徳島大学 / 教育研究者総覧 --- 関根一光

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https://researchmap.jp/1976_SKNKZMT (researchmap)

専門分野

○	歯学 (Dentistry)

研究テーマ

○

著書・論文

学術論文(審査論文):

1.	Adityakrisna Putra Yoshi Wigianto, Yuichi Ishida, Yuki Iwawaki, Takaharu Goto, Megumi Watanabe, Kazumitsu Sekine, Kenichi Hamada, Keiji Murakami, Hideki Fujii and Tetsuo Ichikawa : 2-methacryloyloxyethyl phosphorylcholine polymer treatment prevents Candida albicans biofilm formation on acrylic resin, Journal of Prosthodontic Research, Vol.67, No.3, 384-391, 2022. (要約) We aimed to evaluate the effectiveness of photoreactive 2-methacryloyloxyethyl phosphorylcholine (MPC) in inhibiting Candida albicans biofilm formation on polymethyl methacrylate (PMMA) and assess its mechanism and need for re-application by evaluating its interaction with salivary mucin and durability during temperature changes. PMMA discs were used as specimens. The MPC coating was applied using the spray and cure technique for the treatment groups, whereas no coating was applied to the control. The MPC treatment (MT) groups were further differentiated based on the number of thermal cycles involved (0, 1000, 2500, and 5000). The optical density was measured to assess mucin adsorption (MA). Contact angle (CA) was calculated to evaluate surface hydrophilicity. The presence of MPC components on the PMMA surface was assessed using X-ray photoelectron spectroscopy (XPS). C. albicans biofilms were evaluated qualitatively (scanning electron microscope images) and quantitatively (colony-forming units (CFUs)). Statistical analysis was conducted using two-way analysis of variance and Tukey's multiple comparison test. MA rate and CA increased significantly in the MT groups, which exhibited significantly fewer CFUs and thinner biofilms than those of the control group. Based on the XPS, MA, and CFU evaluations, the durability and efficacy of the MPC coating were considered stable up to 2500 thermal cycles. Additionally, a significant interaction was observed between mucin concentration and MPC efficacy. The photoreactive MPC coating, which was resistant to temperature changes for approximately 3 months, effectively prevented C. albicans biofilm formation by modifying surface hydrophilicity and increasing mucin adsorption. (キーワード) Candida albicans / Acrylic Resins / Polymers / Polymethyl Methacrylate / Surface Properties / Biofilms / Mucins (徳島大学機関リポジトリ) ● Metadata: 119402 (出版サイトへのリンク) ● Publication site (DOI): 10.2186/jpr.JPR_D_22_00102 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36288959 ● Summary page in Scopus @ Elsevier: 2-s2.0-85166383313 (徳島大学機関リポジトリ: 119402, DOI: 10.2186/jpr.JPR_D_22_00102, PubMed: 36288959, Elsevier: Scopus)
2.	Yuta Matsuki, Hiroko Sato, N Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada : Effect of immersion in NaCl solution on the electrical conductivity and the reduction of the shear bond strength of resin-modifi ed glass-ionomer-cements after current application, Dental Materials Journal, Vol.41, No.3, 487-494, 2022. (徳島大学機関リポジトリ) ● Metadata: 117038 (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2021-322 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35264547 ● Search Scopus @ Elsevier (PMID): 35264547 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2021-322 (徳島大学機関リポジトリ: 117038, DOI: 10.4012/dmj.2021-322, PubMed: 35264547)
3.	Eiji Okamoto, Tetsuya Yano, Kazumitsu Sekine, Yusuke Inoue and Yasuyuki Shiraishi : Development and initial performance of a miniature axial flow blood pump using magnetic fluid shaft seal, Journal of Artificial Organs, Vol.26, No.1, 12-16, 2022. (要約) In this study, we developed a new catheter-mounted micro-axial flow blood pump (MFBP) using a new miniature magnetic fluid shaft seal (MFSS). The prototype of the catheter-mounted MFBP had a maximum diameter of 8 mm and a length of 50 mm. The new MFSS composed a neodymium magnet ring, an iron ring, and a magnetic fluid particularly designed for the MFSS. The new MFSS had outer and inner diameters of 4.0 mm and 2.6 mm, respectively, and a length of 3.0 mm. The sealing pressure of the MFSS was calculated to be 432 mmHg using FEM (Finite Element Method) result; therefore, the MFSS had sufficient sealing pressure for the catheter-mounted MFBP. The friction loss of the MFSS included the friction owing to the viscosity of the magnetic fluid and the magnetic force between the iron ring and ring magnet. The total friction loss of the MFSS was 0.08-0.09 W in the pump operational speed range from 22,000 to 35,000 rpm. From the in vitro experimental results, the catheter-mounted MFBP using the MFSS had a pump output of 3 L/min. against a differential pressure of 60 mmHg, and the pump characteristics of the MFBP were almost the same as those of Impella 5.0. (キーワード) Heart-Assist Devices / Magnetics / Catheters / Magnetic Phenomena / Equipment Design (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10047-022-01330-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35426584 ● Search Scopus @ Elsevier (PMID): 35426584 ● Search Scopus @ Elsevier (DOI): 10.1007/s10047-022-01330-7 (DOI: 10.1007/s10047-022-01330-7, PubMed: 35426584)
4.	Muneyuki Yoshimura, Emi Takegawa, Kazumitsu Sekine, Shinya Horiuchi, Eiji Tanaka and Kenichi Hamada : Volume Magnetic Susceptibility Estimation of α- and β-Phases in Titanium Alloys for Biomedical Applications., Journal of Oral Health and Biosciences, Vol.34, No.2, 34-39, 2022. (要約) Metallic medical devices in the human body cause serious artifacts in magnetic resonance imaging owing to the volume magnetic susceptibility (χν) mismatch between the device and tissue around the device. To reduce artifacts, medical devices produced from alloys with χν values of approximately -9 × 10-6 are required. Controlling the phase constitution is a basic technique used to control the χν value of an alloy, and the χν value of each phase is a fundamental property. In this study, an α+β-type Ti alloy and two β-type Ti alloys were investigated. The estimated χν values of the α-phase of the alloys were similar to or smaller than that of pure Ti. In contrast, the estimated χν values of the β-phase of the alloys were larger than that of pure Ti. Since the χν value of pure Ti is much larger than -9 × 10-6, the χν values of the β-phases suggested that increasing the volume fraction of the β-phase was not appropriate for producing a Ti alloy with a lower χν value. (キーワード) Volume magnetic susceptibility / Phase constitution / Heat treatment / Ti-6Al-4V alloy / Ti-Mo alloy (徳島大学機関リポジトリ) ● Metadata: 116783 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.34.2_34 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.34.2_34 (徳島大学機関リポジトリ: 116783, DOI: 10.20738/johb.34.2_34)
5.	Huijiao Yan, Masamitsu Ohshima, Raju Raju, S Raman, Kazumitsu Sekine, Arief Waskitho, Miho Inoue, Masahisa Inoue, Otto Baba, Tsuyoshi Morita, Mayu Miyagi and Yoshizo Matsuka : Dentin-pulp complex tissue regeneration via three-dimensional cell sheet layering, Tissue Engineering. Part C, Methods, Vol.27, No.10, 559-570, 2021. (要約) The dentin-pulp complex is a unique structure in teeth that contains both hard and soft tissues. Generally, deep caries and trauma cause damage to the dentin-pulp complex, and if left untreated, this damage will progress to irreversible pulpitis. The aim of this study was to fabricate a layered cell sheet composed of rat dental pulp (DP) cells and odontogenic differentiation of pulp (OD) cells and to investigate the ability to regenerate the dentin-pulp complex in a scaffold tooth. We fabricated two single cell sheets composed of DP cells (DP cell sheet) or OD cells (OD cell sheet) and a layered cell sheet made by layering both cells. The characteristics of the fabricated cell sheets were analyzed using light microscopy, scanning electron microscope (SEM), hematoxylin-eosin (HE) staining, and immunohistochemistry (IHC). Furthermore, the cell sheets were transplanted into the subrenal capsule of immunocompromised mice for 8 weeks. After this, the regenerative capacity to form dentin-like tissue was evaluated using micro-computed tomography (micro-CT), HE staining, and IHC. The findings of SEM and IHC confirmed that layered cell sheets fabricated by stacking OD cells and DP cells maintained their cytological characteristics. Micro-CT of layered cell sheet transplants revealed a mineralized capping of the access cavity in the crown area, similar to that of natural dentin. In contrast, the OD cell sheet group demonstrated the formation of irregular fragments of mineralized tissue in the pulp cavity, and the DP cell sheet did not develop any hard tissue. Moreover, bone volume/tissue volume (BV/TV) showed a significant increase in hard tissue formation in the layered cell sheet group compared with that in the single cell sheet group ( < 0.05). HE staining also showed a combination of soft and hard tissue formation in the layered cell sheet group. Furthermore, IHC confirmed that the dentin-like tissue generated from the layered cell sheet expressed characteristic markers of dentin but not bone equivalent to that of a natural tooth. In conclusion, this study demonstrates the feasibility of regenerating dentin-pulp complex using a bioengineered tissue designed to simulate the anatomical structure. Impact statement The dentin-pulp complex can be destroyed by deep caries and trauma, which may cause pulpitis and progress to irreversible pulpitis, apical periodontitis, and even tooth loss. Current treatments cannot maintain pulp health, and teeth can become brittle. We developed a three-dimensional (3D) layered cell sheet using dental pulp cells and odontogenic differentiation of pulp cells for dentin-pulp complex regeneration. Our layered cell sheet enables the regeneration of an organized 3D dentin-pulp-like structure comparable with that of natural teeth. This layered cell sheet technology may contribute to dentin-pulp complex regeneration and provide a novel method for complex tissue engineering. (徳島大学機関リポジトリ) ● Metadata: 117029 (出版サイトへのリンク) ● Publication site (DOI): 10.1089/ten.TEC.2021.0171 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34583551 ● Search Scopus @ Elsevier (PMID): 34583551 ● Search Scopus @ Elsevier (DOI): 10.1089/ten.TEC.2021.0171 (徳島大学機関リポジトリ: 117029, DOI: 10.1089/ten.TEC.2021.0171, PubMed: 34583551)
6.	Hiroko Sato, Yuta Matsuki, N Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada : Effects of water immersion on shear bond strength reduction after current application of resin-modified glass-ionomer-cements containing and not containing an ionic liquid., Dental Materials Journal, Vol.40, No.1, 35-43, 2021. (要約) The enhancement in the bonding strength of advanced dental cements has enabled long-lasting dental restorations. However, the high bonding strength can cause difficulty in removing these restorations. Therefore, "smart" dental cements with simultaneous strong bonding and easy on-demand debonding ability are required. A resin-modified glass-ionomer-cement (RMGIC) with an ionic liquid (IL) has demonstrated significant reduction in the bonding strength with current application (CA). This research investigates the effect of immersion in distilled water on the electric conductivity and bonding strength of RMGIC with and without an IL and CA. The RMGIC without the IL exhibited significant electric conductivity after immersion, and a significant decrease in bonding strength with CA. In comparison, the electric conductivity after immersion and the decrease in bonding strength with CA were greater for RMGIC with the IL. Thus, the feasibility of smart dental cements capable of electrically debonding-on-demand is indicated. (キーワード) Electric conductivity / Glass-ionomer-cement / Ionic-liquid / Shear bonding strength / Smart adhesive (徳島大学機関リポジトリ) ● Metadata: 114725 (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2019-371 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32779608 ● Search Scopus @ Elsevier (PMID): 32779608 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.2019-371 (徳島大学機関リポジトリ: 114725, DOI: 10.4012/dmj.2019-371, PubMed: 32779608)
7.	Yeeun Kim, Jiyon Be, Emi Takegawa, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of zirconia additives on β-tricalcium-phosphate cement for high strength and high injectability, Ceramics International, Vol.47, No.2, 1882-1890, 2021. (徳島大学機関リポジトリ) ● Metadata: 116056 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ceramint.2020.09.017 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ceramint.2020.09.017 (徳島大学機関リポジトリ: 116056, DOI: 10.1016/j.ceramint.2020.09.017)
8.	Kazumitsu Sekine and Yoshinori Mitamura : Evaluation of the Cytotoxicity of Oil-Based Magnetic Fluid Based on Cell Proliferation Study, Journal of the Chinese Society of Mechanical Engineers, Transactions of the Chinese Institute of Engineers, Series C, Vol.41, No.5, 647-652, 2020. (要約) Medical applications of magnetic fluids (MFs) have attracted much interest due to the liquid's unique properties. Non-toxicity is important for clinical applications of MFs. Cytotoxicity of MFs has been studied, but previous studies on cytotoxicity of MFs were limited to water-based MFs. We have developed new oil-based MFs specialized for the MF seal in a blood pump. The cytotoxicity of newly developed oil-based MFs was evaluated by cell proliferation and LDH (lactate dehydrogenase) assays. The cell proliferation ratio against the negative control decreased on Day 2 of cell incubation, but increased to the negative control level on Day 6. LDH cytotoxicity was about 10% on Day 6. In conclusion the new oil-based magnetic fluids have low levels of cytotoxicity. (出版サイトへのリンク) ● Publication site (DOI): 10.29979/JCSME (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.29979/JCSME (DOI: 10.29979/JCSME)
9.	Yoshinori Mitamura, Kazumitsu Sekine and Eiji Okamoto : Magnetic fluid seals working in liquid environments: Factors limiting their life and solution methods, Journal of Magnetism and Magnetic Materials, Vol.500, 166293-166297, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jmmm.2019.166293 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmmm.2019.166293 (DOI: 10.1016/j.jmmm.2019.166293)
10.	Kazumitsu Sekine : Development of structural and chemical enforcement of neointimal growth as the blood contacting surface for the vascular prosthesis, The International Journal of Artificial Organs, Vol.41, 606, 2018.
11.	Noboru Kajimoto, Emi Takegawa, Kazumitsu Sekine and Kenichi Hamada : Electrical shear bonding strength reduction of resin-modified glass-ionomer-cement containing ionic-liquid concept and validation of a smart dental cement debonding-on-demand, Dental Materials Journal, Vol.37, No.5, 768-774, 2018. (要約) With improvement of bonding strength of recent dental cement, it is difficult nowadays to remove restorations without excessive force or vibration to tooth, occasionally resulting in damage of dentin, enamel, and dental root. Therefore, "smart" dental cement indicating strong bonding and easy debonding-on-demand simultaneously is required. In this research, resin-modified glass-ionomer-cement containing an ionic-liquid, tris(2-hydroxyethyl)methylammonium methylsulfate was produced, and the shear bonding strength before and after direct current application were evaluated. The prototype cement containing 15 to 20 mass% ionic-liquid indicated simultaneously no significant reduction of shear bonding strength from that of the original cement not containing ionic-liquid, and significant reduction of bonding strength to approximately 20% of that of the original cement after direct current application of more than 2 mmC/mm. The prototype cement in this research demonstrated that the concept of smart dental cement electrically debonding-on-demand is feasible. (徳島大学機関リポジトリ) ● Metadata: 111728 (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2017-361 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29848856 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056973389 (徳島大学機関リポジトリ: 111728, DOI: 10.4012/dmj.2017-361, PubMed: 29848856, Elsevier: Scopus)
12.	Yumika Ida, Jiyon Be, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of powder-to-liquid ratio on properties of β-tricalcium-phosphate cements modified using high-energy ball-milling, Dental Materials Journal, Vol.36, No.5, 590-599, 2017. (要約) The authors have developed a β-tricalcium-phosphate (β-TCP) powder modified mechano-chemically through the application of a ball-milling process (mβ-TCP). The resulting powder can be used in a calcium-phosphate-cement (CPC). In this study, the effects of the powder-to-liquid ratio (P/L ratio) on the properties of the CPCs were investigated, and an appropriate P/L ratio that would simultaneously improve injectability and strength was clarified. The mβ-TCP cement mixed at a P/L ratio of 2.5 and set in air exhibited sufficient injectability until 20 min after mixing, and strength similar to or higher than that mixed at a P/L ratio of 2.0 and 2.78. Although the mβ-TCP cements set in vivo and in SBF were found to exhibit a lower strength than those set in air, it did have an appropriate setting time and strength for clinical applications. In conclusion, P/L ratio optimization successfully improved the strength of injectable mβ-TCP cement. (徳島大学機関リポジトリ) ● Metadata: 111978 (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.2016-341 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28450674 ● Summary page in Scopus @ Elsevier: 2-s2.0-85030149005 (徳島大学機関リポジトリ: 111978, DOI: 10.4012/dmj.2016-341, PubMed: 28450674, Elsevier: Scopus)
13.	Yoko Henmi, Yoshihito Naitou, Ryo Jimbo, Yohei Jinno, Kazumitsu Sekine and Kenichi Hamada : Bone Ingrowth to Ti Fibre Knit Block with High Deformability, Journal of Oral & Maxillofacial Research, Vol.7, No.4, e2, 2016. (徳島大学機関リポジトリ) ● Metadata: 110102 (出版サイトへのリンク) ● Publication site (DOI): 10.5037/jomr.2016.7402 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28154746 ● Search Scopus @ Elsevier (PMID): 28154746 ● Search Scopus @ Elsevier (DOI): 10.5037/jomr.2016.7402 (徳島大学機関リポジトリ: 110102, DOI: 10.5037/jomr.2016.7402, PubMed: 28154746)
14.	Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of high-energy ball-milling on injectability and strength of β-tricalcium-phosphate cement, Journal of the Mechanical Behavior of Biomedical Materials, Vol.47, 77-86, 2015. (要約) Calcium phosphate cement (CPC) offers many advantages as a bone-substitution material. The objective of this study is to develop a new CPC that simultaneously exhibits fine injectability, a short setting time, and high strength. β-tricalcium phosphate (β-TCP, control) powder was ball-milled for 24h to produce a new cement powder. The modified β-TCP after 24h milling (mβ-TCP-24h) exhibited excellent injectability even 1h after mixing. The mechanical properties of the set cement (compact) were evaluated using compressive strength (CS) and diametral tensile strength (DTS) testing. The CS and DTS values of the mβ-TCP-24h compacts were 8.02MPa and 2.62MPa, respectively, at 5h after mixing, and were 49.6MPa and 7.9MPa, respectively, at 2 weeks after mixing. All the CS and DTS values of the mβ-TCP-24h compacts were significantly higher than those of the control for the same duration after mixing. These results suggest that the mechano-chemically modified β-TCP powder dissolves rapidly and accelerates hydroxyapatite precipitation, which successfully shortens the cement setting time and enhances the strength. This study supports that mβ-TCP-24h is a promising candidate for use in injectable CPCs with improved strength. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jmbbm.2015.03.005 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25855467 ● Summary page in Scopus @ Elsevier: 2-s2.0-84926341883 (DOI: 10.1016/j.jmbbm.2015.03.005, PubMed: 25855467, Elsevier: Scopus)
15.	Bae Ji-young, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of high-energy ball-milling on injectability and strength of β-tricalcium-phosphate cement, Journal of the Mechanical Behavior of Biomedical Materials, No.47, 77-86, 2015.
16.	Shinya Horiuchi, Masahiro Hiasa, Akihiro Yasue, Kazumitsu Sekine, Kenichi Hamada, Kenzo Asaoka and Eiji Tanaka : Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement., Journal of the Mechanical Behavior of Biomedical Materials, Vol.29C, 151-160, 2014. (要約) Recently, zinc-releasing bioceramics have been the focus of much attention owing to their bone-forming ability. Thus, some types of zinc-containing calcium phosphate (e.g., zinc-doped tricalcium phosphate and zinc-substituted hydroxyapatite) are examined and their osteoblastic cell responses determined. In this investigation, we studied the effects of zinc calcium phosphate (ZCP) derived from zinc phosphate incorporated into calcium phosphate cement (CPC) in terms of its setting reaction and MC3T3-E1 osteoblast-like cell responses. Compositional analysis by powder X-ray diffraction analysis revealed that HAP crystals were precipitated in the CPC containing 10 or 30wt% ZCP after successfully hardening. However, the crystal growth observed by scanning electron microscopy was delayed in the presence of additional ZCP. These findings indicate that the additional zinc inhibits crystal growth and the conversion of CPC to the HAP crystals. The proliferation of the cells and alkaline phosphatase (ALP) activity were enhanced when 10wt% ZCP was added to CPC. Taken together, ZCP added CPC at an appropriate fraction has a potent promotional effect on bone substitute biomaterials. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jmbbm.2013.09.005 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24090874 ● Summary page in Scopus @ Elsevier: 2-s2.0-84884959362 (DOI: 10.1016/j.jmbbm.2013.09.005, PubMed: 24090874, Elsevier: Scopus)
17.	Kazumitsu Sekine, Minoru Sakama and Kenichi Hamada : Evaluation of strontium introduced apatite cement as the injectable bone substitute developments., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.2013 35th, 858-861, 2013. (要約) We have developed bone cement introducing Strontium (Sr) to promote early bone regeneration. To prolong the release duration of Sr, we applied inorganic Sr filler for containing into the cement powder. The purpose of this study is to evaluate the mechanical properties, crystallinic properties, and ion release activities, especially Sr anion, of this cement. Alpha-TCP powder was mixed with Sr filler, with 0.1wt%, 0.5wt%, 1.0wt%, and 5.0wt%. These were mixed with mixing liquid and formed for each test. They were incubated and crystalized in 95% moisture for 1 week. The mechanical properties were studied by the compression, the diametral tensile strength and 4-point vending. Tested specimens were evaluated by X-ray diffraction(XRD) and scanning electron microscopic(SEM) imaging. The ion release behaviors were measured by inductively coupled plasma mass spectrometry(ICP-MS). The mechanical properties were increased in consistency of filler, but decreased in some samples because of declining the apatite matrix. And the Sr release showed interesting results as the sequential resource of Sr. By adjusting the mixing ratio or considering the application of these Sr releasable cements, this material would show good performance by its strength and longer Sr release for bone regeneration. (キーワード) Apatites / Bone Cements / Bone Substitutes / Compressive Strength / 結晶化 (crystallization) / Injections / Materials Testing / Microscopy, Electron, Scanning / Strontium / Tensile Strength / X線回折 (X-ray diffraction) (出版サイトへのリンク) ● Publication site (DOI): 10.1109/EMBC.2013.6609636 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24109823 ● Search Scopus @ Elsevier (PMID): 24109823 ● Search Scopus @ Elsevier (DOI): 10.1109/EMBC.2013.6609636 (DOI: 10.1109/EMBC.2013.6609636, PubMed: 24109823)
18.	Kazumitsu Sekine, Bae Young Ji, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : Evaluation of newly developed bone cement introducing Strontium consistencies for bone regenerative substitute, Transactions of the Japanese Society for Medical and Biological Engineering, 2012.

学術論文(紀要・その他):

1.	Yeeun Kim, Kenichi Hamada and Kazumitsu Sekine : The effect of supplementing the calcium phosphate cement containing poloxamer 407 on cellular activities, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.112, No.1, e35335, 2024. (キーワード) Calcium phosphate cement / Cell adhesion / 細胞毒性 (cytotoxicity) / Poloxamer 407 / beta-TCP (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.35335 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.35335 (DOI: 10.1002/jbm.b.35335)
2.	Yeeun Kim, Emi Takegawa, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of poloxamer additives on strength, injectability, and shape stability of beta-tricalcium phospEffects of poloxamer additives on strength, injectability, and shape stability of beta-tricalcium phosphate cement modified using ball-millinghate cement modified using ball-milling, Journal of the Mechanical Behavior of Biomedical Materials, 2022. (要約) A new CPC was developed in this study using a β-TCP powder mechano-chemically modified by ball-milling. The prototype CPC exhibits excellent fluidity for easy injection into bone defects; however, there is a risk of leakage from the defects immediately after implantation due to its high fluidity. The addition of poloxamer, an inverse thermoresponsive gelling agent, into CPC optimizes the fluidity. At lower temperatures, it forms a sol and maintains good injectability, whereas at the human body temperature, it transforms to a gel, reducing the fluidity and risk of leakage. In this study, the effects of poloxamer addition of 3, 5, and 10 mass% on the injectability, shape stability, and strength of the prototype CPC were evaluated. The calculated injectability of the prototype CPC pastes containing three different poloxamer contents was higher than that of the CPC paste without poloxamer for 15 min at 37 °C. Furthermore, the shape stability immediately after injection of the three CPC pastes with poloxamer was higher than that of the CPC paste without poloxamer. After 1 week of storage at 37 °C, the compressive strength and diametral tensile strength of the CPC compacts containing 10 mass% poloxamer were similar to those of the CPC compact without poloxamer. Additionally, the CPC compacts containing 10 mass% poloxamer exhibited clear plastic deformation after fracture. These results indicate that the addition of poloxamer to the prototype CPC could reduce the risk of leakage from bone defects and improve the fracture toughness with maintaining the injectability and strength. (徳島大学機関リポジトリ) ● Metadata: 116796 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jmbbm.2022.105182 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jmbbm.2022.105182 (徳島大学機関リポジトリ: 116796, DOI: 10.1016/j.jmbbm.2022.105182)
3.	関根一光 : コイル状形状記憶合金を応用した機能代行型人工食道デバイスの開発, 四国歯学会雑誌, Vol.22, No.2, 199-200, 2010年. (徳島大学機関リポジトリ) ● Metadata: 109799 (徳島大学機関リポジトリ: 109799)

学術レター:

1.	Kazumitsu Sekine and 三田村好矩 : Cytotoxic Evaluation of Magnetic Fluid, Proceedings of Japan-Taiwan International Conference on Magnetic Fluids 2018, 18-20, 2018.
2.	関根一光 : 金属粉末を用いた微細porous表面の作製によるオーダーメイド加工可能なbiolized血液接触表面の作製, 人工臓器, Vol.40, No.1, 42-43, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571980074961160064 (CiNii: 1571980074961160064)

総説・解説:

1.	関根一光 : 人工材料(無機), 人工臓器, Vol.49, No.3, 159-161, 2020年12月. (出版サイトへのリンク) ● Publication site (DOI): 10.11392/jsao.49.159 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390850313415617920 ● Search Scopus @ Elsevier (DOI): 10.11392/jsao.49.159 (DOI: 10.11392/jsao.49.159, CiNii: 1390850313415617920)

国際会議:

1.	Yeeun Kim, Kenichi Hamada and Kazumitsu Sekine : Effect of poloxamer 407 on cytocompatibility of calcium phosphate cement for bone regeneration, 33rd Annual Conference of the European Society for Biomaterials (ESB2023), Davos, Sep. 2023.
2.	Yeeun Kim, Kenichi Hamada and Kazumitsu Sekine : Effects of poloxamer 407 on cytocompatibility of calcium phosphate cement for bone regenereation, 33rd Annual Conference of the European Society for Biomaterials (ESB2023), Davos, Sep. 2023.
3.	Raras Ajeng Enggardipta, Minato Akizuki, Tomoko Sumitomo, Kazumitsu Sekine, Kenichi Hamada and Hiromichi Yumoto : Comparison of Chitosan with Different Molecular Weights as Possible Antibiofilm Materials Against Enterococcus faecalis Biofilms, The 22nd Scientific Congress of the Asian Pacific Endodontic Confederation (APEC) 2023, Aug. 2023.
4.	Kenichi Hamada, Yuta Matsuki, Hiroko Sato, 梶本昇, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka : DEVELOPMENT OF SMART DENTAL CEMENT ELECTRICALLY DEBONDABLE ON-DEMAND: EFFECTS OF IMMERSION IN SODIUM CHLORIDE SOLUTION, Biomaterials International 2023, Sapporo, Jul. 2023.
5.	Raras Ajeng Enggardipta, Minato Akizuki, Kazumitsu Sekine, Kenichi Hamada, Akikazu Murakami and Hiromichi Yumoto : The preliminary study of chitosan nanoparticles as antibacterial agent on Enterococcus faecalis biofilm, 19th Scientific Meeting and Refresher Course in Dentistry (Jakarta, Indonesia), Feb. 2023.
6.	Kenichi Hamada, Yuta Matsuki, Hiroko Sato, 梶本昇, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka : Effects of Immersion in NaCl Solutions on Shear Bond Strength and Electric Conductivity of a Dental Cement, The 7th International Symposium on Biomedical Engineering (ISBE2022), Nov. 2022.
7.	Kenichi Hamada, Yuta Matsuki, Hiroko Sato, 梶本昇, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka : Shear bond strength change due to current application of resin-modified glass-ionomer-cement immersed in NaCl solutions, International Dental Materials Congress 2022, Nov. 2022.
8.	Yeeun Kim, Kazumitsu Sekine and Kenichi Hamada : Effects of poloxamer additives on strength, injectability of beta-tricalcium phosphate cement, International Dental Materials Congress 2022, Nov. 2022.
9.	Kenichi Hamada, Hiroko Sato, Noboru Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka : Change of electric and mechanical properties of ionic-liquid containing ``smart'' resin-modified glass-ionomer-cement with water immersion, Thermec' 2021, Wien, Jun. 2021.
10.	Kenichi Hamada, Hiroko Sato, Noboru Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine and Eiji Tanaka : Water immersion effects on bonding strength of dental cement containing ionic-liquid, 11th World Biomaterials Congress, Glasgow, Dec. 2020.
11.	Yuta Matsuki, Hiroko Sato, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada : Electrolytic solution immersion effects on novel glass ionomer cement -Change of electric conductivity and shear bonding reduction after current application-, 9th IOC, Yokohama, Oct. 2020.
12.	Hiroko Sato, Yuta Matsuki, Noboru Kajimoto, Emi Takegawa, Shinya Horiuchi, Kazumitsu Sekine, Eiji Tanaka and Kenichi Hamada : Water immersion effects on novel glass ionomer cement containing ionic liquid Changes of electric effects on novel glass ionomer cement containing ionic liquid-., 9th IOC, Yokohama, Oct. 2020.
13.	Yeeun Kim, Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of zirconia additives on beta-tricalcium-phosphate cement strength of high injectability, 8th International Conference on Mechanics of Biomaterials and Tissues, Waikoloa, Dec. 2019.
14.	Mitamura Yoshinori, Kazumitsu Sekine and Okamoto Eiji : Magnetic fluid seals working in liquid environments: factors limiting their life and solution methods, International Conference on Magnetic Fluids 2019, 294-295, Paris, Jul. 2019.
15.	Kazumitsu Sekine and 三田村好矩 : Cytotoxic Evaluation of Magnetic Fluid, Japan-Taiwan International Conference on Magnetic Fluids 2018, Kanagawa, Nov. 2018.
16.	Kazumitsu Sekine, Yoshihito Naitou, Tetsuo Ichikawa, Otto Baba and Kenichi Hamada : Development of structural and chemical enforcement of neointimal growth as the blood contacting surface for the vascular prosthesis, 45th European Society for Artificial Organs 2018 Congress, Madrid, Sep. 2018.
17.	Yeeun Kim, Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Three types of zirconia particle addition to calcium phosphates cement for strengthening, 29th European Conference on Biomaterials (ESB2018), Maastricht, Sep. 2018.
18.	Kazumitsu Sekine and Mitamura Yoshinori : Cytotoxicity evaluation of magnetic fluid based on cell proliferations, Taiwan-Japan International Conference on Magnetic Fluids 2017, Tainan, Dec. 2017.
19.	Yeeun Kim, Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Setting Properties and Strengths of β-TCP Cements Set in Vivo and in SBF, 28th European Conference on Biomaterials (ESB2017), Athens, Sep. 2017.
20.	Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Zirconia Particle Addition to Calcium-Phosphates-Cement for Mechanical Property Enhancement, 28th European Conference on Biomaterials (ESB2017), Athens, Sep. 2017.
21.	三田村好矩 and Kazumitsu Sekine : Cytotoxicity of Magnetic Fluid, Japan-Taiwan International Conference on Magnetic Fluids 2016, Sapporo, Dec. 2016.
22.	Prananingrum Widyasri, Yoshihito Naitou, Kazumitsu Sekine, Kenichi Hamada and Tetsuo Ichikawa : Application of porous titanium in tailored post-core systems using a moldless process: evaluation of the physical and mechanical properties with different particle sizes, International Dental Materials Congress 2016, Bali, Nov. 2016.
23.	Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of zirconia particle addition on mechanical properties of calcium phosphate cement, International Dental Materials Congress 2016, Bali, Nov. 2016.
24.	Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Zirconia particle addition improves mechanical properties of calcium phosphate ceramic, 94th General Session and Exhibition of the International Association for Dental Research, Seoul, Jun. 2016.
25.	Prananingrum Widyasri, Yoritoki Tomotake, Yoshihito Naitou, Kazumitsu Sekine, Kenichi Hamada and Tetsuo Ichikawa : Sintering Time and Its Influence on Moldless-Processed Porous Titanium's Properties, 94th General Session and Exhibition of the International Association for Dental Research, Seoul, Jun. 2016.
26.	Yumika Ida, Jiyon Be, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Powder/liquid ratio effects on mechanical properties of modified β-TCP cement, 94th General Session and Exhibition of the International Association for Dental Research, Seoul, Jun. 2016.
27.	Kajimoto Noboru, Emi Takegawa, Kazumitsu Sekine and Kenichi Hamada : Development of an electrically-debondable smart dental cement, Thermec' 2016, Graz, Jun. 2016.
28.	Henmi Yoko, Yoshihito Naitou, Jinbo Ryo, Jinno Yohei, Kazumitsu Sekine and Kenichi Hamada : Development of three-dimensional porous titanium web for bone defect filling, Thermec' 2016, Graz, Jun. 2016.
29.	Yumika Ida, Bae Ji-young, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effect of powder/liquid ratio on the strengh of mechano-chemically modified β-tricalcium phosphate cement, 27th European Conference on biomaterials(ESB2015), Sep. 2015.
30.	Yumika Ida, Jiyon Be, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Effects of powder/liquid ratio on the strength of β-tricalcium phosphate cement modified mechano-chemically, 27th European Conference on Biomaterials (ESB2015), Cracow, Aug. 2015.
31.	Kazumitsu Sekine, Jiyon Be, Yoshihito Naitou, Tetsuo Ichikawa and Kenichi Hamada : Development of micro-porous Titanium scaffold for promoting the early neointimal growth, Materials Today Asia 2014, Hong Kong, Dec. 2014.
32.	IDA Yumika, Jiyon Be, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Strength injectability of β-TCP based Calcium Phosphate Cement using mechano-chemical process, Materials Today Asia 2014, Hong Kong, Dec. 2014.
33.	Yumika Ida, Bae Ji-Young, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Strength and injectability of β-TCP based Calcium phosphate Cement using mechano-chemical process, Materials Today Asia, Dec. 2014.
34.	Bae Ji-Young, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : The effects of high energy ball-milling on injectability and strength of β-tricalcium phosphate cement, 15th International Symposium in conjunction with 9th Nano Biomedical Society Meeting, Nov. 2014.
35.	Jiyon Be, Ida Yumika, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Properties of β-TCP based Calcium Phosphate Cement using mechano-chemical process, 26th European Conference on Biomaterials (ESB2014), Liverpool, Sep. 2014.
36.	Bae Ji-Young, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : Properties of β-TCP based Calcium Phosphate Cement using mechano-chemical process, 26th European Conference on Biomaterials(ESB2014), Sep. 2014.
37.	Kazumitsu Sekine, Jiyon Be, Yoshihito Naitou, Tetsuo Ichikawa and Kenichi Hamada : Fundamental studies of micro-porous titanium scaffold for obtaining the neointimal formation., Joint congress of 51st Annual Meeting of the Japanese Society for Artificial Organs and 5th Congress of the International Federation for Artificial Organs, Yokohama, Sep. 2013.
38.	Jiyon Be, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : A quick setting calcium phosphate cement: Effects of planetary ball milling, 15th International College of Prosthodontists Biennial Meeting, Turin, Sep. 2013.
39.	Bae Ji-Young, Yumika Ida, Kazumitsu Sekine, Fumiaki Kawano and Kenichi Hamada : A quick setting calcium phosphate cement:Effects of planetary ball milling, 15th Biennial Meeting of international College of Prosthodontists, Sep. 2013.
40.	Kazumitsu Sekine, Yoshihito Naitou and Kenichi Hamada : Fundamental studies and development of micro-porous titanium blood contacting surface obtaining the neointimal formation., 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Osaka, Jul. 2013.
41.	Kazumitsu Sekine, Minoru Sakama and Kenichi Hamada : Evaluation of strontium introduced apatite cement as the injectable bone substitute developments, 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Osaka, Jul. 2013. (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24109823 ● Summary page in Scopus @ Elsevier: 2-s2.0-84886529651 (PubMed: 24109823, Elsevier: Scopus)
42.	Kazumitsu Sekine, Kenichi Hamada, Jiyon Be, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : Evaluation of Strontium Introduced Apatite Cement for Injectable Bone Substitute Developments, ASEAN plus and Tokushima Joint International Conference, Yogyakarta, Dec. 2012.
43.	Kazumitsu Sekine, Yambe Tomoyuki, Shiraishi Yasuyuki, Matsuki Hidetoshi, Sato Fumihiro, Maeda Tsuyoshi, Honma Dai and Kenzo Asaoka : Drinking Mechanism for the Development of the Artificial Esophagus, 38th Congress of the European Society for Artificial Organs and 4th Biennial Congress of the International Federation on Artificial Organs, Porto, Oct. 2011.
44.	Kazumitsu Sekine, Kenichi Hamada, Emi Takegawa, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : In vitro and consistency evaluation of strontium apatite bone cement., 3rd International Symposium on Surface and Interface of Biomaterials, Sapporo, Jul. 2011.
45.	Kazumitsu Sekine, Kenichi Hamada, Emi Takegawa, Fumiaki Kawano and Kenzo Asaoka : In vitro and in vivo evaluation of strontium-substituted apatite bone cement, International Dental Materials Congress 2011, Seoul, May 2011.
46.	Kazumitsu Sekine, Kenichi Hamada, Emi Takegawa, Fumiaki Kawano, Kikuji Yamashita and Kenzo Asaoka : Biocompatibility Evaluation of Strontium-substituted Apatite Bone Cement, 88th General Session and Exhibition of the International Association for Dental Research, Barcelona, Jul. 2010.
47.	Kazumitsu Sekine, Kenichi Hamada, Emi Takegawa, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : Biocompatibility evaluation of Strontium-substituted apatite cement, 3rd Hiroshima Conference on Education and Science in Dentistry, Vol.3, No.1, 83, Hiroshima, Nov. 2009.

国内講演発表:

1.	和田涼平, 武川恵美, 堀内信也, 関根一光, 田中栄二, 浜田賢一 : レジン添加型グラスアイオノマーセメントの接着強度に印加電圧の変動が与える影響, 第82回日本歯科理工学会学術講演会, 2024年4月. (キーワード) スマートセメント / レジンセメント / 接着 / 剥離
2.	関根一光, 可児耕一, 福井仁美 : 臨床系チュートリアル授業のデジタル化推進における課題, 第19回大学教育カンファレンスin徳島, 2023年12月.
3.	花輪茂己, 関根一光, キムイエウン, 浜田賢一, 田中栄二 : ボールミリング法で改質したリン酸カルシウムセメントへのポロキサマー・コラーゲン・クエン酸ゲルの添加効果, 第61回日本人工臓器学会大会, 2023年11月.
4.	関根一光, 武川恵美, キムイエウン, 花輪茂己, 浜田賢一 : 抗菌性と細胞足場効果の向上を期待したチタン表面修飾の研究, 令和5年度日本歯科理工学会近畿·中四国地方会セミナー, 2023年10月.
5.	関根一光, キムイエウン, 花輪茂己, 浜田賢一 : 3Dプリンタモデリングを利用した骨補填術へのPVAによる骨膜代替法に関する基礎研究, 第60回日本人工臓器学会大会, 2022年11月.
6.	花輪茂己, 関根一光, キムイエウン, 浜田賢一, 田中栄二 : in vivo下および疑似in vivo環境下で結晶化させた改質型リン酸カルシウムセメントの生体内硬化挙動に関する評価と解析, 第60回日本人工臓器学会大会, Vol.51, No.2, S-181, 2022年11月.
7.	松木佑太, 佐藤博子, 梶本昇, 堀内信也, 関根一光, 田中栄二 : 通電によるレジン添加型グラスアイオノマーセメントのせん断強度低下に塩化ナトリウム溶液浸漬が与える影響, 第81回日本矯正歯科学会学術大会, 2022年10月.
8.	浜田賢一, キムイエウン, 武川恵美, 関根一光, 河野文昭 : 高注入性と高流出抵抗が両立するリン酸カルシウムセメントの開発, 日本セラミックス協会第35回秋季シンポジウム, 2022年9月.
9.	浜田賢一, 松木祐太, 佐藤博子, 梶本昇, 武川恵美, 堀内信也, 関根一光 : 食塩水に浸漬したレジン添加型グラスアイオノマーセメントの電気伝導性と通電後の接着強度低下量の変化, 第79回日本歯科理工学会大会, 2022年5月.
10.	梶本昇, 佐藤平, 丸田道人, 武川恵美, 関根一光, 浜田賢一, 都留寛治 : 通電剥離型歯科用セメントの開発その6:イオン液体が細胞毒性に及ぼす影響, 第77回日本歯科理工学会大会, 2021年4月.
11.	関根一光, 武川恵美, 浜田賢一 : 組織封鎖性を担うチタン足場材の検討, 第76回日本歯科理工学会大会, 2021年2月.
12.	関根一光, 馬場麻人, 浜田賢一 : 表面修飾を施した多孔質チタンインプラントの組織封鎖性評価, 第58回日本人工臓器学会大会, 2020年11月.
13.	岡本英治, 矢野哲也, 関根一光, 三田村好矩 : カテーテル型軸流血液ポンプに用いる磁性流体軸シールの開発, 第59回日本生体医工学会大会, 2020年5月.
14.	関根一光, 馬場麻人, 浜田賢一 : 骨代替インプラントを目的とした封鎖性の高いチタンスキャフォールドの開発, 第59回日本生体医工学会大会, 2020年5月.
15.	キムイエウン, 裵志英, 伊田百美香, 関根一光, 河野文昭, 浜田賢一 : 注入性に優れるβ-TCP基骨セメントの強度へのジルコニア微粉末添加の効果, 徳島県歯科医学大会, 28, 2020年2月.
16.	佐藤博子, 松木佑太, 梶本昇, 武川恵美, 堀内信也, 関根一光, 田中栄二, 浜田賢一 : 通電するとグラスアイオノマーセメントの接着強度は低下する, 徳島県歯科医学大会, 28, 2020年2月.
17.	関根一光, 馬場麻人, 浜田賢一 : 細胞賦活化処理による多孔質性状チタン足場材の生体内癒合性の向上を狙う, 第58回日本生体医工学会大会, 2019年6月.
18.	関根一光, 馬場麻人, 浜田賢一 : 細胞賦活性を施した多孔質チタン足場材に関する生体内癒合性評価, 第56回日本人工臓器学会大会, 2018年11月.
19.	梶本昇, 荒平高章, Maruta Michihito, 武川恵美, 関根一光, 浜田賢一, 都留寛治 : スマートに剥離可能な新規歯科用セメントの開発:剥離メカニズムの考察, 第37回日本接着歯学会, 2018年10月.
20.	キムイエウン, 裵志英, 伊田百美香, 関根一光, 河野文昭, 浜田賢一 : 高強度β-TCP セメントの開発: ジルコニアファイバー添加の效果, 第72回日本歯科理工学会学術講演会, 2018年10月.
21.	梶本昇, 荒平高章, 丸田道人, 武川恵美, 関根一光, 浜田賢一, 都留寛治 : 通電剥離型歯科用セメントの開発その5:通電がセメントに与える影響, 第72回日本歯科理工学会学術講演会, 2018年10月.
22.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCP セメントのin vivo 評価, 第72回日本歯科理工学会学術講演会, 2018年10月.
23.	関根一光, 馬場麻人, 浜田賢一 : 硬組織代替材料への応用を目的としたチタン表面への細胞賦活効果の検討, 第57回日本生体医工学会大会, 2018年6月.
24.	関根一光, 山下菊治, 浜田賢一 : 血管内皮新生を目的としたチタン粒子焼結による多孔性チタン表面の軟組織癒合性評価, 第39回日本バイオマテリアル学会大会, 2017年11月.
25.	三田村好矩, 関根一光 : 磁性流体の細胞毒性, 平成29年度磁性流体連合講演会, 2017年11月.
26.	関根一光, 山下菊治, 浜田賢一 : 血管内皮新生の促進効果を狙った多孔性チタン材への表面加工の検討, 第55回日本人工臓器学会大会, 2017年9月.
27.	関根一光, 伊田百美香, 裵志英, 浜田賢一 : メカノケミカル手法による早期硬化性CPCセメントの生体内環境での硬化性の評価, 第55回日本人工臓器学会大会, 2017年9月.
28.	吉田幸司, 梶本昇, 武川恵美, 関根一光, 浜田賢一 : 通電剥離型歯科用セメント(EDDC)の開発 ∼アミノ酸由来イオン液体を用いた検証∼, 四国歯学会第51回例会, 2017年6月.
29.	裵志英, 伊田百美香, 関根一光, 浜田賢一 : ボールミリング法で改質したβ-TCPセメントのin SBFとin vivoでの硬化後の性質, 第56回日本生体医工学会大会, 2017年5月.
30.	関根一光, 裵志英, 浜田賢一 : 多孔質化と表面処理による複合的なチタン製血液接触表面材料としての試み, 第56回日本生体医工学会大会, 2017年5月.
31.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 通電剥離型歯科用セメントの開発その 4:破壊様式の観察, 第69回日本歯科理工学会学術講演会, 2017年4月.
32.	邉見蓉子, 関根一光, 神野洋平, 神保良, 内藤禎人, 友竹偉則, 浜田賢一 : 多孔性チタン編物の変形特性の異方性, 日本金属学会2017年春季大会, 2017年3月.
33.	邉見蓉子, 内藤禎人, 神保良, 神野洋平, 関根一光, 浜田賢一 : 薬剤含有チタン繊維編物の骨形成能, 第5回日本バイオマテリアル学会中四国ブロックシンポジウム, 2017年1月.
34.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 任意に除去可能な歯科用セメントの開発, 第5回日本バイオマテリアル学会中四国ブロックシンポジウム, 2017年1月.
35.	関根一光, 山下菊治, 浜田賢一 : 細胞接着性の向上を狙ったチタン材への水酸化処理法の癒合性足場材料としての検討, 第54回日本人工臓器学会大会, 2016年11月.
36.	邉見蓉子, 内藤禎人, 神保良, 神野洋平, 関根一光, 浜田賢一 : 3 次元多孔性チタン織物の変形能と in vivo における骨伝導能, 日本バイオマテリアルシンポジウム2016, 2016年11月.
37.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : ボールミリング法で改質したβ-TCP セメントのin vivoでの圧縮強度の評価, 日本バイオマテリアルシンポジウム2016, 2016年11月.
38.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 通電により剥離可能な歯科用セメントの開発, 第23回日本歯科医学会総会, 2016年10月.
39.	邉見蓉子, 内藤禎人, 神保良, 関根一光, 浜田賢一 : 家兎の骨欠損部に充填した 3 次元多孔性チタン織物の骨再生能, 第43回日本臨床バイオメカニクス学会, 2016年10月.
40.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : 微粉化するとβ-TCP セメント硬化体の機械的特性は変化する, 第43回日本臨床バイオメカニクス学会, 2016年10月.
41.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : 微分化するとβ-TCP セメント硬化体の機械的特性は変化する, 第43回日本臨床バイオメカニクス学会, 2016年10月.
42.	邉見蓉子, 関根一光, 神野洋平, 神保良, 内藤禎人, 友竹偉則, 浜田賢一 : 高い変形能を示す多孔性チタン織物の骨伝導能, 日本金属学会2016年秋季大会, 2016年9月.
43.	浜田賢一, 梶本昇, 武川恵美, 関根一光 : スマート・デンタル・マテリアル -スマート材料・構造の歯科応用-, 日本セラミックス協会第29回秋季シンポジウム, 2016年9月.
44.	関根一光 : イオン液体混合歯科用セメント(スマートセメント)の細胞毒性評価, 日本歯科理工学会近畿中四国地方会夏期セミナー, 2016年8月.
45.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 通電剥離型歯科用セメントの開発:通電剥離に関連する因子の考察, 日本歯科理工学会近畿中四国地方会夏期セミナー, 2016年8月.
46.	関根一光, 内藤禎人, 市川哲雄, 山下菊治, 浜田賢一 : Surface modification of titanium scaffold for applying cell growth promotion, 第55回日本生体医工学会大会, 2016年4月.
47.	邉見蓉子, 内藤禎人, 関根一光, 浜田賢一 : 骨欠損部に充填する三次元多孔性チタン織物の開発, 第67回日本歯科理工学会学術講演会, 2016年4月.
48.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 通電剥離型歯科用セメントの開発その3:被着体による剥離特性の差異, 第67回日本歯科理工学会学術講演会, 2016年4月.
49.	関根一光, 内藤禎人, 浜田賢一 : 細胞賦活効果向上を目的としたチタン材表面処理法, 第67回日本歯科理工学会学術講演会, 2016年4月.
50.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCP セメントの粉液比の増加による強度と注入性, 第67回日本歯科理工学会学術講演会, 2016年4月.
51.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : ボールミリング法で改質したβ-TCPセメントの粉液比の増加による強度と注入性, 第4回日本バイオマテリアル学会中四国シンポジウム, 2016年2月.
52.	邉見蓉子, 内藤禎人, 神保良, 神野洋平, 関根一光, 浜田賢一 : 三次元多孔性チタン織物の機械的特性と骨伝導能, 第4回日本バイオマテリアル学会中四国シンポジウム, 2016年2月.
53.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 接着力を制御できる歯科用セメントの開発, 第4回日本バイオマテリアル学会中四国シンポジウム, 2016年2月.
54.	関根一光, 裵志英, 内藤禎人, 市川哲雄, 浜田賢一 : 早期内膜新生を狙ったチタン多孔質スキャフォールドの作成と評価, 第37回日本バイオマテリアル学会大会, 2015年11月.
55.	邉見蓉子, 内藤禎人, 神保良, 関根一光, 浜田賢一 : 骨欠損部に充填する三次元多孔性チタン織物の開発, 第37回日本バイオマテリアル学会大会, 2015年11月.
56.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : ボールミリング法で改質したβ-TCPセメントの機械的性質に及ぼす混水比の影響, 第37回日本バイオマテリアル学会大会, 2015年11月.
57.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : ボールミリング法で改質したβ-TCPセメントの機械的性質に及ぼす混水比の影響, 第37回日本バイオマテリアル学会, 2015年11月.
58.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCP セメントの注入性と気孔率に粉液比が及ぼす影響, 第66回日本歯科理工学会学術講演会, 2015年10月.
59.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 通電剥離型歯科用セメントの開発その2: 通電条件の影響, 第66回日本歯科理工学会学術講演会, 2015年10月.
60.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCPセメントの注入性と気孔率に粉液比が及ぼす影響, 第66回日本歯科理工学会学術講演会, 2015年10月.
61.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 強固に接着し容易に除去できる歯科用スマートセメントの開発, 第31回「歯科医学を中心とした総合的な研究を推進する集い」, 2015年9月.
62.	梶本昇, 武川恵美, 関根一光, 浜田賢一 : 工業用解体性接着技術の歯科分野への応用, 日本歯科理工学会近畿中四国地方会夏期セミナー, 2015年8月.
63.	梶本昇, 関根一光, 浜田賢一 : 通電剥離型歯科用セメントの開発その1:剥離特性の評価, 第65回日本歯科理工学会学術講演会, 2015年4月.
64.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCP セメントの強度に粉液比が及ぼす影響, 第65回日本歯科理工学会学術講演会, 2015年4月.
65.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCPセメントの強度に粉液比が及ぼす影響, 第65回日本歯科理工学会学術講演会, 2015年4月.
66.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : 改質β-TCPセメントの粉液比と強度, 第3回日本バイオマテリアル学会中四国シンポジウム, 2015年1月.
67.	梶本昇, 関根一光, 浜田賢一 : 歯科用スマートセメントのコンセプトと実証, 第3回日本バイオマテリアル学会中四国シンポジウム, 2015年1月.
68.	関根一光, 裵志英, 内藤禎人, 市川哲雄, 浜田賢一 : チタン微粒子焼結と表面改質による血管内皮誘導を目的としたチタン多孔質体の開発, 第52回日本人工臓器学会大会, 2014年10月.
69.	裵志英, 伊田百美香, 関根一光, 河野文昭, 浜田賢一 : The effects of high energy ball-milling on injectability and strength of β-tricalcium phosphate cement., 第52回日本人工臓器学会大会, 2014年10月.
70.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCP セメントの特性, 第64回日本歯科理工学会学術講演会, 2014年10月.
71.	関根一光, 河野文昭, 浜田賢一 : ストロンチウム(Sr)を導入したリン酸カルシウムセメントにおけるイオン徐放性の評価, 第64回日本歯科理工学会学術講演会, 2014年10月.
72.	伊田百美香, 裵志英, 関根一光, 河野文昭, 浜田賢一 : メカノケミカル手法で改質したβ-TCPセメントの特性, 第64回日本歯科理工学会学術講演会, 2014年10月.
73.	関根一光, Bae Ji-Young, 内藤禎人, 市川哲雄, 浜田賢一 : チタン微粒子焼結と表面改質による血管内皮誘導を目的としたチタン多孔質体の開発, 人工臓器, Vol.43, No.2, S-221, 2014年9月. (キーワード) マイクロスフェア
74.	裵志英, 伊田百美香, 関根一光, 河野文昭, 浜田賢一 : Develop of high strength calcium phosphate cement: Effects of planetary ball milling, 第53回日本生体医工学会大会, 2014年6月.
75.	関根一光, 内藤禎人, 市川哲雄, 裵志英, 浜田賢一 : Development and evaluation of micro-porous titanium scaffold for promoting neointimal growth as the blood contacting surface, 第53回日本生体医工学会大会, 2014年6月.
76.	関根一光 : 徳島大学歯学部でのバイオマテリアル開発研究, 第2回日本バイオマテリアル学会中四国シンポジウム, 2014年2月.
77.	裵志英, 伊田百美香, 関根一光, 河野文昭, 浜田賢一 : アモルファス状リン酸三カルシウム基の高速硬化型高強度骨セメントの開発, 日本歯科技工学会中国・四国支部第8回学術大会, 2013年11月.
78.	裵志英, 伊田百美香, 関根一光, 河野文昭, 浜田賢一 : アモルファス状リン酸三カルシウム基の高速硬化型高強度骨セメントの開発, 日本歯科理工学会近畿中四国地方会夏期セミナー, 2013年9月.
79.	関根一光, 山下菊治, 淺岡憲三 : Srイオン徐放体を含有したリン酸カルシウム系セメントの基礎的性質, 第50回日本人工臓器学会大会, 2012年11月.
80.	関根一光 : 金属粉末を用いた微細ポーラス表面の作成によるオーダーメイド加工可能なBiolized血液接触表面の作成, 第50回日本人工臓器学会大会, 2012年11月.
81.	Kazumitsu Sekine, Bae Young Ji, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : Newly developed bone cement introducing Strontium consistencies for bone regenerative substitute, 第51回日本生体医工学会大会, May 2012.
82.	Kazumitsu Sekine, Yambe Tomoyuki, Shiraishi Yasuyuki, Sato Fumihiro, Matsuki Hidetoshi, Maeda Tsuyoshi and Kenzo Asaoka : Structural improvement and evaluation of peristaltic actuation artificial esophagus using shape memory alloy fiber., 第50回日本生体医工学会大会, Apr. 2011.
83.	Kazumitsu Sekine, Kenichi Hamada, Emi Takegawa, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : Bone conductivity and regeneration evaluation of Strontium-substituted apatite bone cement., 第50回日本生体医工学会大会, Apr. 2011.
84.	関根一光, 浜田賢一, 武川恵美, 河野文昭, 山下菊治, 淺岡憲三 : ストロンチウム添加型アパタイトセメントの骨置換能評価, 第48回日本人工臓器学会大会, Vol.39, No.2, 131, 2010年11月.
85.	関根一光, 白石泰之, 山家智之, 松木英敏, 佐藤文博, 前田剛, 淺岡憲三 : 形状記憶合金ファイバーを人工筋肉とした消化管蠕動運動補助アクチュエータの開発, 第48回日本人工臓器学会大会, Vol.39, No.2, 56, 2010年11月.
86.	関根一光, 浜田賢一, 武川恵美, 山下菊治, 河野文昭, 淺岡憲三 : ストロンチウム(Sr)含有型アパタイトセメントのin vitro及びin vivo評価, 第56回日本歯科理工学会学術講演会, Vol.29, No.5, 385, 2010年10月.
87.	Kazumitsu Sekine, Uyama Emi, Kikuji Yamashita, Fumiaki Kawano and Kenzo Asaoka : In vitro and in vivo evaluation of Strontium-substituted apatite bone cement., The 49th Annual Conference of Japanese Society for Medical and Biological Engineering, Vol.48, No.S1, 319, Jun. 2010.
88.	Kazumitsu Sekine, Shiraishi Yasuyuki, Yambe Tomoyuki and Kenzo Asaoka : Structure studies for improving the efficiency of an artificial peristaltic esophagus using a shape memory alloy fiber., The 49th Annual Conference of Japanese Society for Medical and Biological Engineering, Vol.48, No.S1, 322, Jun. 2010.
89.	関根一光, 浜田賢一, 山下菊治, 河野文昭, 淺岡憲三 : 早期骨置換能を目指したストロンチウム含有アパタイトセメントの生体内反応評価と骨置換能評価, 第47回日本人工臓器学会大会, Vol.38, No.2, 123, 2009年11月.
90.	関根一光, 藤原江美, 浜田賢一, 山下菊治, 河野文昭, 淺岡憲三 : 生体吸収性ストロンチウム含有アパタイトセメントの試作, 第48回日本生体医工学会大会, Vol.47, No.S1, 254, 2009年4月.
91.	関根一光, 山家智之, 白石泰之, 西條芳文, 佐藤文博, 松木英敏, 前田剛, 中澤文雄, 淺岡憲三 : コイル状形状記憶合金を応用した消化管蠕動運動アクチュエータの耐久性に関する検討, 第48回日本生体医工学会大会, Vol.47, No.S1, 188, 2009年4月.
92.	白石泰之, 山家智之, 関根一光, 本間大 : 形状記憶合金アクチュエータ, 第48回日本生体医工学会大会, Vol.47, No.S1, 95, 2009年4月.
93.	関根一光, 浜田賢一, 山下菊治, 河野文昭, 淺岡憲三 : ストロンチウム含有アパタイトセメントの生体反応性評価, 第53回日本歯科理工学会学術講演会, Vol.28, No.2, 108, 2009年4月.
94.	関根一光, 山家智之, 白石泰之, 西條芳文, 前田剛, 中澤文雄, 淺岡憲三 : 形状記憶合金を駆動力とした人工食道の開発研究 ∼"咀嚼"の先にある嚥下機能の補助デバイスとして∼, 第22回歯科チタン学会, 2009年2月.
95.	関根一光, 山家智之, 白石泰之, 西條芳文, 淺岡憲三 : 形状記憶合金ファイバーを用いた消化管蠕動運動補助アクチュエータの耐久性評価, 第46回日本人工臓器学会大会, 2008年11月.
96.	藤原江美, 関根一光, 浜田賢一, 山下菊治, 河野文昭, 淺岡憲三 : ストロンチウム含有アパタイトセメント存在下での骨芽細胞様細胞の培養, 日本バイオマテリアル学会シンポジウム2008, 2008年11月.
97.	藤原江美, 関根一光, 浜田賢一, 河野文昭, 淺岡憲三 : 高溶解型ストロンチウム含有アパタイトセメントの細胞毒性評価, 第52回日本歯科理工学会学術講演会, 2008年9月.
98.	藤原江美, 関根一光, 浜田賢一, 山下菊治, 河野文昭, 淺岡憲三 : ストロンチウム含有アパタイトセメントの特性, 第17回硬組織再生生物学会学術大会, 52, 2008年8月.
99.	白石泰之, 山家智之, 関根一光, 西條芳文, 金野敏, 仁田新一, 和田由美子, 坂田亮, 梅津光生, 小川大祐, 佐藤文博, 角張泰之, 田中明, 吉澤誠, 本間大 : 人工心筋収縮構造制御による補助効率最適化に関する基礎検討, 第46回日本生体医工学会, 2007年4月.
100.	角張泰之, 佐藤文博, 松木英敏, 関根一光, 白石泰之, 山家智之, 佐藤忠邦 : 蠕動運動機能をもつ人工食道のための胃部留置型経皮的電力伝送装置の開発, 第46回日本生体医工学会, 2007年4月.
101.	劉紅箭, 羅雲, 西條芳文, 白石泰之, 関根一光, 山家智之 : 人工肛門括約筋の体内移植における血液生化学による検討, 第46回日本生体医工学会, 2007年4月.
102.	関根一光, 山家智之, 西條芳文, 白石泰之, 松木英敏, 佐藤文博, 角張泰之, 前田剛, 中澤文雄 : 形状記憶合金を応用した消化管蠕動運動補助装置, 第46回日本生体医工学会, 2007年4月.
103.	馬場敦, 白石泰之, 関根一光, 西條芳文, 山家智之, 豊岡照彦, 井街宏 : 心室のrapid pacingによる心不全モデルの作成, 第46回日本生体医工学会, 2007年4月.
104.	末永健, 中村孝夫, 白石泰之, 山家智之, 西條芳文, 関根一光, 宮崎隆子, 山岸正明, 岡本吉弘, 田中隆, 梅津光生 : 機械式小児循環シミュレーションに基づく肺動脈弁設計開発の試み, 第46回日本生体医工学会, 2007年4月.
105.	笠原孝一郎, 田中明, 吉澤誠, 阿部健一, 小川大祐, 白石泰之, 関根一光, 山家智之, 仁田新一 : 補助人工心臓制御法と左心室仕事量の循環系シミュレータを用いた検討, 第46回日本生体医工学会, 2007年4月.

その他・研究会:

1.	関根一光, 山下菊治, 河野文昭, 淺岡憲三 : ストロンチウム徐放性リン酸カルシウムセメントに関する検討, 第24回代用臓器・再生医学研究会シンポジウム, 2012年1月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

抗菌性と血管内膜誘導性を備えた多孔質性チタンスキャフォールドの開発 (研究課題/領域番号: 21K12666 )
スマートセメントのセメント固定式インプラントへの応用 (研究課題/領域番号: 20K10036 )
チタン多孔体とチタンゲル化処理による血管内皮誘導を促進する血管用デバイス (研究課題/領域番号: 16K01359 )
チタン性マイクロポーラスとチタニアゲル化表面改質による複合型scaffold (研究課題/領域番号: 25750162 )
血管内皮誘導を狙った金属性マイクロポーラス表面修飾法の開発 (研究課題/領域番号: 23700538 )
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准教授 : 関根一光

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准教授 : 関根 一光

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

准教授 : 関根一光