMs. However, it could antagonize the M2-like polarization of macrophages evoked by tumor-CM exposure. These effects might be caused by the inhibition of TLR4/NF-B/STAT3 signaling in the M2-like phenotype of macrophages. Interestingly, TU-100 antagonized the malignancy promoting effects of M2 macrophages on hepatocellular carcinoma cell lines in vitro. Mechanistically, the administration of TU-100 restrained the high expression of MMP-2, COX-2, and VEGF in TAMs. TU-100 may alleviate the progression of cancer by regulating the M2 polarization of macrophages within the TME, suggesting a viable therapeutic approach. (Keyword) Humans / Cell Line, Tumor / Cell Polarity / Macrophages / Naphthoquinones / NF-kappa B / Signal Transduction / Tumor Microenvironment / Antineoplastic Agents, Phytogenic / Carcinoma, Hepatocellular (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.16359 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37097685 ● Search Scopus @ Elsevier (PMID): 37097685 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.16359 (DOI: 10.21873/anticanres.16359, PubMed: 37097685)
9.	Takayuki Noma, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 術前に肝細胞癌との鑑別が困難であった筋腫型肝血管筋脂肪腫の1例, Acta Hepatologica Japonica, Vol.64, No.4, 201-208, 2023. (Summary) 患者は40代女性.検診で肝から突出する15cmの巨大腫瘤を指摘され,精査加療目的に当科紹介となった.既往歴や背景肝に特記事項なく,腫瘍マーカーは正常であったが,造影CTの動脈・門脈相で肝右葉に15cm大の早期濃染と遅延相でwashoutを認めた.EOB-MRI肝細胞相ではdefectとして描出され肝細胞癌が疑われた.破裂の危険性を考慮し,まずTACEを行い,その後拡大肝右葉切除を施行した.病理組織学的には腫瘍の大半が平滑筋様細胞で構成されており,脂肪細胞は認めず,免疫組織化学染色にてVimentin,αSMA,HMB-45,melan Aが陽性であり,Perivascular epithelioid cell tumor(PEComa)として包括される腫瘍群の中の筋腫型の肝血管筋脂肪腫(Angiomyolipoma;AML)と診断した.今回我々は,術前に肝細胞癌との鑑別が困難であった,若年女性に発生した肝原発筋腫型AMLを経験したため報告する.(著者抄録) (Keyword) 肝細胞癌肝切除肝臓腫瘍(画像診断,病理学,外科的療法) 筋腫(画像診断,病理学,外科的療法) 鑑別診断術前評価超音波診断 X線CT 免疫組織化学 *血管筋脂肪腫(画像診断,病理学,外科的療法) 拡散MRI 腹部CT ヒト女 (Link to Publication Site) ● Publication site (DOI): 10.2957/kanzo.64.201 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2957/kanzo.64.201 (DOI: 10.2957/kanzo.64.201)
10.	Hiroki Mori, Takayuki Noma, Yuji Morine, Hiroki Ishibashi and Mitsuo Shimada : Carcinogenic risk in the biliary epithelium of children with congenital biliary dilatation via the DNA damage repair pathway., Surgery Today, Vol.53, No.10, 1126-1131, 2023. (Summary) Congenital biliary dilatation (CBD) is a high-risk factor for biliary tract cancer (BTC). We previously reported the potential for carcinogenesis in the biliary epithelium of patients with CBD. In this study, we investigated potential carcinogenetic pathways, focusing on the DNA damage repair response, in children with CBD and compared the findings with those in adults. We enrolled 6 children with CBD and 10 adults with CBD without BTC who underwent extrahepatic bile duct resections, plus 4 control patients who underwent pancreaticoduodenectomy for non-biliary cancer. Levels of phosphorylated histone H2AX (γH2AX), MRE11, and Ku-70 in the biliary tract epithelium were evaluated by immunohistochemistry. The levels of γH2AX, MRE11, and Ku-70 were significantly higher in the gallbladder epithelium and bile duct epithelium of both children and adults than in controls. Children and adults with CBD might develop BTC via the DNA damage repair pathway, as evidenced by increased γH2AX, MRE11, and Ku-70 expression. (Keyword) Adult / Humans / Child / Choledochal Cyst / Carcinogens / Biliary Tract / Epithelium / Biliary Tract Neoplasms / Carcinogenesis / DNA Damage / Dilatation, Pathologic (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-023-02664-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36828910 ● Search Scopus @ Elsevier (PMID): 36828910 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-023-02664-2 (DOI: 10.1007/s00595-023-02664-2, PubMed: 36828910)
11.	Katsuki Miyazaki, Yuji Morine, Caiming Xu, Chiharu Nakasu, Yuuma Wada, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Mitsuo Shimada and Ajay Goel : Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma., Cells, Vol.12, No.4, 612, 2023. (Summary) Lenvatinib is a multi-kinase inhibitor approved as a first-line treatment for patients with unresectable advanced hepatocellular carcinoma (HCC). However, its response rate is unsatisfactory, primarily due to the acquisition of resistance, which limits its clinical significance for treating patients with HCC. Recent evidence suggests that epidermal growth factor receptor (EGFR) activation can trigger Lenvatinib-resistance; and is considered an important therapeutic target in HCC. Curcumin, one of the most studied naturally occurring botanicals with robust anti-cancer activity, is also reported to be a potent tyrosine kinase inhibitor. In this study, we hypothesized that the anti-EGFR potential of Curcumin might help overcome Lenvatinib resistance in HCC. We established two Lenvatinib-resistant cells and discovered that a combination of Curcumin and Lenvatinib exhibited a synergistic anti-tumor efficacy in the resistant HCC cell lines. In line with previous reports, Lenvatinib-resistant cell lines revealed significant activation of the EGFR, and genomewide transcriptomic profiling analysis identified that the PI3K-AKT pathway was associated with Lenvatinib resistance. The combination treatment with Curcumin and Lenvatinib dramatically suppressed gene and protein expression of the EGFR-PI3K-AKT pathway, suggesting Curcumin overcomes Lenvatinib resistance via inhibition of EGFR. We further validated these findings in tumor spheroids derived from resistant cell lines. In conclusion, we, for the first time, report that Curcumin reverses Lenvatinib resistance in HCC, and that their combination has clinical application potential for adjunctive treatment in HCC. (Keyword) Humans / Carcinoma, Hepatocellular / Curcumin / Liver Neoplasms / Proto-Oncogene Proteins c-akt / Phosphatidylinositol 3-Kinases / Cell Line, Tumor / Signal Transduction / Protein Kinase Inhibitors / ErbB Receptors (Tokushima University Institutional Repository) ● Metadata: 118580 (Link to Publication Site) ● Publication site (DOI): 10.3390/cells12040612 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36831279 ● Search Scopus @ Elsevier (PMID): 36831279 ● Search Scopus @ Elsevier (DOI): 10.3390/cells12040612 (Tokushima University Institutional Repository: 118580, DOI: 10.3390/cells12040612, PubMed: 36831279)
12.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Yuhei Waki, Takayuki Noma, Tetsuya Ikemoto and Mitsuo Shimada : Multiplication of tumor maximum diameter and number as a new surgical indicator for Barcelona Clinic Liver Cancer intermediate-stage hepatocellular carcinoma., Hepatology Research, Vol.53, No.6, 531-539, 2023. (Summary) Recent advances in treatment modalities have been made, limiting the indication of hepatic resection in the treatment strategy for hepatocellular carcinoma (HCC) patients. This retrospective study investigated the significance of multiplication of tumor maximum diameter and number (MDN) as a surgical indicator for Barcelona Clinic Liver Cancer intermediate-stage HCC. A total of 49 patients with Barcelona Clinic Liver Cancer intermediate-stage HCC who underwent curative hepatic resection between 2000 and 2020 were enrolled in this study. Prognostic factors of overall survival and disease-free survival, including the product of MDN, were analyzed. Patients with MDN >12 experienced significantly worse prognosis compared with those with MDN ≤12 (p = 0.0395), and 5-year overall survival rates after hepatic resection were 60.0% and 23.4%, respectively. Furthermore, the disease-free survival rate of patients with MDN >12 was significantly worse compared with those with MDN ≤12 (p = 0.0049), and all patients with MDN >12 experienced recurrence within 3 years after hepatic resection. In the multivariate analysis, MDN >12 was identified as the only independent prognostic factor of both overall survival and disease-free survival. In addition, patients with MDN >12 suffered from uncontrollable recurrence by locoregional treatment, such as more than four intrahepatic and extrahepatic recurrences, after hepatic resection. MDN index might be a new surgical indicator for Barcelona Clinic Liver Cancer intermediate-stage HCC, and influence clinical decision-making for individual treatment strategies. (Link to Publication Site) ● Publication site (DOI): 10.1111/hepr.13887 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36755370 ● Search Scopus @ Elsevier (PMID): 36755370 ● Search Scopus @ Elsevier (DOI): 10.1111/hepr.13887 (DOI: 10.1111/hepr.13887, PubMed: 36755370)
13.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Yuhei Waki, Chiharu Nakasu and Mitsuo Shimada : Impact of apparent diffusion coefficient on prognosis of early hepatocellular carcinoma: a case control study., BMC Surgery, Vol.23, No.1, 6, 2023. (Summary) We investigated the usefulness of apparent diffusion coefficients (ADC) from diffusion-weighted images (DWI) obtained using magnetic resonance imaging (MRI) for prognosis of early hepatocellular carcinoma (HCC): Barcelona Clinic Liver Cancer (BCLC) stage 0 and A. We enrolled 102 patients who had undergone surgical resection for early HCC: BCLC stage 0 and A, and calculated their minimum ADC using DWI-MRI. We divided patients into ADC (n = 72) and ADC (n = 30) groups, and compared clinicopathological factors between the two groups. The ADC group showed higher protein induced by vitamin K absence-II (PIVKA-II) levels (p = 0.02) compared with the ADC group. In overall survival, the ADC group showed significantly worse prognosis than the ADC group (p < 0.01). Univariate analysis identified multiple tumors, infiltrative growth, high PIVKA-II, and low ADC value as prognostic factors. Multivariate analysis identified infiltrative growth and low ADC value as an independent prognostic factor. ADC values can be used to estimate the prognosis of early HCC. (Keyword) Humans / Carcinoma, Hepatocellular / Liver Neoplasms / Case-Control Studies / Retrospective Studies / Prognosis (Tokushima University Institutional Repository) ● Metadata: 118558 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12893-022-01892-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36631851 ● Search Scopus @ Elsevier (PMID): 36631851 ● Search Scopus @ Elsevier (DOI): 10.1186/s12893-022-01892-6 (Tokushima University Institutional Repository: 118558, DOI: 10.1186/s12893-022-01892-6, PubMed: 36631851)
14.	Katsuki Miyazaki, Yuuma Wada, Keisuke Okuno, Tatsuro Murano, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroaki Ikematsu, Yusuke Kinugasa, Mitsuo Shimada and Ajay Goel : An exosome-based liquid biopsy signature for pre-operative identification of lymph node metastasis in patients with pathological high-risk T1 colorectal cancer., Molecular Cancer, Vol.22, No.1, 2, 2023. (Summary) According to current guidelines, more than 70% of patients with invasive submucosal colorectal cancer (T1 CRC) undergo a radical operation with lymph node dissection, even though only ~ 10% have lymph node metastasis (LNM). Hence, there is imperative to develop biomarkers that can help robustly identify LNM-positive patients to prevent such overtreatments. Given the emerging interest in exosomal cargo as a source for biomarker development in cancer, we examined the potential of exosomal miRNAs as LNM prediction biomarkers in T1 CRC. We analyzed 200 patients with high-risk T1 CRC from two independent cohorts, including a training (n = 58) and a validation cohort (n = 142). Cell-free and exosomal RNAs from pre-operative serum were extracted, followed by quantitative reverse-transcription polymerase chain reactions for a panel of miRNAs. A panel of four miRNAs (miR-181b, miR-193b, miR-195, and miR-411) exhibited robust ability for detecting LNM in the exosomal vs. cell-free component. We subsequently established a cell-free and exosomal combination signature, successfully validated in two independent clinical cohorts (AUC, 0.84; 95% CI 0.70-0.98). Finally, we developed a risk-stratification model by including key pathological features, which reduced the false positive rates for LNM by 76% without missing any true LNM-positive patients. Our novel exosomal miRNA-based liquid biopsy signature robustly identifies T1 CRC patients at risk of LNM in a preoperative setting. This could be clinically transformative in reducing the significant overtreatment burden of this malignancy. (Keyword) Humans / Lymphatic Metastasis / Exosomes / Colorectal Neoplasms / Biomarkers, Tumor / MicroRNAs / Liquid Biopsy (Tokushima University Institutional Repository) ● Metadata: 118926 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12943-022-01685-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36609320 ● Search Scopus @ Elsevier (PMID): 36609320 ● Search Scopus @ Elsevier (DOI): 10.1186/s12943-022-01685-8 (Tokushima University Institutional Repository: 118926, DOI: 10.1186/s12943-022-01685-8, PubMed: 36609320)
15.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : Fontan associated liver disease(FALD)関連肝癌に対しての腹腔鏡肝切除の1例 Fontan循環における肝離断対策, Acta Hepatologica Japonica, Vol.64, No.1, 18-25, 2023. (Summary) 30代男性,3歳時に単心房・単心室症を背景にFontan手術を受けた.Fontan associated liver disease(FALD)として肝臓内科にフォローを開始されて以来3年後にFALD関連肝癌を疑われ,腹腔鏡肝切除を施行した.肝離断中は,Central venous pressure(CVP)圧を下げるため,positive end expiratory pressureをオフし,最小限の輸液量,利尿剤併用しながらの麻酔管理を行うも,Fontan循環の影響でCVPコントロールは不良で,静脈性出血が継続したままの肝離断となった.本症例は,術後合併症なく経過したものの,FALD関連肝癌症例は,Fontan循環による高CVP下での肝離断を余儀なくされるため,そのジレンマを解決する必要があり,その対策に関して考察を加え報告する.(著者抄録) (Keyword) 肝細胞癌(画像診断,病理学,外科的療法) 肝切除肝内胆管(画像診断,病理学,外科的療法) 超音波診断胆管癌(画像診断,病理学,外科的療法) 胆管腫瘍(画像診断,病理学,外科的療法) X線CT 中心静脈圧 *腹腔鏡法免疫組織化学複合腫瘍と混合腫瘍(画像診断,病理学,外科的療法) 超音波外科拡散MRI 腹部CT ヒト成人(19∼44) 男 (Link to Publication Site) ● Publication site (DOI): 10.2957/kanzo.64.18 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2957/kanzo.64.18 (DOI: 10.2957/kanzo.64.18)
16.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Shohei Okikawa, Katsuki Miyazaki, Chiharu Nakasu, Takayuki Noma, Akira Takahashi and Mitsuo Shimada : Impact of pancreatic resection in patients with liver cirrhosis., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 189-194, 2023. (Summary) Several reports have shown a high mortality rate in patients with liver cirrhosis (LC) who undergo pancreaticoduodenectomy, however, there are few reports on its long-term prognosis. Twelve patients with LC who had undergone pancreatic resection were enrolled. To compare clinicopathological variables, 159 non-LC patients who had undergone resection for pancreatic cancer were enrolled. Pancreaticoduodenectomy (PD) was performed in 5 LC patients and distal pancreatectomy (DP) was performed in 7 LC patients. Patients in the LC group had more co-morbidities, lower platelet counts and higher Fib4 index than the non-LC group. The postoperative complication rate was higher in the LC group (83.3% vs 47.8%). While the postoperative hospital stay and 30-day mortality rate were not different, the 90-day mortality rate was higher in the LC group (25.0% vs 2.5% ; p<0.01). Comparison by operative procedure showed no significant differences of postoperative outcomes in DP cases. However, in PD cases, postoperative complications were more frequent (100% vs 42.3%) and 90-day mortality was higher (40.0% vs 2.9% ; p<0.01) in the LC group. PD resulted in higher postoperative morbidity and mortality rates in patients with LC compared with non-LC patients. DP could be tolerated in the LC patients. J. Med. Invest. 70 : 189-194, February, 2023. (Keyword) Humans / Pancreatectomy / Treatment Outcome / Retrospective Studies / Pancreaticoduodenectomy / Pancreatic Neoplasms / Postoperative Complications / Liver Cirrhosis (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.189 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164719 ● Search Scopus @ Elsevier (PMID): 37164719 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.189 (DOI: 10.2152/jmi.70.189, PubMed: 37164719)
17.	Baasansuren Selenge, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Hiroki Teraoku, Shohei Okikawa and Mitsuo Shimada : Impact of L-type amino acid transporter 1 on intrahepatic cholangiocarcinoma., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 160-165, 2023. (Summary) Amino acid transporters, such as L-type amino acid transporter 1 (LAT1), have an effect on tumor growth, metastasis, and survival of various solid tumors. However, the role of LAT1 in patients with intrahepatic cholangiocarcinoma (IHCC) remains unknown. Forty-six patients who had undergone initial hepatic resection for IHCC at Tokushima University Hospital were enrolled in this study. Immunohistochemical analysis of LAT1 and phosphorylated Akt (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were analyzed between LAT1-high and LAT1-low groups. The LAT1-high group showed a higher proportion of periductal infiltrating type and higher carcinoembryonic antigen/carbohydrate antigen 19-9 levels compared with the LAT1-low group. Multivariate analysis revealed that LAT1-high expression was an independent prognostic factor for disease-free survival. Furthermore, the proportion of p-AKT positivity was higher in the LAT1-high group than in the LAT1-low group. LAT1 expression was associated with poor prognosis of IHCC and higher p-Akt expression. J. Med. Invest. 70 : 160-165, February, 2023. (Keyword) Humans / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Biomarkers, Tumor / Cholangiocarcinoma / Prognosis / Proto-Oncogene Proteins c-akt (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.160 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164714 ● Search Scopus @ Elsevier (PMID): 37164714 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.160 (DOI: 10.2152/jmi.70.160, PubMed: 37164714)
18.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Shohei Okikawa, Katsuki Miyazaki and Mitsuo Shimada : Short- and long-term outcomes of pancreatectomy in patients with hemodialysis., The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 105-109, 2023. (Summary) Several reports have shown the high mortality rate of pancreatic resection in patients with hemodialysis (HD), however, its long-term outcome remains unclear. In this study, we examined cases of pancreatic resection in patients with HD and conducted a literature review. Four patients with HD who underwent pancreatic resection from 2004 to 2019 were enrolled. To compare the clinicopathological variables of HD and non-HD patients, 161 non-HD patients who had undergone surgical resection for pancreatic cancer were enrolled. Among four cases of pancreatic resection with HD, three cases were malignant diseases. All patients with HD had some co-morbidities (100% in HD group, 45.3% in the non-HD group) and postoperative complications (100% in the HD group, vs 46.6% in the non-HD group). Although one patient had severe postoperative complications and length of postoperative hospital stay was longer, the 30- and 90-day mortality rates were both 0% in patients with HD. However, three cases in the HD group (75%) died approximately 6 months after surgery, including one cancer-related death. Pancreatic surgery in patients with HD should be carefully indicated, especially pancreaticoduodenectomy or total pancreatectomy, because of the poor prognosis induced by non-cancer-related causes of death. J. Med. Invest. 70 : 105-109, February, 2023. (Keyword) Humans / Pancreatectomy / Pancreatic Neoplasms / Pancreaticoduodenectomy / Postoperative Complications / Retrospective Studies (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.70.105 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164704 ● Search Scopus @ Elsevier (PMID): 37164704 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.105 (DOI: 10.2152/jmi.70.105, PubMed: 37164704)
19.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 【胆膵疾患と最新テクノロジーの融合】胆膵疾患における最新の術前術中手術支援システム, Journal of Biliary Tract & Pancreas, Vol.43, No.12, 1631-1636, 2022. (Summary) 胆膵手術における術前シミュレーションは,腫瘍進展範囲あるいは主要脈管解剖をいかに正確にイメージできるかが,ポイントとなる．空間認識力という意味で,extended realityは有用である．また,術中ナビゲーションに関しては,ICG蛍光法がゴールドスタンダードとなるが,人工知能を駆使した最新の知見,ならびに自験例も踏まえて,本稿で紹介する．(著者抄録) (Keyword) Indocyanine Green(診断的利用) 術中モニタリング人工知能膵臓疾患(X線診断,外科的療法) 膵頭十二指腸切除ソフトウェア X線CT 胆道疾患(X線診断,外科的療法) DICOM 蛍光血管撮影シミュレーション訓練手術ナビゲーションシステム胆管切除術ヒト
20.	Yuji Morine, Tohru Utsunomiya, Hisami Yamanaka-Okumura, Yu Saitou, Shin-ichiro Yamada, Tetsuya Ikemoto, Satoru Imura, Shohei Kinoshita, Akiyoshi Hirayama, Yasuhito Tanaka and Mitsuo Shimada : Essential amino acids as diagnostic biomarkers of hepatocellular carcinoma based on metabolic analysis., Oncotarget, Vol.13, 1286-1298, 2022. (Summary) Metabolomics, defined as the comprehensive identification of all small metabolites in a biological sample, has the power to shed light on phenotypic changes associated with various diseases, including cancer. To discover potential metabolomic biomarkers of hepatocellular carcinoma (HCC), we investigated the metabolomes of tumor and non-tumor tissue in 20 patients with primary HCC using capillary electrophoresis-time-of-flight mass spectrometry. We also analyzed blood samples taken immediately before and 14 days after hepatectomy to identify associated changes in the serum metabolome. Marked changes were detected in the different quantity of 61 metabolites that could discriminate between HCC tumor and paired non-tumor tissue and additionally between HCC primary tumors and colorectal liver metastases. Among the 30 metabolites significantly upregulated in HCC tumors compared with non-tumor tissues, 10 were amino acids, and 7 were essential amino acids (leucine, valine, tryptophan, isoleucine, methionine, lysine, and phenylalanine). Similarly, the serum metabolomes of HCC patients before hepatectomy revealed a significant increase in 16 metabolites, including leucine, valine, and tryptophan. Our results reveal striking differences in the metabolomes of HCC tumor tissue compared with non-tumor tissue, and identify the essential amino acids leucine, valine, and tryptophan as potential metabolic biomarkers for HCC. (Keyword) Humans / Amino Acids, Essential / Carcinoma, Hepatocellular / Tryptophan / Leucine / Liver Neoplasms / Valine (Link to Publication Site) ● Publication site (DOI): 10.18632/oncotarget.28306 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36441784 ● Search Scopus @ Elsevier (PMID): 36441784 ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.28306 (DOI: 10.18632/oncotarget.28306, PubMed: 36441784)
21.	Yuji Morine and Mitsuo Shimada : 【膵・胆管合流異常-先天性胆道拡張症の最新トピックス-】膵・胆管合流異常先天性胆道拡張症の分類と臨床的意義, Journal of Biliary Tract & Pancreas, Vol.43, No.11, 1507-1513, 2022. (Summary) 本邦で先天性胆道拡張症は,膵・胆管合流異常を合併するものと定義されていることから,戸谷分類のI型(Ibは除く)とIV-A型が対象となり,このため拡張胆管形態の分類に加えて,膵管胆管合流形態の分類も診断する必要がある．膵管胆管合流形態については,これまで合流形態のみの分類にとどまっていたが,臨床症状をより反映する分類が日本膵・胆管合流異常研究会診断基準検討委員会によって2015年に提案され,分類に応じて術中対処法も異なってくる．また拡張胆管に関しては,戸谷分類が広く引用されており,戸谷分類に応じて術中対処法だけでなく術後合併症も異なる．しかしながら,これまでの分類は一定の臨床的意義を示すものの,発生や病態,臨床症状,治療法すべてに対応する分類は依然確立されておらず,今後の検討課題と思われる．(著者抄録) (Keyword) 内視鏡的逆行性胆道膵管造影胆管造影胆汁うっ滞(病因) X線CT 分類超音波内視鏡検査三次元イメージング磁気共鳴胆道膵管造影膵胆管合流異常(画像診断) 胆道拡張症(画像診断,外科的療法) 吻合部狭窄(病因) MPR (Multiplanar Reconstruction) 胆管切除術胆道再建術(有害作用) ヒト
22.	Yuji Morine and Mitsuo Shimada : 【術前画像の読み解きガイド-的確な術式選択と解剖把握のために】胆道先天性胆道拡張症に対する胆管切除+胆道再建解剖把握と術中所見, Journal of Clinical Surgery, Vol.77, No.11, 274-281, 2022. (Summary) <文献概要>先天性胆道拡張症は,戸谷分類で5型に分類され,戸谷I型(Ibは除く)とIV-A型では,膵・胆管合流異常を合併する.膵液の胆道内への逆流(膵液胆道逆流現象)の防止および胆道癌発生予防の目的のため,(肝外)胆管切除+胆道再建術が標準術式として確立されているが,拡張胆管の切除が不十分であったり,肝門部胆管形成が不適切であれば,難治性胆管炎や肝内結石,遺残胆管癌などの術後合併症が危惧される.本稿では,先天性胆道拡張症における(肝外)胆管切除+胆道再建の術中・術後合併症を回避するための基本手技とともに,理解すべき術前・術中画像による解剖把握のポイントについて概説する. (Keyword) 局所解剖学術中期術前評価内視鏡的逆行性胆道膵管造影胆道外科磁気共鳴胆道膵管造影胆道拡張症(外科的療法,画像診断) 胆管切除術胆道再建術ヒト (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1407213920 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1407213920 (DOI: 10.11477/mf.1407213920)
23.	Baasansvren Selenge, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Hiroki Teraoku and Mitsuo Shimada : Impact of L-type amino acid transporter 3 on the prognosis of hepatocellular carcinoma., Oncology Letters, Vol.24, No.5, 418, 2022. (Summary) The aim of the present study was to investigate the impact of L-type amino acid transporter 3 (LAT3) expression on the prognosis of hepatocellular carcinoma (HCC). A total of 135 patients who had undergone initial hepatic resection for HCC at Tokushima University Hospital (Tokushima, Japan) were enrolled in the present study. Immunohistochemical analysis of LAT3 and phosphorylated AKT (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were compared between the LAT3-high and -low expression groups. The results demonstrated that the LAT3-high group showed significantly higher protein induced by vitamin K absence-II levels (P=0.01) compared with the LAT3-low group. The LAT3-high group showed significantly worse prognosis compared with the LAT3-low group regarding cancer-specific survival and disease-free survival (P<0.05). Multivariate analysis revealed that high LAT3 expression and multiple tumors were independent prognostic factors for cancer-specific survival. Furthermore, the rate of p-AKT-positive cases was higher in the LAT3-high group than in the LAT3-low group. Overall, these findings suggested that LAT3 expression was associated with poor prognosis of HCC and high p-AKT expression. (Tokushima University Institutional Repository) ● Metadata: 118271 (Link to Publication Site) ● Publication site (DOI): 10.3892/ol.2022.13538 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36245821 ● Search Scopus @ Elsevier (PMID): 36245821 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13538 (Tokushima University Institutional Repository: 118271, DOI: 10.3892/ol.2022.13538, PubMed: 36245821)
24.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : A Hepatectomy Based on a Hybrid Concept of Portal Perfusion of Anterior Segment and Venous Drainage Area of Superior Right Hepatic Vein., The American Surgeon, 3134820984872, 2022. (Summary) Right hepatic vein sometimes could not be a reliable landmark between the anterior and posterior segment. The aim of this study was to clarify the portal perfusion area of the anterior segment and to propose a less invasive hepatectomy based on both the portal perfusion and the hepatic venous drainage. Three-dimensional computerized tomography images of 66 patients were constructed. A case, in which the perfusion area of the anterior segment crossed over superior right hepatic vein (SRHV), was called as SRHV-inclusion. It was defined as inclusion of more than 1 cm of the proximal site of SRHV surrounded by the portal perfusion area of the anterior segment. SRHV-inclusion was observed in 26%. The cases with large inferior right hepatic vein (IRHV) had more frequent SRHV-inclusion (47%). The elderly patient with hepatic disorder, who had hepatocellular carcinoma near the root of the SRHV, underwent a less invasive hepatectomy (anterior segment + SRHV drainage area) resulting in the preservation of the IRHV. The perfusion area of the anterior segment crossed over SRHV in one fourth of patients in the study. Our proposed less invasive hepatectomy based on a hybrid concept might be an alternative operative procedure other than right hepatectomy. (Link to Publication Site) ● Publication site (DOI): 10.1177/0003134820984872 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33382339 ● Search Scopus @ Elsevier (PMID): 33382339 ● Search Scopus @ Elsevier (DOI): 10.1177/0003134820984872 (DOI: 10.1177/0003134820984872, PubMed: 33382339)
25.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Akiko Nakamoto, Tohru Sakai and Mitsuo Shimada : Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts., Oncology Letters, Vol.24, No.1, 236, 2022. (Summary) Sudachitin is a polymethoxylated flavone found in the peel of , a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti-inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer-associated fibroblasts (CAFs). Using lactate assays and reverse transcription-quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half-maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro-tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant. (Tokushima University Institutional Repository) ● Metadata: 118072 (Link to Publication Site) ● Publication site (DOI): 10.3892/ol.2022.13356 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35720469 ● Search Scopus @ Elsevier (PMID): 35720469 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2022.13356 (Tokushima University Institutional Repository: 118072, DOI: 10.3892/ol.2022.13356, PubMed: 35720469)
26.	Yu Saitou, Maki Sugimoto, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : Intraoperative support with three-dimensional holographic cholangiography in hepatobiliary surgery., Langenbeck's Archives of Surgery / Deutsche Gesellschaft für Chirurgie, Vol.407, No.3, 1285-1289, 2022. (Summary) This study was performed to investigate the potential of intraoperative three-dimensional (3D) holographic cholangiography, which provides a computer graphics model of the biliary tract, with mixed reality techniques. Two patients with intraductal papillary neoplasm of the bile duct were enrolled in the study. Intraoperative 3D cholangiography was performed in a hybrid operating room. Three-dimensional polygon data using the acquired cholangiography data were installed into a head mount display (HoloLens; Microsoft Corporation, Redmond, WA, USA). Upon completion of intraoperative 3D cholangiography, a hologram was immediately and successfully made in the operating room using the acquired cholangiography data, and several surgeons wearing the HoloLens succeeded in sharing the same hologram. Compared with usual two-dimensional cholangiography, this 3D holographic cholangiography technique contributed to more accurate reappearance of the bile ducts, especially the B1 origination site, and moving the hologram from the respective operators' angles by means of easy gesture-handling without any monitors. Intraoperative 3D holographic cholangiography might be a new next-generation operation-support tool in terms of immediacy, accurate anatomical reappearance, and ease of handling. (Keyword) Bile Duct Neoplasms / Bile Ducts / Biliary Tract / Cholangiography / Humans (Link to Publication Site) ● Publication site (DOI): 10.1007/s00423-021-02336-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34557939 ● Search Scopus @ Elsevier (PMID): 34557939 ● Search Scopus @ Elsevier (DOI): 10.1007/s00423-021-02336-0 (DOI: 10.1007/s00423-021-02336-0, PubMed: 34557939)
27.	Kazunori Tokuda, Tetsuya Ikemoto, Shoko Yamashita, Katsuki Miyazaki, Shohei Okikawa, Shin-ichiro Yamada, Yu Saitou, Yuji Morine and Mitsuo Shimada : Syngeneically transplanted insulin producing cells differentiated from adipose derived stem cells undergo delayed damage by autoimmune responses in NOD mice., Scientific Reports, Vol.12, No.1, 5852, 2022. (Summary) Insulin-producing cells (IPCs) generated by our established protocol have reached the non-clinical 'proof of concept' stage. Our strategy for their clinical application is the autotransplantation of IPCs into patients with type 1 diabetes mellitus (T1DM). In this context, the autoimmunity that characterized T1DM is important, rather than allorejection. We aimed to determine how these IPCs respond to T1DM autoimmunity. IPCs were generated from the subcutaneous fat tissue of non-obese diabetic (NOD) mice using our protocol. IPCs derived from NOD mice were transplanted under the kidney capsules of NOD mice at the onset of diabetes and the subsequent changes in blood glucose concentration were characterized. Blood glucose decreased within 30 days of transplantation, but increased again after 40-60 days in three of four recipient NOD mice. In tissue samples, the numbers of CD4 and CD8 T cells were significantly higher 60 days after transplantation than 30 days after transplantation. In conclusion, IPCs significantly ameliorate the diabetes of mice in the short term, but are damaged by autoimmunity in the longer term, as evidenced by local T cells accumulation. This study provides new insights into potential stem cell therapies for T1DM. (Keyword) Animals / Autoimmunity / Blood Glucose / CD8-Positive T-Lymphocytes / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 1 / Humans / Insulin / Insulin-Secreting Cells / Mice / Mice, Inbred NOD / Stem Cells (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-022-09838-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35393479 ● Search Scopus @ Elsevier (PMID): 35393479 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-09838-x (DOI: 10.1038/s41598-022-09838-x, PubMed: 35393479)
28.	Masaaki Nishi, Mitsuo Shimada, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Yuuma Wada : 【外科代謝栄養と東洋医学:漢方による周術期管理へのサポート】大建中湯による周術期管理のサポート, The Japanese Journal of Surgical Metabolism and Nutrition, Vol.56, No.2, 59-61, 2022. (Summary) 近年では漢方の分子生物学的な作用機序の解明が進み，臨床においても質の高いランダム化比較試験により漢方の有用性が明らかになってきた．現在では大建中湯を含む多くの漢方製剤が広く臨床の現場で用いられている．大建中湯は乾姜，人参，山椒の3つの生薬に膠飴を加えた漢方で，外科領域においては癒着性イレウスや麻痺性イレウス，過敏性腸症候群，クローン病などを適応とし，消化管運動促進作用，腸管血流増加作用，抗炎症作用などが報告されている．近年では，食道・胃・大腸・肝臓・膵臓・肝移植外科それぞれの領域でランダム化試験が実施され，大建中湯の周術期管理における有効性が証明されている．また分子生物学的なメカニズムについても解明がすすみ，現在，大建中湯は消化管外科・肝胆膵外科の分野を問わず消化器外科全般における周術期管理のkey drugとして位置付けられている．本稿では消化器外科領域における大建中湯による周術期管理のサポートについて概説する．(著者抄録) (Keyword) 消化管運動消化器外科バクテリアルトランスロケーション周術期管理 *大建中湯(薬理学,治療的利用) 伊東細胞腫瘍微小環境ヒト (Link to Publication Site) ● Publication site (DOI): 10.11638/jssmn.56.2_59 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.56.2_59 (DOI: 10.11638/jssmn.56.2_59)
29.	Shohei Okikawa, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Hiroki Teraoku, Katsuki Miyazaki, Shoko Yamashita, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Inhibition of the VEGF signaling pathway attenuates tumor-associated macrophage activity in liver cancer., Oncology Reports, Vol.47, No.4, 2022. (Summary) Tumor-associated macrophage (TAMs) are paramount for tumor progression and immune tolerance in the tumor microenvironment of various types of cancer, including liver cancer. The aim of the present study was to investigate the effect of vascular endothelial growth factor (VEGF) inhibition on TAM polarization and function during their interactions with macrophages and liver cancer cells. TAMs were induced by culturing M0 macrophages with cancer cell-conditioned medium. TAMs cultured with cancer cell-conditioned medium and vascular endothelial growth factor (VEGF) inhibitor were defined as modified TAMs, and the expression levels of TAM-associated markers and VEGF receptor 2 were evaluated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The effects of TAMs and modified TAMs on cancer cell proliferation and migration were investigated using conditioned medium. Programmed death-ligand 1 (PD-L1) mRNA expression in modified TAMs and cancer cells cultured in modified TAM-conditioned medium (TAM-CM) for 48 h was examined using RT-qPCR. In order to investigate signaling pathways in macrophages, western blot analysis was performed. CD163 and CD206 and M2 macrophage marker expression was upregulated in TAMs and modified TAMs. Modified TAM-CM exhibited a decreased ability to promote cancer cell proliferation and migration in comparison with the use of TAM-CM. The VEGF concentration was significantly higher in the TAMs than in M0 macrophages; however, the modified TAMs displayed a significantly lower VEGF secretion than TAMs. PD-L1 expression was decreased in modified TAMs as compared with TAMs. Western blot analysis revealed that the Akt/mTOR signaling pathway was significantly suppressed in the modified TAMs compared with TAMs. It was observed that TAMs cultured in a VEGF-depleted environment displayed lower secretion levels of cytokines involved in tumor progression and a decreased immune tolerance-inducing ability. On the whole, the results of the present study suggested that VEGF inhibition in TAMs may be a potential therapeutic target for liver cancer. (Keyword) Cell Line, Tumor / Humans / Liver Neoplasms / Signal Transduction / Tumor Microenvironment / Tumor-Associated Macrophages / Vascular Endothelial Growth Factor A (Tokushima University Institutional Repository) ● Metadata: 118964 (Link to Publication Site) ● Publication site (DOI): 10.3892/or.2022.8282 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35169858 ● Search Scopus @ Elsevier (PMID): 35169858 ● Search Scopus @ Elsevier (DOI): 10.3892/or.2022.8282 (Tokushima University Institutional Repository: 118964, DOI: 10.3892/or.2022.8282, PubMed: 35169858)
30.	Hiroki Mori, Kazunori Masahata, Satoshi Umeda, Yuji Morine, Hiroki Ishibashi, Noriaki Usui and Mitsuo Shimada : Risk of carcinogenesis in the biliary epithelium of children with congenital biliary dilatation through epigenetic and genetic regulation., Surgery Today, Vol.52, No.2, 215-223, 2022. (Summary) Congenital biliary dilatation (CBD), defined as pancreaticobiliary maljunction (PBM) with biliary dilatation, is a high risk factor for biliary tract cancer (BTC). KRAS and p53 mutations reportedly affect this process, but the mechanisms are unclear, as is the likelihood of BTC later in life in children with CBD. We investigated potential carcinogenetic pathways in children with CBD compared with adults. The subjects of this study were nine children with CBD and 13 adults with PBM (10 dilated, 3 non-dilated) without BTC who underwent extrahepatic bile duct resections, as well as four control patients who underwent pancreaticoduodenectomy for non-biliary cancer. We evaluated expressions of Ki-67, KRAS, p53, histone deacetylase (HDAC) and activation-induced cytidine deaminase (AID) in the biliary tract epithelium immunohistochemically. The Ki-67 labeling index (LI) and expressions of KRAS, p53, HDAC, and AID in the gallbladder epithelium were significantly higher or tended to be higher in both the children with CBD and the adults with PBM than in the controls. BTC may develop later in children with CBD and in adults with PBM, via HDAC and AID expression and through epigenetic and genetic regulation. (Keyword) Adult / Aged / Biliary Tract Neoplasms / Child / Child, Preschool / Choledochal Cyst / Epithelium / Female / Gallbladder / Gene Expression Regulation, Neoplastic / Histone Deacetylases / Humans / Infant / Ki-67 Antigen / Male / Middle Aged / Pancreaticobiliary Maljunction / Proto-Oncogene Proteins p21(ras) / Risk / Tumor Suppressor Protein p53 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-021-02325-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34132887 ● Search Scopus @ Elsevier (PMID): 34132887 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-021-02325-2 (DOI: 10.1007/s00595-021-02325-2, PubMed: 34132887)
31.	Sanae Hayashi, Masanori Isogawa, Keigo Kawashima, Kyoko Ito, Natthaya Chuaypen, Yuji Morine, Mitsuo Shimada, Nobuyo Higashi-Kuwata, Takehisa Watanabe, Pisit Tangkijvanich, Hiroaki Mitsuya and Yasuhito Tanaka : Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application., Scientific Reports, Vol.12, No.1, 2133, 2022. (Summary) The persistence of covalently closed circular DNA (cccDNA) poses a major obstacle to curing chronic hepatitis B (CHB). Here, we used droplet digital PCR (ddPCR) for cccDNA quantitation. The cccDNA-specific ddPCR showed high accuracy with the dynamic range of cccDNA detection from 10 to 10 copies/assay. The ddPCR had higher sensitivity, specificity and precisely than qPCR. The results of ddPCR correlated closely with serum HB core-related antigen and HB surface antigen (HBsAg) in 24 HBV-infected human-liver-chimeric mice (PXB-mice). We demonstrated that in 2 PXB-mice after entecavir treatment, the total cccDNA content did not change during liver repopulation, although the cccDNA content per hepatocyte was reduced after the treatment. In the 6 patients with HBV-related hepatocellular carcinoma, ddPCR detected cccDNA in both tumor and non-tumor tissues. In 13 HBeAg-negative CHB patients with pegylated interferon alpha-2a, cccDNA contents from paired biopsies were more significantly reduced in virological response (VR) than in non-VR at week 48 (p = 0.0051). Interestingly, cccDNA levels were the lowest in VR with HBsAg clearance but remained detectable after the treatment. Collectively, ddPCR revealed that cccDNA content is stable during hepatocyte proliferation and persists at quantifiable levels, even after serum HBsAg clearance. (Keyword) Animals / Carcinoma, Hepatocellular / DNA, Circular / DNA, Viral / Hepatitis B / Hepatitis B virus / Humans / Interferon-alpha / Liver / Mice, Transgenic / Polyethylene Glycols / Polymerase Chain Reaction / Recombinant Proteins (Tokushima University Institutional Repository) ● Metadata: 117386 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-022-05882-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35136096 ● Search Scopus @ Elsevier (PMID): 35136096 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-05882-9 (Tokushima University Institutional Repository: 117386, DOI: 10.1038/s41598-022-05882-9, PubMed: 35136096)
32.	Yuuma Wada, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hideo Baba, Masaki Mori and Ajay Goel : A blood-based noninvasive miRNA signature for predicting survival outcomes in patients with intrahepatic cholangiocarcinoma., British Journal of Cancer, Vol.126, No.8, 1196-1204, 2022. (Summary) The prognosis in patients with intrahepatic cholangiocarcinoma (ICC) is generally poor. To improve treatment selection, we sought to identify microRNA (miRNA) signature associated with survival outcomes in ICC. We first analysed the miRNA expression profiles of primary ICC from two public datasets to identify a miRNA panel to detect patients for short-term survival. We then analysed 309 specimens, including 241 FFPE samples from two clinical cohorts (training: n = 177; validation: n = 64) and matched plasma samples (n = 68), and developed a risk-stratification model incorporating the panel and CA 19-9 levels to predict survival outcomes in ICC. We identified a 7-miRNA panel that robustly classified patients with poor outcomes in the discovery cohorts (AUC = 0.80 and 0.88, respectively). We subsequently trained this miRNA panel in a clinical cohort (AUC = 0.83) and evaluated its performance in an independent validation cohort (AUC = 0.82) and plasma samples from the additional validation cohort (AUC = 0.78). Patients in both clinical cohorts who were classified as high-risk had significantly worse prognosis (p < 0.01). The risk-stratification model demonstrated superior performance compared to models (AUC = 0.85). We established a novel miRNA signature that could robustly predict survival outcomes in resected tissues and liquid biopsies to improve the clinical management of patients with ICC. (Keyword) Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Humans / MicroRNAs / Prognosis (Link to Publication Site) ● Publication site (DOI): 10.1038/s41416-022-01710-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35079106 ● Search Scopus @ Elsevier (PMID): 35079106 ● Search Scopus @ Elsevier (DOI): 10.1038/s41416-022-01710-z (DOI: 10.1038/s41416-022-01710-z, PubMed: 35079106)
33.	Shuhai Chen, Masaaki Nishi, Yuji Morine, Mitsuo Shimada, Takuya Tokunaga, Hideya Kashihara, Chie Takasu, Shinichiro Yamada and Yuma Wada : Epigallocatechin 3allate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancerssociated fibroblasts., International Journal of Oncology, Vol.60, No.2, 2022. (Summary) In recent times, researchers working on tumor metabolism have paid increasing attention to the tumor microenvironment. Emerging evidence has confirmed that epigenetic modifications of cancerssociated fibroblasts (CAFs) alters the characteristics of glucose metabolism to achieve a symbiotic relationship with the cancer cells. Epigallocatechin 3allate (EGCG) exerts antiumor effects via a variety of mechanisms, although the underlying mechanism that accounts for the effects of EGCG on glucose metabolic alterations of CAFs have yet to be elucidated. In the present study, through coulture with colorectal cancer (CRC) cells, human intestinal fibroblasts were transformed into CAFs, and exhibited enhanced aerobic glycolysis. Induced CAFs were able to enhance the proliferation, migration and invasion of CRC cells . EGCG treatment led to direct inhibition of the proliferation and migration of CRC cells; furthermore, EGCG treatment of CAFs suppressed their tumorromoting capabilities by inhibiting their glycolytic activity. Blocking the lactic acid efflux of CAFs with a monocarboxylate transporter 4 (MCT4) inhibitor or through silencing MCT4 could also suppress their tumorromoting capabilities, indicating that lactate fulfills an important role in the metabolic coupling that occurs between CAFs and cancer cells. Taken together, the results of the present study showed that EGCG targeting of the metabolism of tumor stromal cells provided a safe and effective strategy of antiancer therapy. (Keyword) Cancer-Associated Fibroblasts / Catechin / Colorectal Neoplasms / Humans / Neoplasms / Oxidative Coupling / Warburg Effect, Oncologic (Tokushima University Institutional Repository) ● Metadata: 117318 (Link to Publication Site) ● Publication site (DOI): 10.3892/ijo.2022.5309 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35029285 ● Search Scopus @ Elsevier (PMID): 35029285 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2022.5309 (Tokushima University Institutional Repository: 117318, DOI: 10.3892/ijo.2022.5309, PubMed: 35029285)
34.	Yuuma Wada, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hideo Baba, Masaki Mori and Ajay Goel : A transcriptomic signature that predicts cancer recurrence after hepatectomy in patients with colorectal liver metastases., European Journal of Cancer, Vol.163, 66-76, 2022. (Summary) Cancer recurrence is an important predictor of survival outcomes in patients with colorectal cancer-associated liver metastasis (CRLM), who undergo radical hepatectomy. Therefore, identification of patients with the greatest risk of recurrence is critical for developing a precision oncology strategy that might include frequent surveillance (in low-risk patients) or a more aggressive treatment approach (in high-risk patients). We performed genome-wide expression profiling, to identify and develop a transcriptomic signature for predicting recurrence in patients with CRLM. We analysed a total of 383 patients with CRLM, including 63 patients from a publicly available data set (the NCBI's Gene Expression Omnibus with accession number GSE81423). and 320 patients from whom surgical specimens were collected for independent training (n = 169) and validation (n = 151) of identified biomarkers. Using Cox's proportional hazard regression analysis, we evaluated the clinical significance of the identified gene signature by comparing its performance with several key clinical factors. We identified a six-gene panel that robustly categorised patients with recurrence in the discovery (area under the curve (AUC) = 0.90). We showed that the panel was a significant predictor of recurrence in the clinical training (AUC = 0.83) and validation cohorts (AUC = 0.81). By combining our panel with key clinical factors, we established a risk-stratification model that emerged as an independent predictor of recurrence (AUC = 0.85; univariate: hazard ratio (HR) = 4.34, 95% confidence interval (CI) = 2.71-6.93, P < 0.001; multivariate: HR = 3.40, 95% CI = 1.76-6.56, P < 0.001). The stratification model revealed recurrence prediction in 89% of high-risk group and non-recurrence in 62% of low-risk group. We established a novel transcriptomic signature that robustly predicts recurrence, which has significant implications for the management of patients with CRLM. (Keyword) Biomarkers, Tumor / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / Hepatectomy / Humans / Liver Neoplasms / Neoplasm Recurrence, Local / Precision Medicine / Prognosis / Transcriptome (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ejca.2021.12.013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35042069 ● Search Scopus @ Elsevier (PMID): 35042069 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejca.2021.12.013 (DOI: 10.1016/j.ejca.2021.12.013, PubMed: 35042069)
35.	Takeshi Matsui, Susumu Hamada-Tsutsumi, Yutaka Naito, Masanori Nojima, Etsuko Iio, Akihiro Tamori, Shoji Kubo, Tatsuya Ide, Yasuteru Kondo, Yuichiro Eguchi, Atsumasa Komori, Yuji Morine, Mitsuo Shimada, Tohru Utsunomiya, Ken Shirabe, Koichi Kimura, Yoichi Hiasa, Natthaya Chuaypen, Pisit Tangkijvanich, Aya Naiki-Ito, Satoru Takahashi, Takahiro Ochiya and Yasuhito Tanaka : Identification of microRNA-96-5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma., Hepatology Research, Vol.52, No.1, 93-104, 2022. (Summary) The microRNA (miR) clusters miR-183/96/182 and miR-217/216a/216b are significantly upregulated in nonviral hepatocellular carcinoma (NBNC-HCC). Here, we investigate the impact of each member of these clusters on the clinical outcome of NBNC-HCC and analyze the antitumor effects of miR-96-5p. The association between recurrence-free survival of 111 NBNC-HCC patients and the levels of miR-183-5p, miR-96-5p, miR-182-5p, miR-217-5p, miR-216a-5p, and miR-216b-5p in tumor and adjacent tissues was investigated. The impact of miR-96-5p on apoptosis and invasion of a hepatoma cell line, HepG2, was investigated by cell counting, Transwell assay, and flow cytometry, respectively. MicroRNA-183-5p, miR-96-5p, miR-182-5p, miR-217-5p, and miR-216b-5p were significantly upregulated in tumor tissues compared to the adjacent tissues (p = 0.0005, p = 0.0030, p = 0.0002, p = 0.0011, and p = 0.0288, respectively). By multivariate Cox regression analysis, high tumor/adjacent ratios of miR-182-5p (p = 0.007) and miR-217-5p (p = 0.008) were associated with poor recurrence-free survival. In contrast, a low tumor/adjacent ratio of miR-96-5p (p < 0.001) was associated with poor recurrence-free survival. It suggested that further upregulation of miR-96-5p in tumors might have an inhibitory effect on recurrence. Transfection of miR-96-5p mimic significantly induced apoptosis of HepG2 cells, in association with downregulation of Nucleophosmin 1 (NPM1) and a decrease of phosphorylated AKT protein. Interestingly, simultaneous knockdown of the NPM1 and AKT genes induced apoptosis. MicroRNA-96-5p also suppressed proliferation and invasion, which inhibited epithelial-to-mesenchymal transition of HCC cells. MicroRNA-96-5p as a tumor suppressor would be valuable to stratify NBNC-HCC patients at high risk of recurrence. (Link to Publication Site) ● Publication site (DOI): 10.1111/hepr.13674 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34038612 ● Search Scopus @ Elsevier (PMID): 34038612 ● Search Scopus @ Elsevier (DOI): 10.1111/hepr.13674 (DOI: 10.1111/hepr.13674, PubMed: 34038612)
36.	Chie Takasu, Emiko Kono, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto, Shoko Yamashita and Mitsuo Shimada : A "diversity and inclusion" lecture for promoting self-awareness among medical students., Surgery Today, Vol.52, No.6, 964-970, 2022. (Summary) The concept of 'diversity and inclusion' is being adopted worldwide, but it is not yet understood well in Japan. We conducted this study to evaluate the impact of a lecture aimed at increasing awareness of academic careers and the benefits of having diversity and inclusion. Two female surgeons delivered a 120-min lecture on "diversity and inclusion" to third-year medical students at Tokushima University. To assess the impact of the lecture, a questionnaire was distributed, for participants to complete anonymously before and after the lecture. Eighty-two students participated in the study (39 men, 38 women, and 5 unknown). Based on the questionnaire responses, 57.1% of the students had already perceived inequality in conduct because of gender. A comparison of pre- and post-lecture responses revealed a significant increase in confidence to succeed in their medical career (56.5% vs. 77.5%, p < 0.01). Learners were more likely to believe that gender would not become a barrier to career development (42.4% vs. 66.7%, p < 0.01). Moreover, 90.4% of the students felt positively about a career in surgery following the lecture. The lecture promoted awareness about diversity, self-awareness, and career development and motivated students to consider specializing in surgery later in their career. (Keyword) Career Choice / Female / Gender Identity / Humans / Japan / Male / Students, Medical / Surveys and Questionnaires (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-021-02424-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35001195 ● Search Scopus @ Elsevier (PMID): 35001195 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-021-02424-0 (DOI: 10.1007/s00595-021-02424-0, PubMed: 35001195)
37.	Shuhai Chen, Tetsuya Ikemoto, Takuya Tokunaga, Shohei Okikawa, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Yuji Morine and Mitsuo Shimada : Newly Generated 3D Schwann-Like Cell Spheroids From Human Adipose-Derived Stem Cells Using a Modified Protocol., Cell Transplantation, Vol.31, 9636897221093312, 2022. (Summary) Peripheral nerve injury (PNI) is a relatively frequent type of trauma that results in the suffering of many patients worldwide every year. Schwann cells (SCs) are expected to be applied in cell therapy because of their ability to promote peripheral nerve regeneration. However, the lack of clinically renewable sources of SCs hinders the application of SC-based therapies. Adipose-derived stem cells (ADSCs) have generated great interest in recent years because of their multipotency and ease of harvest, and they have already been verified to differentiate into Schwann-like cells (SLCs) in vitro. However, the efficiency of differentiation and the functions of SLCs remain unsatisfactory. We newly generated three-dimensional (3D) SLC spheroids from ADSCs using a modified protocol with human recombinant peptide (RCP) petaloid -piece. Morphological analysis, gene expression analysis by qRT-PCR, ELISA measurement of the secretion capabilities of neurotrophic factors, and neurite formation assay were performed to evaluate the functions of these 3D SLCs in vitro. Motor function recovery was measured in a sciatic nerve injury mouse model to analyze the nerve regeneration-promoting effect of 3D SLCs in vivo. The differentiation efficiency and the secretion of neurotrophic factors were enhanced in 3D SLCs compared with conventional SLCs. 3D SLCs could more effectively promote neurite growth and longer neurite extension in a neuron-like SH-SY5Y model. Additionally, 3D SLCs had a better therapeutic effect on nerve regeneration after transplantation into the sciatic nerve injury mouse model. These findings demonstrated that the potential of ADSC-derived SLCs to promote nerve regeneration could be significantly increased using our modified differentiation protocol and by assembling cells into a 3D sphere conformation. Therefore, these cells have great potential and can be used in the clinical treatment of PNI. (Keyword) Adipocytes / Adipose Tissue / Animals / Humans / Mice / Nerve Growth Factors / Peripheral Nerve Injuries / Schwann Cells / Stem Cells (Tokushima University Institutional Repository) ● Metadata: 117435 (Link to Publication Site) ● Publication site (DOI): 10.1177/09636897221093312 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35469470 ● Search Scopus @ Elsevier (PMID): 35469470 ● Search Scopus @ Elsevier (DOI): 10.1177/09636897221093312 (Tokushima University Institutional Repository: 117435, DOI: 10.1177/09636897221093312, PubMed: 35469470)
38.	Yuuma Wada, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Zhongxu Zhu, Xin Wang, Ane Etxart, Yangsoon Park, Luis Bujanda, In Ja Park and Ajay Goel : Circulating miRNA Signature Predicts Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer., JCO Precision Oncology, Vol.5, 2021. (Summary) Patients with locally advanced rectal cancer (LARC) are recommended to receive preoperative chemoradiotherapy (PCRT) followed by surgery. Response to PCRT varies widely: 60%-70% of patients with LARC do not derive therapeutic benefit from PCRT, whereas 15%-20% of patients achieve pathologic complete response (pCR). We sought to develop a liquid biopsy assay for identifying response to PCRT in patients with LARC. We analyzed two genome-wide microRNA (miRNA) expression profiling data sets from tumor tissue samples for discovery (GSE68204) and validation (GSE29298). We prioritized biomarkers in pretreatment plasma specimens from clinical training (n = 41; 15 responders and 26 nonresponders) and validation (n = 65; 29 responders and 36 nonresponders) cohorts of patients with LARC. We developed an integrated miRNA panel and established a risk assessment model, which was combined with the miRNA panel and carcinoembryonic antigen levels. Our comprehensive discovery effort identified an 8-miRNA panel that robustly predicted response to PCRT, with an excellent accuracy in the discovery (area under the curve [AUC] = 0.95) and validation (AUC = 0.92) cohorts. We successfully established a circulating miRNA panel with remarkable diagnostic accuracy in the clinical training (AUC = 0.82) and validation (AUC = 0.81) cohorts. Moreover, the predictive accuracy of the panel was significantly superior to conventional clinical factors in both cohorts ( < .01) and the risk assessment model was superior (AUC = 0.83). Finally, we applied our model to detect patients with pathologic complete response and showed that it was dramatically superior to currently used pathologic features (AUC = 0.92). Our novel risk assessment signature for predicting response to PCRT has a potential for clinical translation as a liquid biopsy assay in patients with LARC. (Keyword) Chemoradiotherapy / Circulating MicroRNA / Humans / Liquid Biopsy / MicroRNAs / Rectal Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1200/PO.21.00015 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34913022 ● Search Scopus @ Elsevier (PMID): 34913022 ● Search Scopus @ Elsevier (DOI): 10.1200/PO.21.00015 (DOI: 10.1200/PO.21.00015, PubMed: 34913022)
39.	Chie Takasu, Shoko Yamashita, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : The role of the immunoescape in colorectal cancer liver metastasis., PLoS ONE, Vol.16, No.11, e0259940, 2021. (Summary) The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study investigated the effects of immune molecules on the prognosis of CRLM. We enrolled 71 patients with CRLM who underwent curative resection for CRC. We used immunohistochemistry to analyze the expression of PD-1, PD-L1, indoleamine-pyrrole 2,3-dioxygenase (IDO), and CD163 (a marker of tumor-associated macrophages [TAMs]) in metastatic tumors. The immune molecules PD-1, PD-L1, IDO, and TAMs were expressed in 32.3%, 47.8%, 45.0%, and 47.9% of metastatic CRC samples, respectively. The 5-year overall survival rates associated with immune molecule-positive groups were significantly better than in the negative groups (PD-1: 87.7% vs 53.2%, p = 0.023; PD-L1: 82.4% vs 42.3%, p = 0.007; IDO: 80.7% vs 43.5%, p = 0.007; TAMs: 82.6% vs 48.0%, p = 0.005). Multivariate analysis revealed PD-1 expression (p = 0.032, hazard ratio: 0.19), IDO expression (p = 0.049, hazard ratio: 0.37), and tumor differentiation (p<0.001, hazard ratio: 0.02) as independent prognostic indicators. PD-1 and TAMs in metastases were associated with less aggressive features such as smaller tumors. Furthermore, TAMs positively and significantly correlated with PD-1 expression (p = 0.011), PD-L1 expression (p = 0.024), and tended to correlate with IDO expression (p = 0.078). PD-1, PD-L1, IDO, and TAMs in CRLM were associated with less aggressive features and better prognosis of patients with CRC, indicating adaptive antitumor immunity vs immune tolerance. These molecules may therefore serve as prognostic markers for CRLM. (Keyword) Adaptive Immunity / Adult / Aged / Aged, 80 and over / Antigens, CD / Antigens, Differentiation, Myelomonocytic / B7-H1 Antigen / Biomarkers, Tumor / Colonic Neoplasms / Colorectal Neoplasms / Diagnostic Tests, Routine / Female / Gene Expression / Humans / Immune Tolerance / Indoleamine-Pyrrole 2,3,-Dioxygenase / Japan / Liver / Liver Neoplasms / Male / Middle Aged / Neoplasm Metastasis / Prognosis / Programmed Cell Death 1 Receptor / Receptors, Cell Surface / Rectal Neoplasms / Transcriptome / Tumor-Associated Macrophages (Tokushima University Institutional Repository) ● Metadata: 117381 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0259940 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34797860 ● Search Scopus @ Elsevier (PMID): 34797860 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0259940 (Tokushima University Institutional Repository: 117381, DOI: 10.1371/journal.pone.0259940, PubMed: 34797860)
40.	Luping Gao, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Chie Takasu, Katsuki Miyazaki and Mitsuo Shimada : Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells., PLoS ONE, Vol.16, No.9, e0256755, 2021. (Summary) As a multiple tyrosine kinase inhibitor, sorafenib is widely used to treat hepatocellular carcinoma (HCC), but patients frequently face resistance problems. Because the mechanism controlling sorafenib-resistance is not well understood, this study focused on the connection between tumor characteristics and the Nrf2 signaling pathway in a sorafenib-resistant HCC cell line. A sorafenib-resistant HCC cell line (Huh7) was developed by increasing the dose of sorafenib in the culture medium until the target concentration was reached. Cell morphology, migration/invasion rates, and expression of stemness-related and ATP-binding cassette (ABC) transporter genes were compared between sorafenib-resistant Huh7 cells and parental Huh7 cells. Next, a small interfering RNA was used to knock down Nrf2 expression in sorafenib-resistant Huh7 cells, after which cell viability, stemness, migration, and ABC transporter gene expression were examined again. Proliferation, migration, and invasion rates of sorafenib-resistant Huh7 cells were significantly increased relative to the parental cells with or without sorafenib added to the medium. The expression levels of stemness markers and ABC transporter genes were up-regulated in sorafenib-resistant cells. After Nrf2 was knocked down in sorafenib-resistant cells, cell migration and invasion rates were reduced, and expression levels of stemness markers and ABC transporter genes were reduced. Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant HCC cells. (Keyword) ATP-Binding Cassette Transporters / Antineoplastic Agents / Carcinoma, Hepatocellular / Cell Line, Tumor / Cell Movement / Cell Proliferation / Cell Survival / Drug Resistance, Neoplasm / Gene Expression / Gene Expression Regulation, Neoplastic / Gene Knockdown Techniques / Humans / Liver Neoplasms / NF-E2-Related Factor 2 / Protein Kinase Inhibitors / Signal Transduction / Sorafenib / Transfection (Tokushima University Institutional Repository) ● Metadata: 117382 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0256755 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34473785 ● Search Scopus @ Elsevier (PMID): 34473785 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0256755 (Tokushima University Institutional Repository: 117382, DOI: 10.1371/journal.pone.0256755, PubMed: 34473785)
41.	Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 【肝内胆管癌診療の最前線∼ガイドラインReview∼】肝内胆管癌の外科治療:リンパ節郭清しない立場から, Journal of Biliary Tract & Pancreas, Vol.42, No.9, 835-842, 2021. (Summary) 肝内胆管癌に対する治療は根治的外科切除が基本であるが，リンパ節郭清の意義については一定の見解が得られていない．われわれは末梢型肝内胆管癌において，リンパ節転移陰性例では予防的郭清を行わず，陽性例でもサンプリングにとどめている．その理由として，肝のリンパ流にはさまざまな経路があり遠隔・全身のリンパ流とつながっているため，領域リンパ節郭清は単にサンプリングの意義しかないことがあげられる．実際にリンパ節転移陽性例は，リンパ節郭清を行っても予後は極めて不良であり，肝内胆管癌の予後向上のためには手術のみならず化学療法を含めた集学的治療が必要であると考えられる．(著者抄録) (Keyword) 肝内胆管(外科的療法) リンパ行性転移胆管癌(外科的療法,予後,薬物療法) 胆管腫瘍(外科的療法,予後,薬物療法) リンパ節切除アジュバント化学療法ネオアジュバント療法予防的手術生存期間ヒト
42.	Kazunori Tokuda, Yuji Morine, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Masaaki Nishi, Tetsuya Ikemoto and Mitsuo Shimada : Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metastasis., Anticancer Research, Vol.41, No.9, 4637-4644, 2021. (Summary) The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ·4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group. Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy. (Keyword) Adult / Aged / Aged, 80 and over / Colorectal Neoplasms / Drug Therapy / Female / Frailty / Hepatectomy / Humans / Liver Neoplasms / Male / Middle Aged / Multivariate Analysis / Neoplasm Recurrence, Local / Prognosis / Retrospective Studies / Survival Analysis / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.15277 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34475092 ● Search Scopus @ Elsevier (PMID): 34475092 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.15277 (DOI: 10.21873/anticanres.15277, PubMed: 34475092)
43.	Luping Gao, Yuji Morine, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Katsuki Miyazaki, Shouhei Okikawa, Chie Takasu and Mitsuo Shimada : The BAFF/NF B axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts., Cancer Science, Vol.112, No.9, 3545-3554, 2021. (Summary) The tumor microenvironment affects malignancy in hepatocellular carcinoma (HCC) cells, and cancer-associated fibroblasts (CAFs) play an important role in the microenvironment. As recent studies indicated a difference between CAFs isolated from chemoresistant and non-resistant cancer tissues, therefore we investigated the intracellular mechanism in resistant HCC co-cultured CAFs and interactions between these CAFs with cancer cells. We established a sorafenib-resistant (SR) Huh7 (human HCC) cell line, and characterized it with cytokine assays, then developed CAFs by co-culturing human hepatic stellate cells with resistant or parental Huh7 cells. The 2 types of CAFs were co-cultured with parental Huh7 cells, thereafter the cell viability of these Huh7 cells was checked under sorafenib treatment. The SR Huh7 (Huh7 ) cells expressed increased B-cell activating factor (BAFF), which promoted high expression of CAF-specific markers in Huh7 -co-cultured CAFs, showed activated BAFF, BAFF-R, and downstream of the NF B-Nrf2 pathway, and aggravated invasion, migration, and drug resistance in co-cultured Huh7 cells. When we knocked down BAFF expression in Huh7 cells, the previously increased malignancy and BAFF/NF B axis in Huh7 -co-cultured CAFs reversed, and enhanced chemoresistance in co-cultured Huh7 cells returned as well. In conclusion, the BAFF/NF B pathway was activated in CAFs co-cultured with cell-culture medium from resistant Huh7, which promoted chemoresistance, and increased the malignancy in co-cultured non-resistant Huh7 cells. This suggests that the BAFF/NF B axis in CAFs might be a potential therapeutic target in chemoresistance of HCC. (Keyword) Antineoplastic Agents / B-Cell Activating Factor / Cancer-Associated Fibroblasts / Carcinoma, Hepatocellular / Cell Communication / Cell Line, Tumor / Cell Movement / Cell Survival / Coculture Techniques / Drug Resistance, Neoplasm / Gene Knockdown Techniques / Humans / Liver Neoplasms / NF-kappa B / Signal Transduction / Sorafenib / Transfection (Tokushima University Institutional Repository) ● Metadata: 116388 (Link to Publication Site) ● Publication site (DOI): 10.1111/cas.15041 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34159680 ● Search Scopus @ Elsevier (PMID): 34159680 ● Search Scopus @ Elsevier (DOI): 10.1111/cas.15041 (Tokushima University Institutional Repository: 116388, DOI: 10.1111/cas.15041, PubMed: 34159680)
44.	Shuhai Chen, Yuji Morine, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Masaaki Nishi, Tetsuya Ikemoto and Mitsuo Shimada : Cancerssociated fibroblastnduced M2olarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor 1 pathway., International Journal of Oncology, Vol.59, No.2, 59, 2021. (Summary) Targeting the tumor stroma is an important strategy in cancer treatment. Cancerssociated fibroblasts (CAFs) and tumorssociated macrophages (TAMs) are two main components in the tumor microenvironment (TME) in hepatocellular carcinoma (HCC), which can promote tumor progression. Plasminogen activator inhibitor 1 (PAI 1) upregulation in HCC is predictive of unfavorable tumor behavior and prognosis. However, the crosstalk between cancer cells, TAMs and CAFs, and the functions of PAI 1 in HCC remain to be fully investigated. In the present study, macrophage polarization and key paracrine factors were assessed during their interactions with CAFs and cancer cells. Cell proliferation, wound healing and Transwell and Matrigel assays were used to investigate the malignant behavior of HCC cells . It was found that cancer cells and CAFs induced the M2 polarization of TAMs by upregulating the mRNA expression levels of CD163 and CD206, and downregulating IL 6 mRNA expression and secretion in the macrophages. Both TAMs derived from cancer cells and CAFs promoted HCC cell proliferation and invasion. Furthermore, PAI 1 expression was upregulated in TAMs after being stimulated with CAFonditioned medium and promoted the malignant behavior of the HCC cells by mediating epithelialesenchymal transition. CAFs were the main producer of C motif chemokine ligand 12 (CXCL12) in the TME and CXCL12 contributed to the induction of PAI 1 secretion in TAMs. In conclusion, the results of the present study suggested that CAFs promoted the M2 polarization of macrophages and induced PAI 1 secretion via CXCL12. Furthermore, it was found that PAI 1 produced by the TAMs enhanced the malignant behavior of the HCC cells. Therefore, these factors may be targets for inhibiting the crosstalk between tumor cells, CAFs and TAMs. (Keyword) Cancer-Associated Fibroblasts / Carcinoma, Hepatocellular / Cell Communication / Cell Line, Tumor / Cell Movement / Cell Polarity / Cell Proliferation / Coculture Techniques / Disease Progression / Gene Expression Regulation, Neoplastic / Humans / Liver Neoplasms / Macrophage Activation / Plasminogen Activator Inhibitor 1 / Prognosis / Signal Transduction / THP-1 Cells / Tumor Microenvironment / Tumor-Associated Macrophages / Up-Regulation (Tokushima University Institutional Repository) ● Metadata: 117319 (Link to Publication Site) ● Publication site (DOI): 10.3892/ijo.2021.5239 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34195849 ● Search Scopus @ Elsevier (PMID): 34195849 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2021.5239 (Tokushima University Institutional Repository: 117319, DOI: 10.3892/ijo.2021.5239, PubMed: 34195849)
45.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Utility of cone unit liver resection for small hepatocellular carcinoma: a propensity score matched analysis., HPB, Vol.23, No.5, 739-745, 2021. (Summary) Anatomical resection (AR) is performed widely for hepatocellular carcinoma (HCC). However, it is controversial whether typical AR, which removes the whole feeding territory of the tumor-bearing portal branch bordered by the landmark veins, is necessary. The aim of this study was to investigate the utility of small AR, so-called cone unit resection, for small HCC. Between 2007 and 2019, 372 hepatectomies were performed for HCC. Among them, 91 initial resections for small (<5 cm) solitary HCC were performed by typical AR (n = 44) or cone unit AR (n = 47). Propensity score matching was performed and clinicopathological features including prognosis were compared. At baseline, platelet count was higher, and liver function (serum albumin level) and indocyanine green retention at 15 min were better in the typical AR than cone unit AR group. There was no significant difference between the typical AR and cone unit AR group for tumor characteristics, short- and long-term outcomes. Even after propensity score matching (n = 29), the short- and long-term outcomes were also equivalent in between the two groups. There was no difference in prognosis of typical and cone unit AR. Therefore, cone unit AR is a feasible procedure for small HCC. (Keyword) Carcinoma, Hepatocellular / Hepatectomy / Humans / Liver Neoplasms / Propensity Score / Retrospective Studies (Link to Publication Site) ● Publication site (DOI): 10.1016/j.hpb.2020.09.010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32988753 ● Search Scopus @ Elsevier (PMID): 32988753 ● Search Scopus @ Elsevier (DOI): 10.1016/j.hpb.2020.09.010 (DOI: 10.1016/j.hpb.2020.09.010, PubMed: 32988753)
46.	Katsuki Miyazaki, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : Preoperative lymphocyte/C-reactive protein ratio and its correlation with CD8 tumor-infiltrating lymphocytes as a predictor of prognosis after resection of intrahepatic cholangiocarcinoma., Surgery Today, Vol.51, No.12, 1985-1995, 2021. (Summary) To clarify whether the preoperative lymphocyte/C-reactive protein (CRP) ratio (LCR) is a prognostic factor for patients with intrahepatic cholangiocarcinoma (IHCC), and investigate its mechanism via tumor-infiltrating lymphocytes. The subjects of this retrospective study were 42 patients who had undergone hepatectomy for IHCC. We divided the patients into low LCR and high LCR groups (cutoff value: 8780) and analyzed their overall survival (OS) and disease-free survival (DFS) with respect to LCR and other clinicopathological factors. We also investigated the levels of stromal tumor-infiltrating lymphocytes (TILs) and CD8 TILs in surgical specimens, and the relationship between LCR and TILs. A low LCR was identified in 21 patients and was significantly correlated with older age, a high CRP-albumin ratio, and advanced disease stage, and was a prognostic factor for OS and DFS. Multivariate analysis revealed that a low LCR was an independent prognostic factor for worse OS (HR 10.40, P = 0.0077). Although the LCR and levels of stromal TILs were not significantly related, LCR and levels of CD8 TILs were significantly related (P = 0.0297). The preoperative LCR may predict the postsurgical prognosis of patients with IHCC and reflect the CD8 TILs. (Keyword) Bile Duct Neoplasms / Biomarkers, Tumor / C-Reactive Protein / CD8-Positive T-Lymphocytes / Cholangiocarcinoma / Female / Humans / Lymphocyte Count / Lymphocytes, Tumor-Infiltrating / Male / Predictive Value of Tests / Preoperative Period / Prognosis (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-021-02295-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34009433 ● Search Scopus @ Elsevier (PMID): 34009433 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-021-02295-5 (DOI: 10.1007/s00595-021-02295-5, PubMed: 34009433)
47.	Chie Takasu, Katsuki Miyazaki, Kouzou Yoshikawa, Masaaki Nishi, Takuya Tokunaga, Hideya Kashihara, Toshiaki Yoshimoto, Hirohisa Ogawa, Yuji Morine and Mitsuo Shimada : Effect of TU-100 on Peyer's patches in a bacterial translocation rat model., Annals of Gastroenterological Surgery, Vol.5, No.5, 683-691, 2021. (Summary) Daikenchuto (TU-100), a Japanese herbal medicine, is widely used for various gastrointestinal diseases. We have previously reported that TU-100 suppresses CPT-11-induced bacterial translocation (BT) by maintaining the diversity of the microbiome. In this study we show that TU-100 modulates the immune response during BT by inducing PD-1 expression in Peyer's patches. Eighteen male Wistar rats were divided into four groups: a control group; a control + TU-100 group, given TU-100 1000 mg/kg orally for 5 d; a BT group, given CPT-11 250 mg/kg intra-peritoneal for 2 d; and a TU-100 group, given TU-100 1000 mg/kg orally for 5 d with CPT-11 250 mg/kg intra-peritoneal on days 4 and 5. The size of Peyer's patch was significantly bigger in the BT group compared to the control group (9.0 104 m vs 29.4 104 m, < .05), but improved in the TU-100 group (15.4 104 m, < .005). TU-100 significantly induced PD-1 expression in Peyer's patch compared to the control group and the BT group (control vs BT vs TU-100 = 4.3 4.9 vs 5.1 10.3 vs 17.9 17.8). The CD4 cells were increased in the BT group ( < .05) compared to the control group but decreased in the TU-100 group. The Foxp3 cells were increased in the BT group compared to the control group ( < .05), and further increased in the TU-100 group compared to the BT group. CPT-11 significantly increased TLR4, NF- , TNF- mRNA expressions in the BT group. TU-100 cotreatment significantly reversed these mRNA expressions. TU-100 may have a protective effect against BT through PD-1 expression in Peyer's patch. (Tokushima University Institutional Repository) ● Metadata: 117275 (Link to Publication Site) ● Publication site (DOI): 10.1002/ags3.12460 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34585053 ● Search Scopus @ Elsevier (PMID): 34585053 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12460 (Tokushima University Institutional Repository: 117275, DOI: 10.1002/ags3.12460, PubMed: 34585053)
48.	Yuuma Wada, Mitsuo Shimada, Tatsuro Murano, Hiroyuki Takamaru, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Francesc Balaguer, Luis Bujanda, Maria Pellise, Ken Kato, Yutaka Saito, Hiroaki Ikematsu and Ajay Goel : A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer., Gastroenterology, Vol.161, No.1, 151-162.e1, 2021. (Summary) We recently reported use of tissue-based transcriptomic biomarkers (microRNA [miRNA] or messenger RNA [mRNA]) for identification of lymph node metastasis (LNM) in patients with invasive submucosal colorectal cancers (T1 CRC). In this study, we translated our tissue-based biomarkers into a blood-based liquid biopsy assay for noninvasive detection of LNM in patients with high-risk T1 CRC. We analyzed 330 specimens from patients with high-risk T1 CRC, which included 188 serum samples from 2 clinical cohorts-a training cohort (N = 46) and a validation cohort (N = 142)-and matched formalin-fixed paraffin-embedded samples (N = 142). We performed quantitative reverse-transcription polymerase chain reaction, followed by logistic regression analysis, to develop an integrated transcriptomic panel and establish a risk-stratification model combined with clinical risk factors. We used comprehensive expression profiling of a training cohort of LNM-positive and LMN-negative serum specimens to identify an optimized transcriptomic panel of 4 miRNAs (miR-181b, miR-193b, miR-195, and miR-411) and 5 mRNAs (AMT, forkhead box A1 [FOXA1], polymeric immunoglobulin receptor [PIGR], matrix metalloproteinase 1 [MMP1], and matrix metalloproteinase 9 [MMP9]), which robustly identified patients with LNM (area under the curve [AUC], 0.86; 95% confidence interval [CI], 0.72-0.94). We validated panel performance in an independent validation cohort (AUC, 0.82; 95% CI, 0.74-0.88). Our risk-stratification model was more accurate than the panel and an independent predictor for identification of LNM (AUC, 0.90; univariate: odds ratio [OR], 37.17; 95% CI, 4.48-308.35; P < .001; multivariate: OR, 17.28; 95% CI, 1.82-164.07; P = .013). The model limited potential overtreatment to only 18% of all patients, which is dramatically superior to pathologic features that are currently used (92%). A novel risk-stratification model for noninvasive identification of T1 CRC has the potential to avoid unnecessary operations for patients classified as high-risk by conventional risk-classification criteria. (Keyword) Adult / Aged / Aged, 80 and over / Biomarkers, Tumor / Colorectal Neoplasms / Decision Support Techniques / Feasibility Studies / Female / Gene Expression Profiling / Hepatocyte Nuclear Factor 3-alpha / Humans / Liquid Biopsy / Lymph Nodes / Lymphatic Metastasis / Male / Matrix Metalloproteinase 1 / Matrix Metalloproteinase 9 / MicroRNAs / Middle Aged / Neoplasm Staging / Nomograms / Predictive Value of Tests / RNA, Messenger / Receptors, Polymeric Immunoglobulin / Reproducibility of Results / Retrospective Studies / Risk Assessment / Risk Factors / Transcriptome / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.1053/j.gastro.2021.03.062 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33819484 ● Search Scopus @ Elsevier (PMID): 33819484 ● Search Scopus @ Elsevier (DOI): 10.1053/j.gastro.2021.03.062 (DOI: 10.1053/j.gastro.2021.03.062, PubMed: 33819484)
49.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki, Takuya Tokunaga and Masaaki Nishi : Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma., World Journal of Surgical Oncology, Vol.19, No.1, 94, 2021. (Summary) Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. One hundred and twenty patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma were enrolled. Frailty was defined as a clinical frailty scale score ·4. Patients were divided into frailty (n = 29) and non-frailty (n=91) groups, and clinicopathological factors were compared between the two groups. The frailty group showed an older age, lower serum albumin concentration, lower prognostic nutritional index, larger tumor diameter, and higher rate of lymph node metastasis than the non-frailty group (p < 0.05). Neutrophil-lymphocyte ratio and modified Glasgow prognostic score tended to be higher in the frailty group. Cancer-specific and disease-free survival rates were significantly poor in the frailty group (p < 0.05). With a multivariate analysis, frailty was an independent prognostic factor of cancer-specific survival. Frailty can predict the prognosis of patients with pancreatic ductal adenocarcinoma who undergo pancreatic resection. (Keyword) Aged / Carcinoma, Pancreatic Ductal / Frailty / Humans / Pancreatectomy / Pancreatic Neoplasms / Prognosis (Tokushima University Institutional Repository) ● Metadata: 116675 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12957-021-02205-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33781262 ● Search Scopus @ Elsevier (PMID): 33781262 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-021-02205-6 (Tokushima University Institutional Repository: 116675, DOI: 10.1186/s12957-021-02205-6, PubMed: 33781262)
50.	Yuuma Wada, Mitsuo Shimada, Kensuke Yamamura, Takeo Toshima, Jasjit K. Banwait, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hideo Baba, Masaki Morishima and Ajay Goel : A Transcriptomic Signature for Risk-Stratification and Recurrence Prediction in Intrahepatic Cholangiocarcinoma., Hepatology, Vol.74, No.3, 1371-1383, 2021. (Summary) Tumor recurrence is frequent even in intrahepatic cholangiocarcinoma (ICC), and improved strategies are needed to identify patients at highest risk for such recurrence. We performed genome-wide expression profile analyses to discover and validate a gene signature associated with recurrence in patients with ICC. For biomarker discovery, we analyzed genome-wide transcriptomic profiling in ICC tumors from two public data sets: The Cancer Genome Atlas (n = 27) and GSE107943 (n = 28). We identified an eight-gene panel (BIRC5 [baculoviral IAP repeat containing 5], CDC20 [cell division cycle 20], CDH2 [cadherin 2], CENPW [centromere protein W], JPH1 [junctophilin 1], MAD2L1 [mitotic arrest deficient 2 like 1], NEIL3 [Nei like DNA glycosylase 3], and POC1A [POC1 centriolar protein A]) that robustly identified patients with recurrence in the discovery (AUC = 0.92) and in silico validation cohorts (AUC = 0.91). We next analyzed 241 specimens from patients with ICC (training cohort, n = 64; validation cohort, n = 177), followed by Cox proportional hazard regression analysis, to develop an integrated transcriptomic panel and establish a risk-stratification model for recurrence in ICC. We subsequently trained this transcriptomic panel in a clinical cohort (AUC = 0.89; 95% confidence interval [CI] = 0.79-0.95), followed by evaluating its performance in an independent validation cohort (AUC = 0.86; 95% CI = 0.80-0.90). By combining our transcriptomic panel with various clinicopathologic features, we established a risk-stratification model that was significantly superior for the identification of recurrence (AUC = 0.89; univariate HR = 6.08, 95% CI = 3.55-10.41, P < 0.01; and multivariate HR = 3.49, 95% CI = 1.81-6.71, P < 0.01). The risk-stratification model identified potential recurrence in 85% of high-risk patients and nonrecurrence in 76% of low-risk patients, which is dramatically superior to currently used pathological features. We report a transcriptomic signature for risk-stratification and recurrence prediction that is superior to currently used clinicopathological features in patients with ICC. (Link to Publication Site) ● Publication site (DOI): 10.1002/hep.31803 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33725402 ● Search Scopus @ Elsevier (PMID): 33725402 ● Search Scopus @ Elsevier (DOI): 10.1002/hep.31803 (DOI: 10.1002/hep.31803, PubMed: 33725402)
51.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : 【肝胆膵外科における再切除と再手術-最新の治療戦略】肝細胞癌切除後再発に対する再肝切除適応と治療成績, Operation, Vol.75, No.3, 249-256, 2021. (Keyword) 肝細胞癌(外科的療法,予後) 肝切除再手術術後合併症(外科的療法) 腫瘍再発腹腔鏡法癒着(病因,外科的療法) 診療ガイドライン治療成績ヒト (Link to Publication Site) ● Publication site (DOI): 10.18888/op.0000002091 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.18888/op.0000002091 (DOI: 10.18888/op.0000002091)
52.	Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Current status of hepatocyte-like cell therapy from stem cells., Surgery Today, Vol.51, No.3, 340-349, 2021. (Summary) Organ liver transplantation and hepatocyte transplantation are not performed to their full potential because of donor shortage, which could be resolved by identifying new donor sources for the development of hepatocyte-like cells (HLCs). HLCs have been differentiated from some stem cell sources as alternative primary hepatocytes throughout the world; however, the currently available techniques cannot differentiate HLCs to the level of normal adult primary hepatocytes. The outstanding questions are as follows: which stem cells are the best cell sources? which protocol is the best way to differentiate them into HLCs? what is the definition of differentiated HLCs? how can we enforce the function of HLCs? what is the difference between HLCs and primary hepatocytes? what are the problems with HLC transplantation? This review summarizes the current status of HLCs, focusing on stem cell sources, the differentiation protocol for HLCs, the general characterization of HLCs, the generation of more functional HLCs, comparison with primary hepatocytes, and HLCs in cell-transplantation-based liver regeneration. (Keyword) Bone Morphogenetic Proteins / Cell Differentiation / Cell- and Tissue-Based Therapy / Cells, Cultured / Coculture Techniques / Cytological Techniques / Fibroblast Growth Factors / Hepatocyte Nuclear Factor 4 / Hepatocytes / Homeodomain Proteins / Humans / Liver Diseases / Liver Regeneration / SOXF Transcription Factors / Stem Cells / Transcription Factors (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-020-02092-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32754843 ● Search Scopus @ Elsevier (PMID): 32754843 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-020-02092-6 (DOI: 10.1007/s00595-020-02092-6, PubMed: 32754843)
53.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : Preoperative prognostic nutritional index predicts short- and long-term outcomes after liver resection in patients with hepatocellular carcinoma., Oncology Letters, Vol.21, No.2, 153, 2021. (Summary) The prognostic nutritional index (PNI) is one of the immune parameters calculated on the basis of the serum albumin and the total lymphocyte count. The aim of the present study was to investigate the prognostic significance of the PNI for short- and long-term outcomes after liver resection for patients with hepatocellular carcinoma (HCC). Data from 162 surgically treated patients with HCC (without any previous treatment) were retrospectively analyzed. The cutoff value of preoperative PNI was 45.0, which was calculated by a receiver operating characteristic curve for predicting the recurrence of HCC after liver resection. Patients were divided into low (n=86) and high (n=76) PNI groups. In short-term outcomes, patients in the low PNI group were more likely to experience postoperative complications compared with those in the high PNI group. The 5-year disease-free survival (DFS) rate in the low PNI group was significantly lower compared with that in the high PNI group (20.5% vs. 48.7%). In the multivariate analysis, a low PNI was an independent prognostic factor for DFS (HR, 1.65; 95% CI, 1.00-2.71). In conclusion, the preoperative PNI may be a prognostic factor for evaluating short- and long-term outcomes after liver resection in patients with HCC. (Link to Publication Site) ● Publication site (DOI): 10.3892/ol.2020.12414 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33552271 ● Summary page in Scopus @ Elsevier: 2-s2.0-85099380892 (DOI: 10.3892/ol.2020.12414, PubMed: 33552271, Elsevier: Scopus)
54.	Kazunori Tokuda, Yuji Morine, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Masaaki Nishi, Takuya Tokunaga, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma., Oncotarget, Vol.12, No.4, 333-343, 2021. (Summary) Cancer-tumor associated macrophage (TAM)-cancer associated fibroblast (CAF) interactions are an important factor in the tumor microenvironment of hepatocellular carcinoma. Hepatic stellate cells (HSCs) were cultured with cancer cell-conditioned medium (Ca.-CM), TAM-CM and CAF-CM, and the expression of CAF markers were evaluated by RT-PCR. Whether HSCs cultured with Ca.-CM, TAM-CM and CAF-CM contributed to the enhanced malignancy of cancer cells was examined using proliferation, invasion and migration assays. Furthermore, the differences between these three types of CM were evaluated using cytokine arrays. HSCs cultured with Ca.-CM, TAM-CM and CAF-CM showed significantly increased mRNA expression of SMA, FAP and IL-6. All HSCs cultured with each CM exhibited significantly increased proliferation, invasion and migration of cancer cells. The osteopontin concentration was significantly higher in HSCs cultured with TAM-CM than the other CAF-CMs. Osteopontin inhibition significantly reduced osteopontin secretion from HSCs cultured with TAM-CM and suppressed the proliferation and invasion of cancer cells enhanced by HSCs cultured with TAM-CM. We observed enhanced osteopontin secretion from TAMs, and this increased osteopontin further promoted osteopontin secretion from HSCs cultured with TAM-CM, leading to increased malignancy. For the first time, we demonstrated the importance of cancer-TAM-CAF interactions via osteopontin in hepatocellular carcinoma. (Tokushima University Institutional Repository) ● Metadata: 116612 (Link to Publication Site) ● Publication site (DOI): 10.18632/oncotarget.27881 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33659044 ● Search Scopus @ Elsevier (PMID): 33659044 ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.27881 (Tokushima University Institutional Repository: 116612, DOI: 10.18632/oncotarget.27881, PubMed: 33659044)
55.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : Significance of Frailty in Prognosis After Hepatectomy for Elderly Patients with Hepatocellular Carcinoma., Annals of Surgical Oncology, Vol.28, No.1, 439-446, 2021. (Summary) The concept of frailty becomes important for patients who undergo surgery in this recent aging society. The aim of this study is to investigate the frailty as a prognostic factor in elderly patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. A total of 92 patients over 75 years old who underwent hepatectomy were enrolled in this study. Frailty was defined as clinical frailty scale (CFS) 4. Patients were divided into two groups, i.e., frailty group (n = 21) and no-frailty group (n = 71), and clinicopathological features were compared between them. The frailty group showed significant higher PIVKA-II level and larger tumor diameter (p < 0.05). CRP level and modified Glasgow prognostic score were significantly higher in the frailty group (p < 0.05). The frailty group showed higher rate of postoperative complications of Clavien-Dindo III (p = 0.06) and longer postoperative stay (p = 0.08). Cancer-specific, overall, and disease-free survival rates were significantly worse in the frailty group (p < 0.05). Frailty was detected as an independent prognostic factor on multivariate analysis of cancer-specific survival. Frailty can estimate the prognosis of HCC patients who underwent hepatectomy. (Keyword) Aged / Carcinoma, Hepatocellular / Frail Elderly / Frailty / Hepatectomy / Humans / Liver Neoplasms / Neoplasm Recurrence, Local / Prognosis (Link to Publication Site) ● Publication site (DOI): 10.1245/s10434-020-08742-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32562115 ● Search Scopus @ Elsevier (PMID): 32562115 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-020-08742-w (DOI: 10.1245/s10434-020-08742-w, PubMed: 32562115)
56.	Hiroki Mori, Yuji Morine, Kazuaki Mawatari, Ayumi Chiba, Shin-ichiro Yamada, Yu Saitou, Hiroki Ishibashi, Akira Takahashi and Mitsuo Shimada : Bile Metabolites and Risk of Carcinogenesis in Patients With Pancreaticobiliary Maljunction: A Pilot Study., Anticancer Research, Vol.41, No.1, 327-334, 2021. (Summary) Pancreaticobiliary maljunction (PBM), a disease with reflux of pancreatic and bile juice in the pancreaticobiliary tract, is a high-risk factor for biliary tract cancer. The aim of this study was to investigate the mechanism of carcinogenesis in PBM using a metabolomics analysis of bile sampled during surgery. Three patients with PBM without biliary tract cancer, four patients with extrahepatic bile duct cancer (EHBC), and three controls with benign disease were enrolled. Metabolomics analysis of bile samples was performed using capillary electrophoresis-mass spectrometry and liquid chromatography-mass spectrometry to discriminate the amino acid and lipidomic profiles. The principal component analysis in the capillary electrophoresis-mass spectrometry and liquid chromatography-mass spectrometry revealed similar metabolites in patients with PBM and those with EHBC; furthermore, there was a clear difference between patients with PBM or EHBC compared to controls. The amino acid profiles revealed the following 20 potential carcinogenic candidates for PBM: isoleucine, phenylalanine, tyrosine, leucine, tryptophan, arginine, lysine, valine, asparagine, methionine, aspartic acid, serine, threonine, histidine, glutamine, alanine, proline, glutamic acid, and pyruvic acid. The lipidomic profiles revealed the following 11 carcinogenic candidates: lysophosphatidylcholine, lysophosphatidylethanolamine, phosphatidyl glycerol, lysophosphatidyl glycerol, triacylglycerol, diacylglycerol, ceramide, sphyngomyeline, fatty acid, hyperforin, and vitamin D. Among these characteristic metabolites, the branched-chain amino acids, methionine and lysophosphatidylcholine are known to be related to carcinogenesis. The bile metabolites were extremely similar in patients with PBM and those with EHBC. Furthermore, amino acid and lipid metabolism was markedly different in patients with PBM or EHBC compared to healthy controls. (Keyword) Bile / Bile Duct Neoplasms / Cell Transformation, Neoplastic / Chromatography, Liquid / Disease Susceptibility / Electrophoresis, Capillary / Female / Humans / Male / Mass Spectrometry / Metabolomics / Pancreaticobiliary Maljunction / Pilot Projects / Risk Assessment / Risk Factors (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.14779 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33419827 ● Search Scopus @ Elsevier (PMID): 33419827 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.14779 (DOI: 10.21873/anticanres.14779, PubMed: 33419827)
57.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada and Mitsuo Shimada : Regeneration of caudate lobe after living donor liver transplantation : Comparison with a surrogate model of left lobe graft., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 330-333, 2021. (Summary) Background : The aim of this study is to clarify the regeneration of the CL (caudate lobe) without any reconstructions of short hepatic veins (SHVr) after LDLT (living donor liver transplantation) and compare the regeneration of the CL after right hepatectomy (Rt. Hx), as the surrogate model of extended left lobe graft (Ex LLG) with complete SHVr. Methods : Eleven Ex LLGs with CL were included in this study. SHVr was not performed in all cases. The volumetry was performed before, one month and six months after LDLT. Seven patients who underwent Rt. Hx were also included in this study as the surrogate model. Results : In Ex LLGs with CL, the regeneration rate of the large CL (> 30 ml) was worse than that of small CL (< 30 ml). In the surrogate model, the regeneration rate of the CL was not worse than other segments. However, the regeneration rate of the large CL was also worse than that of small CL even in the presence of complete SHVr. Conclusions : The regeneration of the large CL was worse than that of the small CL regardless of the presence or absence of SHVr, indicating that SHVr in Ex LLG with CL might not be necessary. J. Med. Invest. 68 : 330-333, August, 2021. (Keyword) Hepatectomy / Hepatic Veins / Humans / Liver / Liver Transplantation / Living Donors (Tokushima University Institutional Repository) ● Metadata: 116533 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.330 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759154 ● Search Scopus @ Elsevier (PMID): 34759154 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.330 (Tokushima University Institutional Repository: 116533, DOI: 10.2152/jmi.68.330, PubMed: 34759154)
58.	Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : Value of the CRP-albumin ratio in patients with resectable pancreatic cancer., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 244-255, 2021. (Summary) Background : The C-reactive protein (CRP)-albumin ratio (CAR) was reported as a prognostic factor of resectable hepatocellular carcinoma. The aim of this study was to analyse the significance of CAR in resectable pancreatic cancer. Patients and Methods : 163 patients with curative resection for pancreatic cancer were enrolled in this retrospective study. Cases of non-curative resection were excluded. The CAR was calculated with the preoperative plasma CRP and albumin values, with a cut-off value of 0.06, as calculated in a previous report. Results : Patients in the low CAR group had significantly better overall survival (OS) and disease-free survival (DFS) compared with the high CAR group (P < 0.05). On multivariate analysis, for high CAR, CA19-9 > 300 U /l and receipt of adjuvant chemotherapy were independent risk factors for OS and DFS. High CAR was significantly associated with advanced T stage. Conclusion : The CAR might be a prognostic factor for patients with resectable pancreatic cancer. J. Med. Invest. 68 : 244-248, August, 2021. (Keyword) Albumins / C-Reactive Protein / Humans / Pancreatic Neoplasms / Prognosis / Retrospective Studies (Tokushima University Institutional Repository) ● Metadata: 116489 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.244 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759138 ● Search Scopus @ Elsevier (PMID): 34759138 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.244 (Tokushima University Institutional Repository: 116489, DOI: 10.2152/jmi.68.244, PubMed: 34759138)
59.	Shuhai Chen, Tetsuya Ikemoto, Takuya Tokunaga, Shohei Okikawa, Katsuki Miyazaki, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : Effective in vitro differentiation of adipose-derived stem cells into Schwann-like cells with folic acid supplementation., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 347-353, 2021. (Summary) Peripheral nerve injury (PNI) after pelvic surgery is a common issue with a significant impact on patients. Autologous nerve grafting is the gold standard treatment for PNI, but this technique cannot be applied to fine nerve fibers in the pelvis. Schwann-like cell (SLC) differentiation is a novel therapeutic strategy for this clinical condition. However, the efficiency of SLC differentiation remains unsatisfactory. We modified an SLC differentiation protocol using adipose-derived stem cells (ADSCs) and folic acid. Morphology, gene expression and secretion of neurotrophic factors were examined to assess the differentiation quality and phenotypic characteristics. Our new modified protocol effectively induced a Schwann cell (SC) phenotype in ADSCs as assessed by morphology and expression of SC markers [S100 calcium-binding protein B (S100B), P < 0.01 ; p75 neurotrophic receptor (p75NTR), P < 0.05]. SLCs produced by the new protocol displayed a repair phenotype with decreased expression of ERBB2 and early growth response protein 2 (EGR2) /ROX20 (P < 0.01). Furthermore, our new protocol enhanced both mRNA expression and secretion of nerve growth factors by SLCs (P < 0.01). This protocol enhanced the SC characteristics and functions of ADSC-derived SLCs. This promising protocol requires further research and may contribute to SC-based nerve regeneration. J. Med. Invest. 68 : 347-353, August, 2021. (Keyword) Adipose Tissue / Cell Differentiation / Cells, Cultured / Dietary Supplements / Folic Acid / Humans / Stem Cells (Tokushima University Institutional Repository) ● Metadata: 116542 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.347 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759157 ● Search Scopus @ Elsevier (PMID): 34759157 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.347 (Tokushima University Institutional Repository: 116542, DOI: 10.2152/jmi.68.347, PubMed: 34759157)
60.	Yuji Morine, Toru Utsunomiya, Yu Saitou, Shin-ichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Akihiro Kitagawa, Yuta Kobayashi, Seiichiro Takao, Keisuke Kosai, Koshi Mimori, Yasuhito Tanaka and Mitsuo Shimada : Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma., Oncotarget, Vol.11, No.52, 4803-4812, 2020. (Summary) Genome-wide analysis is widely applied to detect molecular alterations during oncogenesis and tumor progression. We analyzed DNA methylation profiles of hepatocellular carcinoma (HCC), and investigated the clinical role of most heypermethylated of tumor, encodes T-box 15 (TBX15), which was originally involved in mesodermal differentiation. We conducted a genome-wide analysis of DNA methylation of tumor and non-tumor tissue of 15 patients with HCC, and revealed was the most hypermethylated gene of tumor (Beta-value in tumor tissue = 0.52 compared with non-tumor tissue). Another validation set, which comprised 58 HCC with radical resection, was analyzed to investigate the relationships between tumor phenotype and mRNA expression. mRNA levels in tumor tissues were significantly lower compared with those of nontumor tissues ( < 0.0001). When we assigned a cutoff value = 0.5-fold, the overall survival 5-year survival rates of the low-expression group ( = 17) were significantly shorter compared with those of the high-expression group ( = 41) (43.3% vs. 86.2%, = 0.001). Multivariate analysis identified low expression as an independent prognostic factor for overall and disease-free survival. Therefore, genome-wide DNA methylation profiling indicates that hypermethylation and reduced expression of in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC. (Tokushima University Institutional Repository) ● Metadata: 116613 (Link to Publication Site) ● Publication site (DOI): 10.18632/oncotarget.27852 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33447348 ● Search Scopus @ Elsevier (PMID): 33447348 ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.27852 (Tokushima University Institutional Repository: 116613, DOI: 10.18632/oncotarget.27852, PubMed: 33447348)
61.	Yuuma Wada, Kazunori Tokuda, Yuji Morine, Shohei Okikawa, Shoko Yamashita, Tetsuya Ikemoto, Satoru Imura, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment., Oncotarget, Vol.11, No.49, 4593-4604, 2020. (Summary) The tumor microenvironment is involved in acquiring tumor malignancies of colorectal liver metastasis (CRLM). We have reported that TU-100 (Daikenchuto) suppresses hepatic stellate cell (HSC) activation in obstructive jaundice. In this study, we report new findings as the direct and indirect inhibitory effects of TU-100 on cancer cell growth through the suppression of HSC activation. The HSCs (LX2) were cultured in colon cancer cells (HCT116 and HT29)-conditioned medium (CM) with or without TU-100 treatment (90, 270, 900 g/ml). Activated HSCs (aHSCs) were detected by -SMA and IL-6 mRNA expressions and cytokine arrays of HSC's culture supernatants. Cancer cell growth was analyzed for proliferation and migration ability, compared with TU-100 treatment. To investigate the direct anti-tumor effect of TU-100, cancer cells were cultured in the presence of aHSC-CM and TU-100 (90, 270, 900) or aHSC-CM alone, and assessed autophagosomes, conversion to LC3-II protein, and Beclin-1 mRNA expression. Colon cancer-CM significantly increased -SMA and IL-6 mRNA expressions of aHSC. -SMA and IL-6 mRNA expressions of aHSC, and IL-6 secretions from aHSCs were significantly decreased with TU-100 (270, 900) treatment, compared to colon cancer-CM alone. Compared with normal culture medium, aHSC-CM led to a significantly increased cell number and modified HSC-CM (TU-100; 270, 900) significantly suppressed cancer cell growth and migration. TU-100 (900) treatment induced autophagy and significantly promoted the autophagic cell death. TU-100 inhibited colon cancer cell malignant potential by both suppressing HSC activation and inducing directly autophagy of cancer cells. (Tokushima University Institutional Repository) ● Metadata: 116616 (Link to Publication Site) ● Publication site (DOI): 10.18632/oncotarget.27835 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33346211 ● Search Scopus @ Elsevier (PMID): 33346211 ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.27835 (Tokushima University Institutional Repository: 116616, DOI: 10.18632/oncotarget.27835, PubMed: 33346211)
62.	Hitoshi Ozawa, Akiyoshi Hirayama, Futaba Shoji, Midori Maruyama, Kumi Suzuki, Hisami Yamanaka-Okumura, Hiroshi Tatano, Yuji Morine, Tomoyoshi Soga, Mitsuo Shimada and Masaru Tomita : Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis., Metabolites, Vol.10, No.11, 2020. (Summary) As the physical properties and functionality of dipeptides differ from those of amino acids, they have attracted attention in metabolomics; however, their functions in vivo have not been clarified in detail. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and its major cause is chronic hepatitis. This study was conducted to explore tumor-specific dipeptide characteristics by performing comprehensive dipeptide analysis in the tumor and surrounding nontumor tissue of patients with HCC. Dipeptides were analyzed by liquid chromatography tandem mass spectrometry and capillary electrophoresis tandem mass spectrometry. Principal component analysis using 236 detected dipeptides showed differences in the dipeptide profiles between nontumor and tumor tissues; however, no clear difference was observed in etiological comparison. In addition, the N- and C-terminal amino acid compositions of the detected dipeptides significantly differed, suggesting the substrate specificity of enzyme proteins, such as peptidase. Furthermore, hepatitis-derived HCC may show a characteristic dipeptide profile even before tumor formation. These results provide insight into HCC pathogenesis and may help identify novel biomarkers for diagnosis. (Tokushima University Institutional Repository) ● Metadata: 116600 (Link to Publication Site) ● Publication site (DOI): 10.3390/metabo10110442 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33139606 ● Search Scopus @ Elsevier (PMID): 33139606 ● Search Scopus @ Elsevier (DOI): 10.3390/metabo10110442 (Tokushima University Institutional Repository: 116600, DOI: 10.3390/metabo10110442, PubMed: 33139606)
63.	Shin-ichiro Yamada, Yuji Morine, Hiroki Ishibashi and Mitsuo Shimada : 【臨床に役立つ胆と膵の解剖学】膵・胆管合流異常の解剖と病型分類, Journal of Biliary Tract & Pancreas, Vol.41, No.11, 1085-1092, 2020. (Summary) 膵・胆管合流異常(pancreaticobiliary maljunction:PBM)は，解剖学的に膵管と胆管が十二指腸壁外で合流する先天性の形成異常であり，膵液と胆汁の相互逆流により高率な胆道発癌や膵炎をはじめとしたさまざまな病態を引き起こす．PBMの発生には，腹側膵原基と背側膵原基が癒合する以前の，下部胆管と腹側膵の異常が影響し，背側膵の関与はないと考えられている．PBMの分類においては胆管拡張の有無がとくに重要であり，拡張があるもの(先天性胆道拡張症)とないもの(胆道非拡張型)に分けられ，さらに胆管と膵管の合流形式などによってこれまでいくつかの分類が報告されている．また，共通管が6mm以上で合流部に括約筋作用が及ぶ例は膵胆管高位合流と定義され，PBMとは異なる病態として扱われる．今後の課題として，胆管拡張の定義や型分類の統一，高位合流との鑑別があげられる．(著者抄録) (Keyword) 局所解剖学分類 *膵胆管合流異常胆道拡張症病態生理ヒト
64.	Tetsuya Ikemoto, Kazunori Tokuda, Yuuma Wada, Luping Gao, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : Adipose Tissue From Type 1 Diabetes Mellitus Patients Can Be Used to Generate Insulin-Producing Cells., Pancreas, Vol.49, No.9, 1225-1231, 2020. (Summary) We aimed to determine whether responsive insulin-producing cells (IPCs) could be generated from adipose-derived stem cells (ADSCs) isolated from patients with type 1 diabetes mellitus (T1DM). We isolated ADSCs from adipose tissue of 4 patients (one patient with T1DM and 3 nondiabetic patients), who underwent surgery and differentiated them into IPCs with using a 2-step xeno-antigen free, 3-dimensional culture method. Characteristics of isolated ADSCs, in vitro cell quality, programmed cell death ligand-1 (PDL-1) expression, and transplantation into streptozotocin induced diabetic nude mice were investigated. Adipose-derived stem cells from T1DM patients and commercially obtained ADSCs showed the same surface markers; CD31CD34CD45CD90CD105CD146. Moreover, the generated IPCs at day 21 demonstrated appropriate autonomous insulin secretion (stimulation index, 3.5; standard deviation, 0.8). Nonfasting blood glucose concentrations of IPC-transplanted mice were normal at 30 days. The normalized rate of IPC-transplanted mice was significantly higher than that of the sham-operated group (P < 0.05). Insulin-producing cells generated from T1DM adipose tissue expressed high levels of PDL-1. Insulin-producing cells obtained from adipose tissue of T1DM patients are capable of secreting insulin long-term and achieve normoglycemia after transplantation. Expression of PDL-1 suggests the potential for immune circumvention. (Link to Publication Site) ● Publication site (DOI): 10.1097/MPA.0000000000001663 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32898009 ● Search Scopus @ Elsevier (PMID): 32898009 ● Search Scopus @ Elsevier (DOI): 10.1097/MPA.0000000000001663 (DOI: 10.1097/MPA.0000000000001663, PubMed: 32898009)
65.	Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Shin-ichiro Yamada and Mitsuo Shimada : HIF-1 expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis., World Journal of Surgical Oncology, Vol.18, No.1, 241, 2020. (Summary) The role of hypoxia-inducible factor-1 (HIF-1 ) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear. The aim of this study was to investigate HIF-1 expression and its association with prognosis in patients with CRLM with a focus on hepatic stellate cells (HSCs). Colon cancer cells were cultured in HSC-conditioned medium (CM), and HIF-1 expression and cell migration were analyzed. Seventy-five patients with CRLM who underwent an initial curative hepatectomy were enrolled. We examined HIF-1 expressions and patient prognosis between primary CRCs and the matched liver metastatic specimens. Activated HSCs induced HIF-1 mRNA and protein expression in colon cancer cells (p < 0.01) and promoted cell migration (p < 0.01). The positive rates of HIF-1 expression in primary CRCs and liver metastases were 68.0 and 72.0%, respectively. There were no differences in overall (OS) and disease-free survival (DFS) of HIF-1 expression in primary CRC. However, HIF-1 expression in liver metastasis correlated to poor prognosis in both OS and DFS. Furthermore, patients with HIF-1 positive expression in liver metastasis had poor prognosis. HIF-1 expression in liver metastasis determines poor prognosis of CRLM patients. HSCs might play a key role in aggressive phenotypes of tumor cells. (Keyword) Colonic Neoplasms / Colorectal Neoplasms / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / Prognosis (Tokushima University Institutional Repository) ● Metadata: 116676 (Link to Publication Site) ● Publication site (DOI): 10.1186/s12957-020-02012-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32895059 ● Search Scopus @ Elsevier (PMID): 32895059 ● Search Scopus @ Elsevier (DOI): 10.1186/s12957-020-02012-5 (Tokushima University Institutional Repository: 116676, DOI: 10.1186/s12957-020-02012-5, PubMed: 32895059)
66.	Kazunori Tokuda, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Katsuki Miyazaki, Shoko Yamashita, Shohei Okikawa, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Effectiveness of repeat surgery for recurrence after primary hepatectomy in patients with intrahepatic cholangiocarcinoma., International Journal of Clinical Oncology, Vol.25, No.12, 2083-2089, 2020. (Summary) Intrahepatic cholangiocarcinoma (IHCC) has a poor prognosis, and surgery remains the only effective treatment. However, tumor recurrence after primary hepatectomy is common. We examined the significance of repeat surgery for IHCC. We collected data for all patients with IHCC between 1992 and 2018 (n = 67) in our database. Fifty-three (79.1%) of all 67 patients experienced recurrence after primary hepatectomy and we analyzed data for those 53 recurrent patients. We divided recurrent patients into a repeat surgery group (n = 9), chemotherapy group (n = 19), and best supportive care group (n = 25). We analyzed differences in patients' clinicopathological factors, including prognosis, between the three groups. The IHCC recurrence rate after hepatectomy in our institution was 79.1%. Of the 53 patients with recurrence, nine underwent repeat surgery (17.0%). The characteristics of the patients undergoing repeat surgery was lower stage at primary hepatectomy. Recurrence sites in the repeat surgery group were liver (n = 6), lung (n = 2), and adrenal gland (n = 1), as a single nodule. The period between primary hepatectomy and recurrence was comparatively longer in the repeat surgery group, at 1.8 years. The prognosis in patients undergoing repeat surgery was significantly better compared with the other groups. Not undergoing repeat surgery (hazard ratio: 5.506; p = 0.0077) and positive lymph node metastasis (hazard ratio: 2.207; p = 0.0242) were independent poor prognostic factors. Repeat surgery should be considered in patients with IHCC with a single recurrence site and negative lymph node metastasis at primary surgery and at least more than 6 months of disease-free period after primary surgery. (Keyword) Adrenal Gland Neoplasms / Adrenalectomy / Adult / Aged / Aged, 80 and over / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Cholangiocarcinoma / Female / Hepatectomy / Humans / Liver Neoplasms / Lung Neoplasms / Lymphatic Metastasis / Male / Middle Aged / Neoplasm Recurrence, Local / Prognosis / Proportional Hazards Models / Reoperation / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-020-01775-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32869120 ● Search Scopus @ Elsevier (PMID): 32869120 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-020-01775-x (DOI: 10.1007/s10147-020-01775-x, PubMed: 32869120)
67.	Shuichi Iwahashi, AHMAD AMMAR GHAIBEH, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Jun Hirose : Predictability of postoperative recurrence on hepatocellular carcinoma through data mining method., Molecular and Clinical Oncology, Vol.13, No.5, 46, 2020. (Summary) Hepatocellular carcinoma (HCC) is a highly lethal tumor and the majority of postoperative patients experience recurrence. In the present study, we focus on the predictability of postoperative recurrence on HCC through the data mining method. In total, 323 patients with HCC who underwent hepatic resection were included in the present study, 156 of whom suffered from cancer recurrence. Clinicopathological data including prognosis were analyzed using the data mining method for the predictability of postoperative recurrence on HCC. The resulting alternating decision tree (ADT) was described using data mining method. This tree was validated using a 10-fold cross validation process. The average and standard deviation of the accuracy, sensitivity, and specificity were 69.0 8.2, 59.7 14.5 and 77.7 10.2%, respectively. The identified postoperative recurrence factors were age, viral hepatitis, stage, GOT and T-cholesterol. Data mining method could identify the factors associated at different levels of significance with postoperative recurrence of HCC. These factors could help to predict the postoperative recurrence of HCC. (Link to Publication Site) ● Publication site (DOI): 10.3892/mco.2020.2116 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32874576 ● Search Scopus @ Elsevier (PMID): 32874576 ● Search Scopus @ Elsevier (DOI): 10.3892/mco.2020.2116 (DOI: 10.3892/mco.2020.2116, PubMed: 32874576)
68.	Toshiaki Yoshimoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Katsuki Miyazaki, Yukako Takehara and Mitsuo Shimada : Impact of using a perioperative artificial endocrine pancreas in pancreatic resection., Annals of Gastroenterological Surgery, Vol.4, No.5, 591-596, 2020. (Summary) Pancreatectomy causes both hyperglycemia, secondary to surgical stress, and pancreatic diabetes, which leads to difficult-to-control postoperative blood glucose levels. We investigated whether using an artificial pancreas perioperatively to provide appropriate blood glucose control could reduce postoperative complications following pancreatectomy. We retrospectively enrolled 52 patients who underwent pancreatectomy at Tokushima University Hospital from 2015 to 2019. The most recent 26/52 patients received perioperative blood glucose control using an artificial pancreas. Postoperative blood glucose control with manual insulin injections based on a sliding scale was performed in the earlier 26 patients (controls). We compared surgical outcomes between the artificial pancreas group and the control group. There was no significant difference in patients' white blood cell or neutrophil counts, prognostic nutritional index, neutrophil-lymphocyte ratio, and C-reactive protein-to-albumin ratio on postoperative day 1; however, lymphocyte counts were higher in the artificial pancreas group. The number of serious complications of Clavien-Dindo grade >IIIa was significantly lower in the artificial pancreas group ( < .05). Using an artificial pancreas for perioperative blood glucose control in patients undergoing pancreatectomy decreased the number of serious complications through proper management of blood glucose levels without hypoglycemia, and may influence peripheral lymphocytes. (Tokushima University Institutional Repository) ● Metadata: 116476 (Link to Publication Site) ● Publication site (DOI): 10.1002/ags3.12374 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33005854 ● Search Scopus @ Elsevier (PMID): 33005854 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12374 (Tokushima University Institutional Repository: 116476, DOI: 10.1002/ags3.12374, PubMed: 33005854)
69.	Hiroki Teraoku, Yuji Morine, Naoto Uyama, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Satoru Imura, Masafumi Harada and Mitsuo Shimada : Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma., World Journal of Surgery, Vol.44, No.7, 2350-2358, 2020. (Summary) The enhancement pattern in the hepatic arterial phase (HAP) of dynamic computed tomography (CT) is reportedly a prognostic marker in patients with intrahepatic cholangiocarcinoma (IHCC). This study was performed to clarify the significance of central hypo-enhancement in the HAP in patients with mass-forming IHCC. Forty patients who had undergone initial surgical resection for mass-forming IHCC were enrolled. The dynamic CT was scanned 40 s after contrast agent injection as the HAP. A radiologist classified the patients into three groups based on the vascular pattern: the hyper-enhancement group (Hyper group), rim-enhancement group (Rim group), and hypo-enhancement group (Hypo group). The surgical specimens were immunohistochemically stained for hypoxia-inducible factor 1 (HIF-1). The correlation with clinicopathological findings and HIF-1 expression was investigated. The Hyper, Rim, and Hypo groups comprised 8, 7, and 25 patients, respectively. There were no significant correlations between the groups and clinicopathological factors. Overall survival (OS) was significantly worse in the Hypo than in the Hyper group (p = 0.03). OS was also significantly worse in the Rim +ypo group (i.e., hypo-enhancement in the central tumor) than in the Hyper group (p = 0.04). Furthermore, inclusion in the Rim +ypo group was a prognostic factor for OS (hazard ratio 6.68). High HIF-1 expression in the central part of the tumor was correlated with central hypo-enhancement (Hyper group: 25% and Rim +ypo group: 72%). Central hypo-enhancement was a prognostic factor in patients with IHCC. The high malignant potential of tumors with central hypo-enhancement might be associated with HIF-1 upregulation. (Keyword) Adult / Aged / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Biomarkers, Tumor / Cholangiocarcinoma / Contrast Media / Female / Follow-Up Studies / Hepatectomy / Hepatic Artery / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Male / Middle Aged / Multidetector Computed Tomography / Prognosis / Proportional Hazards Models / Retrospective Studies (Link to Publication Site) ● Publication site (DOI): 10.1007/s00268-020-05456-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32152739 ● Search Scopus @ Elsevier (PMID): 32152739 ● Search Scopus @ Elsevier (DOI): 10.1007/s00268-020-05456-8 (DOI: 10.1007/s00268-020-05456-8, PubMed: 32152739)
70.	Katsuki Miyazaki, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Pancreatoduodenectomy co-morbid with celiac axis compression syndrome: a report of three cases., Surgical Case Reports, Vol.6, No.1, 113, 2020. (Summary) Celiac axis compression syndrome (CACS) is a relatively rare disease. Because of the nature of the blood flow in the celiac region when a pancreatoduodenectomy (PD) is performed for CACS, the celiac region can become ischemic. The aim of this study is to report on the importance of pre-operative diagnosis of CACS in terms of the outcomes for patients post-operatively. In this study, three 3 cases of PD co-morbid with CACS are reported: one intra-operative diagnosis case and two pre-operative diagnosis cases. The one case, not diagnosed with CACS prior to the operation, had a hard post-operative course because of complication caused by ischemia of the celiac region compared with the two cases diagnosed prior to the operation, who had a good post-operative course because of pre-operative or intra-operative intervention. Post-operative complications due to CACS are preventable by pre-operative diagnosis and appropriate interventions. (Link to Publication Site) ● Publication site (DOI): 10.1186/s40792-020-00878-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32449014 ● Search Scopus @ Elsevier (PMID): 32449014 ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-020-00878-x (DOI: 10.1186/s40792-020-00878-x, PubMed: 32449014)
71.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : Prognostic prediction of apparent diffusion coefficient obtained by diffusion-weighted MRI in mass-forming intrahepatic cholangiocarcinoma., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.27, No.7, 388-395, 2020. (Summary) We evaluated apparent diffusion coefficient (ADC) of diffusion-weighted image MRI as a prognostic factor for mass-forming intrahepatic cholangiocarcinoma (IHCC). We enrolled 26 patients who had undergone hepatic resections for mass-forming-type IHCC in this study, and calculated their mean ADC, using diffusion-weighted image MRI (b: 0, 20, 800 seconds/mm ; 1.5 T MRI). Patients were divided into the ADC and the ADC groups at the median ADC value (n = 13 for both). We also immunohistochemically evaluated hypoxia-inducible factor (HIF)-1 in tumor tissue. Median age in the ADC was older (P = .03), and showed significant higher rate of scirrhous tumor (P = .02). The 5-year overall survival rate in the ADC group was significantly worse than in the ADC group (P = .04). In multivariate analysis, hilar tumor, portal vein invasion and low ADC were independent prognostic factors (P < .05). The ADC group also had a higher rate of high HIF-1 expression than the ADC group (P < .05). Representative case of ADC group showed rich stroma and high HIF-1 expression. The ADC values in MRIs can predict IHCC prognosis, and correlated with stromal density and HIF-1 expression. (Keyword) Aged / Algorithms / Bile Duct Neoplasms / Biomarkers, Tumor / Cholangiocarcinoma / Contrast Media / Diffusion Magnetic Resonance Imaging / Female / Hepatectomy / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Male / Neoplasm Invasiveness / Prognosis / Survival Rate / Tomography, X-Ray Computed (Link to Publication Site) ● Publication site (DOI): 10.1002/jhbp.732 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32162483 ● Search Scopus @ Elsevier (PMID): 32162483 ● Search Scopus @ Elsevier (DOI): 10.1002/jhbp.732 (DOI: 10.1002/jhbp.732, PubMed: 32162483)
72.	Yu Saitou, Maki Sugimoto, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada and Mitsuo Shimada : Intraoperative 3D Hologram Support With Mixed Reality Techniques in Liver Surgery., Annals of Surgery, Vol.271, No.1, e4-e7, 2020. (Summary) The aim of this study was to investigate the potential of an intraoperative 3D hologram, which was a computer graphics model liver, with mixed reality techniques in liver surgery. The merits for the application of a hologram for surgical support are: 1) no sterilized display monitor; 2) better spatial awareness; and 3) 3D images shared by all the surgeons. 3D polygon data using preoperative computed tomography data was installed into head mount displays, HoloLens (Microsoft Corporation, Redmond, WA). In a Wi-Fi-enabled operative room, several surgeons wearing HoloLens succeeded in sharing the same hologram and moving that hologram from respective operators' angles by means of easy gesture-handling without any monitors. The intraoperative hologram contributed to better imagination of tumor locations, and for determining the parenchymal dissection line in the hepatectomy for the patients with more than 20 multiple colo-rectal liver metastases. In another case, the hologram enabled a safe Gliisonean pedicle approach for hepato-cellular carcinoma with a hilar anatomical anomaly. Surgeons could easily compare the real patient's anatomy and that of the hologram just before the hepatic hilar procedure. This initial experience suggested that an intraoperative hologram with mixed reality techniques contributed to "last-minute simulation," not for "navigation." The intraoperative hologram might be a new next-generation operation-supportive tool in terms of spatial awareness, sharing, and simplicity. (Tokushima University Institutional Repository) ● Metadata: 114184 (Link to Publication Site) ● Publication site (DOI): 10.1097/SLA.0000000000003552 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31425293 ● Search Scopus @ Elsevier (PMID): 31425293 ● Search Scopus @ Elsevier (DOI): 10.1097/SLA.0000000000003552 (Tokushima University Institutional Repository: 114184, DOI: 10.1097/SLA.0000000000003552, PubMed: 31425293)
73.	Kazunori Tokuda, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki, Shoko Yamashita, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : The Fragility of Cryopreserved Insulin-producing Cells Differentiated from Adipose-tissue-derived Stem Cells., Cell Transplantation, Vol.29, 963689720954798, 2020. (Summary) The aim of our study is to determine whether insulin-producing cells (IPCs) differentiated from adipose-tissue-derived stem cells (ADSCs) can be cryopreserved. Human ADSCs were differentiated into IPCs using our two-step protocol encompassing a three-dimensional culture and xenoantigen-free method. Thereafter, IPCs were frozen using three different methods. First, IPCs were immediately frozen at -80 C (-80 C group). Second, IPCs were initially placed into a Bicell freezing container before freezing at -80 C (BICELL group). Third, a vitrification method for oocytes and embryos was used (CRYOTOP group). Cell counting kit-8 (CCK-8) assay showed that cell viability was decreased in all groups after cryopreservation ( < 0.01). Corroboratively, the amount of adenosine triphosphate was markedly decreased after cryopreservation in all groups ( < 0.01). Immunofluorescence staining showed a reduced positive staining area for insulin in all cryopreservation groups. Furthermore, 4',6-diamidino-2-phenylindole and merged immunofluorescence images showed that cryopreserved cells appeared to be randomly reduced in the -80 C group and CRYOTOP group, while only the central region was visibly reduced in the BICELL group. Using immunohistochemical staining, IPCs after cryopreservation were shown to be positive for cleaved caspase-3 antibody in all groups. Finally, insulin secretion following glucose stimulation was significantly reduced in IPCs from all groups after cryopreservation ( < 0.01). In conclusion, IPCs may be too fragile for cryopreservation with accomplished methods and further investigations for a suitable preservation method are required. (Keyword) Adenosine Triphosphate / Adipose Tissue / Caspase 3 / Cell Differentiation / Cell Shape / Cell Survival / Cryopreservation / Dithizone / Glucose / Humans / Insulin / Insulin Secretion / Insulin-Secreting Cells / Staining and Labeling / Stem Cells (Tokushima University Institutional Repository) ● Metadata: 116513 (Link to Publication Site) ● Publication site (DOI): 10.1177/0963689720954798 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32878465 ● Search Scopus @ Elsevier (PMID): 32878465 ● Search Scopus @ Elsevier (DOI): 10.1177/0963689720954798 (Tokushima University Institutional Repository: 116513, DOI: 10.1177/0963689720954798, PubMed: 32878465)
74.	Shogo Oota, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Yuuma Wada, Shoko Iwahashi, Yoshimi Bando and Mitsuo Shimada : Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1 for Intrahepatic Cholangiocarcinoma., Anticancer Research, Vol.39, No.11, 6025-6033, 2019. (Summary) Carbohydrate antigen 19-9 (CA19-9) is a poor prognostic marker in intrahepatic cholangiocarcinoma (IHCC). Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1 in IHCC. Here, we evaluated the expression and correlation of CA19-9 with HIF-1 and HDAC in IHCC. This study included 62 patients with IHCC who underwent primary hepatectomy at our department. Clinicopathological characteristics were examined. Immunohistochemical expression of HIF-1 and HDAC1 in specimens was quantitatively evaluated. Patients with high preoperative serum CA19-9 levels showed clinicopathological characteristics associated with tumour progression. High CA19-9 levels were associated with worse overall and recurrence-free survival. Univariate and multivariate analysis detected high CA19-9 levels as an independent poor prognostic factor for IHCC. Serum CA19-9 was significantly correlated with both HIF-1 and HDAC1 expression. High serum CA19-9 level is a poor prognostic factor for overall survival in IHCC and correlates with HIF-1 and HDAC1 expression. (Keyword) Aged / Bile Duct Neoplasms / Biomarkers, Tumor / CA-19-9 Antigen / Cholangiocarcinoma / female / Follow-Up Studies / Gene Expression Regulation, Neoplastic / Histone Deacetylase 1 / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / male / Neoplasm Recurrence, Local / Prognosis / Survival Rate (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.13808 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31704828 ● Search Scopus @ Elsevier (PMID): 31704828 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13808 (DOI: 10.21873/anticanres.13808, PubMed: 31704828)
75.	Yuuma Wada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : The Differences in the Characteristics of Insulin-producing Cells Using Human Adipose-tissue Derived Mesenchymal Stem Cells from Subcutaneous and Visceral Tissues., Scientific Reports, Vol.9, No.1, 13204, 2019. (Summary) The aim of this study was to investigate the characteristics of insulin producing cells (IPCs) differentiated from adipose-tissue derived stem cells (ADSCs) isolated from human subcutaneous and visceral adipose tissues and identify ADSCs suitable for differentiation into efficient and functional IPCs. Subcutaneous and visceral adipose tissues collected from four (4) patients who underwent digestive surgeries at The Tokushima University (000035546) were included in this study. The insulin secretion of the generated IPCs was investigated using surface markers by: fluorescence activated cell sorting (FACS) analysis; cytokine release; proliferation ability of ADSCs; in vitro (glucose-stimulated insulin secretion: (GSIS) test/in vivo (transplantation into streptozotocin-induced diabetic nude mice). The less fat-related inflammatory cytokines secretions were observed (P < 0.05), and the proliferation ability was higher in the subcutaneous ADSCs (P < 0.05). Insulin expression and GISI were higher in the subcutaneous IPCs (P < 0.01 and P < 0.05, respectively). The hyperglycaemic state of all mice that received IPCs from subcutaneous fat tissue converted into normo-glycaemia in thirty (30) days post-transplantation (4/4,100%). Transplanted IPCs were stained using anti-insulin and anti-human leukocyte antigen antibodies. The IPCs generated from the ADSCs freshly isolated from the human fat tissue had sufficient insulin secreting ability in vitro and in vivo. (Tokushima University Institutional Repository) ● Metadata: 114942 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-019-49701-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31519950 ● Search Scopus @ Elsevier (PMID): 31519950 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-49701-0 (Tokushima University Institutional Repository: 114942, DOI: 10.1038/s41598-019-49701-0, PubMed: 31519950)
76.	Hiroki Mori, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : Impact of Bevacizumab on Liver Damage After Massive Hepatectomy in Rats., In Vivo, Vol.33, No.5, 1469-1476, 2019. (Summary) The aim of this study was to evaluate the impact of pretreatment with bevacizumab on liver damage in a rat model of massive hepatectomy (Hx) model, as a surrogate model of massive Hx for liver metastasis from colorectal cancer. Male Wister rats (n=24) were separated into the following two groups: 90% Hx and 90% Hx plus bevacizumab group. Bevacizumab (5 mg/kg) was injected intraperitoneally 7 days before Hx. Samples of blood and remnant liver tissue were obtained 24 hours after hepatectomy and the following parameters were evaluated: Biochemical analysis; liver regeneration rate; survival rate; and real-time polymerase chain reaction for interleukin-1 beta (Il1b), tumor necrosis factor alpha (Tnfa), matrix metalloproteinase (Mmp) 2 and Mmp9 mRNA. In addition, samples of whole liver tissue were obtained immediately before Hx and real-time polymerase chain reaction was performed for X-box binding protein 1 (Xbp1), activating transcription factor 6 (Atf6), C/EBP homologous protein (Chop), glucose-regulated protein 78 (Grp78) and heat-shock protein 70 (Hsp70), as markers of endoplasmic reticulum stress response. The levels of transaminases 24 hours after Hx were significantly reduced in the group pretreated with bevacizumab compared to that not pretreated (p<0.05). The liver regeneration rate at 24 hours after Hx was significantly increased in the group pretreated with bevacizumab compared with the group which underwent Hx alone (p<0.05). The survival rate for the group pretreated with bevacizumab tended to be higher than that of the Hx-only group, 72 hours after Hx (p=0.09). The expressions of Il1b, Mmp2 and Mmp9 mRNA 24 hours after Hx in the group pretreated with bevacizumab tended to be lower than that of rats which underwent Hx alone (p=0.11, 0.09 and 0.15, respectively). The expression of Xbp1, Chop, Grp78 and Hsp70 mRNA immediately before Hx in the group pretreated with bevacizumab were significantly higher than the 90% Hx group (p<0.05). Bevacizumab pretreatment had protective effects on liver injury after massive hepatectomy in rats, apparently via the induction of the endoplasmic reticulum stress response, i.e. the so-called unfolded protein response. (Link to Publication Site) ● Publication site (DOI): 10.21873/invivo.11626 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31471394 ● Search Scopus @ Elsevier (PMID): 31471394 ● Search Scopus @ Elsevier (DOI): 10.21873/invivo.11626 (DOI: 10.21873/invivo.11626, PubMed: 31471394)
77.	Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Chie Takasu, Jun Higashijima, Satoru Imura and Mitsuo Shimada : Clinical Impact of FOLFOXIRI Aiming for Conversion Surgery in Unresectable Multiple Colorectal Liver Metastasis., Anticancer Research, Vol.39, No.9, 5089-5096, 2019. (Summary) We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the analysis. The clinical results of FOLFOXIRI with other regimens were compared. The total conversion rate of 42 unresectable CRLM was 48.1%, and conversion cases had a better prognosis. Clinicopathological characteristics of conversion cases were more frequent in FOLFOXIRI induction, liver limited disease and maximum diameter number (MDN) over 70. FOLFOXIRI achieved a higher conversion rate compared to other regimens (72.2% vs. 37.5%, p=0.0334), and significantly reduced the medication period until conversion surgery (median 5.8 courses) with a higher tumour necrotic rate. Consequently, the overall survival of conversion cases with FOLFOXIRI was better than that with other regimens (p=0.0055). FOLFOXIRI plus molecular agents might provide a higher probability of conversion surgery with a prognostic benefit. (Keyword) Antineoplastic Combined Chemotherapy Protocols / Camptothecin / Colorectal Neoplasms / Combined Modality Therapy / Conversion to Open Surgery / female / Fluorouracil / Hepatectomy / Humans / Kaplan-Meier Estimate / Leucovorin / Liver Neoplasms / male / Neoplasm Grading / Neoplasm Staging / Organoplatinum Compounds / Prognosis / Treatment Outcome / Tumor Burden (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.13703 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31519620 ● Search Scopus @ Elsevier (PMID): 31519620 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.13703 (DOI: 10.21873/anticanres.13703, PubMed: 31519620)
78.	Shoko Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Toshiaki Yoshimoto, Koichi Tsuneyama and Mitsuo Shimada : Two cases of non-mucinous cystadenomas of the pancreas with pancreatobiliary phenotype and ovarian-like stroma., Surgical Case Reports, Vol.5, No.1, 117, 2019. (Summary) Diagnosis of cystic tumor of the pancreas is based on the World Health Organization criteria that classify pancreatic cystadenomas into four types: intra-ductal papillary mucinous neoplasms, mucinous cystic neoplasms (MCNs), serous cystic neoplasms, and solid pseudo-papillary neoplasms depending on their secretion and presence of ovarian-like stroma. Recently, Albores-Saavedra identified non-mucinous cystadenomas of the pancreas with pancreato-biliary phenotype and ovarian-like stroma. This precipitated examination of the proportions of these rare tumors in patients treated at Tokushima University Hospital. Case 1 was a 40-year-old woman with a cystic tumor in the tail of the pancreas. Computed tomography (CT) revealed a diffuse and non-enhanced cystic tumor in the tail of the pancreas. This tumor was diagnosed as a simple cyst at this point. However, 2ears later, the tumor had increased in size by 3m. Thus, laparoscopic distal pancreatectomy was performed. The content of the cyst was serous. The epithelial cells were lined with a single layer of cuboidal cells and the tumor had ovarian-like stroma pathologically. The final pathological diagnosis was non-mucinous cystadenoma of the pancreas with ovarian-like stroma. In Case 2, a cystic tumor in the pancreas was found by medical examination in a woman in her sixties who presented without symptoms. CT showed a 1.5-cm cystic tumor in the tail and body of the pancreas and a septum in the cyst. Nine years later, the tumor had grown to 2.4m in diameter and had a clear septum in the cyst. This tumor was diagnosed preoperatively as MCN. Thus, laparoscopic distal pancreatectomy was performed. The cyst contained serous fluid. Microscopic examination showed no ovarian-like stroma and the epithelial cells were lined by a single layer of cuboidal cells. The final pathological diagnosis was non-mucinous cystadenoma of the pancreas with ovarian-like stroma. Accurate preoperative diagnosis of this type of pancreatic cystic tumor may be difficult, although it occurs more often than expected. Non-mucinous cystadenomas of the pancreas with ovarian-like stroma need to be considered as a differential diagnosis. (Link to Publication Site) ● Publication site (DOI): 10.1186/s40792-019-0673-y (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31338648 ● Search Scopus @ Elsevier (PMID): 31338648 ● Search Scopus @ Elsevier (DOI): 10.1186/s40792-019-0673-y (DOI: 10.1186/s40792-019-0673-y, PubMed: 31338648)
79.	Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Kouzou Yoshikawa and Chie Takasu : 免疫チェックポイント時代における漢方とがん免疫, Kampo Medicine, Vol.70, No.2, 162-166, 2019. (Keyword) *漢方薬(薬理学,治療的利用) (Link to Publication Site) ● Publication site (DOI): 10.3937/kampomed.70.162 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390002184855144320 ● Search Scopus @ Elsevier (DOI): 10.3937/kampomed.70.162 (DOI: 10.3937/kampomed.70.162, CiNii: 1390002184855144320)
80.	Tooru Kouno, Mitsuo Shimada, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Hidetoshi Katsuno, Koutarou Maeda, Keisuke Koeda, Satoshi Morita, Masahiko Watanabe, Mitsuo Kusano, Junichi Sakamoto, Shigetoyo Saji, Hiroki Sokuoka, Yasuto Sato, Yoshihiko Maehara, Takashi Kanematsu and Masaki Kitajima : Daikenchuto accelerates the recovery from prolonged postoperative ileus after open abdominal surgery: a subgroup analysis of three randomized controlled trials., Surgery Today, Vol.49, No.8, 704-711, 2019. (Summary) Prolonged postoperative ileus (POI) is a common complication after open abdominal surgery (OAS). Daikenchuto (DKT), a traditional Japanese medicine that peripherally stimulates the neurogenic pathway, is used to treat prolonged POI in Japan. To analyze whether DKT accelerates the recovery from prolonged POI after OAS, we conducted a secondary analysis of three multicenter randomized controlled trials (RCTs). A secondary analysis of the three RCTs supported by the Japanese Foundation for Multidisciplinary Treatment of Cancer (project numbers 39-0902, 40-1001, 42-1002) assessing the effect of DKT on prolonged POI in patients who had undergone OAS for colon, liver, or gastric cancer was performed. The subgroup included 410 patients with no bowel movement (BM) before the first diet, a DKT group (n = 214), and a placebo group (n = 196). Patients received either 5 g DKT or a placebo orally, three times a day. The primary endpoint was defined as the time from the end of surgery to the first bowel movement (FBM). A sensitivity analysis was also performed on the age, body mass index and dosage as subgroup analyses. The primary endpoint was significantly accelerated in the DKT group compared with the placebo group (p = 0.004; hazard ratio 1.337). The median time to the FBM was 113.8 h in the placebo group and 99.1 h in the DKT treatment group. The subgroup analysis showed that DKT significantly accelerated the recovery from prolonged POI following OAS. UMIN000026292. (Keyword) Abdomen / adult / Aged / Aged, 80 and over / Body Mass Index / female / Humans / Ileus / male / Middle Aged / Plant Extracts / Postoperative Complications / Randomized Controlled Trials as Topic / Treatment Outcome (Tokushima University Institutional Repository) ● Metadata: 115809 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-019-01787-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30805720 ● Search Scopus @ Elsevier (PMID): 30805720 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-019-01787-9 (Tokushima University Institutional Repository: 115809, DOI: 10.1007/s00595-019-01787-9, PubMed: 30805720)
81.	Yuuma Wada, Atsushi Takata, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway., Surgery Today, Vol.49, No.6, 536-545, 2019. (Summary) Epigallocatechin 3-gallate (EGCG), a green tea polyphenol, has been shown to have anti-oxidant and anti-inflammatory effects in vitro and in vivo. The aim of this study was to investigate the effects and mechanism of EGCG on isolated pancreatic islets as pre-conditioning for pancreatic islet transplantation. The pancreatic islets were divided into two groups: an islet culture medium group (control) and an islet culture medium with EGCG (100 M) group. We investigated the islet viability, Nrf2 expression, reactive oxygen species (ROS) production, and heme oxygenase-1 (HO-1) mRNA. Five hundred islet equivalents after 12 h of culture for the EGCG 100 M and control group were transplanted under the kidney capsule of streptozotocin-induced diabetic ICR mice. The cell viability and insulin secretion ability in the EGCG group were preserved, and the nuclear translocation of Nrf2 was increased in the EGCG group (p < 0.01). While the HO-1 mRNA levels were also higher in the EGCG group than in the control group (p < 0.05), the ROS production was lower (p < 0.01). An in vivo functional assessment showed that the blood glucose level had decreased in the EGCG group after transplantation (p < 0.01). EGCG protects the viability and function of islets by suppressing ROS production via the Nrf2 pathway. (Keyword) Animals / Blood Glucose / catechin / Cell Survival / gene expression / Heme Oxygenase-1 / In Vitro Techniques / Insulin Secretion / Islets of Langerhans / Islets of Langerhans Transplantation / male / Mice, Inbred C57BL / Mice, Inbred ICR / NF-E2-Related Factor 2 / RNA, Messenger / reactive oxygen species / Tissue Culture Techniques / Transplantation Conditioning (Tokushima University Institutional Repository) ● Metadata: 114154 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-019-1761-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30730004 ● Search Scopus @ Elsevier (PMID): 30730004 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-019-1761-0 (Tokushima University Institutional Repository: 114154, DOI: 10.1007/s00595-019-1761-0, PubMed: 30730004)
82.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Masato Yoshikawa, Hiroki Teraoku and Toshiaki Yoshimoto : A new formula to calculate the resection limit in hepatectomy based on Gd-EOB-DTPA-enhanced magnetic resonance imaging., PLoS ONE, Vol.14, No.1, e0210579, 2019. (Summary) Dynamic magnetic resonance imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (EOB-MRI) can be used not only to detect liver tumors but also to estimate liver function. The aim of this study was to establish a new EOB-MRI-based formula to determine the resection limit in patients undergoing hepatectomy. Twenty-eight patients with a normal liver (NL group) and five with an unresectable cirrhotic liver (UL group) who underwent EOB-MRI were included. Standardized liver function (SLF) was calculated based on the signal intensity (SI), the volume of each subsegment (S1-S8), and body surface area. A formula defining the resection limit was devised based on the difference in the SLF values of patients in the NL and UL groups. The formula was validated in 50 patients who underwent EOB-MRI and hepatectomy. The average SLF value in the NL and UL groups was 2038 and 962 FV/m2, respectively. The difference (1076 FV/m2) was consistent with a 70% in resection volume. Thus, the resection limit for hepatectomy was calculated as a proportion of 70%: 70 (SLF-962)/1076 (%). The one patient who underwent hepatectomy over the resection limit died due to liver failure. In other 49 patients, in whom the resection volume was less than the resection limit, procedures were safely performed. Our formula for resection limit based on EOB-MRI can improve the safety of hepatectomy. (Tokushima University Institutional Repository) ● Metadata: 113041 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0210579 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30682046 ● Search Scopus @ Elsevier (PMID): 30682046 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0210579 (Tokushima University Institutional Repository: 113041, DOI: 10.1371/journal.pone.0210579, PubMed: 30682046)
83.	Yu Saitou, Yuji Morine, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Hisami Yamanaka-Okumura, Akiyoshi Hirayama, Tomoyoshi Soga, Masaru Tomita and Mitsuo Shimada : Changes of liver metabolites following hepatectomy with ischemia reperfusion towards liver regeneration., Annals of Gastroenterological Surgery, Vol.2, No.3, 204-211, 2018. (Summary) Metabolome analysis is one of the omics which investigates the final product of a central dogma. Changes of liver metabolites during liver regeneration following hepatectomy (Hx) continue to remain unclear. The aim of the present study was to investigate the changes of liver metabolites following Hx with ischemia reperfusion (I/R) towards liver regeneration. Twenty-three patients who underwent Hx were enrolled in this study. Non-tumor tissues were sampled immediately before and after Hx and a comparison was made between the liver samples taken before and after Hx using capillary electrophoresis (CE)-time-of-flight mass spectrometry (TOFMS) as metabolome analysis. The metabolic pathway showed that there was a significant increase in "lactate" following Hx. There was a significant decrease in metabolites only in the first half of the tricarboxylic acid cycle (TCA) cycle, and adenosine triphosphate (ATP) by anaerobiotic glycolysis did not occur in time for energy consumption of the Hx. Principal component analysis revealed remarkably different component profiles between the samples taken before and after Hx. One hundred and three metabolites were selected as critical metabolites for separating components. Valine and tryptophan increased significantly after Hx and they were regulated by resected liver volume, ischemic time and liver function. The liver metabolites changed remarkably between before and after Hx. Especially, liver valine and tryptophan were increased. (Link to Publication Site) ● Publication site (DOI): 10.1002/ags3.12058 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29863192 ● Search Scopus @ Elsevier (PMID): 29863192 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12058 (DOI: 10.1002/ags3.12058, PubMed: 29863192)
84.	Toshiaki Yoshimoto, Yuji Morine, Chie Takasu, Rui Feng, Tetsuya Ikemoto, Kouzou Yoshikawa, Shuichi Iwahashi, Yu Saitou, Hideya Kashihara, Masatake Akutagawa, Takahiro Emoto, Yosuke Kinouchi and Mitsuo Shimada : Blue light-emitting diodes induce autophagy in colon cancer cells by Opsin 3., Annals of Gastroenterological Surgery, Vol.2, No.2, 154-161, 2018. (Summary) Light emitting-diodes (LED) have various effects on living organisms and recent studies have shown the efficacy of visible light irradiation from LED for anticancer therapies. However, the mechanism of LED's effects on cancer cells remains unclear. The aim of the present study was to investigate the effects of LED on colon cancer cell lines and the role of photoreceptor Opsin 3 (Opn3) on LED irradiation in vitro. Human colon cancer cells (HT-29 or HCT-116) were seeded onto laboratory dishes and irradiated with 465-nm LED at 30 mW/cm for 30 minutes. Cell Counting Kit-8 was used to measure cell viability, and apoptosis and caspase 3/8 expression were evaluated by AnnexinV/PI and reverse transcription-polymerase chain reaction (RT-PCR), respectively. Autophagy and expression of LC-3 and beclin-1 were also evaluated by autophagy assays, RT-PCR and Western blotting. We further tested Opn3 knockdown by Opn3 siRNA and the G G-protein inhibitor NF023 in these assays. Viability of HT-29 and HCT-116 cells was lower in 465-nm LED-irradiated cultures than in control cultures. LC-3 and beclin-1 expressions were significantly higher in LED-irradiated cultures, and autophagosomes were detected in irradiated cells. The reductive effect of cancer cell viability following blue LED irradiation was reversed by Opn3 knockdown or NF023 treatment. Furthermore, increased LC-3 and beclin-1 expression that resulted from blue LED irradiation was suppressed by Opn3 knockdown or NF023 treatment. Blue LED irradiation suppressed the growth of colon cancer cells and Opn3 may play an important role as a photoreceptor. (Tokushima University Institutional Repository) ● Metadata: 113689 (Link to Publication Site) ● Publication site (DOI): 10.1002/ags3.12055 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29863164 ● Search Scopus @ Elsevier (PMID): 29863164 ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12055 (Tokushima University Institutional Repository: 113689, DOI: 10.1002/ags3.12055, PubMed: 29863164)
85.	Toshiaki Yoshimoto, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Masato Yoshikawa, Jun Higashijima, Chie Takasu and Mitsuo Shimada : Maximum Diameter and Number of Tumors as a New Prognostic Indicator of Colorectal Liver Metastases., In Vivo, Vol.31, No.3, 419-423, 2017. (Summary) Surgical resection is currently considered the only potentially curative option as a treatment strategy of colorectal liver metastases (CRLM). However, the criteria for selection of resectable CRLM are not clear. The aim of this study was to confirm a new prognostic indicator of CRLM after hepatic resection. One hundred thirty nine patients who underwent initial surgical resection from 1994 to 2015 were investigated retrospectively. Prognostic factors of overall survival including the product of maximum diameter and number of metastases (MDN) were analyzed. Primary tumor differentiation, vessel invasion, lymph node (LN) metastasis, non-optimally resectable metastases, H score, grade of liver metastases, resection with non-curative intent and MDN were found to be prognostic factors of overall survival (OS). In multivariate analyses of clinicopathological features associated with OS, MDN and non-curative intent were independent prognostic factors. Patients with MDN ·30 had shown significantly poorer prognosis than patients with MDN <30 in OS and relapse-free survival (RFS). MDN ·30 is an independent prognostic factor of survival in patients with CRLM and optimal surgical criterion of hepatectomy for CRLM. (Keyword) Adult / Aged / Aged, 80 and over / Cell Differentiation / Colorectal Neoplasms / Female / Follow-Up Studies / Hepatectomy / Humans / Liver Neoplasms / Lymphatic Metastasis / Male / Middle Aged / Multivariate Analysis / Prognosis / Retrospective Studies (Link to Publication Site) ● Publication site (DOI): 10.21873/invivo.11076 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28438872 ● Search Scopus @ Elsevier (PMID): 28438872 ● Search Scopus @ Elsevier (DOI): 10.21873/invivo.11076 (DOI: 10.21873/invivo.11076, PubMed: 28438872)
86.	Masato Yoshikawa, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Jun Higashijima, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : Elevated Preoperative Serum CEA Level Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition., Anticancer Research, Vol.37, No.3, 1169-1175, 2017. (Summary) Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial-mesenchymal transition (EMT) and tumor angiogenesis. One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis. (Keyword) Adult / Aged / Aged, 80 and over / Antigens, CD / Antigens, CD34 / Cadherins / Carcinoembryonic Antigen / Carcinoma, Hepatocellular / Cell Adhesion Molecules / Disease-Free Survival / Epithelial-Mesenchymal Transition / Female / Follow-Up Studies / Humans / Immunohistochemistry / Liver Neoplasms / Male / Microcirculation / Middle Aged / Neovascularization, Pathologic / Predictive Value of Tests / Preoperative Period / Prognosis / Recurrence / Vimentin (Tokushima University Institutional Repository) ● Metadata: 112034 (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.11430 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28314278 ● Search Scopus @ Elsevier (PMID): 28314278 ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.11430 (Tokushima University Institutional Repository: 112034, DOI: 10.21873/anticanres.11430, PubMed: 28314278)
87.	M Davaadorj, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Chie Takasu, Shin-ichiro Yamada, Hiroki Teraoku, Masato Yoshikawa and Mitsuo Shimada : Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma., EJSO - European Journal of Surgical Oncology, Vol.43, No.2, 344-350, 2017. (Summary) Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)- -catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt- -catenin pathway. Fifty IHCC patients who had liver resection were enrolled in this study. SFRP1 protein expression was examined by immunohistochemistry in tumor tissues. The patients were divided into two groups: SFRP1 positive (n = 30) and negative (n = 20). Clinicopathological characteristics were analyzed. SFRP1 significantly correlated with curability (Cur A, B vs. C, p = 0.029); and recurrent pattern (intrahepatic vs. extrahepatic, p = 0.010). The negative SFRP1 group had significantly poorer prognosis, and 5-year survival rates were 8.1% of the negative SFRP1 group and 44.6% of the positive SFRP1 group, respectively. Moreover, the disease-free survival rate in the negative SFRP1 group was significantly poorer (p < 0.001). Multivariate analysis revealed that loss of SFRP1served as an independent prognostic factor in IHCC for both overall (HR, 2.923; 95% CI, 1.30-6.56; p = 0.009) and disease-free (HR, 2.631; 95% CI, 1.31-5.27; p = 0.006) survival. In addition, SFRP1 expression negatively correlated to -catenin expression (p = 0.005). Those results suggested that the loss of SFRP1 could be a poor prognostic factor for IHCC, through the Wnt- -catenin pathway. (Keyword) Aged / Biomarkers, Tumor / Cholangiocarcinoma / Female / Hepatectomy / Humans / Immunohistochemistry / Japan / Liver Neoplasms / Male / Prognosis / Proteins / Survival Rate (Tokushima University Institutional Repository) ● Metadata: 110034 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ejso.2016.11.017 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28062160 ● Search Scopus @ Elsevier (PMID): 28062160 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejso.2016.11.017 (Tokushima University Institutional Repository: 110034, DOI: 10.1016/j.ejso.2016.11.017, PubMed: 28062160)
88.	Daichi Ishikawa, Mitsuo Shimada, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Shinichiro Yamada and Hidenori Miyake : Effect of Twist and Bmi1 on intraductal papillary mucinous neoplasm of the pancreas., Journal of Gastroenterology and Hepatology, Vol.29, No.12, 2032-2037, 2014. (Summary) Intraductal papillary mucinous neoplasm (IPMN) is a well-established entity among pancreatic neoplasms that ranges from low-grade dysplasia to invasive carcinoma. Epithelial-mesenchymal transition (EMT) contributes to tumor progression in various cancers. Moreover, Notch signaling is one of the important upstream effectors of EMT promotion. Currently, it is unclear whether EMT causes pathological progression of IPMN. We evaluated the expression of EMT-promoting transcription factors Twist and B cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) in IPMN. Patients who underwent resections at our institute and its affiliated hospital were enrolled in this study (n = 35). Protein expression of EMT markers Twist, Bmi1, Jagged1, and E-cadherin in resected specimens was investigated by immunohistochemistry. Expression of these proteins was compared with the clinicopathological factors and patient survival. Positive expression of Twist and Bmi1 was observed in 40.0% and 42.9% of IPMNs, respectively. Twist and Bmi1 expression was significantly higher in IPMNs with high-grade dysplasia (P < 0.05) and invasive carcinoma (P < 0.05) than that in IPMNs with low-grade dysplasia. High expression of Twist was correlated with Jagged1 expression and inversely correlated with expression of E-cadherin (P = 0.06 and P < 0.05, respectively). In survival analyses, the recurrence rate was significantly higher in the group that showed simultaneous high expression of Twist and Bmi1 (P < 0.05). Expression of Twist and Bmi1 is associated with aggressiveness and poor prognoses of IPMN through EMT promotion that might be induced by Notch signaling. (Tokushima University Institutional Repository) ● Metadata: 106298 (Link to Publication Site) ● Publication site (DOI): 10.1111/jgh.12652 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24909638 ● Search Scopus @ Elsevier (PMID): 24909638 ● Search Scopus @ Elsevier (DOI): 10.1111/jgh.12652 (Tokushima University Institutional Repository: 106298, DOI: 10.1111/jgh.12652, PubMed: 24909638)
89.	Gizachew Yismaw Wubetu, Tohru Utsunomiya, Daichi Ishikawa, Tetsuya Ikemoto, Shinichiro Yamada, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Yusuke Arakawa, Satoru Imura, Hideki Arimochi and Mitsuo Shimada : Branched chain amino acid suppressed insulin-initiated proliferation of human cancer cells through induction of autophagy., Anticancer Research, Vol.34, No.9, 4789-4796, 2014. (Summary) Branched chain amino acid (BCAA) dietary supplementation inhibits activation of the insulin-like growth factor (IGF)/IGF-I receptor (IGF-IR) axis in diabetic animal models. However, the in vitro effect of BCAA on human cancer cell lines under hyper-insulinemic conditions remains unclear. Colon (HCT-116) and hepatic (HepG2) tumor cells were treated with varying concentrations of BCAA with or without fluorouracil (5-FU). The effect of BCAA on insulin-initiated proliferation was determined. Gene and protein expression was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting, respectively. BCAA supplementation had no significant effect on cell proliferation and did not show significant synergistic or antagonistic effects with 5-FU. However, BCAA significantly decreased insulin-initiated proliferation of human colon and hepatic cancer cell lines in vitro. BCAA supplementation caused a marked decrease in activated IGF-IR expression and significantly enhanced both mRNA and protein expression of LC3-II and BECN1 (BECLIN-1). BCAA could be a useful chemopreventive modality for cancer in hyperinsulinemic conditions. (Keyword) Amino Acids, Branched-Chain / Apoptosis / Autophagy / Cell Line, Tumor / Cell Proliferation / Dietary Supplements / HCT116 Cells / Hep G2 Cells / Humans / Insulin / Phosphorylation / Receptor, IGF Type 1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25202059 ● Search Scopus @ Elsevier (PMID): 25202059 (PubMed: 25202059)
90.	Gizachew Yismaw Wubetu, Tohru Utsunomiya, Daichi Ishikawa, Shinichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Yusuke Arakawa, Satoru Imura, Mami Kanamoto, Chengzhan Zhu, Yoshimi Bando and Mitsuo Shimada : High STAT4 expression is a better prognostic indicator in patients with hepatocellular carcinoma after hepatectomy., Annals of Surgical Oncology, Vol.21 Suppl 4, S721-8, 2014. (Summary) Signal transducer and activator of transcription 4 (STAT4) mediates the intracellular effects of interleukin-12, leading to the production of interferon gamma (IFN-γ) and natural killer cells cytotoxicity. However, the clinical significance of STAT4 expression in patients with hepatocellular carcinoma (HCC) remains virtually unknown. A total of 66 HCC patients who underwent hepatectomy were enrolled in this study. Quantitative real-time polymerase chain reaction was performed to determine STAT4 and IFNG mRNA expression levels. Tissue microarray-based immunohistochemistry was performed to examine CD8(+) T cells, STAT4, and INF-γ proteins. STAT4 was differentially expressed in tumor and nontumor tissues (P = 0.001) and positively correlated with IFNG expression (R (2) = 0.506, P < 0.05) and CD8(+) T cell infiltration (R (2) = 0.53, P < 0.001). Significant correlations were observed between STAT4 expression and tumor TNM stage (P = 0.043), hepatic venous invasion (P = 0.003), des-gamma-carboxy prothrombin (P = 0.011), tumor size (P = 0.036), and tumor differentiation (P = 0.034). Patients with high STAT4 expression had significantly better recurrence-free survival (P = 0.009). Low STAT4 expression (P = 0.030) and presence of portal venous invasion or hepatic venous invasion (P = 0.006) were independent risk factors for HCC recurrence. Downregulation of STAT4 in HCC indicated aggressive tumor behavior and predicted a worse clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after hepatectomy. (Tokushima University Institutional Repository) ● Metadata: 109697 (Link to Publication Site) ● Publication site (DOI): 10.1245/s10434-014-3861-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24965572 ● Search Scopus @ Elsevier (PMID): 24965572 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-014-3861-9 (Tokushima University Institutional Repository: 109697, DOI: 10.1245/s10434-014-3861-9, PubMed: 24965572)
91.	Noriko Matsumoto, Yuji Morine, Tohru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shiniciro Yamada, Daichi Ishikawa, Chie Takasu, Hidenori Miyake and Mitsuo Shimada : Role of CD151 expression in gallbladder carcinoma., Surgery, Vol.156, No.5, 1212-1217, 2014. (Summary) CD151 is a member of the tetraspanin family, which interacts with laminin-binding integrins and other tetraspanins. CD151 is involved in several pathologic activities associated with tumor progression, including metastasis and angiogenesis. The aim of this study was to clarify the clinical use of CD151 expression in gallbladder cancer (GBC). Forty-five patients with GBC who had undergone operative treatment were enrolled in this study. Expressions of CD151 in the resected GBC specimens were evaluated with anti-CD151 antibody. The patients were divided into positive and negative groups according to CD151 expression: CD151-positive group (n = 26) and CD151-negative group (n = 19). Clinicopathologic factors, including Ki-67 and matrix metallopeptidase 9, also were compared between the two groups. CD151-positive expression was 58% and correlated with poorer prognosis; 5-year survival of CD151-positive and CD151-negative groups was 29% and 78%, respectively (P = .006). CD151 expression also correlated with lymphatic invasion and curability. Multivariate analysis revealed that CD151-positive expression was an independent prognostic factor (hazard ratio 2.97, P = .02). In addition, CD151 expression correlated with matrix metallopeptidase 9 expression (P < .05) but not with Ki67 expression. Those findings suggested that CD151-positive expression might be a potential prognostic indicator and one of the target molecules for the regulation of tumor metastasis for patients with GBC. (Keyword) Adult / Aged / Aged, 80 and over / Antigens, CD151 / Carcinoma / Female / Gallbladder / Gallbladder Neoplasms / Humans / Immunohistochemistry / Ki-67 Antigen / Male / Matrix Metalloproteinase 9 / Middle Aged / Multivariate Analysis / Prognosis / Tumor Markers, Biological (Link to Publication Site) ● Publication site (DOI): 10.1016/j.surg.2014.04.053 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24890568 ● Search Scopus @ Elsevier (PMID): 24890568 ● Search Scopus @ Elsevier (DOI): 10.1016/j.surg.2014.04.053 (DOI: 10.1016/j.surg.2014.04.053, PubMed: 24890568)
92.	Chinbold Enkhbold, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa and Mitsuo Shimada : Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma., Hepatology Research, Vol.44, No.14, E346-52, 2014. (Summary) FBXW7 acts as a tumor suppressor gene by targeting several oncogenic regulators of proliferation, growth and apoptosis for proteasomal degradation. However, the significance of this protein is not yet well understood in intrahepatic cholangiocarcinoma (IHCC). In this study, we aimed to investigate the correlation between FBXW7 expression and clinicopathological variables in IHCC patients. Thirty-one patients with IHCC who underwent hepatic resection were enrolled. FBXW7 expression in tumor tissue was determined by immunohistochemistry and patients were divided into two groups, the FBXW7 high expression group (n = 11) and the FBXW7 low expression group (n = 20). We then compared clinicopathological variables including prognosis between the high and low expression groups in tumor tissue. FBXW7 expression was significantly correlated with staging (P = 0.006), and tended to correlate with lymph node metastasis. The FBXW7 low expression group had significantly poorer prognosis compared with the FBXW7 high expression group (P = 0.020); 3-year survival rates were 29.4% and 72.7%, respectively. Furthermore, the disease-free survival rate in the FBXW7 low expression group was significantly worse than in the FBXW7 high expression group (P = 0.022). On multivariate analysis, intrahepatic metastasis (P = 0.006) was a significant independent prognostic factor for disease-free survival, and FBXW7 low expression tended to be an independent prognostic factor for both overall (P = 0.067) and disease-free survival (P = 0.083). Our results confirmed that low expression of FBXW7 in IHCC correlates with tumor progression and poor prognosis in IHCC. (Tokushima University Institutional Repository) ● Metadata: 109369 (Link to Publication Site) ● Publication site (DOI): 10.1111/hepr.12314 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24552289 ● Search Scopus @ Elsevier (PMID): 24552289 ● Search Scopus @ Elsevier (DOI): 10.1111/hepr.12314 (Tokushima University Institutional Repository: 109369, DOI: 10.1111/hepr.12314, PubMed: 24552289)
93.	Shinichiro Yamada, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusue Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Daichi Ishikawa and Mitsuo Shimada : Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy., Annals of Surgical Oncology, Vol.21 Suppl 3, S436-42, 2014. (Summary) Radiofrequency ablation (RFA) is a widely used therapy for hepatocellular carcinoma (HCC). Several reports have demonstrated the aggressive local recurrence of HCC after RFA, suggesting that induction of further malignant transformation of HCC has occurred. Eighty-eight (88) patients with HCC who underwent hepatic resection were included in this study. Hepatectomy was indicated for local recurrence of HCC after RFA (n = 10, RFA group) and for HCC without prior RFA (n = 78, non-RFA group). Clinicopathological data and the patient's prognosis after hepatectomy were compared between the two groups. Expression levels of hypoxia-inducible factor-1 (HIF-1), epithelial cell adhesion molecule (EpCAM), CD44, and vascular endothelial growth factor messenger RNA (mRNA) in the tumor tissues were also examined. The RFA group showed higher frequency of portal vein invasion and less tumor differentiation compared with the non-RFA group (p < 0.05). Overall and disease-free survival rates in the RFA group were significantly worse than those in the non-RFA group (p < 0.05). HIF-1 and EpCAM mRNA expression levels in the RFA group were significantly higher than those in the non-RFA group (p < 0.05). These results suggest that local HCC recurrence after RFA shows an aggressive tumor phenotype and poor prognosis through the enhanced expressions of HIF-1 and EpCAM in the residual HCC tumors after insufficient or sub-lethal treatment by RFA. (Keyword) Aged / Antigens, CD44 / Antigens, Neoplasm / Carcinoma, Hepatocellular / Case-Control Studies / Catheter Ablation / Cell Adhesion Molecules / Combined Modality Therapy / Female / Follow-Up Studies / Hepatectomy / Humans / Hypoxia-Inducible Factor 1, alpha Subunit / Liver Neoplasms / Male / Neoplasm Recurrence, Local / Neoplasm Staging / Neoplasm, Residual / Prognosis / RNA, Messenger / Real-Time Polymerase Chain Reaction / Reverse Transcriptase Polymerase Chain Reaction / Survival Rate / Tumor Markers, Biological (Link to Publication Site) ● Publication site (DOI): 10.1245/s10434-014-3575-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24566861 ● Search Scopus @ Elsevier (PMID): 24566861 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-014-3575-z (DOI: 10.1245/s10434-014-3575-z, PubMed: 24566861)
94.	Akira Nii, Tohru Utsunomiya, Mitsuo Shimada, Toru Ikegami, Hiroki Ishibashi, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hajime Sasaki and Akihiro Kawashima : A hydrolyzed whey peptide-based diet ameliorates hepatic ischemia-reperfusion injury in the rat nonalcoholic fatty liver., Surgery Today, Vol.44, No.12, 2354-2360, 2014. (Summary) The number of patients with nonalcoholic fatty liver disease (NAFLD) is increasing. Hepatic steatosis is a major risk factor for hepatic failure after ischemia-reperfusion (I/R) injury. Hydrolyzed whey peptide (HWP) is a functional liquid-type nutritional diet containing whey peptide, which has previously been shown to exert anti-inflammatory effects. In the present study, we examined the effects of HWP on the hepatic I/R injury in a rat NAFLD model. Rats fed a methionine/choline-deficient diet for 4 weeks were divided into two groups after 30 min of whole liver ischemia. In Group-M, HWP was given immediately after reperfusion and every 6 h thereafter. In Group-C, the vehicle was given in the same manner. The liver function tests and microscopic findings of the liver after reperfusion were compared between the two groups. The serum transaminase levels in Group-M were significantly lower than those in Group-C after reperfusion. The gene expression levels of IL-6 and inducible nitric oxide synthase (iNOS) were significantly lower in Group-M compared to Group-C. The TNF-α and uncoupling protein-2 (UCP-2) expression levels were also markedly lower in Group-M. The hepatic necrotic areas in Group-M were significantly smaller than those in Group-C. The administration of a HWP diet ameliorated the hepatic I/R injury in rats with NAFLD. (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-014-0853-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24492979 ● Search Scopus @ Elsevier (PMID): 24492979 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-014-0853-0 (DOI: 10.1007/s00595-014-0853-0, PubMed: 24492979)
95.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 3.肝疾患ウイルス性肝炎, 日本臨床外科学会誌, Vol.69, No.11, 2014.
96.	Shuichi Iwahashi, Satoru Imura, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Yu Saitou, Chie Takasu and Mitsuo Shimada : 肝移植, 日本臨床外科学会誌, Vol.69, No.4, 2014.
97.	Shinichiro Yamada, Mitsuo Shimada, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and Yu Saitou : CXC receptor 4 and stromal cell-derived factor 1 in primary tumors and liver metastases of colorectal cancer., The Journal of Surgical Research, Vol.187, No.1, 107-112, 2013. (Summary) It has been determined that the chemokine receptor CXC receptor 4 (CXCR4) and its ligand, stromal cell-derived factor 1 (SDF-1), regulate several key processes in a wide variety of cancers. In this study, we investigate the possible role of SDF-1 (noncancerous liver tissue) and CXCR4 in liver metastases of colorectal cancer (CRC). Reverse transcription-polymerase chain reaction was performed to examine the expression of SDF-1 in noncancerous liver tissues of 16 CRC patients with liver metastasis and in normal liver tissues of six patients with benign liver disease. We also examined the expression of CXCR4 in cancerous tissues from primary and metastatic tumors. Using reverse transcription-polymerase chain reaction, CXCR4 expression in metastatic tumors tended to be higher than that in primary tumors (P = 0.16). High CXCR4 expression in a primary tumor was found to be related to an increased lymphatic invasion (P = 0.01), an advanced depth of tumor invasion (P = 0.07), and a decrease in the overall survival rate. The SDF-1 expression observed in noncancerous liver tissues of CRC with liver metastasis was significantly higher than that observed in normal liver tissues of benign liver disease (P < 0.05). In CRC with liver metastasis, CXCR4 expression demonstrated associations with local progression, liver metastasis, and poor overall survival. (Keyword) Aged / Chemokine CXCL12 / Colorectal Neoplasms / Female / Humans / Liver Neoplasms / Male / Middle Aged / Neoplasm Staging / Prognosis / Receptors, CXCR4 / Retrospective Studies / Risk Factors (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jss.2013.10.030 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24238971 ● Search Scopus @ Elsevier (PMID): 24238971 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jss.2013.10.030 (DOI: 10.1016/j.jss.2013.10.030, PubMed: 24238971)
98.	Chie Takasu, Mitsuo Shimada, Hirohiko Sato, Tomohiko Miyatani, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Nobuhiro Kurita, Shohei Eto and Tohru Utsunomiya : Benefits of simultaneous laparoscopic resection of primary colorectal cancer and liver metastases., Asian Journal of Endoscopic Surgery, Vol.7, No.1, 31-37, 2013. (Summary) Recently, consensus on the optimal strategy for resectable synchronous colorectal liver metastases (LM) seems to have shifted toward simultaneous resection. However, there are still relatively few reports about simultaneous laparoscopic resection. The aim of this study is to evaluate the outcomes of patients who underwent simultaneous laparoscopic resection. We evaluated 14 patients who underwent simultaneous resection of primary colorectal cancer and LM in our hospital from 2004 to 2012. Patients were selected by matched pair analysis based on the number of LM (≤4) and tumor size (≤5 cm). We divided them into two groups: the simultaneous laparoscopic resection of primary colorectal cancer and LM (Lap-S) group (n = 7) and the simultaneous open resection of primary colorectal cancer and LM (Open-S) group (n = 7). Clinical and oncologic outcomes were compared between the groups. The Lap-S patients were significantly older than the Open-S patients. The mean operative times of Lap-S and Open-S were 472 min and 466 min, respectively. The mean blood loss was significantly smaller in the Lap-S group (153 mL) than in the Open-S group (496 mL). There was no surgical mortality in either group. The incidence of postoperative complications in the Lap-S and Open-S groups was 12.3% and 33.0%, respectively. The mean postoperative hospital stay was significantly shorter in the Lap-S group (16 days) than in the Open-S group (36 days). There was no significant difference in long-term survival between the two groups. Lap-S patients had equivalent long-term outcomes to Open-S patients. Therefore, given its technical feasibility and safety, Lap-S may be one of the most promising options in selected patients. (Keyword) Aged / Aged, 80 and over / Colectomy / Colorectal Neoplasms / Feasibility Studies / Female / Follow-Up Studies / Hepatectomy / Humans / Kaplan-Meier Estimate / Laparoscopy / Length of Stay / Liver Neoplasms / Male / Middle Aged / Operative Time / Postoperative Complications / Retrospective Studies / Survival Rate / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1111/ases.12066 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24127772 ● Search Scopus @ Elsevier (PMID): 24127772 ● Search Scopus @ Elsevier (DOI): 10.1111/ases.12066 (DOI: 10.1111/ases.12066, PubMed: 24127772)
99.	Lkhagva-Ochir Tovuu, Tohru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, Koji Sugimoto, Yu Saitou, Shinichiro Yamada, Michihito Asanoma and Mitsuo Shimada : The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma., International Journal of Clinical Oncology, Vol.19, No.4, 622-628, 2013. (Summary) Aurora B is a serine-threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue. Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups. Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue (P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group (P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time. Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC. (Keyword) Adult / Aged / Aurora Kinase B / Carcinoma, Hepatocellular / Disease-Free Survival / Female / Gene Expression Regulation, Neoplastic / Humans / Liver / Liver Neoplasms / Male / Middle Aged / Prognosis / Prothrombin Time / Tumor Markers, Biological (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-013-0593-y (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23893130 ● Search Scopus @ Elsevier (PMID): 23893130 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-013-0593-y (DOI: 10.1007/s10147-013-0593-y, PubMed: 23893130)

Review, Commentary:

1.	Yu Saitou, Yasuhiro Hamada, Sonoko Yasui-Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 周術期の体組成評価:―サルコペニアの観点より―, The Japanese Journal of Surgical Metabolism and Nutrition, Vol.53, No.4, 147-156, Aug. 2019. (Link to Publication Site) ● Publication site (DOI): 10.11638/jssmn.53.4_147 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.53.4_147 (DOI: 10.11638/jssmn.53.4_147)
2.	Hiroki Ishibashi, Mitsuo Shimada, Hiroki Mori, Yuji Morine and 安藤久實 : 膵・胆管合流異常と胆道癌(特集慢性炎症から肝胆膵癌にいたるランドスケープ), KAN TAN SUI, Vol.77, No.8, 659-667, Apr. 2019.
3.	Yoichiro Kawashita, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shuichi Iwahashi, Shin-ichiro Yamada, Jun Higashijima, Satoru Imura, Hirohisa Ogawa, Toshiyuki Yagi and Mitsuo Shimada : Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.24, No.10, 576-583, Oct. 2017. (Summary) Fbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism. Fifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low groups. Clinicopathological factors including miR-223 expression were compared between the high (n = 32) and low Fbxw7 groups (n = 24). Fbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3 years disease-free survival of the low and high Fbxw7 groups were 12.5% and 47.0%, respectively (P = 0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factors for recurrence of CRLM (hazard ratio: 2.390, P = 0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (P = 0.017). Loss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR-223 might be a possible regulator of Fbxw7. (Tokushima University Institutional Repository) ● Metadata: 110995 (Link to Publication Site) ● Publication site (DOI): 10.1002/jhbp.500 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28846828 ● Search Scopus @ Elsevier (PMID): 28846828 ● Search Scopus @ Elsevier (DOI): 10.1002/jhbp.500 (Tokushima University Institutional Repository: 110995, DOI: 10.1002/jhbp.500, PubMed: 28846828)
4.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima and Mitsuo Shimada : Treatment strategy of conversion hepatectomy for colorectal liver metastasis, Journal of Clinical Surgery, Vol.72, No.10, 1211-1216, Oct. 2017. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390283684865555456 (CiNii: 1390283684865555456)
5.	Shuichi Iwahashi, Hiroki Teraoku, Yu Saitou, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 【どこをどう切る?どうつなぐ?なぞって覚える!消化器外科術式理解イラストノート】肝臓・胆道の手術肝切除術, Gastroenterological Surgery Nursing, Vol.22, No.8, 704-708, Oct. 2017.
6.	Yuji Morine and Mitsuo Shimada : 胆・膵嚢胞切除先天性胆道拡張症に対する手術, 臨床外科, Vol.72, No.11, 235-240, Oct. 2017.
7.	Hideya Kashihara, Yuji Morine, Jun Higashijima, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : 【胆膵進行癌に対する外科治療戦略】閉塞性黄疸に対する最新の術前減黄戦略, Surgery, Vol.79, No.8, 708-713, Aug. 2017. (Keyword) 術前減黄処置 / 分肝機能 / 胆汁返還 / 大建中湯 (Link to Publication Site) ● Publication site (DOI): 10.15106/j00393.2017324283 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390846634830490368 ● Search Scopus @ Elsevier (DOI): 10.15106/j00393.2017324283 (DOI: 10.15106/j00393.2017324283, CiNii: 1390846634830490368)
8.	Masaaki Nishi, Mitsuo Shimada, Kouzou Yoshikawa, Yuji Morine, Jun Higashijima, Hideya Kashihara, Chie Takasu and Daichi Ishikawa : 【がん治療医のための漢方ハンドブック】漢方と癌診療, 臨床外科, Vol.72, No.8, 917-921, Aug. 2017.
9.	Hiroki Ishibashi, Mitsuo Shimada, Yuji Morine, Keigo Yada and Hiroki Mori : 【先天性胆道拡張症の最前線】先天性胆道拡張症の診療ガイドライン, Journal of Biliary Tract & Pancreas, Vol.38, No.4, 329-337, Apr. 2017.
10.	Shin-ichiro Yamada, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Masato Yoshikawa, Hiroki Teraoku, Toshiaki Yoshimoto and Atsushi Takata : Effective stepwise training and procedure standardization for young surgeons to perform laparoscopic left hepatectomy., Surgical Endoscopy, Vol.31, No.6, 2623-2629, Dec. 2016. (Summary) Laparoscopic hepatectomy remains one of the most difficult procedures for young surgeons to perform. We recently developed a new training method and standardization procedure for teaching young surgeons to perform laparoscopic left hepatectomy (Lap-LHx). The aim of this study was to assess the effectiveness of our method. In 2004, we standardized a laparoscopic procedure for Lap-LHx, using a laparoscopy-assisted method as a stepping stone. The laparoscopic training method comprised the following three steps: (1) training in fundamental procedures using a dry box and checking by mentors; (2) detailed preoperative simulation using Vincent three-dimensional software for each patient; and (3) self-assessment including understanding of relevant anatomy and completion grade for each procedure using a check sheet and feedback by both mentors and a professor. Twenty-three Lap-LHx procedures performed during the study period were divided into two groups: those performed by young non-board-certified surgeons (n = 9) and those performed by senior board-certified surgeons (n = 14). The blood loss and operative time were similar in the young surgeon (194 g and 336 min, respectively) and senior surgeon groups (208 g and 322 min, respectively). Our standardized Lap-LHx procedure and stepwise training to perform it enable young surgeons to perform Lap-LHx as confidently and safely as more experienced surgeons. (Link to Publication Site) ● Publication site (DOI): 10.1007/s00464-016-5273-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27928671 ● Search Scopus @ Elsevier (PMID): 27928671 ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-016-5273-3 (DOI: 10.1007/s00464-016-5273-3, PubMed: 27928671)
11.	Shinichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa, Hiroki Teraoku and Mitsuo Shimada : Liver regeneration after splenectomy in patients with liver cirrhosis., Hepatology Research, Vol.46, No.5, 443-449, Oct. 2016. (Summary) Splenectomy is a well-known procedure to improve thrombocytopenia and liver function in patients with liver cirrhosis (LC). However, the effect of splenectomy on liver regeneration remains unclear. The aim of this study is to investigate the effect of splenectomy on liver regeneration. Twenty patients with LC who underwent splenectomy were included in this study. Liver and splenic volumes were measured by a 3-D simulation imaging system. Liver volume (LV) and clinicopathological data were compared before and 6 months after splenectomy. Thereafter, patients were divided into two groups: the elevated LV group and the reduced LV group. Patient characteristics were compared between the two groups. Postoperative LV was increased in 14 patients compared with the preoperative state. Thrombocytopenia, leukopenia, total bilirubin and prothrombin time were improved after splenectomy. In the elevated LV group, four patients exhibited improved Child-Pugh grades after splenectomy, whereas no patients demonstrated improvement in the reduced LV group. The elevated LV group exhibited high albumin level, good indocyanine green retention rate at 15 min and large splenic volume compared with the same measurements in the decreased group. Patients with larger spleen volumes and higher albumin values before splenectomy showed increased rates of LV after splenectomy. Splenectomy for patients with LC improved pancytopenia and liver function. Especially, in patients with large spleen and high albumin levels, considerable increases in LV and improved liver function were observed. (Link to Publication Site) ● Publication site (DOI): 10.1111/hepr.12573 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26428414 ● Search Scopus @ Elsevier (PMID): 26428414 ● Search Scopus @ Elsevier (DOI): 10.1111/hepr.12573 (DOI: 10.1111/hepr.12573, PubMed: 26428414)
12.	Shuichi Iwahashi, Mitsuo Shimada, Tohru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Chie Takasu, Yu Saitou and Shinichiro Yamada : Epithelial-mesenchymal transition-related genes are linked to aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation., Cancer Letters, Vol.375, No.1, 47-50, Mar. 2016. (Summary) We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expression of epithelial-mesenchymal transition (EMT)-related genes and miRNAs. Ten patients with recurrent HCC post-RFA who underwent hepatectomy (RFA group) and 78 patients with HCC without prior RFA (non-RFA group) were enrolled. We examined expression of transforming growth factor (TGF)-β, Twist, vimentin, and Snail-1 mRNAs in tumor tissues, and expression of miR-34a and miR-200c. Expression of TGF-β, Twist and Snail-1 in the RFA group was significantly higher than that in the non-RFA group (P < 0.05); vimentin expression in the RFA group was higher than that in the non-RFA group (P = 0.07). Expression of miR-200c and miR-34a in the RFA group was significantly lower than that in the non-RFA group (miR-200c: P = 0.04; miR-34a: P < 0.01). Increased expression of EMT markers through down-regulation of miRNA expression in RLTs after RFA may be related to poor prognoses of HCC patients with aggressive local recurrence after RFA. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.canlet.2016.02.041 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26940140 ● Search Scopus @ Elsevier (PMID): 26940140 ● Search Scopus @ Elsevier (DOI): 10.1016/j.canlet.2016.02.041 (DOI: 10.1016/j.canlet.2016.02.041, PubMed: 26940140)
13.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yu Saitou and Shin-ichiro Yamada : 【最新肝胆膵高難度外科手術アトラス】高難度外科手術手技肝臓肝下部下大静脈再建を伴う肝切除, Operation, Vol.70, No.4, 431-438, Mar. 2016. (Keyword) *下大静脈(外科的療法)
14.	Yu Saitou, Yasuhiro Hamada, Sonoko Yasui, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 【外科領域におけるサルコペニア】周術期サルコペニア発生の予防法, The Japanese Journal of Surgical Metabolism and Nutrition, Vol.50, No.1, 21-28, Feb. 2016. (Keyword) 周術期 / サルコペニア / 予防 (Link to Publication Site) ● Publication site (DOI): 10.11638/jssmn.50.1_21 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679740177664 ● Search Scopus @ Elsevier (DOI): 10.11638/jssmn.50.1_21 (DOI: 10.11638/jssmn.50.1_21, CiNii: 1390282679740177664)
15.	Gizachew Yismaw Wubetu, Yuji Morine, Hiroki Teraoku, Masato Yoshikawa, Daichi Ishikawa, Shinichiro Yamada, Tetsuya Ikemoto, Yu Saitou, Satoru Imura and Mitsuo Shimada : High NEK2 Expression Is a Predictor of Tumor Recurrence in Hepatocellular Carcinoma Patients After Hepatectomy., Anticancer Research, Vol.36, No.2, 757-762, Feb. 2016. (Summary) Better prognosis of cancer including hepatocellular carcinoma (HCC) remains unsatisfactory due to recurrence and chemoresistance. In this respect it is important to identify molecular targets specific to the disease in order to design effective therapeutic strategies. In the present study, we investigated the prognostic role of Never-in-mitosis-A-related kinase 2 (NEK2) in HCC. Fifty HCC patients who underwent hepatectomy were enrolled in the study. NEK2 gene and protein expression was examined by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry, respectively. Higher expression of NEK2 was detected in HCC tumoral compared to adjacent non-tumor tissues (p<0.001), and protein expression was also relatively high in tumor than corresponding non-tumor tissues. Furthermore, high NEK2 expression was positively correlated with hepatic venous invasion (p=0.047), des-gammacarboxy prothrombin (p=0.003), and alpha-fetoprotein (AFP) (p=0.024). Patients with high NEK2 expression had significantly poor recurrence-free survival (p=0.042) and early recurrence. Overall, these results suggest that NEK2 could be a promising biomarker for HCC recurrence. (Keyword) Aged / Biomarkers, Tumor / Carcinoma, Hepatocellular / Disease-Free Survival / Female / Gene Expression Regulation, Enzymologic / Gene Expression Regulation, Neoplastic / Hepatectomy / Humans / Kaplan-Meier Estimate / Liver Neoplasms / Male / Middle Aged / Neoplasm Invasiveness / Neoplasm Recurrence, Local / Proportional Hazards Models / Protein-Serine-Threonine Kinases / Risk Factors / Time Factors / Treatment Outcome / Up-Regulation / 欧文論文 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26851035 ● Summary page in Scopus @ Elsevier: 2-s2.0-84979824116 (PubMed: 26851035, Elsevier: Scopus)
16.	Mandakhnaran Davaadorj, Satoru Imura, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Chie Takasu, Teraoku Hiroki, Masato Yoshikawa and Mitsuo Shimada : Loss of SFRP1 Expression Is Associated with Poor Prognosis in Hepatocellular Carcinoma., Anticancer Research, Vol.36, No.2, 659-664, Feb. 2016. (Summary) Secreted frizzled-related protein-1 (SFRP1) is a well-known inhibitor of the wingless type (WNT)-β-catenin signaling pathway and its inactivation plays an important role in the development and progression of various types of cancer. However, the clinical significance of SFRP1 expression in patients with hepatocellular carcinoma (HCC) remains unknown. A total of 63 patients with HCC who underwent hepatectomy at our Institution were enrolled in this study. A quantitative real-time polymerase chain reaction (RT-PCR) was performed to determine the SFRP1 mRNA expression level in both the tumorous and non-tumorous tissues of HCC. The patients were divided into low and high gene-expression groups based on the SFRP1 gene expression level in their tumor tissues. We analyzed the differences in clinicopathological characteristics between these two groups of patients. The expression level of SFRP1 was significantly lower in tumor tissue than in non-tumor tissue (p<0.0001). Significant correlations were observed between a high expression of SFRP1 in tumor tissue and older than 65 years (p=0.030), tumor size less than 5 cm (p=0.011); and no vascular invasion (p=0.004). Patients with high SFRP1 expression in tumor tissue had a significantly better overall survival rate (p=0.040). However, the SFRP1 expression level was not defined as an independent risk factor for patient survival based on results of multivariate analysis. SFRP1 may play a role in the development and progression of HCC. Therefore, more studies are required to investigate a potential role of SFRP1 in HCC prognosis. (Keyword) Adult / Aged / Aged, 80 and over / Biomarkers, Tumor / Carcinoma, Hepatocellular / Disease Progression / Disease-Free Survival / Down-Regulation / Female / Gene Expression Regulation, Neoplastic / Hepatectomy / Humans / Intercellular Signaling Peptides and Proteins / Kaplan-Meier Estimate / Liver Neoplasms / Male / Membrane Proteins / Middle Aged / Multivariate Analysis / Neoplasm Recurrence, Local / Proportional Hazards Models / Prospective Studies / RNA, Messenger / Real-Time Polymerase Chain Reaction / Risk Factors / Time Factors / Treatment Outcome / 欧文論文 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26851021 ● Summary page in Scopus @ Elsevier: 2-s2.0-84979837519 (PubMed: 26851021, Elsevier: Scopus)
17.	Gizachew Y. Wubetu, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Daichi Ishikawa, Shuichi Iwahashi, Shinichiro Yamada, Yu Saitou, Yusuke Arakawa and Satoru Imura : Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation., Journal of Gastroenterology and Hepatology, Vol.31, No.1, 256-264, Jan. 2016. (Summary) The long-term survival of patients with hepatocellular carcinoma remains unsatisfactory because of the presence of cancer stem cells (CSCs), which are responsible for tumor recurrence and chemoresistance after hepatectomy. Drugs that selectively target CSCs thus offer great promise for cancer treatment. Although the antitumor effects of epigallocatechin gallate (EGCG) have been reported in some cancer cells, its effects on CSCs remain poorly studied. In this study, we investigated the effects of EGCG on human hepatoma and colon CSCs. HepG2 and HCT-116 cell lines were enriched by sphere formation, and their gene-expression profiles were analyzed by quantitative real-time polymerase chain reaction. EGCG-induced growth inhibition in the parental cells was determined by WST-8 assay, and protein expression was assessed by western blotting. Cell cycle profile and apoptosis analysis was performed using flow cytometer. Sphere-derived cells grown in serum-free, nonadherent cultures showed increased expression of stem cell markers, Nek2, and ATP-binding cassette transporter genes, compared with parental cells grown in conventional culture. EGCG induced growth inhibition in the parental cells in a dose-dependent manner. EGCG also inhibited self-renewal in hepatoma and colon CSCs, attenuated the expression of stem cell markers and ATP-binding cassette transporter genes, which are putative molecules associated with treatment resistance in CSCs, and decreased the transcription of Nek2 and p-Akt, resulting in the inhibition of Akt signaling. EGCG also altered cell cycle profile and apoptosis, which may in part play an important role in EGCG-induced cancer cell death. Overall, these results suggest that EGCG could be a useful chemopreventive agent for targeting hepatocellular carcinoma and colon CSCs, in combination with standard chemotherapies. (Link to Publication Site) ● Publication site (DOI): 10.1111/jgh.13069 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26241688 ● Search Scopus @ Elsevier (PMID): 26241688 ● Search Scopus @ Elsevier (DOI): 10.1111/jgh.13069 (DOI: 10.1111/jgh.13069, PubMed: 26241688)
18.	Hiroki Teraoku, Yusuke Arakawa, Masato Yoshikawa, Shinichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : Complication of portal vein thrombosis after right hemihepatectomy in a patient lacking the portal vein bifurcation., The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 315-318, 2016. (Summary) Absence of portal vein bifurcation is a rare anomaly. We report a patient with this anomaly who underwent right hemihepatectomy for treatment of hepatocellular carcinoma. Although the procedure was carefully performed with a preoperative three-dimensional simulation and intraoperative cholangiography, postoperative portal vein thrombosis occurred. J. Med. Invest. 63: 315-318, August, 2016. (Keyword) Hepatectomy / Humans / Male / Middle Aged / Portal Vein / Postoperative Complications / Venous Thrombosis (Tokushima University Institutional Repository) ● Metadata: 111201 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.63.315 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644579 ● Search Scopus @ Elsevier (PMID): 27644579 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.63.315 (Tokushima University Institutional Repository: 111201, DOI: 10.2152/jmi.63.315, PubMed: 27644579)
19.	Yu Saitou, Sonoko Yasui, Yasuhiro Hamada, Chie Takasu, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 肝胆膵手術例の術前栄養管理, Surgery, Vol.76, No.11, 1201-1209, Nov. 2014.
20.	Yuji Morine, Mitsuo Shimada, Hiroki Ishibashi, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : 【膵・胆管合流異常の診断基準の改訂をめぐって】膵・胆管合流異常の診断の最前線胆汁中アミラーゼ値, Journal of Biliary Tract & Pancreas, Vol.35, No.10, 921-925, Oct. 2014. (Keyword) 和文論文
21.	Yu Saitou, Mitsuo Shimada, Hiroki Ishibashi, Yuji Morine, Satoru Imura, Hiroki Mori, Yusuke Arakawa, Shuichi Iwahashi and Chie Takasu : 【肝胆膵・術後病態を學ぶ】膵胆管合流異常・先天性胆道閉鎖症術後膵胆管合流異常術後発癌の特徴, KAN TAN SUI, Vol.69, No.1, 37-49, Jul. 2014. (Keyword) 和文論文
22.	Tohru Utsunomiya, Mitsuo Shimada, Yuji Morine, Atsushi Tajima and Issei Imoto : Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis., Cancer Science, Vol.105, No.7, 749-754, Jul. 2014. (Summary) Hepatocellular carcinoma (HCC) is one of the most common human cancers and a major cause of cancer-related death worldwide. The bleak outcomes of HCC patients even after curative treatment have been, at least partially, attributed to its multicentric origin. Therefore, it is necessary to examine not only tumor tissue but also non-tumor liver tissue to investigate the molecular mechanisms operating during hepatocarcinogenesis based on the concept of "field cancerization". Several studies previously investigated the association of molecular alterations in non-tumor liver tissue with clinical features and prognosis in HCC patients on a genome-wide scale. In particular, specific alterations of DNA methylation profiles have been confirmed in non-tumor liver tissue. This review focuses on the possible clinical value of array-based comprehensive analyses of molecular alterations, especially aberrant DNA methylation, in non-tumor liver tissue to clarify the risk of hepatocarcinogenesis. Carcinogenetic risk estimation based on specific methylation signatures may be advantageous for close follow-up of patients who are at high risk of HCC development. Furthermore, epigenetic therapies for patients with chronic liver diseases may be helpful to reduce the risk of HCC development because epigenetic alterations are potentially reversible, and thus provide promising molecular targets for therapeutic intervention. (Link to Publication Site) ● Publication site (DOI): 10.1111/cas.12431 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24766251 ● Summary page in Scopus @ Elsevier: 2-s2.0-84904333634 (DOI: 10.1111/cas.12431, PubMed: 24766251, Elsevier: Scopus)
23.	Yuji Morine, Mitsuo Shimada and Hiroki Ishibashi : 【膵・胆管合流異常の最前線】全国集計からみた膵・胆管合流異常, 日本消化器病学会雑誌, Vol.111, No.4, 699-705, Apr. 2014. (Keyword) 和文論文
24.	C Enkhbold, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, S Yamada, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : One-stop shop for 3-dimensional anatomy of hepatic vasculature and bile duct with special reference to biliary image reconstruction., Hepato-Gastroenterology, Vol.60, No.128, 1861-1864, Nov. 2013. (Summary) Three-dimensional CT has become an essential tool for successful hepatic surgery. Up to now, efforts have been made to simultaneously visualize hepatic vasculature and bile ducts. Herein, we introduce a new one-stop shop approach to hepatic 3D-anatomy, using a standard enhanced MDCT alone. A 3D-reconstruction of hepatic vasculature was made using data from contrast enhanced MDCT and SYNAPSE VINCENT software. We identified bile ducts from axial 2D image, and then reconstructed the 3D image. Both hepatic vasculature and bile duct images were integrated into a single image and it was compared with the 3D image, utilized with MRCP or DIC-CT. The first branches of both the right and left hepatic ducts were hand-traced and visualized for all 100 cases. The second branches of these ducts were visualized in 69 cases, and only the right second branch was recognized in 52 cases. Anomalous variations of bile ducts, such as posterior branch joining into common hepatic duct, were recognized in 12 cases. These biliary tract variations were all confirmed by MRCP or DIC-CT. Our new one-stop shop approach using the 3D imaging technique might contribute to successful hepatectomy as well as reduce medical costs and radiation exposure by omission of MRCP and DIC-CT. (Keyword) 英文論文 (Link to Publication Site) ● Publication site (DOI): 10.5754/hge13536 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24088317 ● Search Scopus @ Elsevier (PMID): 24088317 ● Search Scopus @ Elsevier (DOI): 10.5754/hge13536 (DOI: 10.5754/hge13536, PubMed: 24088317)
25.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Chie Takasu : Effects of splenectomy on hepatic gene expression profiles after massive hepatectomy in rats., Journal of Gastroenterology and Hepatology, Vol.28, No.10, 1669-1677, Oct. 2013. (Summary) Possible spleno-hepatic relationships affected by hepatectomy still remained unclear. We have previously reported that splenectomy may ameliorate liver injuries and promote appropriate liver regeneration after massive hepatectomy. Therefore, we investigated the effects of splenectomy on the DNA expression profile in the liver after massive hepatectomy in rats. Rats were divided into the following two groups: 90% hepatectomy (Hx group) and 90% hepatectomy with splenectomy (Hx + Sp group). Rats were sacrificed 3 and 6 h after surgery, and mRNA from liver tissue was isolated and hybridized to Affymetrix GeneChip Rat Genome 230 2.0 Array (Affymetrix, Santa Clara, CA, USA) and a pathway analysis was done with Ingenuity Pathway Analysis (Ingenuity Systems, Mountain View, CA, USA). We determined the Hx + Sp/Hx ratio to assess the influence of splenectomy, and cut-off values were set at more than 2.0-fold or less than 1/2 (0.5)-fold. Immediate early response gene including early growth response-1 and FBJ murine osteosarcoma-related pathways were markedly downregulated by splenectomy. In contrast, heme oxygenase-1 gene-related pathway was upregulated by splenectomy. Splenectomy provided the protective effects for liver failure and promoted liver regeneration, possibly owing to the downregulation of immediate early response genes and upregulation of the heat shock protein, heme oxygenase-1. (Keyword) 英文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/jgh.12316 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23808869 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897611157 (DOI: 10.1111/jgh.12316, PubMed: 23808869, Elsevier: Scopus)
26.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, Chie Takasu and Hidenori Miyake : 【各種デバイスを応用した私の手術―使用法と工夫】各種デバイスを応用した肝・胆手術, Surgery, Vol.75, No.9, 954-959, Sep. 2013. (Keyword) 和文論文
27.	Hiroki Mori, Mitsuo Shimada, Hiroki Ishibashi, Yuji Morine and 矢田圭吾 : 【膵・胆管合流異常アップデート】膵・胆管合流異常の全国集計成人の特徴, Japanese Journal of Pediatric Surgery, Vol.45, No.6, 614-616, Aug. 2013. (Keyword) 和文論文
28.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Toru Utsunomiya, Yuji Morine, Yusuke Arakawa and Mami Kanamoto : 【いつ何が大事かがわかる消化器外科術後の看護ポイント】腹腔鏡下胆嚢摘出術後の看護・観察ポイント 0∼12時間，12∼24時間，24∼72時間, Gastroenterological Surgery Nursing, Vol.18, No.8, 696-704, Aug. 2013. (Keyword) 和文論文
29.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto and Shuichi Iwahashi : 【大腸癌肝転移up to date】大腸癌肝転移化学療法後の肝障害, Surgery, Vol.75, No.8, 828-833, Aug. 2013. (Keyword) 和文論文
30.	T Toshima, Mitsuo Shimada, Toru Ikegami, Toru Utsunomiya, Tetsuya Ikemoto, Yuji Morine, Tomoharu Yoshizumi, Yuji Soejima, K Shirabe and Y Maehara : Fairly rare spontaneous disappearance of a hepatic artery aneurysm following living donor liver transplantation., Liver Transplantation, Vol.19, No.8, 929-930, Aug. 2013. (Keyword) 英文論文 (Link to Publication Site) ● Publication site (DOI): 10.1002/lt.23676 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23696536 ● Summary page in Scopus @ Elsevier: 2-s2.0-84881102318 (DOI: 10.1002/lt.23676, PubMed: 23696536, Elsevier: Scopus)
31.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto and Hiroki Mori : Significance of sonic hedgehog signaling after massive hepatectomy in a rat., Surgery Today, Vol.43, No.3, 300-307, Jun. 2013. (Summary) To clarify the functional involvement of hedgehog signaling, especially sonic hedgehog (Shh) and glioma-associated oncogene (Gli)-1 which are known to play an important role in embryonic development and cancer, in the regeneration of a hepatectomized rat liver. Six-week-old male Wistar rats were subjected to 70 or 90 % hepatectomy (Hx). Animals were killed at 24, 48 and 72 h after Hx. The liver/body weight ratio was measured as an index of regeneration. Formalin-fixed liver samples were embedded in paraffin, stained for immunohistochemistry with proliferating cell nuclear antigen (PCNA) antibody, and the labeling index was calculated. Immunohistochemistry was also performed with Shh and Gli-1 antibodies. The liver/body weight ratio gradually increased in both the 70 and 90 % Hx, groups. The hepatocytes were strongly stained for PCNA at 24 h after Hx. Non-parenchymal cells were gradually stained by PCNA from 24 to 72 h after Hx. Shh and Gli-1 expression in hepatocytes was higher after 24 h than at other times and then gradually decreased. Shh and Gli-1 expression in non-parenchymal cells increased gradually, and was found mainly in liver zone I at 72 h after 70 and 90 % Hx. The expression of both markers suggested that Shh signaling contributes to tissue reconstruction after Hx. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-012-0248-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22790641 ● Search Scopus @ Elsevier (PMID): 22790641 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0248-z (DOI: 10.1007/s00595-012-0248-z, PubMed: 22790641)
32.	Yuji Morine, Mitsuo Shimada, H Takamatsu, T Araida, I Endo, M Kubota, A Toki, T Noda, T Matsumura, S Miyakawa, Hiroki Ishibashi, T Kamisawa and H Shimada : Clinical features of pancreaticobiliary maljunction: update analysis of 2nd Japan-nationwide survey., Journal of Hepato-Biliary-Pancreatic Sciences, Vol.20, No.5, 472-480, Jun. 2013. (Summary) Pancreaticobiliary maljunction (PBM) is a congenital anomaly, which can be defined as a union of the pancreatic and biliary ducts located outside off the duodenal wall. We herein investigate clinical features of PBM including as the 2nd report of a Japanese nationwide survey. During a period of 18 years (from 1990 to 2007), 2,561 patients with PBM were registered at 141 medical institutions in Japan. Among them, eligible patients (n = 2,529) were divided into two groups: adult (n = 1,511) and pediatric patients (n = 1,018). Comparisons of clinical features including associated biliary cancers were performed according to the biliary dilatation (BD), age factor, and time era. Only one case in pediatric patients with BD combined with a bile duct cancer (0.1 %). In adult patients, the bile duct cancer and the gallbladder cancer was seen in 6.9 and 13.4 % patients with BD and in 3.1 and 37.4 % patients without BD, respectively. In adult patients with BD, the occurrence rates of biliary cancers were increased in latter period (00'-07') compared with former period (90'-99'). The ratio of biliary cancer localization was changed between former and latter period, and the bile duct cancer was increased in latter period (from 5.5 to 9.3 %). The largest series of PBM were evaluated to clarify the clinical features including the associated biliary cancer in this Japan-nationwide survey. This report could be widely used in the future as a reference data for diagnosis and treatment of PBM. (Keyword) 英文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00534-013-0606-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23579999 ● CiNii @ National Institute of Informatics (CRID): 1523951030185921920 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878981958 (DOI: 10.1007/s00534-013-0606-2, PubMed: 23579999, CiNii: 1523951030185921920, Elsevier: Scopus)
33.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司 and Yoshimi Bando : Oxaliplatin-related sinusoidal obstruction syndrome mimicking metastatic liver tumors., Hepatology Research, Vol.43, No.6, 685-689, Jun. 2013. (Summary) A 40-year-old woman who had undergone a curative low anterior resection for advanced rectal cancer was admitted to our hospital. She had been administrated oxaliplatin-based chemotherapy as postoperative adjuvant chemotherapy. The contrast-enhanced computed tomography revealed three hypovascular tumors, 3.0, 1.5 and 1.0 cm in diameter, located in the right hepatic lobe. The hepatocyte phase of the gadoxetic acid-enhanced magnetic resonance imaging demonstrated these lesions as hypointense tumors relative to the surrounding hepatic parenchyma. All these findings of the preoperative imaging modalities were compatible to metastatic liver tumors from the rectal cancer, and right hepatic lobectomy was successfully performed. Histopathologically, the tumors revealed sinusoidal dilation and severe congestion outlined by atrophic hepatocyte trabeculae, which was known as peliosis hepatis. The perisinusoidal space of Disse was extensively dilated and contained many erythrocytes. Taking these findings into account, the hepatic tumors were considered to be the space-occupying lesions resulting from the sinusoidal obstruction syndrome. We herein report the first case of focal sinusoidal obstruction syndrome mimicking metastatic liver tumors. (Keyword) 英文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2012.01114.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23730707 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878770639 (DOI: 10.1111/j.1872-034X.2012.01114.x, PubMed: 23730707, Elsevier: Scopus)
34.	Shuichi Iwahashi, Toru Utsunomiya, Mitsuo Shimada, Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Yoshimi Bando : High expressions of cancer stem cell markers in cholangiolocellular carcinoma., Surgery Today, Vol.43, No.6, 654-660, Jun. 2013. (Summary) Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor. It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC. The subjects of this study were three patients with CLC and one patient with an intermediate type of combined hepatocellular cholangiocarcinoma (CHC). The cancer cell markers, CK7, CK19, and EMA, were evaluated immunohistochemically. Histological examination of the CLC revealed morphologically cholangiolar features and immunohistochemical examination revealed positivity for CD133, CD44, and EpCAM. On the other hand, in the intermediate type of CHC, only CD44 was positive, whereas CD133 and EpCAM were negative. CLC may have stronger features derived from HpSCs than an intermediate type of CHC. (Keyword) 英文論文 (Tokushima University Institutional Repository) ● Metadata: 115811 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-012-0437-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23192764 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878013011 (Tokushima University Institutional Repository: 115811, DOI: 10.1007/s00595-012-0437-9, PubMed: 23192764, Elsevier: Scopus)
35.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine and Tetsuya Ikemoto : 【最新肝胆膵脾手術アトラス】肝臓右下肝静脈存在下での肝切除術, Operation, Vol.67, No.6, 715-720, May 2013. (Keyword) 和文論文
36.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa and Mami Kanamoto : 【エキスパートが教える内視鏡外科手術・ポイントとなる解剖の理解】肝・胆・膵・脾の鏡視下手術肝癌に対する鏡視下手術腹腔鏡下肝部分切除術, Gastroenterological Surgery, Vol.36, No.5, 779-785, Apr. 2013. (Keyword) 和文論文
37.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, 山田眞一郎, Yuji Morine, Satoru Imura, Hiroki Mori, 杉本光司, Shuichi Iwahashi and 浅野間理仁 : The protective effect of adipose-derived stem cells against liver injury by trophic molecules., The Journal of Surgical Research, Vol.180, No.1, 162-168, Mar. 2013. (Summary) In this study we investigated whether adipose-derived stem cells (ADSCs) had any beneficial protective effects on liver injury and regeneration in vivo. Moreover, we examined whether ADSCs protect hepatocytes via trophic molecules. We transplanted ADSCs into mice after 70% hepatectomy and ischemia-reperfusion, and observed liver injury and regeneration after reperfusion. We co-cultured hepatocytes with ADSCs using a Transwell system for 7 d and evaluated the viabilities of hepatocytes and the cytokine levels in the culture medium. Bevacizumab was used to confirm the effect of vascular endothelial growth factor (VEGF) on hepatocytes. ADSCs improved serum liver function at 6 h after reperfusion in a nonlethal model and stimulated liver regeneration at 24 h after reperfusion in a lethal model. VEGF levels in the culture medium were increased by co-culture ADSCs with hepatocytes. ADSCs improved the viabilities of hepatocytes. The inhibited production of VEGF by bevacizumab did not affect the viability of hepatocytes. ADSCs were able to ameliorate liver injury and stimulate liver regeneration in subsequent hepatectomy and ischemia-reperfusion-injured model mice. Furthermore, hepatocytes were protected by the trophic molecules of the ADSCs. However, such protective effects might be provided by mechanisms other than VEGF signaling. (Keyword) 英文論文 (Tokushima University Institutional Repository) ● Metadata: 105888 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jss.2012.10.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23117122 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873706630 (Tokushima University Institutional Repository: 105888, DOI: 10.1016/j.jss.2012.10.009, PubMed: 23117122, Elsevier: Scopus)
38.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 淺野間理仁, 山田眞一郎, 石川大地 and Hidenori Miyake : 【膵・胆管合流異常診療ガイドラインを巡る残された問題点】非拡張型膵・胆管合流異常の胆管癌発生頻度を巡る問題点, Journal of Biliary Tract & Pancreas, Vol.34, No.3, 241-244, Mar. 2013. (Keyword) 和文論文
39.	Tetsuya Ikemoto, Mitsuo Shimada, Shuichi Iwahashi, Yu Saitou, Mami Kanamoto, Hiroki Mori, Yuji Morine, Satoru Imura and Toru Utsunomiya : Changes of immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto/TJ-48) in patients with advanced pancreatic cancer., International Journal of Clinical Oncology, Vol.19, No.1, 81-86, Mar. 2013. (Summary) The prognosis of pancreatic cancer is extremely poor regardless of various combination therapies. Immunoaugumentation against tumor cells was recently A focus. We reported that the population of Foxp3(+)CD25(+)CD4(+) regulatory T cells (Foxp3(+)Treg) was the new parameter for the estimation of host immunity and had correlation with tumor aggressiveness. Here we show the immunoaugumentation effects of Japanese Kampo medicine, Juzen-Taihoto/TJ-48, empirically considered as an immunoaugumentation drug, with investigation of Treg and other immunological parameters. Peripheral Foxp3(+) Treg populations, CD4/CD8 ratio, and CD57(+) cells (NK cells) populations in advanced pancreatic cancer patients (n = 30, stage VI A and B according to TNM classification) were estimated after TJ-48 administration for 14 days before the anti-cancer therapy. Treg populations were significantly increased compared to healthy donors (Mann-Whitney U test, P < 0.001). Administration of Juzen-Taihoto/TJ-48 significantly decreased Treg populations (Mann-Whitney U test, P < 0.001) and increased the CD4/CD8 ratio (Mann-Whitney U test, P < 0.01), even though CD57(+) cell populations did not change significantly. Juzen-Taihoto/TJ-48 increased regulatory activities in T cells through decreasing Foxp3(+) Treg populations in advanced pancreatic cancer patients. This effect can lead to immunoaugumentation for various combination therapies. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-013-0529-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23443635 ● Summary page in Scopus @ Elsevier: 2-s2.0-84894563665 (DOI: 10.1007/s10147-013-0529-6, PubMed: 23443635, Elsevier: Scopus)
40.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, 山田眞一郎 and 浅野間理仁 : Regulatory T cells in the blood: a new marker of surgical stress., Surgery Today, Vol.43, No.6, 608-612, Jan. 2013. (Keyword) 英文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-013-0517-5 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573105975985904384 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-013-0517-5 (DOI: 10.1007/s00595-013-0517-5, CiNii: 1573105975985904384)
41.	Tetsuya Ikemoto, Mitsuo Shimada, Masato Komatsu, Shinichiro Yamada, Yu Saito, Hiroki Mori, Yuji Morine, Satoru Imura, Yoshimi Bando and Toru Utsunomiya : Indoleamine 2,3-dioxygenase affects the aggressiveness of intraductal papillary mucinous neoplasms through Foxp3+CD4+CD25+ T cells in peripheral blood., Pancreas, Vol.42, No.1, 130-134, Jan. 2013. (Summary) Intraductal papillary mucinous neoplasms (IPMNs) have a high malignant potential. We previously reported that peripheral Foxp3(+)CD4(+)CD25(+) T-cell (Foxp3(+) Treg) populations significantly increase with IPMN pathological aggressiveness. Dendritic cell-mediated induction of active Tregs from naive CD4(+) T cells requires indoleamine 2,3-dioxygenase (IDO). Here, we evaluated whether an IDO-Foxp3(+) Treg interaction plays a role in IPMN pathological aggressiveness. We evaluated peripheral blood samples and resected specimens from 12 patients with IPMN. We analyzed Foxp3(+)CD4(+)CD25(+) T cells in peripheral blood by fluorescence-activated cell sorting, evaluated the resected specimens by anti-IDO antibody staining, and compared them with the patients' clinicopathological factors. The pathological aggressiveness of IPMN was significantly associated with the number of peripheral Foxp3(+) Tregs (P < 0.05) and IDO-positive cells per high-power field (HPF) (P < 0.01). There was a significant correlation between the numbers of peripheral Foxp3(+) Tregs and IDO-positive cells/HPF (r = 0.625, P < 0.01). Patients with 7 or more IDO-positive cells/HPF had a significantly higher recurrence rate than those with less than 7 IDO-positive cells/HPF (P < 0.01, log-rank test). Peripheral Foxp3(+) Tregs accurately reflect the aggressiveness of IPMNs. An increase in Foxp3(+) Tregs can be induced by local IDO-positive cells in IPMN. (Keyword) Adenocarcinoma, Mucinous / Adenocarcinoma, Papillary / Aged / Aged, 80 and over / analysis of variance / Carcinoma, Pancreatic Ductal / cell separation / Disease-Free Survival / Female / Flow Cytometry / Forkhead Transcription Factors / Humans / immunohistochemistry / Indoleamine-Pyrrole 2,3,-Dioxygenase / Interleukin-2 Receptor alpha Subunit / Lymphatic Metastasis / Male / Middle Aged / Neoplasm Invasiveness / Neoplasm Recurrence, Local / Pancreatic Neoplasms / T-Lymphocytes, Regulatory / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1097/MPA.0b013e3182575e4a (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22722263 ● Summary page in Scopus @ Elsevier: 2-s2.0-84872079174 (DOI: 10.1097/MPA.0b013e3182575e4a, PubMed: 22722263, Elsevier: Scopus)
42.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 浅野間理仁 : Atypically large well-differentiated hepatocellular carcinoma with extensive fatty metamorphosis: report of a case., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 267-271, 2013. (Summary) A large well-differentiated hepatocellular carcinoma (HCC) with fatty change is rare, and to date only a few cases have been reported. Herein, we present a 68-year-old man who developed a well-differentiated HCC with extensive fatty metamorphosis. The patient was referred to our institute because of a rapidly growing tumor in the left lobe of the liver. Ultrasonography showed a hyperechoic lesion with a peripheral hypoechoic area. Dynamic contrast-enhanced computed tomography (CT) scan in all three phases revealed the tumor which showed diffuse low attenuation with internal irregular enhancement. He underwent left lateral segmentectomy at the liver. Histological diagnosis confirmed well-differentiated HCC and the surrounding non-cancerous area was diagnosed as non-alcoholic steatohepatitis. The patient is still alive without recurrence after 17 months of follow-up. (Keyword) 英文論文 (Tokushima University Institutional Repository) ● Metadata: 106367 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.60.267 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190046 ● Summary page in Scopus @ Elsevier: 2-s2.0-84886996013 (Tokushima University Institutional Repository: 106367, DOI: 10.2152/jmi.60.267, PubMed: 24190046, Elsevier: Scopus)
43.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁 and Hiroki Ishibashi : Hepatic epithelioid angiomyolipoma with arterioportal venous shunting mimicking hepatocellular carcinoma : report of a case., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 262-266, 2013. (Summary) A patient with hepatic epithelioid angiomyolipoma (Epi-AML) with arterioportal venous shunting, who was successfully treated by a laparoscopic left lateral sectionectomy, is presented herein. AML is an uncommon benign neoplasm of the liver. Tumors composed predominantly of epithelioid cells have been subcategorized into Epi-AML, and the treatment strategy for Epi-AML is currently undetermined. There are no reports describing Epi-AML with arterioportal venous shunting to date. An arterioportal venous shunting of the liver tumor was suggested to be one of the malignant signs of the liver tumor. It would be important to differentiate Epi-AML with arterioportal venous shunting from hepatocellular carcinoma and hypervascular metastatic tumors. Minimally invasive resection, such as laparoscopic hepatectomy, for patients having Epi-AML with arterioportal venous shunting may be recommended. (Keyword) Angiomyolipoma / Carcinoma, Hepatocellular / Diagnosis, Differential / Hepatic Artery / Humans / Liver Neoplasms / Magnetic Resonance Imaging / Male / Middle Aged / Portal Vein / Tomography, X-Ray Computed (Tokushima University Institutional Repository) ● Metadata: 106366 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.60.262 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190045 ● Search Scopus @ Elsevier (PMID): 24190045 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.60.262 (Tokushima University Institutional Repository: 106366, DOI: 10.2152/jmi.60.262, PubMed: 24190045)
44.	杉本光司, Toru Utsunomiya, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Chie Takasu and Mitsuo Shimada : Hand-assisted laparoscopic splenectomy for a huge splenic vascular lesion with aneurysms in a patient with impending Kasabach-Merritt syndrome-like phenomenon., The Journal of Medical Investigation : JMI, Vol.60, No.3-4, 276-279, 2013. (Summary) Splenic vascular lesions are relatively rare and are usually found incidentally. However, the vascular lesions associated with Kasabach-Merritt syndrome, such as hemangioma, can be life-threatening. We herein describe the case of a young adult female patient with a huge splenic vascular lesion, aneurysms of the splenic artery, and increased plasma levels of fibrin/fibrinogen degradation products and D-dimers. Hand-assisted laparoscopic splenectomy was performed, after which the coagulopathy was drastically improved. Minimally invasive surgical intervention such as hand-assisted laparoscopic splenectomy should be considered as the first treatment choice in such a case. (Keyword) 英文論文 (Tokushima University Institutional Repository) ● Metadata: 106369 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.60.276 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24190048 ● Summary page in Scopus @ Elsevier: 2-s2.0-84887005653 (Tokushima University Institutional Repository: 106369, DOI: 10.2152/jmi.60.276, PubMed: 24190048, Elsevier: Scopus)
45.	Shinichiro Yamada, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, Shuichi Iwahashi, Yu Saitou and Hiroki Ishibashi : Hilar cholangiocarcinoma accompanied by pancreaticobiliary maljunction without bile duct dilatation 20 years after cholecystectomy: report of a case, The Journal of Medical Investigation : JMI, Vol.60, No.1-2, 169-173, 2013. (Summary) Pancreaticobiliary maljunction (PBM) is associated with the occurrence of biliary cancer due to pancreatobiliary reflux. From the perspective of carcinogenesis, the treatment for PBM is controversial. We herein report a case of hilar cholangiocarcinoma 20 years after the occurrence of gallbladder cancer. A 75-year-old man was referred to our hospital regarding an obstructive jaundice and bile duct tumor. A cholecystectomy was performed for cholelithiasis on this patient 20 years ago, and cancer in situ was detected. Computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed a tumor of the portal hepatic region and PBM without dilatation of the bile duct. Adenocarcinoma was detected from bile cytology, and we diagnosed hilar cholangiocarcinoma. Despite the biliary decompression, jaundice was prolonged and the patient passed away. Our case suggests that not only cholecystectomy but also biliary diversion is needed for PBM regardless of the existence of bile duct dilatation. (Keyword) 欧文論文 (Tokushima University Institutional Repository) ● Metadata: 106060 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.60.169 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614928 ● Search Scopus @ Elsevier (PMID): 23614928 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.60.169 (Tokushima University Institutional Repository: 106060, DOI: 10.2152/jmi.60.169, PubMed: 23614928)
46.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Jun Hanaoka : Effects of a whey peptide-based enteral formula diet on liver dysfunction following living donor liver transplantation., Surgery Today, Dec. 2012. (Summary) BACKGROUND AND AIMS: Whey protein, a protein complex derived from milk is well known as a functional food with a number of health benefits. MEIN(®) (Meiji Dairies Co., Tokyo Japan) is a functional liquid-type nutritional diet containing whey-hydrolyzed peptide. In this study, we examined the effects of MEIN(®) on postoperative liver dysfunction in patients who underwent living donor-related liver transplantation (LDLT). METHODS: Sixteen adult patients transplanted between 2005 and 2011 at our institute were evaluated retrospectively. In MEIN group (n = 8), administration of MEIN(®) was started around 14 days after liver transplantation when serum liver enzymes were re-elevated, while MEIN(®) was not administered in the control group (n = 8) who did not have postoperative liver dysfunction. RESULTS: In the preoperative clinical characteristics, the model for end-stage liver disease score in the MEIN group was significantly lower than that in the control group. The graft-to-recipient body weight ratio in the MEIN group was lower than that in the control group. Elevation of enzymes in the liver function tests such as alanine aminotransferase and total bilirubin, and C-reactive protein in the MEIN group had significantly improved, and became almost normal values which were the same as those in the control group. CONCLUSION: These findings suggest that administration of whey-hydrolyzed peptide attenuates the post-transplant liver dysfunction and may avoid an unnecessary liver biopsy. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-012-0466-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23266751 ● Search Scopus @ Elsevier (PMID): 23266751 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0466-4 (DOI: 10.1007/s00595-012-0466-4, PubMed: 23266751)
47.	Mitsuo Shimada, 神澤輝実, 安藤久實, 須山正文, Yuji Morine and Hiroki Mori : 膵・胆管合流異常診療ガイドライン(日本膵・胆管合流異常研究会・日本胆道学会編), Journal of Japan Biliary Association, Vol.26, No.5, 678-690, Dec. 2012. (Keyword) 和文論文
48.	Masaaki Nishi, Mitsuo Shimada, Hideaki Uchiyama, Toru Ikegami, Yusuke Arakawa, Jun Hanaoka, 金村普史, Yuji Morine, Satoru Imura and Hidenori Miyake : The beneficial effects of Kampo medicine Dai-Ken-Chu-To after hepatic resection: a prospective randomized control study., Hepato-Gastroenterology, Vol.59, No.119, 2290-2294, Oct. 2012. (Summary) After hepatic resection, delayed flatus and impaired bowel movement often cause problematic postoperative ileus. Kampo medicine, Dai-kenchu-to (DKT), is reported to have a various beneficial effects on bowel systems. The aim of this study was to prospectively evaluate effects of DKT after hepatic resection. Thirty-two patients who underwent hepatic resection between July 2007 and August 2008 in Tokushima University Hospital were prospectively divided into DKT group (n=16) and control group (n=16). In DKT group, 2.5 g of DKT was administered orally three times a day from postoperative day (POD) 1. Blood was examined on POD 1, 3, 5 and 7. Postoperative first flatus, bowel movement and full recovery of oral intake, hospital stays and complications were checked. In DKT group, levels of c-reactive protein and beta-(1-3)-D-glucan on POD 3 were significantly decreased (p<0.05). Moreover, postoperative periods for the first flatus, bowel movement and the full recovery of oral intake were significantly shortened in DKT group (p<0.05). DKT suppressed inflammatory reaction, stimulated bowel movement and improved oral intake after hepatic resection, which may decrease serious morbidity after hepatic resection. (Keyword) Administration, Oral / Aged / Biological Markers / C-Reactive Protein / Chi-Square Distribution / Defecation / Drug Administration Schedule / Eating / Female / Flatulence / Gastrointestinal Transit / Hepatectomy / Humans / Ileus / Inflammation / Japan / Length of Stay / Male / Medicine, Kampo / Middle Aged / Plant Extracts / Prospective Studies / Recovery of Function / Time Factors / Treatment Outcome / beta-Glucans (Link to Publication Site) ● Publication site (DOI): 10.5754/hge10115 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23435143 ● Search Scopus @ Elsevier (PMID): 23435143 ● Search Scopus @ Elsevier (DOI): 10.5754/hge10115 (DOI: 10.5754/hge10115, PubMed: 23435143)
49.	Hiroki Mori, Mitsuo Shimada, Toru Ikegami, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Shuichi Iwahashi, 齋藤裕, 淺野間理仁, 山田眞一郎 and Hidenori Miyake : The Impact of Pegylated-Interferon alpha-2b on Partial and Massive Hepatectomy Model in Rats., Hepato-Gastroenterology, Vol.59, No.119, 2300-2304, Oct. 2012. (Summary) The impact of pegylated-interferon (PEG-IFN) α-2b on liver regeneration has not yet been elucidated. Rats were divided into the following four groups: 70% hepatectomy (Hx); 70% Hx+PEG-IFN; 90% Hx and 90% Hx+PEG-IFN group (n=6 each). Rats were pretreated with subcutaneous of PEGIFN α-2b (1.5 μg/kg) administration 24 hours before Hx. Samples were taken 24, 48 and 72 hours after Hx and the following parameters were investigated: blood analysis (AST, WBC, PLT); liver weight to body weight ratio (Lw/Bw ratio); survival and PCNA labeling index (LI). In the 90% Hx model, there was no significant difference between the Hx+PEG-IFN group and the Hx alone group in blood analysis; AST after postoperative 24 hours (2511 vs. 2466 IU/L), WBC (1200 vs. 1290) and PLT (107 vs. 111 x 104/mm³), in Lw/Bw ratio at postoperative 0, 24, 48, 72 hours, respectively (0.38, 0.60, 1.14, 1.69 vs. 0.37, 0.64, 1.12, 1.63), in postoperative survival (40% vs. 45%), and in PCNA LI at postoperative 0, 24, 48, 72 hours, respectively (10.4%, 16.8%, 14.6%, 12.8% vs. 10.0%, 17.1%, 15.6%, 13.7%). In the 70% Hx model, there was no significant difference between the Hx+PEG-IFN group and the Hx alone group for all parameters. Our data demonstrated that PEG-IFN α-2b did not affect liver regeneration and the early use of PEG-IFN α-2b would cause no problems after liver transplantation using partial grafts including living donor liver transplantation. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.5754/hge10401 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23435145 ● Search Scopus @ Elsevier (PMID): 23435145 ● Search Scopus @ Elsevier (DOI): 10.5754/hge10401 (DOI: 10.5754/hge10401, PubMed: 23435145)
50.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 山田眞一郎 and 淺野間理仁 : Prediction of recurrence of hepatocellular carcinoma after curative hepatectomy using preoperative Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein., Hepatology Research, Vol.42, No.9, 887-894, Sep. 2012. (Summary) Aim: Lens culinaris agglutinin A-reactive fraction of α-fetoprotein (AFP-L3) status has been reported to be an independent prognostic factor in patients with hepatocellular carcinoma (HCC). In this study, we evaluated the clinical usefulness of measuring preoperative AFP-L3 to predict the recurrence and prognosis of HCC after curative hepatectomy. Methods: One hundred and forty-two HCC patients who underwent curative hepatectomy were examined for the correlation between preoperative tumor marker, including AFP, des-γ-carboxy prothrombin (DCP) and AFP-L3, and clinicopathological variables. The prognostic factors of disease-free survival rates and overall survival rates were also determined using clinicopathological variables including these three tumor markers. Results: There were similar tendencies in the relationship between these three markers and malignant behaviors including lower grade tumor differentiation or vascular invasion. In multivariate analysis, increased AFP-L3 value (P = 0.019) was found to be an independent prognostic factor of disease-free survival after curative hepatectomy. In addition, elevated DCP (P = 0.013) and AFP-L3 values (P = 0.012) were found to be independent prognostic factors. Furthermore, the preoperative AFP-L3 value in the patients with early recurrence (within 1 year after hepatectomy) was significantly higher than that in those without early recurrence (26.9 ± 19.5 % vs 14.2 ± 19.8 %, P = 0.047). Conclusion: Preoperative AFP-L3 value was strongly correlated to disease-free and overall survival rate and the timing of recurrence, so it appears that it would be useful to predict the recurrence and prognosis of HCC after curative hepatectomy. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2012.01004.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22524419 ● Search Scopus @ Elsevier (PMID): 22524419 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1872-034X.2012.01004.x (DOI: 10.1111/j.1872-034X.2012.01004.x, PubMed: 22524419)
51.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, Shuichi Iwahashi and 齋藤裕 : Surgical results of pancreatoduodenectomy in elderly patients., Surgery Today, Vol.42, No.9, 857-862, Sep. 2012. (Summary) To assess the safety and feasibility of pancreatoduodenectomy (PD) in elderly patients, we investigated the clinical characteristics of patients aged ≥75 years, who underwent this procedure at our hospital. Between November 2005 and December 2010, 84 patients underwent PD at Tokushima University Hospital. We analyzed the clinicopathological data and outcomes after PD in patients aged ≥75 years compared with those in patients <75 years. The preoperative characteristics of the elderly group (n = 28) were similar to those of the younger group (n = 56). The hemoglobin and albumin levels were significantly lower in the elderly patients (P < 0.05), who also had a higher rate of preoperative pulmonary dysfunction (P < 0.05). The operation time and intraoperative blood loss did not differ significantly between the groups, but the incidence of pneumonia was higher in the elderly group (P < 0.05). The overall survival rate did not differ significantly between the groups. Advanced age alone does not have an adverse effect on surgical outcomes, including postoperative complications and long-term prognosis. Therefore, PD may be justified for selected elderly patients. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-012-0169-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22447454 ● Search Scopus @ Elsevier (PMID): 22447454 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0169-x (DOI: 10.1007/s00595-012-0169-x, PubMed: 22447454)
52.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, 齋藤裕, Shuichi Iwahashi, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto and Yuji Morine : Impact of a new refrigerator on the preservation of hepatic grafts., Hepatology Research, Vol.42, No.8, 798-805, Aug. 2012. (Summary) Aim: Current medical transplantation methods focus on solutions for major problems such as the shortage of donors. To overcome these issues, expanding organ preservation time has become a major concern. A new refrigerating chamber has been recently developed, which can cool the inside of a material to the required temperature by frequently sensing the temperature of both inside and surface of the materials. The purpose of this study is to evaluate the usefulness of a new refrigerating system in hepatic preservation. Methods: The liver grafts were harvested from rats and divided into two groups. Group A consisted of grafts preserved in chilled University of Wisconsin solution (UW) solution (on ice) for 24, 72 and 168 h. Group B consisted of grafts preserved in the UW solution in a new refrigerator at 4°C. Results: In group B, aspartate aminotransferase released into effluent after cold storage for 72 h showed a marked decrease compared to group A (P < 0.05). The levels of ammonia and lactate decreased significantly in group B (P < 0.05). In group B, the levels of adenosine triphosphate were significantly preserved after cold storage for 24 h and 72 h compared to group A (P < 0.05). Immunohistochemistry showed positive cells for heme oxygenase-1 were significantly increased in group B after cold storage. Conclusion: This new refrigerator can improve preservation injury of hepatic grafts and may provide an innovative technique for liver transplantation. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2012.00987.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22469252 ● Search Scopus @ Elsevier (PMID): 22469252 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1872-034X.2012.00987.x (DOI: 10.1111/j.1872-034X.2012.00987.x, PubMed: 22469252)
53.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, 齋藤裕 and Hidenori Miyake : A Modified liver-hanging maneuver focusing on the ligamentum venosum in left hepatic lobectomy, Surgery Today, Vol.42, No.8, 720-723, Aug. 2012. (Summary) The liver-hanging maneuver (LHM) is a useful technique in major hepatectomy. We made modifications to this technique with special reference to the ligamentum venosum for performing a left hepatectomy (LH). The aim of this study was to clarify the usefulness of our new technique. Between August 2007 and May 2009, five patients underwent LH using our modified LHM and 12 patients underwent LH using a conventional procedure. The two groups were compared in terms of the patient characteristics, preoperative hepatic functions, surgical records, and outcomes. The characteristics and preoperative hepatic function tests were similar between the modified LHM and non-LHM groups. Intraoperative blood loss was significantly reduced in the modified LHM group compared with the non-LHM group (193 ± 133 vs. 375 ± 167 ml, P < 0.05). The lengths of the operations and time required to perform a parenchymal transection did not differ significantly between the two groups (duration of operations 273 ± 37 vs. 337 ± 70 min; transection times 29 ± 10 vs. 28 ± 13 min). The postoperative complications and hospital stays did not differ significantly between the two groups. Our modified LHM can reduce the intraoperative blood loss during LH, and our results have shown the usefulness of this modified technique for LH. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-011-0051-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22094437 ● Search Scopus @ Elsevier (PMID): 22094437 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-011-0051-2 (DOI: 10.1007/s00595-011-0051-2, PubMed: 22094437)
54.	T Kamisawa, H Ando, M Suyama, Mitsuo Shimada, Yuji Morine, H Shimada and Working Committee of Clinical Practice Guidelines for Pancreaticobiliary Maljunction; Japanese Study Group on Pancreaticobiliary Maljunction. : Japanese clinical practice guidelines for pancreaticobiliary maljunction., Journal of Gastroenterology, Vol.47, No.7, 731-759, Jul. 2012. (Summary) There have been no clinical guidelines for the management of pancreaticobiliary maljunction (PBM). The Japanese Study Group on Pancreaticobiliary Maljunction (JSPBM) has proposed to establish clinical practice guidelines on how to deal with PBM, with the support of the Japan Biliary Association (JBA). Because the body of evidence-based literature is relatively small, we decided to create guidelines based on the consensus of experts, using the medical literature for reference. A total of 46 clinical questions (CQs) were considered by the members of the editorial committee responsible for the guidelines. The CQs covered distinct aspects of PBM: (1) Concepts and Pathophysiology (10 CQs); (2) Diagnosis (10 CQs); (3) Pancreatobiliary complications (9 CQs); and (4) Treatments and prognosis (17 CQs). Statements and comments for each CQ were prepared by the guidelines committee members and collaborating partners. The CQs were completed after review by members of the editorial committee, meetings of this committee, public comments on the homepages of the JSPBM and the JBA, public hearings, and assessment and approval by the guidelines evaluation board. PBM includes cases where the bile duct is dilated (PBM with biliary dilatation) and those in which it is not (PBM without biliary dilatation). In these guidelines, PBM with biliary dilatation is defined as being identical to congenital biliary dilatation of Todani type I (except for type Ib) and type IV-A, both of which are accompanied by PBM in almost all cases. These guidelines are created to provide assistance in the clinical practice of PBM management; their contents focus on clinical utility, and they include general information on PBM to make this disease more widely recognized. (Keyword) Bile Duct Diseases / Bile Ducts / Evidence-Based Medicine / Humans / Japan / Pancreatic Diseases / Pancreatic Ducts / Prognosis (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-012-0611-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22722902 ● Search Scopus @ Elsevier (PMID): 22722902 ● Search Scopus @ Elsevier (DOI): 10.1007/s00535-012-0611-2 (DOI: 10.1007/s00535-012-0611-2, PubMed: 22722902)
55.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Hiroki Mori : Huge focal nodular hyperplasia difficult to distinguish from well-differentiated hepatocellular carcinoma, Hepatology Research, Vol.42, No.7, 727-731, Jul. 2012. (Summary) We present a 43-year-old man with huge focal nodular hyperplasia (FNH) that was difficult to distinguish from well-differentiated hepatocellular carcinoma (HCC). He previously had abnormal portal vein circulation due to hypoplasia of the intrahepatic portal vein, which was treated with a superior mesenteric vein-inferior vena cava shunt. Laboratory findings included predominantly indirect hyperbilirubinemia with concomitant elevation in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and ammonia. Serum α-fetoprotein and des-γ-carboxy prothrombin were slightly elevated. Multidetector-row computed tomography detected the primary tumor in the left liver lobe, which partially showed a central stellate scar. Gd ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging showed some low-intensity areas in the tumor in the hepatocyte phase. 99mTc-galactosyl human serum albumin scintigraphy showed normal intake of agent in the tumor. We could not rule out well-differentiated HCC. Extended left hepatectomy was performed. Final histopathological findings showed that most of the tumor was FNH against a background of portal vein hypoplasia with moderate atypia and hemorrhage. And immunohistochemical analysis revealed high expression of organic anion transporter (OATP) 1B3 and low expression of multidrug resistance-associated protein (MRP) 2 in a part of the tumor. The patient has remained alive with no hepatic lesion for 1 year after surgery. We describe a case of huge FNH that was difficult to distinguish from well-differentiated HCC even by current fully preoperative imaging technology and demonstrate the effectiveness of curative surgical resection. (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2012.00974.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22686861 ● Search Scopus @ Elsevier (PMID): 22686861 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1872-034X.2012.00974.x (DOI: 10.1111/j.1872-034X.2012.00974.x, PubMed: 22686861)
56.	LO Tovuu, Satoru Imura, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 淺野間理仁, Hidenori Miyake and Mitsuo Shimada : Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma., International Journal of Clinical Oncology, Vol.18, No.4, 651-656, Jun. 2012. (Summary) CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion, and cell migration. We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC). Forty-eight patients with HCC who underwent hepatic resection at our institution were enrolled in this study. CD44 expressions in both tumor and non-tumor tissues were examined using real time reverse transcription-polymerase chain reaction. The patients were divided into two groups: high and low gene-expression group, based on the CD44 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues. In the tumor tissues, the gene-expression levels of CD44 did not correlate with any clinicopathological parameters. The disease-free survival rate showed no significant difference between the two groups. In non-tumor tissues, although there was no significant relationship between the CD44 expression levels and clinicopathological factors, disease-free survival rate in the CD44 low expression group was significantly better than that in the CD44 high expression group (P < 0.05). In multivariate analysis, the risk factors in tumor recurrence were presence of microscopic portal invasion and high expression level of CD44. The CD44 expressions in the non-tumor tissues may predict HCC recurrence. (Tokushima University Institutional Repository) ● Metadata: 106069 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-012-0432-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22706704 ● Search Scopus @ Elsevier (PMID): 22706704 ● Search Scopus @ Elsevier (DOI): 10.1007/s10147-012-0432-6 (Tokushima University Institutional Repository: 106069, DOI: 10.1007/s10147-012-0432-6, PubMed: 22706704)
57.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori and Jun Hanaoka : Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma, Surgery Today, Vol.42, No.6, 565-569, Jun. 2012. (Summary) Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes in the metabolism of 5-fluorouracil, which have been examined as possible predictive markers. We conducted this study to clarify the role of TS and DPD expressions in gallbladder carcinoma (GBC). The subjects were 28 patients who underwent surgical resection of GBC. We examined intratumoral TS and DPD mRNA expressions, using the Danenberg tumor profile method. The expression levels were classified into two groups, based on median values. Clinicopathological variables, including prognosis, were then compared between the high and low expression groups. There was a significant difference in the incidence of lymph node metastasis between the high and low TS expression groups. The incidence of advanced clinical stage was higher in the low TS expression group than in the high TS expression group. However, no clear correlation was observed between the DPD mRNA expression and any clinicopathological variable. There was no significant difference in the postoperative survival rates between the groups, in accordance with the expression of TS or DPD genes. Low TS mRNA was correlated with a high incidence of lymph node metastasis and advanced clinical stage. Therefore, TS gene expression may help identify patients at increased risk of the progression of GBC. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00595-012-0118-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22270332 ● Search Scopus @ Elsevier (PMID): 22270332 ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0118-8 (DOI: 10.1007/s00595-012-0118-8, PubMed: 22270332)
58.	Satoru Imura, Mitsuo Shimada, 齋藤裕, Shuichi Iwahashi, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Toru Utsunomiya : Successful case with hemophagocytic syndrome after living donor liver transplantation., Hepato-Gastroenterology, Vol.59, No.115, 863-865, May 2012. (Summary) Hemophagocytic syndrome (HPS) is a rare but serious complication that is associated with hypercytokinemia caused by activated T lymphocytes and macrophages in immunologically compromised patients. Living donor liver transplantation (LDLT) between adults has been performed to compensate for the shortage of available organs. There have been some reports of HPS after LDLT but its prognosis is disappointingly poor. Herein, we report a case of HPS in a 53-year-old woman who underwent LDLT using a left lobe graft. HPS was diagnosed on postoperative day 6 and successfully treated with a steroid pulse. HPS is a fatal complication in immunologically compromised patients but its early diagnosis and appropriate treatment can lead to an improved outcome. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.5754/hge10081 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22469732 ● Search Scopus @ Elsevier (PMID): 22469732 ● Search Scopus @ Elsevier (DOI): 10.5754/hge10081 (DOI: 10.5754/hge10081, PubMed: 22469732)
59.	山田眞一郎, Mitsuo Shimada, Hidenori Miyake, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi and 齋藤裕 : Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma., Hepatology Research, Vol.42, No.5, 454-458, May 2012. (Summary) Aim: The aim of this study was to investigate the characteristics of super-elderly hepatocellular carcinoma (HCC) patients aged 80 years or more who underwent hepatectomy and to clarify whether elderly patients with HCC benefit from hepatectomy. Methods: Between March 1992 and December 2008, 278 patients who underwent curative hepatectomy for HCC were investigated. Super-elderly patients were defined as those aged 80 years or more. Clinicopathological data and outcomes after hepatectomy were compared between super-elderly and non-super-elderly groups. Results: Preoperative parameters, such as biochemical examinations, and liver function tests in the non-super-elderly group were comparable with those of the super-elderly group (n = 11). Exceptionally, albumin level in the super-elderly group was lower than that in the non-super-elderly group (P = 0.03). Surgical data and the prevalence of postoperative complications did not differ significantly between the two groups. No mortality was observed in the super-elderly and non-super-elderly group. Conclusions: Hepatectomy for HCC was a feasible option even in super elderly patients aged 80 years or older with accurate selection. (Keyword) 欧文論文 (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1872-034X.2011.00952.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22295877 ● Search Scopus @ Elsevier (PMID): 22295877 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1872-034X.2011.00952.x (DOI: 10.1111/j.1872-034X.2011.00952.x, PubMed: 22295877)
60.	Horohiko Sato, Mitsuo Shimada, Nobuhiro Kurita, Yuji Morine, Kouzou Yoshikawa, 稲葉一樹 and 宇山一朗 : Robot-assisted distal gastrectomy using the da Vinci Surgical System, Shikoku Acta Medica, Vol.68, No.1-2, 53-58, Apr. 2012. (Summary) The da Vinci Surgical System is a telerobotic system consisting of4components, including theInsite vision system with a true3‐dimensional endoscope providing a high-resolution binocular view ofthe surgical field, and the Endo Wrist instrument system, which is capable of7degrees of freedomand2degrees of axial rotation to replicate human wrist-like movements. Distal gastrectomy andD1+lymphnode dissection was performed in a73-year-old man with cT1bN0N0StageIA gastriccancer. Preoperative abdominal CT findings were showed that celiac artery branching patternswas Adachi VI type26groups. The operating time was433minutes, and the blood loss was284g.The da Vinci Surgical System has useful advantages over conventional Laproscopic Assisted gastrectomy(LAG)surgery concerning the precise lymphnodes dissection. With further innovationsin the future, the da Vinci Surgical System has the potential to facilitate technically difficult surgeryemploying conventional LAG techniques. (Keyword) 和文論文 (Tokushima University Institutional Repository) ● Metadata: 97918 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812711312256 (Tokushima University Institutional Repository: 97918, CiNii: 1050282812711312256)
61.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, 齋藤裕 and 淺野間理仁 : Hepatic screlosed hemangioma which was misdiagnosed as metastasis of gastric cancer: report of a case, The Journal of Medical Investigation : JMI, Vol.59, No.3-4, 270-274, 2012. (Summary) A screlosed hemangioma of the liver is rare among hepatic tumors. A 75 years old male was referred to our hospital for gastric cancer and a hepatic tumor. The histological finding of gastric cancer was revealed to be well differentiated adenocarcinoma. The liver tumor was 1.1×1.0 cm in size and located in segment 8 of the liver. Computed tomography (CT) showed it to be a tumor with ring enhancement. Magnetic resonance imaging (MRI) showed the tumor to have a low signal on T1-weighted and slightly high signal on T2-weighted images. Level of hemoglobin was 7.8 g/dl. It was thought to be persistent bleeding from gastric cancer. With diagnosis of liver metastasis from gastric cancer, chemotherapy is recommended. However, to control the bleeding from gastric cancer, we performed distal gastrectomy and wedge resection of liver (S8). The histological examination of the liver tumor revealed to be a hepatic sclerosed hemangioma with hyalinized tissue and collagen fibers. We report herein a case of the rare tumor which was misdiagnosed as a liver metastasis of gastric cancer. (Keyword) 欧文論文 (Tokushima University Institutional Repository) ● Metadata: 106032 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.59.270 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23037199 ● Search Scopus @ Elsevier (PMID): 23037199 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.270 (Tokushima University Institutional Repository: 106032, DOI: 10.2152/jmi.59.270, PubMed: 23037199)
62.	池本哲也, Yuji Morine, Satoru Imura, Masahiko Fujii, 石橋広樹 and Mitsuo Shimada : 特集. 術後感染症を防ぐーDPC時代に向けてー術後感染症を防ぐためのわれわれの工夫肝臓手術, Surgical Therapy, Vol.92, No.4, 420-428, Apr. 2005. (Keyword) DPC / クリニカルパス / 感染防御 / 周術期管理 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520573330987132160 (CiNii: 1520573330987132160)
63.	Mitsuo Shimada, Masahiko Fujii, Yuji Morine, Satoru Imura, Tetsuya Ikemoto and Hiroki Ishibashi : Living-donor liver transplantation: present status and future perspective, The Journal of Medical Investigation : JMI, Vol.52, No.1 2, 22-32, Feb. 2005. (Summary) About 15 years have passed since the first liver transplant from a living donor (living donor liver transplantation: LDLT), and the status of the procedure has since been established as a standard cure for end-stage liver disease in Japan where liver transplantation (LTx) from deceased donors has not yet been accepted. However, the following problems are surfacing with the increase in the number of LDLTs between adults: graft size mismatching, an ABO blood-type incompatible transplantation, the expansion of LDLT indication to hepatocellular carcinoma (HCC), the relapse of hepatitis C after LDLT, marginal donors, and the freedom from immunosuppressive treatment. In this article we outline the present conditions of these problems and the future view of the LDLT. (Keyword) ABO Blood-Group System / Blood Grouping and Crossmatching / Carcinoma, Hepatocellular / Hepatitis C / History, 20th Century / History, 21st Century / Humans / Japan / Liver Neoplasms / Liver Transplantation / Living Donors / Tissue and Organ Procurement (Tokushima University Institutional Repository) ● Metadata: 110753 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.52.22 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15751270 ● Search Scopus @ Elsevier (PMID): 15751270 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.52.22 (Tokushima University Institutional Repository: 110753, DOI: 10.2152/jmi.52.22, PubMed: 15751270)
64.	Yuji Morine, Masahiko Fujii, Satoru Imura, Tetsuya Ikemoto and Mitsuo Shimada : 特集肝移植の最新の進歩と問題点選択，適応基準とIC取得，実践時期の設定肝細胞癌に対する肝移植, KAN TAN SUI, Vol.50, No.1, 75-84, Jan. 2005.
65.	Satoru Imura, 池本哲也, Yuji Morine, Masahiko Fujii, 石橋広樹 and Mitsuo Shimada : 特集. 肝切除術:成功の秘訣肝予備能検査:最新の知見, 消化器外科, Vol.28, 401-408, 2005.
66.	Mitsuo Shimada, Masahiko Fujii, Satoru Imura, Yuji Morine, 石橋広樹, 伊地知秀樹 and 八木博司 : 生体肝移植における過小グラフトに対する高圧酸素療法の有用性, 日本臨床高気圧酸素・潜水医学会雑誌, Vol.1, 46-50, 2005.
67.	Masahiko Fujii, Satoru Imura, Yuji Morine, 池本哲也, Yuji Soejima and Mitsuo Shimada : 剥離と切離実質臓器(肝胆膵), 消化器外科, Vol.28, 1369-1378, 2005.
68.	池本哲也, Yuji Morine, Satoru Imura, Yuji Soejima, Masahiko Fujii and Mitsuo Shimada : Present condition of liver transplantation and future problem. 3. Measure for rejection and infection., Acta Hepatologica Japonica, Vol.46, No.6, 310-316, 2005. (Keyword) 肝移植 / 拒絶反応 / 感染防御 (Link to Publication Site) ● Publication site (DOI): 10.2957/kanzo.46.310 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679766043776 ● Search Scopus @ Elsevier (DOI): 10.2957/kanzo.46.310 (DOI: 10.2957/kanzo.46.310, CiNii: 1390282679766043776)
69.	Masahiko Fujii, Satoru Imura, Yuji Morine, 池本哲也 and Mitsuo Shimada : 特集肝切除・部分肝移植後の肝再生と肝不全部分肝移植後の肝再生と肝不全—基礎と臨床—, 日本外科学会雑誌, Vol.105, 680-686, 2004.
70.	Yuji Morine, Masahiko Fujii, Satoru Imura, 池本哲也 and Mitsuo Shimada : 今日の問題生体肝移植の現状と将来展望, Surgical Therapy, Vol.91, 315-324, 2004.

Proceeding of International Conference:

1.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki and Mitsuo Shimada : Preoperative weight loss program for HCC patients with high body mass index in hepatectomy., APASL 2024 Kyoto(アジア太平洋肝臓学会), Kyoto, Mar. 2024.
2.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Yuhei Waki and Mitsuo Shimada : New onlocogical resectability of CRLM and multidisciplinary treatment strategy, APASL 2024 Kyoto(アジア太平洋肝臓学会), Kyoto, Mar. 2024.
3.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : Preoperative weight loss program for hepatocellular carcinoma patients with high body mass index in hepatectomy., ASCO-GI 2024, San Francisco, Jan. 2024.
4.	Mitsuo Shimada, Yuuma Wada, Takayuki Noma, Yu Saitou and Yuji Morine : The combination of CD8 and TIM3 expression to predict survival outcomes in hepatocellular carcinoma., ASCO-GI 2024, San Francisco, Jan. 2024.
5.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Shin-ichiro Yamada : Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma, IHPBA2020, Melbourne, Nov. 2020.
6.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou and Shin-ichiro Yamada : Treatment Strategy for Synchronous Liver Metastases from Colorectal Cancer, IHPBA2020, Melbourne, Nov. 2020.
7.	Kazunori Tokuda, Mitsuo Shimada, Tetsuya Ikemoto, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Satoru Imura and Yuji Morine : The investigation of optimal transplantation site of insulin producing cell differentiated from human adipose derived stem cell., ISCT2020, Paris, May 2020. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcyt.2020.03.194 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcyt.2020.03.194 (DOI: 10.1016/j.jcyt.2020.03.194)
8.	Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Shin-ichiro Yamada, Yusuke Arakawa, Satoru Imura, Yuji Morine and Mitsuo Shimada : Effective 3D culture of hepatocyte like cells from human adipose derived mesenchymal stem cells., ISCT2020, Paris, May 2020. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcyt.2020.03.178 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcyt.2020.03.178 (DOI: 10.1016/j.jcyt.2020.03.178)
9.	Tetsuya Ikemoto, Mitsuo Shimada, Kazunori Tokuda, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Satoru Imura and Yuji Morine : The generation of effective insulin-producing cells from ADSC derived from type 1 diabetes mellitus patients., ISCT2020, Paris, May 2020. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcyt.2020.03.147 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcyt.2020.03.147 (DOI: 10.1016/j.jcyt.2020.03.147)
10.	Mitsuo Shimada, Tetsuya Ikemoto, Kazunori Tokuda, Yu Saitou, Katsuki Miyazaki, Yusuke Arakawa, Satoru Imura and Yuji Morine : Long-term results of transplanted insulin producing cells differented from human adipose stem cells in mice., ISCT2020, Paris, May 2020. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jcyt.2020.03.186 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcyt.2020.03.186 (DOI: 10.1016/j.jcyt.2020.03.186)
11.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : Significance of frailty in prognosis after hepatectomy in older patients with hepatocellular carcinoma., ASCO-GI, San Francisco, Jan. 2020. (Link to Publication Site) ● Publication site (DOI): 10.1245/s10434-020-08742-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32562115 ● Search Scopus @ Elsevier (PMID): 32562115 ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-020-08742-w (DOI: 10.1245/s10434-020-08742-w, PubMed: 32562115)
12.	Yusuke Arakawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Katsuki Miyazaki : Evaluation of the ratio of plasma fibrinogen to platelet in resectable pancreatic cancer., ASCO-GI, San Francisco, Jan. 2020. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2020.38.4_suppl.756 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2020.38.4_suppl.756 (DOI: 10.1200/JCO.2020.38.4_suppl.756)
13.	Mitsuo Shimada, Hiroki Ishibashi, Yuji Morine, Kubota Masayuki and Fujii Hideki : Nationwide survey of pancreaticobiliary maljunction focusing on biliary cancer incidence in Japan., ASCO-GI, San Francisco, Jan. 2020. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2020.38.4_suppl.587 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2020.38.4_suppl.587 (DOI: 10.1200/JCO.2020.38.4_suppl.587)
14.	Masato Yoshikawa, Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou and Katsuki Miyazaki : Prognostic prediction of mass-forming intrahepatic cholangiocarcinoma from ADC value of DWI-MRI, IASGO2019, Bangkok, Oct. 2019.
15.	Katsuki Miyazaki, Tetsuya Ikemoto, Mitsuo Shimada, Feng Rui, Yu Saitou, Shuichi Iwahashi, Yuji Morine and Satoru Imura : THE IMPACT OF RED LED IRRADIATION ON DIFFERENTIATION FOR INSULIN-PRODUCING CELLS FROM MESENCHYMAL STEM CELL, ESOT2019, Copenhagen, Sep. 2019.
16.	Yu Saitou, Shogo Oota, Tetsuya Ikemoto, Shuichi Iwahashi, Yuji Morine, Satoru Imura, Shin-ichiro Yamada and Mitsuo Shimada : THE NEW ROLE OF ZINC ION IN INSULIN-PRODUCING CELLS DIFFERENTIATION FROM ADIPOSE DERIVED MESENCHYMAL STEM CELLS., ESOT2019, Copenhagen, Sep. 2019.
17.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Feng Rui, Shin-ichiro Yamada, Shuichi Iwahashi, Yuji Morine and Satoru Imura : THE POTNETIALLY CLINICAL APPLICATION OF XENO-ANTIGEN FREE DIFFERENTIATION PROTOCOL FOR INSULINPRODUCING CELLS USING HUMAN RECOMBINANT PEPTIDE PETALOID Μ-PIECE FROM ADIPOSE-TISSUE DERIVED MESENCHYMAL STEM CELL, ESOT2019, Copenhagen, Sep. 2019.
18.	Mitsuo Shimada, Tetsuya Ikemoto, Yuuma Wada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and Shogo Oota : Characteristic difference of adiposederived mesenchymal stem cells from subcutaneous and visceral fat tissue for generating insulin-producing cell, ESOT2019, Copenhagen, Sep. 2019.
19.	Toshiaki Yoshimoto, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Tomohiko Miyatani, Kouzou Yoshikawa, Yuji Morine and Mitsuo Shimada : The tumor suppressive effects of blue LED via Opn3 in colon cancer, 第10回日本・モンゴル国際消化器癌シンポジウム, ウランバートル, Aug. 2019.
20.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : Standardization of surgical technique in laparoscopic distal pancreatectomy, SAGES 2019, Baltimore, Apr. 2019.
21.	Shogo Oota, Shuichi Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : The feasibility of hepatectomy for the super-elderly patients with HCC., ASCO-GI, San Francisco, Jan. 2019. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.274 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.274 (DOI: 10.1200/JCO.2019.37.4_suppl.274)
22.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and 馮睿 : The effect of hepatic stellate cells on hepatocellular carcinoma progression., ASCO-GI, San Francisco, Jan. 2019. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.265 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.265 (DOI: 10.1200/JCO.2019.37.4_suppl.265)
23.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Validity of hepatic cone-unit resection for hepatocellular carcinoma., ASCO-GI, San Francisco, Jan. 2019. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.228 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.228 (DOI: 10.1200/JCO.2019.37.4_suppl.228)
24.	Mitsuo Shimada, Hiroki Teraoku, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu and Shin-ichiro Yamada : Role of central hypovascularity in the hepatic arterial phase of dynamic CT on mass-forming intrahepatic cholangiocarcinoma., ASCO-GI, San Francisco, Jan. 2019. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2019.37.4_suppl.205 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2019.37.4_suppl.205 (DOI: 10.1200/JCO.2019.37.4_suppl.205)
25.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : The approach for establishing safe, reliable and rapid pancreatoduodenectomy, 第9回日本・モンゴル国際消化器癌シンポジウム, Aug. 2018.
26.	Satoru Imura, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Outcome of left lobe living-donor liver transplantation in Tokushima, 27th International Congress of The Transplantation Society(TTS), Jun. 2018.
27.	Yu Saitou, Rui Feng, Chie Takasu, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Yuji Morine, Satoru Imura and Mitsuo Shimada : Establishment of effective differentiation protocols for insulin-producing cells using a new 3D culture system from adipose-tissue derived mesenchymal stem cell, 27th International Congress of The Transplantation Society(TTS), Jun. 2018.
28.	Mitsuo Shimada, Rui Feng, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Chie Takasu : Establishment of insulin producing cells differentiated from human adipose-derived mesenchymal stem cells using a 3D-culture system with xenoantigen free reagents, 27th International Congress of The Transplantation Society(TTS), Jun. 2018.
29.	Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto and Mitsuo Shimada : Significance of hypoxia inducible factor-1αexpression in colorectal liver metastasis., APASL STC2018, Yokohama, May 2018.
30.	Toshiaki Yoshimoto, Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku and Mitsuo Shimada : The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Sorafenib therapy combined with surgical resection or TACE, APASL STC2018, Yokohama, May 2018.
31.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : Reduced-port laparoscopic cholecystectomy for young surgeons, SAGES, Seattle, Apr. 2018.
32.	Satoru Imura, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Laparoscopic hemi-hepatectomy for liver tumor, SAGES, Seattle, Apr. 2018.
33.	Mitsuo Shimada, Shuichi Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Jun Higashijima : Usefulness of one-stop shop simulation for liver surgery using EOB-MRI., SAGES, Seattle, Apr. 2018.
34.	Masaaki Nishi, Mitsuo Shimada, Kono Toru, Yuji Morine, Kouzou Yoshikawa, Katsuno Hidetoshi, Maeda Koutarou, Koeda Keisuke, Morita Satoshi, Masahiko Watanabe, Kusano Mitsuo, Sakamoto Junichi, Saji Shigetoyo, Sokuoka HIroki, Ohtake Yuaya, Sato Yasuto, Kanematsu Takashi and Kitajima Masaki : Daikenchuto for Postoperative Bowel Dysfunction After Open Abdominal Surgery: A Pooled Analysis of Three Randomized Controlled Trials., SSO's 71st Annual Cancer Symposium, Chicago, Mar. 2018.
35.	Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku, Shogo Oota, Jun Higashijima and Mitsuo Shimada : Significance of hypoxia inducible factor-1 expression in liver metastasis of colorectal cancer., ASCO-GI, San Francisco, Jan. 2018.
36.	Yuji Morine, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Reduction of T-Box 15gene expression in tumor tissue as a prognostic biomarker for patients with heparocellular carcinoma., ASCO-GI, San Francisco, Jan. 2018.
37.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Masato Yoshikawa, Toshiaki Yoshimoto and Mitsuo Shimada : Preoperative Prognostic Nutritional Index Predicts Both Short-and Long-Term Outcomes after Liver Resection For Hepatocellular Carcinoma, AMERICAN COLLEGE OF SURGEONS 2017(ACS), San Diego, Oct. 2017.
38.	Tetsuya Ikemoto, Mitsuo Shimada, Shuichi Iwahashi, Rui Feng, Yu Saitou, Satoru Imura and Yuji Morine : The establishmenmt of effective differentiation protocols for insulin-producing cells using 3D culture system from rat adipose-tissue derived mesenchymal stem cell, 18th Congress of the European Society for Organ Transplantation(ESOT), Barcelona, Sep. 2017.
39.	Rui Feng, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Kouzou Yoshikawa, Toshiaki Yoshimoto and Jun Higashijima : The impact of red LED irradiation on hepatocytes preservation, 18th Congress of the European Society for Organ Transplantation(ESOT)2017, Barcelona, Aug. 2017.
40.	Mitsuo Shimada, Rui Feng, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Toshiaki Yoshimoto and Jun Higashijima : A new 2-step protocol for human adipose derived mesenchymal stem cell differentiation to insulin-producing cells using xeno-antigen free reagents, 18th Congress of the European Society for Organ Transplantation(ESOT), Barcelona, Aug. 2017.
41.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Shuichi Iwahashi, Masaaki Nishi, Jun Higashijima, Satoru Imura and Yuji Morine : Clinical impact of Tr1 and FOXP3+regulatory Tcell as precise immunological biomarkers for reflecting cancer status, 47th World Congress of Surgery(WCS), バーゼル, Aug. 2017.
42.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou and Masato Yoshikawa : Reduced-port laparoscopic cholecystectomy with 3mm minute-diameter forceps., SAGES, Houston, Mar. 2017.
43.	Satoru Imura, Atsushi Takata, Toshiaki Yoshimoto, Masato Yoshikawa, Hiroki Teraoku, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Comparative analysis of the outcome between open and laparoscopic partial liver resection for hepatocellular carcinoma., SAGES, Houston, Mar. 2017.
44.	Mitsuo Shimada, Shuichi Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Jun Higashijima : New technology of `One-stop shop' liver surgery simulation equipped with assessment of total and regional liver functional reserve., SAGES, Houston, Mar. 2017.
45.	Yu Saitou, Yuji Morine, Chie Takasu, Shuichi Iwahashi, Jun Higashijima, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Role of HSF1 expression for tumor microenvironment in intrahepatic cholangiocarcinoma., ASCO-GI, San Francisco, Jan. 2017. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2017.35.4_suppl.249 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2017.35.4_suppl.249 (DOI: 10.1200/JCO.2017.35.4_suppl.249)
46.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Hiroki Teraoku, Masato Yoshikawa and Jun Higashijima : Treatment strategy for colorectal liver metastases:Clinical impact of FOLFOXIRI regimen for unresectable cases., ASCO-GI, San Francisco, Jan. 2017. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2017.35.4_suppl.780 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2017.35.4_suppl.780 (DOI: 10.1200/JCO.2017.35.4_suppl.780)
47.	Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa, Hiroki Teraoku and Jun Higashijima : Characteristics of intrahepatic cholangiocarcinoma according to tumor location., ASCO-GI, San Francisco, Jan. 2017. (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2017.35.4_suppl.406 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2017.35.4_suppl.406 (DOI: 10.1200/JCO.2017.35.4_suppl.406)
48.	Masato Yoshikawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : Current status and effect of laparoscopic training for young surgeon, 40th World Congress of the International College of Surgeons (ICS 2016), Kyoto, Oct. 2016.
49.	Daichi Ishikawa, Tetsuya Ikemoto, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Chie Takasu, Yu Saitou, Shuichi Iwahashi, Yuji Morine, Satoru Imura and Mitsuo Shimada : Signigficance of CD4+CD49b+regulatory T cells and Foxp3+regulatory T cells in the peripheral blood of cancer patients, 40th World Congress of the International College of Surgeons (ICS 2016), Kyoto, Oct. 2016.
50.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : Recurrent feature after radiofrequency ablation therapy for hepatocellular carcinoma, 4th International Conference of FACO, 廈門, Sep. 2016.
51.	Hisami Okumura, Shoko Wada, Takafumi Katayama, Satoru Imura, Yuji Morine, Mitsuo Shimada and Eiji Takeda : Effect of hepatectomy on energy metabolism in patients with liver cancer and cholangiocalcinoma by the difference of resection volume, 38th European Congress for Nutrition and Metabolism, Copenhagen, Sep. 2016.
52.	Masato Yoshikawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Atsushi Takata and Toshiaki Yoshimoto : Elevated preoperative serum CEA levels in patients with HCC is associated with prognosis and EMT, 26th World Congress Of the IASGO 2016, Seoul, Sep. 2016.
53.	Masato Yoshikawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : Elevated preoperative serum CEA levels in patients with HCC is associated with prognosis and EMT, 第8回日本・モンゴル消化器癌国際シンポジウム, ウランバートル, Aug. 2016.
54.	Satoru Imura, Masato Yoshikawa, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Our strategy for antibody mediated rejection in living donor liver transplantation, 第8回日本・モンゴル消化器癌国際シンポジウム, ウランバートル, Aug. 2016.
55.	Atsushi Takata, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Kouzou Yoshikawa and Toshiaki Yoshimoto : The correlation between serum CA19-9 level and the epigenetic alteration in intrahepatic cholangiocarcinoma., IASGO Advanced Post-Graduate Course in Sendai 2016, Sendai, Apr. 2016.
56.	Yu Saitou, Atsushi Takata, Hiroki Teraoku, Masato Yoshikawa, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : The effect od HDACi in ADSC differentiation in to insulin producing cells., Transplantation Science Symposium (TSS) Asian Regional Meeting 2016, Tokyo, Apr. 2016.
57.	Satoru Imura, Takuya Tokunaga, Masayuki Sumitomo, Shin-ichiro Yamada, Chie Takasu, Yu Saitou, Jun Higashijima, Kouzou Yoshikawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Usefulness of telementoring system to develop laparoscopic surgery in rural hospital, Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
58.	Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yamada Shinichiro, Teraoku Hiroki, Yoshikawa Masato and Chie Takasu : Effective stepwise training and procedure-standardization for young surgeons to perform laparoscopic left hepatectomy., Society American Gastrointestinal Endoscopic Surgeons (SAGES 2016), Boston, Mar. 2016.
59.	Yoshikawa Masato, Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Yamada Shinichiro, Yoshimoto Toshiaki and Takata Atsushi : Elevated preoperative serum CEA levels in patients with HCC is associated with prognosis and EMT., The Asian Pacific Association for the Study of the Liver, Tokyo, Feb. 2016.
60.	Shinichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Teraoku Hiroki, Yoshikawa Masato, Yoshimoto Toshiaki and Takata Atsushi : High NEK2 expression in hepatocellular carcinoma patients after hepatectomy, The Asian Pacific Association for the Study of the Liver, Tokyo, Feb. 2016.
61.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Hiroki Teraoku : Treatment strategy for intrahepatic cholangiocarcinoma: From optimal surgical management to adjuvant therapy., 2016 Gastrointestinal Cancers Symposium, San Francisco, Jan. 2016.
62.	Yuji Morine : Treatment strategy for intrahepatic cholangiocarcinoma: From optimal surgical management to adjuvant therapy., San Francisco, Jan. 2016.
63.	Teraoku Hiroki, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, Yu Saitou and Chie Takasu : The expression of KI-67 is a useful prognostic factor in patients with colorectal liver metastasis., 46th World Congress of Surgery (WCS)2015, Aug. 2015.
64.	Mitsuo Shimada, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Jun Higashijima and Chie Takasu : Folfoxiri regimen brings early ``conversion'' and better long-term outcome in patients with initially unresectable colorectal liver metastases, 46th World Congress of Surgery (WCS)2015, Aug. 2015.
65.	Teraoku Hiroki, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Daichi Ishikawa and Yoshikawa Masato : The expression of Ki-67 is a useful prognostic factor in patients with colorectal liver metastasis, IASGO 2015 post graduate course, Tokyo, Jun. 2015.
66.	良元俊昭, GY Wubetu, Shin-ichiro Yamada, 石川大地, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Impact of STAT4 expression on cellular immunity and prognosis in hepatocellular carcinoma., ASCO-GI 2015 Gastrointestinal Cancers Symposium, Jan. 2015.
67.	Shuichi Iwahashi, Yismaw Gizachew, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, 吉川雅登, 寺奥大貴 and Mitsuo Shimada : The antitumor effect of epigallocatechin-3-gallate on gastroenterological cancer., ASCO-GI 2015 Gastrointestinal Cancers Symposium, Jan. 2015.
68.	Satoru Imura, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Hiroshi Shibata and Hidenori Miyake : Long-term survivors after sorafenib therapy in unresectable hepatocellular carcinoma., ASCO-GI 2015 Gastrointestinal Cancers Symposium, Jan. 2015.
69.	Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登, Jun Higashijima and Chie Takasu : Impact of FOLFOXIRI regimen on early ``Conversion'' and long-term outcome in patients with initially unresectable colorectal liver metastases, ASCO-GI 2015 Gastrointestinal Cancers Symposium, Jan. 2015.
70.	Hisami Okumura, K Sugihara, M Yamamoto, Yutaka Taketani, Tetsuya Ikemoto, Yusuke Arakawa, Satoru Imura, Yuji Morine, Satoru Imura, Mitsuo Shimada and Eiji Takeda : Recovery of non-protein respiratory quotient and health related quality of life after living-donor liver transplantation, 36th European Congress for Nutrition and Metabolism, Sep. 2014.
71.	Hisami Okumura, Kohei Sugihara, Momo Yamamoto, Yutaka Taketani, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Mitsuo Shimada and Eiji Takeda : Recovery of non-protein respiratory quotient and health related quality of life after living-donor liver transplantation., 36th European Congress for Nutrition and Metabolism, Geneva, Switzerland 2014, September 6-9, Sep. 2014.
72.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Shuichi Iwahashi : Useless of 3D-virtual hepatectomy and intraoperative navigation system in liver resection, 第28回国際コンピュータ支援放射線医学・外科学会議(CARS), Fukuoka, Jun. 2014. (Keyword) 国際学会
73.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Yu Saitou : Effects of valporic acid as a histone deacetylase inhibitor in combination with S-1 on advanced pancreatobiliary tract cancers:Clinical study phases and ., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014.
74.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi and Yu Saitou : Clinical impact of reflection to expression of EMT marker in intraductal papillary mucinous neoplasm., Gastrointestial Cancers Symposium(ASCO-GI), Jan. 2014. (Keyword) 国際学会
75.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, D Ishikawa, Chie Mikami, Z Chengzhan, A Tajima and I Imoto : Identification of aberrant DNA methylation profiles in non-tumor liver tissues of patients with non-B, non-C hepatocellular carcinoma., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014. (Keyword) 国際学会
76.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Yu Saitou : Effects of valproic acid as a histone deacetylase inhibitor in combination with S-1 on advanced pancreatobiliary tract cancers: Clinical study phases I and II., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014.
77.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi and Yu Saitou : Clinical impact of reflection to expression of EMT marker in intraductal papillary mucinous neoplasm., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014.
78.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Chie Takasu, Chengzhan Zhu, Tajima A and Imoto I : Identification of aberrant DNA methylation profiles in non-tumor liver tissues of patients with non-B, non-C hepatocellular carcinoma., Gastrointestinal Cancers Symposium(ASCO-GI), San Francisco, Jan. 2014.
79.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Chie Takasu : Potential Predictive Factors for Microscopic Portal Invasion in Hepatocellular Carcinoma wwithout Macroscopic Vascular Invasion., American College of Surgeons 2013(ACS), Washington, D.C., Oct. 2013.
80.	Zhu Chengzhan, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地, A Tajima, I Imoto and Mitsuo Shimada : Hypomethylation of LINE-1 is associated with a poor prognosis after hepatectomy for patients with hepatocellular carcinoma., 1st International Conference of Federation of Asian Clinical Oncology(FACO), 中国, Sep. 2013.
81.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地, Zhu Chengzhan, A Tajima and I. Imoto : Genome-wide analysis of aberrant DNA methylation profiling in non-tumor liver tissues of patients with non-B non-C hepatocellular carcinoma, 1st International Conference of Federation of Asian Clinical Oncology(FACO), 中国, Sep. 2013.
82.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 石川大地 and Bat-Erdene Batsaikhan : Prediction of Recurrence of Hepatocellular Carcinoma after Curative Hepatectomy Using Preoperative lens Culinaris Agglutinin-Reactive Fraction of Alpha-Fetoprotein(AFP-L3)., 第5回日本・モンゴル消化器がんシンポジウム, モンゴル, Sep. 2013.
83.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地 and Bat-Erdene Batsaikhan : Recent Advancements in Liver Surgery : Assessment of Functional Reserve, Simulation, and Navigation., 第5回日本・モンゴル消化器がんシンポジウム, モンゴル, Sep. 2013.
84.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi and 山田眞一郎 : Ompact of Expression of Twist1 and Bmi1 in Intraductal Papillary Mucinous Neoplasm., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
85.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Chie Takasu : Significance of Stem Cell Markers Expression in Cholangiolocellular Carcinoma., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
86.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : Impact of Bioelectrical Impedance Analysis in Pancreato-Duodenectomy., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
87.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : Impact of Bioelectrical Impedance Analysis in Pancreato-Duodenectomy., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
88.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎 and 石川大地 : Strategy for Intrahepatic Cholangiocarcinoma: From Cancer Stem Cell to Multidisciplinary., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
89.	Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu and 山田眞一郎 : Recent Advancements in Liver Surgery: Assessment of Funcional Reserve, Simulation and Navigation., International Association of Surgeons, Gastroenterologists and Oncologists 2013(IASGO), ルーマニア, Sep. 2013.
90.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya, Horohiko Sato and Hidenori Miyake : The gene profile in the spleen under rat small-for-size graft model using cDNA microarray and pathway analaysis., The 13th Congress of the Asian Society Of Transplantation 2013(CAST), Kyoto, Sep. 2013.
91.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and Yu Saitou : Successfully treated case of liver transplant recipient with donor-specific antibody against human leukocyte antigen., The 13th Congress of the Asian Society Of Transplantation 2013(CAST), Kyoto, Sep. 2013.
92.	Hiroki Mori, Hiroki Ishibashi, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, 矢田圭吾 and Mitsuo Shimada : Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation, International Surgical Week 2013(ISW), ヘルシンキ, Aug. 2013.
93.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa and Mami Kanamoto : ABO incompatible living donor liver transplantation for HCV positive recipients., International Surgical Week 2013(ISW), ヘルシンキ, Aug. 2013.
94.	Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Shuichi Iwahashi : Successful management of liver transplant recipient with strongly positive donor-specific antibody against human leukocyte antigen., International Surgical Week 2013(ISW), ヘルシンキ, Aug. 2013.
95.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, 山田眞一郎 and Hidenori Miyake : Laparoscopic hepatic resection for metastatic liver tumor of colorectal cancer: comparative analysis of short and long term results., Society of American Gastrointestinal and Endoscopic Surgeons 2013(SAGES), Baltimore, Apr. 2013.
96.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁 and 石川大地 : Laparoscopic surgery using vessel sealing systmen for giant liver cysts., Society of American Gastrointestinal and Endoscopic Surgeons 2013(SAGES), Baltimore, Apr. 2013.
97.	Mitsuo Shimada, Shuichi Iwahashi, 山田眞一郎, Yu Saitou, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : Laparoscopic hepatectomy could be the first choice of treatment in selected patients with hepatocellular., Society of American Gastrointestinal and Endoscopic Surgeons 2013(SAGES), Baltimore, Apr. 2013.
98.	Mitsuo Shimada, Yuji Morine, Hiroki Ishibashi, H Takamatsu and H Shimada : Characteristics of Biliary Tract Cancer in Patients with Pancreaticobiliary Maljunction : The Report of Japan-Nationwide Survey., The 2nd JSGE International Topic Conference, Mar. 2013. (Keyword) 国内学会
99.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎 and Hidenori Miyake : Treatment Strategy for Advanced Biliary Circinomas:Repeat Resection of Biliary Cancers., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Paris, Dec. 2012. (Keyword) 国際学会
100.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地, Horohiko Sato and Hidenori Miyake : Treatment strategy based on the characteristics of non-tumor liver tissues in patients., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Paris, Dec. 2012. (Keyword) 国際学会
101.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Horohiko Sato and Hidenori Miyake : Impact of dendritic cell-induced regulatory T cell as a possible novel biomarker for surgical indication of IPMN., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Paris, Dec. 2012. (Keyword) 国際学会
102.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and 石川大地 : Recent Advancement of Surgical Treatment Of Liver Cancer., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Paris, Dec. 2012. (Keyword) 国際学会
103.	Mitsuo Shimada, Toru Utsunomiya, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Hidenori Miyake : A New Anatomical Resection of the Liver Based on hybrid Concept of Portal Perfusion of Anterior Segment and Venous Drainage of Superior Right Hepatic Vein., 22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2012), Paris, Dec. 2012. (Keyword) 国際学会
104.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 杉本光司, 齋藤裕 and 山田眞一郎 : Molecular Characteristics of Non-Tumor Liver Tissues May Help to Determine Therapeutic Strategy in Patients with Hepatocellular Carcinoma., American College Of Surgeons Annual Crinical Congress(ACS2012), Sep. 2012. (Keyword) 国際学会
105.	Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Tomohiko Miyatani, 齋藤裕, 山田眞一郎 and Enkhbold Chinbold : One-Stop Shopping for 3-Dimensional Anatomy of Hepatic Vasculature and Bile Duct with a Special Reference to Biliary Image Reconstruction., American College Of Surgeons Annual Crinical Congress(ACS2012), Chicago, Sep. 2012. (Keyword) 国際学会
106.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Nobuhiro Kurita, Horohiko Sato, Yuji Morine, Tetsuya Ikemoto, Tomohiko Miyatani, 柏原秀也 and 淺野間理仁 : Simultaneous laparoscopic resection of primary colorectal cancer and metastatic liver tumor., 4th Japanese-Mongolian International Cancer Joint Symposium, ウランバートル, Sep. 2012. (Keyword) 国際学会
107.	松本規子, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka and Hidenori Miyake : Role of CD151 expression in gallbladder carcinoma., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
108.	Tomohiko Miyatani, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori and Jun Hanaoka : Chemotherapeutic regimen to reduce the liver damage by oxaliplatin-based chemotherapy and to enhance conversion in patients with initially unresectable colorectal liver metastases., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
109.	寺奥大貴, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto and Hidenori Miyake : Active resection for heterochronial triple cholangiocellar carcinomas., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
110.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Hidenori Miyake : Impact of TJ-137 administration for the prevention of asverse events during chemotherapy in patients with advanced pancreatic cancer patients., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
111.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori and Hidenori Miyake : Usefulness of evaluating functional of the liver using EOB-MRI and indocyanin green fluorescence navigation during operation for safe and curative hepatectomy., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
112.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Jun Hanaoka, Tomohiko Miyatani and Mami Kanamoto : Impact of human adipose tissue derived regenerative cell for cryopreserved porcine islets., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
113.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕 and Hidenori Miyake : Treatment strategy for advanced biliary carcinomas: Aspecial reference to adjuvant chemotherapy and repeated hepatectomy for intrahepatic recurrence., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
114.	Mitsuo Shimada, Toru Utsunomiya, Mami Kanamoto, Tomohiko Miyatani, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Hidenori Miyake : A new hepatectomy based on a hybrid concept of portal perfusion of anterior segment and venous drainage area of suoerior right hepatic vein., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
115.	Hiroki Mori, Hiroki Ishibashi, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hidenori Miyake and Mitsuo Shimada : Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maliunction through both epigenetic and genetic pathway., 10th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2012), Paris, Jul. 2012. (Keyword) 国際学会
116.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, Tomohiko Miyatani, 齋藤裕, 山田眞一郎 and 淺野間理仁 : Indoleamine 2, 3-dioxygenase (IDO) and jagged 1 expression on dendrtic cells reflect peripheral regulatory T cells in pancreatic neoplasms., Digestive Disease Week (DDW2012), San Diego, May 2012. (Keyword) 国際学会
117.	Hiroki Mori, Hiroki Ishibashi, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, 淺野間理仁, 山田眞一郎, Hidenori Miyake and Mitsuo Shimada : Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction., Digestive Disease Week (DDW2012), San Diego, May 2012. (Keyword) 国際学会
118.	Toru Utsunomiya, Mitsuo Shimada, Jun Hanaoka, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve., Journal of Gastroenterology, Vol.47, No.4, 470-476, Apr. 2012. (Summary) Preoperative estimation of the liver functional reserve is important in liver surgery. We evaluated the role of dynamic magnetic resonance (MR) imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), i.e., EOB-MRI, for determining liver functional reserve. Fifty patients who underwent EOB-MRI to examine their liver tumors were included in this study. We first performed a pixel-by-pixel comparison of registered MR images and activity images with Tc-99m galactosyl human serum albumin (GSA) on each slice, and the correlation coefficient was calculated for 8 patients. We also determined the correlation coefficient between the relative signal intensity (SI) values of EOB-MRI and preoperative liver function, such as the GSA, indocyanine green dye retention at 15 min (ICGR15), and prothrombin time. The mean of the correlation coefficients for 512 × 512 matrices between the EOB-MRI and the GSA was 0.83 ± 0.05 (ranging from 0.73 to 0.87). The correlation coefficient between the relative SI of the EOB-MRI and the receptor index (LHL15) of GSA was 0.56 (P < 0.01). Better correlation coefficients were observed between the relative SI and the liver function test, including ICGR15 (r = -0.67, P < 0.01) and prothrombin time (r = 0.59, P < 0.01). In a patient with hilar cholangiocarcinoma whose right hepatic duct was obstructed, the relative SI in the right lobe (2.4 ± 0.3) was significantly lower than that in the left lobe (3.1 ± 0.1). EOB-MRI represents a practical and reliable imaging technique that may be used to estimate regional liver functional reserve in the clinical setting. (Keyword) Adult / Aged / Aged, 80 and over / Contrast Media / Female / Gadolinium DTPA / Humans / Liver / Liver Function Tests / Magnetic Resonance Imaging / Male / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-011-0513-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22170416 ● Summary page in Scopus @ Elsevier: 2-s2.0-84863084638 (DOI: 10.1007/s00535-011-0513-8, PubMed: 22170416, Elsevier: Scopus)
119.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, 齋藤裕, 浅野間理仁 and 山田眞一郎 : Specific miRNA expression profiles of non-tumor liver tissues predict the risk for multicentric occurrence of hepatocellular carcinoma., American Association for Cancer Research (AACR2012), Chicago, Mar. 2012.
120.	吉川雅登, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto and Hidenori Miyake : Laparoscope-assisted hepatic resection for gallbladder cancer., Society of American Gastrointestinal Endoscopic Surgeons (SAGES2012), San Diego, Mar. 2012.
121.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司 and Hidenori Miyake : Laparoscopic hepatic resection for hepatocellular carcinoma: comparative analysis of short and long term results., Society of American Gastrointestinal Endoscopic Surgeons (SAGES2012), San Diego, Mar. 2012.
122.	Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka and Hidenori Miyake : Feasibility of laparoscopic hepatectomy for intrahepatic cholangiocarcinoma., Society of American Gastrointestinal Endoscopic Surgeons (SAGES2012), San Diego, Mar. 2012.
123.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 浅野間理仁 : Action of SDF-1/CXCR4 axis in liver metastasis of colorectal cancer., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
124.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Usefulness of gemcitabine combined with 5-fluorouracil and cisplatin (GFP) for patients with advanced biliary carcinoma as a postoperative adjuvant chemotherapy., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
125.	Mitsuo Shimada, Toru Utsunomiya, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Tomohiko Miyatani, Horohiko Sato and Nobuhiro Kurita : Effect of bevacizmab on sinusoidal injury in patients receiving oxaliplatin-based chemotherapy and liver damage after massive hepatectomy in rats., Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2012), San Francisco, Jan. 2012.
126.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, 山田眞一郎 and 浅野間理仁 : Beneficial effects of adiose-derived stem cells on severe hepatic damage due to hepatectomy and ischemia reperfusion injury in mice., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
127.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Bevacizumab ameliorates sinusoidal injury after oxaliplatin-based chemotherapy and enhances liver regeneration after hepatectomy., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
128.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : Application of EOB-MRI as the preoperative simulation for liver surgery: simultaneous evaluation of liver function and volume., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
129.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011. (Link to Publication Site) ● Publication site (DOI): 10.1007/s00535-009-0164-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19997856 ● Summary page in Scopus @ Elsevier: 2-s2.0-77949265477 (DOI: 10.1007/s00535-009-0164-1, PubMed: 19997856, Elsevier: Scopus)
130.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : Effects of gemcitabine combined with 5-fluorouracil and cisplatin (GFP) for patients with unresectable biliary carcinoma and its possible usefulness for postoperative adjuvant chemotherapy., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
131.	Mitsuo Shimada, Jun Hanaoka, Tomohiko Miyatani, Mami Kanamoto, Hiroki Mori, Satoru Imura, Yuji Morine and Toru Utsunomiya : Impact of FOLFOXIRI plus bevacizumab on conversion'' in patients with initially unresectable from colorectal cancer''., 21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologigts(IASGO2011), Tokyo, Nov. 2011.
132.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : CD44 Expression Can Predict Prognosis of Intrahepatic Cholangiocarcinoma., 97th Clinical Congress of American college of Srgeons (ACS), San Francisco, Oct. 2011.
133.	Mitsuo Shimada, Yuji Morine, Hiroki Mori, Takamatsu Hideo and Shimada Hiroshi : Characteristics of Biliary Tract Cancer in Patients with Pancreaticobiliary Maljunction: Second Report of Japan-Nationwide Survey., 97th Clinical Congress of American college of Srgeons (ACS), San Francisco, Oct. 2011.
134.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕 and 浅野間理仁 : Cytoprotective effect of human adipose tissue derived stem cell on porcine islet cells., 12th Congress of the Asian Society of Transplantation (CAST2011), Seoul, Sep. 2011.
135.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, 山田眞一郎, Yuji Morine, Satoru Imura, Hiroki Mori, Jun Hanaoka, 杉本光司 and 浅野間理仁 : The possibility of adipose-derived stem cells for an alternative therapy for liver failure., 12th Congress of the Asian Society of Transplantation (CAST2011), Seoul, Sep. 2011.
136.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, 岩橋衆一 and 松本慎一 : The role of donor specific regulatory T cells expanded by interferon-gamma inducible indoleamine 2,3-dioxygenase(IDO)+ plasmacytoid dendritic cell., 12th Congress of the Asian Society of Transplantation (CAST2011), Seoul, Sep. 2011.
137.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Impact of left lobe graft on adult living donor liver transplantation : small-for-size graft is not a risk factor for short and long outcome., 12th Congress of the Asian Society of Transplantation (CAST2011), Seoul, Sep. 2011.
138.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, 山田眞一郎 and 浅野間理仁 : Ischemia reperfusion injury enhances SDF1 expressions and hhoming of adipose derived regenerative cells in the liver., 8th International Smposium on Minimal Residual Cancer (ISMRC2011), Osaka, Sep. 2011.
139.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Peripheral regulatory Tcell induced by Indoleamine 2,3-dioxygenase as a precise biomarker of pancreatic neoplasms., 8th International Smposium on Minimal Residual Cancer (ISMRC2011), Osaka, Sep. 2011.
140.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Role of histone deacetylase expression in IHCC: A possible epigenetic regulation of cancer stem cell., 8th International Smposium on Minimal Residual Cancer (ISMRC2011), Osaka, Sep. 2011.
141.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 浅野間理仁, Kume Hisae and Sasaki Hajime : Whey protein isolate,MEIN®, can reduce liver damege early after living donor liver transplantation., European Society for Organ Transplantation, glasgow, Sep. 2011.
142.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕 and 山田眞一郎 : Cytoprotective effect of human adipose tissue derived regenerative cell on porcine islet cells., European Society for Organ Transplantation, Sep. 2011.
143.	Hiroki Mori, Mitsuo Shimada, 齋藤裕, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 浅野間理仁 and 山田眞一郎 : The possibility of adipose-derived regenerative cells for an alternative therapy for liver failure., European Society for Organ Transplantation, glasgow, Sep. 2011.
144.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 浅野間理仁 and 山田眞一郎 : Chance of salvage transplantation after primary hepatectomy for hepatocellular carcinoma: a special reference to up-to-7 criteria., European Society for Organ Transplantation, glasgow, Sep. 2011.
145.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 浅野間理仁 and 山田眞一郎 : Impact of left lobe graft on adult living donor liver transplantation: small-for-size graft is not a risk factor for short and long outcome., European Society for Organ Transplantation, glasgow, Sep. 2011.
146.	杉本光司, 松本慎一, Tetsuya Ikemoto, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Mitsuo Shimada : The immunological tolerance effects of donor specific regulatory T cells through interferon-gamma inducible indoleamine 2,3-dioxygenase(IDO)+plasmacytoid dendritic cell., European Society for Organ Transplantation, Glasgow, Sep. 2011.
147.	Mitsuo Shimada, Satoru Imura, Hiroki Mori, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Toru Utsunomiya : Regeneration of caudate lobe in extended left lobe graft including caudate lobe after living donor liver transplantation., European Society for Organ Transplantation, glasgow, Sep. 2011.
148.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Hidenori Miyake : Comparison of short-term outcome and surgical stress response to laparoscopic and open hemihepatectomy., International Surgical Week, Yokohama, Aug. 2011.
149.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Mami Kanamoto : Green Tea Catechins Improve Liver Dysfunction Following Massive Hepatectomy Through Anti-Oxidative and Anti-Inflammatory Activities in Rat., Digestive Disease Week, Chicago, May 2011.
150.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, Mami Kanamoto, 岩橋衆一, 齋藤裕 and 浅野間理仁 : Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell line., 102nd American Association for Cancer Research (AACR2011), Orlando, Apr. 2011.
151.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎, 浅野間理仁 and Mami Kanamoto : Role of histone deacetylase expression in intrahepatic cholangiocarcinoma., 102nd American Association for Cancer Research, Orlando, Apr. 2011.
152.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Shuichi Iwahashi and Yu Saito : Utility of hybrid sils with minute diameter forceps in cholecystectomy, Society of American Gastrointestinal Endoscopic Surgeons (SAGES2011), テキサス, Mar. 2011.
153.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Shuichi Iwahashi, Yu Saito, Nobuhiro Kurita and Hidenori Miyake : Minimal Invasiveness of laparoscopic left hepatic lobectomy : A special referece to systemic inflammatory response syndrome, Society of American Gastrointestinal Endoscopic Surgeons (SAGES2011), テキサス, Mar. 2011.
154.	Nobuhiro Kurita, Mitsuo Shimada, Takashi Iwata, Masanori Nishioka, Yuji Morine, Kouzou Yoshikawa, Tomohiko Miyatani, Chie Mikami and Hideya Kashihara : Role of thrombospondin 1(THBS1) expression in peritoneal metastasis of gastric cancer treated with taxanes, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
155.	Yu Saito, Mitsuo Shimada, Yuji Morine, Shuichi Iwahashi, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori and Jun Hanaoka : Role of histone deacetylase expression on regulating cancer stem cells in intrahepatic cholangiocarcinoma, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
156.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Yu Saito : Effect of a histone deacetylase inhibitor on antitumor effect of gemcitabine to focus the gene network of ingenuity pathways analysis, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
157.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Shuichi Iwahashi, Yu Saito and Shinichiro Yamada : The impact of bevacizumab on liver regeneration following hepatectomy in rats, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
158.	Mitsuo Shimada, Masanori Nishioka, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : Impact of FOLFOXIRI plus bevacizumab on resectability and survival in patients with initially unresectable liver metastases from colorectal cancer, Gastrointestinal Cancers Symposium:Science and Multidiscriplinary Management of GI Malignancies (ASCO-GI 2011), San Francisco, Jan. 2011.
159.	Michihito Asanoma, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, Yu Saito and Shinichiro Yamada : Role of regulatory T cell and IDO as a biomarker for pancreatic IPMN, 20th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO), エジプト, Oct. 2010.
160.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Yu Saito and Michihito Asanoma : Histone deacetylase inhibitor enhances anti-tumor effect of gemcitabine on pancreatic cancer and cholangiocarcinoma cell line, 20th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO), エジプト, Oct. 2010.
161.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, Yu Saito, Michihito Asanoma and Shinichiro Yamada : Role of human adipose tissue-derived stem cells in gastroenterological disorders, 20th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO), エジプト, Oct. 2010.
162.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Yu Saito : Systematic anatomical hepatic repatic resection under preceding US-guided glissonean control by thermal ablation, アジアハイパーサーミア腫瘍学会第5回大会・日本ハイパーサーミア学会第27回大会合同大会, Fukuoka, Sep. 2010.
163.	Yu Saito, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Shuichi Iwahashi : The correlation between cancer stem like cells and epigenetic alteration in intrahepatic cholangiocarcinoma, The 9th International Conference of The Asian Clinical Oncology Society(ACOS2010), Gifu, Aug. 2010.
164.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi, Yu Saito and Shinichiro Yamada : Indolamine 2,3-deoxygenase (IDO) has influences for the aggressiveness of IPMN through Foxp3+CD4+CD25+Tcell (Treg) in peripheral blood, The 9th International Conference of The Asian Clinical Oncology Society(ACOS2010), Gifu, Aug. 2010.
165.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi and Yu Saito : Laparoscopic left liver resection: Technical refinement for standardization of laparoscopic left hepatic lobectomy, The 9th International Conference of The Asian Clinical Oncology Society(ACOS2010), Gifu, Aug. 2010.
166.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi and Yu Saito : Timing of salvage transplantation after primary hepatectomy for hepatocellular carcinoma: a special reference to recurrence pattern and Up-to-7 criteria, The 9th International Conference of The Asian Clinical Oncology Society(ACOS2010), Gifu, Aug. 2010.
167.	Kuyama Hisako, Hiroo Takehara, Akira Nii, Yuji Morine and Mitsuo Shimada : A case of infantile hemangioendothelioma with thrombocytopenia treated hepatectomy in emergency, 43th Annual Meeting of Pacific Association of Pediatric Surgeons.(PAPS), Kobe, May 2010.
168.	Shinichiro Yamada, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, Shuichi Iwahashi, Yu Saito, Yuko Kawata and Hidenori Miyake : Effect Rikkunshito, a kampo medicine, for gastro-intestinal sympotoms after pylorus-preserving pancreto-duodenectomy (PpPD), 9th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2010), ブエノスアイレス, Apr. 2010.
169.	Tetsuya Ikemoto, Mitsuo Shimada, Masato Komatu, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Yu Saito and Yuko Kawata : Effect of humen adipose-tissue derived-mesenchymas stem cell on streptozotocin-induced diabetic nude mice, 9th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2010), ブエノスアイレス, Apr. 2010.
170.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Shuichi Iwahashi, Yu Saitou, Nobuhiro Kurita and Hidenori Miyake : Laparoscopic resection of the left liver Technical refinements for standardization-, Society of American Gastrointestinal Endoscopic Surgeons (SAGES2010), Washington, D.C., Apr. 2010.
171.	Masahiko Fujii, Satoru Imura, Yuji Morine, H Shinohara and Mitsuo Shimada : Central Bisegmentectomy of the Liver with Pylorus-preserving Pancreatoduodenectomy for Advanced Cancer of the Gallbladder, 19th World Congress of International Society Digestive Surgery, Yokohama, Dec. 2004.

Proceeding of Domestic Conference:

1.	Yu Saitou, Tetsuya Ikemoto, Yuhei Waki, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞から分化誘導した肝細胞様細胞の免疫原性獲得に関する研究, 第23回日本再生医療学会総会, Mar. 2024.
2.	Takuya Tokunaga, Yuhei Waki, Hiroki Ishibashi, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : ADSCから分化したSchwann cell-like cellが神経修復へ与える影響に関する基礎的検討, 第23回日本再生医療学会総会, Mar. 2024.
3.	Yuhei Waki, Yu Saitou, Tetsuya Ikemoto, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞から分化誘導した肝細胞様細胞の尿素サイクル異常症モデルマウスへの移植効果, 第23回日本再生医療学会総会, Mar. 2024.
4.	Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 再生医療を用いた新たな膵β細胞(insulin producing cell:IPC)移植戦略の樹立に関する研究, 第23回日本再生医療学会総会, Mar. 2024.
5.	Hiroki Teraoku, Yuhei Waki, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 腫瘍関連マクロファージ(TAM)とのcrosstalkを介したLenvatinib耐性肝細胞癌における悪性度獲得機序, 第56回制癌剤適応研究会, Feb. 2024.
6.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki and Mitsuo Shimada : Atezolizmab+Bevacizumab療法ならびにTremelimumab+Durvalumab療法により縮小が得られ肝切除を施行し得たVp4を伴う進行肝細胞癌の一例, 第29回日本肝がん分子標的治療研究会, Jan. 2024.
7.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki and Mitsuo Shimada : 切除可能境界膵癌における集学的治療の意義, 第120回日本消化器病学会四国支部例会, Dec. 2023.
8.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 腹腔鏡下肝切除におけるPitfall -心房細動アブレーション後医原性心房中隔欠損を介した奇異性塞栓症-, 第36回日本内視鏡外科学会総会, Dec. 2023.
9.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 最大腫瘍径×個数を用いた新たなresectabilityと治療戦略の提唱, 第45回日本肝臓学会西部会, Dec. 2023.
10.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 肝内胆管癌における新たな予後予測 - MRI拡散強調画像と腫瘍浸潤リンパ球 –, 第45回日本肝臓学会西部会, Dec. 2023.
11.	Yuji Morine, Yu Saitou and Mitsuo Shimada : 進行肝細胞癌における至適肝切除適応の再考とconversion surgeryの意義, 第45回日本肝臓学会西部会, Dec. 2023.
12.	Yuuma Wada, Chie Takasu, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Hiroki Teraoku, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : 肝細胞癌におけるエクソソームmiRNAを介したLenvatinib耐性機序の検討, 第34回日本消化器癌発生学会総会, Nov. 2023.
13.	Yuhei Waki, Yuji Morine, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto and Mitsuo Shimada : 肝細胞癌微小環境におけるNrf2シグナルを介した癌細胞とTAMの相互作用, 第34回日本消化器癌発生学会総会, Nov. 2023.
14.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku and Mitsuo Shimada : 大建中湯(TU-100)のNASH発癌抑制効果に関する検討, 第34回日本消化器癌発生学会総会, Nov. 2023.
15.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Takayuki Noma and Mitsuo Shimada : 80歳以上の高齢者膵癌に対する膵頭十二指腸切除の治療成績, 第85回日本臨床外科学会総会, Nov. 2023.
16.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku and Mitsuo Shimada : 大腸癌多発肝転移における最大腫瘍径×個数を用いた肝切除基準と集学的治療方針の提唱, 第85回日本臨床外科学会総会, Nov. 2023.
17.	Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : EOB予備能評価に基づいた至適肝切除, JDDW 2023, Nov. 2023.
18.	Yuji Morine, Yu Saitou and Mitsuo Shimada : 脈管侵襲陽性肝細胞癌の至適治療法は肝切除です, JDDW 2023, Nov. 2023.
19.	Yuhei Waki, Yuji Morine, Takayuki Noma, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto and Mitsuo Shimada : 微小環境におけるエクソソームを介した薬剤肝細胞癌の悪性度増強と耐性機序の解明, 第61回日本癌治療学会学術集会, Oct. 2023.
20.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Takayuki Noma and Mitsuo Shimada : 再発肝細胞癌に対する肝切除成績, 第61回日本癌治療学会学術集会, Oct. 2023.
21.	Kouzou Yoshikawa, Mitsuo Shimada, Yuji Morine, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuuma Wada and Toshiaki Yoshimoto : 大建中湯の消化器疾患における役割, 第98回中国四国外科学会総会第28回中国四国内視鏡外科研究会, Sep. 2023.
22.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Takayuki Noma and Mitsuo Shimada : 膵・胆管合流異常における胆道上皮PD-L1発現, 第46回日本膵・胆管合流異常研究会, Sep. 2023.
23.	Hiroki Teraoku, Yu Saitou, 杉本真樹, Yuji Morine, Shin-ichiro Yamada, Tetsuya Ikemoto and Mitsuo Shimada : 胆道手術における3D胆道造影Extended realityによる手術支援, 第17回肝癌治療ナビゲーション研究会, Aug. 2023.
24.	Yu Saitou, 杉本真樹, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 肝胆膵手術支援の新展開-Extended reality・ホログラム・メタバース-, 第50回日本膵切研究会, Aug. 2023.
25.	Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 症例, 第59回日本肝癌研究会, Jul. 2023.
26.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 肝細胞癌における微小環境クロストークによるLenvatinib耐性機序の検討, 第59回日本肝癌研究会, Jul. 2023.
27.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Yuhei Waki, Tetsuya Ikemoto and Mitsuo Shimada : 肉眼的門脈浸潤を伴う進行肝細胞癌の治療戦略, 第59回日本肝癌研究会, Jul. 2023.
28.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Shoko Yamashita and Koichi Tsuneyama : 組織発生学的特徴からみた肝内胆管癌の病理診断, 第59回日本肝癌研究会, Jul. 2023.
29.	Yuhei Waki, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Takayuki Noma, Tetsuya Ikemoto and Mitsuo Shimada : 内科的治療後再発・遺残肝細胞に対するRescue肝切除の意義, 第78回日本消化器外科学会総会, Jul. 2023.
30.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki and Hiroki Teraoku : 徳島大学病院全体と消化器・移植外科のFRT回避に係る連携とOODAループ, 第78回日本消化器外科学会総会, Jul. 2023.
31.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku, Takayuki Noma and Mitsuo Shimada : EOBによる肝予備能評価と最大腫瘍径×個数を用いた肝切除限界の提唱, 第78回日本消化器外科学会総会, Jul. 2023.
32.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Takayuki Noma and Mitsuo Shimada : 高齢者膵癌に対する膵頭十二指腸切除術の適応と限界, 第78回日本消化器外科学会総会, Jul. 2023.
33.	Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Sonoko Yasui-Yamada, Hiroshi Sakaue, 鎌田基夢, Tetsuya Matsuura and Mitsuo Shimada : 肥満を有する肝細胞癌患者に対する術前栄養運動介入の有用性 - ERAS導入による手術成績の向上 –, 第78回日本消化器外科学会総会, Jul. 2023.
34.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Yuhei Waki, Tetsuya Ikemoto and Mitsuo Shimada : 肉眼的門脈浸潤を伴う進行肝細胞癌の治療戦略, 第78回日本消化器外科学会総会, Jul. 2023.
35.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto, Sonoko Yasui-Yamada, Hiroshi Sakaue, 鎌田基夢, Tetsuya Matsuura and Mitsuo Shimada : 肥満を有する肝細胞癌患者に対する術前栄養運動介入の有用性-ERAS導入による手術成績の向上 –, 日本外科代謝栄養学会第60回学術集会, Jul. 2023.
36.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, 仲須千春 and Mitsuo Shimada : PD-L1 expression of biliary epithelium in pancreaticobiliary maljunction, 第35回日本肝胆膵外科学会学術集会, Jun. 2023.
37.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku and Mitsuo Shimada : New strategy for CRLM using Maximum Diameter x Number: MDN, 第35回日本肝胆膵外科学会学術集会, Jun. 2023.
38.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto, Shin-ichiro Yamada, 西麻希, Hiroshi Sakaue, 鎌田基夢, Tetsuya Matsuura and Mitsuo Shimada : Preoperative weight loss program for high body mass index patients undergoing liver resection for hepatocellular carcinoma - Surgical outcomes of ERAS protocol, 第35回日本肝胆膵外科学会学術集会, Jun. 2023.
39.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki and Hiroki Teraoku : Establishment of investigator initiated clinical trial as a future cell transplantation for to complement existing transplantations, 第35回日本肝胆膵外科学会学術集会, Jun. 2023.
40.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Yuhei Waki, Tetsuya Ikemoto and Mitsuo Shimada : Reconsideration of indication of hepatic for advanced hepatocellular carcinoma and significance of conversion surgery, 第35回日本肝胆膵外科学会学術集会, Jun. 2023.
41.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Takayuki Noma and Mitsuo Shimada : 肝細胞癌におけるNrf2/VEGFシグナルを介したTumor-associated macrophage (TAM)との相互作用, 第44回癌免疫外科研究会, Jun. 2023.
42.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 術前の心構え「AWA spirits」に基づいたtraining systemによる肝胆膵外科の若手教育, 日本消化器病学会四国支部第119回例会, Jun. 2023.
43.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : StageIII/IVa肝細胞癌におけるMRI拡散強調画像ADC値とTumor infiltrative lymphocyte (TIL), 第59回日本肝臓学会総会, Jun. 2023.
44.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞を用いた新たな肝細胞様細胞移植の樹立にむけて, 第59回日本肝臓学会総会, Jun. 2023.
45.	Yu Saitou, Yuji Morine and Mitsuo Shimada : 進行肝細胞癌に対する外科治療の新展開-肝癌微小環境におけるNrf2に着目した新たなアプローチ-, 第59回日本肝臓学会総会, Jun. 2023.
46.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 高齢者に対する肝胆膵手術におけるFrailtyの意義に関する検討, 第48回日本外科系連合学会学術集会, Jun. 2023.
47.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌における至適肝切除適応の再考とConversion surgeryの意義, 第48回日本外科系連合学会学術集会, Jun. 2023.
48.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Yu Saitou, Shin-ichiro Yamada and Hiroki Teraoku : 徳島大学病院における医療安全管理上の患者アドボカシーの実情と展望, 第48回日本外科系連合学会学術集会, Jun. 2023.
49.	Hiroki Mori, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku and Takayuki Noma : EOB予備能評価に基づいた至適肝切除, 第123回日本外科学会定期学術集会, Apr. 2023.
50.	Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 再生医療を用いたβ細胞補填治療法に関するFIH試験樹立に向けて, 第109回日本消化器病学会総会, Apr. 2023.
51.	仲須千春, Masaaki Nishi, Yuji Morine, Toshiaki Yoshimoto, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Chie Takasu, Hideya Kashihara, Yuuma Wada and Mitsuo Shimada : 青色LEDを用いたCAFの糖代謝に着目した腫瘍免疫制御のメカニズムの解明, 第123回日本外科学会定期学術集会, Apr. 2023.
52.	Takayuki Noma, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 再発肝細胞癌に対する肝切除の意義, 第123回日本外科学会定期学術集会, Apr. 2023.
53.	Hiroki Teraoku, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Sonoko Yasui-Yamada, 西麻希, Hiroshi Sakaue, 鎌田基夢, Tetsuya Matsuura and Mitsuo Shimada : 肝細胞癌における肥満患者への術前栄養運動介入の有用性, 第123回日本外科学会定期学術集会, Apr. 2023.
54.	Yuhei Waki, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and 仲須千春 : Lenvatinib耐性肝細胞癌における癌微小環境を介した悪性度獲得機序の解明, 第123回日本外科学会定期学術集会, Apr. 2023.
55.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Yuhei Waki, Hiroki Teraoku, Shin-ichiro Yamada and Yuji Morine : 再生医療によるインスリン産生細胞自家移植戦略は1型糖尿病治療を変える, 第123回日本外科学会定期学術集会, Apr. 2023.
56.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Yuhei Waki, Hiroki Teraoku and 仲須千春 : EOBによる肝予備能評価と最大腫瘍径×個数を用いた肝切除限界の提唱, 第123回日本外科学会定期学術集会, Apr. 2023.
57.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Takuya Tokunaga, Shin-ichiro Yamada, Hiroki Teraoku, Takashi Iwata and Mitsuo Shimada : 消化器外科ナビゲーションの新展開 -Extended reality・ホログラム・メタバース –, 第123回日本外科学会定期学術集会, Apr. 2023.
58.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌における至適肝切除適応の再考とConversion surgeryの意義, 第123回日本外科学会定期学術集会, Apr. 2023.
59.	Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 大腸癌肝転移における切除不能の定義とコンバージョンを目指した治療戦略, 第109回日本消化器病学会総会, Apr. 2023.
60.	Yuhei Waki, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : ADSCから分化したinsulin producing cell移植時の自己免疫による影響に関する検討, 第22回日本再生医療学会総会, Mar. 2023.
61.	Yu Saitou, 陳述海, Yuhei Waki, Tetsuya Ikemoto, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞を用いた新たな肝細胞様細胞移植の樹立にむけて, 第22回日本再生医療学会総会, Mar. 2023.
62.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Yuhei Waki, Hiroki Teraoku, Shin-ichiro Yamada and Yuji Morine : 間葉系幹細胞を用いた新たなβ細胞補填治療法樹立に向けて, 第22回日本再生医療学会総会, Mar. 2023.
63.	Yuhei Waki, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 再生医療によって作成されたinsulin producing cell移植後の自己免疫による影響に関する基礎的検討, 第50回日本膵・膵島移植学会学術集会, Mar. 2023.
64.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Yuhei Waki, Hiroki Teraoku, Yuuma Wada, Shin-ichiro Yamada and Yuji Morine : 再生医療を用いたβ細胞補填治療法に関する膵島移植とのクロストーク, 第50回日本膵・膵島移植学会学術集会, Mar. 2023.
65.	Hiroki Teraoku, Yuhei Waki, 仲須千春, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : Lenvatinib耐性肝細胞癌におけるNrf2を介した悪性度上昇と薬剤耐性獲得機序の検討, 第55回制癌剤適応研究会, Feb. 2023.
66.	Yuhei Waki, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : Lenvatinib耐性肝細胞癌における癌微小環境を介した悪性度獲得と薬剤耐性獲得機序の解明, 第27回日本肝がん分子標的治療研究会, Jan. 2023.
67.	Shin-ichiro Yamada, Yuji Morine, Yu Saitou, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 肝細胞癌BCLC intermediate stageにおけるMaximum tumor diameter × number の意義, 第27回日本肝がん分子標的治療研究会, Jan. 2023.
68.	Hiroki Mori, Yuji Morine, Hiroki Ishibashi, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Shoko Yamashita, Koichi Tsuneyama and Mitsuo Shimada : 慢性炎症状態の膵・胆管合流異常におけるNLRP3活性化を介した腫瘍微小環境と発癌に関する検討, 第33回日本消化器癌発生学会総会, Nov. 2022.
69.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Yuhei Waki, Takayuki Noma and Mitsuo Shimada : 大腸癌肝転移におけるoncological/liver functional resectabilityの定義と集学的治療戦略, 第84回日本臨床外科学会総会, Nov. 2022.
70.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する外科切除成績とConversion surgeryの意義, 第84回日本臨床外科学会総会, Nov. 2022.
71.	Tetsuya Ikemoto, Mitsuo Shimada, Shin-ichiro Yamada, Hiroki Teraoku, Yu Saitou and Yuji Morine : de novo B型肝炎管理体制構築に向けた取り組み, 第84回日本臨床外科学会総会, Nov. 2022.
72.	Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Sonoko Yasui-Yamada, 西麻希, Hiroshi Sakaue, 鎌田基夢, Tetsuya Matsuura and Mitsuo Shimada : 肥満を有する肝細胞癌患者に対する術前栄養運動介入の有用性, 第118回日本消化器病学会四国支部例会, Nov. 2022.
73.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, 仲須千春, 髙橋叡, Takayuki Noma and Mitsuo Shimada : StageIII/IV肝細胞癌における拡散強調画像ADC値の意義, 第33回日本消化器癌発生学会総会, Nov. 2022.
74.	Chie Takasu, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : 大腸癌肝転移における発育形式と予後に関する検討, 第84回日本臨床外科学会総会, Nov. 2022.
75.	Chie Takasu, 仲須千春, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Yuhei Waki and Mitsuo Shimada : Nrf2を基軸とした癌微小環境クロストークによる肝細胞癌Lenvatinib耐性機序解明に関する研究, 第33回日本消化器癌発生学会総会, Nov. 2022.
76.	Masaaki Nishi, 陳術海, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada : CAFの糖代謝を標的とした治療法の開発 -フラボノイド(EGCGとSudachitin)の可能性-, 第33回日本消化器癌発生学会総会, Nov. 2022.
77.	Masaaki Nishi, Chie Takasu, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Yuuma Wada, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : 漢方とBacterial translocation-大建中湯の消化管疾患に対する多面的効果の検討-, 第35回日本外科感染症学会総会学術集会, Nov. 2022.
78.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 肝細胞癌におけるlymphocyte/C-reactive protein ratio(LCR)の有用性, JDDW 2022, Oct. 2022.
79.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 高齢者膵癌切除例におけるフレイルの影響に関する検討, JDDW 2022, Oct. 2022.
80.	仲須千春, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yuhei Waki, Hiroki Teraoku and Mitsuo Shimada : 肝細胞癌におけるNrf2に着目したレンバチニブ耐性獲得機序についての検討, 第60回日本癌治療学会学術集会, Oct. 2022.
81.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, 仲須千春 and Mitsuo Shimada : 肝癌微小環境におけるNrf2/VEGFシグナルを介した肝癌細胞とTAMの相互作用, 第60回日本癌治療学会学術集会, Oct. 2022.
82.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, Toshiaki Yoshimoto, 西麻希, Hiroshi Sakaue and Mitsuo Shimada : 肥満肝細胞癌患者に対する術前栄養運動介入の有用性 -ERAS導入による手術成績の向上-, 第60回日本癌治療学会学術集会, Oct. 2022.
83.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 高齢者膵癌切除例の予後におけるフレイルの影響に関する検討, 第60回日本癌治療学会学術集会, Oct. 2022.
84.	Tetsuya Ikemoto, Takuya Tokunaga, Yuhei Waki, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Yuji Morine and Mitsuo Shimada : Schwann-like cell分化誘導による末梢神経損傷修復に関する基礎的検討, 第60回日本癌治療学会学術集会, Oct. 2022.
85.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する肝切除の意義, 第60回日本癌治療学会学術集会, Oct. 2022.
86.	Yuhei Waki, Yu Saitou, Tetsuya Ikemoto, 陳術海, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞から肝細胞様細胞の創出-肝不全・代謝性肝疾患に対する肝移植から細胞治療へ, 第58回日本移植学会総会, Oct. 2022.
87.	Yu Saitou, Mitsuo Shimada, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto and Yuji Morine : 脳死肝移植ドナー不足解消にむけての普及啓発活動 - 医療系学生に対するドナーアクション(命の授業)の必要性 –, 第58回日本移植学会総会, Oct. 2022.
88.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Hiroki Teraoku, Shin-ichiro Yamada and Yuji Morine : 再生医療を用いた移植治療確立へ向けた戦略∼新たなβ細胞補充治療法, 第58回日本移植学会総会, Oct. 2022.
89.	Hiroki Mori, Yuji Morine, Hiroki Ishibashi, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Shoko Yamashita, Koichi Tsuneyama and Mitsuo Shimada : 慢性炎症化下の膵・胆管合流異常におけるNLRP3活性化を介した腫瘍微小環境と発癌に関する検討, 第45回日本膵・胆管合流異常研究会, Sep. 2022.
90.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 肝細胞癌腫瘍微小環境におけるNrf2/VEGFシグナルを介した癌細胞とTAMの相互作用, 第81回日本癌学会学術総会, Sep. 2022.
91.	Takayuki Noma, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : 再発膵癌に対する残膵切除の治療成績, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, Sep. 2022.
92.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Takayuki Noma and Mitsuo Shimada : 大腸癌肝転移におけるresectabilityの定義と集学的治療戦略, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, Sep. 2022.
93.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : 術中ホログラム胆道造影を駆使した胆道手術支援, 第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, Sep. 2022.
94.	Yu Saitou, 杉本真樹, Yuji Morine, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto and Mitsuo Shimada : 術中ホログラム胆道造影を駆使した胆道手術支援, 第16回肝癌治療ナビゲーション研究会, Sep. 2022.
95.	Yuuma Wada, Masaaki Nishi, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Chie Takasu, Hideya Kashihara, Toshiaki Yoshimoto and Mitsuo Shimada : 癌関連線維芽細胞における糖代謝に着目した治療法の可能性, 第81回日本癌学会学術総会, Sep. 2022.
96.	Masaaki Nishi, Shuhai Chen, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada : CAFの糖代謝を標的とした治療法の開発-フラボノイド(EGCGとSudachitin)の可能性-, 第265回徳島医学会学術集会, Jul. 2022.
97.	仲須千春, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and 沖川昌平 : MRI拡散強調画像から見たミラノ基準内肝細胞癌の予後予測に関する検討, 第77回日本消化器外科学会総会, Jul. 2022.
98.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 膵癌残膵再発に対する残膵切除の治療成績, 第77回日本消化器外科学会総会, Jul. 2022.
99.	Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Toshiaki Yoshimoto, 西麻希, Hiroshi Sakaue and Mitsuo Shimada : 肥満を有する肝細胞癌患者に対する術前栄養運動介入の有用性, 第77回日本消化器外科学会総会, Jul. 2022.
100.	Tetsuya Ikemoto, Yu Saitou, Mitsuo Shimada, 沖川昌平, Hiroki Teraoku, Shin-ichiro Yamada and Yuji Morine : 再生医療を用いた細胞移植治療確立へ向けた戦略∼移植外科医・レシピエント双方の負担軽減という視点から, 第77回日本消化器外科学会総会, Jul. 2022.
101.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 大腸癌肝転移におけるoncological/liver functional resectabilityの定義とBRに対する集学的治療戦略, 第77回日本消化器外科学会総会, Jul. 2022.
102.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する肝切除の意義, 第77回日本消化器外科学会総会, Jul. 2022.
103.	Chie Takasu, 仲須千春, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Yasuhiro Hamada, 沖川昌平 and Mitsuo Shimada : 肝細胞癌におけるmiRNA-132, 142-5pを介したLenvatinib耐性機序の検討, 第77回日本消化器外科学会総会, Jul. 2022.
104.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 肝細胞癌におけるSorafenib/Lenvatinib耐性機序の検討, 第26回日本肝がん分子標的治療研究会, Jun. 2022.
105.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, 宮崎克己, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する外科切除成績とConversion surgeryの意義, 第26回日本肝がん分子標的治療研究会, Jun. 2022.
106.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する肝切除を中心とした治療戦略, 第31回日本癌病態治療研究会, Jun. 2022.
107.	Yu Saitou, Yuji Morine, Shin-ichiro Yamada, Hiroki Teraoku, 宮崎克己, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する外科切除成績とConversion surgeryの意義, 第117回日本消化器病学会四国支部例会, Jun. 2022.
108.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Yu Saitou, Shin-ichiro Yamada and Hiroki Teraoku : 消化器・移植外科から発信する手術室医療安全, 第47回日本外科系連合学会学術集会, Jun. 2022.
109.	Hiroki Teraoku, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, 沖川昌平, Tetsuya Ikemoto and Mitsuo Shimada : Associations between the ADC values based on MRI diffusion-weighted images and tumor-infiltrative lymphocytes in Stage III / IV hepatocellular carcinoma, 第34回日本肝胆膵外科学会・学術集会, Jun. 2022.
110.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : Impact of frailty on resected pancreatic cancer in elderly patients, 第34回日本肝胆膵外科学会・学術集会, Jun. 2022.
111.	Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Masaaki Nishi, Hiroshi Sakaue and Mitsuo Shimada : Weight loss program for high body mass index patients undergoing liver resection for hepatocellular carcinoma, 第34回日本肝胆膵外科学会・学術集会, Jun. 2022.
112.	Tetsuya Ikemoto, Yu Saitou, Mitsuo Shimada, Hiroki Teraoku, Shin-ichiro Yamada and Yuji Morine : Establishment of investigator initiated clinical trial for insulin producing cells from ADSC with Tokushima protocol to complement pancreas/islet transplantation., 第34回日本肝胆膵外科学会・学術集会, Jun. 2022.
113.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : Role of surgical resection for advanced hepatocellular carcinoma focused on conversion surgery in MTA era, 第34回日本肝胆膵外科学会・学術集会, Jun. 2022.
114.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Takuya Tokunaga, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : 術中ホログラム胆道造影を駆使した胆道手術支援, 第31回日本コンピュータ外科学会大会, Jun. 2022.
115.	Hiroki Teraoku, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, 沖川昌平, Tetsuya Ikemoto and Mitsuo Shimada : Significance of the ADC values based on MRI DWI in Stage / HCC, 第67回国際外科学会日本部会総会, Jun. 2022.
116.	Yuji Morine, Yu Saitou and Mitsuo Shimada : 進行肝細胞癌に対する集学的治療におけるConversion surgeryの意義, 第58回日本肝臓学会総会, Jun. 2022.
117.	Chie Takasu, 仲須千春, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, 沖川昌平 and Mitsuo Shimada : 肝細胞癌におけるmiRNA-X,Yを介したLenvatinib耐性機序の検討, 第26回日本肝がん分子標的治療研究会, Jun. 2022.
118.	Hiroki Mori, Shoko Yamashita, Yuji Morine, Hiroki Ishibashi, Koichi Tsuneyama and Mitsuo Shimada : 膵・胆管合流異常におけるNLRP3活性化を介した腫瘍微小環境と発癌に関する検討, 第59回日本小児外科学会学術集会, May 2022.
119.	Hiroki Ishibashi, Yuji Morine, Yu Saitou, Hiroki Mori, Noriko Yokota and Mitsuo Shimada : 小児膵SPNに対する腹腔鏡下脾温存膵体尾部切除術, 第59回日本小児外科学会学術集会, May 2022.
120.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 症例, 第58回日本肝癌研究会, May 2022.
121.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, 沖川昌平 and Mitsuo Shimada : 大腸癌肝転移におけるoncological/liver functional resectabilityの定義とBRに対する集学的治療戦略, 第58回日本肝癌研究会, May 2022.
122.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する肝切除の意義, 第58回日本肝癌研究会, May 2022.
123.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : 術中ホログラム胆道造影を駆使した肝胆道手術支援, 第58回日本肝癌研究会, May 2022.
124.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Tetsuya Ikemoto and Mitsuo Shimada : 再発肝細胞癌に対する肝切除の意義, 第58回日本肝癌研究会, May 2022.
125.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, 沖川昌平 and 山下祥子 : 高齢者膵癌切除例におけるフレイルの影響に関する検討, 第108回日本消化器病学会総会, Apr. 2022.
126.	Yuji Morine, Yu Saitou and Mitsuo Shimada : 進行肝細胞癌に対する集学的治療におけるConversion Surgeryの意義, 第108回日本消化器病学会総会, Apr. 2022.
127.	髙橋叡, Hiroki Teraoku, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, 沖川昌平, Tetsuya Ikemoto and Mitsuo Shimada : Stage III/IV 肝細胞癌におけるMRI拡散強調画像をもとにしたADC値の有用性に関する検討, 第122回日本外科学会定期学術集会, Apr. 2022.
128.	仲須千春, 山下祥子, Yuji Morine and Shin-ichiro Yamada : 肝細胞癌の腫瘍微小環境形成における癌関連線維芽細胞の役割, 第122回日本外科学会定期学術集会, Apr. 2022.
129.	Hiroki Teraoku, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, 沖川昌平, Tetsuya Ikemoto and Mitsuo Shimada : Borderline resectableに着目した切除可能分類に基づく膵癌治療成績に関する検討, 第122回日本外科学会定期学術集会, Apr. 2022.
130.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, 沖川昌平 and Mitsuo Shimada : 膵癌切除例における早期再発の危険因子に関する検討, 第122回日本外科学会定期学術集会, Apr. 2022.
131.	荒川悠佑, Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 切除可能膵癌における術後予後予測因子としてのCRP・アルブミン比(CAR)の有用性, 第122回日本外科学会定期学術集会, Apr. 2022.
132.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, 宮崎克己 and Mitsuo Shimada : 術中ホログラム胆道造影を駆使した胆道手術支援, 第122回日本外科学会定期学術集会, Apr. 2022.
133.	Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, 沖川昌平, Hiroki Teraoku, Shin-ichiro Yamada and Yuji Morine : 自己脂肪から作成したインスリン産生細胞自家移植が拓く再生医療の未来, 第122回日本外科学会定期学術集会, Apr. 2022.
134.	Yuuma Wada, Masaaki Nishi, 陳術海, Yuji Morine, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto, 山下祥子, 岩川陽介 and Mitsuo Shimada : 癌関連線維芽細胞の糖代謝を標的とした治療法の開発, 第122回日本外科学会定期学術集会, Apr. 2022.
135.	Chie Takasu, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, 沖川昌平 and Mitsuo Shimada : 間葉系幹細胞から肝細胞様細胞の誘導におけるNrf2の働きに関する検討, 第122回日本外科学会定期学術集会, Apr. 2022.
136.	沖川昌平, Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, 山下祥子 and Yuji Morine : Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討, 第122回日本外科学会定期学術集会, Apr. 2022.
137.	Tetsuya Ikemoto, Takuya Tokunaga, Yu Saitou, Shohei Okikawa, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞から分化誘導したSchwann-like cellに関する研究, 第21回日本再生医療学会総会, Mar. 2022.
138.	Chie Takasu, Yuji Morine, Kouzou Yoshikawa, Toshihiro Nakao, Masaaki Nishi, Takuya Tokunaga, Hideya Kashihara, Yuuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada : 腸管Microbiome解析からみた大建中湯の消化管疾患に対する多面的効果の検討, 第18回日本消化管学会総会学術集会(GI Week 2022), Feb. 2022.
139.	Shohei Okikawa, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, NAKASU Chiharu and Mitsuo Shimada : VEGF阻害はTAMの機能を減弱させる, 第25回日本肝がん分子標的治療研究会, Jan. 2022.
140.	Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 肝癌微小環境においてTAMを介したNrf2/VEGFシグナルが悪性度増強に関与する, 第44回日本肝臓学会西部会, Dec. 2021.
141.	Yu Saitou, Yuji Morine and Mitsuo Shimada : 肝内胆管癌におけるMRI拡散強調画像を用いた新たな予後予測, 第44回日本肝臓学会西部会, Dec. 2021.
142.	Yuji Morine, Yu Saitou and Mitsuo Shimada : 進行肝細胞癌に対する集学的治療におけるConversion surgeryの意義, 第44回日本肝臓学会西部会, Dec. 2021.
143.	Hiroki Teraoku, Yuji Morine, Shin-ichiro Yamada, Tetsuya Ikemoto, Yu Saitou and Mitsuo Shimada : 腹腔鏡下膵体尾部切除の手術手技と定型化, 第34回日本内視鏡外科学会総会, Dec. 2021.
144.	Chie Takasu, Gao Luping, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shohei Okikawa, Katsuki Miyazaki and Mitsuo Shimada : Nrf2を介した微小環境クロストークによる肝細胞癌薬剤耐性機序解明に関する研究, 第32回日本消化器癌発生学会総会, Nov. 2021.
145.	Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Masaaki Nishi, Chie Takasu, Yuuma Wada, Toshiaki Yoshimoto, Shoko Yamashita, IWAKAWA Yosuke and Yuji Morine : Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討, 第83回日本臨床外科学会総会, Nov. 2021.
146.	Chie Takasu, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Mitsuo Shimada : 大腸癌肝転移における免疫逃避機構の働き, 第83回日本臨床外科学会総会, Nov. 2021.
147.	Shohei Okikawa, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Katsuki Miyazaki, NAKASU Chiharu and Mitsuo Shimada : VEGF阻害はTAMの悪性度を減じる, 第32回日本消化器癌発生学会総会, Nov. 2021.
148.	Hiroki Teraoku, Gao Luping, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 肝細胞癌におけるNrf2-PINK-1axisを介したLenvatinib耐性機序の検討, 第32回日本消化器癌発生学会総会, Nov. 2021.
149.	Shin-ichiro Yamada, Gao Luping, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shohei Okikawa, Katsuki Miyazaki and Mitsuo Shimada : ソラフェニブ耐性肝細胞癌の腫瘍微小環境形成におけるBAFF/BAFF受容体の役割, 第32回日本消化器癌発生学会総会, Nov. 2021.
150.	Shin-ichiro Yamada, Gao Luping, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shohei Okikawa and Mitsuo Shimada : 肝細胞癌におけるソラフェニブ耐性獲得機序に関する検討, 第32回日本消化器癌発生学会総会, Nov. 2021.
151.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Takuya Tokunaga, Shin-ichiro Yamada, Hiroki Teraoku, Takashi Iwata and Mitsuo Shimada : 消化器外科におけるホログラム次世代手術支援, 第30回日本コンピュータ外科学会大会, Nov. 2021.
152.	Hiroki Teraoku, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : One stop shop を目指したEOB-MRIによる部分肝機能評価，切除限界予測と腫瘍悪性度の評価に関する検討, 第116回日本消化器病学会四国支部例会, Nov. 2021.
153.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 再発膵癌に対する残膵切除の治療成績, 第83回日本臨床外科学会総会, Nov. 2021.
154.	Yu Saitou, 杉本真樹, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki and Mitsuo Shimada : Extended reality(VR・AR・MR)を駆使した手術ナビゲーション, 第83回日本臨床外科学会総会, Nov. 2021.
155.	Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 徳島大学の肝胆膵外科における若手教育, 第83回日本臨床外科学会総会, Nov. 2021.
156.	Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki and Mitsuo Shimada : 地方から世界に通用する一流の外科医を目指した取り組み, 第83回日本臨床外科学会総会, Nov. 2021.
157.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Tetsuya Ikemoto and Mitsuo Shimada : 進行肝細胞癌に対する外科切除成績とConversion surgeryの意義, 第83回日本臨床外科学会総会, Nov. 2021.
158.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Yu Saitou, Shin-ichiro Yamada and Hiroki Teraoku : 外科医をも守る消化器・移植外科から発信する手術室医療安全, 第83回日本臨床外科学会総会, Nov. 2021.
159.	Shoko Yamashita, Yuji Morine, Hiroki Ishibashi, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yu Saitou, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : 膵・胆管合流異常におけるNLRP3を介した腫瘍微小環境と発癌に関する検討, 第57回日本胆道学会学術集会, Oct. 2021.
160.	Shohei Okikawa, Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Katsuki Miyazaki and Mitsuo Shimada : DWI-MRIによる進行胆嚢癌の腫瘍悪性度評価, 第57回日本胆道学会学術集会, Oct. 2021.
161.	Shin-ichiro Yamada, Katsuki Miyazaki, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Shohei Okikawa, Shoko Yamashita and Mitsuo Shimada : 肝内胆管癌予後規定因子としての腫瘍浸潤リンパ球の意義, 第57回日本胆道学会学術集会, Oct. 2021.
162.	Shohei Okikawa, Yuji Morine, Shin-ichiro Yamada, Tetsuya Ikemoto and Mitsuo Shimada : VEGF inhibition reduce TAM's malignant potential, 第80回日本癌学会学術総会, Sep. 2021.
163.	Shin-ichiro Yamada, Gao Luping, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shohei Okikawa, Shoko Yamashita, Katsuki Miyazaki and Mitsuo Shimada : The role of BAFF/BAFF receptor in microenvironment of sorafenib resistant he patocellular carcinoma, 第80回日本癌学会学術総会, Sep. 2021.
164.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki and Mitsuo Shimada : 生体肝移植術後短期長期成績に関する検討, 第57回日本移植学会総会, Sep. 2021.
165.	Hiroki Teraoku, Yu Saitou, Tetsuya Ikemoto, Katsuki Miyazaki, Shin-ichiro Yamada, Yuji Morine, Masato Miyake, Seiichi Oyadomari and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞を基にした機能的肝細胞様細胞の分化誘導, 第57回日本移植学会総会, Sep. 2021.
166.	Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki, Shohei Okikawa, Hiroki Teraoku, Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 再生医療を用いたインスリン産生細胞自家移植による1型糖尿病根治治療確立へ向けた戦略, 第57回日本移植学会総会, Sep. 2021.
167.	Shin-ichiro Yamada, Yu Saitou, Yuji Morine, Tetsuya Ikemoto, Hiroki Teraoku, 杉本真樹 and Mitsuo Shimada : Extended reality(VR・AR・MR)を駆使した手術ナビゲーション-マイクロ波手術デバイスAcrosurg®使用経験も含めて-, 第15回肝がんナビゲーション研究会, Sep. 2021.
168.	Mayu Ohhra, Hisami Okumura, 平山明由, Hana Kawakami, 多々納浩, Yuji Morine, Hirokazu Ohminami, Masashi Masuda, Mitsuo Shimada, 曽我朋義, 冨田勝 and Yutaka Taketani : メタボローム解析を用いた肝切除術による肝臓のアミノ酸代謝物の変化, 第 13 回日本臨床栄養代謝学会中国四国支部学術集会, Aug. 2021.
169.	Yu Saitou, Tetsuya Ikemoto, Katsuki Miyazaki, Kazunori Tokuda, Shin-ichiro Yamada, Satoru Imura, Yuji Morine, Masato Miyake, Seiichi Oyadomari and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞から肝細胞様細胞の創出-肝不全・代謝性肝疾患に対する肝移植から細胞治療へ-, 第263回徳島医学会学術集会(令和3年度夏期), Aug. 2021.
170.	Mayu Ohhra, Hisami Okumura, 平山明由, Hana Kawakami, 多々納浩, Yuji Morine, Hirokazu Ohminami, Masashi Masuda, Mitsuo Shimada, 曽我朋義, 冨田勝 and Yutaka Taketani : メタボローム解析を用いた肝切除術による肝臓の代謝物変化の検討, 第75回日本栄養・食糧学会大会, Jul. 2021.
171.	Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Toshiaki Yoshimoto and Yuji Morine : Duodenal-jejunal bypassの術後早期血糖抑制効果に関する検討, 第76回日本消化器外科学会総会, Jul. 2021.
172.	Shin-ichiro Yamada, Gao Luping, Yuji Morine, Katsuki Miyazaki, Kazunori Tokuda, Shohei Okikawa, Yu Saitou, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : ソラフェニブ耐性肝細胞癌の腫瘍微小環境形成におけるBAFF/BAFF受容体の役割, 第57回日本肝癌研究会, Jul. 2021.
173.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki and Mitsuo Shimada : DAA治療後SVR症例は発癌Potentialが高く進行病期に関与する, 第57回日本肝癌研究会, Jul. 2021.
174.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 進行肝細胞癌集学的治療における外科切除の役割:Conversion Surgery成績も含めて, 第57回日本肝癌研究会, Jul. 2021.
175.	TAKAHASHI Akira, Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Katsuki Miyazaki and Mitsuo Shimada : DWI-MRIによる進行胆嚢癌の腫瘍悪性度評価, 第76回日本消化器外科学会総, Jul. 2021.
176.	NAKASU Chiharu, Tetsuya Ikemoto, Takuya Tokunaga, Katsuki Miyazaki, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞からSchwann-like cellの効果的分化誘導方法の研究, 第76回日本消化器外科学会総会, Jul. 2021.
177.	Shoko Yamashita, Yuji Morine, Hiroki Ishibashi, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yu Saitou, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : 膵・胆管合流異常におけるNLRP3活性化と発癌に関する検討, 第76回日本消化器外科学会総会, Jul. 2021.
178.	Katsuki Miyazaki, Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shoko Yamashita, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : 肝内胆管癌予後規定因子としての腫瘍浸潤リンパ球の意義, 第76回日本消化器外科学会総会, Jul. 2021.
179.	Kazunori Tokuda, Yuji Morine, Katsuki Miyazaki, Shoko Yamashita, Shohei Okikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 肝細胞癌の腫瘍微小環境におけるOsteopontinを介したCAF-TAM interactionについての検討, 第76回日本消化器外科学会総会, Jul. 2021.
180.	Yuuma Wada, Yuji Morine, Yu Saitou, Satoru Imura, Tetsuya Ikemoto, Masaaki Nishi, Shin-ichiro Yamada, Kazunori Tokuda, Hiroki Teraoku and Mitsuo Shimada : 癌微小環境における大建中湯の癌細胞増殖抑制効果, 第76回日本消化器外科学会総会, Jul. 2021.
181.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Shoko Yamashita, Katsuki Miyazaki and Mitsuo Shimada : 高齢者に対する肝胆膵手術におけるFrailtyの意義に関する検討, 第76回日本消化器外科学会総会, Jul. 2021.
182.	Yu Saitou, Maki Sugimoto, Yuji Morine, Tetsuya Ikemoto, Takuya Tokunaga, Hiroki Teraoku, Katsuki Miyazaki, Takashi Iwata and Mitsuo Shimada : Navigation of rectal and hepatobiliary pancreatic surgery with intraoperative hologram, 第76回日本消化器外科学会総会, Jul. 2021.
183.	Tetsuya Ikemoto, Kazunori Tokuda, Yu Saitou, Katsuki Miyazaki, Hiroki Teraoku, Shohei Okikawa, Shin-ichiro Yamada, Satoru Imura and Yuji Morine : 消化器外科領域の幹細胞トランスレーショナルリサーチにおける医工連携, 第76回日本消化器外科学会総会, Jul. 2021.
184.	Hiroki Teraoku, Yuji Morine, Shin-ichiro Yamada, Katsuki Miyazaki, Yu Saitou, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 両葉多発大腸癌肝転移に対する肝切除適応基準とConversion Surgery, 第76回日本消化器外科学会総会, Jul. 2021.
185.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 進行肝細胞癌集学的治療における外科切除の役割:Conversion Surgery成績も含めて, 第76回日本消化器外科学会総会, Jul. 2021.
186.	Shin-ichiro Yamada, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Hiroki Teraoku, Shoko Yamashita, Katsuki Miyazaki and Mitsuo Shimada : 高齢者に対する肝胆膵手術におけるFrailtyの意義に関する検討, 第115回日本消化器病学会四国支部例会, Jun. 2021.
187.	Shin-ichiro Yamada, Yuji Morine and Mitsuo Shimada : 切除不能肝細胞癌に対するConversion・Salvage surgeryを目指した治療戦略, 第57回日本肝臓学会総会, Jun. 2021.
188.	Yu Saitou, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞から肝細胞様細胞の創出- 肝不全・代謝性肝疾患に対する肝移植から細胞移植へ –, 第57回日本肝臓学会総会, Jun. 2021.
189.	Katsuki Miyazaki, Yu Saitou, Mayuko Shimizu, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : 小胞体ストレス応答に着目した非アルコール性脂肪肝炎の肝切除後肝再生/肝不全に関する研究, 第47回日本急性肝不全研究会, Jun. 2021.
190.	Katsuki Miyazaki, Yu Saitou, Mayuko Shimizu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Kazunori Tokuda, Koichi Tsuneyama and Mitsuo Shimada : Endoplasmic reticulum stress response deficiency is a major cause of poor liver regeneration after hepatectomy in nonalcoholic steatohepatitis, 第33回日本肝胆膵外科学会学術集会, Jun. 2021.
191.	Hiroki Teraoku, Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Katsuki Miyazaki : Significance of frailty for eldery patients in HPB surgery, 第33回日本肝胆膵外科学会学術集会, Jun. 2021.
192.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Kazunori Tokuda, Hiroki Teraoku, Shohei Okikawa, Shoko Yamashita, Katsuki Miyazaki and Mitsuo Shimada : Treatment strategy of multiple colorectal liver metastasis-Criteria for upfront surgery and Conversion Surgery-, 第33回日本肝胆膵外科学会学術集会, Jun. 2021.
193.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Hiroki Teraoku, Maki Sugimoto and Mitsuo Shimada : Intraoperative support with 3D holographic cholangiography in biliary surgery, 第33回日本肝胆膵外科学会学術集会, Jun. 2021.
194.	Yuji Morine, Hiroki Ishibashi, Hiroki Mori, T Araida, Mitsuo Shimada and H Fujii : Short-and long-term outcomes after surgical treatment of pancreaticobiliary maljunction:JSPBM nationwide survey data, 第33回日本肝胆膵外科学会学術集会, Jun. 2021.
195.	Tetsuya Ikemoto, Kazunori Tokuda, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Katsuki Miyazaki : Clinical application of auto-transplantation of generated insulin-producing cells from ADSC with Tokushima protocol, 第33回日本肝胆膵外科学会学術集会, Jun. 2021.
196.	Katsuki Miyazaki, Yu Saitou, Mayuko Shimizu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Koichi Tsuneyama and Mitsuo Shimada : 非アルコール性脂肪性肝疾患(NAFLD)における肝切除後肝再生機能不全に関する研究- 小胞体ストレス応答不全の観点より -, 第 121 回日本外科学会定期学術集会, Apr. 2021.
197.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Katsuki Miyazaki, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 肝門部領域胆管癌の切除成績と術後補助療法の意義, 第121回日本外科学会定期学術集会, Apr. 2021.
198.	Hiroki Mori, Yuji Morine, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常の胆道癌発癌機構にNrf2依存的インフラマソーム活性化が関与する, 第58回日本小児外科学会学術集会, Apr. 2021.
199.	Hiroki Mori, Yuji Morine, Noriko Yokota, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常におけるNrf2依存的インフラマソーム活性化を介した胆道癌発癌機構に関する検討, 第121回日本外科学会定期学術集会, Apr. 2021.
200.	Toshiaki Yoshimoto, Mitsuo Shimada, Yuji Morine, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Shohei Eto and Shohei Okikawa : 大腸癌および腫瘍微小環境に対する青色LEDの効果, 第121回日本外科学会定期学術集会, Apr. 2021.
201.	Kanto Yamasaki, Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : 術中Real-time 3D胆管造影を併用した胆道手術, 第121回日本外科学会定期学術集会, Apr. 2021.
202.	TAKAHASHI Akira, Yu Saitou, Tetsuya Ikemoto, Kazunori Tokuda, Katsuki Miyazaki, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞ADSCからのSuper HLC (肝細胞様細胞)の創出, 第121回日本外科学会定期学術集会, Apr. 2021.
203.	Kazunori Tokuda, Tetsuya Ikemoto, Katsuki Miyazaki, Shoko Yamashita, Shohei Okikawa, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : Adipose derived stem cellから作製したInsulin producing cellの臨床応用に向けた保存方法に関する研究, 第121回日本外科学会定期学術集会, Apr. 2021.
204.	Yu Saitou, Tetsu Tomonari, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Tetsuji Takayama and Mitsuo Shimada : 進行肝細胞癌に対する集学的治療 - 分子標的治療薬使用によるConversion Surgery –, 第121回日本外科学会定期学術集会, Apr. 2021.
205.	Shoko Yamashita, Yuji Morine, Hiroki Ishibashi, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yu Saitou, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : 膵・胆管合流異常における腫瘍微小環境と発癌に関する検討, 第121回日本外科学会定期学術集会, Apr. 2021.
206.	Hiroki Teraoku, Gao Luping, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita and Katsuki Miyazaki : 肝細胞癌におけるSorafenib耐性獲得機序に関する検討, 第121回日本外科学会定期学術集会, Apr. 2021.
207.	Shohei Okikawa, Yuji Morine, Kazunori Tokuda, Yu Saitou, Shin-ichiro Yamada, Shoko Yamashita, Katsuki Miyazaki, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 腫瘍微小環境におけるOsteopontinの意義, 第121回日本外科学会定期学術集会, Apr. 2021.
208.	Shin-ichiro Yamada, 陳術海, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita and Katsuki Miyazaki : 肝細胞癌微小環境におけるPAI-1発現の意義に関する検討, Apr. 2021.
209.	Tetsuya Ikemoto, Mitsuo Shimada, Kazunori Tokuda, Katsuki Miyazaki, Shin-ichiro Yamada, Yu Saitou, Satoru Imura and Yuji Morine : 再生医療を用いたインスリン枯渇状態の患者に対する自律的インスリン分泌細胞自己移植に関するAMED橋渡し研究, 第121回日本外科学会定期学術集会, Apr. 2021.
210.	Kazunori Tokuda, Tetsuya Ikemoto, Katsuki Miyazaki, Shoko Yamashita, Shohei Okikawa, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞から作製したインスリン産生細胞の至適保存方法に関する研究, 第20回日本再生医療学会総会, Mar. 2021.
211.	Yu Saitou, Tetsuya Ikemoto, Katsuki Miyazaki, Kazunori Tokuda, Shin-ichiro Yamada, Satoru Imura, Yuji Morine, Masato Miyake, Seiichi Oyadomari and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞から肝細胞様細胞の創出, 第20回日本再生医療学会総会, Mar. 2021.
212.	Tetsuya Ikemoto, Takuya Tokunaga, Shohei Okikawa, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞から分化誘導したSchwann-like cellの基礎的検討, 第20回日本再生医療学会総会, Mar. 2021.
213.	Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Katsuki Miyazaki, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 徳島大学の肝胆膵外科における若手教育-特に内視鏡手術に焦点をあてて-, 第33回日本内視鏡外科学会, Mar. 2021.
214.	Yu Saitou, Tetsuya Ikemoto, Katsuki Miyazaki, Kazunori Tokuda, Shin-ichiro Yamada, Satoru Imura, Yuji Morine, Masato Miyake, Seiichi Oyadomari and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞から肝細胞様細胞の創出- 肝不全・代謝性肝疾患に対する肝移植から細胞治療へ -, 第262回徳島医学会学術集会, Mar. 2021.
215.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : Significance of frailty for elderly patients in HPB surgery, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
216.	Yu Saitou, Tetsuya Ikemoto, Yusuke Arakawa, Luping Gao, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : Effective 3D culture of hepatocyte like cells human adipose derived mesenchymal stem cells, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
217.	Yu Saitou, Tetsuya Ikemoto, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki, Maki Sugimoto and Mitsuo Shimada : Intraoperative support with 3D holographic cholangiography and indocyanine green navigation, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
218.	Katsuki Miyazaki, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Masato Yoshikawa and Mitsuo Shimada : The impact of frailty as a prognostic factor of colorectal liver metastasis, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
219.	Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : The value of CRP albumin ratio in patient with resectable pancreas cancer, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
220.	Tetsuya Ikemoto, Kazunori Tokuda, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Katsuki Miyazaki : Basic research for aiming non-clinical PoC acquisition of insulin producing cells from ADSC with Tokushima protocol, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
221.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : Optimal surgical treatment including lymph nodes dissection and adjuvant chemotherapy for intrahepatic cholangiocarcinoma, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
222.	Satoru Imura, Katsuki Miyazaki, Masato Yoshikawa, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Standardization and stepwise training for safe laparoscopic hepatectomy, 第32回日本肝胆膵外科学会学術集会, Feb. 2021.
223.	Shin-ichiro Yamada, 高露泙, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita and Katsuki Miyazaki : 肝細胞癌におけるSorafenib耐性獲得機序に関する検討, 第23回日本肝がん分子標的治療研究会, Jan. 2021.
224.	Yu Saitou, Tetsu Tomonari, Shin-ichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Yuji Morine, Tetsuji Takayama and Mitsuo Shimada : 進行肝細胞癌に対する集学的治療-分子標的治療薬使用によるConversion Surgery-, 第23回日本肝がん分子標的治療研究会, Jan. 2021.
225.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa, Kazunori Tokuda and Katsuki Miyazaki : 肝胆膵領域悪性腫瘍におけるNrf2・VEGFに着目した腫瘍関連マクロファージ活性化についての検討, 第29回日本癌病態治療研究, Jan. 2021.
226.	Yu Saitou, 高露萍, Tetsuya Ikemoto, Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : GSK3 inhibitorsを用いた脂肪由来間葉系幹細胞から肝細胞様細胞への3次元分化誘導, 第38回日本肝移植学会学術集, Dec. 2020.
227.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki, 杉本真樹 and Mitsuo Shimada : Hologramを用いた術中手術支援-術中Real-time3D胆管造影を併用した胆道手術-, 第45回日本外科系連合学会学術集会, Dec. 2020.
228.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : 肝細胞癌に対する肝切除術におけるFrailtyの意義に関する検討, 第56回日本肝癌研究会, Dec. 2020.
229.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : DAA治療後SVR症例は発癌Potentialが高く進行病期に関与する, 第56回日本肝癌研究会, Dec. 2020.
230.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Katsuki Miyazaki : 大腸癌同時性肝転移に対する治療戦略-肝切除適応基準とConversion Surgery-, 第56回日本肝癌研究会, Dec. 2020.
231.	Katsuki Miyazaki, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou and Shin-ichiro Yamada : 肝内胆管癌予後規定因子としてのLymphocyte / CRP ratio (LCR)の意義, 第75回日本消化器外科学会総会, Dec. 2020.
232.	Toshiaki Yoshimoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki, Yukako Takehara and Mitsuo Shimada : 膵切除周術期における栄養指標からみた人工膵臓の有用性, 第75回日本消化器外科学会総会, Dec. 2020.
233.	Masato Yoshikawa, Yuji Morine, Shin-ichiro Yamada, Katsuki Miyazaki, Kazunori Tokuda, Yu Saitou, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : DWI-MRIのADC値を用いた転移性肝癌の切除後予後予測，抗癌剤効果予測に関する検討, 第75回日本消化器外科学会総会, Dec. 2020.
234.	Kazunori Tokuda, Yuji Morine, Shin-ichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : 転移性肝癌切除症例におけるFrailの重要性についての検討, 第75回日本消化器外科学会総会, Dec. 2020.
235.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : 胆嚢癌の悪性度評価におけるADCの有用性に関する検討, 第75回日本消化器外科学会総会, Dec. 2020.
236.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : DAA治療後SVR症例は発癌Potentialが高く進行病期に関与する, 第75回日本消化器外科学会総会, Dec. 2020.
237.	Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 当院の肝胆膵手術症例におけるSSIサーベイランスによる検討, 第75回日本消化器外科学会総会, Dec. 2020.
238.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Katsuki Miyazaki : 長期予後と患者QoLに着目した膵全摘症例の検討, 第75回日本消化器外科学会総会, Dec. 2020.
239.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Katsuki Miyazaki : 大腸癌同時性肝転移に対する治療戦略-肝切除適応基準とConversion Surgery-, 第75回日本消化器外科学会総会, Dec. 2020.
240.	Satoru Imura, Katsuki Miyazaki, Masato Yoshikawa, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 腹腔鏡下肝左葉切除の標準化への取り組み ∼手技定型化とstepwise training∼, 第75回日本消化器外科学会総会, Dec. 2020.
241.	Toshiaki Yoshimoto, Mitsuo Shimada, Yuji Morine, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Shohei Eto and Shohei Okikawa : 青色LEDによる大腸癌の光受容体をターゲットとする治療法の開発, 第31回日本消化器癌発生学会総会, Nov. 2020.
242.	Katsuki Miyazaki, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Takeshi Oya, Koichi Tsuneyama and Mitsuo Shimada : 肝内胆管癌予後規定因子としてのリンパ球CRP比の意義と腫瘍浸潤リンパ球との関係, 第31回日本消化器癌発生学会総会, Nov. 2020.
243.	Shin-ichiro Yamada, 高露萍, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki and Mitsuo Shimada : ソラフェニブ耐性肝癌において，Nrf2は幹細胞性・遊走能・ABCトランスポーター発現を促進する, 第31回日本消化器癌発生学会総会, Nov. 2020.
244.	Yuji Morine, Hiroki Mori, Yu Saitou, Shin-ichiro Yamada, Tetsuya Ikemoto, Satoru Imura, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常の発癌メカニズムに関する基礎研究:徳島大学の場合, 第43回日本膵・胆管合流異常研究会, Nov. 2020.
245.	Katsuki Miyazaki, Yu Saitou, 高露萍, Tetsuya Ikemoto, Shin-ichiro Yamada, Satoru Imura, Yuji Morine, Masato Miyake, Seiichi Oyadomari and Mitsuo Shimada : ヒト脂肪由来間葉系幹細胞から分化誘導した肝細胞様細胞の遺伝子発現解析, 第56回日本移植学会総会, Nov. 2020.
246.	Kazunori Tokuda, Tetsuya Ikemoto, Katsuki Miyazaki, Shohei Okikawa, Shin-ichiro Yamada, Yu Saitou, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞から分化誘導したインスリン産生細胞の凍結保存方法についての検討, 第56回日本移植学会総会, Nov. 2020.
247.	Tetsuya Ikemoto, Kazunori Tokuda, Yu Saitou, Katsuki Miyazaki, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : 移植医から提案する再生医療技術を用いたインスリン産生細胞自家移植による1型糖尿病根治へ向けた戦略, 第56回日本移植学会総会, Nov. 2020.
248.	Yu Saitou, Satoru Imura, Katsuki Miyazaki, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 医療系学生に対するDonor Action(命の授業)の必要性, 第56回日本移植学会総会, Oct. 2020.
249.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki and Mitsuo Shimada : 膵癌切除症例における，Frailtyの意義に関する検討, 第82回日本臨床外科学会総会, Oct. 2020.
250.	Tetsuya Ikemoto, Kazunori Tokuda, Yu Saitou, Katsuki Miyazaki, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : 再生医療技術による1型糖尿病根治へ向けたシーズの臨床応用に関する検討, 第82回日本臨床外科学会総会, Oct. 2020.
251.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Kazunori Tokuda, Shohei Okikawa, Shoko Yamashita, Katsuki Miyazaki and Mitsuo Shimada : Microbiome, HSCに着目した大建中湯の消化器癌に対する多面的効果の検討, 第82回日本臨床外科学会総会, Oct. 2020.
252.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : Hologramを用いた次世代術中手術支援 -術中Real-time 3D胆管造影を併用した胆道手術-, 第82回日本臨床外科学会総会, Oct. 2020.
253.	Yuji Morine, Mitsuo Shimada, Hiroki Ishibashi, 新井田達雄 and 藤井秀樹 : 膵・胆管合流異常における術式と短期・長期合併症:全国追跡調査から, 第82回日本臨床外科学会総会, Oct. 2020.
254.	Katsuki Miyazaki, Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Kazunori Tokuda, Masato Yoshikawa and Mitsuo Shimada : 膵頭十二指腸切除術(PD)術後合併症回避に向けた腹腔動脈起始部圧迫症候群の周術期管理, 第56回日本腹部救急医学会総会, Oct. 2020.
255.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Katsuki Miyazaki, Mitsuo Shimada and 高露泙 : ソラフェニブ耐性肝細胞癌において，Nrf2は肝細胞性，遊走能，ABC transporterの発現を上昇させる, --- Nrf2 signaling promotes cancer stemness, migration and expression of ABC transporters in sorafenib-resistant HCC ---, 第79回日本癌学会学術集会, Oct. 2020.
256.	Yu Saitou, Tetsuya Ikemoto, Yusuke Arakawa, Satoru Imura, Yuji Morine and Mitsuo Shimada : 3次元培養によるヒト脂肪由来間葉系幹細胞から肝細胞様細胞への効率的分化誘導, 第56回日本肝臓学会総会, Aug. 2020.
257.	Katsuki Miyazaki, Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Kazunori Tokuda, Masato Yoshikawa and Mitsuo Shimada : 肝内胆管癌予後規定因子としてのLymphocyte / CRP ratio (LCR)の意義, 第120回日本外科学会定期学術集会, Aug. 2020.
258.	Masato Yoshikawa, Yuji Morine, Shin-ichiro Yamada, Katsuki Miyazaki, Kazunori Tokuda, Yu Saitou, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : DWI-MRIのADC値を用いた転移性肝癌の予後予測に関する検討, 第120回日本外科学会定期学術集会, Aug. 2020.
259.	Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 膵癌術後予後予測因子としての術前fibrinogen:血小板比の有用性, 第120回日本外科学会定期学術集会, Aug. 2020.
260.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : 切除可能大腸癌限局性肝転移の治療指針, 第120回日本外科学会定期学術集会, Aug. 2020.
261.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda and Masato Yoshikawa : 外科医の視点から開発された皮下脂肪から分離した脂肪由来幹細胞のインスリン産生細胞移植に関する研究, 第120回日本外科学会定期学術集会, Aug. 2020.
262.	Kazunori Tokuda, Tetsuya Ikemoto, 高露萍, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : 肪由来幹細胞(ADSC)から肝細胞様細胞(HLC)への分化誘導における3D培養の有用性, 第120回日本外科学会定期学術集会, Aug. 2020.
263.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : 膵癌切除症例におけるFrailの意義に関する検討, 第120回日本外科学会定期学術集会, Aug. 2020.
264.	Yu Saitou, Mitsuo Shimada, 杉本真樹, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Masato Yoshikawa and Katsuki Miyazaki : Holographyを用いた次世代術中手術支援とICG蛍光法による肝離断navigation, 第120回日本外科学会定期学術集会, Aug. 2020.
265.	Satoru Imura, Katsuki Miyazaki, Masato Yoshikawa, Kazunori Tokuda, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 小型肝癌に対する肝実質温存肝区画切除は妥当である, 第120回日本外科学会定期学術集会, Aug. 2020.
266.	Hiroki Ishibashi, Hiroki Mori, Yuji Morine, Mitsuo Shimada and 藤井秀樹 : 小児先天性胆道拡張症における晩期合併症と長期予後について-重症度分類と全国登録症例の追跡調査による検討-, 第120回日本外科学会定期学術集会, Aug. 2020.
267.	Katsuki Miyazaki, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Kazunori Tokuda, Masato Yoshikawa and Mitsuo Shimada : 肝内胆管癌予後規定因子としてのLymphocyte/CRP ratio(LCR)の意義, 第113回日本消化器病学会四国支部例会, Jun. 2020.
268.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shin-ichiro Yamada, Katsuki Miyazaki and Mitsuo Shimada : DAA治療後SVR症例は発癌Potentialが高く進行病期に関与する, 第113回日本消化器病学会四国支部例会, Jun. 2020.
269.	Kazunori Tokuda, Tetsuya Ikemoto, Mitsuo Shimada, Yu Saitou, Masato Yoshikawa, Shin-ichiro Yamada, Yusuke Arakawa, Satoru Imura and Yuji Morine : 亜鉛イオンに着目したADSCから製造したInsulin-producing cell 成熟度に関する検討, 第19回日本再生医療学会総会, May 2020.
270.	Yu Saitou, Tetsuya Ikemoto, Yusuke Arakawa, Katsuki Miyazaki, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : GSK3 inhibitorsを用いた脂肪由来間葉系幹細胞から肝細胞様細胞への3次元分化誘導, 第19回日本再生医療学会総会, May 2020.
271.	Tetsuya Ikemoto, Mitsuo Shimada, Kazunori Tokuda, Yu Saitou, Masato Yoshikawa, Katsuki Miyazaki, Shin-ichiro Yamada, Yusuke Arakawa, Satoru Imura and Yuji Morine : T1DM患者から採取された脂肪組織から分離したADSCから製造したInsulin-producing cellに関する検討, 第19回日本再生医療学会総会, May 2020.
272.	Katsuki Miyazaki, Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Kazunori Tokuda, Masato Yoshikawa and Mitsuo Shimada : 肝内胆管癌予後規定因子としてのLymphocyte / CRP ratio (LCR)の意義, 第53回制癌剤適応研究会, Feb. 2020.
273.	Masato Yoshikawa, Shin-ichiro Yamada, Yuji Morine, Katsuki Miyazaki, Kazunori Tokuda, Yu Saitou, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 転移性肝癌におけるDWI-MRIのADC値を用いた予後予測に関する検討, 第53回制癌剤適応研究会, Feb. 2020.
274.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : 腫瘍関連マクロファージを介した肝胆膵癌の悪性度獲得に関する検討, 第53回制癌剤適応研究会, Feb. 2020.
275.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki and Mitsuo Shimada : NBNC肝細胞癌の発癌と進展の分子標的からみた治療戦略, 第53回制癌剤適応研究会, Feb. 2020.
276.	Masato Yoshikawa, Tetsuya Ikemoto, Toshiaki Yoshimoto, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Satoru Imura, Yuji Morine and Mitsuo Shimada : 膵切除周術期における人工膵臓を用いた血糖管理の有用性, 第260回徳島医学学会学術集会, Feb. 2020.
277.	Toshiaki Yoshimoto, Yukako Takehara, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Tomohiko Miyatani, Kouzou Yoshikawa, Yuji Morine and Mitsuo Shimada : LED光による新たな癌制御法の開発, 第260回徳島医学会学術集会, Feb. 2020.
278.	Yu Saitou, Tetsu Tomonari, Shin-ichiro Yamada, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Tetsuji Takayama and Mitsuo Shimada : 分子標的治療薬によりConversion Hepatectomyを施行し得た進行肝細胞癌の3例, 第21回日本肝がん分子標的治療研究会, Jan. 2020.
279.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto and Yu Saitou : MRIを利用した肝切除限界予測と，腫瘍悪性度評価に関する検討, 第43回日本肝臓学会西部会, Dec. 2019.
280.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Mitsuo Shimada : 肝細胞癌に対する肝切除術におけるFrailtyの意義に関する検討, JDDW2019, Nov. 2019.
281.	Masaaki Nishi, Mitsuo Shimada, 河野透, Yuji Morine, 勝野秀稔, 前田耕太郎, 肥田圭介, 森田智視, 渡邊昌彦, 草野満夫, 坂本純一, 佐野重豊, 前原喜彦, 兼松隆之 and 北島政樹 : 大建中湯の効果と投与条件の探索的研究-3つの臨床試験の統合解析-, 第81回日本臨床外科学会総会, Nov. 2019.
282.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara, Yuji Morine and Mitsuo Shimada : 光受容体Opsin3をターゲットとした青色LEDの大腸癌抑制効果, 第81回日本臨床外科学会総会, Nov. 2019.
283.	Masato Yoshikawa, Tetsuya Ikemoto, Toshiaki Yoshimoto, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Satoru Imura, Yuji Morine and Mitsuo Shimada : 膵切除周術期における人工膵臓を用いた血糖管理の有用性, 第81回日本臨床外科学会総会, Nov. 2019.
284.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shin-ichiro Yamada, Masato Yoshikawa and 杉本真樹 : ホログラムとウェアラブル近赤外蛍光法による肝切除手術支援, 第81回日本臨床外科学会総会, Nov. 2019.
285.	Tetsuya Ikemoto, Kazunori Tokuda, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Yusuke Arakawa, Satoru Imura, Yuji Morine and Mitsuo Shimada : insulin-producing cell移植の細胞移植治療への臨床応用に向けた研究, 第81回日本臨床外科学会総会, Nov. 2019.
286.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : 肝細胞癌に対する肝切除術におけるFrailtyの意義に関する検討, 第81回日本臨床外科学会総会, Nov. 2019.
287.	Yuji Morine, Shin-ichiro Yamada, Tetsuya Ikemoto, Yu Saitou, Yusuke Arakawa, Masato Yoshikawa, Satoru Imura and Mitsuo Shimada : 腸管Microbiome解析を加えた大建中湯の消化器疾患に対する多面的効果の検討, 第81回日本臨床外科学会総会, Nov. 2019.
288.	Hiroki Mori, Yuji Morine, Noriko Yokota, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常におけるDNA切断修復応答を介した胆道癌発癌機構に関する検討, 第30回日本消化器癌発生学会総会, Nov. 2019.
289.	Yuji Morine : 原発性肝癌の分子生物学的アプローチによる腫瘍悪性度評価, 第30回日本消化器癌発生学会総会, Nov. 2019.
290.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yukako Takehara, Yuji Morine and Mitsuo Shimada : 光受容体Opn3を介した青色LEDの大腸癌抑制効果, 第57回日本癌治療学会学術集会, Oct. 2019.
291.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto, Katsuki Miyazaki and Mitsuo Shimada : 肝細胞癌に対する肝切除術におけるFrailtyの意義に関する検討, 第57回日本癌治療学会学術集会, Oct. 2019.
292.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Mitsuo Shimada : 臨床病理学的特徴と腫瘍悪性度解析からみたNBNC肝細胞癌の治療戦略, 第57回日本癌治療学会学術集会, Oct. 2019.
293.	Masato Yoshikawa, Yu Saitou, 高露萍, Tetsuya Ikemoto, Yusuke Arakawa, Katsuki Miyazaki, Satoru Imura, Yuji Morine and Mitsuo Shimada : GSK3 inhibitorsを用いた脂肪由来間葉系幹細胞から肝細胞様細胞への分化誘導, 第55回日本移植学会総会, Oct. 2019.
294.	Yu Saitou, Satoru Imura, Katsuki Miyazaki, Masato Yoshikawa, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 脳死肝移植ドナー不足解消にむけての取り組み- 医療系学生に対するDonor Action(命の授業)の必要性 –, 第55回日本移植学会総会, Oct. 2019.
295.	Yusuke Arakawa, Yu Saitou, 高露萍, Tetsuya Ikemoto, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脂肪由来幹細胞からインスリン産生細胞への分化誘導における赤色LEDの有用性に関する研究, 第55回日本移植学会総会, Oct. 2019.
296.	Tetsuya Ikemoto, Yu Saitou, Satoru Imura, Yuji Morine, Kazunori Tokuda, Shin-ichiro Yamada, Masato Yoshikawa and Mitsuo Shimada : 再生医療技術を用いたinsulin-producing cell移植の臨床応用に向けた研究, 第55回日本移植学会総会, Oct. 2019.
297.	Yukako Takehara, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Shoko Iwahashi, Koichi Tsuneyama and Mitsuo Shimada : SSTR2, Bcl2発現からみた肝内胆管癌の組織発生学的分類, 第55回日本胆道学会学術集会, Oct. 2019.
298.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto and Mitsuo Shimada : MRI拡散強調画像から見た肝内胆管癌の腫瘍悪性度に関する検討, 第55回日本胆道学会学術集会, Oct. 2019.
299.	Yuji Morine, Mitsuo Shimada and 藤井秀樹 : 膵・胆管合流異常における術式と短期・長期合併症と胆道発癌ポテンシャルに関する検討, 第55回日本胆道学会学術集会, Oct. 2019.
300.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : Prognostic prediction of mass-forming intrahepatic cholangiocarcinoma from ADC value of DWI-MRI, JSH International Liver Conference, Oct. 2019.
301.	Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝癌細胞におけるNrf2に着目した腫瘍関連マクロファージ活性化の検討, 第78回日本癌学会学術総会, Sep. 2019.
302.	Hiroki Mori, Yuji Morine, Noriko Yokota, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常の胆道癌発癌機構にDNA損傷修復経路が関与する, 第42回日本膵・胆管合流異常研究会, Sep. 2019.
303.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shin-ichiro Yamada, Masato Yoshikawa, Katsuki Miyazaki, 杉本真樹 and Mitsuo Shimada : Hologramを用いた次世代術前術中手術支援とICG蛍光法による肝離断navigation, 第14回肝癌治療ナビゲーション研究会, Sep. 2019.
304.	Masato Yoshikawa, Shoko Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Katsuki Miyazaki, Koichi Tsuneyama and Mitsuo Shimada : 卵巣様間質を伴う非粘液性嚢胞腺腫の二例, 第71回日本消化器画像診断研究会, Sep. 2019.
305.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Masato Yoshikawa and Katsuki Miyazaki : MRI拡散強調画像から見た肝内胆管癌の腫瘍悪性度に関する検討, 第71回日本消化器画像診断研究会, Sep. 2019.
306.	Yu Saitou, Satoru Imura, Katsuki Miyazaki, Masato Yoshikawa, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 脳死肝移植ドナー不足解消にむけての取り組み- 医療系学生に対するDonor Action(命の授業)の必要性-, 第37回日本肝移植学会, Jul. 2019.
307.	Yusuke Arakawa, Yu Saitou, 高露萍, Tetsuya Ikemoto, Katsuki Miyazaki, Masato Yoshikawa, Satoru Imura, Yuji Morine and Mitsuo Shimada : GSK3 inhibitorsを用いた脂肪由来間葉系幹細胞から肝細胞様細胞への分化誘導, 第37回日本肝移植学会, Jul. 2019.
308.	Shoko Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : SSTR2・Bcl2発現による肝内胆管癌組織発生学的特徴に関する検討, 第74回日本消化器外科学会総会, Jul. 2019.
309.	Shuichi Iwahashi, Mitsuo Shimada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yu Saitou and Shin-ichiro Yamada : 長期成績に着目した膵全摘症例の検討 -術後QOL評価に着目して-, 第74回日本消化器外科学会総会, Jul. 2019.
310.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝細胞癌に対する系統的肝区画切除は妥当である, 第74回日本消化器外科学会総会, Jul. 2019.
311.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi and Yu Saitou : 肝細胞癌の肝切除術におけるFrailtyの意義に関する検討, 第74回日本消化器外科学会総会, Jul. 2019.
312.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : ホログラム術中胆道造影とウェアラブル近赤外蛍光法による肝切除手術支援, 第74回日本消化器外科学会総会, Jul. 2019.
313.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 肝内胆管癌の治療戦略:至適切除範囲と補助療法の効果, 第74回日本消化器外科学会総会, Jul. 2019.
314.	Tetsuya Ikemoto, Mitsuo Shimada, Masao Fuketa, Shinsuke Katoh, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : The utilization of `Big Data' in gastroenterological surgery, 第74回日本消化器外科学会総会, Jul. 2019.
315.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : ホログラムとウェアラブル近赤外蛍光法による肝切除手術支援, 第55回日本肝癌研究会, Jul. 2019.
316.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi and Yu Saitou : EOB-MRIを用いた新たな肝切除基準の有用性, 第55回日本肝癌研究会, Jul. 2019.
317.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and Mitsuo Shimada : 肝内胆管癌の治療戦略:至適切除範囲と補助療法の効果, 第55回日本肝癌研究会, Jul. 2019.
318.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝癌に対する腹腔鏡肝切除の現状と今後の適応拡大, 第55回日本肝癌研究会, Jul. 2019.
319.	Masato Yoshikawa, Yuuma Wada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Shoko Iwahashi and Mitsuo Shimada : 脂肪由来幹細胞からのインスリン産生細胞分化誘導に関する研究, 第26回外科侵襲とサイトカイン研究会, Jul. 2019.
320.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto and Mitsuo Shimada : DWI-MRIのADC値を用いたSorafenibの効果予測に関する検討, 第20回日本肝がん分子標的治療研究会, Jun. 2019.
321.	Tetsuya Ikemoto, Mitsuo Shimada, Masao Fuketa, Shinsuke Katoh, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : 医療安全に関するAI活用と新たなアラートシステム構築, 第44回日本外科系連合学会学術集会, Jun. 2019.
322.	Katsuki Miyazaki, Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada and Mitsuo Shimada : A case of preoperative nutritional and exercise intervention in HCC patient with alcoholic liver cirrhosis, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
323.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : Intraoperative support using holographic cholangiography and near-infrared fluorescence imaging, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
324.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Shin-ichiro Yamada : The effect of hepatic stellate cells on hepatocellular carcinoma progression, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
325.	Yuji Morine, Shin-ichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Standardization of surgical technique in laparoscopic distal pancreatectomy, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
326.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada, Toshiaki Yoshimoto, Shogo Oota and Mitsuo Shimada : Prognostic prediction of apparent diffusion coefficient obtained by diffusion-weighted MRI in mass-forming intrahepatic cholangiocarcinoma, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
327.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada and Mitsuo Shimada : Goal for board certified HBP surgeon, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
328.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : Our scientific approaches and investigation for Japanese Kampo Medicine in hepato-biliary-pancreatic diseases; especially TU-100 and TJ-48, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
329.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Evaluation of liver function using signal intensity of EOB-MRI for safe hepatectomy, 第31回日本肝胆膵外科学会学術集会, Jun. 2019.
330.	Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝癌に対する腹腔鏡肝切除の現状と今後の適応拡大, 第55回日本肝臓学会総会, May 2019.
331.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : ホログラムとウェアラブル近赤外蛍光法による肝切除手術支援, 第73回手術手技研究会, May 2019.
332.	Hiroki Mori, Yuji Morine, Noriko Yokota, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常におけるDNA損傷修復応答を介した胆道癌発癌機構に関する検討, 第56回日本小児外科学会学術集会, May 2019.
333.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada, Toshiaki Yoshimoto, 西山光恵 and 五十嵐康 : 大建中湯(TU-100)のNASH発癌抑制効果に関する検討, 第105回日本消化器病学会総会, May 2019.
334.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada and Mitsuo Shimada : Usefulness of "one-stop shop" liver surgery simulation using EOB-MRI., ILLS2019, May 2019.
335.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi and Yu Saitou : Standardization of surgical technique in laparoscopic left hemihepatectomy., ILLS2019, May 2019.
336.	Hiroki Mori, Yuji Morine, Noriko Yokota, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常におけるDNA損傷修復経路を介した胆道癌発癌機構に関する検討, 第119回日本外科学会定期学術集会, Apr. 2019.
337.	Chie Takasu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Yuuma Wada, Toshiaki Yoshimoto, Shogo Oota and Mitsuo Shimada : 大腸癌肝転移における免疫逃避機構は原発巣と異なる可能性がある, 第119回日本外科学会定期学術集会, Apr. 2019.
338.	Katsuki Miyazaki, Shoko Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : 卵巣様間質を伴う非粘液性嚢胞腺腫の2例, 第119回日本外科学会定期学術集会, Apr. 2019.
339.	Shoko Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Koichi Tsuneyama and Mitsuo Shimada : SSTR2発現からみた肝内胆管癌の組織発生学的分類, 第119回日本外科学会定期学術集会, Apr. 2019.
340.	Shogo Oota, Mitsuo Shimada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Yuuma Wada, Toshiaki Yoshimoto and Shoko Iwahashi : Insulin-producing cell(IPC)分化成熟と亜鉛イオン濃度相関に関する研究, 第119回日本外科学会定期学術集会, Apr. 2019.
341.	Toshiaki Yoshimoto, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Yuuma Wada, Shogo Oota, Shoko Iwahashi and Mitsuo Shimada : 青色LED光のOpn3を介した大腸癌抑制効果 (第2報), 第119回日本外科学会定期学術集会, Apr. 2019.
342.	Yuuma Wada, Yuji Morine, Yu Saitou, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, Toshiaki Yoshimoto, Shogo Oota and Mitsuo Shimada : 癌微小環境における大建中湯の肝星細胞活性化制御・癌細胞オートファジーを介した癌細胞増殖抑制効果, 第119回日本外科学会定期学術集会, Apr. 2019.
343.	Tetsuya Ikemoto, Mitsuo Shimada, Masao Fuketa, Shinsuke Katoh, Masaaki Nishi, Satoru Imura and Yuji Morine : 患者に信頼される病院を目指す戦略~AIを用いたインシデントレポート管理の未来, 第119回日本外科学会定期学術集会, Apr. 2019.
344.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : ホログラム術中胆道造影とウェアラブル近赤外蛍光法による肝切除手術支援, 第119回日本外科学会定期学術集会, Apr. 2019.
345.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Toshiaki Yoshimoto, Shoko Iwahashi, 西山光恵 and 五十嵐康 : 大建中湯(TU-100)のNASH発癌抑制効果に関する検討, 第119回日本外科学会定期学術集会, Apr. 2019.
346.	Shuichi Iwahashi, Tetsuya Ikemoto, Yuuma Wada, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Toshiaki Yoshimoto, Shogo Oota and Mitsuo Shimada : 臨床応用に向けたインスリン産生細胞分化誘導に関する研究, 第119回日本外科学会定期学術集会, Apr. 2019.
347.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and Jun Higashijima : 大腸癌肝転移に対する肝切除を中心とした治療戦略 - Upfront肝切除適応基準と切除不能例に対するConversion surgery-, 第119回日本外科学会定期学術集会, Apr. 2019.
348.	Shogo Oota, Mitsuo Shimada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Yuuma Wada, Toshiaki Yoshimoto and Shoko Iwahashi : Insulin-producing cell(IPC)分化成熟と亜鉛イオン濃度相関に関する研究, 第18回日本再生医療学会総会, Mar. 2019.
349.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Yuji Morine and Mitsuo Shimada : 大腸癌に対する青色LED光の光受容体を介した抗腫瘍効果, 第52回制癌剤適応研究会, Mar. 2019.
350.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Toshiaki Yoshimoto : 肝胆膵領域癌におけるNrf2に着目した腫瘍関連マクロファージ活性化の検討, 第52回制癌剤適応研究会, Mar. 2019.
351.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi and Yu Saitou : 当科における腹腔鏡下膵体尾部切除術の定型化と成績に関する検討, 第33回四国内視鏡外科研究会, Feb. 2019.
352.	Toshiaki Yoshimoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : Lenvatinib投与中に呼吸不全を併発し急激な悪化の転機をたどった肝細胞癌多発肺転移の1例, 第2回徳島外科医会, Feb. 2019.
353.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi and Yu Saitou : 当科における腹腔鏡下膵体尾部切除術の定型化と成績に関する検討, 第2回徳島外科医会, Feb. 2019.
354.	Yuuma Wada, Shuichi Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, 馮睿 and Mitsuo Shimada : 腫瘍関連マクロファージに着目した肝癌細胞悪性度上昇の検討, 第19回日本肝がん分子標的治療研究会, Jan. 2019.
355.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Yuuma Wada : MRI拡散強調画像から見た肝内胆管癌の腫瘍悪性度に関する検討, 第19回日本肝がん分子標的治療研究会, Jan. 2019.
356.	Yuuma Wada, Tetsuya Ikemoto, Shuichi Iwahashi, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Masaaki Nishi, Satoru Imura and Mitsuo Shimada : 膵島保護におけるNrf2を介した Epigallocatechin-3-gallate (EGCG)の効果, 第48回創傷治癒学会, Nov. 2018.
357.	Hiroki Mori, Yuji Morine, Noriko Yokota, Hiroki Ishibashi, Kazuaki Mawatari, Akira Takahashi and Mitsuo Shimada : 膵・胆管合流異常における発がんメカニズムに関する検討, 第80回日本臨床外科学会総会, Nov. 2018.
358.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : 肝切除における術中手術支援のブレイクスル- -Virtual Reality & 肝離断Navigation –, 第80回日本臨床外科学会総会, Nov. 2018.
359.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Evaluation of liver function for safe and radical hepatectomy in elderly patients (高齢者肝切除の安全性・根治性向上のための肝機能評価), 第80回日本臨床外科学会総会, Nov. 2018.
360.	Yuji Morine : 腸管Microbiome解析からみた大建中湯の消化器疾患に対する作用検証, 第80回日本臨床外科学会総会, Nov. 2018.
361.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Toshiaki Yoshimoto : 大腸癌切除不能両葉多発肝転移におけるConversion後予後に関する検討-FOLFOXIRI療法の有用性-, 第80回日本臨床外科学会総会, Nov. 2018.
362.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Toshiaki Yoshimoto : 当科における腹腔鏡下膵体尾部切除術の定型化と成績に関する検討, 第10回膵臓内視鏡外科研究会・第12回肝臓内視鏡外科研究会, Nov. 2018.
363.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Rui Feng, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Toshiaki Yoshimoto : 肝癌細胞におけるNrf2に着目した腫瘍関連マクロファージ活性化の検討, 第29回日本消化器癌発生学会総会, Nov. 2018.
364.	Hideya Kashihara, Toshiaki Yoshimoto, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Tomohiko Miyatani, Jun Higashijima, Kouzou Yoshikawa, Yuji Morine and Mitsuo Shimada : 大腸癌に対する青色LED光の効果と光受容体の関与についての研究, 第29回日本消化器癌発生学会総会, Nov. 2018.
365.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 肝癌細胞におけるNrf2に着目した腫瘍関連マクロファージ活性化の検討, JDDW2018, Nov. 2018.
366.	Yuji Morine, Satoru Imura and Mitsuo Shimada : Treatment strategy for unresectable colorectal liver metastases: Clinical impact of FOLFOXIRI regimen, JDDW2018, Nov. 2018.
367.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Shin-ichiro Yamada : 肝癌細胞におけるNrf2に着目した腫瘍関連マクロファージ活性化の検討, 第56回日本癌治療学会学術集会, Oct. 2018.
368.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada, Toshiaki Yoshimoto and Shogo Oota : MRI拡散強調画像から見た肝内胆管癌の腫瘍悪性度に関する検討, 第56回日本癌治療学会学術集会, Oct. 2018.
369.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Shin-ichiro Yamada, Shuichi Iwahashi, Tetsuya Ikemoto and Yuji Morine : 脳死肝移植ドナー不足解消にむけての取り組み-医療系学生に対するDonor Action(命の授業)の必要性-, 第54回日本移植学会総会, Oct. 2018.
370.	Yuuma Wada, Tetsuya Ikemoto, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Satoru Imura and Mitsuo Shimada : Nrf2経路によるEGCGの膵島保護効果, 第54回日本移植学会総会, Oct. 2018.
371.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : 臨床応用を目指した間葉系幹細胞から創生されるインスリン産生細胞による糖尿病の治療法確立に関する研究, 第54回日本移植学会総会, Oct. 2018.
372.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Shin-ichiro Yamada, 杉本真樹 and Mitsuo Shimada : Virtual Realityを用いた肝切除における術中手術支援, 第13回肝癌治療シミュレーション研究会, Sep. 2018.
373.	Yu Saitou, Hiroki Mori, Yuji Morine, Keigo Yada, Hiroki Ishibashi, 馬渡一論, Akira Takahashi and Mitsuo Shimada : メタボローム解析を用いた膵・胆管合流異常の胆汁中発癌物質の同定, 第54回日本胆道学会学術集会, Sep. 2018.
374.	Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Nrf2ActivationDriveMacrophagesPolarizationAndCancerCellEpithelial-Mesenchymal Transition During Interaction, 第77回日本癌学会学術集会, Sep. 2018.
375.	Tetsuya Ikemoto, Mitsuo Shimada, Shogo Oota, Yuuma Wada, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : 膵癌患者における末梢血Tr1細胞が反映するPDL-1発現の意義に関する検討, 第77回日本癌学会学術集会, Sep. 2018.
376.	Shin-ichiro Yamada, Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : 造影効果から見た肝内胆管癌の腫瘍悪性度に関する検討, 第54回日本胆道学会学術集会, Sep. 2018.
377.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Toshiaki Yoshimoto, Yuuma Wada and Shogo Oota : 長期予後に着目した膵全摘症例の検討-近年の化学療法の発展に伴う治療選択肢として-, 第27回消化器疾患病態治療研究会, Sep. 2018.
378.	Yuji Morine, Mitsuo Shimada, Hiroki Ishibashi, 窪田正幸 and 安藤久實 : 膵・胆管合流異常症全国集計追跡調査2015・2017-特に非癌合併症例における短期・長期合併症について-, 第41回日本膵・胆管合流異常研究会, Sep. 2018.
379.	Toshiaki Yoshimoto, Mitsuo Shimada, Shuichi Iwahashi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Shin-ichiro Yamada : Nrf2に着目した肝癌細胞における腫瘍関連マクロファージ活性化の検討, 第18回日本肝がん分子標的治療研究会, Jul. 2018.
380.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : EOB-MRIは肝予備能を加味した術前simulationとして有用である, 第73回日本消化器外科学会総会, Jul. 2018.
381.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, 杉本真樹 and Mitsuo Shimada : 肝切除における解剖把握のためのVirtual Reality(VR)によるSimulationと術中手術支援, 第73回日本消化器外科学会総会, Jul. 2018.
382.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Yuuma Wada, Hiroki Teraoku and Shogo Oota : NCDデータからみた地方における消化器外科手術の特色と安全性評価に関する検討, 第73回日本消化器外科学会総会, Jul. 2018.
383.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Hiroki Teraoku : 肝内胆管癌に対する総合的治療戦略, 第73回日本消化器外科学会総会, Jul. 2018.
384.	Satoru Imura, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 手技定型化とstepwise training による安全な腹腔鏡下肝左葉切除, 第73回日本消化器外科学会総会, Jul. 2018.
385.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : CT動脈相の造影効果から見た肝内胆管癌の腫瘍悪性度に関する検討, 第73回日本消化器外科学会総会, Jul. 2018.
386.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Hiroki Teraoku : 長期予後に着目した膵全摘症例の検討-近年の化学療法の発展に伴う治療選択肢として-, 第49回日本膵臓学会大会, Jun. 2018.
387.	Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Koichi Tsuneyama and Mitsuo Shimada : 症例, 第54回日本肝癌研究会, Jun. 2018.
388.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 肝星細胞はIL-6を介して肝癌細胞の悪性度増強・転移促進に寄与する, 第54回日本肝癌研究会, Jun. 2018.
389.	Yu Saitou, Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi and Jun Higashijima : 同時性大腸癌肝転移に対する治療戦略, 第54回日本肝癌研究会, Jun. 2018.
390.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku and Mitsuo Shimada : 肝内胆管癌に対する総合的治療戦略, 第54回日本肝癌研究会, Jun. 2018.
391.	Satoru Imura, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝癌に対する腹腔鏡肝切除の現状と今後の適応拡大, 第54回日本肝癌研究会, Jun. 2018.
392.	Shoko Iwahashi, Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Mitsuo Shimada and Koichi Tsuneyama : 自然退縮を認めたInflammatory hepatocellular adenomaの一例, 第109回日本消化器病学会四国支部例会, Jun. 2018.
393.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : 集学的治療としての膵全摘症例の検討, 第109回日本消化器病学会四国支部例会, Jun. 2018.
394.	Tetsuya Ikemoto, Mitsuo Shimada, Shinsuke Katoh, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : 消化器・移植外科から発信する手術室の医療安全と効率化の両立, 第43回日本外科系連合学会学術集会, Jun. 2018.
395.	Shuichi Iwahashi, Yuji Morine and Mitsuo Shimada : 大腸癌切除不能両葉多発肝転移に対する治療戦略―FOLFOXIRI療法のよるConversionの可能性―, 第54回日本肝臓学会総会, Jun. 2018.
396.	Yuji Morine, Mitsuo Shimada and Satoru Imura : 肝内胆管癌に対する総合的治療戦略, 第54回日本肝臓学会総会, Jun. 2018.
397.	Yu Saitou, Satoru Imura, Hiroki Teraoku, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, 杉本真樹 and Mitsuo Shimada : Simulation and intraoperative support with virtual reality (VR)for anatomical grasp in hepatectomy., 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
398.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : Usefulness of 'one-stop shop' liver surgery simulation including estimation of total and regional liver functional reserve using EOB-MRI, 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
399.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Hiroki Teraoku : Investigations for total pancreatectomy-focused on short-and long-term outcome-, 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
400.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku, Jun Higashijima, Chie Takasu and Mitsuo Shimada : Treatment guidance in resectable colorectal liver metastasis., 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
401.	Satoru Imura, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Our educational system for safe and reliable hepatectomy., 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
402.	Hiroki Teraoku, Tetsuya Ikemoto, Shogo Oota, Yuuma Wada, Yu Saitou, Shuichi Iwahashi, Satoru Imura, Yuji Morine and Mitsuo Shimada : Preoperative care and surgical management for elderly and/or high-risk patients, 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
403.	Yuuma Wada, Yuji Morine, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, shogo ohta and Mitsuo Shimada : Significance of hypoxia inducible factor-1 expression in liver metastasis of colorectal cancer., 第30回日本肝胆膵外科学会学術集会, Jun. 2018.
404.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 末梢血Tr1比率はIPMNの悪性度評価に有用である, 第27回日本癌病態治療研究会, May 2018.
405.	Hiroki Mori, Yuji Morine, Keigo Yada, Hiroki Ishibashi, Kazuaki Mawatari, Akira Takahashi and Mitsuo Shimada : メタボローム解析を用いた膵・胆管合流異常における胆汁発癌物質の検討, 第55回日本小児外科学会学術集会, May 2018.
406.	Hiroki Ishibashi, Hiroki Mori, Keigo Yada, Noriko Yokota, Yuji Morine, Mitsuo Shimada and 安藤久實 : 先天性胆道拡張症の全国集計からみた小児から成人移行への問題点―追跡調査と重症度分類での検討―, 第55回日本小児外科学会学術集会, May 2018.
407.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 発光ダイオード(LED)の波長強度可変装置による肝細胞保護に関する研究, 第36回日本肝移植研究会, May 2018.
408.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Hiroki Teraoku, Shuichi Iwahashi, Tetsuya Ikemoto and Yuji Morine : 医療系学生に対するDonor Actionの必要性- 移植医療理解・意思表示率向上にむけての取り組み –, 第36回日本肝移植研究会, May 2018.
409.	Jun Higashijima, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Kouzou Yoshikawa, Hiroki Mori, Takuya Tokunaga, Masaaki Nishi, Shuichi Iwahashi, Yu Saitou, Hideya Kashihara, Chie Takasu and Keigo Yada : Academic surgeon 育成のための新たな研修への取り組み―大学病院と市中病院の新たな連携―, 第36回臨床研修研究会, Apr. 2018.
410.	Hiroki Mori, Yuji Morine, Keigo Yada, Hiroki Ishibashi, Kazuaki Mawatari, Akira Takahashi and Mitsuo Shimada : メタボローム解析を用いた膵・胆管合流異常の胆汁中発癌物質の同定, 第118回日本外科学会定期学術集会, Apr. 2018.
411.	宮崎克己, Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Koichi Tsuneyama and Mitsuo Shimada : 自然退縮を認めたInflammatory hepatocellular adenomaの一例, 第118回日本外科学会定期学術集会, Apr. 2018.
412.	Yu Saitou, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, Satoru Imura, Yuji Morine and Mitsuo Shimada : Epigallocatechin gallate(EGCG)による脂肪由来間葉系幹細胞(ADSC)からInsulin producing cell(IPC)への効率的な分化誘導に関する研究, 第118回日本外科学会定期学術集会, Apr. 2018.
413.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, 杉本真樹 and Mitsuo Shimada : 肝予備能を加味したOne Stop Shop SimulationとMixed realityによる新たなNavigation, 第118回日本外科学会定期学術集会, Apr. 2018.
414.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku and Jun Higashijima : 同時性大腸癌肝転移に対する治療戦略, 第118回日本外科学会定期学術集会, Apr. 2018.
415.	Satoru Imura, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Lifting methodを駆使した安全・確実な開腹肝切除, 第118回日本外科学会定期学術集会, Apr. 2018.
416.	Shogo Oota, Mitsuo Shimada, Masaaki Nishi, Takuya Tokunaga, Jun Higashijima, Daichi Ishikawa, Kouzou Yoshikawa, Chie Takasu, Hideya Kashihara and Yuji Morine : ICG蛍光システムを用いたTaTMEにおける尿道損傷回避に向けた取り組み, 第118回日本外科学会定期学術集会, Apr. 2018.
417.	Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku, Shogo Oota and Mitsuo Shimada : 大腸癌肝転移におけるHypoxia Inducible Factor-1発現の意義 -肝転移巣・原発巣における腫瘍悪性度評価-, 第118回日本外科学会定期学術集会, Apr. 2018.
418.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : 肝内胆管癌の造影効果による腫瘍悪性度評価の検討, 第118回日本外科学会定期学術集会, Apr. 2018.
419.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Yuuma Wada and Hiroki Teraoku : Epigallocatechin-3-gallateはNrf2を介して膵島保護作用を有する, 第118回日本外科学会定期学術集会, Apr. 2018.
420.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Yuuma Wada, Hiroki Teraoku and Shogo Oota : 臨床応用を目指した間葉系幹細胞から創生されるインスリン産生細胞による糖尿病の治療法確立に関する研, 第118回日本外科学会定期学術集会, Apr. 2018.
421.	Hiroki Teraoku, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : Sorafenib投与症例におけるHCC長期生存例の検討, 第51回制癌剤適応研究会, Mar. 2018.
422.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 肝星細胞はIL-9を介して肝癌細胞増強・転移促進に寄与する, 第51回制癌剤適応研究会, Mar. 2018.
423.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 肝星細胞はIL-6を介して肝癌細胞増強・転移促進に寄与する, 第17回日本肝がん分子標的治療研究会, Jan. 2018.
424.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 当科における腹腔鏡(補助)下膵体尾部切除術の検討, 第9回膵臓内視鏡外科研究会, Dec. 2017.
425.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku, 杉本真樹 and Mitsuo Shimada : 若手医師による術前術中3Dsimulation画像を用いた腹腔鏡下手術の定型化, 第11回肝臓内視鏡外科研究会, Dec. 2017.
426.	Satoru Imura, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 手技定型化による安全な腹腔鏡下肝左葉切除, 第11回肝臓内視鏡外科研究会, Dec. 2017.
427.	Yuuma Wada, Tetsuya Ikemoto, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku, Shogo Oota, Satoru Imura and Mitsuo Shimada : Nef2-Keap1経路の膵島保護作用におけるEpigallocatechin-3-gallate(EGCG)の役割, 第47回日本創傷治癒学会, Nov. 2017.
428.	Shoko Iwahashi, Tetsuya Ikemoto, Yu Saitou, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Hiroki Teraoku and Mitsuo Shimada : 併存疾患多数のStageⅣa膵体部癌に対し集学的補助で化学療法jを導入し長期生存を得た一例, 第79回日本臨床外科学会総会, Nov. 2017.
429.	Shogo Oota, Yuuma Wada, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 初回切除後再発膵癌に対する再切除の有用性, 第79回日本臨床外科学会総会, Nov. 2017.
430.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku and Shogo Oota : 超高齢者に対する肝切除の妥当性に関する検討 -85歳以上の超高齢者にも肝切除は安全に施行可能である, 第79回日本臨床外科学会総会, Nov. 2017.
431.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : Modified de-rotation法による完全動脈先行処理を用いた膵頭十二指腸切除術, 第79回日本臨床外科学会総会, Nov. 2017.
432.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Hiroki Teraoku, Chie Takasu and Jun Higashijima : 大腸癌切除不能両葉多発肝転移に対するFOLFOXIRI療法の有用性, 第79回日本臨床外科学会総会, Nov. 2017.
433.	Hiroki Mori, Yuji Morine, Keigo Yada, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常における胆汁発癌物質のメタボローム解析, 第28回日本消化器癌発生学会総会, Nov. 2017.
434.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuuma Wada and Shogo Oota : One stop shopを目指したEOB-MRIによる部分切除術肝機能評価, 第26回日本コンピュータ外科学会大会, Oct. 2017.
435.	Yuuma Wada, Yuji Morine, Kouzou Yoshikawa, Jun Higashijima, Masaaki Nishi, Shuichi Iwahashi, Hideya Kashihara, Chie Takasu, Yu Saitou, Daichi Ishikawa, Hiroki Teraoku, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 青色LED光は光受容体(opsin3)を介し癌細胞増殖を抑制する, 第55回日本癌治療学会学術集会, Oct. 2017.
436.	Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Hiroki Teraoku and Mitsuo Shimada : 肝内胆管癌における局在・浸潤形式別悪性度, 第55回日本癌治療学会学術集会, Oct. 2017.
437.	Shuichi Iwahashi, AHMAD AMMAR GHAIBEH, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 人工知能を用いた肝細胞癌再発予測因子の検討, 第55回日本癌治療学会学術集会, Oct. 2017.
438.	Yuji Morine, Mitsuo Shimada and Satoru Imura : NBNC肝細胞癌における臨床病理学的・分子生物学的特徴の解析, JDDW 2017, Oct. 2017.
439.	Yu Saitou, Satoru Imura, Yuji Morine, Shogo Oota, Hiroki Teraoku, Shuichi Iwahashi, Tetsuya Ikemoto and Mitsuo Shimada : 肝切除におけるVirtual Reality(VR) 画像を駆使した胆管解剖把握のための術中Navigation System, 第12回肝癌治療シミュレーション研究会, Sep. 2017.
440.	Tetsuya Ikemoto, Mitsuo Shimada, Daichi Ishikawa, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : IL driven IL-10 Tr1細胞による細胞レベルのRO/R1手術達成評価に関する検討, 第76回日本癌学会学術総会, Sep. 2017.
441.	Hiroki Teraoku, Tetsuya Ikemoto, Yuuma Wada, Shogo Oota, Yu Saitou, Shuichi Iwahashi, Satoru Imura, Yuji Morine, Mitsuo Shimada and Koichi Tsuneyama : 単純性嚢胞との鑑別に苦慮したnonmucinous cyctadenoma の1例, 第67回日本消化器画像診断研究会, Sep. 2017. (Keyword) 第67回日本消化器画像診断研究会
442.	Hiroki Mori, Yuji Morine, Keigo Yada, Hiroki Ishibashi and Mitsuo Shimada : 膵・胆管合流異常の胆汁中発癌物質におけるメタボローム解析の検討, 第40回日本膵・胆管合流異常研究会, Sep. 2017.
443.	Hiroki Ishibashi, Yuji Morine, Mitsuo Shimada and 安藤久實 : 先天性胆道拡張症の重症度分類(案)-指定難病取得に向けた取り組み-, 第40回日本膵・胆管合流異常研究会, Sep. 2017.
444.	Hiroki Teraoku, Tetsuya Ikemoto, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Yuuma Wada, Shogo Oota, Satoru Imura and Mitsuo Shimada : Nrf2-Keap1制御系を介したEpigallocatechin-3-gallate(EGCG)による膵島保護作用に関する検討, 第53回日本移植学会総会, Sep. 2017.
445.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Shuichi Iwahashi, Yu Saitou and Hiroki Teraoku : 膵島移植に対するブレイクスルーとしてのAdipose tissue derived stem cellsからの効果的Insulin-producing cells創生, 第53回日本移植学会総会, Sep. 2017.
446.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Hiroki Teraoku, Shuichi Iwahashi, Tetsuya Ikemoto and Yuji Morine : 脳死肝移植を推進するための学生に対するDonor Actionの必要性について, 第53回日本移植学会総会, Sep. 2017.
447.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 赤色発光ダイオード(LED)は肝細胞保護作用を有する, 第255回徳島医学会学術集会, Aug. 2017.
448.	Chie Takasu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, 市井啓仁 and Mitsuo Shimada : 転写因子制御による肝虚血再灌流障害の新たな治療法の開発, 第255回徳島医学会学術集会, Aug. 2017.
449.	Keigo Yada, Hiroki Mori, Hiroki Ishibashi, Yuji Morine and Mitsuo Shimada : 大建中湯は胆道閉鎖症ラットモデルにおけるバクテリアルトランスロケーションと肝線維化を抑制する, 第72回日本消化器外科学会総会, Jul. 2017.
450.	Atsushi Takata, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Yuji Morine, Satoru Imura and Mitsuo Shimada : Epigallocatechin-3-gallate(EGCG)によるNrf2-Keap1制御系を介した膵島保護作用に関する検討, 第72回日本消化器外科学会総, Jul. 2017.
451.	Yu Saitou, Mitsuo Shimada, 瓜生原葉子, Satoru Imura, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Shuichi Iwahashi, Tetsuya Ikemoto and Yuji Morine : 脳死肝移植を推進するための学生に対するDonor Actionの必要性について, 第72回日本消化器外科学会総会, Jul. 2017.
452.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto and Atsushi Takata : One stop shopを目指したEOB-MRIによる部分肝機能評価, 第72回日本消化器外科学会総会, Jul. 2017.
453.	Toshiaki Yoshimoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa and Jun Higashijima : 大腸癌肝転移に切除基準と腫瘍悪性度評価, 第72回日本消化器外科学会総会, Jul. 2017.
454.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Masato Yoshikawa : 肝胆膵手術における人工膵臓血糖管理の有用性に関する検討, 第72回日本消化器外科学会総会, Jul. 2017.
455.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa and Hiroki Teraoku : 肝内胆管癌における局在・浸潤形式別悪性度, 第72回日本消化器外科学会総会, Jul. 2017.
456.	Satoru Imura, Masato Yoshikawa, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 高度門脈侵襲陽性肝癌に対する集学的治療戦略, 第72回日本消化器外科学会総会, Jul. 2017.
457.	Yu Saitou, Hisami Okumura, Yuji Morine, 平山明由, Toshiaki Yoshimoto, Masato Yoshikawa, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : メタボローム解析を用いた肝切除後代謝物解析と肝再生因子の解明, 日本外科代謝栄養学会第54回学術集会, Jul. 2017.
458.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto, Atsushi Takata and Koichi Tsuneyama : 症例, 第53回日本肝癌研究会, Jul. 2017.
459.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Shuichi Iwahashi, Masato Yoshikawa, Toshiaki Yoshimoto and Mitsuo Shimada : 術前Prognostic nutritional index(PNI)は肝癌術後短期・長期予後予測因子になる, 第53回日本肝癌研究会, Jul. 2017.
460.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou and Hiroki Teraoku : 超高齢者に対する肝切除の妥当性に関する検討, 第53回日本肝癌研究会, Jul. 2017.
461.	Satoru Imura, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : ntermediate stage肝癌に対する肝切除の有用性, 第53回日本肝癌研究会, Jul. 2017.
462.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Masato Yoshikawa : NBNC肝細胞癌における臨床病理学的・分子生物学的特徴の解析, 第53回日本肝癌研究会, Jul. 2017.
463.	Shoko Iwahashi, Tetsuya Ikemoto, Mitsuo Shimada, Masato Yoshikawa, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Satoru Imura, Yuji Morine and Koichi Tsuneyama : 単純性嚢胞との鑑別に苦慮した極めて稀な膵嚢胞の1例, 第42回日本外科系連合学会学術集会, Jun. 2017.
464.	Tetsuya Ikemoto, Mitsuo Shimada, Shinsuke Katoh, Masato Yoshikawa, Hiroki Teraoku, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : 徳島大学病院GRMからみた手術室安全管理の取り組み, 第42回日本外科系連合学会学術集会, Jun. 2017.
465.	Yu Saitou, Hiroki Teraoku, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝内胆管癌におけるSFRP1発現低下は予後不良因子となる, 第16回日本肝がん分子標的治療研究会, Jun. 2017.
466.	Shogo Oota, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Hiroki Teraoku : 超高齢者に対する肝切除の妥当性に関する検討-85歳以上の超高齢者にも安全に施行可能である-, 第107回日本消化器病学会四国支部例, Jun. 2017.
467.	Satoru Imura, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Intermediate stageの肝癌に対する切除の有効性の検討, 第53回日本肝臓学会総会, Jun. 2017.
468.	Yuuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa and Mitsuo Shimada : Treatment outcome for recurrent pancreatic cancer, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
469.	Shuichi Iwahashi, AHMAD AMMAR GHAIBEH, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Hiroki Teraoku : Predictability of postoperative recurrence on hepatocellular carcinoma through the alternating decision tree, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
470.	Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saitou and Mitsuo Shimada : Photobiomodulation with red light emitting diodes accelerates hepatocytes proliferation through ROS/ERK pathway, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
471.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou and Masato Yoshikawa : EOB-MRI is useful for `one stop shop` modality based on functional liver volume, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
472.	Masato Yoshikawa, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : Stylization of laparoscopic surgery using 3D simulation for young surgeo, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
473.	Tetsuya Ikemoto, Mitsuo Shimada, Daichi Ishikawa, Masato Yoshikawa, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Yuji Morine : Tr1 cells and Foxp3+regulatory T cell as a diagnostic biomarker for reflecting pathological agressiveness of cystic neoplasm of pancreas, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
474.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa and Hiroki Teraoku : Treatment strategy for colorectal liver matastasis-Surgical criteria for initially resectable and assessment toward conversion for unresectable cases-, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会, Jun. 2017.
475.	Satoru Imura, Atsushi Takata, Toshiaki Yoshimoto, Masato Yoshikawa, Hiroki Teraoku, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Liver resection for hepatocellular carcinoma of BCLC intermediate stage, 第29回日本肝胆膵外科学会学術集会(第6回アジア太平洋肝胆膵学会), Jun. 2017.
476.	Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Mitsuo Shimada : Preoperative prognostic nutritional index (PNI) predicts both short and long-term outcomes after liver resection for hepatocellular carcinoma., IASGO Advanced Postgraduate Course in Yokohama, Jun. 2017.
477.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Shuichi Iwahashi, Tetsuya Ikemoto and Yuji Morine : 脳死肝移植を推進するための学生に対するDonor Actionの必要性について, 第35回日本肝移植研究会, Jun. 2017.
478.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Toshiaki Yoshimoto : Tr1細胞とFoxp3調節性T細胞は消化器担癌状態におけるバイオマーカーとして有用である, 第26回日本癌病態治療研究会, Jun. 2017.
479.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Toshiaki Yoshimoto : 肝葉切除術後に施行した膵切除術2例の経験, 第71回手術手技研究会, May 2017.
480.	宮崎克己, Yu Saitou, Yuji Morine, Koichi Tsuneyama, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Masato Yoshikawa, Toshiaki Yoshimoto, Atsushi Takata and Mitsuo Shimada : 限局性結節性過形成(FNH)術後に再発増殖し肝不全で死亡した一例, 第117回日本外科学会定期学術集会, Apr. 2017.
481.	Shogo Oota, Yuji Morine, Masato Yoshikawa, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Atsushi Takata, Toshiaki Yoshimoto, Chie Takasu, Jun Higashijima and Mitsuo Shimada : 膵癌術後残膵再発に対する再切除導入効果の検証, 第117回日本外科学会定期学術集会, Apr. 2017.
482.	Toshiaki Yoshimoto, Kouzou Yoshikawa, Yuji Morine, Jun Higashijima, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, Atsushi Takata, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 青色LED光は光受容体(opsin)を介し癌細胞増殖を抑制する, 第117回日本外科学会定期学術集会, Apr. 2017.
483.	Masato Yoshikawa, Rui Feng, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Atsushi Takata, Toshiaki Yoshimoto, Chie Takasu, Jun Higashijima and Mitsuo Shimada : 肝細胞に対するROS/ ERK pathwayを介した赤色LED光の細胞増殖促進効果, 第117回日本外科学会定期学術集会, Apr. 2017.
484.	Daichi Ishikawa, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Chie Takasu, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 大腸癌の発癌・腫瘍進展におけるmicroRNA-449aの意義, 第117回日本外科学会定期学術集会, Apr. 2017.
485.	川下陽一郎, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Daichi Ishikawa, Masato Yoshikawa, Atsushi Takata, Toshiaki Yoshimoto, Hiroki Teraoku and Mitsuo Shimada : 肝内胆管癌におけるHSF1発現の意義, 第117回日本外科学会定期学術集会, Apr. 2017.
486.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto and Atsushi Takata : Cancer-associated fibroblastsを介した膵癌細胞におけるnab-paclitaxelの効果, 第117回日本外科学会定期学術集会, Apr. 2017.
487.	Tetsuya Ikemoto, Mitsuo Shimada, Daichi Ishikawa, Yuji Morine, Satoru Imura, Jun Higashijima, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Masato Yoshikawa and Toshiaki Yoshimoto : Tr1細胞とFoxp3調節性T細胞による腫瘍免疫状態を反映する免疫学的バイオマーカー探索, 第117回日本外科学会定期学術集会, Apr. 2017.
488.	Satoru Imura, Atsushi Takata, Toshiaki Yoshimoto, Masato Yoshikawa, Hiroki Teraoku, Daichi Ishikawa, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Jun Higashijima, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝切除シミュレーション・ナビゲーションを駆使した若手教育法の確立, 第117回日本外科学会定期学術集会, Apr. 2017.
489.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa and Toshiaki Yoshimoto : 発光ダイオード(LED)の波長強度可変装置による肝細胞保護に関する研究, 第117回日本外科学会定期学術集会, Apr. 2017.
490.	Yu Saitou, Hisami Okumura, Yuji Morine, 平山明由, 梶浦大資, 多々納浩, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Masato Yoshikawa, Toshiaki Yoshimoto, Atsushi Takata and Mitsuo Shimada : メタボローム解析を用いた肝切除後代謝物解析と肝再生因子の解明, 第117回日本外科学会定期学術集会, Apr. 2017.
491.	Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, Jun Higashijima and Chie Takasu : 大腸癌肝転移における治療指針 - 原発・転移巣の腫瘍悪性度は相関しない?, 第117回日本外科学会定期学術集会, Apr. 2017.
492.	Yuji Morine, Hiroki Ishibashi, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa and Mitsuo Shimada : 「胆道拡張症，膵・胆管合流異常症の標準術式は?-小児外科および成人外科の立場から-」, 第117回日本外科学会定期学術集会, Apr. 2017.
493.	Yu Saitou, Yuji Morine, Masato Yoshikawa, Atsushi Takata, Toshiaki Yoshimoto, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 肝内胆管癌におけるHeat shock factor 1(HSF1)発現の意義, 第50回制癌剤適応研究会, Mar. 2017.
494.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 末梢血Tr1細胞とFoxp3陽性調節性T細胞は消化器担癌状態におけるバイオマーカーとして有用である, 第50回制癌剤適応研究会, Mar. 2017.
495.	Atsushi Takata, Tetsuya Ikemoto, Shuichi Iwahashi, Yuji Morine, Yu Saitou, Satoru Imura and Mitsuo Shimada : Epigallocatechin-3-gallate(EGCG)によるNrf2-Keap1制御系を介した膵島保護作用に関する検討, 第44回日本膵・膵島移植研究会, Mar. 2017.
496.	Tetsuya Ikemoto, Mitsuo Shimada, Shuichi Iwahashi, Toshiaki Yoshimoto, Masato Yoshikawa, Yu Saitou, Yuji Morine and Satoru Imura : 8 ADSCによるInsulin-producing cell(IPCs)作成における効果的新規分化誘導方法に関する検討, 第44回日本膵・膵島移植研究会, Mar. 2017.
497.	Toshiaki Yoshimoto, Yu Saitou, Yuji Morine, Koichi Tsuneyama, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Masato Yoshikawa, Atsushi Takata and Mitsuo Shimada : 限局性結節性過形成(FNH)術後に再発増殖し肝不全で死亡した一例-切除肝・病理解剖をふまえて-, 第66回日本消化器画像診断研究会, Feb. 2017.
498.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 膵腫瘍性病変におけるType1 regulatory T細胞の臨床的有用性の検討-Type1 regulatory T細胞は診断・再発予測バイオマーカーとして有用である-, 第254回徳島医学会学術集会, Feb. 2017.
499.	Yu Saitou, Yuji Morine, Masato Yoshikawa, Atsushi Takata, Toshiaki Yoshimoto, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 肝門部胆管癌超ハイリスク症例に対して根治術施行し術後管理, 第25回徳島外科術後管理研究会, Feb. 2017.
500.	Toshiaki Yoshimoto, Masato Yoshikawa, Daichi Ishikawa, Atsushi Takata, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : Long-term survivors of HCC using sorafenib, 2nd Eastern &Western Association Liver Tumors(EWALT), Jan. 2017.
501.	Masato Yoshikawa, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : 肝細胞癌術後再発予後不良因子としてのCEAの意義, 第15回日本肝がん分子標的治療研究会, Jan. 2017.
502.	Yu Saitou, Yuji Morine, 川下陽一郎, Masato Yoshikawa, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 肝内胆管癌におけるHeat shock factor1(HSF1)発現の意義, 第15回日本肝がん分子標的治療研究会, Jan. 2017.
503.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Keigo Yada, Hiroki Mori and Hiroki Ishibashi : 小児先天性胆道拡張症の胆道上皮における発癌関連遺伝子発現の検討, 第106回日本消化器病学会四国支部例会, Dec. 2016.
504.	Masato Yoshikawa, Rui Feng, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, Masaaki Nishi, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Daichi Ishikawa, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : 肝細胞に対するROS/ERK pathwayを介した赤色LED光の細胞増殖促進効果, 第46回日本創傷治癒学会, Dec. 2016.
505.	Satoru Imura, Masato Yoshikawa, Hiroki Teraoku, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 定型化と教育システムがもたらす安全な腹腔鏡下左葉切除, 第29回日本内視鏡外科学会総会, Dec. 2016.
506.	木下翔平, 多々納浩, 梶浦大資, Hisami Okumura, Mitsuo Shimada, Yuji Morine, 平山明由, 曽我朋義 and 冨田勝 : 患者組織と腫瘍切除前後の血清を用いたメタボローム解析による新規バイオマーカ探索, 分子細胞生物学会, Nov. 2016.
507.	Masato Yoshikawa, Yu Saitou, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Daichi Ishikawa, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : 若手医師による術前術中3D simulation画像を用いた腹腔鏡下手術の定型化, 第25回日本コンピュータ外科学会大会, Nov. 2016.
508.	Toshiaki Yoshimoto, Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Atsushi Takata and Chie Takasu : EOB-MRIを用いた新たな肝切除限界予測の可能性, 第78回日本臨床外科学会総会, Nov. 2016.
509.	Masato Yoshikawa, Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Atsushi Takata and Toshiaki Yoshimoto : 再発膵癌に対する再切除の有用性の検討, 第78回日本臨床外科学会総会, Nov. 2016.
510.	Atsushi Takata, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa and Toshiaki Yoshimoto : 当科における若手医師の腹腔鏡手術トレーニングの現状と効果, 第78回日本臨床外科学会総会, Nov. 2016.
511.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 若手外科医でも安全・確実に施行できる肝葉切除術, 第78回日本臨床外科学会総会, Nov. 2016.
512.	Yu Saitou, Yuji Morine, Atsushi Takata, Toshiaki Yoshimoto, Masato Yoshikawa, Daichi Ishikawa, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : 膵頭十二指腸切除術に対するModified de-rotation法を用いた`` Complete artery-f irst approach'', 第78回日本臨床外科学会総会, Nov. 2016.
513.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa and Toshiaki Yoshimoto : 膵全摘における人工膵臓の有用性における検討, 第78回日本臨床外科学会総会, Nov. 2016.
514.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Hiroki Teraoku, Masato Yoshikawa, Chie Takasu, Yusuke Arakawa and Jun Higashijima : 大腸癌切除不能多発肝転移に対する治療戦略, 第78回日本臨床外科学会総会, Nov. 2016.
515.	Satoru Imura, Masato Yoshikawa, Hiroki Teraoku, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : グリソン一括による肝門処理のコツとピットフォール, 第78回日本臨床外科学会総会, Nov. 2016.
516.	Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝臓外科からみた経皮的RFA不適となる肝癌の特徴∼切除例における組織学的門脈侵襲の解析から∼, JDDW2016, Nov. 2016.
517.	Masato Yoshikawa, Yuji Morine, Tetsuya Ikemoto, Atsushi Takata, Toshiaki Yoshimoto, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Mitsuo Shimada : 当科における切除不能・再発進行膵癌に対する治療成績, 第54回日本癌治療学会学術集会, Oct. 2016.
518.	Daichi Ishikawa, 川下陽一郎, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : FBXW7発現は転移性肝癌における切除後再発予測因子となる, 第54回日本癌治療学会学術集会, Oct. 2016.
519.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : 末梢血Tr1細胞とFoxp3調節性T細胞は担癌状態におけるバイオメーカーとして有用である, 第54回日本癌治療学会学術集会, Oct. 2016.
520.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Daichi Ishikawa and Masato Yoshikawa : 消化器癌におけるヒストンアセチル化の抗腫瘍効果, 第75回日本癌学会学術集会, Oct. 2016.
521.	Tetsuya Ikemoto, Mitsuo Shimada, Daichi Ishikawa, Yuji Morine, Satoru Imura, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Toshiaki Yoshimoto : Tr1とFoxp3陽性調節性T細胞は担癌患者の腫瘍免疫に関する検討, 第75回日本癌学会学術集会, Oct. 2016.
522.	Toshiaki Yoshimoto, Yu Saitou, Atsushi Takata, Masato Yoshikawa, Daichi Ishikawa, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 脳死肝移植を推進するための学生に対するドナーアクションの必要性について, 第52回日本移植学会総会, Sep. 2016.
523.	Yu Saitou, Satoru Imura, Masato Yoshikawa, Daichi Ishikawa, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 徳島におけるABO不適合生体肝移植の成績, 第52回日本移植学会総会, Sep. 2016.
524.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Shuichi Iwahashi, Yu Saitou, Masato Yoshikawa and Toshiaki Yoshimoto : 脂肪由来幹細胞によるInsulin-producing cell作成における新規分化誘導方法に関する検討, 第52回日本移植学会総会, Sep. 2016.
525.	Atsushi Takata, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa and Toshiaki Yoshimoto : 術前診断が困難であった肝偽リンパ腫の1例, 第65回日本消化器画像診断研究会, Sep. 2016.
526.	Atsushi Takata, Toshiaki Yoshimoto, Masato Yoshikawa, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 若手医師による術前術中3D simulation画像を用いた腹腔鏡下手術の定型化, 第11回肝癌治療シミュレーション研究会, Sep. 2016.
527.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Toshiaki Yoshimoto and Atsushi Takata : RFA後肝細胞癌再発例はEMT誘導を介し腫瘍悪性度が増強する, 第35回Microwave Surgery研究会, Sep. 2016.
528.	Satoru Imura, Masato Yoshikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 担癌グリソン枝マイクロ波凝固による肝小範囲切除の工夫, 第35回Microwave Surgery研究会, Sep. 2016.
529.	馮睿, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Atsushi Takata and Toshiaki Yoshimoto : Cancer-associated fibroblastsに着目した膵癌細胞におけるnab-paclitaxcelの効果, 第27回日本消化器癌発生学会総会, Sep. 2016.
530.	Masato Yoshikawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Atsushi Takata and Toshiaki Yoshimoto : 肝細胞癌術後再発予後不良因子としてのCEAの意義, 第27回日本消化器癌発生学会総会, Sep. 2016.
531.	Daichi Ishikawa, Hiroki Teraoku, Atsushi Takata, Masato Yoshikawa, Chie Takasu, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 転移性肝癌における腫瘍悪性度制御因子としてのTHBS-1の役割, 第27回日本消化器癌発生学会総会, Sep. 2016.
532.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 消化器癌における末梢血Tr1細胞とFoxp3調節性T細胞の有用性の検討, 第27回日本消化器癌発生学会総会, Sep. 2016.
533.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Hiroki Teraoku and Masato Yoshikawa : 肝内胆管癌の腫瘍悪性度評価と制御の可能性, 第27回日本消化器癌発生学会総会, Sep. 2016.
534.	Yuji Morine, Mitsuo Shimada, 窪田正幸, Hiroki Ishibashi and 安藤久實 : 膵・胆管合流異常症に対する術式選択の特徴―全国集計解析から―, 第39回日本膵・胆管合流異常研究会, Sep. 2016.
535.	Atsushi Takata, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa and Toshiaki Yoshimoto : 胆道癌術後肝内再発に対する肝切除導入効果の検証, 第91回中国四国外科学会総会/第21回中国四国内視鏡外科研究会, Sep. 2016.
536.	Chie Takasu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, 市井啓仁 and Mitsuo Shimada : 転写因子制御による肝虚血再灌流障害の新たな治療法の開発., 第253回徳島医学会学術集会, Jul. 2016.
537.	Yu Saitou, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : Boot Camp in Tokushima University., 第71回日本消化器外科学会総会, Jul. 2016.
538.	Yu Saitou, Atsushi Takata, Hiroki Teraoku, Masato Yoshikawa, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : The analysis in non-tumor liver tissue to prevent the recurrence after curative treatment of hepatocellular carcinoma., 第71回日本消化器外科学会総会, Jul. 2016.
539.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa and Hiroki Teraoku : A new strategy forachieving effective islet transplantation with adipose tissue derved stem cells., 第71回日本消化器外科学会総会, Jul. 2016.
540.	Yuji Morine, Mitsuo Shimada, Hiroki Ishibashi, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa and Masato Yoshikawa : 全国集計からみた膵・胆管合流異常症の臨床摘特徴と術式選択の現状., 第71回日本消化器外科学会総会, Jul. 2016.
541.	Satoru Imura, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Yuji Morine, Mitsuo Shimada and 住友正幸 : へき地病院から専門医を輩出するための地域外科診療部の役割, 第71回日本消化器外科学会総会, Jul. 2016.
542.	Kouzou Yoshikawa, Mitsuo Shimada, Jun Higashijima, Toshihiro Nakao, Yuji Morine, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Toshiaki Yoshimoto and Hiroki Teraoku : 青色LED光は癌細胞増殖を抑制する., 第71回日本消化器外科学会総会, Jul. 2016.
543.	Keigo Yada, Hiroki Ishibashi, Hiroki Mori, Toshiaki Yoshimoto, Yuji Morine and Mitsuo Shimada : 大建中湯(TU-100)はTLR4/TNFαを介して総胆管結紮ラットモデルにおける肝障害を抑制する., 第23回外科侵襲とサイトカイン研究会, Jul. 2016.
544.	Masato Yoshikawa, Yu Saitou, Satoru Imura, Toshiaki Yoshimoto, Atsushi Takata, Daichi Ishikawa, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : ABO不適合生体肝移植後にCMV感染治療に難渋した一例., 第34回日本肝移植研究会, Jul. 2016.
545.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : NO阻害と転写活性制御からの虚血再灌流障害., 第34回日本肝移植研究会, Jul. 2016.
546.	Yu Saitou, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 脳死肝移植を推進するための学生に対するドナーアクションの必要性について., 第34回日本肝移植研究会, Jul. 2016.
547.	Yu Saitou, Sonoko Yasui, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : 肝硬変合併肝切除症例における栄養・免疫状態の特徴, 第52回日本肝癌研究会, Jul. 2016.
548.	Toshiaki Yoshimoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Masato Yoshikawa and Atsushi Takata : 症例, 第52回日本肝癌研究会, Jul. 2016.
549.	Satoru Imura, Masato Yoshikawa, Hiroki Teraoku, Daichi Ishikawa, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : Intermediate stageの肝癌に対する肝切除は有効か?, 第52回日本肝癌研究会, Jul. 2016.
550.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Masato Yoshikawa : 肝内胆管癌における発生部位別悪性度., 第52回日本肝癌研究会, Jul. 2016.
551.	Toshiaki Yoshimoto, Kouzou Yoshikawa, 松本規子, Atsushi Takata, Yu Saitou, Masato Yoshikawa, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Daichi Ishikawa, Shuichi Iwahashi and Mitsuo Shimada : 青色LED光のヒト癌細胞株に対する効果., 第105回日本消化器病学会四国支部例会, Jun. 2016.
552.	Masato Yoshikawa, Yuji Morine, Tetsuya Ikemoto, Atsushi Takata, Toshiaki Yoshimoto, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Satoru Imura and Mitsuo Shimada : 切除不能・再発進行膵癌に対する治療成績., 第105回日本消化器病学会四国支部例会, Jun. 2016.
553.	Atsushi Takata, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Yusuke Arakawa, Shuichi Iwahashi, Daichi Ishikawa, Masato Yoshikawa, Hiroki Teraoku and Toshiaki Yoshimoto : HCCに対して初回RFA治療早期にリンパ節再発をきたし外科的切除を施行した症例., 第41回日本外科系連合学会学術集会, Jun. 2016.
554.	Yu Saitou, Atsushi Takata, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : PDに対するModified de-rotationを用いた``Complate artery-firstn approach''., 第41回日本外科系連合学会学術集会, Jun. 2016.
555.	Toshiaki Yoshimoto, C Enkbold, Atsushi Takata, Masato Yoshikawa, Daichi Ishikawa, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 肝内胆管癌における細胞周期調節因子Fbxw7発現低下の臨床病理学的意義., 第14回日本肝がん分子標的治療研究会, Jun. 2016.
556.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Daichi Ishikawa, Masato Yoshikawa, Toshiaki Yoshimoto and Atsushi Takata : RFA後肝細胞癌再発例はEMT誘導を介し腫瘍悪性度が増強する., 第14回日本肝がん分子標的治療研究会, Jun. 2016.
557.	Kouzou Yoshikawa, Mitsuo Shimada and Yuji Morine : 肝切除周術期における大建中湯の有用性., 第67回日本東洋医学会学術総会, Jun. 2016.
558.	Kouzou Yoshikawa, Mitsuo Shimada, Yuji Morine and Chie Takasu : 外科の立場から見た癌治療における漢方の役割-From bench to bedside-., 第67回日本東洋医学会学術総会, Jun. 2016.
559.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : EOB-MRIを用いた機能的肝容積による新たな肝切除基準., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
560.	Tetsuya Ikemoto, Mitsuo Shimada, Daichi Ishikawa, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku and Masato Yoshikawa : Tr1細胞とFoxp3調節性T細胞による膵嚢胞性疾患に関する正確な免疫学的指標探索に関する研究., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
561.	Yu Saitou, Atsushi Takata, Hiroki Teraoku, Masato Yoshikawa, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 胆道癌術後肝内再発に対する肝切除導入効果の検証., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
562.	Masato Yoshikawa, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Atsushi Takata, Toshiaki Yoshimoto and Mitsuo Shimada : 当科における胆道再建における肝管空腸吻合法の工夫., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
563.	Hiroki Teraoku, Yuji Morine, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa, Chie Takasu, Jun Higashijima, 川下陽一郎, Atsushi Takata, Toshiaki Yoshimoto, Satoru Imura and Mitsuo Shimada : 大腸癌肝転移肝切除症例におけるThrombospondin1(THBS)発現の意義とその分子メカニズムの検討., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
564.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Masato Yoshikawa and Jun Higashijima : 大腸癌多発肝転移に対する長期生存を目指した治療戦略., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
565.	Satoru Imura, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 門脈・肝静脈解剖に基づく合理的な系統的肝切除∼副右肝静脈灌流領域切除を伴う拡大前区域切除., 第28回日本肝胆膵外科学会・学術集会, Jun. 2016.
566.	Masato Yoshikawa, Yuji Morine and Mitsuo Shimada : 肝細胞癌におけるNEK2発現による腫瘍悪性度評価., 第52回日本肝臓学会総会, May 2016.
567.	Yu Saitou, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 徳島におけるABO不適合生体肝移植症例の成績., 第42回日本急性肝不全研究会, May 2016.
568.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, 川下陽一郎, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 転移性肝癌における腫瘍悪性度制御因子としてのHIF-1の役割., 第102回日本消化器病学会総会, Apr. 2016.
569.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Masato Yoshikawa, Hiroki Teraoku, Toshiaki Yoshimoto, Atsushi Takata and Chie Takasu : EOB-MRIを用いた新たな肝切除基準の可能性, 第102回日本消化器病学会総会, Apr. 2016.
570.	Shogo Oota, Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Kouzou Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 胆道癌術後肝内再発に対する肝切除導入効果の検証, 第116回日本外科学会定期学術集会, Apr. 2016.
571.	Shoko Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, 川下陽一郎, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Masato Yoshikawa, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : 急速な進展を来したラブドイド様退形成性癌の一例., 第116回日本外科学会定期学術集会, Apr. 2016.
572.	関勇輔, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, 川下陽一郎, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Masato Yoshikawa, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : RFA術後にリンパ節再発をきたし外科切除を施行した肝細胞癌の1例 -RFA術後再発におけるEMT誘導を介した悪性度獲得について-., 第116回日本外科学会定期学術集会, Apr. 2016.
573.	川下陽一郎, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Higashijima, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Hiroki Teraoku, Masato Yoshikawa, Atsushi Takata, Toshiaki Yoshimoto and Hirohisa Ogawa : 転移性肝癌におけるFbxw7低発現は再発予測因子である., 第116回日本外科学会定期学術集会, Apr. 2016.
574.	Masato Yoshikawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Hiroki Teraoku, Atsushi Takata and Toshiaki Yoshimoto : 肝細胞癌術後再発予後不良因子としてのCEAの意義, 第116回日本外科学会定期学術集会, Apr. 2016.
575.	Hiroki Teraoku, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, 川下陽一郎, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, Masato Yoshikawa, Atsushi Takata and Toshiaki Yoshimoto : 転移性肝癌における腫瘍悪性度制御因子としてのThrombospondin-1(THBS-1)の役割- 第2報 THBS-1制御メカニズムについて -, 第116回日本外科学会定期学術集会, Apr. 2016.
576.	Shin-ichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Kouzou Yoshikawa, Hiroki Teraoku, Toshiaki Yoshimoto, Atsushi Takata and Chie Takasu : EOB-MRIを用いた新たな肝切除基準の可能性., 第116回日本外科学会定期学術集会, Apr. 2016.
577.	Yu Saitou, Toshiaki Yoshimoto, Atsushi Takata, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : HDAC阻害剤は脂肪由来幹細胞からインスリン分泌細胞への分化誘導を促進する., 第116回日本外科学会定期学術集会, Apr. 2016.
578.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, Daichi Ishikawa, Hiroki Teraoku and Masato Yoshikawa : 肝内胆管癌に対する至適術式と集学的治療., 第116回日本外科学会定期学術集会, Apr. 2016.
579.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Kouzou Yoshikawa, 寺奥大貴, 高田厚史 and 良元俊昭 : 肝細胞癌症例におけるNEK2発現による腫瘍悪性度評価, 第49回制癌剤適応研究会, Mar. 2016.
580.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, Masato Yoshikawa, Hiroki Teraoku and Toshiaki Yoshimoto : 脂肪由来幹細胞による膵島移植・膵島再生に関する新たな戦略, 第43回日本膵・膵島移植研究会, Mar. 2016.
581.	Yu Saitou, Masato Yoshikawa, Hiroki Teraoku, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 36.3mm細径鉗子を用いたreduced port Lap-Cに関する検討, 第30回四国内視鏡外科研究会, Feb. 2016.
582.	寺奥大貴, Mitsuo Shimada, 石川大地, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, 吉川雅登, 高田厚史 and 良元俊昭 : 消化器担癌状態のバイオマーカーとしての末梢血Tr1細胞とFoxp3調節性T細胞の有用性に関する検討, 第252回徳島医学会学術集会, Feb. 2016.
583.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, 吉川雅登, 寺奥大貴 and 高田厚史 : 肝細胞癌症例におけるNEK2発現による腫瘍悪性度評価, 第252回徳島医学会学術集会, Feb. 2016.
584.	良元俊昭, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada and 高田厚史 : Sorafenib+poly surgeryによるHCC長期生存例∼orafenib投与長期生存条件の検討∼, 第13回日本肝がん分子標的治療研究会, Jan. 2016.
585.	寺奥大貴, 朱呈瞻, 髙田厚史, 良元俊昭, 吉川雅登, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 加齢肝再生における肝星細胞の役割, 第22回外科侵襲とサイトカイン研究会, Dec. 2015.
586.	髙田厚史, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 吉川雅登 and 寺奥大貴 : HCCに対して初回RFA治療後早期にリンパ節再発をきたし外科的切除を施行した症例, 第41回日本肝臓学会西部会, Dec. 2015.
587.	吉川雅登, Shin-ichiro Yamada, 髙田厚史, 良元俊昭, 寺奥大貴, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝内胆管癌との鑑別が困難であった原発性放線菌症の一例, 第41回日本肝臓学会西部会, Dec. 2015.
588.	Satoru Imura, Yuji Morine and Mitsuo Shimada : 非癌部における肝発癌分子機構の検討 ∼癌幹細胞関連DNA・miRNA発現に着目して∼, 第41回日本肝臓学会西部会, Dec. 2015.
589.	吉川雅登, Wubetu Gizachew Yismaw, 髙田厚史, 良元俊昭, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 脂肪由来幹細胞からインスリン分泌細胞への分化誘導におけるバルプロ酸の分化促進, 第45回日本創傷治癒学会, Nov. 2015.
590.	吉川雅登, Shin-ichiro Yamada, 髙田厚史, 良元俊昭, 寺奥大貴, Yu Saitou, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Hiroshi Shibata, Hidenori Miyake and Mitsuo Shimada : ソラフェニブ投与後長期生存例の検討∼切除を含む集学的治療の重要性∼, 第77回日本臨床外科学会総会, Nov. 2015.
591.	寺奥大貴, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Higashijima, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, 吉川雅登, 髙田厚史 and 良元俊昭 : 若手外科医教育のための膵頭十二指腸切除における3D simulationの有用性, 第77回日本臨床外科学会総会, Nov. 2015.
592.	Yu Saitou, Sonoko Yasui, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : 肝胆膵外科手術における免疫指標を加味した新たな周術期栄養評価, 第77回日本臨床外科学会総会, Nov. 2015.
593.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登, Chie Takasu and Jun Higashijima : 大腸癌多発肝転移に対する治療戦略, 第77回日本臨床外科学会総会, Nov. 2015.
594.	Satoru Imura, 髙田厚史, 良元俊昭, 寺奥大貴, 吉川雅登, Shin-ichiro Yamada, Chie Takasu, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝臓外科における画像シミュレーション, 第77回日本臨床外科学会総会, Nov. 2015.
595.	Satoru Imura, 髙田厚史, 良元俊昭, 寺奥大貴, 吉川雅登, Shin-ichiro Yamada, Chie Takasu, Yu Saitou, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝切除における高齢者の特徴と戦略, 第77回日本臨床外科学会総会, Nov. 2015.
596.	Shin-ichiro Yamada, 良元俊昭, 髙田厚史, 寺奥大貴, 吉川雅登, Yu Saitou, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 腹腔鏡下肝切除術の適応拡大と標準化への工夫安全な腹腔鏡下肝切除の標準化に向けて ∼適応拡大に先立つ着実な手技の定型化∼, 第9回肝臓内視鏡外科研究会, Nov. 2015.
597.	吉川雅登, Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, 寺奥大貴, 髙田厚史 and 良元俊昭 : 分肝機能に着目したEOB-MRIによる肝予備能評価の有用性, 第24回日本コンピュータ外科学会大会, Nov. 2015.
598.	寺奥大貴, 髙田厚史, 良元俊昭, 吉川雅登, Shin-ichiro Yamada, Yu Saitou, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 肝内胆管癌におけるFbxw7発現低下と臨床病理学的意義 - 細胞増殖・EMT誘導との関連に着目して -, 第26回日本消化器癌発生学会総会, Nov. 2015.
599.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 肝細胞癌におけるEpigenetic遺伝子制御の可能性, 第26回日本消化器癌発生学会総会, Nov. 2015.
600.	寺奥大貴, Shin-ichiro Yamada, 良元俊昭, 高田厚史, 吉川雅登, Yu Saitou, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Mitsuo Shimada and Hidenori Miyake : RFA術後にリンパ節再発をきたし外科切除を施行した肝細胞癌の1例 -RFA術後再発におけるEMT誘導を介した悪性度獲得について-, 日本消化器病学会四国支部第104回例会, Nov. 2015.
601.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, 吉川雅登 and 寺奥大貴 : 肝細胞癌症例におけるNEK2発現の意義に関する検討, 第53回日本癌治療学会学術集会, Oct. 2015.
602.	髙田厚史, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 大腸癌肝転移症例における肝転移巣のKISS1発現に関する検討, 第53回日本癌治療学会学術集会, Oct. 2015.
603.	寺奥大貴, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Higashijima, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, 石川大地 and 吉川雅登 : 大腸癌肝転移肝切除症例におけるThrombospondin-1(THBS1)発現の意義, 第74回日本癌学会学術総会, Oct. 2015.
604.	Tetsuya Ikemoto, Mitsuo Shimada, 石川大地, 寺奥大貴, 吉川雅登, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Satoru Imura and Yuji Morine : Tr1細胞と調節性T細胞の坦癌患者における臨床的意義に関する研究, 第74回日本癌学会学術総会, Oct. 2015.
605.	Tetsuya Ikemoto, Mitsuo Shimada, 石川大地, Yuji Morine, Satoru Imura, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登 and 良元俊昭 : Tr1細胞とFoxp3調節性T細胞による消化器担癌状態の正確な診断バイオマーカー探索に関する研究, JDDW 2015, Oct. 2015.
606.	吉川雅登, Chie Takasu, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 市井啓仁 and Mitsuo Shimada : NO阻害と転写活性制御に着目した虚血再灌流傷害治療に向けた基礎的検討, 第51回日本移植学会総会, Oct. 2015.
607.	Shin-ichiro Yamada, Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yu Saitou, Chie Takasu, 吉川雅登, 寺奥大貴, 髙田厚史 and 良元俊昭 : 脳死肝移植を推進するための学生に対するドナーアクションの必要性について, 第51回日本移植学会総会, Oct. 2015.
608.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 脂肪由来幹細胞が拓く膵島細胞移植成績向上に関する展望と課題, 第51回日本移植学会総会, Oct. 2015.
609.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 肝内胆管癌に対する至適術式と集学的治療戦略, 第51回日本肝癌研究会, Jul. 2015.
610.	Satoru Imura, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 脾機能亢進症を合併した肝癌に対する脾摘+肝切除の有用性, 第51回日本肝癌研究会, Jul. 2015.
611.	吉川雅登, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Chie Takasu and Shin-ichiro Yamada : 肝細胞癌における腫瘍マーカー発現とEpithelial-mesenchymal transitionに関する検討, 第70回日本消化器外科学会総会, Jul. 2015.
612.	寺奥大貴, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 吉川雅登 : 大腸癌肝転移における腫瘍内Ki67発現の意義, 第70回日本消化器外科学会総会, Jul. 2015.
613.	Shin-ichiro Yamada, 吉川雅登, 寺奥大貴, Satoru Imura, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 安全な腹腔鏡下切除の標準化に向けて∼適応拡大に先立つ着実な手技の定型化∼, 第70回日本消化器外科学会総会, Jul. 2015.
614.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, 吉川雅登 and 寺奥大貴 : 肝予備能評価におけるEOB-MRI肝細胞相の有用性の検討, 第70回日本消化器外科学会総会, Jul. 2015.
615.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Kouzou Yoshikawa, Yusuke Arakawa, Shuichi Iwahashi, Keigo Yada, Yu Saitou and Shin-ichiro Yamada : 肝切除周術期におけるTU-100に関するトランスレーショナルリサーチ, 第70回日本消化器外科学会総会, Jul. 2015.
616.	Yusuke Arakawa, Mitsuo Shimada, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 小胞体ストレス応対に着目した加齢肝再生不全における肝星細胞の役割についての検討, 第70回日本消化器外科学会総会, Jul. 2015.
617.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 肝内胆管癌に対する至適術式と集学的治療戦略, 第70回日本消化器外科学会総会, Jul. 2015.
618.	Satoru Imura, Takuya Tokunaga, Jun Higashijima, Kouzou Yoshikawa, Yuji Morine, 住友正幸 and Mitsuo Shimada : へき地病院から専門医を輩出するための地域外科診療部の活用, 第70回日本消化器外科学会総会, Jul. 2015.
619.	Yu Saitou, Sonoko Yasui, 寺奥大貴, 吉川雅登, Shin-ichiro Yamada, Chie Takasu, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : 肝胆膵外科手術における周術期栄養評価の有用性に関する研究-体成分分析装置と主観的包括的アセスメントSGA -, 日本外科代謝栄養学会第52回学術集会, Jul. 2015.
620.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登 and Gizachew Yismaw : Epigallocatechin gallateはABCトランスポーターを介してstemnessを解除する, 第24 回日本癌病態治療研究会, Jun. 2015.
621.	吉川雅登, Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, 石川大地, 寺奥大貴, 良元俊昭, 髙田厚史 and Hidenori Miyake : 肝細胞癌切除症例に対するRFA後肝細胞癌再発例はEMT誘導を介して予後不良となる, 第103回例会日本消化器病学会総会四国支部, Jun. 2015.
622.	Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Hiroshi Shibata, Hidenori Miyake and Mitsuo Shimada : ソラフェニブ投与後長期生存例の検証-切除を含む集学的治療の重要性-, 第103回例会日本消化器病学会総会四国支部, Jun. 2015.
623.	Yu Saitou, Sonoko Yasui, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : 肝胆膵外科手術におけるNST介入による周術期栄養評価, 第40回日本外科系連合学会学術集会, Jun. 2015.
624.	良元俊昭, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, 寺奥大貴 and 吉川雅登 : 若手外科医にも安全な3mm細径鉗子を用いたreduced port Lap-C, 第40回日本外科系連合学会学術集会, Jun. 2015.
625.	Yu Saitou, Sonoko Yasui, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : 肝胆膵外科手術における周術期栄養評価の有用性に関する研究‐体成分分析装置と主観的包括的アセスメント‐, 第27回日本肝胆膵外科学会, Jun. 2015.
626.	吉川雅登, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 石川大地 and 寺奥大貴 : 肝細胞癌における腫瘍マーカー発現とEMTに関する検討, 第27回日本肝胆膵外科学会, Jun. 2015.
627.	寺奥大貴, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Jun Higashijima, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, 石川大地 and 吉川雅登 : 大腸癌肝転移肝切除症例におけるThrombospondin-1(THBS1)発現の意義, 第27回日本肝胆膵外科学会, Jun. 2015.
628.	Shin-ichiro Yamada, 吉川雅登, 寺奥大貴, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Yusuke Arakawa, Jun Higashijima, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 脾機能亢進症を合併した肝癌に対する脾摘+肝切除の有用性, 第27回日本肝胆膵外科学会, Jun. 2015.
629.	Yu Saitou, エンヘボルトチンボルト, 吉川雅登, 寺奥大貴, 石川大地, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 肝内胆管癌におけるFbxw7発現低下と臨床病理的意義-細胞増殖・EMT誘導との関連-, 第27回日本肝胆膵外科学会, Jun. 2015.
630.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, 吉川雅登 and 寺奥大貴 : 3mm細径鉗子を用いたreduced port Lap-C, 第27回日本肝胆膵外科学会, Jun. 2015.
631.	Yusuke Arakawa, Mitsuo Shimada, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 下右肝静脈温存，上中右肝静脈ドレナージ領域を含む合理的拡大肝前区域切除術, 第27回日本肝胆膵外科学会, Jun. 2015.
632.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登 and 良元俊昭 : Borderline resectable膵癌に対する治療成績の検討, 第27回日本肝胆膵外科学会, Jun. 2015.
633.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴, 吉川雅登 and 良元俊昭 : 指導医の立場から見た若手外科医教育のための膵頭十二指腸切除における3Dsimulationの有用性, 第27回日本肝胆膵外科学会, Jun. 2015.
634.	Satoru Imura, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 肝予備能評価におけるEOB-MRI肝細胞相の有用性, 第27回日本肝胆膵外科学会, Jun. 2015.
635.	Shin-ichiro Yamada, 吉川雅登, 寺奥大貴, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 安全な腹腔鏡下肝切除の標準化に向けて-左葉系肝切除における着実な手技の定型化-, 第27回日本肝胆膵外科学会, Jun. 2015.
636.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 肝内胆管癌に対する至適術式と集学的治療戦略, 第27回日本肝胆膵外科学会, Jun. 2015.
637.	Satoru Imura, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 吻合部狭窄のない胆管-胆管吻合手技の工夫-, 第33回日本肝移植研究会, May 2015.
638.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shuichi Iwahashi, Yu Saitou, 吉川雅登 and 寺奥大貴 : 分肝機能に着目したEOB-MRIによる肝予備能評価の有用性, 第51回日本肝臓学会総会, May 2015.
639.	Shuichi Iwahashi, Mitsuo Shimada, Tatsuya Taniguchi, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saitou, Shin-ichiro Yamada and 楠本彩子 : 当県肝疾患診療における円滑な地域連携推進のための活動について, 第51回日本肝臓学会総会, May 2015.
640.	Satoru Imura, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 脾機能亢進症を合併した肝癌に対する非的+肝切除の有用性, 第51回日本肝臓学会総会, May 2015.
641.	Yu Saitou, Shin-ichiro Yamada, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝不全におけるMEIN投与の有用性-基礎から臨床-, 第41回日本急性肝不全研究会, May 2015.
642.	Shin-ichiro Yamada, 吉川雅登, 寺奥大貴, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 若手外科医教育のための膵頭十二指腸切除における3D simulationの有用性, 第69回手術手技研究会, May 2015.
643.	Yu Saitou, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 術前3Dシミュレーションを使用した膵頭十二指腸切除におけるmodified de-rotation, 第69回手術手技研究会, May 2015.
644.	Shuichi Iwahashi, Mitsuo Shimada, 寺奥大貴, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, Jun Higashijima, Chie Takasu and 吉川雅登 : Epigallocatechin gallateの消化器癌における抗腫瘍効果の検討, 第101回日本消化器病学会総会, Apr. 2015.
645.	Yuji Morine, Mitsuo Shimada and Jun Higashijima : 大腸癌多発肝転移に対する治療戦略, 第101回日本消化器病学会総会, Apr. 2015.
646.	Chie Takasu, Yuji Morine, Satoru Imura, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 石川大地 and Mitsuo Shimada : 肝虚血再灌流障害の発生・進展機序の解明と統合的治療法開発の取り組み, 第115回日本外科学会定期学術集会, Apr. 2015.
647.	Keigo Yada, Hiroki Mori, Hiroki Ishibashi, Chie Takasu, 寺奥大貴, 吉川雅登, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 大建中湯(TU-100)は胆道閉鎖症ラットモデル由来の肝星細胞活性化を抑制する, 第115回日本外科学会定期学術集会, Apr. 2015.
648.	太田昇吾, Yu Saitou, 吉川雅登, 寺奥大貴, 石川大地, Shin-ichiro Yamada, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : ソラフェニブ投与後切除可能となり長期生存が得られたFGF4強発現進行肝細胞癌の症例, 第115回日本外科学会定期学術集会, Apr. 2015.
649.	髙田厚史, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 吉川雅登 and 寺奥大貴 : 大腸癌肝転移症例における肝転移巣のKiss1発現は独立予後規定因子となる, 第115回日本外科学会定期学術集会, Apr. 2015.
650.	石川大地, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : 大腸癌におけるmicroRNA-449a発現の意義, 第115回日本外科学会定期学術集会, Apr. 2015.
651.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, 石川大地, 寺奥大貴 and 吉川雅登 : 肝内胆管癌における細胞周期調節因子Fbxw7の発現低下は独立予後規定因子である, 第115回日本外科学会定期学術集会, Apr. 2015.
652.	吉川雅登, 寺奥大貴, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Yusuke Arakawa, Jun Higashijima, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝細胞癌における腫瘍マーカー発現は無再発予後因子となる, 第115回日本外科学会定期学術集会, Apr. 2015.
653.	寺奥大貴, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Jun Higashijima, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Shin-ichiro Yamada, 石川大地 and 吉川雅登 : 大腸癌肝転移におけるThrombospondin-1(THBS1)発現の意義, 第115回日本外科学会定期学術集会, Apr. 2015.
654.	Yusuke Arakawa, Mitsuo Shimada, 寺奥大貴, 吉川雅登, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Jun Higashijima : 加齢肝再生不全における肝星細胞の役割についての検討, 第115回日本外科学会定期学術集会, Apr. 2015.
655.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and 吉川雅登 : Epigallocatechin gallateはABCトランスポーター関連因子を介して抗腫瘍効果を発揮する, 第115回日本外科学会定期学術集会, Apr. 2015.
656.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Jun Higashijima, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 術前3DシミュレーションおよびVSSを使用した膵頭十二指腸切除における modified de-rotation method, 第115回日本外科学会定期学術集会, Apr. 2015.
657.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 石川大地, 寺奥大貴, Chie Takasu, Jun Higashijima and Hidenori Miyake : 大腸癌多発肝転移に対する長期生存を目指した治療戦略, 第115回日本外科学会定期学術集会, Apr. 2015.
658.	Satoru Imura, Shuichi Iwahashi, Yusuke Arakawa, Jun Higashijima, Tetsuya Ikemoto, Yuji Morine, Hidenori Miyake, Mitsuo Shimada, 吉川雅登, 寺奥大貴, 石川大地, Shin-ichiro Yamada, Yu Saitou and Chie Takasu : 手技定型化が可能にした門脈·肝静脈解剖に基づく合理的な系統的肝切除-副右肝静脈灌流領域切除を伴う拡大前区域切除術-, 第115回日本外科学会定期学術集会, Apr. 2015.
659.	Yu Saitou, Sonoko Yasui, 吉川雅登, 寺奥大貴, Shin-ichiro Yamada, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : 肝胆膵外科手術における周術期栄養評価の有用性に関する研究-体成分分析装置と主観的包括アセスメントSGA-, 第115日本外科学会定期学術集会, Apr. 2015.
660.	吉川雅登, 良元俊昭, 寺奥大貴, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : 肝門部胆管癌に対する拡大肝右葉切除後，門脈血栓・大量腹水により管理に難渋した1例, 第23回徳島外科術後管理研究会, Feb. 2015.
661.	吉川雅登, Mitsuo Shimada, 寺奥大貴, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Yusuke Arakawa, Jun Higashijima, Tetsuya Ikemoto, Satoru Imura and Yuji Morine : 肝細胞癌における腫瘍マーカー発現は無再発予後因子となる, 第250回徳島医学会学術集会, Feb. 2015.
662.	Keigo Yada, Hiroki Ishibashi, Yuji Morine and Mitsuo Shimada : 大建中湯(TU-100)は胆道閉鎖症ラットモデルにおける肝線維化を抑制する, 第250回徳島医学会学術集会, Feb. 2015. (Keyword) 国内学会
663.	Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Mitsuo Shimada : ソラフェニブ投与後長期生存例の検証 ∼切除を含む集学的治療の重要性∼, 第11回日本肝がん分子標的治療研究会, Jan. 2015.
664.	良元俊昭, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 石川大地, 吉川雅登 and 寺奥大貴 : ソラフェニブ投与後切除可能となり長期生存が得られたFGF4強発現進行肝細胞癌の症例, 第102回日本消化器病学会四国支部例会, Nov. 2014. (Keyword) 国内学会
665.	Eiji Takeda, Hisami Okumura, 和田宵湖, 山本もも, 杉原康平, Yuji Morine, Satoru Imura and Mitsuo Shimada : 中遊離脂肪酸(NEFA)濃度を指標とした就寝前夜食(LES)療法の適応, 第45回日本消化吸収学会総会, Nov. 2014.
666.	吉川雅登, Mitsuo Shimada, 寺奥大貴, Wubetu Gizchew Yismaw, 石川大地, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝細胞癌におけるSTAT4発現は腫瘍免疫を反映し予後因子となる, 第76回日本臨床外科学会総会, Nov. 2014. (Keyword) 国内学会
667.	寺奥大貴, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地 and 吉川雅登 : 肝細胞癌におけるLine1メチル化レベルは肝切除後予後因子となる, 第76回日本臨床外科学会総会, Nov. 2014. (Keyword) 国内学会
668.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Shin-ichiro Yamada, 石川大地, 吉川雅登 and 寺奥大貴 : 立体臓器モデルによる3D virtual hepatectomyと術中navigation systemを駆使した肝切除, 第76回日本臨床外科学会総会, Nov. 2014. (Keyword) 国内学会
669.	Tetsuya Ikemoto, Mitsuo Shimada, Yuji Morine, Satoru Imura, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 膵頭十二指腸切除術に対する取り組みと在院期間短縮についての検討, 第76回日本臨床外科学会総会, Nov. 2014. (Keyword) 国内学会
670.	Yuji Morine, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 石川大地, Jun Higashijima, Chie Takasu and Hidenori Miyake : 切除不能大腸癌肝転移に対する治療戦略, 第76回日本臨床外科学会総会, Nov. 2014. (Keyword) 国内学会
671.	Satoru Imura, 吉川雅登, 寺奥大貴, 石川大地, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Mitsuo Shimada : 若手肝臓外科医を育成するための取り組み∼3Dプリンターによる術中ナビゲーションと評価シートによるフィードバック∼, 第76回日本臨床外科学会総会, Nov. 2014. (Keyword) 国内学会
672.	Shin-ichiro Yamada, Mitsuo Shimada, 石川大地, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi and Yu Saitou : 肝細胞癌におけるSTAT4発現は細胞性免疫の制御に関与し予後因子となり得る, 第25回日本消化器癌発生学会総会, Nov. 2014. (Keyword) 国内学会
673.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, 吉川雅登 and 寺奥大貴 : Epigallocatechin gallateは安全性の高い新規抗腫瘍剤として有用である, 第25回日消化器癌発生学会総会, Nov. 2014. (Keyword) 国内学会
674.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Shin-ichiro Yamada, 石川大地, 吉川雅登 and 寺奥大貴 : 立体臓器モデルによる3D-virtual hepatectomyと術中navigation systemを用いた肝切除, 第23回日本コンピュータ外科学会, Nov. 2014. (Keyword) 国内学会
675.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 高齢者における肝再生不全の肝星細胞からのアプローチ, 第22回日本消化器関連学会週間(JDDW), Oct. 2014. (Keyword) 国内学会
676.	Satoru Imura, 石川大地, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Chie Takasu, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 根治性からみた進行肝癌初回治療法の選択, 第22回日本消化器関連学会週間(JDDW), Oct. 2014. (Keyword) 国内学会
677.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, 石川大地, 吉川雅登, 寺奥大貴 and Chie Takasu : 3mm細径鉗子を用いたReduced Port Lap-Cに関する検討, 第27回日本内視鏡外科学会総会, Oct. 2014. (Keyword) 国内学会
678.	Shin-ichiro Yamada, Gizachew Yismaw, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, 石川大地, 吉川雅登, 寺奥大貴 and Mitsuo Shimada : 分枝鎖アミノ酸はオートファジーを介してインスリン存在下の癌細胞増殖を抑制する, 第73回日本癌学会学術総会, Sep. 2014. (Keyword) 国内学会
679.	石川大地, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada, 寺奥大貴 and Gizachew Yismaw : 肝細胞癌におけるSTAT4発現は細胞性免疫の制御に関与し予後因子となり得る, 第73回日本癌学会学術総会, Sep. 2014. (Keyword) 国内学会
680.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Chie Takasu, 石川大地, 吉川雅登, 寺奥大貴 and Yismaw Gizachew : 安全な新規抗腫瘍剤としてのエピガロカテキンガレート, 第73回日本癌学会学術総会, Sep. 2014. (Keyword) 国内学会
681.	Tetsuya Ikemoto, Mitsuo Shimada, Satoru Imura, Yuji Morine, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 紫令湯による膵島破壊抑制機序の解明に関する免疫学的検討, 第50回日本移植学会総会, Sep. 2014. (Keyword) 国内学会
682.	Yu Saitou, 寺奥大貴, 吉川雅登, 石川大地, Shin-ichiro Yamada, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 肝星細胞からみた加齢肝再生不全の検討, 第50回日本移植学会総会, Sep. 2014. (Keyword) 国内学会
683.	Shuichi Iwahashi, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada and 石川大地 : RFA後肝細胞癌再発例においてEMT誘導を介し腫瘍悪性度が増強する, 第89回中国四国外科学会総会(第19回中国四国内視鏡外科研究会), Sep. 2014. (Keyword) 国内学会
684.	Yu Saitou, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, 石川大地, 寺奥大貴 and 吉川雅登 : 下右肝静脈温存，上右肝静脈とドレナージ領域を含む合理的拡大肝S8切除術, 第89回中国四国外科学会総会(第19回中国四国内視鏡外科研究会), Sep. 2014. (Keyword) 国内学会
685.	寺奥大貴, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 石川大地 and Chie Takasu : Epigallocatechin gallateは安全性の高い新規抗腫瘍剤として有用である, 第52回日本癌治療学会学術集会, Aug. 2014.
686.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 石川大地 and Jun Higashijima : 肝内胆管癌におけるFBXW7発現低下と臨床病理学的意義, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
687.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu and Jun Higashijima : 肝内胆管癌に対するGFP術後補助療法の有用性, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
688.	Satoru Imura, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Yusuke Arakawa, Jun Higashijima, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : ソラフェニブ投与後長期生存例の検証:切除を含む集学的治療の重要性, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
689.	吉川雅登, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Jun Higashijima : 肝細胞癌におけるサルコペニアと臨床病理学的意義, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
690.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and Shin-ichiro Yamada : MicroRNA-449a発現低下は大腸癌の腫瘍進展に関与し予後不良因子となる, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
691.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : RFA後肝細胞癌再発例においてはEMT誘導を介し腫瘍悪性度が増強する, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
692.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地, Jun Higashijima and Chie Takasu : 切除不能大腸癌肝転移に対する肝切除を基軸とした治療戦略, 第52回日本癌治療学会学術集会, Aug. 2014. (Keyword) 国内学会
693.	寺奥大貴, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and Yu Saitou : 肝細胞癌における顕微鏡的門脈浸潤(vp)予測因子の検討, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
694.	Shin-ichiro Yamada, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and Yu Saitou : RFA後肝細胞癌再発例においてEMT誘導を介し腫瘍悪性度が増強する-microRNA発現に着目して-, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
695.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : 肝細胞癌におけるSTAT4発現は腫瘍免疫を反映し予後因子となる, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
696.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Chie Takasu and Yu Saitou : 肝胆膵外科手術における周術期栄養評価方法としてのInBodyを用いた体組成分析の有用性に関する検討, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
697.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and Chie Takasu : 肝細胞癌におけるLine1 methylation statusは予後因子となる, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
698.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 安全性の高い新規抗腫瘍剤としてのEpigallocatechin gallate-癌幹細胞治療抵抗性解除をめざして-, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
699.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 80歳以上超高齢者における肝切除の妥当性に関する検討-肝星細胞に着目した加齢再生不全機序の解明-, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
700.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou and 石川大地 : 3D virtual imageと術中navigation systemがもたらした革新的画像技術を用いた安全な肝切除, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
701.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu and Hidenori Miyake : 切除不能転移性肝癌に対する"Early Conversion"を目指したFOLFOXILI療法の可能性, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
702.	Satoru Imura, 石川大地, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 肝切除を基軸とした進行肝癌にたいする集学的治療戦略, 第69回日本消化器外科学会, Jul. 2014. (Keyword) 国内学会
703.	吉川雅登, Mitsuo Shimada, 石川大地, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 予後不良因子を有する進行胆嚢癌における術後補助GFP療法の効果, 第39回日本外科系連合学会学術集会, Jul. 2014. (Keyword) 校内学会
704.	Shuichi Iwahashi, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Yu Saitou, Shin-ichiro Yamada and 石川大地 : RFA後肝細胞癌再発例はEMT誘導を介して腫瘍悪性度が増強する-RFA後肝細胞癌における肝移植適応に関して-, 第32回日本肝移植研究会, Jul. 2014. (Keyword) 国内学会
705.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Yu Saitou, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝星細胞からみた加齢肝再生不全の検討, 第32回日本肝移植研究会, Jul. 2014. (Keyword) 国内学会
706.	Chie Takasu, Satoru Imura, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : ソラフェニブ投与後長期生存例の検証, 第10回日本肝がん分子標的治療研究会, Jun. 2014. (Keyword) 国内学会
707.	良元俊昭, Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, 荒川悠介 and Shuichi Iwahashi : 術後14年を経過して腹膜藩種再発をきたしたSolid-pseudopap, 第39日本外科系連合学会, Jun. 2014. (Keyword) 国内学会
708.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 石川大地 : 3D virtual hepatectomyと術中navigation systemを用いた肝切除, 第39回日本外科系連合学会学術集会, Jun. 2014. (Keyword) 国内学会
709.	石川大地, Mitsuo Shimada, Shin-ichiro Yamada, Yu Saitou, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝細胞癌におけるSTAT4発現は細胞性免疫の制御に関与し予後因子となり得る, 第39回日本外科系連合学会学術集会, Jun. 2014. (Keyword) 国内学会
710.	Shin-ichiro Yamada, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 脂肪由来幹細胞(ADSCs)の膵島細胞保護作用にはIL-6ではなくVEGFシグナルが関与する, 第39回日本外科系連合学会学術集会, Jun. 2014. (Keyword) 国内学会
711.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : RFA後肝細胞癌再発例におけるEMT関連遺伝子発現の意義, 第39回日本外科系連合学会学術集会, Jun. 2014. (Keyword) 国内学会
712.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Yusuke Arakawa, Yu Saitou, Shuichi Iwahashi, Shin-ichiro Yamada and 石川大地 : Celiac axis compression syndromeにより術後管理に難渋して膵頭十二指腸切除術, 第39回日本外科系連合学会学術集会, Jun. 2014. (Keyword) 国内学会
713.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 肝細胞癌切除症例におけるRFAの影響-EMTマーカー発現に着目して-, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
714.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, Chie Takasu and Yu Saitou : InBodyを用いた体組成分析の肝胆膵外科手術における周術期栄養評価の有用性に関する検討, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
715.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : pT2胆嚢癌術後における予後不良因子陽性例に対する術後GFP療法の有用性, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
716.	池本哲也, 島田光生, 宇都宮徹, Yuji Morine, 居村暁, 荒川悠佑, 金本真美, 岩橋衆一, 齋藤裕 and 石川大地 : Notch signal発現がIPMNのEMT増強におよぼす治療成績に関する検討, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
717.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 切除不能転移性肝癌に対する"Early Conversion"を目指したFOLFOKILI療法の可能性, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
718.	Satoru Imura, 石川大地, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 3D virtual image とNavigation systemがもたらした革新的画像技術を駆使した肝切除, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
719.	Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 肝内胆管癌に対する系統系リンパ節郭清の意義と術後補助療法の効果, 第26回日本肝胆膵外科学会学術集会, Jun. 2014. (Keyword) 国内学会
720.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Shin-ichiro Yamada and 石川大地 : 80歳以上超高齢者における肝切除の妥当性に関する検討-術前栄養評価から見た高齢者の特徴-, 第26回日本肝胆膵外科学科学術集会, Jun. 2014. (Keyword) 国内学会
721.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 石川大地 : RFA後肝細胞癌再発例においてEMT誘導wp介し腫瘍悪性度が増強する-microRNA発現に着目して-, 第50回日本肝癌研究会, Jun. 2014. (Keyword) 国内学会
722.	Yusuke Arakawa, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi and 石川大地 : 肝内胆管癌に対する系統的リンパ節郭清の意義と術後補助療法の効果, 第50回日本肝癌研究会, Jun. 2014. (Keyword) 国内学会
723.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 切除不能転移性肝癌に対する"Early Conversion"を目指したFOLFOXILI療法の可能性, 第50回日本肝癌研究会, Jun. 2014. (Keyword) 国内学会
724.	Satoru Imura, Yu Saitou, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : ソラフェニブ投与後長期生存例の検証:切除を含む集学的治療の重要性, 第50回日本肝癌研究会, Jun. 2014. (Keyword) 国内学会
725.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 徳島県におけるより円滑な地域連携・病診連携推進のための活動について, 第50回日本肝臓学会総会, May 2014. (Keyword) 国内学会
726.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 肝星細胞による加齢肝再生不全機序の検討, 第50回日本肝臓学会総会, May 2014. (Keyword) 国内学会
727.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Shin-ichiro Yamada : 肝細胞癌におけるSTAT4発現は細胞性免疫の制御に関与し予後因子となり得る, 第50回日本肝臓学会総会, May 2014. (Keyword) 国内学会
728.	Satoru Imura, 石川大地, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 局所再発させない適確な症例選択がRFA成績向上につながる∼組織学的門脈浸潤(vp)陽性肝癌を予測し，RFA適応外へ∼, 第50回日本肝臓学会総会, May 2014. (Keyword) 国内学会
729.	Yu Saitou, 寺奥大貴, 吉川雅登, 石川大地, Shin-ichiro Yamada, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mitsuo Shimada : 高齢者の肝再生不全の機序解明と治療への応用, 第40回日本急性肝不全研究会, May 2014. (Keyword) 国内学会
730.	Hiroki Ishibashi, Hiroki Mori, Mitsuo Shimada and Yuji Morine : 小児膵・胆管合流異常における共通管拡張・非拡張別の臨床像について―合流異常研究会登録症例の解析―, 第51回日本小児外科学会学術集会, May 2014. (Keyword) 国内学会
731.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Chie Takasu and 石川大地 : HCCRFA治療後にリンパ節転移再発を繰り返す症例, 第100回日本消化器病学会総会, Apr. 2014. (Keyword) 国内学会
732.	吉川雅登, Mitsuo Shimada, 石川大地, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 若手外科医のための膵頭十二指腸切除における術前3Dsimulationの有用性, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
733.	寺奥大貴, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 進行胆嚢癌の予後因子と術後補助GFP療法の効果, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
734.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 肝星細胞からみた加齢肝再生不全の検討, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
735.	Shin-ichiro Yamada, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 肝細胞癌切除症例に対するRFAの影響(第2報)-RFA後肝細胞癌再発例はEMT誘導を介して予後不良となる-, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
736.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, 石川大地, Shin-ichiro Yamada, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 脂肪由来幹細胞の細胞保護効果には臓器特異性がある, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
737.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 癌肝細胞治療抵抗性にEpigenetic修飾が関与する(第2報)-Methylation statusと遺伝子発現の変化に着目して-, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
738.	石川大地, Mitsuo Shimada, Chie Takasu, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 肝細胞癌におけるSTAT4発現は細胞性免疫の制御に関与し予後因子となり得る, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
739.	Mami Kanamoto, Yasuhiro Hamada, Yutaka Nakaya, Eiji Takeda, Hisami Okumura, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori and Mitsuo Shimada : NST介入による周術期栄養管理の有用性に関する検討, 第114回日本外科学会定期学術集会, Apr. 2014.
740.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 大腸癌肝転移のconversion surgeryを目指した治療戦略, 第114回日本外科学会定期学術集会, Apr. 2014. (Keyword) 国内学会
741.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 石川大地 : 柴令湯による膵島破壊抑制機序の解明に関する研究, 第114回日本外科学会定期学術集会, Apr. 2014.
742.	Toru Utsunomiya, Mitsuo Shimada, 石川大地, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Chie Takasu : Role of epigenetic modulation in both tumor and non-tumor liver tissues on risk of recurrence after hepatectomy for hepatocellular carcinoma: A possible implication for personalized medicine, 第114回日本外科学会定期学術集会, Apr. 2014.
743.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 癌幹細胞治療抵抗性におけるEpigenetic修飾の関与-Methylation statusの変化に着目して-, 第47回制癌剤適応研究会, Mar. 2014. (Keyword) 国内学会
744.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Shin-ichiro Yamada and 石川大地 : 紫令湯による糖尿病発症マウスの膵島破壊抑制機序の免疫学的検討, 第41回日本膵・膵島移植研究会, Mar. 2014. (Keyword) 国内学会
745.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 癌肝細胞治療抵抗性におけるEpigenetic修飾の関与―Methylation statusの変化に着目して―, 第47回制癌剤適応研究会, Mar. 2014.
746.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎 and 石川大地 : 紫令湯による糖尿病発症マウスの膵島破壊抑制機序の免疫学的検討, 第41回日本膵・膵島移植研究会, Mar. 2014.
747.	宮崎克己, Mitsuo Shimada, Tetsuya Ikemoto, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地 and Hidenori Miyake : 経皮的ラジオ波焼灼療法による遅発生横隔膜ヘルニア篏頓(横行結腸)の1例, 第50回日本腹部救急医学会, Mar. 2014. (Keyword) 国内学会
748.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 膵切除後腹腔内出血に対するIVRに関する検討, 第50回日本腹部救急医学会, Mar. 2014. (Keyword) 国内学会
749.	宮崎克己, Mitsuo Shimada, Tetsuya Ikemoto, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地 and Hidenori Miyake : 経皮的ラジオ波焼灼療法による遅発生横隔膜ヘルニア篏頓(横行結腸)の1例, 第50回日本腹部救急医学会, Mar. 2014.
750.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 膵切除後腹腔内出血に対するIVRに関する検討, 第50回日本腹部救急医学会, Mar. 2014.
751.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Shin-ichiro Yamada, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 高齢者に対する肝切除後の肝再生不全の機序解明とその対策:ベッドサイからベンチへのアプローチ, 第248回徳島医学会学術集会(平成25年度冬期), Feb. 2014. (Keyword) 国内学会
752.	石川大地, Mitsuo Shimada, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 肝細胞癌におけるSTAT4発現は細胞性免疫の制御に関与し予後因子となり得る, 第248回徳島医学会学術集会(平成25年度冬期), Feb. 2014. (Keyword) 国内学会
753.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 高齢者に対する肝切除後の肝再生不全の機序解明とその対策:ベッドサイドからベンチへのアプローチ, 第248回徳島医学会学術集会, Feb. 2014.
754.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, Shin-ichiro Yamada, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 進行肝細胞癌に対するソラフェニブと外科治療を組み合わせた治療成績, 第9回日本肝がん分子標的治療研究会, Jan. 2014. (Keyword) 国内学会
755.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 進行肝細胞癌に対するソラフェニブと外科治療を組み合わせた治療成績, 第9回日本肝がん分子標的治療研究会, Jan. 2014.
756.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, 石川大地, 山田眞一郎, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Chie Takasu and Hidenori Miyake : 脂肪由来幹細胞の細胞保護効果には臓器特異性がある, 第20回外科侵襲とサイトカイン研究会, Dec. 2013.
757.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, Yu Saitou and 石川大地 : Vessel sealing systemを用いた肝嚢胞に対する単孔式腹腔鏡下嚢胞開窓術の有用性, 第26回日本内視鏡外科学会総会, Nov. 2013.
758.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地 and Hidenori Miyake : 肝細胞癌における短期・長期予後から見た鏡視下手術の妥当性, 第26回日本内視鏡外科学会総会, Nov. 2013.
759.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 石川大地 and Chie Takasu : 3D virtual hepatectomyと術中navigation systemを用いた肝切除, 第26回日本内視鏡外科学会総会, Nov. 2013.
760.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Kouzou Yoshikawa, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 肝胆膵外科領域における漢方製剤使用が周術期管理に与える影響に関する検討, 第23回外科漢方研究会学術集会, Nov. 2013.
761.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Kouzou Yoshikawa, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 肝癌切除術施行後における臨床的な役割, 第23回外科漢方研究会学術集会, Nov. 2013.
762.	石川大地, Mitsuo Shimada, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : IPMNにおける梢血調節性T細胞比率による術前悪性度予測と上皮間葉転換, 第75回日本臨床外科学会総会, Nov. 2013.
763.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地, Chie Takasu and Hidenori Miyake : 予後不良因子を有する進行胆嚢癌における術後補助GFP療法の効果, 第75回日本臨床外科学会総会, Nov. 2013.
764.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地 and Hidenori Miyake : Borderline resectable膵癌に対する治療成績の検討, 第75回日本臨床外科学会総会, Nov. 2013.
765.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地 and Hidenori Miyake : 肝癌切除例からみた日本に適したステージ分類∼取り扱い規約とUICCの比較から∼, 第75回日本臨床外科学会総会, Nov. 2013.
766.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, 石川大地, 楠本彩子 and Hidenori Miyake : 徳島県における肝疾患診療連携ネットワークについて, 第75回日本臨床外科学会総会, Nov. 2013.
767.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, Horohiko Sato and Hidenori Miyake : 胆道癌切除例における術後補助GFP療法及び，再発症例に対する再肝切除の有用性, 第75回日本臨床外科学会総会, Nov. 2013.
768.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 石川大地 and Hidenori Miyake : 大腸癌肝転移のconversion surgeryを目指した治療戦略, 第75回日本臨床外科学会総会, Nov. 2013.
769.	Toru Utsunomiya, Mitsuo Shimada, 石川大地, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 高度進行肝癌に対する治療戦略―術後補助IFP療法およびソラフェニブ・手術併用の有用性―, 第75回日本臨床外科学会総会, Nov. 2013.
770.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, 山田眞一郎, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 石川大地 : 80歳以上超高齢者における肝切・PDの妥当性に関する検討, 第75回日本臨床外科学会総会, Nov. 2013.
771.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 石川大地 : 術中ヒヤリハットから得た教訓に基づくStep by stepでの手技工夫, 第7回肝臓内視鏡外科研究会, Nov. 2013.
772.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Chie Takasu, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 高齢者の肝再生不全の機序解明と治療への応用, 第43回日本創傷治癒学会, Nov. 2013.
773.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, 山田眞一郎, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 石川大地 and Chie Takasu : 超高齢者における肝胆膵手術の妥当性に関する検討―癌根治によるQOL向上を目指して―, 第51回日本癌治療学会学術集会, Oct. 2013.
774.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, Yu Saitou, Chie Takasu, 石川大地 and Hidenori Miyake : 徳島県における肝癌診療連携ネットワークについて, 第51回日本癌治療学会学術集会, Oct. 2013.
775.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地 and Hidenori Miyake : IPMNにおける悪性度予想に関するバイオマーカーとしてのEMT関連因子, 第51回日本癌治療学会学術集会, Oct. 2013.
776.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Chie Takasu, 山田眞一郎 and Hidenori Miyake : 進行肝癌に対するソラフェニブの治療成績―Conversionできた著効例の検討とあわせて―, 第51回日本癌治療学会学術集会, Oct. 2013.
777.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地, Chie Takasu and Hidenori Miyake : 大腸癌肝転移に対する治療戦略―外科切除の適応とconversion surgery―, 第51回日本癌治療学会学術集会, Oct. 2013.
778.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Shuichi Iwahashi and Toru Utsunomiya : 進行肝細胞癌に対するソラフェニブと外科治療を組み合わせた治療成績, JDDW 2013 第21回日本消化器関連学会週間, Oct. 2013.
779.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Hiroki Mori, 矢田圭吾 and Hidenori Miyake : IPMNにおけるTwist1，Bmi1発現に関する検討, 第72回日本癌学会学術総会, Oct. 2013.
780.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou and 石川大地 : 癌幹細胞の治療抵抗性獲得におけるepigenetic修飾の意義, 第72回日本癌学会学術総会, Oct. 2013.
781.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, 山田眞一郎, Yuji Morine, Satoru Imura, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Chie Takasu and 浅野間理仁 : 脂肪由来幹細胞の傷害肝へのホーミング効果―癌幹細胞転移メカニズムへの応用―, 第72回日本癌学会学術総会, Oct. 2013.
782.	Toru Utsunomiya, Yu Saitou, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地, Atsushi Tajima and Issei Imoto : ゲノムワイドなDNAメチル化解析に基づく非B非C肝癌例の非癌部肝組織におけるDNAメチル化異常の特徴, 第72回日本癌学会学術総会, Oct. 2013.
783.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 石川大地 : 3D virtual hepatectomyと術中navigation systemを用いた肝切除, 第8回肝癌治療シミュレーション研究会, Sep. 2013.
784.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi, 矢田圭吾, 山田眞一郎, 石川大地, Chie Takasu and Hidenori Miyake : 膵・胆管合流異常症例における胆道癌発癌機構に関する研究, 第49回日本胆道学会学術集会, Sep. 2013.
785.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and Hidenori Miyake : Stem cell markerに着目した細胆管癌の悪性度に関する検討(肝内胆管癌との比較より), 第49回日本胆道学会学術集会, Sep. 2013.
786.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : 3Dvirtual hepatectomyと術中navigation systemを用いた肝切除, 第22回日本コンピュータ外科学会, Sep. 2013.
787.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Chie Takasu, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : ラットsmall-for-size graft modelにおける脾臓内遺伝子発現の変化Ingenuity Pathway Analysisを用いた検討, 第49回日本移植学会総会, Sep. 2013.
788.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎 and Chie Takasu : 脂肪由来幹細胞を用いた膵島移植成績向上に関する展望と課題, 第49回日本移植学会総会, Sep. 2013.
789.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎 and Hidenori Miyake : C型肝硬変に対するABO不適合肝移植後の低用量Peg-IFN/RBV療法の有用性, 第49回日本移植学会総会, Sep. 2013.
790.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, 山田眞一郎, 石川大地, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Hiroki Mori, Yuji Morine and Satoru Imura : ヒト脂肪由来幹細胞による肝傷害軽減効果に関する基礎的検討, 第49回日本移植学会総会, Sep. 2013.
791.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Hidenori Miyake : IPMNにおけるTwist1，Bmi1発現の意義, 第24回日本消化器癌発生学会総会, Sep. 2013.
792.	Toru Utsunomiya, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝細胞癌の癌部と非癌部の両方におけるFbxw7高発現は術後再発の独立危険因子である, 第24回日本消化器癌発生学会総会, Sep. 2013.
793.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : 集学的治療により長期生存がえられた生体肝移植後肝細胞再発症例, 第31回中国四国臓器移植研究会, Aug. 2013.
794.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto and Shuichi Iwahashi : Vessel sealing systemを用いた肝嚢胞に対する単孔式内視鏡手術, 2nd Reduced Port Surgery Forum 第9回 Needlescopic Surgery meeting/第7回単孔式内視鏡手術研究会, Aug. 2013.
795.	Hiroki Mori, Mitsuo Shimada, Hiroki Ishibashi, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Shuichi Iwahashi : 膵・胆管合流異常症に対する長期経過中に胆道癌を合併した3症例の検討, 第68回日本消化器外科学会総会, Jul. 2013.
796.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and Chie Takasu : 徳島県の施設アンケートから見た膵島移植候補患者の現状と問題点, 第68回日本消化器外科学会総会, Jul. 2013.
797.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and Chie Takasu : IPMNにおける抹消血調節性T細胞比率とEMT誘導に関する検討, 第68回日本消化器外科学会総会, Jul. 2013.
798.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎 and 石川大地 : 肝細胞癌切除症例に対するRFAの影響―遺伝子発現に着目した機序解明へのアプローチ―, 第68回日本消化器外科学会総会, Jul. 2013.
799.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, 佐々木一, 青沼広光 and 川島昭浩 : 肝癌に対する肝切除周術期生体侵襲におけるWhey protein含有高機能, 第68回日本消化器外科学会総会, Jul. 2013.
800.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Chie Takasu and Hidenori Miyake : 部分肝機能を考慮した新たな肝切除シミュレーションの展開, 第68回日本消化器外科学会総会, Jul. 2013.
801.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : 安全・確実な肝葉切除のポイント―術前・術中ナビゲーションと出血制御テクニック―, 第68回日本消化器外科学会総会, Jul. 2013.
802.	Toru Utsunomiya, Mitsuo Shimada, Chie Takasu, 山田眞一郎, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝細胞癌の術後再発リスク予測には癌部と非癌部のバイオマーカー(Fbxw7)評価が必要である, 第68回日本消化器外科学会総会, Jul. 2013.
803.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, 山田眞一郎, 矢田圭吾 and 石川大地 : 症例, 第49回日本肝癌研究会, Jul. 2013.
804.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Yu Saitou, 山田眞一郎, 石川大地 and Hidenori Miyake : 右側肝円策をと伴う肝門部胆管癌切除例からみた肝区域分類の把握, 第49回日本肝癌研究会, Jul. 2013.
805.	石川大地, Mitsuo Shimada, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 肝細胞癌の癌部・非癌部における細胞周期調節因子Fbxw7の発現低下は独立予後規定因子である, 第49回日本肝癌研究会, Jul. 2013.
806.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : 肝内胆管癌に対する系統的リンパ節郭清の意義と術後補助療法の効果, 第49回日本肝癌研究会, Jul. 2013.
807.	Satoru Imura, 石川大地, 浅野間理仁, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 肝細胞癌における顕微鏡的門脈浸潤(vp)予測因子の検討∼RFAが好ましくない肝癌の特徴∼, 第49回日本肝癌研究会, Jul. 2013.
808.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi and 山田眞一郎 : ABO不適合およびドナー特異的抗HLA抗体陽性のレシピエントに対する生体肝移植の成功例, 第31回日本肝移植研究会, Jul. 2013.
809.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, 浅野間理仁, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 高齢ドナー肝再生不全と加齢指標マーカーについての検討, 第31回日本肝移植研究会, Jul. 2013.
810.	Satoru Imura, 石川大地, 浅野間理仁, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Takashi Iwata, Toru Utsunomiya and Mitsuo Shimada : 脳死肝移植推進のための医学生への啓蒙活動の必要性∼ドナーアクションの一環としての取り組み∼, 第31回日本肝移植研究会, Jul. 2013.
811.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and Hidenori Miyake : IPMNにおけるEMT関連因子(Twist1, Bmi1)発現の意義についての検討, 第99回日本消化器病学会四国支部例会/第110回日本消化器内視鏡学会四国支部例会, Jun. 2013.
812.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 高齢ドナー肝再生不全と加齢指標マーカーについての検討, 第99回日本消化器病学会四国支部例会/第110回日本消化器内視鏡学会四国支部例会, Jun. 2013.
813.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, Horohiko Sato and Hidenori Miyake : IPMNにおけるEMT関連因子(Twist1,Bmi1)発現の意義についての検討, 第22回日本癌病態治療研究会, Jun. 2013.
814.	吉川雅登, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : ミラノ基準内の肝細胞癌に対する肝切除治療成績に関する検討∼亜区域切除と部分切除の比較∼, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
815.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 山田眞一郎 : 大腸癌肝転移症例に対する腹腔鏡下同時切除の有用性に関する検討, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
816.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 浅野間理仁, Chie Takasu and Hidenori Miyake : 癌幹細胞の治療抵抗性獲得と解除におけるEpigenetic修飾の関与, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
817.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : Inbodyを用いた体成分分析と膵臓手術周術期における栄養評価に関する検討, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
818.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, 浅野間理仁, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Toru Utsunomiya, Hidenori Miyake and Chie Takasu : 当科における非B非C型初発肝細胞癌切除症例の検討, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
819.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou and 山田眞一郎 : 膵IPMNにおけるNotch signallは調節性T細胞expansionおよび腫瘍EMTを増強する, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
820.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 石川大地 and Hidenori Miyake : 大腸癌肝転移に対する治療戦略―外科切除の適応とconversion surgery―, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
821.	Toru Utsunomiya, Mitsuo Shimada, 石川大地, 山田眞一郎, 浅野間理仁, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝門部脈管fusion画像と部分肝機能評価を取り入れた新たな肝切除術前シミュレーションの有用性, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
822.	Yu Saitou, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 石川大地 and Hidenori Miyake : 安全・確実な肝葉切除のポイント―肝離断における出血制御テクニック―, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
823.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 手技定型化による安全確実な肝葉切除術, 第25回日本肝胆膵外科学会・学術集会, Jun. 2013.
824.	Mami Kanamoto, Mitsuo Shimada, Yutaka Nakaya, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎, 石川大地 and Hidenori Miyake : Inbodyを用いた体成分分析と膵臓手術周術期における栄養評価に関する検討, 第38回日本外科系連合学会学術集会, Jun. 2013.
825.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 浅野間理仁, 石川大地 and Hidenori Miyake : 肝細胞癌切除例に対するRFAの影響, 第49回日本肝臓学会総会, Jun. 2013.
826.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁, 石川大地 and Hidenori Miyake : 分子標薬的Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善・肝再生促進効果, 第49回日本肝臓学会総会, Jun. 2013.
827.	矢田圭吾, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁, 石川大地 and Hidenori Miyake : Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善・肝再生促進効果, 第113回日本外科学会定期学術集会, Apr. 2013.
828.	高田厚史, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁, Toru Utsunomiya and Hidenori Miyake : 右側肝円索を伴う肝門部胆管癌からみた肝区域分類の把握, 第113回日本外科学会定期学術集会, Apr. 2013.
829.	吉川雅登, 山田眞一郎, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 浅野間理仁, 石川大地 and Hidenori Miyake : IPMNにおけるPKCiota発現の意義に関する研究, 第113回日本外科学会定期学術集会, Apr. 2013.
830.	寺奥大貴, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁, Toru Utsunomiya and Hidenori Miyake : 肝内胆管癌におけるEMT関連遺伝子発現, 第113回日本外科学会定期学術集会, Apr. 2013.
831.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 浅野間理仁, 山田眞一郎, Horohiko Sato and Hidenori Miyake : IPMNにおけるEMT関連因子(Twist1, Bmi1)発現の意義についての検討, 第113回日本外科学会定期学術集会, Apr. 2013.
832.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 浅野間理仁 and 石川大地 : 肝硬変における脾臓の役割と脾摘の有用性, 第113回日本外科学会定期学術集会, Apr. 2013.
833.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 山田眞一郎 : 脾臓内サイトカイン発現が肝硬変合併肝癌に関与する, 第113回日本外科学会定期学術集会, Apr. 2013.
834.	Yu Saitou, Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 浅野間理仁, 石川大地 and Hidenori Miyake : 肝発癌母地に着目した肝細胞癌の治療戦略―DNA, miRNA, Methylationアレイを用いた非癌部肝組織の解析より―, 第113回日本外科学会定期学術集会, Apr. 2013.
835.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 浅野間理仁, 石川大地 and Hidenori Miyake : 癌幹細胞の治療抵抗性獲得と喪失にepigenetic修飾が関与している, 第113回日本外科学会定期学術集会, Apr. 2013.
836.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Horohiko Sato, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : Whey protein含有高機能流動食を用いた周術期栄養療法の有用性, 第113回日本外科学会定期学術集会, Apr. 2013.
837.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 矢田圭吾 : 胆道癌発がんモデルの膵・胆管合流異常症での発がん特性の解析, 第113回日本外科学会定期学術集会, Apr. 2013.
838.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, 浅野間理仁, Yu Saitou, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 高齢者の肝再生不全の機序解明と治療への応用, 第113回日本外科学会定期学術集会, Apr. 2013.
839.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Yu Saitou, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 脂肪由来幹細胞を用いた肝胆膵領域の再生医療に関するimpactと課題, 第113回日本外科学会定期学術集会, Apr. 2013.
840.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 浅野間理仁, 山田眞一郎, 石川大地 and Hidenori Miyake : 上右肝静脈ドレナージ領域切除を伴う拡大前区域切除術∼虚血域と鬱血域を残さない合理的な肝切除∼, 第113回日本外科学会定期学術集会, Apr. 2013.
841.	Yuji Morine and Mitsuo Shimada : 肝内胆管癌のリンパ節郭清の意義〈意義あり vs. 意義なし〉 <意義なし>, 第113回日本外科学会定期学術集会, Apr. 2013.
842.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : NSTによる栄養管理によってQOLと臨床症状の改善を図った糖尿病合併肝硬変の一例, 第15回四国肝不全研究会, Apr. 2013.
843.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁, 山田眞一郎, Horohiko Sato and Hidenori Miyake : EMT関連因子はIPMNの悪性度，予後に関与する, 第99回日本消化器病学会総会, Mar. 2013. (Keyword) 国内学会
844.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 石川大地 : 原発性肝癌における短期・長期予後から見た鏡視下手術の妥当性, 第25回日本内視鏡外科学会総会, Dec. 2012. (Keyword) 国内学会
845.	Yuji Morine, Shuichi Iwahashi and 島田光生 : 癌幹細胞の治療抵抗性獲得と解除におけるepigenetic修飾の関与, 第99回日本消化器病学会総会, Dec. 2012. (Keyword) 国内学会
846.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 淺野間理仁 : 癌幹細胞の治療抵抗性獲得と解除におけるEpigenetic修飾の関与, 第246回徳島医学会学術集会, Dec. 2012. (Keyword) 国内学会
847.	寺奥大貴, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 淺野間理仁 and 石川大地 : 腹腔内出血に苦しんだ膵体尾部癌の1切除例, 第21回徳島外科術後管理研究会, Dec. 2012. (Keyword) 国内学会
848.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 淺野間理仁 and 石川大地 : 脂肪由来幹細胞(ADSC)の膵島細胞保護作用には，VEGFシグナルが関与する, 第19回外科侵襲とサイトカイン研究会, Dec. 2012. (Keyword) 国内学会
849.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地 and Hidenori Miyake : Bevacizumabの小胞体ストレス応答を介した大量切除後肝機能障害改善・肝再生促進効果, 第19回外科侵襲とサイトカイン研究会, Dec. 2012. (Keyword) 国内学会
850.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 2mm細径鉗子を用いたHybrid SILS-Cに関する検討, 第25回日本内視鏡外科学会総会, Dec. 2012. (Keyword) 国内学会
851.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and 石川大地 : 部分肝機能解析を取り入れた肝切除シミュレーション, 第25回日本内視鏡外科学会総会, Dec. 2012. (Keyword) 国内学会
852.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Horohiko Sato, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : DSA-HLA抗体陽性のレシピエントに対する生体肝移植の治療戦略, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
853.	石川大地, チンボルトエンヘボルト, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 山田眞一郎 : 肝切除前3Dシミュレーション画像による肝動脈，門脈，胆管の同時評価に関する検討, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
854.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, 淺野間理仁, 山田眞一郎, 矢田圭吾 and 石川大地 : 慢性性血液透析患者の肝癌に対する肝切除術の検討, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
855.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 石川大地 : 80歳以上超高齢者における肝切除，膵頭十二指腸切除の妥当性に関する検討, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
856.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 淺野間理仁, 山田眞一郎, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 高度門脈侵襲陽性の進行肝細胞癌に対する集学的治療戦略, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
857.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 淺野間理仁 : 2㎜細径鉗子を用いたHybrid SILS-Cに関する検討, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
858.	Toru Utsunomiya, Mitsuo Shimada, 石川大地, 淺野間理仁, 山田眞一郎, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 膵頭十二指腸切除術における輸血率ゼロのための工夫―郭清操作へのエネルギーデバイス導入による出血量軽減効果―, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
859.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, 山田眞一郎, 淺野間理仁, 石川大地 and Hidenori Miyake : IPMN手術適応判定における分子マーカーの検討―NotchシグナルはIPMN手術適応判定に有用である―, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
860.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi, 淺野間理仁, 山田眞一郎, 矢田圭吾 and 石川大地 : 日本における女性外科医の抱える問題点と対策∼スウェーデン留学の経験から, 第74回日本臨床外科学会総会, Nov. 2012. (Keyword) 国内学会
861.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Shuichi Iwahashi and 山田眞一郎 : Vessel sealing systemを用いた肝嚢胞に対する外科的治療, 第6回肝臓内視鏡外科研究会, Nov. 2012. (Keyword) 国内学会
862.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 淺野間理仁 : 肝細胞癌における短期・長期予後から見た鏡視下手術の妥当性, 第6回肝臓内視鏡外科研究会, Nov. 2012. (Keyword) 国内学会
863.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 幹細胞マーカーに着目した細胆管癌の悪性度に関する検討―肝内胆管癌との比較より―, 第23回日本消化器癌発生学会, Nov. 2012. (Keyword) 国内学会
864.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, 淺野間理仁, 齋藤裕, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 非癌部肝組織における小胞体ストレスマーカーの肝癌再発への関与, 第23回日本消化器癌発生学会, Nov. 2012. (Keyword) 国内学会
865.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 癌幹細胞の治療抵抗性獲得と解除におけるepigenetic修飾の関与, 第23回日本消化器癌発生学会, Nov. 2012. (Keyword) 国内学会
866.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 淺野間理仁 : 肝切除支援ソフトによる術前シミュレーション，術中ナビゲーション，部分肝臓機能解析, 第21回日本コンピュータ外科学会大会, Nov. 2012. (Keyword) 国内学会
867.	Tomohiko Miyatani, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 分子標的薬Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善効果, 第54回日本消化器病学会大会, Oct. 2012. (Keyword) 国内学会
868.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁, 山田眞一郎 and Horohiko Sato : IPMNにおけるProtein Kinase Ciota発現の意義, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
869.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Horohiko Sato, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 肝内胆管癌と比較した細胆管細胞癌の悪性度に関する検討, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
870.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and Horohiko Sato : 高度進行膵癌に対する治療戦略∼Sytemic GFP療法, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
871.	Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地 and Horohiko Sato : 非癌部肝組織におけるmiR-494およびPTEN発現の臨床病理学的意義, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
872.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Horohiko Sato, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎 and 石川大地 : 肝硬変合併肝癌における脾臓の役割, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
873.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, 淺野間理仁, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Horohiko Sato, Toru Utsunomiya and Hidenori Miyake : 非癌部肝組織における小胞体ストレスマーカーの肝癌再発への関与, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
874.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地 and Hidenori Miyake : 膵胆管合流異常症におけるepigenetic/genetic修飾を介した胆道癌発癌機構に関する検討, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
875.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 石川大地 : 大腸癌肝転移におけるSDF-1/CXCR4 axisの影響に関する研究, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
876.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Horohiko Sato, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Shuichi Iwahashi, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 肝癌に対する肝切除周術期生体侵襲におけるWhey protein含有高機能流動食投与の検討, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
877.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地, Horohiko Sato and Hidenori Miyake : 胆道癌切除例に対するGFP補助療法と再発肝切除導入効果の検証, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
878.	Toru Utsunomiya, Mitsuo Shimada, Tetsuya Ikemoto, Satoru Imura, 山田眞一郎, 淺野間理仁, Yuji Morine, 齋藤裕, Hiroki Mori and Mami Kanamoto : 若手への``完全相伝式''肝葉切除伝承への工夫:無輸血・胆汁瘻ゼロを目指して, JDDW, Oct. 2012. (Keyword) 国内学会
879.	Yuji Morine, Mitsuo Shimada and Mami Kanamoto : 肝癌における幹細胞マーカーの意義の再認識治療抵抗性克服への戦略, JDDW, Oct. 2012. (Keyword) 国内学会
880.	Yusuke Arakawa, Mitsuo Shimada, 石川大地, 山田眞一郎, 淺野間理仁, Shuichi Iwahashi, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 下右肝静脈温存，上右肝静脈及びドレナージ領域を含む合理的拡大肝前区域切除術, 第7回肝癌治療シミュレーション研究会, Oct. 2012. (Keyword) 国内学会
881.	矢田圭吾, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地 and Hiroki Ishibashi : 膵・胆管合流異常症に胆道癌を合併した3症例についての検討, 第50回日本癌治療学会学術集会, Oct. 2012. (Keyword) 国内学会
882.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, 山田眞一郎 and 淺野間理仁 : 生体肝移植レシピエント術後肝障害に対するWhey protein含有高機能流動食を用いた周術期栄養療法の有用性, 第48回日本移植学会総会, Sep. 2012. (Keyword) 国内学会
883.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, Horohiko Sato and Hidenori Miyake : ドナー特異的抗HLA抗体陽性のレシピエントに対する生体肝移植, 第48回日本移植学会総会, Sep. 2012. (Keyword) 国内学会
884.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 石川大地 : 脂肪由来幹細胞(ADSC)の膵島細胞保護作用には，IL-6シグナルは関与しない, 第48回日本移植学会総会, Sep. 2012. (Keyword) 国内学会
885.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 松本慎一, B Naziruddin and M.F. Levy : 自家膵島移植におけるInstant blood-mediated inflammatory reaction発現の検討, 第48回日本移植学会総会, Sep. 2012. (Keyword) 国内学会
886.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto and Munehide Matsuhisa : 四国地区モデルとしての徳島県の膵島移植待機患者の現状と問題点, 第48回日本移植学会総会, Sep. 2012. (Keyword) 国内学会
887.	山田眞一郎, Mitsuo Shimada, Yuji Morine, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto and Shuichi Iwahashi : 胆嚢摘出術後に胆管癌を発症した胆管非拡張型膵・胆管合流異常の2症例についての検討, 第48回日本胆道学会学術集会, Sep. 2012. (Keyword) 国内学会
888.	Hiroki Mori, Hiroki Ishibashi, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁, 山田眞一郎, Hidenori Miyake and Mitsuo Shimada : Risk of carcinogenesis in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation., 第71回日本癌学会学術総会, Sep. 2012.
889.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Mami Kanamoto, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : Tumor microenvironment is regulated by tumor Jagged 1 through Indoleamine 2, 3-dioxygenase(IDO) positive dendtric cell., 第71回日本癌学会学術総会, Sep. 2012. (Keyword) 国内学会
890.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Mami Kanamoto, 山田眞一郎, 淺野間理仁, 石川大地 and Hidenori Miyake : 分枝型IPMNの手術適応判定―分子生物学的マーカーによる評価―, 第87回中国四国外科学会総会, Sep. 2012. (Keyword) 国内学会
891.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 石川大地 : 胆嚢摘出後に胆管癌を発症した胆管非拡張型膵・胆管合流異常の2症例についての検討, 第35回日本膵・胆管合流異常研究会, Sep. 2012. (Keyword) 国内学会
892.	矢田圭吾, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁, 石川大地 and Hidenori Miyake : 非拡張型膵・胆管合流異常症の胆道上皮は発癌ポテンシャルを有する, 第35回日本膵・胆管合流異常研究会, Sep. 2012. (Keyword) 国内学会
893.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : ドナー特異的抗HLA抗体陽性のレシピエントに対する生体肝移植の1例, 第30回中国四国臨床臓器移植研究会, Aug. 2012. (Keyword) 国内学会
894.	Tomohiko Miyatani, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto and Hidenori Miyake : Conversionと化療の肝障害軽減を目指した治療戦略, 第67回日本消化器外科学会総会, Jul. 2012.
895.	石川大地, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto and 山田眞一郎 : Protein Kinase Cι発現はIPMNの新たな予後予測因子となる, 第245回徳島医学会学術集会, Jul. 2012. (Keyword) 国内学会
896.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 術前3D-volumetryを用いた下右肝静脈温存，右上肝静脈とドレナージ領域切除を含む合理的拡大肝前区域切除術, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
897.	Yusuke Arakawa, Mitsuo Shimada, 山田眞一郎, 淺野間理仁, 齋藤裕, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 非癌部肝組織における小胞体ストレスマーカー発現, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
898.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 齋藤裕, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 初回肝細胞癌切除後の肝移植適応を考慮した再発予測におけるUp-to-seven基準の検討, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
899.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 鏡視下肝切除定型化と肝細胞癌における短期・長期成績―基本手技とアドバンス手技―, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
900.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 山田眞一郎, 淺野間理仁, 齋藤裕, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto and Yuji Morine : 門脈灌流領域と肝静脈ドレナージ領域の詳細な解析に基づく系統的切除の妥当性, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
901.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕 and 山田眞一郎 : 症例, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
902.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 淺野間理仁 : 進行肝細胞癌に対するSorafenibの使用経験及び著効例の検討, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
903.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 細胆管細胞癌における肝幹細胞由来原発性肝腫瘍の特徴発現とその予後, 第48回日本肝癌研究会, Jul. 2012. (Keyword) 国内学会
904.	吉川雅登, Mitsuo Shimada and Yuji Morine : 右側肝円索を伴う肝門部胆管癌の切除経験, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
905.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Hiroki Mori : 肝胆膵外科領域におけるNCD登録システムの確立と術後合併症リスク評価への応用の試み, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
906.	Hiroki Mori, Hiroki Ishibashi, Toru Utsunomiya, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, 淺野間理仁, Hidenori Miyake and Mitsuo Shimada : 膵・胆管合流異常症の胆道上皮における遺伝子異常からみた治療方針, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
907.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 杉本光司 and Hidenori Miyake : 肝臓外科における菌チン蒿湯の有用性, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
908.	Yusuke Arakawa, Mitsuo Shimada, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 非癌部肝組織における小胞体ストレスマーカーの肝癌再発への関与, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
909.	淺野間理仁, Hidenori Miyake, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori and 杉本光司 : 80歳以上超高齢者における肝胆膵手術の是非, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
910.	齋藤裕, Mitsuo Shimada, 淺野間理仁, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto and Hidenori Miyake : 肝硬変における脾摘の効果と脾臓の役割, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
911.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司 and Hidenori Miyake : 術式定型化による適応拡大と原発性肝癌の治療成績 ∼短期・長期予後からみた鏡視下手術の妥当性∼, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
912.	Toru Utsunomiya, Mitsuo Shimada, 淺野間理仁, 山田眞一郎, 齋藤裕, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Mami Kanamoto : EOB-MRIによる術前シミュレーションとICG蛍光法による術中ナビゲーション∼肝切除の安全性と根治性の向上∼, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
913.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕 and 山田眞一郎 : 上右肝静脈とそのドレナージ領域合併切除を伴う鬱血領域を加味した系統的前区域切除術, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
914.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎 and Hidenori Miyake : 肝内胆管癌の長期生存獲得の条件とGFP補助療法の有用性, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
915.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎 and 淺野間理仁 : Jagged発現とIndolamine2,3-deoxygenase陽性細胞により誘導される調節性T細胞のIPMN悪性度反映に関する検討, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
916.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 佐々木一, 青沼広光 and 川島昭浩 : 高機能流動食による肝切除周術期管理―基礎的検討からRCTによる有効性評価―, 第67回日本消化器外科学会総会, Jul. 2012. (Keyword) 国内学会
917.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi and 山田眞一郎 : 分子標的薬Bevacizumabは小胞体ストレス応答を介し肝切除後の肝機能障害を改善する, 第21回日本癌病態治療研究会, Jul. 2012. (Keyword) 国内学会
918.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Tomohiko Miyatani, 杉本光司, Shuichi Iwahashi and Hidenori Miyake : ABO不適合肝移植での抗免疫療法の工夫―特に低用量ペグリバHCV療法の有用性について―, Jun. 2012. (Keyword) 国内学会
919.	吉川雅登, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁 and 山田眞一郎 : 大腸癌肝転移におけるSDF-1/CXCR4 axisの影響に関する研究, 第97回日本消化器病学会四国支部例会, Jun. 2012. (Keyword) 国内学会
920.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 淺野間理仁, 石川大地 and Hidenori Miyake : 膵・胆管合流異常症における胆道癌発癌機構の解明, 第97回日本消化器病学会四国支部例会, Jun. 2012. (Keyword) 国内学会
921.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Tomohiko Miyatani, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 大腸癌肝転移に関する諸問題と新たな治療戦略, 第37回日本外科系連合学会学術集会, Jun. 2012.
922.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎, 淺野間理仁, Horohiko Sato and Hidenori Miyake : 安全確実な肝葉切除術―出血量軽減のための工夫―, 第37回日本外科系連合学会学術集会, Jun. 2012.
923.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 齋藤裕 and 淺野間理仁 : 進行肝癌術後の肺・肺門リンパ節転移に対してソラフェニブが著効したが，肝内再発を来し肝切除を行った症例, 第6回日本肝がん分子標的治療研究会, Jun. 2012.
924.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 進行肝癌に対する集学的治療∼ソラフェニブ・IFP療法の比較∼, 第6回日本肝がん分子標的治療研究会, Jun. 2012.
925.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Hiroki Mori, Shuichi Iwahashi, 齋藤裕 and 淺野間理仁 : ヒト脂肪由来幹細胞はVEGFシグナルとは異なる経路で肝細胞傷害を軽減する, 第30回日本肝移植研究会, Jun. 2012.
926.	Shuichi Iwahashi, Mitsuo Shimada, Toru Utsunomiya, 淺野間理仁, 山田眞一郎, 齋藤裕, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine and エンヘボルトチンボルト : 高齢者ドナー肝に関する基礎的検討:肝再生及び肝障害に関して, 第30回日本肝移植研究会, Jun. 2012.
927.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Tomohiko Miyatani, Shuichi Iwahashi and Hidenori Miyake : C型肝硬変に対する肝移植後の抗ウイルス療法の工夫特に血液型不適合移植後の低用量ペグリバ療法の有用性について, 第30回日本肝移植研究会, Jun. 2012.
928.	Yusuke Arakawa, Mitsuo Shimada, Satoru Imura, Shuichi Iwahashi, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 肝細胞癌切除後の肝移植適応を考慮した再発予測におけるUp-to-seven基準の妥当性の検討, 第30回日本肝移植研究会, Jun. 2012.
929.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, 齋藤裕 and 淺野間理仁 : 大腸癌肝転移におけるSDF-1/CXCR4 axisの影響に関する検討, 第48回日本肝臓学会総会, Jun. 2012.
930.	Yusuke Arakawa, Mitsuo Shimada, Satoru Imura, 山田眞一郎, 淺野間理仁, 齋藤裕, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 非癌部肝組織におけるSTMN1・miR-223発現の肝癌多中心性再発への関与, 第48回日本肝臓学会総会, Jun. 2012.
931.	Toru Utsunomiya, Tetsuya Ikemoto, Jun Hanaoka, Mitsuo Shimada, Satoru Imura, Yuji Morine, 齋藤裕, 淺野間理仁 and 山田眞一郎 : 肝発癌分子機構におけるがん幹細胞関連DNA・miRNA発現の関与, 第48回日本肝臓学会総会, Jun. 2012.
932.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 肝内胆管癌における癌幹細胞の意義と治療抵抗性克服の可能性, 第48回日本肝臓学会総会, Jun. 2012.
933.	Yuji Morine, Mitsuo Shimada and Tetsuya Ikemoto : 癌幹細胞のepigenetic修飾と癌根治療法への可能性., 第97回日本消化器病学会総会, May 2012.
934.	矢田圭吾, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and 石川大地 : ドナー特異的抗HLA抗体陽性のレシピエントに対して生体肝移植を施行した1症例, 第14回四国肝不全研究会, May 2012.
935.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 杉本光司, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 下右肝静脈温存，上右肝静脈とそのドレナージ領域を含む合理的拡大肝S8切除術の1例, 第24回日本肝胆膵外科学会・学術集会, May 2012.
936.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 尾側膵切除における膵断端処理の工夫と膵液瘻低減に関する検討, 第24回日本肝胆膵外科学会・学術集会, May 2012.
937.	Toru Utsunomiya, Mitsuo Shimada, 齋藤裕, 山田眞一郎, 淺野間理仁, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 門脈灌流領域および肝静脈ドレナージ領域の詳細な解析に基づく合理的な拡大肝前区域切除術, 第24回日本肝胆膵外科学会・学術集会, May 2012.
938.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, 淺野間理仁 and Hidenori Miyake : 胆嚢癌に対する腹腔鏡補助下肝S4a+S5切除術の有用性についての検討, 第24回日本肝胆膵外科学会・学術集会, May 2012.
939.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕 and 山田眞一郎 : 異時性三重複胆道癌に対する外科治療, 第24回日本肝胆膵外科学会・学術集会, May 2012.
940.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 分枝型IPMNの手術適応``分子生物学的指標による評価'', 第24回日本肝胆膵外科学会・学術集会, May 2012.
941.	Yusuke Arakawa, Mitsuo Shimada, Satoru Imura, 山田眞一郎, 淺野間理仁, 齋藤裕, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 転移性肝癌と鑑別困難であった限局性類洞拡張障害の一例, 第24回日本肝胆膵外科学会・学術集会, May 2012.
942.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : EOB-MRIによるOne stop shopping肝予備能検査, 第24回日本肝胆膵外科学会・学術集会, May 2012. (Keyword) 国内学会
943.	チンボルトエンヘボルト, Mitsuo Shimada, Toru Utsunomiya, 山田眞一郎, 齋藤裕, 淺野間理仁, 杉本光司, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝切除前3Dシミュレーション画像による肝動脈，門脈，胆管の同時評価, 第66回手術手技研究会, May 2012. (Keyword) 国内学会
944.	Yusuke Arakawa, Mitsuo Shimada, Satoru Imura, 山田眞一郎, 淺野間理仁, 齋藤裕, Jun Hanaoka, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Toru Utsunomiya : 下右肝静脈温存，上右肝静脈とドレナージ領域を含む合理的拡大肝S8切除術, 第66回手術手技研究会, May 2012. (Keyword) 国内学会
945.	矢田圭吾, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, 山田眞一郎, 淺野間理仁 and 石川大地 : ドナー特異的抗HLA抗体陽性のレシピエントに対して生体肝移植術を施行した1症例, 第14回四国肝不全研究会, May 2012. (Keyword) 国内学会
946.	松本規子, Yusuke Arakawa, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎, 浅野間理仁, Hidenori Miyake and Mitsuo Shimada : ラット大量肝切除における脾臓内遺伝子発現の変化(第二報)Ingenuity Pathway Analysisを用いた検討, 第112回日本外科学会学術集会, Apr. 2012.
947.	Takuya Tokunaga, Mitsuo Shimada, Hiroki Mori, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, 淺野間理仁, 山田眞一郎 and Hidenori Miyake : Bevacizumab(Bev)が小胞体ストレス応答を介して肝切除後肝機能障害を改善する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
948.	小笠原卓, 齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 淺野間理仁, 山田眞一郎, 杉本光司, Mami Kanamoto, Jun Hanaoka, Yusuke Arakawa, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : ヒト脂肪由来幹細胞はVEGFシグナルとは異なる経路で肝細胞傷害を軽減する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
949.	西正暁, Mitsuo Shimada, Hiroki Mori, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, 山田眞一郎, 淺野間理仁, Hidenori Miyake, Eiji Takeda, Hisami Okumura, 佐々木一, 青沼広光 and 川島昭浩 : 肝切除周術期の生体侵襲に対するMEIN(R)投与の有用性の検討―基礎的実験と臨床的評価―, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
950.	篠原永光, 山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, 齋藤裕 and 淺野間理仁 : 大腸癌肝転移におけるSDF-1/CXCR4 axisの影響に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012.
951.	金村普史, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕 and 山田眞一郎 : 肝転移を有する十二指腸乳頭部癌の外科的切除を中心とした集学的治療, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
952.	Hidenori Miyake, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 幹細胞マーカーに着目した細胆管癌の悪性度に関する検討―肝内胆管癌との比較より―, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
953.	石川大地, 山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 淺野間理仁 and Hidenori Miyake : 肝硬変症例に対する脾摘後の肝再生に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
954.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto and 齋藤裕 : 脂肪由来幹細胞の傷害膵島保護作用に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012.
955.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 淺野間理仁, 山田眞一郎, 杉本光司, Mami Kanamoto, Jun Hanaoka, Yusuke Arakawa, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : ヒト脂肪由来幹細胞の傷害肝へのhoming効果に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
956.	Shuichi Iwahashi, 杉本光司, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎, 淺野間理仁, Hidenori Miyake and Mitsuo Shimada : バルプロ酸は膵癌細胞株においてインターフェロンレセプター発現を高め,抗腫瘍効果を増強する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
957.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, Chie Takasu, 山田眞一郎 and 淺野間理仁 : 膵・胆管合流異常症の胆道上皮は発癌ポテンシャルを有する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
958.	Yusuke Arakawa, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, 杉本光司, 齋藤裕, 淺野間理仁, 山田眞一郎, Hidenori Miyake and Mitsuo Shimada : Small-for-size graftにおける脾摘術は肝内のEGR1およびHO-1関連のpathwayを制御する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
959.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕, 山田眞一郎 and 淺野間理仁 : ドレナージ領域切除を含む合理的拡大肝前区域切除術, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
960.	吉川雅登, 齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 淺野間理仁, 山田眞一郎, 杉本光司, Mami Kanamoto, Jun Hanaoka, Yusuke Arakawa, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 右肝切除後の尾状葉再生に関する研究―尾状葉付き拡大左葉グラフトとの比較―, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
961.	川下陽一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 淺野間理仁 and 山田眞一郎 : より正確な系統的切除のための3D-volumetryを用いた右肝静脈周囲の門脈灌流領域に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
962.	淺野間理仁, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, 杉本光司, 齋藤裕 and 山田眞一郎 : 脾臓中マクロファージによるTGF-β発現が肝硬変に関与する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
963.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 淺野間理仁 : 紫苓湯(TJ-114)のislet xenotransolantationにおける異種移植免疫応答の減弱効果に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
964.	杉本光司, 松本慎一, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎, 淺野間理仁, Hidenori Miyake and Mitsuo Shimada : ドナー特異的輸血とHistone deacetylase阻害剤の併用は膵島移植において免疫寛容を誘導する, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
965.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎 and 淺野間理仁 : ヒト脂肪由来幹細胞を用いた傷害臓器修復に関する研究, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
966.	開野友佳理, Mitsuo Shimada, Yuji Morine, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 予後不良因子を有する進行胆道癌切除例に対するGFP補助療法の有用性, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
967.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, 杉本光司, Shuichi Iwahashi, 齋藤裕, 淺野間理仁, 山田眞一郎 and Hidenori Miyake : 過小グラフトの病態における熱ショック蛋白(HSP)低下とその対策, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
968.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : ヒストンアセチル化制御による癌幹細胞を標的とした治療抵抗性克服の可能性, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
969.	Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, 山田眞一郎, 淺野間理仁 and Hidenori Miyake : 肝発癌母地に着目した肝細胞癌の治療戦略―多中心性再発リスクに基づく治療法選択の可能性―, 第112回日本外科学会定期学術集会, Apr. 2012. (Keyword) 国内学会
970.	Yuji Morine, Shuichi Iwahashi and Mitsuo Shimada : 高齢者消化器疾患の現状と対策:肝胆膵, 第99回日本消化器病学会総会, Mar. 2012.
971.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, 齋藤裕 and 浅野間理仁 : 脂肪由来幹細胞(ADSC)の傷害膵島保護作用に関する研究., 第39回日本膵・膵島移植研究会, Mar. 2012.
972.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎 and 浅野間理仁 : TJ-114のporcine islet xenotransplantationにおける異種移植免疫応答の減弱効果に関する研究., 第39回日本膵・膵島移植研究会, Mar. 2012.
973.	Tomohiko Miyatani, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 浅野間理仁 and 山田眞一郎 : 大腸癌肝転移に対する治療戦略—Conversionと化療の肝障害軽減を目指してー., 第45回制癌剤適応研究会, Mar. 2012.
974.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 杉本光司, Mami Kanamoto, Jun Hanaoka, Yusuke Arakawa, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Hidenori Miyake : ヒト脂肪由来幹細胞はVEGFシグナルとは異なる経路で肝細胞傷害を軽減する., 第18回外科侵襲とサイトカイン研究会, Dec. 2011.
975.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 進行肝癌術後の補助療法としてのIFP療法の有用性とソラフェニブの適応提案., 第39回日本肝臓学会西部会, Dec. 2011.
976.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 胆嚢摘出術における2mm細径鉗子を用いたreduced port surgery., 第24回日本内視鏡外科学会総会, Dec. 2011.
977.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕 and Hidenori Miyake : 腹腔鏡下肝切除における術式定型化は可能である., 第24回日本内視鏡外科学会総会, Dec. 2011.
978.	Toru Utsunomiya, Mitsuo Shimada, 山田眞一郎, 浅野間理仁, 齋藤裕, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 消化器外科領域における単孔式腹腔鏡手術の功罪., 第24回日本内視鏡外科学会総会, Dec. 2011.
979.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Tetsuya Ikemoto, 山田眞一郎, 浅野間理仁, 杉本光司, Jun Hanaoka, Hiroki Mori, Yuji Morine and Satoru Imura : ヒト脂肪由来幹細胞の傷害肝へのhoming効果に関する研究., 第96回日本消化器病学会四国支部例会/第107回日本消化器内視鏡学会四国地方会, Nov. 2011.
980.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 浅野間理仁 : IPMNおよび早期膵癌における末梢血中Foxp3測定の意義., 第22回日本消化器癌発生学会総会, Nov. 2011.
981.	Toru Utsunomiya, Mitsuo Shimada, Tetsuya Ikemoto, Satoru Imura, 山田眞一郎, 浅野間理仁, 齋藤裕, Hiroki Mori, Jun Hanaoka, Yuji Morine and Mami Kanamoto : 非癌部肝組織におけるmiRNA発現プロファイルに基づく肝発癌リスク予測の試み., 第22回日本消化器癌発生学会総会, Nov. 2011.
982.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Hiroki Mori, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎, Hiroki Ishibashi and 浅野間理仁 : 膵・胆管合流異常における胆道上皮の分子生物学的検討—胆道上皮は発癌ポテンシャルを有するー., 第22回日本消化器癌発生学会総会, Nov. 2011.
983.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 術前3Dシミュレーションが可能にした右肝静脈合併切除とドレナージ領域を含む拡大肝前区域切除術 (第20回日本コンピュータ外科学会), Journal of Japan Society of Computer Aided Surgery, Vol.13, No.3, 352-353, Nov. 2011.
984.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 淺野間理仁, 山田眞一郎 and Hidenori Miyake : 癌取扱い規約のあり方 UICCとの歩み寄りは必要か? 肝癌切除例からみた癌取り扱い規約の問題点 UICCとの比較から見えたもの, Journal of Japan Surgical Association, Vol.72, 330, Nov. 2011. (Keyword) 肝細胞癌(診断); 腫瘍進行度; 保健医療水準保証 / TNM分類; *癌取扱い規約 / ヒト
985.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : 経験から学ぶ内視鏡下手術のトラブルシューティング(肝臓・胆道・膵臓) 腹腔鏡下肝切除術の短期治療成績の評価術中合併症対策を含めて, Journal of Japan Surgical Association, Vol.72, 343, Nov. 2011. (Keyword) 肝細胞癌(外科的療法); 肝切除(有害作用); 術中合併症; *腹腔鏡法(有害作用); 治療成績 / ヒト
986.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 分枝型IPMNの治療方針手術適応，縮小手術の是非 IPMNにおける末梢血中Treg比率と局所IDO陽性細胞発現の関連性の検討, Journal of Japan Surgical Association, Vol.72, 360, Nov. 2011. (Keyword) 膵臓腫瘍(病理学); 免疫組織化学; 調節T細胞; Indoleamine 2,3-Dioxygenase / 膵管内乳頭腫瘍(病理学) / ヒト
987.	Toru Utsunomiya, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 齋藤裕, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 大腸癌肝転移における新たな治療戦略切除不能大腸癌肝転移に対する肝切除へのconversionを目指した治療戦略, Journal of Japan Surgical Association, Vol.72, 372, Nov. 2011. (Keyword) Fluorouracil(治療的利用); Leucovorin(治療的利用); 肝切除; 肝臓腫瘍(転移性,薬物療法,外科的療法); 腫瘍多剤併用療法; 大腸腫瘍; ネオアジュバント療法; Irinotecan(治療的利用); Bevacizumab(治療的利用) / IFL Protocol / ヒト
988.	Yuji Morine, Mitsuo Shimada, Hiroki Mori, 高松英夫 and 嶋田紘 : 膵胆管合流異常症における手術適応および術式の再検討膵・胆管合流異常の臨床的特徴と術式選択の現状日本膵・胆管合流異常研究会報告, Journal of Japan Surgical Association, Vol.72, 376, Nov. 2011. (Keyword) *膵胆管合流異常(外科的療法) / ヒト
989.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, 齋藤裕 and 山田眞一郎 : 肝胆膵腫瘍病変における内視鏡下手術の適応拡大腹腔鏡下肝切除の定型化と肝内胆管癌への適応拡大, Journal of Japan Surgical Association, Vol.72, 420, Nov. 2011. (Keyword) 肝切除; 肝内胆管(外科的療法); 胆管癌(外科的療法); 胆管腫瘍(外科的療法); 腹腔鏡法 / ヒト
990.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 安全確実なエネルギーデバイスを駆使した無結紮肝葉切除術, Journal of Japan Surgical Association, Vol.72, 434, Nov. 2011. (Keyword) 肝切除; 外科用機器; 電気凝固 / ヒト
991.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, 荒川悠祐, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 膵頭十二指腸切除におけるVessel Sealing Systemによる安全・迅速な膵神経叢郭清, Journal of Japan Surgical Association, Vol.72, 488, Nov. 2011. (Keyword) 腫瘍侵入性; 膵頭十二指腸切除; 膵管癌(外科的療法) / ヒト
992.	Satoru Imura, Mitsuo Shimada, 山田眞一郎, 淺野間理仁, 齋藤裕, Jun Hanaoka, Mami Kanamoto, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 高度肉眼的門脈侵襲陽性の進行肝癌に対する治療戦略, Journal of Japan Surgical Association, Vol.72, 510, Nov. 2011. (Keyword) 肝細胞癌(実験的); 門脈; *流血中腫瘍細胞 / マウス; 動物
993.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 肝葉切除における中肝静脈右側切除領域に関するピットフォール, Journal of Japan Surgical Association, Vol.72, 511, Nov. 2011. (Keyword) 肝静脈(外科的療法); *肝切除 / ヒト
994.	Hiroki Mori, Mitsuo Shimada, Yuji Morine, Horohiko Sato, Hiroki Ishibashi and Toru Utsunomiya : 膵胆管合流異常症の胆道上皮の分子生物学的検討胆道上皮は発癌ポテンシャルを有する, Journal of Japan Surgical Association, Vol.72, 623, Nov. 2011. (Keyword) Histone Deacetylases; 上皮(病理学); 胆道(病理学); 腫瘍過程; *膵胆管合流異常(病理学) / ヒト
995.	江藤祥平, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 右肋骨弓下に挿入する細径鉗子はSILS胆摘導入を容易にする, Journal of Japan Surgical Association, Vol.72, 625, Nov. 2011. (Keyword) 鉗子; 肋骨; *腹腔鏡下胆嚢摘出術 / トロカール / ヒト
996.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 山田眞一郎 and 浅野間理仁 : 肝右葉切除術後の残肝再生率の検討尾状葉・外側区域・内側区域の再生率の比較, Journal of Japan Surgical Association, Vol.72, 817, Nov. 2011. (Keyword) 肝再生; 肝細胞癌(外科的療法); 肝切除; 肝臓腫瘍(外科的療法,転移性) / 尾状葉 / ヒト
997.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕 and 浅野間理仁 : 脾摘後の肝再生に関する検討, Journal of Japan Surgical Association, Vol.72, 849, Nov. 2011. (Keyword) 肝硬変(外科的療法); 肝再生; *脾臓摘出術 / ヒト
998.	山田眞一郎, 浅野間理仁, 齋藤裕, 杉本光司, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Mitsuo Shimada : 胆嚢癌に対する腹腔鏡補助下肝S4a+S5切除術., 第5回肝臓内視鏡外科研究会, Nov. 2011.
999.	Satoru Imura, 山田眞一郎, 浅野間理仁, 齋藤裕, 杉本光司, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 原発性肝癌に対する鏡視下肝切除の短期・長期成績の検討., 第5回肝臓内視鏡外科研究会, Nov. 2011.
1000.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 浅野間理仁 and Hidenori Miyake : 高齢者に対する膵頭十二指腸切除術の妥当性に関する検討., 第49回日本癌治療学会学術集会, Oct. 2011.
1001.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 杉本光司, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 切除不能大腸癌肝転移に対する化療後肝切除のベストタイミングと肝脾腫に与える影響., 第49回日本癌治療学会学術集会, Oct. 2011.
1002.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 齋藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Yuji Morine and Satoru Imura : TJ-48，TJ-137併用がStageIVb膵癌化学療法に与える影響に関する研究., 第49回日本癌治療学会学術集会, Oct. 2011.
1003.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 非癌部肝組織における分子遺伝学的特徴と肝発癌リスクに関する検討., 第49回日本癌治療学会学術集会, Oct. 2011.
1004.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 斎藤裕, 浅野間理仁 and Hidenori Miyake : 高齢者に対する膵頭十二指腸切除術の妥当性に関する検討, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 554, Oct. 2011. (Keyword) 十二指腸腫瘍(外科的療法) / 膵管内乳頭腫瘍(外科的療法) / Homo sapiens / 膵臓腫瘍(外科的療法) / 膵頭十二指腸切除 / 胆道腫瘍(外科的療法) / 高齢者(65∼79)
1005.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 杉本光司, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 切除不能大腸癌肝転移に対する化療後肝切除のベストタイミングと肝脾腫に与える影響, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 606, Oct. 2011. (Keyword) Fluorouracil(毒性・副作用,治療的利用) / 肝脾腫大(予防,化学的誘発) / ヒト / Leucovorin(毒性・副作用,治療的利用) / 肝腫脹(予防,化学的誘発) / 肝切除 / 肝臓腫瘍(転移性,薬物療法,外科的療法) / 巨脾症(予防,化学的誘発) / 腫瘍多剤併用療法 / 大腸腫瘍 / Irinotecan(毒性・副作用,治療的利用) / Oxaliplatin(毒性・副作用,治療的利用) / Bevacizumab(治療的利用) / FOLFOXIRI Protocol(毒性・副作用)
1006.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 斉藤裕, 山田眞一郎 and 浅野間理仁 : 非癌部肝組織における分子遺伝学的特徴と肝発癌リスクに関する検討, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 612, Oct. 2011. (Keyword) 肝臓腫瘍(遺伝学) / Homo sapiens / 腫瘍過程 / 遺伝子発現プロファイリング / MicroRNAs
1007.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 胆道癌術後再発に対する肝切除導入効果の検証, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 673, Oct. 2011. (Keyword) 肝切除; 腫瘍再発; 胆道腫瘍(外科的療法,予後) / ヒト
1008.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Yusuke Arakawa, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 淺野間理仁, 山田眞一郎 and Hidenori Miyake : Aurora AおよびCD44発現からみた肝癌の臨床病理学的検討, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 686, Oct. 2011. (Keyword) 肝臓腫瘍(病理学,予後); CD44抗原; Protein-Serine-Threonine Kinases / Aurora Kinase / ヒト
1009.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 杉本光司, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 脂肪由来幹細胞はcell contactを介して肝癌細胞の増殖を増強する, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 777, Oct. 2011. (Keyword) 幹細胞; 肝臓腫瘍(実験的); 脂肪組織; 共培養技術; 細胞増殖; 腫瘍細胞系
1010.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 斎藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : 膵胆管合流異常症例における胆道癌発癌機構に関する検討, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 778, Oct. 2011. (Keyword) 胆道腫瘍(病因,病理学); 腫瘍過程; 免疫組織化学; 膵胆管合流異常(合併症,病理学) / ヒト
1011.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕 and 山田眞一郎 : 胆道癌に対し3度の根治的切除が可能であった1例, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 920, Oct. 2011. (Keyword) 肝切除; 空腸(外科的療法); 膵頭十二指腸切除; 腺癌(外科的療法); 総肝管(外科的療法); 胆道腫瘍(外科的療法) / 肝管空腸吻合術; 胆道再建術 / ヒト; 中年(45∼64); 男
1012.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Hiroki Ishibashi, Horohiko Sato, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 杉本光司, 斎藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : Bevacizumabの大量肝切除後における肝障害・肝再生改善効果の基礎研究, The Journal of Japan Society for Cancer Therapy, Vol.46, No.2, 912, Oct. 2011. (Keyword) 肝再生; 肝切除; 肝臓疾患(病因,予防,実験的); 術後合併症; Wistarラット; Bevacizumab(薬理学,治療的利用) / ラット; 動物; オス
1013.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕 and 山田眞一郎 : IPMNにおいてJagged1は調節性T細胞を介し腫瘍悪性度を増強する., JDDW(日本消化器関連学会集会) 【第53回日本消化器病学会，第82回日本消化器内視鏡学会総会，第15回日本肝臓学会大会，第9回日本消化器外科学会】, Oct. 2011.
1014.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁 and 山田眞一郎 : 後期高齢者の膵・胆道癌に対する膵頭十二指腸切除術の妥当性の検討., JDDW(日本消化器関連学会集会)【第53回日本消化器病学会，第82回日本消化器内視鏡学会総会，第15回日本肝臓学会大会，第9回日本消化器外科学会】, Oct. 2011.
1015.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 杉本光司, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 切除不能大腸癌肝転移症例に対する化療後肝切除のベストタイミングと化療の影響., JDDW(日本消化器関連学会集会)【第53回日本消化器病学会，第82回日本消化器内視鏡学会総会，第15回日本肝臓学会大会，第9回日本消化器外科学会】, Oct. 2011.
1016.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 非切除胆管癌に対する集学的治療—``Conversion''を目指してー., JDDW(日本消化器関連学会集会)【第53回日本消化器病学会，第82回日本消化器内視鏡学会総会，第15回日本肝臓学会大会，第9回日本消化器外科学会】, Oct. 2011.
1017.	Toru Utsunomiya, Mami Kanamoto, Jun Hanaoka, 山田眞一郎, 齋藤裕, 岩橋衆一, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Mitsuo Shimada, 浅野間理仁 and Hidenori Miyake : 非癌部肝組織の遺伝子発現・miRNA発現パターンに基づく肝発癌のリスクの分子診断., JDDW(日本消化器関連学会集会)【第53回日本消化器病学会，第82回日本消化器内視鏡学会総会，第15回日本肝臓学会大会，第9回日本消化器外科学会】, Oct. 2011.
1018.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 膵癌における血中調節性T細胞を指標とした早期診断の可能性と理論的根拠, JDDW(日本消化器関連学会集会) 【第53回日本消化器病学会，第82回日本消化器内視鏡学会総会，第15回日本肝臓学会大会，第9回日本消化器外科学会】, Vol.108, A907, Oct. 2011. (Keyword) 膵臓腫瘍(診断); 膵管癌(診断); 早期診断; 調節T細胞 / 膵管内乳頭腫瘍(診断) / ヒト
1019.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 斎藤裕 and Hidenori Miyake : ヒト脂肪由来幹細胞(ADRCs)の傷害膵島保護作用に関する検討, 第47回日本移植学会総会, Vol.46, 203, Oct. 2011. (Keyword) Langerhans島; 脂肪組織; 組織培養技術; *間葉系幹細胞 / ブタ; 動物
1020.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 斉藤裕 and 松本慎一 : 膵島移植におけるdonor specific transfusionとhistone deacetylase inhibitorによる免疫寛容誘導の検討, 第47回日本移植学会総会, Vol.46, 206, Oct. 2011. (Keyword) Langerhans島移植(実験的); ドナー; 免疫寛容; 輸血(実験的); Histone Deacetylase Inhibitors / *ドナー特異的輸血(実験的) / マウス; 動物
1021.	Tetsuya Ikemoto, Mitsuo Shimada, 松本慎一, 岩橋衆一, Yuji Morine, Satoru Imura, Toru Utsunomiya and Jacque Banchereau : 各臓器移植における免疫寛容 IFN inducible IDO+形質細胞様樹状細胞による免疫寛容誘導, 第47回日本移植学会総会, Vol.46, 129, Oct. 2011. (Keyword) Interferons; 樹状細胞; 免疫寛容; Indoleamine 2,3-Dioxygenase / *形質細胞様樹状細胞
1022.	杉本光司, 島田光生, 宇都宮徹, 居村暁, Yuji Morine, 池本哲也, 森大樹, 花岡潤, 金本真美, 斉藤裕 and 松本慎一 : 膵島移植におけるdonor specific transfusionとhistone deacetylase inhibitorによる免疫寛容誘導の検討, 第47回日本移植学会総会, Vol.46, 206, Oct. 2011. (Keyword) Langerhans島移植(実験的) / ドナー特異的輸血(実験的) / マウス; 動物 / ドナー / 免疫寛容 / 輸血(実験的) / Histone Deacetylase Inhibitors
1023.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 山田眞一郎, 浅野間理仁, 杉本光司, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : ヒト脂肪由来幹細胞による肝虚血再灌流障害軽減効果に関する基礎的検討, 第47回日本移植学会総会, Vol.46, 254, Oct. 2011. (Keyword) 肝臓疾患(実験的,治療); 虚血(実験的,治療); 再灌流損傷(予防); BALB Cマウス; 間葉系幹細胞移植(実験的) / ヒト; マウス; 動物
1024.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕 and 浅野間理仁 : Indoleamine 2, 3-dioxygenase (IDO) induced active regulatory Tcells play an important role in pancreatic neoplasms, Proceedings of the Japanese Cancer Association, 80, Oct. 2011.
1025.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎, 浅野間理仁, 岩橋衆一 and Hidenori Miyake : Role of CD 151 expression in gallbladde carcinoma, Proceedings of the Japanese Cancer Association, 122, Oct. 2011.
1026.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Valproic acid enhances the anti-tumor effect of pegylated interferon-alpha toward pancreatic cancer cell lines, Proceedings of the Japanese Cancer Association, 140, Oct. 2011.
1027.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 花岡潤, 杉本光司, 浅野間理仁 and 山田眞一郎 : 肝虚血再灌流傷害におけるヒト脂肪由来幹細胞ホーミング効果の機序解明 (第70回日本癌学会学術総会), Proceedings of the Japanese Cancer Association, 403-404, Oct. 2011.
1028.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕, 山田眞一郎 and 浅野間理仁 : miRNA expression profiles of non-tumor liver tissues in patients with hepatocellular carcinoma ( 70 ), Proceedings of the Japanese Cancer Association, 448, Oct. 2011.
1029.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 肝葉切除における中肝静脈右側切除領域に関する検討., 第6回肝癌治療シミュレーション研究会, Sep. 2011.
1030.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 非切除胆管癌に対する集学的治療 GFP療法から切除へ, Journal of Japan Biliary Association, Vol.25, No.3, 407, Sep. 2011. (Keyword) Cisplatin(治療的利用); Fluorouracil(治療的利用); 腫瘍多剤併用療法; 胆管癌(薬物療法,外科的療法); 胆管腫瘍(薬物療法,外科的療法); 胆道外科; 治療成績; ネオアジュバント療法; Gemcitabine(治療的利用) / *胆管切除術 / ヒト
1031.	Hiroki Mori, Mitsuo Shimada, 久山寿子, Hiroki Ishibashi, Horohiko Sato, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁 and 山田眞一郎 : ラット胆管拡張症モデルを用いた膵・胆管合流異常症に関する実験的検討, Journal of Japan Biliary Association, Vol.25, No.3, 499, Sep. 2011. (Keyword) 疾患モデル(動物); 胆道腫瘍(化学的誘発,実験的); 有機スズ化合物(毒性・副作用); Ki-67抗原; Lewラット; 膵胆管合流異常(化学的誘発,実験的); 胆道拡張症(化学的誘発,実験的) / Dibutyldichlorotin(毒性・副作用) / ラット; 動物; オス
1032.	淺野間理仁, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, 齋藤裕 and 山田眞一郎 : 門脈圧亢進症における臓器相関肝・肺・腎・脾肝硬変症の脾臓では肝・脾連関によりTGF-βが高発現する, Japanese Journal of Portal Hypertension, Vol.17, No.3, 45, Sep. 2011. (Keyword) Transforming Growth Factor Beta; 肝硬変; *脾臓(病理学,外科的療法); 脾臓摘出術; 病理解剖 / ヒト
1033.	Hiroki Mori, Mitsuo Shimada, Satoru Imura, 浅野間理仁, 山田眞一郎, 斎藤裕, 杉本光司, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 肝硬変に対する外科的治療としての脾摘術の意義, Japanese Journal of Portal Hypertension, Vol.17, No.3, 50, Sep. 2011. (Keyword) 肝硬変(合併症,外科的療法); 肝切除(実験的); 肝臓腫瘍(合併症); 脾臓摘出術; Wistarラット; マイクロアレイ解析 / ヒト; ラット; 動物; 男; 女; オス
1034.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 斎藤裕, 山田眞一郎, 浅野間理仁, Hiroki Mori and Hidenori Miyake : Major shuntの有無に着目した肝硬変に対する脾摘術の効果, Japanese Journal of Portal Hypertension, Vol.17, No.3, 121, Sep. 2011. (Keyword) 肝硬変(外科的療法); 肝循環; 脾臓摘出術 / ヒト
1035.	Yuji Morine : 膵・胆管合流異常の特徴と術式選択の現状., 第34回日本膵・胆管合流異常研究会, Sep. 2011.
1036.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 浅野間理仁 and Hiroki Ishibashi : 胆嚢摘出術を施行後，20年経過して胆管癌を発症した胆管非拡張型膵・胆管合流異常の1例, 日本膵・胆管合流異常研究会プロシーディングス, Vol.34, 46-47, Sep. 2011. (Keyword) 腫瘍マーカー; 胆管癌(X線診断,外科的療法,合併症); 胆管腫瘍(X線診断,外科的療法,合併症); 内視鏡的逆行性胆道膵管造影; X線CT; 胆嚢摘出術; 致死的転帰; 膵胆管合流異常(X線診断,外科的療法,合併症); 病理解剖 / 内視鏡的胆管ドレナージ / ヒト; 高齢者(65∼79); 男
1037.	Hiroki Mori, Mitsuo Shimada, Yuji Morine, Horohiko Sato, Hiroki Ishibashi, Toru Utsunomiya and 浅野間理仁 : 膵・胆管合流異常症の胆道上皮における分子生物学的検討, 日本膵・胆管合流異常研究会, Vol.34, 52, Sep. 2011. (Keyword) Histone Deacetylases; 遺伝子発現; 腫瘍マーカー; 上皮; 胆道; Ki-67抗原; *膵胆管合流異常(外科的療法,遺伝学) / ヒト
1038.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 膵頭十二指腸切除術におけるVessel sealing systemを用いた安全かつ迅速な膵背側離断., 第65回手術手技研究会, Sep. 2011.
1039.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka and Mami Kanamoto : 画像上極めて特異な像を示した高度脂肪化を伴うHCCの1症例., 第55回日本消化器画像診断研究会, Sep. 2011.
1040.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 杉本光司, 齋藤裕 and 山田眞一郎 : 腹腔鏡下肝切除における術式定型化とその工夫., 第86回中国四国外科学会総会/第16回中国四国内視鏡外科研究会, Sep. 2011.
1041.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎 and 浅野間理仁 : C型肝硬変に対するABO不適合肝移植後の低用量Peg-IFN/RBV療法の有用性., 第29回中国四国臨床臓器移植研究会, Aug. 2011.
1042.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 杉本光司, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : ヒト脂肪由来幹細胞による肝傷害軽減効果に関する基礎的検討., 第29回日本ヒト細胞学会学術集会, Aug. 2011.
1043.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 浅野間理仁 : 脂肪組織由来幹細胞は膵β細胞障害を軽減する., 第243回徳島医学会学術集会, Jul. 2011.
1044.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 山田眞一郎, 浅野間理仁, Hiroki Mori and Hidenori Miyake : 膵癌における調節性T細胞を指標とした早期診断の可能性と理論的根拠., 第243回徳島医学会学術集会, Jul. 2011.
1045.	Tovuu Lkhagva-Ochir, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Syuichi Iwahashi, Yu Saito, Nobuhiro Kurita and Hidenori Miyake : CD44 expression in the non-tumor tissues is correlated to the prognosis of the patients with hepatocellular carcinoma., 第47回日本肝癌研究会, Jul. 2011.
1046.	齋藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : Case report multiple cancer of liver, stomach and lung which is difficult to make differential diagnosis and to decide on courses of treatment., 第47回日本肝癌研究会, Jul. 2011.
1047.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : Clinicopathological features on long-term survival after hepatic resection for hepatocellular carcinoma., 第47回日本肝癌研究会, Jul. 2011.
1048.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : Hepatoprotective effect and reductive effect of splenomegaly by using bevacizumab in L-OHP regimen., 第47回日本肝癌研究会, Jul. 2011.
1049.	山田眞一郎, Mitsuo Shimada, 浅野間理仁, 齋藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 症例., 第47回日本肝癌研究会, Jul. 2011.
1050.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : Cholangiolocellular ccarcinoma has a feature of a progenitor cell origin., 第47回日本肝癌研究会, Jul. 2011.
1051.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, Mami Kanamoto and Hidenori Miyake : Standardization for laparoscopic hepatectomy of hepatocellular carcinoma., 第47回日本肝癌研究会, Jul. 2011.
1052.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori and Jun Hanaoka : Treatment strategy for avoiding small -for-size graft in LDLT using left lobe graft., 第47回日本肝癌研究会, Jul. 2011.
1053.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 浅野間理仁 and 山田眞一郎 : Treatment strategy by molecular and genetics approach for non-B non-C hepatocellular caracinoma., 第47回日本肝癌研究会, Jul. 2011.
1054.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 山田眞一郎, 浅野間理仁, 齋藤裕, 岩橋衆一, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto and Yuji Morine : Prediction and treatment strategy for recurrent hepatocellular carcinoma based on the profiles of both gene and miRNA expressions., 第47回日本肝癌研究会, Jul. 2011.
1055.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 浅野間理仁, 山田眞一郎, 齋藤裕, 岩橋衆一, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto and Yuji Morine : 尾状葉付き拡大左葉グラフトの術後尾状葉再生率に関する検討., 第29回日本移植研究会, Jul. 2011.
1056.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 山田眞一郎 and 浅野間理仁 : ヒト脂肪由来幹細胞による肝細胞障害軽減効果に関する基礎的検討., 第29回日本移植研究会, Jul. 2011.
1057.	Satoru Imura, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 浅野間理仁 and 山田眞一郎 : 左葉グラフトを用いた成人生体肝移植の成績∼Small-for-size graftは術後成績のリスクファクターではない∼., 第29回日本移植研究会, Jul. 2011.
1058.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, 岩橋衆一, Hiroki Mori, Mami Kanamoto and Hidenori Miyake : EOB-MRIを用いた肝切除術前検査のone stop shopping, 日本消化器外科学会総会, 207, Jul. 2011. (Keyword) 肝切除; 肝機能検査; MRI; 術前診断; Gadoxetic Acid(診断的利用) / ヒト
1059.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕 and Hidenori Miyake : 胆管非拡張型膵・胆管合流異常に対する診断と治療全国集計からみた膵・胆管合流異常の特徴と当科における症例の発癌関連遺伝子発現の評価, 日本消化器外科学会総会, 260, Jul. 2011. (Keyword) 遺伝子発現; 胆管癌(病因); 胆管腫瘍(病因); 胆嚢腫瘍(病因); 腫瘍過程; 膵胆管合流異常(合併症,遺伝学,外科的療法) / ヒト
1060.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto and Hidenori Miyake : 消化器癌に対する分子生物学の臨床応用(肝胆膵・上部消化管) 肝発癌における非癌部肝組織miRNA発現の意義, 日本消化器外科学会総会, 268, Jul. 2011. (Keyword) 肝細胞癌(遺伝学); 腫瘍過程; MicroRNAs / ヒト
1061.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto and Hidenori Miyake : 最新デバイスを駆使した無結紮肝葉切除術の定型化若手外科医の習熟のための工夫, 日本消化器外科学会総会, 441, Jul. 2011. (Keyword) *肝切除; 医学生涯教育; 外科的ステープリング / ヒト
1062.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一 and Hidenori Miyake : 高度脈管侵襲陽性肝癌術後のSystemic IFN+low-dose FPの有用性理論的根拠と臨床成績, 日本消化器外科学会総会, 442, Jul. 2011. (Keyword) Cisplatin(治療的利用); Interferons(治療的利用); Polyethylene Glycols(治療的利用); 肝細胞癌(実験的,外科的療法,薬物療法); 腫瘍多剤併用療法(実験的); 腫瘍侵入性; 流血中腫瘍細胞; アジュバント化学療法(実験的); 治療成績; Tegafur-Uracil(治療的利用) / Polyethylene Glycol-Interferons(治療的利用); *FP Protocol / マウス; 動物
1063.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka and Mami Kanamoto : 宿主免疫学反応から見たIPMNの手術適応, 日本消化器外科学会総会, 444, Jul. 2011. (Keyword) 膵臓腫瘍(外科的療法,病理学); 調節T細胞 / 膵管内乳頭腫瘍(外科的療法,病理学) / ヒト
1064.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, Mami Kanamoto and Hidenori Miyake : 腹腔鏡下肝切除術の低侵襲性の検証開腹vs.補助下vs.完全鏡視下, 日本消化器外科学会総会, 467, Jul. 2011. (Keyword) 開腹術; 肝切除; 腹腔鏡法; *最小侵襲手術 / ヒト
1065.	Toru Utsunomiya, Mitsuo Shimada, Mami Kanamoto, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 進行大腸癌肝転移例に対する治療のコンセプト肉眼的根治を目指した化療導入による肝切除へのconversion, 日本消化器外科学会総会, 504, Jul. 2011. (Keyword) 肝切除; 肝臓腫瘍(転移性,外科的療法,薬物療法); *大腸腫瘍 / ヒト
1066.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, 斎藤裕 and Hidenori Miyake : 障害肝に対する肝予備能評価アシアロシンチグラフィーとEOB-MRIの応用, 日本消化器外科学会総会, 516, Jul. 2011. (Keyword) 肝機能検査; MRI; *放射性核種イメージング; Gadoxetic Acid(診断的利用); 黄疸-閉塞性 / ヒト
1067.	石川大地, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 齋藤裕, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 初発および再発細胆管細胞癌に対して外科的切除を施行した1例., 第95回日本消化器病学会四国支部例会, Jun. 2011.
1068.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 浅野間理仁 : 脂肪由来幹細胞(ADRCs)は液性因子による障害膵島保護作用を有する., 第95回日本消化器病学会四国支部例会, Jun. 2011.
1069.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : IPMN悪性度判定においてJagged1発現は有用である., 95回日本消化器病学会四国支部例会, Jun. 2011.
1070.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 浅野間理仁 : Bevacizumabの大量肝切除後における肝障害・肝再生改善効果の基礎検討., 第95回日本消化器病学会四国支部例会, Jun. 2011.
1071.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 齋藤裕, 山田眞一郎 and 浅野間理仁 : One stop shoppingに施行可能なEOB-MRIを用いた肝切除術前検査., 第95回日本消化器病学会四国支部例会, Jun. 2011.
1072.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Hidenori Miyake : 再生医療の現状と将来展望ヒト脂肪由来幹細胞の肝再生における役割, Journal of Japanese College of Surgeons, Vol.36, No.3, 345, Jun. 2011. (Keyword) Heparin(薬理学); 肝再生; 幹細胞; 細胞生存; 脂肪組織; 共培養技術; BALB Cマウス; 肝細胞; 再生医学; *幹細胞移植(実験的) / ヒト; マウス; 動物
1073.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 肝胆膵悪性腫瘍手術における血行再建肝細胞癌に対する左葉グラフト肝移植における肝静脈再建吻合口拡大のための工夫, Journal of Japanese College of Surgeons, Vol.36, No.3, 370, Jun. 2011. (Keyword) 肝細胞癌(外科的療法); 肝静脈(外科的療法); 肝臓移植; 血管外科; *吻合術 / ヒト
1074.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 進行肝細胞癌に対するSorafenibの使用経験及び著効例の検討, Journal of Japanese College of Surgeons, Vol.36, No.3, 391, Jun. 2011. (Keyword) 肝細胞癌(薬物療法); 治療成績; Sorafenib(治療的利用,毒性・副作用) / ヒト
1075.	Satoru Imura, Mitsuo Shimada, 山田眞一郎, 淺野間理仁, 齋藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 超高齢者肝細胞癌に対する肝切除術の妥当性の検討, Journal of Japanese College of Surgeons, Vol.36, No.3, 529, Jun. 2011. (Keyword) 肝細胞癌(外科的療法,病理学,予後); 肝切除; *高齢者保健医療サービス; 治療成績 / ヒト; 高齢者(80∼); 歯学
1076.	Yuji Morine, Mitsuo Shimada, 高松英夫 and 嶋田紘 : 膵・胆管合流異常と癌発生率膵・胆管合流異常研究会全国集計から, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 129, Jun. 2011. (Keyword) *膵胆管合流異常(疫学) / ヒト
1077.	Toru Utsunomiya, Mitsuo Shimada, 斉藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 肝胆膵外科手術の安全性，根治性を高める画像解析と術前シミュレーション肝切除術前シミュレーションとしてのEOB-MRIの応用 3D-volumetryの融合による肝機能と肝容積の同時評価, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 157, Jun. 2011. (Keyword) 肝切除; 肝臓(画像診断); MRI; 術前診断; 臓器サイズ; コンピュータシミュレーション; 三次元イメージング; Gadoxetic Acid(診断的利用) / ヒト
1078.	淺野間理仁, Mitsuo Shimada, 山田眞一郎, 齋藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 転移性肝癌における手術適応とタイミング切除不能大腸癌肝転移例に対する化療後肝切除のタイミングと化療の影響, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 178, Jun. 2011. (Keyword) 肝切除; 肝臓腫瘍(転移性,外科的療法,薬物療法); *大腸腫瘍 / ヒト
1079.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 単孔式腹腔鏡下胆嚢摘出術従来法との比較(2) 細径鉗子を用いたHybrid SILSの有用性に関する検討, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 206, Jun. 2011. (Keyword) 鉗子; *腹腔鏡下胆嚢摘出術; 治療成績 / トロカール / ヒト; 男; 女
1080.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 次世代の肝胆膵外科を目指してヒト脂肪由来幹細胞による肝再生療法に関する基礎的検討, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 222, Jun. 2011. (Keyword) 肝再生; 細胞分化; 脂肪組織(移植); 肝細胞; 幹細胞移植(実験的) / ヒト; マウス; 動物
1081.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : 高度肉眼的門脈侵襲陽性の進行肝癌に対する治療戦略, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 243, Jun. 2011. (Keyword) Cisplatin(治療的利用); Interferons(治療的利用); Polyethylene Glycols(治療的利用); 肝細胞癌(実験的,薬物療法); 腫瘍多剤併用療法; 門脈; *流血中腫瘍細胞; Tegafur-Uracil(治療的利用) / Polyethylene Glycol-Interferons(治療的利用); FP Protocol / マウス; 動物
1082.	Mami Kanamoto, Mitsuo Shimada, Yuji Morine, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 胆膵領域癌における有用な術前，術後補助療法進行胆道癌に対するGFP療法の有用性, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 248, Jun. 2011. (Keyword) Cisplatin(治療的利用); 腫瘍多剤併用療法; 胆道腫瘍(薬物療法); 治療成績; Gemcitabine(治療的利用); Tegafur-Uracil(治療的利用) / *FP Protocol / ヒト
1083.	Toru Utsunomiya, Mitsuo Shimada, 斉藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 安全かつ確実な腹腔鏡下肝切除術を目指して(1) 腹腔鏡下肝切除術の短期治療成績の評価および術中合併症対策, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 256, Jun. 2011. (Keyword) 肝細胞癌(外科的療法); 肝切除(有害作用); 空気塞栓症(病因,予防); 術中合併症; 腹腔鏡法(有害作用); 失血-外科(病因,予防); 治療成績 / ヒト
1084.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 肝切除術の新たな工夫(2) 若手にも導入容易なエネルギーデバイスを駆使した無結紮肝葉切除術, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 265, Jun. 2011. (Keyword) 肝切除(有害作用); 電気凝固; 失血-外科(病因,予防); 超音波メス / ヒト
1085.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Mami Kanamoto, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : Vessel sealing systemによる神経叢郭清, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 282, Jun. 2011. (Keyword) 腫瘍侵入性; リンパ節郭清; 上腸間膜動脈; 膵管癌(外科的療法) / ヒト
1086.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : CACS(celiac axis compression syndrome)により術後管理に難渋した膵頭十二指腸切除の1例, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 344, Jun. 2011. (Keyword) 病的狭窄(合併症,外科的療法); 十二指腸疾患(合併症,外科的療法); 術後管理; 膵頭十二指腸切除 / 腹腔動脈起始部圧迫症候群(合併症) / ヒト; 男
1087.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, 岩橋衆一, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 非B非C型肝癌再発に対する分子遺伝学的治療戦略遺伝子およびmiRNA発現のハイブリッド解析から, Acta Hepatologica Japonica, Vol.52, No.Suppl.1, A62, Jun. 2011. (Keyword) 肝細胞癌(遺伝学,外科的療法); 肝切除; 腫瘍再発; 遺伝子チップ; MicroRNAs / ヒト
1088.	Toru Utsunomiya, Mitsuo Shimada, 浅野間理仁, 齋藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 切除不能大腸癌肝転移例に対する肉眼的根治を目指した外科的治療戦略, Acta Hepatologica Japonica, Vol.52, No.Suppl.1, A131, Jun. 2011. (Keyword) Fluorouracil(治療的利用); Leucovorin(治療的利用); 肝切除(実験的); 肝臓腫瘍(転移性,外科的療法,薬物療法); 腫瘍多剤併用療法; 疾患モデル(動物); 大腸腫瘍; Irinotecan(治療的利用); Oxaliplatin(治療的利用); Bevacizumab(治療的利用) / IFL Protocol; FOLFOX Protocol / ラット; 動物
1089.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 岩橋衆一, 斎藤裕, Mami Kanamoto and Hidenori Miyake : EOB-MRIは肝切除術前検査をone stop shoppingに施行可能である, Acta Hepatologica Japonica, Vol.52, No.Suppl.1, A441, Jun. 2011. (Keyword) 肝細胞癌(画像診断,外科的療法); 肝切除; MRI; 術前診断; Gadoxetic Acid(診断的利用) / ヒト
1090.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 岩橋衆一, 齋藤裕, Mami Kanamoto and Hidenori Miyake : EOB‐MRIは肝切除術前検査をone stop shoppingに施行可能である, 第47回日本肝臓学会総会, Jun. 2011.
1091.	Toru Utsunomiya, Mitsuo Shimada, 浅野間理仁, 齋藤裕, 岩橋衆一, Mami Kanamoto, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Hidenori Miyake : 切除不能大腸癌肝転移例に対する肉眼的根治を目指した外科的治療戦略, 第47回日本肝臓学会総会, Jun. 2011.
1092.	久山寿子, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroo Takehara and Akira Nii : 膵・胆管合流異常症に関する実験的検討:ラット胆管拡張モデル., 第111回日本外科学会定期学術集会, May 2011.
1093.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁, Hidenori Miyake and Yoshimi Bando : SY-2-6 IPMNにおけるJagged1発現の意義に関する研究 : 調節性T細胞上昇の機序解明の観点から(SY-2 シンポジウム(2)IPMNをめぐる諸問題-診断から治療まで-,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 231, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573387451828484736 (CiNii: 1573387451828484736)
1094.	Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Hidenori Miyake : 切除不能大腸癌肝転移に対する治癒を目指した治療戦略と肝臓外科医の役割(PD3 パネルディスカッション(3)大腸癌肝転移に対する肝切除と非外科的治療の役割分担,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 267, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570291227084133248 (CiNii: 1570291227084133248)
1095.	Yuji Morine, Mitsuo Shimada, 高松英夫 and Seiki Tashiro : PD-8-1 全国集計からみた非拡張型膵・胆管合流異常の特徴と胆道癌発生頻度(PD8 パネルディスカッション(8)胆道拡張のない膵・胆管合流異常症,膵管形成異常症の治療:成人領域と小児領域,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 277, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571135652014252288 (CiNii: 1571135652014252288)
1096.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 浅野間理人 : 脂肪由来幹細胞(ADRCs)の傷害膵島保護作用に関する検討(SF-011 サージカルフォーラム(11)膵臓:基礎-4,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 349, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570009752108919680 (CiNii: 1570009752108919680)
1097.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 山田眞一郎 and Hidenori Miyake : 胆管癌細胞においてHDAC阻害剤はGemcitabineの抗腫瘍効果を増強する : Ingenuity Pathways AnalysisによるGene networkに着目して(SF-014 サージカルフォーラム(14)胆管:基礎,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 352, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571417126992470656 (CiNii: 1571417126992470656)
1098.	Hidenori Miyake, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 胆嚢癌におけるCD151発現の意義(SF-014 サージカルフォーラム(14)胆管:基礎,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 353, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570572702062358016 (CiNii: 1570572702062358016)
1099.	篠原永光, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 川下陽一郎, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : 大量肝切除前後での脾臓の役割に関する研究(第2報) : Ingenuity Pathway Analysisによる系統的解析(SF-021 サージカルフォーラム(21)門脈,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 361, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571980076945895040 (CiNii: 1571980076945895040)
1100.	Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 遺伝子とmiRNA発現のハイブリッド解析による非B非C肝癌再発に対する分子遺伝学的治療戦略(SF-059 サージカルフォーラム(59)肝臓:基礎-2,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 409, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570572702061427456 (CiNii: 1570572702061427456)
1101.	鷹村和人, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 3D volumetryとICGR15を用いた肝切除限界量の検討(サージカルフォーラム(96)肝臓:診断-1,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 456, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573950401782239104 (CiNii: 1573950401782239104)
1102.	四方祐子, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎 and Hidenori Miyake : 抗EGFR抗体は大量肝切除後の肝傷害,肝再生に影響を及ぼすか?(サージカルフォーラム(98)肝臓:基礎-4,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 458, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573668926805539328 (CiNii: 1573668926805539328)
1103.	徳永卓哉, Mitsuo Shimada, 齋藤裕, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 脂肪由来幹細胞は肝細胞傷害を軽減する(サージカルフォーラム(99)肝臓:基礎-5,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 459, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570854177038413312 (CiNii: 1570854177038413312)
1104.	黒田武志, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎 and Hidenori Miyake : 脂肪由来幹細胞はcell contactを介して肝癌細胞の増殖を増強する(サージカルフォーラム(99)肝臓:基礎-5,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 459, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573387451828820608 (CiNii: 1573387451828820608)
1105.	寺澤敏秀, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎 and Hidenori Miyake : 細胆管細胞癌は肝幹細胞由来の原発性肝腫瘍の特徴を有する : 幹細胞マーカーの発現パターンに着目して(サージカルフォーラム(100)肝臓:基礎-6,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 460, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573950401782233984 (CiNii: 1573950401782233984)
1106.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : ヒストンアセチル化に基づく消化器癌幹細胞制御の可能性(サージカルフォーラム(100)肝臓:基礎-6,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 461, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573950401782228352 (CiNii: 1573950401782228352)
1107.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : EOB-MRIと3D-volumetryの融合により肝機能と肝容積の同時評価が可能である(PS-022 ポスターセッション(22)肝臓:診断-1,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 544, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571698601967593216 (CiNii: 1571698601967593216)
1108.	小笠原卓, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : ソラフェニブは肝切除後の肝障害や肝再生に影響を及ぼすか?(PS-025 ポスターセッション(25)肝臓:集学的治療-2,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 549, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573668926804558848 (CiNii: 1573668926804558848)
1109.	淺野間理仁, Mitsuo Shimada, Hiroki Mori, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 肝硬変症の脾臓におけるTGF-β発現の意義(PS-067 ポスターセッション(67)脾臓-1,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 620, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571417126992920704 (CiNii: 1571417126992920704)
1110.	松本規子, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 黄疸肝における遺伝子発現の変化(第2報) : Ingenuity Pathways Analysisによる遺伝子ネットワーク解析(PS-102 ポスターセッション(102)肝臓:基礎-3,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 681, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570572702061026816 (CiNii: 1570572702061026816)
1111.	Mami Kanamoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : Bevacizumab投与は大量肝切除後の肝障害・肝再生を改善する(PS-102 ポスターセッション(102)肝臓:基礎-3,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 682, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571980076944575744 (CiNii: 1571980076944575744)
1112.	西正暁, Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and Hidenori Miyake : 非癌部肝組織におけるmiRNA発現の多中心性肝発癌への関与 : miRNAマイクロアレイを用いた網羅的解析(PS-130 ポスターセッション(130)肝臓:基礎-5,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 730, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573668926804984320 (CiNii: 1573668926804984320)
1113.	開野友佳理, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 高圧酸素療法(HBO)の肝preconditioning効果(Microarray) : Ingenuity Pathways Analysisによる系統的解析(PS-130 ポスターセッション(130)肝臓:基礎-5,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 730, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572543026898127360 (CiNii: 1572543026898127360)
1114.	金村普史, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 胆嚢摘出術における細径鉗子を用いたHybrid SILSの有用性(PS-135 ポスターセッション(135)胆管:良性-2,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 738, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572543026898121600 (CiNii: 1572543026898121600)
1115.	川下陽一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and Hidenori Miyake : 胆嚢癌におけるSki発現の意義(PS-140 ポスターセッション(140)胆管:悪性-5,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 748, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573668926804992768 (CiNii: 1573668926804992768)
1116.	杉本光司, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto and 松本慎一 : TJ-48が1型糖尿病マウス(NOD mouse)糖尿発症に及ぼす影響に関する研究(PS-142 ポスターセッション(142)膵臓:移植,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 752, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570854177039097856 (CiNii: 1570854177039097856)
1117.	Yusuke Arakawa, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 川下陽一郎, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : PS-204-5 最新デバイスを駆使し定型化した肝葉切除術 : 若手外科医の習熟のための工夫(PS-204 ポスターセッション(204)肝臓:手術-7,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 860, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573387451829191936 (CiNii: 1573387451829191936)
1118.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 川下陽一郎, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : 術後肝不全を回避するための黄疸肝に対する3つの工夫(PS-206 ポスターセッション(206)肝臓:周術期管理-1,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 862, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570572702062078848 (CiNii: 1570572702062078848)
1119.	Akira Nii, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁, Hidenori Miyake, Eiji Takeda, Hisami Okumura, 佐々木一, 青沼広光 and 川島昭浩 : 肝切除周術期MEINR投与の有用性についての検討 : 基礎的実験とRCT(PS-206 ポスターセッション(206)肝臓:周術期管理-1,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 863, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573668926805901568 (CiNii: 1573668926805901568)
1120.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : PS-207-6 Catechinは大量肝切除後の肝傷害を軽減し肝再生を促進する(PS-207 ポスターセッション(207)肝臓:周術期管理-2,第111回日本外科学会定期学術集会), Journal of Japan Surgical Society, Vol.112, No.1, 865, May 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571980076945628032 (CiNii: 1571980076945628032)
1121.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁, 山田眞一郎, Nobuhiro Kurita, Hidenori Miyake and Hiroshi Shibata : 非代償性肝硬変に対する外科的治療としての脾摘術の意義., 第97回日本消化器病学会総会, May 2011.
1122.	Yuji Morine, Mitsuo Shimada and Tetsuya Ikemoto : 癌幹細胞のepigenetic修飾と癌根治療法への可能性, 第97回日本消化器病学会総会, May 2011.
1123.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 浅野間理仁 and Hidenori Miyake : ABO不適合肝移植により救命した急性肝不全症例の1例., 第13回四国肝不全研究会, Apr. 2011.
1124.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Kouzou Yoshikawa, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : 腸管ストレスに対する大建中湯(DKT)の可能性-バクテリアルトランスローケーションからマイクロビオーム, 第47回日本腹部救急医学会総会, Mar. 2011.
1125.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 斎藤裕, 山田眞一郎 and 浅野間理仁 : ヒストン脱アセチル化酵素阻害剤による胆管癌細胞株に対する化学療法増強効果の検討, 第44回制癌剤適応研究会, Mar. 2011.
1126.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : Bevacizumab 投与の大量肝切除後における肝障害・肝再生改善効果, 第44回制癌剤適応研究会, Mar. 2011.
1127.	Yuji Morine, Mitsuo Shimada and Tetsuya Ikemoto : 癌幹細胞のepigenetic修飾と癌根治療法への可能性, 第97回日本消化器病学会総会, Mar. 2011.
1128.	浅野間理仁, Mitsuo Shimada, Hiroki Mori, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 肝硬変の脾臓におけるTGF-β発現の意義, 第242回徳島医学会学術集会, Feb. 2011.
1129.	Satoru Imura, Mitsuo Shimada, 山田眞一郎, 浅野間理仁, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 高度肉眼的門脈侵襲陽性の進行肝癌に対する治療戦略—理論的根拠と臨床成績—., 第242回徳島医学会学術集会, Feb. 2011.
1130.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 金本真美, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 薬剤性肝炎，汎発性腹膜炎，肺アスペルギルス症による肺出血，創傷治癒遷延など様々な合併症を来したHCCの1例, 第19回徳島外科術後管理研究会, Feb. 2011.
1131.	斎藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, 川下陽一郎, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 進行肝細胞癌に対するソラフェニブの成績, 第3回日本肝がん分子標的治療研究会, Jan. 2011.
1132.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 浅野間理仁 : 脂肪由来幹細胞(ADRCs)の傷害膵島保護作用に関する検討, 第17回外科侵襲とサイトカイン研究会, Dec. 2010.
1133.	斎藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : ヒト脂肪由来幹細胞は肝細胞傷害を軽減する, 第17回外科侵襲とサイトカイン研究会, Dec. 2010.
1134.	斎藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : Catechinは抗酸化作用及び抗炎症左様により大量肝切除後の肝傷害を軽減し肝再生を促進する, 第23回日本バイオセラピィ学会学術集会, Dec. 2010.
1135.	Tomohiko Miyatani, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Hiroki Mori, Jun Hanaoka, 柏原秀也, Chie Mikami and Toru Utsunomiya : 切除不能大腸癌肝転移に対する新規化学療法についての検討, 第94回日本消化器病学会四国支部例会, Dec. 2010.
1136.	山田眞一郎, Mitsuo Shimada, 斎藤裕, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 浅野間理仁 : 脂肪由来幹細胞は液性因子にて肝細胞傷害を軽減する, 第94回日本消化器病学会四国支部例会, Dec. 2010.
1137.	浅野間理仁, Mitsuo Shimada, Hiroki Mori, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 肝硬変症における脾臓の役割, 第94回日本消化器病学会四国支部例会, Dec. 2010.
1138.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : ヒストンアセチル化に基づく消化器癌肝細胞制御の可能性, 第94回日本消化器病学会四国支部例会, Dec. 2010.
1139.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁 and 山田眞一郎 : Bevacizumabの肝切除術後肝再生に与える影響, 第40回日本創傷治癒学会, Dec. 2010.
1140.	Tetsuya Ikemoto, Mitsuo Shimada, Kouzou Yoshikawa, Nobuhiro Kurita, Toru Utsunomiya, Takashi Iwata, Masanori Nishioka, Yuji Morine, Jun Higashijima, Hiroki Mori, Tomohiko Miyatani, Jun Hanaoka and Tomomi Kuwahara : 消化器外科領域における漢方の役割腸管ストレスに対する大建中湯の効果—バクテリアルトランスロケーションからマイクロビオームへ, 第20回外科漢方研究会 (第72回日本臨床外科学会関連会合), Nov. 2010.
1141.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : Stage 4膵癌に対するTJ-48の効果についての検討, 第72回日本臨床外科学会総会, Nov. 2010.
1142.	浅野間理仁, Mitsuo Shimada, Hiroki Mori, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 肝硬変症の脾臓の役割, 第72回日本臨床外科学会総会, Nov. 2010.
1143.	斎藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 肝細胞癌の術後再発予測における術前AFP-L3分画の役割, 第72回日本臨床外科学会総会, Nov. 2010.
1144.	Satoru Imura, Mitsuo Shimada, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 成人生体肝移植施行例の短期成績:特に左葉グラフト肝移植とC型肝硬変に対する血液型不適合肝移植の成績, 第72回日本臨床外科学会総会, Nov. 2010.
1145.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 斎藤裕, 山田眞一郎, 浅野間理仁 and Yoshimi Bando : IPMN悪性度評価におけるJagged 1発現の有用性, 第72回日本臨床外科学会総会, Nov. 2010.
1146.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 肝離断時無血紮手技を用いた肝後区域切除における我々の工夫, 第72回日本臨床外科学会総会, Nov. 2010.
1147.	川下陽一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : 3D volumetryを用いた下右肝静脈径と環流領域容量計測の有用性∼3Dソフト間の比較から∼, 第72回日本臨床外科学会総会, Nov. 2010.
1148.	Hiroki Mori, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Toru Utsunomiya, Hisami Okumura and Eiji Takeda : 肝切除周術期管理としての呼吸商の意義, 第72回日本臨床外科学会総会, Nov. 2010.
1149.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 安全かつ確実な肝葉切除標準化の工夫, 第72回日本臨床外科学会総会, Nov. 2010.
1150.	Toru Utsunomiya, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 切除不能大腸癌肝転移に対する強力な新規抗癌剤・分子標的剤の試み:根治切除を目指して, 第72回日本臨床外科学会総会, Nov. 2010.
1151.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Hidenori Miyake : 鏡視下左肝切除の定型化と肝癌に対する妥当性, 第72回日本臨床外科学会総会, Nov. 2010.
1152.	Satoru Imura, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Mitsuo Shimada : 腹腔鏡下肝葉切除における低侵襲性の検証∼SIRS項目を用いた開腹との比較∼, 第4回肝臓内視鏡外科研究会, Nov. 2010.
1153.	斎藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, 川下陽一郎, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine and Toru Utsunomiya : 癌幹細胞マーカーからみた細胆管細胞癌及び胆管細胞癌の発生, 第21回日本消化器癌発生学会総会, Nov. 2010.
1154.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 免疫学的側面から見たIPMN悪性度上昇に関する検討, 第21回日本消化器癌発生学会総会, Nov. 2010.
1155.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 肝内胆管癌における癌幹細胞を中心とした分子治療の可能性, 第21回日本消化器癌発生学会総会, Nov. 2010.
1156.	Satoru Imura, Mitsuo Shimada, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 肝癌再発形式からみたサルベージ肝移植の可能性, 第21回日本消化器癌発生学会総会, Nov. 2010.
1157.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 斎藤裕, 岩橋衆一, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto and Yuji Morine : 臨床病理学的および分子遺伝学的特徴からみた非B非C型肝癌発生のメカニズム, 第21回日本消化器癌発生学会総会, Nov. 2010.
1158.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka and 金本真美 : Gd-EOB-DTPA造影MRIの肝予備能評価の検討, 第19回日本コンピューター外科学会, Nov. 2010.
1159.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 川下陽一郎, 岩橋衆一 and 斎藤裕 : 3D volumetryを用いた下右肝静脈径と灌流領域容量計測の有用性∼異なる3D画像処理ソフトの比較検討∼, 第19回日本コンピューター外科学会, Nov. 2010.
1160.	川下陽一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 川田祐子 and Hidenori Miyake : 肝転移を伴う大腸癌に対する同時切除の検討, 第48回日本癌治療学会学術集会, Oct. 2010.
1161.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 肝内胆管癌に対する鏡視下肝切除の有用性, 第48回日本癌治療学会学術集会, Oct. 2010.
1162.	山田眞一郎, Mitsuo Shimada, 斎藤裕, 川田祐子, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Shinya Morimoto, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Toru Utsunomiya, Nobuhiro Kurita and Hidenori Miyake : 非B非C型肝癌の臨床的特徴と肝基盤病変の検討, 第48回日本癌治療学会学術集会, Oct. 2010.
1163.	斎藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, 川下陽一郎, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : ヒト脂肪組織由来幹細胞の癌細胞増殖抑制効果の検討, 第48回日本癌治療学会学術集会, Oct. 2010.
1164.	岩橋衆一, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 斎藤裕, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya and Hidenori Miyake : 再発肝癌に対する肝移植の可能性∼Up-to-seven基準での検討∼, 第48回日本癌治療学会学術集会, Oct. 2010.
1165.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁, 山田眞一郎 and Hidenori Miyake : 肝癌切除術後長期(10年以上)生存例の臨床病理学的特徴, 第48回日本癌治療学会学術集会, Oct. 2010.
1166.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 肝内胆管癌における癌幹細胞の意義, 第48回日本癌治療学会学術集会, Oct. 2010.
1167.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 切除不能胆管がんに対するGFP療法の有用性., 第48回日本癌治療学会学術集会, Oct. 2010.
1168.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : 進行肝癌に対する補助療法としてのIFP療法の有用性およびソラフェニブの適応提案, 第48回日本癌治療学会学術集会, Oct. 2010.
1169.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Kouzou Yoshikawa, Yuji Morine, Satoru Imura and Hidenori Miyake : TJ48がStageⅣb膵癌に与える臨床病理学的影響に関する研究, 第48回日本癌治療学会学術集会, Oct. 2010.
1170.	Satoru Imura, Mitsuo Shimada, 山田眞一郎, 浅野間理仁, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 肝切除後，長期生存のための条件およびサルベージ肝移植施行のタイミングの検討, 第48回日本癌治療学会学術集会, Oct. 2010.
1171.	Toru Utsunomiya, Mitsuo Shimada, Yuji Morine, 小松正人, 斎藤裕, Hiroki Mori, Jun Hanaoka, 岩橋衆一, Tetsuya Ikemoto and Satoru Imura : がん幹細胞のepigenetic修飾とがん根治療法への可能性, 第48回日本癌治療学会学術集会, Oct. 2010.
1172.	川下陽一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and Hidenori Miyake : 生体肝移植ドナー手術術前評価における3D-volumetry systemの比較, 第46回日本移植学会総会, Oct. 2010.
1173.	Hiroki Mori, Mitsuo Shimada, 山田眞一郎, 浅野間理仁, 斎藤裕, 岩橋衆一, 杉本光司, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 細胞移植としての脂肪由来幹細胞によるβ細胞置換療法に関する検討, 第46回日本移植学会総会, Oct. 2010.
1174.	Satoru Imura, Mitsuo Shimada, 山田眞一郎, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 再発肝癌に対するサルベージ肝移植の可能性 ∼新旧ミラノ基準での検討∼, 第46回日本移植学会総会, Oct. 2010.
1175.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : C型肝硬変例に対するABO不適合肝移植後のCyAを用いた抗ウイルス療法, 第46回日本移植学会総会, Oct. 2010.
1176.	Tetsuya Ikemoto, Mitsuo Shimada, 松本慎一, 山田眞一郎, 斎藤裕, 岩橋衆一, 杉本光司, Jun Hanaoka, Hiroki Mori, Yuji Morine, Satoru Imura and Toru Utsunomiya : IDO+形質細胞様樹状細胞が誘導する免疫寛容誘導の検討, 第46回日本移植学会総会, Oct. 2010.
1177.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 浅野間理仁 : 過小グラフト回避のための完全左葉グラフト採取手技, 第46回日本移植学会総会, Oct. 2010.
1178.	斎藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, 川下陽一郎, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : E-PASSを用いた急性胆嚢炎術後合併症のリスク評価に関する検討, 第23回日本内視鏡外科学会総会, Oct. 2010.
1179.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 当科における単孔式腹腔鏡下胆嚢摘出術の経験, 第23回日本内視鏡外科学会総会, Oct. 2010.
1180.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Tetsuya Ikemoto, Yuji Morine, 調憲, 武冨紹信 and 前原喜彦 : 腹腔鏡下管切除術の肝内胆管癌症例への展開, 第23回日本内視鏡外科学会総会, Oct. 2010.
1181.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁, 山田眞一郎, Nobuhiro Kurita and Hidenori Miyake : 腹腔鏡下肝葉切除における低侵襲性の検証—SIRS項目を用いた開腹との比較, 第23回日本内視鏡外科学会総会, Oct. 2010.
1182.	西正暁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, Nobuhiro Kurita and Hidenori Miyake : 肝硬変に対する外科的治療, 第14回日本肝臓学会大会 (JDDW日本消化器関連学会集会), Oct. 2010.
1183.	山田眞一郎, Hidenori Miyake, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura and 岩橋衆一 : 超高齢者肝細胞癌に対する肝切除術の妥当性の検討, 第8回日本消化器外科学会 (JDDW日本消化器関連学会集会), Oct. 2010.
1184.	斎藤裕, Mitsuo Shimada, Toru Utsunomiya, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 肝細胞癌に対する新規分子マーカー探索のための非癌部肝組織を用いた網羅的遺伝子発現解析, 第8回日本消化器外科学会 (JDDW日本消化器関連学会集会), Oct. 2010.
1185.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 川田祐子 and Hidenori Miyake : IPMNにおける末梢血中Foxp3と局所IDO陽性細胞の関連に関する検討, 第8回日本消化器外科学会(JDDW日本消化器関連学会集会), Oct. 2010.
1186.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 大腸癌肝転移に対する治療戦略, 第8回日本消化器外科学会 (JDDW日本消化器関連学会集会), Oct. 2010.
1187.	Satoru Imura, Mitsuo Shimada, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 再発肝癌に対するサルベージ肝移植の可能性∼新旧ミラノ基準での検討∼, 第8回日本消化器外科学会 (JDDW日本消化器関連学会集会), Oct. 2010.
1188.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 岩橋衆一, 斎藤裕, 山田眞一郎, 浅野間理仁 and Masafumi Harada : Gd-EOB-DTPA造影MRIを用いた新しい肝予備能評価法の検討, 第5回肝癌治療シミュレーション研究会, Sep. 2010.
1189.	Takashi Iwata, Mitsuo Shimada, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : The growth inhibitory effect of human adipose tissue derived stem cell on pancreas and colon cancer cells. (ヒト脂肪由来肝幹細胞の膵癌，大腸癌細胞増殖抑制効果の検討.), 第69回日本癌学術総会, Sep. 2010.
1190.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁 and 山田眞一郎 : The impact of bevacizumab on liver regeneration following hepatectomy in rats. (ベバシズマブのラット肝切除後の肝再生に与える影響.), 第69回日本癌学会学術総会, Sep. 2010.
1191.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 浅野間理仁 : Indolamine2,3-deoxygenase (ICO) has influences for the aggressiveness of IPMN through Foxp3+Treg in peripheral blood. (IPMN悪性度上昇における末梢血液Treg上昇のindolamine2,3-deoxygenase(IDO)関与に関する検討.), 第69回日本癌学会学術総会, Sep. 2010.
1192.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : Correlation between CD133 and HDAC in cholangiocarcinoma :A possible epigenetic regulation of cancer stem cell. (肝内胆管癌におけるCD133とHDAC発現との関連に関する検討.), 第69回日本癌学会学術総会, Sep. 2010.
1193.	斎藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 山田眞一郎 and 浅野間理仁 : Adipose-derived stem cells differentiate into hepatocytes in regenerating liver after hepatectomy in mice. (マウス切除肝における脂肪由来幹細胞の肝細胞へ分化(予備研究).), 第69回日本癌学会学術総会, Sep. 2010.
1194.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and 斎藤裕 : Histone deacetylase inhibitor enhances anti-tumor effect of gemcitabine through up-regulating of p21 signaling. (ヒストン脱アセチル化学酵素阻害剤によるp21増強を介したGemicitabine抗腫瘍効果増強.), 第69回日本癌学会学術総会, Sep. 2010.
1195.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : Clinicopathological feaures and gene-expression profiles in hepatocellular carcinoma without B or C viral infection. (非B非C肝癌の臨床病理学的および分子遺伝学的特徴に関する検討.), 第69回日本癌学会学術総会, Sep. 2010.
1196.	久山寿子, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroo Takehara and Akira Nii : 膵・胆管合流異常症に関する実験的検討:ラット胆管拡張症モデル, 第33回日本膵・胆管合流異常研究会, Sep. 2010.
1197.	山田眞一郎, Mitsuo Shimada, Yuji Morine, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 久山寿子, 岩橋衆一, 斎藤裕, 浅野間理仁 and Hidenori Miyake : 胆道癌におけるHMGB1発現の意義, 第33回日本膵・胆管合流異常研究会, Sep. 2010.
1198.	久山寿子, Yuji Morine and Mitsuo Shimada : 全国集計からみた非拡張型膵・胆管合流異常の特徴と胆道癌発生頻度, 第33回日本膵・胆管合流異常研究会, Sep. 2010.
1199.	Satoru Imura, Mitsuo Shimada, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 門亢症併存肝癌に対する脾摘+肝癌局所治療の成績∼肝切除前後の脾臓の役割とあわせて∼, 第17回日本門脈圧亢進症学会総会, Sep. 2010.
1200.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁 and 山田眞一郎 : 膵頭十二指腸切除術における逆行性肝胆道ドレナージ(RTBD)の必要性に関する検討, 第85回中国四国外科学会総会/第15回中国四国内視鏡外科研究会, Sep. 2010.
1201.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 当科における単孔式腹腔鏡下胆嚢摘出術の導入, 第85回中国四国外科学会総会/第15回中国四国内視鏡外科研究会, Sep. 2010.
1202.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 斎藤裕, 山田眞一郎 and 浅野間理仁 : 左葉グラフト肝移植における肝静脈再建の工夫∼吻合口拡大のための手技の工夫∼., 第85回中国四国外科学会総会/第15回中国四国内視鏡外科研究会, Sep. 2010.
1203.	山田眞一郎, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕, 浅野間理仁 and Hidenori Miyake : ABO不適合肝移植により救命した亜急性型劇症肝炎症例の経験, 第28回中国四国臨床臓器移植研究会, Aug. 2010.
1204.	斎藤裕, Mitsuo Shimada, Toru Utsunomiya, 浅野間理仁, 山田眞一郎, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : ヒト脂肪由来幹細胞による肝再生促進効果に関する基礎的検討, 第241回徳島医学会学術集会, Aug. 2010.
1205.	Erdenebulgan Batmunkh, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Hiroki Mori, Jun Hanaoka and Shuichi Iwahashi : The correlation between cancer stem like cells and epigenetic alteration in intrahepatic cholangiocarcinoma, 第65回日本消化器外科学会総会, Jul. 2010.
1206.	斎藤裕, Mitsuo Shimada, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 高圧酸素療法(HBO)の肝preconditioning効果(Microarray解析), 第65回日本消化器外科学会総会, Jul. 2010.
1207.	松本早代, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : 切除不能膵癌に対する多剤併用化学療法の有用性の検討, 第65回日本消化器外科学会総会, Jul. 2010.
1208.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and Hidenori Miyake : 大腸癌肝転移治癒切除症例における短期予後の検討∼同時性転移vs異時性転移∼, 第65回日本消化器外科学会総会, Jul. 2010.
1209.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 斎藤裕 and Hidenori Miyake : Gd-EOB-DTPA造影MRIを用いた新しい肝予備能評価法の検討, 第65回日本消化器外科学会総会, Jul. 2010.
1210.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 斎藤裕 and Hidenori Miyake : ミラノ外肝癌切除後の再発様式からみた肝移植適応と補助化学療法としてのIFP療法の有用性, 第65回日本消化器外科学会総会, Jul. 2010.
1211.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 小松正人 and 川田祐子 : 耐糖能傷害に対する脂肪由来幹細胞導入の基礎的検討, 第65回日本消化器外科学会総会, Jul. 2010.
1212.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 川田祐子 : 肝内胆管癌に対する治療戦略-至適術式と非切除例における治療方針, 第65回日本消化器外科学会総会, Jul. 2010.
1213.	Satoru Imura, Mitsuo Shimada, 斎藤裕, 川田祐子, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine and Toru Utsunomiya : 安全な肝葉切除術を目指した術式標準化への工夫, 第65回日本消化器外科学会総会, Jul. 2010.
1214.	Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 川田祐子 and Hidenori Miyake : 切除不能大腸癌転移に対する化学療法後肝切除のタイミングと術式に関する検討, 第65回日本消化器外科学会総会, Jul. 2010.
1215.	斎藤裕, Mitsuo Shimada, 浅野間理仁, 山田眞一郎, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya, Hisami Okumura and Eiji Takeda : 肝傷害患者における術前栄養指標としての呼吸商の意義, 第47回日本外科代謝栄養学会学術集会, Jul. 2010.
1216.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 斎藤裕 : 細胆管癌における癌幹細胞マーカー発現の検討, 第46回日本肝癌研究会, Jul. 2010.
1217.	Tetsuya Ikemoto, Mitsuo Shimada, 斎藤裕, 山田眞一郎, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Satoru Imura, Yuji Morine and Toru Utsunomiya : 進行肝細胞癌に対するソラフェニブの位置づけ, 第46回日本肝癌研究会, Jul. 2010.
1218.	Satoru Imura, Mitsuo Shimada, 斎藤裕, Shuichi Iwahashi, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya, Hidenori Miyake, Katsuyoshi Tamaki and Tetsuji Takayama : HCV関連肝癌治療後の再発予防を目的としたPEG/Rib併用療法の有効性の検討, 第46回日本肝癌研究会, Jul. 2010.
1219.	斎藤裕, Mitsuo Shimada, 川田祐子, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : (症例), 第46回日本肝癌研究会, Jul. 2010.
1220.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 切除不能大腸癌肝転移に対する化学療法後肝切除に関する検討, 第46回日本肝癌研究会, Jul. 2010.
1221.	山田眞一郎, Mitsuo Shimada, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Toru Utsunomiya, Nobuhiro Kurita and Hidenori Miyake : 術式定型化による完全鏡視下肝外側区域切除術, 第46回日本肝癌研究会, Jul. 2010.
1222.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 斎藤裕, 川田祐子 and Masafumi Harada : Gd-EOB-DTPA造影MRIを用いた新しい肝予備能評価法の検討, 第46回日本肝癌研究会, Jul. 2010.
1223.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 斎藤裕, 柏原秀也, 岩橋衆一, Hiroki Mori, Jun Hanaoka, Tetsuya Ikemoto and Yuji Morine : 非B非C型肝癌の臨床病理的および分子遺伝学的特徴, 第46回日本肝癌研究会, Jul. 2010.
1224.	Tomohiko Miyatani, Mitsuo Shimada, Nobuhiro Kurita, Takashi Iwata, Masanori Nishioka, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Shinya Morimoto, Kouzou Yoshikawa, Jun Higashijima, Hiroki Mori, Jun Hanaoka, 柏原秀也, Chie Mikami and Toru Utsunomiya : 切除不能大腸癌肝転移に対する新規化学療法著効後肝切除症例の検討, 第73回大腸癌研究会, Jul. 2010.
1225.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 斎藤裕, 佐々木一, 青沼広光 and 川島昭浩 : 生体肝移植レシピエント術後肝障害に対する高機能流動食MHN02の臨床的効果, 第28回日本肝移植研究会, Jul. 2010.
1226.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 川田祐子, 斎藤裕 and Masafumi Harada : Gd-EOB-DTPA造影MRIを用いた肝不全時の肝予備能の検討, 第28回日本肝移植研究会, Jul. 2010.
1227.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 斎藤裕 and 山田眞一郎 : 生体肝移植後のB型肝炎再発予防の取り組みと課題, 第28回日本肝移植研究会, Jul. 2010.
1228.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 斎藤裕 and 山田眞一郎 : 過小グラフト回避のための完全左葉グラフト採取手技, 第28回日本肝移植研究会, Jul. 2010.
1229.	Satoru Imura, Mitsuo Shimada, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : Up-to-seven基準内外でみた肝癌切除症例の術後成績の検討, 第28回日本肝移植研究会, Jul. 2010.
1230.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 斎藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto and Yuji Morine : C型肝硬変に対するABO不適合肝移植後のlow dose PEG-IFN/RBV療法の有用性, 第28回日本肝移植研究会, Jul. 2010.
1231.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 齋藤裕, 山田眞一郎 and 浅野間理仁 : 進行再発肝癌に対するソラフェニブの使用経験及び著効例の検討., 第2回日本肝がん分子標的治療研究会, Jun. 2010.
1232.	齋藤裕, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka and 岩橋衆一 : IDOを介したIPMN悪性化における末梢血中調節性T細胞上昇の機序解明に関する検討., 第93回日本消化器病学会四国支部例会 / 第104回日本消化器内視鏡学会四国地方会, Jun. 2010.
1233.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一 and 齋藤裕 : 定型化による安全確実な腹腔鏡下左肝切除術., 第93回日本消化器病学会四国支部例会 / 第104回日本消化器内視鏡学会四国地方会, Jun. 2010.
1234.	Toru Utsunomiya, Mitsuo Shimada, 齋藤裕, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine and Satoru Imura : 切除不能大腸癌肝転移に対する外科の進歩:化学療法後肝切除例の検討., 第93回日本消化器病学会四国支部例会 / 第104回日本消化器内視鏡学会四国地方会, Jun. 2010.
1235.	Tetsuya Ikemoto, Mitsuo Shimada, 小松正人, 齋藤裕, Jun Hanaoka, Hiroki Mori, Yuji Morine, Satoru Imura and Toru Utsunomiya : 耐糖能傷害に対する脂肪由来幹細胞導入の基礎的検討., 第93回日本消化器病学会四国支部例会 / 第104回日本消化器内視鏡学会四国地方会, Jun. 2010.
1236.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, 川田祐子, 佐々木一, 青沼広光 and 川島昭浩 : 生体肝移植レシピエント術後肝障害に対する新規高機能流動食MHN-02の効果., 第35回日本外科系連合学会学術集会, Jun. 2010.
1237.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 川田祐子 : 肝内胆管癌に対する治療戦略∼至適術式と非切除例における治療方針∼., 第35回日本外科系連合学会学術集会, Jun. 2010.
1238.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and Hidenori Miyake : 鏡視下肝切除を安全に定型化するための工夫, 第35回日本外科系連合学会学術集会, Jun. 2010.
1239.	Yuji Morine and Mitsuo Shimada : Bacterial translocation (DKT) ., 第61回日本東洋医学学術総会, Jun. 2010.
1240.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 川田祐子 : 進行肝硬変症例に対する脾摘術の功罪., 第46回日本肝臓学会総会, May 2010.
1241.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Akira Nii, Hiroki Mori, 岩橋衆一, 齋藤裕, 川田祐子, 佐々木一, 青沼広光 and 川島昭浩 : 肝温虚血再灌流傷害に対する高機能流動食MEIN®の有用性., 第46回日本肝臓学会総会, May 2010.
1242.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 川田祐子 and Hidenori Miyake : 新規肝予備能評価におけるGd-EOB-DTPA造影MRIの有用性に関する検討., 第46回日本肝臓学会総会, May 2010.
1243.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, Jun Hanaoka and Yuji Morine : 非癌部肝組織の遺伝子発現解析に着目した肝細胞癌分子マーカーの探索., 第46回日本肝臓学会総会, May 2010.
1244.	齋藤裕, Mitsuo Shimada, 川田祐子, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 診断・治療法の選択に苦慮したインスリノーマの一例., 第22回日本肝胆膵外科学会学術集会, May 2010.
1245.	浅野間理仁, Mitsuo Shimada, 川田祐子, 齋藤裕, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Satoru Imura and Toru Utsunomiya : 進行性肝細胞癌に対するソラフェニブの位置付け., 第22回日本肝胆膵外科学会学術集会, May 2010.
1246.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 齋藤裕, 川田祐子, 山田眞一郎 and Hidenori Miyake : 肝内胆管癌におけるHDAC阻害剤の効果の検討., 第22回日本肝胆膵外科学会学術集会, May 2010.
1247.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 川田祐子 and Hidenori Miyake : 肝胆膵高度技能医を目指す若手外科医の膵頭十二指腸切除術., 第22回日本肝胆膵外科学会学術集会, May 2010.
1248.	Satoru Imura, Mitsuo Shimada, 齋藤裕, 川田祐子, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya, Nobuhiro Kurita and Hidenori Miyake : 腹腔鏡下肝切除の術式定型化に必要なもの∼合併症対策と開腹手術手技の応用∼., 第22回日本肝胆膵外科学会学術集会, May 2010.
1249.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 川田祐子 : 新規化学療法により切除可能となった両葉多発性肝転移症例の経験., 第22回日本肝胆膵外科学会学術集会, May 2010.
1250.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 川田祐子 and Hidenori Miyake : 安全確実な拡大肝左葉切除標準化の工夫., 第22回日本肝胆膵外科学会学術集会, May 2010.
1251.	Satoru Imura, Mitsuo Shimada, 齋藤裕, 川田祐子, 岩橋衆一, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya, Nobuhiro Kurita and Hidenori Miyake : 肝胆膵外科高度技能医を目指す若手外科医の肝臓手術∼グリソン一括処理による肝右葉切除術∼., 第22回日本肝胆膵外科学会学術集会, May 2010.
1252.	Toru Utsunomiya, Mitsuo Shimada, Jun Hanaoka, Satoru Imura, 齋藤裕, 川田祐子, 岩橋衆一, Hiroki Mori, Tetsuya Ikemoto and Yuji Morine : Gd-EOB-DTPA造影MRIを用いた新規肝予備能評価法に関する検討., 第22回日本肝胆膵外科学会学術集会, May 2010.
1253.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 川田祐子 : エコーガイド下グリソン先行遮断による系統的縮小肝切除術., 第64回手術手技研究会, May 2010.
1254.	Hiroki Mori, Mitsuo Shimada, Satoru Imura, 齋藤裕, 川田祐子, 岩橋衆一, Jun Hanaoka, Tetsuya Ikemoto, Yuji Morine, Toru Utsunomiya and Hidenori Miyake : 肝移植後の再発肝癌に対する治療戦略と肝移植後Follow upの問題点., 第96回日本消化器病学会総会, Apr. 2010.
1255.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, 岩橋衆一, 齋藤裕, 川田祐子 and Masafumi Harada : Gd-EOB-DTPA造影MRI肝細胞造影相における造影効果と99mTc-GSAの相関に関する検討., 第96回日本消化器病学会総会, Apr. 2010.
1256.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 肉眼的脈管侵襲陽性肝癌に対するIFP療法の効果および切除不能肝癌に対するソラフェニブの使用経験., 第96回日本消化器病学会総会, Apr. 2010.
1257.	岩橋衆一, Mitsuo Shimada, Yuji Morine, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : StageIVb進行胆嚢癌に対する集学的治療戦略., 第96回日本消化器病学会総会, Apr. 2010.
1258.	Tetsuya Ikemoto, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Hiroki Mori, Jun Hanaoka, 岩橋衆一, 齋藤裕 and 川田祐子 : IPMNに対するFoxp3+CD4+CD25+細胞による手術適応と予後に関する研究., 第96回日本消化器病学会総会, Apr. 2010.
1259.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, 小松正人, 岩橋衆一, 齋藤裕 and 川田祐子 : 肝内胆管癌の治療戦略における癌幹細胞の意義., 第96回日本消化器病学会総会, Apr. 2010.
1260.	Akira Nii, Mitsuo Shimada, Hiroo Takehara, 久山寿子, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 川田佑子, 齋藤裕, Nobuhiro Kurita and Hidenori Miyake : MHN-02を介してUCP-2Severe NAFL model rat における虚血再灌流を改善する(第2報), 第110回日本外科学会定期学術集会, Apr. 2010.
1261.	久山寿子, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Nobuhiro Kurita, Hidenori Miyake, Akira Nii and Hiroo Takehara : 膵・胆管合流異常症に関する実験的検討:ラット胆管拡張モデル, 第110回日本外科学会定期学術集会, Apr. 2010.
1262.	Chie Mikami, Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 斎藤裕, 岩橋衆一, Jun Hanaoka, 金本真美, Tetsuya Ikemoto, Yuji Morine, Hidenori Miyake and Nobuhiro Kurita : 非癌部肝組織におけるstathmin1遺伝子発現解析による肝切除後多中心性再発の予測, 第110回日本外科学会定期学術集会, Apr. 2010.
1263.	和田佑馬, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 非B非C肝癌におけるメタボリック症候群., 第110回日本外科学会定期学術集会, Apr. 2010.
1264.	片山智博, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Hidenori Miyake and Nobuhiro Kurita : 細胆管癌・混合型肝癌における癌幹細胞マーカー発現の検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1265.	甲斐田剛圭, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 生体肝移植ドナーにおける肝鬱血領域の与える影響., 第110回日本外科学会定期学術集会, Apr. 2010.
1266.	浅野間理仁, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 肝内胆管癌における癌幹細胞の存在と発現意義., 第110回日本外科学会定期学術集会, Apr. 2010.
1267.	齋藤裕, Mitsuo Shimada, Tetsuya Ikemoto, 杉本光司, 岩橋衆一, 川田祐子, Jun Hanaoka, 金本真美, Yuji Morine, Satoru Imura, Toru Utsunomiya, Nobuhiro Kurita, Hidenori Miyake and 松本慎一 : IDO+樹状細胞が誘導する調節生T細胞を用いた免疫寛容誘導の機序解明., 第110回日本外科学会定期学術集会, Apr. 2010.
1268.	川田祐子, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, Nobuhiro Kurita and Hidenori Miyake : CTを用いた内臓脂肪量測定値が肝切除術に対して与える影響の検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1269.	岩橋衆一, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 齋藤裕, 川田祐子, Hidenori Miyake and Nobuhiro Kurita : ヒストン脱アセチル化酵素阻害剤による胆管癌細胞株に対するGemcitabine併用化学療法増強効果の検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1270.	徳永卓哉, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Hidenori Miyake and Nobuhiro Kurita : ヒストン脱アセチル化酵素阻害剤による膵癌細胞株に対するGemcitabine及びinterferon-α併用化学療法増強効果の検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1271.	杉本光司, Mitsuo Shimada, Tetsuya Ikemoto, 川田祐子, 齋藤裕, 岩橋衆一, Jun Hanaoka, Yuji Morine, Satoru Imura, Toru Utsunomiya and 花本慎一 : アメリカ・日本間の国際膵島輸送に関する検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1272.	金本真美, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 岩橋衆一, 齋藤裕, Hidenori Miyake and Nobuhiro Kurita : 閉塞性黄疸患者における因蔯嵩湯の効果., 第110回日本外科学会定期学術集会, Apr. 2010.
1273.	Jun Hanaoka, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, 岩橋衆一, 齋藤裕, Hidenori Miyake, Nobuhiro Kurita and 原田雅文 : Gd-EOB-DTPA造影MRI肝細胞造影相における造影効果と肝アシアロシンチグラフィーの相関に関する検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1274.	荒川悠佑, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, 金本真美, Jun Hanaoka, 杉本光司, 岩橋衆一, 齋藤裕, Nobuhiro Kurita and Hidenori Miyake : 膵頭十二指腸切除術におけるExternal stent (RTBD)の必要性に関する検討(RCT)., 第110回日本外科学会定期学術集会, Apr. 2010.
1275.	篠原永光, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, Hiroki Mori, 岩橋衆一, 齋藤裕, 川田祐子, Hidenori Miyake and Nobuhiro Kurita : 大腸癌肝転移に対する新規化学療法著効後肝切除例の検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1276.	Tetsuya Ikemoto, Mitsuo Shimada, 川田祐子, 岩畔英樹, 齋藤裕, 小松正人, 金本真美, Jun Hanaoka, Yuji Morine, Satoru Imura and Toru Utsunomiya : 糖能傷害に対する脂肪由来幹細胞導入の基礎的検討., 第110回日本外科学会定期学術集会, Apr. 2010.
1277.	Yuji Morine, Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 小松正人, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 肝内胆管癌における癌幹細胞の発現意義と治療戦略としての可能性., 第110回日本外科学会定期学術集会, Apr. 2010.
1278.	Satoru Imura, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 定型化による安全確実な腹腔鏡下左肝切除術., 第110回日本外科学会定期学術集会, Apr. 2010.
1279.	寺澤敏秀, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Hidenori Miyake and Nobuhiro Kurita : 胆嚢癌におけるThrombospondin1発現の意義., 第110回日本外科学会定期学術集会, Apr. 2010.
1280.	Hidenori Miyake, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 斎藤裕, 川田祐子 and Nobuhiro Kurita : 胆道癌におけるHMGB1発現の意義., 第110回日本外科学会定期学術集会, Apr. 2010.
1281.	Hiroki Mori, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, 川田祐子, Nobuhiro Kurita and Hidenori Miyake : 生体肝移植ドナーにおける門脈血流支配領域を考慮した完全左葉グラフト採取手技., 第110回日本外科学会定期学術集会, Apr. 2010.
1282.	Toru Utsunomiya, Mitsuo Shimada, Satoru Imura, 齋藤裕, 川田祐子, 岩橋衆一, Jun Hanaoka, 金本真美, Tetsuya Ikemoto and Yuji Morine : エコーガイド下グリソン先行遮断による合理的な肝細胞癌に対する系統的縮小肝切除術., 第110回日本外科学会定期学術集会, Apr. 2010.
1283.	松本規子, Mitsuo Shimada, Toru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Jun Hanaoka, 金本真美, 岩橋衆一, 齋藤裕, Nobuhiro Kurita and Hidenori Miyake : 黄疸肝における肝・脾臓内遺伝子発現の変化., 第110回日本外科学会定期学術集会, Apr. 2010.
1284.	西正暁, Toru Utsunomiya, Mitsuo Shimada, 齋藤裕, 岩橋衆一, Jun Hanaoka, 金本真美, Tetsuya Ikemoto, Yuji Morine, Hidenori Miyake and Nobuhiro Kurita : 肝細胞癌におけるIFI27遺伝子発現の臨床病理学的特徴., 第110回日本外科学会定期学術集会, Apr. 2010.
1285.	Mitsuo Shimada, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto and Shinya Morimoto : 肝細胞癌の長期生存を得るためのベストチョイスは何か?, 第110回日本外科学会定期学術集会, Apr. 2010. (Keyword) 学会
1286.	Masahiko Fujii, Satoru Imura, Yuji Morine, 池本哲也, Yuji Soejima and Mitsuo Shimada : 肝右葉切除における機会吻器を用いた安全なGlisson 鞘一括処理, 第60回日本消化器外科学会総会, Jul. 2005.
1287.	Masahiko Fujii, Satoru Imura, Yuji Morine, 池本哲也, Yuji Soejima and Mitsuo Shimada : B型肝炎合併肝細胞癌に対する生体肝移植, 第83回日本消化器病学会四国支部例会, Jun. 2005.
1288.	Masahiko Fujii, Satoru Imura, Yuji Morine, 池本哲也 and Mitsuo Shimada : Small-for-size graft における肝不全の病態と対策, 第17回日本肝胆膵外科学会, Jun. 2005.
1289.	Masahiko Fujii, 安藤勤, Satoru Imura, Yuji Morine, 西岡将規, 池本哲也 and Mitsuo Shimada : 大腸癌肝転移に対する外科的治療の意義, 第41回日本肝癌研究会, Jun. 2005.
1290.	Masahiko Fujii, Yuji Morine, Satoru Imura, 池本哲也, Seiki Tashiro, 寺澤敏秀, 三宅秀則 and Mitsuo Shimada : ss胆嚢癌に対する至適術式としてのS4a+S5区域切除術, 第105回日本外科学会総会, May 2005.
1291.	Masahiko Fujii, Yuji Morine, Satoru Imura, 篠原永光 and Mitsuo Shimada : 高度血管侵襲陽性肝細胞癌に対する治療戦略, 第66回日本臨床外科学会総会, Oct. 2004.
1292.	Masahiko Fujii, Yuji Morine, Satoru Imura, 篠原永光 and Mitsuo Shimada : 肝細胞癌に対する生体肝移植の現状と展望, 第22回中四国臨床臓器移植研究会, Aug. 2004.
1293.	Masahiko Fujii, Yuji Morine, Satoru Imura, 篠原永光 and Mitsuo Shimada : 肝細胞癌に対する生体肝移植の現状と展望, 第81回日本消化器病学会四国支部例会, Jun. 2004.

Et cetera, Workshop:

1.	Toshiaki Yoshimoto, Yukako Takehara, Hideya Kashihara, Chie Takasu, Masaaki Nishi, Takuya Tokunaga, Tomohiko Miyatani, Kouzou Yoshikawa, Yuji Morine and Mitsuo Shimada : LED 光による新たな癌制御法の開発, 第261 回徳島医学会学術集会(令和 2 年度夏期), Aug. 2020.
2.	Toshiaki Yoshimoto, Yuji Morine, Kouzou Yoshikawa, Masatake Akutagawa, Takahiro Emoto, Mitsuo Shimada and Yohsuke Kinouchi : Blue light emitting diodeによる大腸癌増殖制御効果, LED総合フォーラム2020 in 徳島, 129-130, Feb. 2020.
3.	Yuji Morine, Kouzou Yoshikawa, Masatake Akutagawa, Takahiro Emoto, Mitsuo Shimada and Yohsuke Kinouchi : Cliical impact of light emittng diode on digestive diseases, IEICE Technical Report (MBE), Vol.117, No.165, 1-6, Jul. 2017. (Keyword) LED / digestive cancer / regenerative medicine / photoreceptor
4.	Yu Saitou, Sonoko Yasui, 吉川雅登, 寺奥大貴, 山田眞一郎, Shuichi Iwahashi, Mami Kanamoto, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yasuhiro Hamada and Mitsuo Shimada : InBodyを用いた体組成分析の肝胆膵外科手術における周術期栄養評価の有用性に関する検討, 第249回徳島医学会学術集会, Jul. 2014.
5.	Mami Kanamoto, Yasuhiro Hamada, Yutaka Nakaya, Eiji Takeda, Hisami Okumura, Toru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori and Mitsuo Shimada : NST介入による周術期栄養管理の有用性に関する検討, Journal of Japan Surgical Society, Vol.115, No.2, 782, Mar. 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573105977706375936 (CiNii: 1573105977706375936)

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

腫瘍微小環境におけるexosomal micro RNA-Nrf2 addictionの機序解明と治療法の確立 (Project/Area Number: 23K08072 )
脂肪由来幹細胞ADSCから誘導した肝細胞様細胞HLCの免疫原性獲得に関する研究 (Project/Area Number: 23K08028 )
オルガノイドを用いた脂肪由来幹細胞からの超高機能肝細胞様細胞の確立 (Project/Area Number: 23K24395 )
Nrf2を介したTAM-cancerクロストークによる肝癌薬剤耐性機序の解明 (Project/Area Number: 22K08753 )
NASHにおける肝転移抑制の機序解明に関する研究 (Project/Area Number: 22K08752 )
自己脂肪由来インスリン産生細胞自家移植における抗原性発現と細胞運命の研究 (Project/Area Number: 22K08734 )
膵・胆管合流異常におけるNrf2 addictionを介した間質反応の解明 (Project/Area Number: 21K08671 )
肝星細胞制御による薬剤耐性肝癌の肝内転移抑制機構の解明 (Project/Area Number: 21K08620 )
Treatment strategy for tumor microenviroment focused on tumor associated macrophage (Project/Area Number: 20K08957 )
Effects of light-emitting diode irradiation on hepatic differentiation of hepatocyte-like cells (Project/Area Number: 20K08928 )
Mechanism of recurrence progression after hepatectomy in non-alcoholic steatohepatitis (Project/Area Number: 19K09095 )
Role of Nrf2 signaling in development of hepatocyte like cells (Project/Area Number: 19K09094 )
SDF-1 after preoperative CRT is associated with prognosis in advanced rectal cancer (Project/Area Number: 19K09071 )
Evaluation for the maturation of insulin-producing cells differentiated from ADSC by the methylation status (Project/Area Number: 19K09045 )
Mechanism of suppressive effect for intrahepatic recurrence of hepatocellular carcinoma by hepatic stellate cell regulation after liver transplantation (Project/Area Number: 18K08573 )
Development of integrated treatment for impaired liver regeneration on non-alcoholic steatohepatitis (Project/Area Number: 18H02871 )
Clarification on mechanism of carcinogenesis for pediatric congenital biliary dilatation (Project/Area Number: 17K11510 )
Effective differentiation of insulin-producing cell from ADSC with three dimensional culture method (Project/Area Number: 16K10429 )
Functional liver tissue rebuilding with bile duct structure on heterotopic transplantation (Project/Area Number: 16K10428 )
Immune response mediated by hepatic stellate cells with endoplasmic reticulum stress in liver transplantation. (Project/Area Number: 15K10027 )
A study about a novel influence and elucidation of Bevacizumab, molecular targeted drug, on liver regeneration after massive hepatectomy (Project/Area Number: 26461913 )
Study on international sense upbringing of overseas interchange program in Clinical Skills Laboratory. (Project/Area Number: 26460603 )
Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction. (Project/Area Number: 26293288 )
A study on the role of the spleen in liver carcinogenesis (Project/Area Number: 25893156 )
The role of unfolded protein response on hepatic stellate cell in old liver ischemia reperfusion injury and liver regeneration (Project/Area Number: 25861194 )
The basic research for establishment of a new strategy for IBMIR control in islet transplantation by ADSC (Project/Area Number: 25462114 )
Mechanism of host organs and tumor microenvironment that related tumor recurrence after liver transplantation (Project/Area Number: 25462092 )
Regulation of aged liver regenerative disorder focused of epigenetic changes (Project/Area Number: 25462091 )
study about a novel elucidation of endoplasmic reticulum stress response on ischemia/reperfusion injury and liver regeneration after massive hepatectomy and living donor liver transplantation (Project/Area Number: 24791426 )
The possible mechanism on homing effect of adipose-derived stem cells to the injured liver (Project/Area Number: 24659611 )
肝発癌分子機構におけるがん幹細胞関連ｍｉＲＮＡ発現の関与 (Project/Area Number: 24592003 )
Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation. (Project/Area Number: 23390324 )
The study to clarify a mechanism of replacing growth of the hepatocellular carcinoma using the adipose tissue derived stem cells (Project/Area Number: 22659243 )
The possibility of hepatic regenerative medicine usingadipose tissue-derived mesenchymal stem cell (ADRC) (Project/Area Number: 22591506 )
Mechanism of recurrence in hepatocel lular carcinoma after livertransplantation (Project/Area Number: 21791292 )
Expression of sonic hedgehog signaling for regulation of liver regeneration after massive hepatectomy of the rat liver (Project/Area Number: 20790958 )
脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発 (Project/Area Number: 20390359 )
細胞の冬眠タンパク誘導を利用した新たな肝保存装置の開発 (Project/Area Number: 19659342 )
Prevention of hepatocellular carcinoma recurrence after livertransplantation by managing regulatory T cells (Project/Area Number: 19591484 )
Development of measurement for hepatic isc hemia-repetfusion in jiry accoidirg to are gulation of activin-follistin system (Project/Area Number: 18591516 )
光触媒作用を応用した新たな人工肝補助装置の開発 (Project/Area Number: 17659390 )
The investigation of regulatory mechanism on liver regeneration after massive hepatectomy (Project/Area Number: 17591408 )
The strategies for overcoming the graft dysfunction after liver transplantation using small-for-size graft (Project/Area Number: 17390370 )
Search by Researcher Number (60398021)

Associate Professor : Morine, Yuji

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Et cetera, Workshop:

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)