Tokushima University / Educator and Researcher Directory --- Takamaru, Natsumi

Personal Web Page

https://researchmap.jp/takamaru-dent (researchmap)

Field of Study

○	Dentistry

Subject of Study

○

Book / Paper

Academic Paper (Judged Full Paper):

1.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, Keiko Kudoh, Ishikawa Kunio and Youji Miyamoto : Application and evaluation of carbonate apatite granules for mandibular bone defect reconstruction after jawbone cyst enucleation-a retrospective case series, Oral and Maxillofacial Surgery, Vol.29, No.1, 14, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10006-024-01306-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39572439 ● Search Scopus @ Elsevier (PMID): 39572439 ● Search Scopus @ Elsevier (DOI): 10.1007/s10006-024-01306-2 (DOI: 10.1007/s10006-024-01306-2, PubMed: 39572439)
2.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Ishikawa Kunio and Youji Miyamoto : Fabrication of a carbonate apatite granules sponge as a new bone substitute and its histological evaluation at rat calvarial bone defects, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ajoms.2024.05.004 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2024.05.004 (DOI: 10.1016/j.ajoms.2024.05.004)
3.	TANAKA Mariko, Shinya Horiuchi, Masahiro Hiasa, Keiichiro Watanabe, Akihiko Iwasa, Natsumi Takamaru, Hirokazu Nagai, Youji Miyamoto and Eiji Tanaka : 術後に顎関節に疼痛を訴えた顎偏位を伴う骨格性上顎前突症例, The Journal of Chu-Shikoku Orthodontic Society, Vol.35, No.1, 77-86, 2023.
4.	Akira Takahashi, Kumiko Kamada, Naoyuki Fukuda, Keiko Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, Clinical Implant Dentistry and Related Research, Vol.25, No.3, 532-539, 2023. (Summary) This in vivo study aimed to clarify the position of the sublingual artery (SLA) relative to the mandibular bone and to infer the potential risk for injury during dental implant surgery. Contrast-enhanced computed tomography images of the mouth of 50 edentulous patients (100 sides) treated at Tokushima University Hospital were reviewed. Curved planar reconstructed images perpendicular to the alveolar ridge were processed and classified into molar, premolar, canine, and incisor regions. The SLA and its branches were identified, and the distance from the mandible to the SLA was measured. The SLA was located close to the mandible (<2 mm) in the molar, premolar, canine, and incisor segments in 12.0% (95% confidence interval 5.6%-18.4%), 20.6% (12.6%-28.7%), 30.5% (21.3%-39.8%), and 41.8% (28.8%-54.9%) cases, respectively. The SLA was located within ±3 mm craniocaudally to the upper wall of the mandibular canal in the molar and premolar regions in 50% of cases and within ±5 mm craniocaudally to the mylohyoid ridge in the canine and incisor regions in the other cases, with no sex or age-related differences. The vertical distance from the alveolar ridge to the SLA was influenced by sex and age owing to alveolar resorption, indicating that the alveolar ridge is not a reliable reference for predicting SLA position. As the risk of SLA injury always exist during dental implant placement and there is no way to confirm the SLA pathways in a patient, clinicians must avoid injuring the sublingual soft tissue. (Keyword) Dental Implants / Mandible / Alveolar Process / Tomography, X-Ray Computed / Cone-Beam Computed Tomography / Arteries (Link to Publication Site) ● Publication site (DOI): 10.1111/cid.13197 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36896477 ● Search Scopus @ Elsevier (PMID): 36896477 ● Search Scopus @ Elsevier (DOI): 10.1111/cid.13197 (DOI: 10.1111/cid.13197, PubMed: 36896477)
5.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, 浦田豊彰, 永井和弘 and Youji Miyamoto : A case of fishbone in the tongue that migrated toward the hyoid bone, Japanese Journal of Oral & Maxillofacial Surgery, Vol.68, No.2, 58-62, 2023. (Keyword) 魚骨 / 異物 / 舌 / 舌骨 / 術中超音波検査 / fishbone / foreign body / tongue / hyoid bone / intraoperative ultrasonography (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.69.58 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390295823371025920 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.69.58 (DOI: 10.5794/jjoms.69.58, CiNii: 1390295823371025920)
6.	Keiko Kudoh, Go Ohe, Natsumi Takamaru, Kazuya Akita, Takaharu Kudoh, Akira Takahashi and Youji Miyamoto : Computed tomography-based morphological analysis for intraoral vertical ramus osteotomy in patients with mandibular prognathism, Oral Science International, Vol.21, No.1, 37-45, 2023. (Link to Publication Site) ● Publication site (DOI): 10.1002/osi2.1176 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1176 (DOI: 10.1002/osi2.1176)
7.	Naoyuki Fukuda, Keiko Kudoh, Kazuya Akita, Natsumi Takamaru, 石川邦夫 and Youji Miyamoto : Comparison of bioresorbable bone substitutes, carbonate apatite and β-tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement., Oral Science International, Vol.20, No.2, 1-8, 2023. (Link to Publication Site) ● Publication site (DOI): 10.1002/osi2.1170 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1170 (DOI: 10.1002/osi2.1170)
8.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Naito Kurio, 石川邦夫 and Youji Miyamoto : Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure., Journal of Materials Science. Materials in Medicine, Vol.34, No.1, 2022. (Summary) Carbonate apatite (COAp) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using COAp granules is difficult because of their granular shape. Therefore, we fabricated COAp honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of COAp HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining COAp area and calcified bone area (newly formed bone) were estimated from the histological images. COAp area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, COAp HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the COAp HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the COAp HCBs. Some osteoclasts invaded the wall of COAp HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the COAp HCBs. These findings suggest that COAp HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The COAp HCB were gradually resorbed and replaced by newly formed bone. (Keyword) Animals / Rabbits / Porosity / Apatites / Bone Substitutes / Bone and Bones / Porifera (Tokushima University Institutional Repository) ● Metadata: 118064 (Link to Publication Site) ● Publication site (DOI): 10.1007/s10856-022-06710-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36586041 ● Summary page in Scopus @ Elsevier: 2-s2.0-85145354870 (Tokushima University Institutional Repository: 118064, DOI: 10.1007/s10856-022-06710-2, PubMed: 36586041, Elsevier: Scopus)
9.	Yoshiko Yamamura, Makoto Fukui, Takaharu Kudoh, 横田美保, Kumiko Kamada, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, Oral Care, Vol.16, No.2, 52-56, 2022. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520579212289190912 (CiNii: 1520579212289190912)
10.	Natsumi Takamaru, Naoyuki Fukuda, Kazuya Akita, Keiko Kudoh and Youji Miyamoto : Association of PD L1 and ZEB 1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma, Oncology Letters, Vol.23, No.3, 2022. (Summary) Programmed cell death-1 (PD-1) and its ligand programmed cell death 1 ligand 1 (PD-L1) are immune checkpoint inhibitors that play an important role in the host immune avoidance mechanism of tumors. The relationship between PD-L1 expression and malignancy has been reported in various types of cancer, such as lung and gastric cancer. In addition, epithelial-mesenchymal transition (EMT) of cancer cells is deeply involved in the invasion and metastasis of cancer. It has been reported that zinc finger E-box binding homeobox 1 (ZEB-1), an EMT inducer, contributes to metastasis in pancreatic and colon cancer. The present study aimed to investigate the relationship between the expression patterns of two markers, PD-L1 and ZEB-1, and clinicopathological characteristics and prognosis of oral squamous cell carcinoma (OSCC). Biopsy or surgical excision specimens from 169 patients with OSCC were used in the present study. Immunohistochemical staining with monoclonal anti-PD-L1 antibody and anti-ZEB-1 antibody was conducted. Cases with >1% tumor cells positive for PD-L1 and those with >10% tumor cells positive for ZEB-1 were considered positive, respectively. The findings revealed that individual expression of PD-L1 and ZEB-1 in OSCC was not associated with tumor size, degree of differentiation or Yamamoto-Kohama invasion pattern classification. However, co-expression of PD-L1 and ZEB-1 was associated with higher cervical lymph node metastasis and a lower survival rate. In conclusion, the results of the present study indicated that co-expression of PD-L1 and ZEB-1 could serve as a potential marker for the prognosis of patients with OSCC. (Link to Publication Site) ● Publication site (DOI): 10.3892/ol.2022.13195 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35111244 ● Summary page in Scopus @ Elsevier: 2-s2.0-85123294766 (DOI: 10.3892/ol.2022.13195, PubMed: 35111244, Elsevier: Scopus)
11.	Go Ohe, Yasusei Kudo, Kumiko Kamada, Yasuhiro Mouri, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : Soluble Factor from Oral Cancer Cell Lines Inhibits Interferon-γ Production by OK-432 via CD40/CD40Ligand Pathway, Cancers, Vol.13, No.13, 2021. (Tokushima University Institutional Repository) ● Metadata: 116508 (Link to Publication Site) ● Publication site (DOI): 10.3390/cancers13133301 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85108890231 (Tokushima University Institutional Repository: 116508, DOI: 10.3390/cancers13133301, Elsevier: Scopus)
12.	Akira Takahashi, Kumiko Kamada, Keiko Kudoh, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Evaluation of anatomical references for locating the course of the posterior superior alveolar artery for dental implant surgery, International Journal of Oral and Maxillofacial Surgery, Vol.51, No.2, 257-262, 2021. (Summary) This retrospective cohort study aimed to identify the best anatomical reference for predicting the posterior superior alveolar artery (PSAA) location. Computed tomographic images of 90 maxillary sinuses were evaluated. We studied five references, including the alveolar crest, maxillary sinus floor, zygomatoalveolar crest, hard palate and soft palate, and measured the distances between them and the PSAA. Variations in the distance were evaluated by the standard deviation and coefficient of variation (CV). The zygomatoalveolar crest was an unstable reference, owing to its high standard deviation and CV. The smallest CV was for the distance between the alveolar crest and PSAA, although the distance was smaller in edentulous jaws than dentulous jaws. The distance between the sinus floor and PSAA was larger in male and edentulous patients. The PSAA was detected in 40.0%, 44.4%, 54.4% and 56.7% of the sinus walls at the first and second premolar and the first and second molar positions, respectively. At these tooth positions, the respective heights above the hard palate were 11.2 ± 4.9, 8.2 ± 4.9, 6.2 ± 2.8 and 8.1 ± 2.9 mm. The hard palate was the most stable reference for predicting the location of the PSAA, irrespective of sex, age and dentition. (Keyword) Arteries / Cone-Beam Computed Tomography / Dental Implants / Humans / Male / Maxillary Sinus / Retrospective Studies / Sinus Floor Augmentation (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijom.2021.05.013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34083086 ● Summary page in Scopus @ Elsevier: 2-s2.0-85107155071 (DOI: 10.1016/j.ijom.2021.05.013, PubMed: 34083086, Elsevier: Scopus)
13.	Yoshiko Yamamura, Takamitsu Mano, Kumiko Kamada, 横田美保, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : A clinical study on malignant lymphomas arising in the oral region, Journal of Japan Society for Oral Tumors, Vol.33, No.2, 35-60, 2021. (Summary) We examined the clinical characteristics of 18 cases of malignant lymphomas arising in the oral region which were diagnosed at our department during the 11 years from 2008 to 2018. The patients consisted of 10 males and 8 females whose mean age was 70.2 years. The primary site was the upper gingiva in 10 cases (55.6%), and the initial symptoms were tumor mass and swelling in 15 cases (83.3%). Only 7 cases (38.9%) were clinically diagnosed as malignant lymphoma at first visit, but the other 11 cases were difficult to diagnose correctly. The various clinical symptoms such as mass formation and ulcer made differential diagnosis difficult, and a definitive diagnosis could not be obtained by only a single biopsy. Therefore, we examined whether blood test results might be used as an indicator of the diagnosis or not. Our results showed that LDH in 8 of 17 cases (47.1%) and sIL-2R in 11 of 16 cases (68.8%) were high values. Furthermore, we examined whether lymphocyte-monocyte ratio (LMR) helped the diagnosis or not. Thirteen of 17 cases (76.5%) showed a low value of LMR. There was a significant difference in LMR compared to non-malignant lymphoma patients. LMR in the blood tests was also considered to be a useful marker for the diagnosis. (Keyword) malignant lymphoma / clinical study / oral region / lymphocyte-monocyte ratio (Tokushima University Institutional Repository) ● Metadata: 116069 (Link to Publication Site) ● Publication site (DOI): 10.5843/jsot.33.35 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390851398293094784 ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.33.35 (Tokushima University Institutional Repository: 116069, DOI: 10.5843/jsot.33.35, CiNii: 1390851398293094784)
14.	Keiko Kudoh, Kazumi Takaishi, Takaharu Kudoh, Natsumi Takamaru, Kumiko Kamada and Youji Miyamoto : Inferior alveolar nerve paresthesia caused by the extrusion of calcium hydroxide-based paste into themandibular canal: A case report., Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.32, No.5, 366-369, 2020. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ajoms.2020.05.005 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2020.05.005 (DOI: 10.1016/j.ajoms.2020.05.005)
15.	Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Kazuya Akita, Takayuki Nakagawa and Youji Miyamoto : Expression of CD44,CD44v9ABCG2, CD24,Bmi-1 and ALDH1 in stage andoral spuamous cell carcinoma and their association with clinicopathological factors, Oncology Letters, Vol.16, No.1, 1133-1140, 2018. (Summary) Cancer stem cells (CSCs) exhibit self-replication, self-differentiation, drug resistance and immune evasion activities. In recent years CSCs have become increasingly important for the treatment of malignant tumors. CSCs express specific markers, including cluster of differentiation (CD)44, CD44 variant 9 (CD44v9), ATP-binding cassette sub-family G member 2 (ABCG2), CD24, B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) and aldehyde dehydrogenase 1 (ALDH1). However, the prognostic value of their expression in patients with oral squamous cell carcinoma (OSCC) are not well known. The present study evaluated these markers in stage I and II patients with OSCC and examined the association between T classification, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. Tissue specimens were obtained from 70 patients with stage I or II OSCC following either surgery or biopsy. Immunohistochemistry was performed and positive staining was defiend as 10% positive cells. CD44 and CD44v9 expressions were strongly detected in all OSCC tissues compared with normal epithelial cells. A total of 22 (31.4%) cases expressed ABCG2 and there was a significant association between ABCG2 expression and invasion. A total of 41 cases (59.0%) expressed CD24 and there was a significant association between CD24 expression and invasion. A total of 33 cases (47.1%) expressed BMI-1 and there was a significant association between BMI-1 expression and the disease-free survival rate. A total of 18 cases (25.7%) expressed ALDH1. Although there was no association between ALDH1 expression and T classification, there were significant associations between ALDH1 expression and histological differentiation, invasion mode, metastasis and the disease-free survival rate. Multivariate analysis revealed that ALDH1 expression was the only prognostic factor for disease-free survival rate. The results of the present study suggest that the positivity of ALDH1 detected in patients with OSCC correlates with the number of cells undergoing epithelial mesenchymal transition and metastasis. These findings indicated that the expression of ALDH1 may be an effective prognostic marker indicating the survival of patients with stage I and II OSCC. (Tokushima University Institutional Repository) ● Metadata: 113599 (Link to Publication Site) ● Publication site (DOI): 10.3892/ol.2018.8703 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29963189 ● Summary page in Scopus @ Elsevier: 2-s2.0-85047608360 (Tokushima University Institutional Repository: 113599, DOI: 10.3892/ol.2018.8703, PubMed: 29963189, Elsevier: Scopus)
16.	Shinya Sento, Naoya Kitamura, Tetsuya Yamamoto, Koichi Nakashiro, Hiroyuki Hamakawa, Soichiro Ibaragi, Akira Sasaki, Natsumi Takamaru, Youji Miyamoto, Isamu Kodani, Kazuo Ryoke, Katsuaki Mishima and Yoshiya Ueyama : Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients, Anticancer Research, Vol.37, No.12, 6977-6981, 2017. (Summary) To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases. (Keyword) Administration, Intravenous / Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Cisplatin / Drug Therapy, Combination / female / Humans / Isoquinolines / male / Middle Aged / Mouth Neoplasms / Nausea / Palonosetron / Quinuclidines / Serotonin Antagonists / Treatment Outcome / Vomiting (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.12165 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29187483 ● Summary page in Scopus @ Elsevier: 2-s2.0-85038130164 (DOI: 10.21873/anticanres.12165, PubMed: 29187483, Elsevier: Scopus)
17.	Keiko Kudoh, Kumiko Kamada, Natsumi Takamaru, Yoshiko Yamamura, Go Ohe, Takaharu Kudoh, Akira Takahashi, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : 徳島県における口腔がん検診の現状, 日本歯科人間ドック学会誌, Vol.12, No.1, 21-25, 2017.
18.	Natsumi Takamaru, Tetsuya Tamatani, Go Ohe, Yoshiko Yamamura, Keiko Kudoh and Youji Miyamoto : Single non-contact Nd: YAG laser irradiation treatment for venous malformations in the oral cavity, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.29, No.5, 415-419, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ajoms.2017.05.010 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2017.05.010 (DOI: 10.1016/j.ajoms.2017.05.010)
19.	Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Go Ohe, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Prevalence and imaging characteristics of palatine tonsilloliths evaluated on 2244 pairs of panoramic radiographs and CT images., Clinical Oral Investigations, Vol.21, No.1, 85-91, 2017. (Summary) Palatine tonsilloliths incidentally detected on diagnostic imaging should be differentiated from pathologic calcifications to enable correct diagnosis and treatment. The aim of this study is to clarify the prevalence and imaging characteristics of palatine tonsilloliths on panoramic radiographs. We retrospectively reviewed 2244 individuals who underwent pairs of consecutive panoramic radiography and computed tomography (CT) of the head and neck region. The imaging characteristics of palatine tonsilloliths on panoramic radiography were compared with the findings from CT, which was considered the gold standard. Tonsilloliths were detected in 300 (13.4 %) and 914 (40.7 %) of the 2244 individuals on panoramic radiographs and CT, respectively. On panoramic radiographs, tonsilloliths were superimposed over the ramus of the mandible at the level coincident with and inferior to the soft palate in 176 (7.8 %) and 90 (4.0 %) individuals, respectively. Tonsilloliths were also superimposed over the surrounding soft tissue inferior to the body of the mandible, postero-inferior to the angle of the mandible, and posterior to the ramus of the mandible in 33 (1.5 %), 26 (1.2 %), and 28 (1.3 %) individuals, respectively. A significant correlation was observed between the detectability on panoramic radiographs and the size (Spearman r = 1.000) and number (Spearman r = 0.991) of tonsilloliths, as revealed by CT images. The present results suggest that tonsilloliths are commonly detected on panoramic radiographs. Furthermore, they can be superimposed on both the mandible and the surrounding soft tissue. Clinicians should include tonsilloliths among the differential diagnoses when calcified bodies are detected on panoramic radiographs. (Tokushima University Institutional Repository) ● Metadata: 113566 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00784-016-1752-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26892471 ● Search Scopus @ Elsevier (PMID): 26892471 ● Search Scopus @ Elsevier (DOI): 10.1007/s00784-016-1752-0 (Tokushima University Institutional Repository: 113566, DOI: 10.1007/s00784-016-1752-0, PubMed: 26892471)
20.	Takaharu Kudoh, Hitoshi Ikushima, Keiko Kudoh, Shunsuke Furutani, Takashi Kawanaka, Akiko Kubo, Natsumi Takamaru, Tetsuya Tamatani and Youji Miyamoto : Effectiveness of Newly Developed Water-Equivalent Mouthpiece during External Beam Radiotherapy for Oral Cancer, Ann Carcinog, Vol.2, No.1, 2017. (Tokushima University Institutional Repository) ● Metadata: 113606 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570009752882329984 (Tokushima University Institutional Repository: 113606, CiNii: 1570009752882329984)
21.	Yoshiko Yamamura, Kenji Fujisawa, 鎌田久美子, Natsumi Takamaru, Keiko Kudoh, Go Ohe, Takaharu Kudoh, Akira Takahashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 口腔がん患者の歯科疾患罹患状況, 日本歯科人間ドック学会誌, Vol.11, No.1, 29-32, 2016.
22.	Kanae Hara, Kenji Fujisawa, Hirokazu Nagai, Natsumi Takamaru, Go Ohe, Kanji Tsuru, Kunio Ishikawa and Youji Miyamoto : Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam, Materials, Vol.9, No.9, 711, 2016. (Summary) Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam. (Tokushima University Institutional Repository) ● Metadata: 113607 (Link to Publication Site) ● Publication site (DOI): 10.3390/ma9090711 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28773832 ● Summary page in Scopus @ Elsevier: 2-s2.0-84988983311 (Tokushima University Institutional Repository: 113607, DOI: 10.3390/ma9090711, PubMed: 28773832, Elsevier: Scopus)
23.	Natsumi Takamaru, Hirokazu Nagai, Go Ohe, Tetsuya Tamatani, Kaori Sumida, Seiichiro Kitamura and Youji Miyamoto : Measurement of the zygomatic bone and pilot hole technique for safer insertion of zygomaticus implants, International Journal of Oral and Maxillofacial Surgery, Vol.45, No.1, 104-109, 2016. (Summary) The zygomaticus implant was developed for patients with severe bone resorption of the posterior maxilla. These may eliminate or minimize the need for bone grafting. Although the zygomaticus implant has shown a remarkable success rate in this difficult-to-treat patient population, the method requires an advanced surgical technique and carries an increased risk of complications. There have been few anatomical studies on the zygomatic bone in relation to the insertion of zygomaticus implants. The height and thickness of the zygomatic bone for the insertion were measured in this study. The thickness at the 90° angle point, where the upper margin of the zygomatic arch and the temporal margin of the frontal process of the zygomatic bone intersect and where the apex of the implant penetrates, was found to be 1.8±0.4 mm; this gradually increased inferiorly and anteriorly. Thus, the penetration point of the apex of the zygomaticus implant should be located more inferoanterior to the 90° angle point, as the thickness in this region is thinner than the diameter of the implant. Based on the results of this study, a newer and safer insertion method for the zygomaticus implant using a drill guide is proposed. (Tokushima University Institutional Repository) ● Metadata: 114011 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijom.2015.07.015 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26395065 ● Summary page in Scopus @ Elsevier: 2-s2.0-84952870149 (Tokushima University Institutional Repository: 114011, DOI: 10.1016/j.ijom.2015.07.015, PubMed: 26395065, Elsevier: Scopus)
24.	Hirokazu Nagai, Masako Fujioka-Kobayashi, Kenji Fujisawa, Go Ohe, Natsumi Takamaru, Kanae Hara, Daisuke Uchida, Tetsuya Tamatani, Kunio Ishikawa and Youji Miyamoto : Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells, Journal of Materials Science. Materials in Medicine, Vol.26, No.2, 99, 2015. (Summary) Carbonated apatite (CO3Ap) is the inorganic component of bone. We have proposed a new method for the fabrication of CO3Ap blocks based on a dissolution-precipitation method using a synthetic precursor. The aim of this study is to examine the effects of low crystalline CO3Ap on initial cell attachment, proliferation and osteoblastic differentiation of human bone marrow cells (hBMCs) using sintered hydroxyapatite and tissue culture plates as controls. Initial cell attachment and proliferation were assessed with a MTT assay. Expression of osteoblastic markers was examined by reverse transcription-polymerase chain reaction. XRD and FT-IR results showed formation of B-type carbonate apatite with lower crystallinity. No difference was observed for initial cell attachment between HAp and CO3Ap discs. hBMSC attached more significantly on tissue culture plate than on HAp and CO3Ap discs. The number of cells on HAp was higher than that on CO3Ap until day 7, after which the number of cells was similar. hBMSC proliferated more significantly on tissue culture plate than on HAp and CO3Ap discs. In contrast, hBMCs incubated on CO3Ap demonstrated much higher expression of osteoblastic markers of differentiation, such as type I collagen, alkaline phosphatase, osteopontin and osteocalcin, than hBMCs on HAp. On the tissue culture plate, they were not any change throughout the culture period. These results demonstrated that low crystalline CO3Ap exhibit higher osteoinductivity than HAp. (Keyword) Alkaline Phosphatase / Apatites / Biomarkers / Bone Marrow Cells / Bone Substitutes / Cell Adhesion / Cell Culture Techniques / cell differentiation / Cell Proliferation / Collagen Type I / crystallization / Durapatite / Humans / Materials Testing / Osteoblasts / Osteocalcin / Osteogenesis / osteopontin / Spectroscopy, Fourier Transform Infrared / X-ray diffraction (Link to Publication Site) ● Publication site (DOI): 10.1007/s10856-015-5431-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25655499 ● Summary page in Scopus @ Elsevier: 2-s2.0-84922324403 (DOI: 10.1007/s10856-015-5431-5, PubMed: 25655499, Elsevier: Scopus)
25.	Hirokazu Nagai, Masako Fujioka-Kobayashi, Go Ohe, Kanae Hara, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : Antitumour effect of valproic acid against salivary gland cancer in vitro and in vivo, Oncology Reports, Vol.31, No.3, 1453-1458, 2014. (Summary) Salivary gland cancer (SGC) has a comparatively poor prognosis and is prone to frequent recurrence and metastases. Therefore, the development of more effective chemotherapy against SGC is desirable. The aim of the present study was to investigate the antitumour effects of valproic acid (VPA) against SGC in vitro and in vivo. Two human SGC cell lines (HSY and HSG cells) were used in the present study. The effects of VPA on the proliferation of SGC cells in vitro were assessed by MTT assay. Cancer cells treated with VPA were subjected to cell cycle analysis by flow cytometry. In addition, the expression levels of p21 and p27 were examined by real-time RT-PCR to identify the mechanisms of the antitumour effect of VPA on SGC. The effects of VPA on cancer growth in vivo were evaluated in a xenograft model. VPA inhibited the proliferation of SGC cells in a dose-dependent manner in vitro. Degenerated cancer cells were observed at high concentrations of VPA. In the cell cycle analysis, VPA induced cell-growth inhibition and G1 arrest of cell cycle progression in both cancer cell lines in a time- and dose-dependent manner. VPA markedly upregulated the mRNA expression levels of both p21 and p27 in both SGC cell lines in a time-dependent manner. In the xenograft model experiment, VPA treatment markedly inhibited the growth of salivary gland tumours when compared with the growth of the untreated controls. VPA may be a valuable drug in the development of better therapeutic regimens for SGC. (Keyword) Adenocarcinoma / Animals / Antineoplastic Agents / Cell Line, Tumor / Cell Survival / Cyclin-Dependent Kinase Inhibitor p21 / Cyclin-Dependent Kinase Inhibitor p27 / Gene Expression / Humans / Mice / Mice, Inbred BALB C / Mice, Nude / Salivary Gland Neoplasms / Valproic Acid / Xenograft Model Antitumor Assays (Tokushima University Institutional Repository) ● Metadata: 113603 (Link to Publication Site) ● Publication site (DOI): 10.3892/or.2013.2959 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24398788 ● Summary page in Scopus @ Elsevier: 2-s2.0-84896709497 (Tokushima University Institutional Repository: 113603, DOI: 10.3892/or.2013.2959, PubMed: 24398788, Elsevier: Scopus)
26.	Nobuyuki Kuribayashi, Daisuke Uchida, Makoto Kinouchi, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : The Role of Metabotropic Glutamate Receptor 5 on the Stromal Cell-Derived Factor-1/CXCR4 System in Oral Cancer, PLoS ONE, Vol.8, No.11, e80773, 2013. (Summary) We have demonstrated that blocking CXCR4 may be a potent anti-metastatic therapy for CXCR4-related oral cancer. However, as CXCR4 antagonists are currently in clinical use to induce the mobilization of hematopoietic stem cells, continuous administration as an inhibitor for the metastasis may lead to persistent leukocytosis. In this study, we investigated the novel therapeutic downstream target(s) of the SDF-1/CXCR4 system, using B88-SDF-1 cells, which have an autocrine SDF-1/CXCR4 system and exhibit distant metastatic potential in vivo. Microarray analysis revealed that 418 genes were upregulated in B88-SDF-1 cells. We identified a gene that is highly upregulated in B88-SDF-1 cells, metabotropic glutamate receptor 5 (mGluR5), which was downregulated following treatment with 1,1' -[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD3100), a CXCR4 antagonist. The upregulation of mGluR5 mRNA in the SDF-1/CXCR4 system was predominately regulated by the Ras-extracellular signal-regulated kinase (ERK)1/2 pathway. Additionally, the growth of B88-SDF-1 cells was not affected by the mGluR5 agonist (S)-3,5-DHPG (DHPG) or the mGluR5 antagonists 2-Methyl-6-(phenylethynyl)pyridine (MPEP) and 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP). However, we observed that DHPG promoted B88-SDF-1 cell migration, whereas both MPEP and MTEP inhibited B88-SDF-1 cell migration. To assess drug toxicity, the antagonists were intraperitoneally injected into immunocompetent mice for 4 weeks. Mice injected with MPEP (5 mg/kg) and MTEP (5 mg/kg) did not exhibit any side effects, such as hematotoxicity, allergic reactions or weight loss. The administration of antagonists significantly inhibited the metastasis of B88-SDF-1 cells to the lungs of nude mice. These results suggest that blocking mGluR5 with antagonists such as MPEP and MTEP could prevent metastasis in CXCR4-related oral cancer without causing side effects. (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0080773 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24236200 ● Search Scopus @ Elsevier (PMID): 24236200 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0080773 (DOI: 10.1371/journal.pone.0080773, PubMed: 24236200)
27.	Tetsuya Tamatani, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor B activity in human oral cancer cells., International Journal of Oncology, Vol.42, No.3, 935-944, 2013. (Summary) Oral cancer cells have a significantly augmented nuclear factor-κB (NF-κB) activity and the inhibition of this activity suppresses tumor growth. Bortezomib is a proteasome inhibitor and a drug used for molecular-targeted therapy (targets NF-κB). In this study, we investigated whether bortezomib would be effective as an inhibitor of proliferation and a radiosensitizer for the treatment of oral cancer. We demonstrate that bortezomib inhibits NF-κB activity and cell proliferation. The combined treatment with bortezomib and radiation (RT) suppressed NF-κB activity and cell growth in vitro and in vivo compared with RT treatment alone. To investigate the mechanisms by which bortezomib suppresses tumor growth, the expression of signaling molecules downstream of NF-κB were examined by ELISA. The combined treatment significantly inhibited the radiation-induced production of angiogenic factors and decreased the number of blood vessels in the tumor tissues. Although the expression of anti-apoptotic proteins was upregulated by RT, bortezomib downregulated the RT-induced expression of these proteins. Moreover, the expression of cleaved poly(ADP-ribose) polymerase in vitro and in vivo was enhanced by bortezomib, indicating that bortezomib inhibits tumor growth by inducing apoptosis. This study clearly demonstrates that bortezomib significantly inhibits tumor growth and that the combined treatment with bortezomib and RT results in a significant inhibition of tumor growth. The mechanisms underlying the inhibition of tumor growth by bortezomib include the suppression of angiogenesis and the induction of apoptosis. A novel molecular targeting therapy including bortezomib may be effective in the treatment of oral cancer by suppressing NF-κB activity. (Keyword) Animals / Antineoplastic Agents / Apoptosis / Boronic Acids / Cell Line, Tumor / Cell Proliferation / Female / Humans / I-kappa B Proteins / Interleukin-6 / Interleukin-8 / Mice / Mice, Inbred BALB C / Mice, Nude / Mouth Neoplasms / NF-kappa B / Neoplasm Transplantation / Neovascularization, Pathologic / Poly(ADP-ribose) Polymerases / Pyrazines / Radiation-Sensitizing Agents / Transcription Factor RelA / Vascular Endothelial Growth Factor A / Xenograft Model Antitumor Assays (Tokushima University Institutional Repository) ● Metadata: 113601 (Link to Publication Site) ● Publication site (DOI): 10.3892/ijo.2013.1786 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23340716 ● Search Scopus @ Elsevier (PMID): 23340716 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2013.1786 (Tokushima University Institutional Repository: 113601, DOI: 10.3892/ijo.2013.1786, PubMed: 23340716)
28.	Natsumi Takamaru, Daisuke Uchida, Go Ohe, Hirokazu Nagai, Naozumi Ishimaru and Youji Miyamoto : A case of giant cell epulis accompanied by bone formation in the premolar region of the mandible, Japanese Journal of Oral & Maxillofacial Surgery, Vol.58, No.11, 651-654, 2012. (Summary) Giant cell epulis (peripheral giant cell granuloma) is a granuloma consisting of a large number of multinucleated giant cells. Its incidence is high in Europe and the United States, but is very low in Japan. Giant cell epulis accompanied by bone formation is extremely rare in Japan. We report a case of giant cell epulis accompanied by bone formation. A 46-year-old woman visited our hospital because of a mass in the left mandibular molar region. There was a well-demarcated, pedunculated mass in the left mandibular molar region. The mass was excised under the clinical diagnosis of epulis. Histopathologically, the resected specimen consisted of spindle cells resembling fibroblasts and many multinucleated giant cells. Moreover, newly synthesized bone was observed in the center of the mass. The pathological diagnosis was a giant cell granuloma. Two years six months after the operation, there has been no evidence of recurrence. (Keyword) giant cell epulis(巨細胞エプーリス) / giant cell epulis(キョサイボウエプーリス) / bone formation(骨形成) / bone formation(ホネケイセイ) (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.58.651 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282681509153536 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.58.651 (DOI: 10.5794/jjoms.58.651, CiNii: 1390282681509153536)
29.	Tetsuya Tamatani, Tarannum Ferdous, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells, International Journal of Oncology, Vol.41, No.3, 1148-1156, 2012. (Summary) Docetaxel (DOC) and 5-fluorouracil (5-FU) are important anticancer agents widely used in the treatment of a variety of cancers including oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the antitumor efficacy of the sequential administration of DOC and 5-FU against OSCC cells (B88 and CAL27 cells) in vitro and in vivo. In in vitro growth inhibition assays, sequential treatment with DOC followed by 5-FU was more effective in inhibiting cancer cell growth than 5-FU followed by DOC, single treatment with DOC or 5-FU, or combined treatment with DOC and 5-FU. Furthermore, DOC followed by 5-FU significantly inhibited tumor growth in vivo compared to 5-FU followed by DOC. To understand the mechanisms underlying the enhanced growth inhibitory effect of the administration sequence, DOC followed by 5-FU, we examined the expression of 5-FU metabolic enzymes such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT), which were known to regulate the antitumor effect of 5-FU, by real-time RT-PCR and western blot analysis. Downregulation of TS and DPD expression and upregulation of OPRT expression were induced by DOC treatment, suggesting that DOC enhanced the efficacy of 5-FU by altering the expression of its metabolic enzymes. These results indicate that sequential treatment with DOC followed by 5-FU could be a promising therapeutic strategy for oral cancer. (Keyword) Animals / Antineoplastic Combined Chemotherapy Protocols / Cell Line, Tumor / Dihydrouracil Dehydrogenase (NADP) / Down-Regulation / Fluorouracil / Humans / Mice / Mice, Nude / Mouth Neoplasms / Orotate Phosphoribosyltransferase / Taxoids / Thymidylate Synthase / Up-Regulation / Xenograft Model Antitumor Assays (Tokushima University Institutional Repository) ● Metadata: 113602 (Link to Publication Site) ● Publication site (DOI): 10.3892/ijo.2012.1544 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22766915 ● Search Scopus @ Elsevier (PMID): 22766915 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2012.1544 (Tokushima University Institutional Repository: 113602, DOI: 10.3892/ijo.2012.1544, PubMed: 22766915)
30.	Hirokazu Nagai, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Seiji Iwamoto and Youji Miyamoto : [Evaluation of Combination Chemotherapy with Oral S-1 Administration Followed by Docetaxel by Superselective Intra-Arterial Infusion for Patients with Oral Squamous Cell Carcinomas.], Japanese Journal of Cancer and Chemotherapy, Vol.38, No.5, 777-781, 2011. (Summary) The purpose of this study was to evaluate the effectiveness and adverse events of combination chemotherapy with oral S-1 administration following docetaxel(DOC)treatment by superselective intra-arterial infusion as neo-adjuvant chemotherapy (NAC)for patients with oral squamous cell carcinoma. Thirteen patients were enrolled in this study(9 men and 4 women, with a mean age of 61. 0 years). All patients were given S-1 65mg/m / 2 per day for 14 days, and DOC 40-50mg/m2 by intraarterial infusion was administered. The locoregional response evaluated 3 weeks after administration was 100%, including a 69. 2% complete response. According to Oboshi and Shimosato's classification, histological evaluation of surgical specimens revealed that 3 cases were Grade IIa, 4 cases Grade IIb, 1 case Grade IVa, and 4 cases Grade IVc. The severe side effects were neutropenia and cerebral infarction. The present study suggests that combination chemotherapy with S-1 and DOC by superselective intra-arterial infusion would be an effective and safe regimen in NAC for oral squamous cell carcinomas. (Keyword) Administration, Oral / Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Cerebral Infarction / Drug Combinations / Female / Humans / Infusions, Intra-Arterial / Male / Middle Aged / Mouth Neoplasms / Neoplasm Staging / Neutropenia / Oxonic Acid / Taxoids / Tegafur (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21566436 ● Summary page in Scopus @ Elsevier: 2-s2.0-79960998915 (PubMed: 21566436, Elsevier: Scopus)
31.	Kazumi Takaishi, Shigemasa Tomioka, Satoru Eguchi, NAKAI Megumi, IWATA Hidemichi, ENOMOTO Nami, Natsumi Takamaru and Hiroshi Kitahata : A retrospective survey of conscious sedation used in children undergoing oral surgery or dental treatment during e ten-year period at the Tokushima University Hospital, Journal of Japanese Dental Society of Anesthesiology, Vol.38, No.2, 176-179, 2010. (Keyword) SEDATION / children / INTRAVENOUS / INHALATION / PREMEDICATION (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571980075955865728 (CiNii: 1571980075955865728)
32.	Natsumi Takamaru : 分子標的薬bortezomibを用いた口腔癌に対する新規治療法の開発, Shikoku Dental Research, Vol.21, No.1, 65-81, 2008.
33.	Tetsuya Tamatani, Masayuki Azuma, Katsumi Motegi, Natsumi Takamaru, Yuichiro Kawashima and Takashi Bando : Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells., International Journal of Oncology, Vol.31, No.4, 761-768, 2007. (Summary) We have already demonstrated that human head and neck cancer cells have significantly enhanced levels of transcription factor nuclear factor (NF)-kappaB activity compared to their normal counterparts, suggesting that NF-kappaB plays an important role in the development of head and neck cancer. However, it has been reported that chemotherapeutic agents and radiation activate NF-kappaB activity in cancer cells, thus making the cells radioresistant and chemoresistant. In addition, we have shown that the suppression of NF-kappaB activity enhanced apoptosis in oral squamous cell carcinoma cells. In this study, we examined whether cepharanthin-induced inhibition of NF-kappaB activity enhances radiosensitivity in human oral carcinoma cells. Cepharanthin is a biscoclaurine alkaloid extracted from the roots of Stephania cepharantha hayata, and is widely used in Japan for the treatment of patients with leucopenia, nasal allergy, and venomous snakebites. gamma-irradiation (IR) induces NF-kappaB activity in oral carcinoma cells through the activation of upstream molecules, including Akt and IkappaB kinase. However, a luciferase assay revealed that cepharanthin suppresses IR-induced NF-kappaB activity in oral squamous cell carcinoma cells, thereby enhancing the radio-sensitivity. Western blot analysis showed an enhanced cleavage of poly-(ADP-ribose) polymerase protein in carcinoma cells by both cepharanthin treatment and IR exposure compared to IR or cepharanthin alone. In an in vivo study, B88 cells were s.c. inoculated into the backs of nude mice. Tumor-bearing nude mice received either cepharanthin, IR alone, or a combination of cepharanthin and IR. The combined treatment suppressed tumor growth significantly more than either cepharanthin or IR alone. Cepharanthin inhibited the production of IR-induced IL-6 and IL-8, which are downstream targets of NF-kappaB. In quantitative real-time RT-PCR, IR also induced the expression of anti-apoptotic proteins [cellular inhibitor of apoptosis protein (cIAP)-1 and -2] in carcinoma cells. Treatment of cancer cells with cepharanthin combined with exposure to IR decreased cIAP-1 and -2 mRNA expression. These findings suggested that the combination of radiotherapy and cepharanthin could enhance radiosensitivity in the treatment of human oral cancer. (Keyword) Alkaloids / Animals / Apoptosis / Benzylisoquinolines / Blotting, Western / Carcinoma, Squamous Cell / Cell Line, Tumor / Fluorescent Antibody Technique / Gamma Rays / Humans / I-kappa B Kinase / Inhibitor of Apoptosis Proteins / Interleukin-6 / Interleukin-8 / Luciferases / Mice / Mice, Inbred BALB C / Mice, Nude / Mouth Neoplasms / NF-kappa B / RNA, Messenger / Radiation, Ionizing / Radiation-Protective Agents (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17786306 ● Summary page in Scopus @ Elsevier: 2-s2.0-35848957914 (PubMed: 17786306, Elsevier: Scopus)
34.	Tetsuya Tamatani, Masayuki Azuma, Katsumi Motegi, Yuki ASHIDA, Natsumi Takamaru, Takashi Bando, Hideo Yoshida and Mitsunobu Sato : Enhanced radiosensitization by cepharanthin in human oral squamous carcinoma cells : Inhibition of NF-κB as a molecular target, Journal of The Japanese Stomatological Society, Vol.54, No.2, 230-236, 2005. (Keyword) Cepharanthin / Radiosensitization / NF-κB (Link to Publication Site) ● Publication site (DOI): 10.11277/stomatology1952.54.230 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520290883462556800 ● Search Scopus @ Elsevier (DOI): 10.11277/stomatology1952.54.230 (DOI: 10.11277/stomatology1952.54.230, CiNii: 1520290883462556800)

Review, Commentary:

1.	Youji Miyamoto, Naito Kurio, Keiko Kudoh and Natsumi Takamaru : -, Journal of Japanese Society of Oral Implantology, Vol.34, No.1, 26-32, Mar. 2021. (Keyword) 歯科インプラント / 医療事故 / 手術手技 / dental implant / medical accident / operative procedure (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.34.26 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390287827491626624 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.34.26 (DOI: 10.11237/jsoi.34.26, CiNii: 1390287827491626624)
2.	Youji Miyamoto, Keiko Kudoh, Go Ohe and Natsumi Takamaru : 再生療法の最前線 Ⅴ．サイトランスグラニュールを用いた上顎洞底挙上術の長期経過, The Nippon Dental Review, Vol.79, No.9, 68-73, Aug. 2019.
3.	Youji Miyamoto, Tetsuya Tamatani, Go Ohe, Natsumi Takamaru, Keiko Kudoh, Yoshiko Yamamura, Kenji Fujisawa and Hirokazu Nagai : Novel Concepts of Surgery and Progress of Operative Procedure, Journal of Oral Health and Biosciences, Vol.29, No.1, 7-12, Jun. 2016. (Summary) Although the recent progress in surgery is remarkable, many dentists do not recognize it enough. From three viewpoints, we introduce and exposit new concept of treatment for wound, device (instrument) for arrest of hemorrhage, and operation procedure by surgical knife. It is always important for dentists to continue taking in new knowledge and techniques. (Keyword) 創傷処置 / 消毒 / 手術時手洗い / エナジーデバイス (Tokushima University Institutional Repository) ● Metadata: 109747 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050583647831063808 (Tokushima University Institutional Repository: 109747, CiNii: 1050583647831063808)

Proceeding of International Conference:

1.	Tetsuya Tamatani, Natsumi Takamaru, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : Expression of SOX2 and Oct4 in human oral squamous cell carcinoma and its relationship with clinical factors, AACR Annual Meeting 2017, Apr. 2017.
2.	Tetsuya Tamatani, Natsumi Takamaru, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : Expression of ALDH1, Bmi-1 and CD24 in human oral squamous cell carcinoma and its relationship with clinical factors, AACR Annual Meeting 2016, Apr. 2016.
3.	Natsumi Takamaru, Tetsuya Tamatani, Daisuke Uchida, Nobuyuki Kuribayashi, Go Ohe, Hirokazu Nagai and Youji Miyamoto : Clinicopathological Evaluation of Late cervical Lymph Node Metastatsis fo Oral Squamous Cell Carcinoma, American association of Oral Maxillofacial Surgeons(aaoms) 96th Annual Meeting, scientific Sessions & Exhibition, Sep. 2014.
4.	Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai and Youji Miyamoto : Express of ABCG2, ALDH1A1, CD44, and CD44 variant 9 in human oral squamous cell carcinoma and its relationship with clinical factors., AACR Annual Meeting 2014, Apr. 2014.
5.	Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : The expression of nuclear factor-B in human oral squamous cell carcinoma and its relationship with clinical factors, AACR Annual Meeting 2013, Apr. 2013.
6.	Tetsuya Tamatani, Natsumi Takamaru, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : The expression of X-linked inhibitor of apoptosis in human oral squamous cell carcinoma and its relationship with clinical factors, American Associattion for Cancer Research Annual Meeting 2012, Apr. 2012.

Proceeding of Domestic Conference:

1.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, Keiko Kudoh and Naito Kurio : 顎骨嚢胞摘出後の骨欠損再建に使用した炭酸アパタイト骨補填材の評価, 第69回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2024.
2.	Naito Kurio, Kumiko Kamada, Naoyuki Fukuda and Natsumi Takamaru : 顎変形症の術後管理中に解離性てんかん発作を発症した一例, 第34回日本顎変形症学会総会・学術大会, Jun. 2024.
3.	Akira Takahashi, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, 日本歯科放射線学会第64回学術大会, Vol.64, 40, May 2024. (Keyword) computed tomography / dental implants / floor of the mouth / lingual perimandibular vessels / oral hemorrhage / postoperative bleeding / sublingual artery
4.	Takaharu Kudoh, Keiko Kudoh, Natsumi Takamaru, Akira Takahashi, Naito Kurio, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Youji Miyamoto and Hitoshi Ikushima : Unilateral Neck Volumetric-Modulated Arc Therapy, 日本歯科放射線学会第64回学術大会, May 2024.
5.	Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 顎骨嚢胞摘出後に炭酸アパタイト骨補填材を充填した2例, 第27回日本顎顔面インプラント学会総会・学術大会, Dec. 2023.
6.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 操作・保持性を向上した炭酸アパタイト・コラーゲンスポンジの開発と骨再建への応用, 第27回日本顎顔面インプラント学会総会・学術大会, Dec. 2023.
7.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Takaharu Kudoh, Naito Kurio and Youji Miyamoto : 炭酸アパタイト製骨補填材の炭酸基量を変えることによる吸収性と骨新生のコントロール, 第68回日本口腔外科学会総会・学術大会, Nov. 2023.
8.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : インプラント治療を前提とした炭酸アパタイト骨補填材を用いた骨増生法の提案, 第43回日本口腔インプラント学会中国・四国支部学術大会, Oct. 2023.
9.	Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 顎骨嚢胞摘出後の骨欠損に使用した炭酸アパタイト骨補填材の長期経過, 第43回日本口腔インプラント学会近畿・北陸支部学術大会, Oct. 2023.
10.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイト骨補填材の歯槽骨造成術への応用, 第43回日本口腔インプラント学会近畿・北陸支部学術大会, Oct. 2023.
11.	野上幸裕, Naoyuki Fukuda, Kazuya Akita, 浦田豊彰, Natsumi Takamaru, Takaharu Kudoh, Akira Takahashi and Youji Miyamoto : 下顎のエナメル上皮腫と歯原性角化嚢胞のCTによる画像診断学的検討, 第70回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2023.
12.	Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイトハニカムブロックによる新規骨再建・骨造成法の開発, 第53回公益社団法人日本口腔インプラント学会学術大会, Sep. 2023.
13.	Natsumi Takamaru, Naoyuki Fukuda, Naito Kurio and Youji Miyamoto : 顎矯正手術患者の術後悪心嘔吐に対するオンダンセトロンの有用性の検討, 第33回特定非営利活動法人日本顎変形症学会総会・学術大会, Jun. 2023.
14.	Keiichiro Watanabe, Emiko Nakaue, Kumiko Kamada, Natsumi Takamaru, Naito Kurio and Eiji Tanaka : 3DシミュレーションとCAD/CAMスプリントを用いて上下顎移動術を施行した顎偏位を伴う骨格性下顎前突の1例, The Japanese Journal of Jaw Deformities, Vol.33, No.2, 174, May 2023. (Keyword) 顎前突症(合併症, 外科的療法, 診断) / スプリント, 不正咬合-アングルIII級(合併症, 外科的療法, 診断) / コンピュータ支援設計, コンピュータシミュレーション / 三次元イメージング, 顎矯正手術 / ヒト; 成人(19∼44); 女; 歯学
15.	Kazuya Akita, Natsumi Takamaru, Naoyuki Fukuda, Hiroaki Urata and Youji Miyamoto : 術後再発をきたしたセメント芽細胞腫の1例, 第77回NPO法人日本口腔科学会学術集会, May 2023.
16.	浦田豊彰, Natsumi Takamaru, Naoyuki Fukuda, Kazuya Akita and Youji Miyamoto : 当科におけるメトトレキサート関連リンパ増殖性疾患(MTX-LPD)の臨床的検討, 第51回口腔外科学会中国四国支部学術集会(WEB開催), Dec. 2022.
17.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸含有量が多孔質炭酸アパタイト顆粒の骨置換性に及ぼす影響, 第26回日本顎顔面インプラント学会総会, Nov. 2022.
18.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, 石川邦夫 and Youji Miyamoto : 炭酸含有量を調整した多孔質炭酸アパタイト顆粒による骨形成と吸収能の制御, 第44回日本バイオマテリアル学会大会, Nov. 2022.
19.	Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : 炭酸アパタイト製骨補填材を用いた上顎洞底挙上術後の長期予後について, 公益社団法人日本口腔インプラント学会第42回中国・四国支部学術大会, Nov. 2022.
20.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Takaharu Kudoh, Keiko Kudoh, Naito Kurio and Youji Miyamoto : 炭酸基量の異なる多孔質炭酸アパタイト顆粒の開発と骨再建, 第67回日本口腔外科学会総会・学術集会, Nov. 2022.
21.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, Keiko Kudoh, Takaaki Tsunematsu, Naozumi Ishimaru and Youji Miyamoto : 超選択的動脈塞栓術を併用して治療した上顎中心性巨細胞肉芽腫の1例, 第67回日本口腔外科学会総会・学術大会, Nov. 2022.
22.	Natsumi Takamaru, Naoyuki Fukuda, Kazuya Akita, Keiko Kudoh and Youji Miyamoto : 3次元網状連通気孔を有する炭酸アパタイトブロックの開発, 第67回日本口腔外科学会総会・学術大会, Nov. 2022.
23.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio and Youji Miyamoto : ハニカム構造を有する炭酸アパタイト多孔体によるウサギ下顎骨再建への応用, 第67回日本口腔外科学会総会・学術大会, Nov. 2022.
24.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : Fabrication of carbonate apatite granules and collagen composites for new bone substitute and bone regeneration, 第52回公益社団法人日本口腔インプラント学会学術大会, Sep. 2022.
25.	Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイトハニカムブロックによる新規骨造成法の開発, 第52回公益社団法人日本口腔インプラント学会学術大会, Sep. 2022.
26.	TANAKA Mariko, Shinya Horiuchi, Masahiro Hiasa, Keiichiro Watanabe, Akihiko Iwasa, Natsumi Takamaru, Hirokazu Nagai, Youji Miyamoto and Eiji Tanaka : 術後に顎関節に変調をきたした顎偏位を伴う骨格性上顎前突症例, 第32回日本顎変形症学会総会・学術大会, Vol.32, No.2, 171, Jun. 2022.
27.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイトハニカムブロックの開発と外側性骨造成への応用, 第76回NPO法人日本口腔科学会学術集会, Apr. 2022.
28.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Takaharu Kudoh, Keiko Kudoh, Naito Kurio, Akira Takahashi and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)の歯槽骨造成術およびソケットプリザベーションへの応用, 第50回(公社)日本口腔外科学会中国四国支部学術集会, Jan. 2022.
29.	Kumiko Kamada, Naito Kurio, Atsushi Uesugi, 横田美保, Kazuya Akita, Naoyuki Fukuda, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Akira Takahashi and Youji Miyamoto : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, Jan. 2022.
30.	Kazuya Akita, Naoyuki Fukuda, MUKUMOTO Shuhei, Natsumi Takamaru, Keiko Kudoh, 都留寛治, 石川邦夫 and Youji Miyamoto : 炭酸基含有量の異なる多孔質炭酸アパタイト顆粒の開発, 第51回公益財団法人日本口腔インプラント学会学術大会, Dec. 2021.
31.	Naoyuki Fukuda, Kazuya Akita, MUKUMOTO Shuhei, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイト製骨補填材による広範囲骨欠損の即時再建, 第51回公益財団法人日本口腔インプラント学会学術大会, Dec. 2021.
32.	Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイトハニカムブロックを用いたベニアグラフトの実験的検討, 第25回公益社団法人日本顎顔面インプラント学会総会・学術大会, Dec. 2021.
33.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Atsushi Uesugi, Yoshiko Yamamura, Takaharu Kudoh, Natsumi Takamaru, Keiko Kudoh, Naito Kurio, Akira Takahashi and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, Nov. 2021.
34.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, MUKUMOTO Shuhei, Keiko Kudoh and Youji Miyamoto : 嚢胞摘出後の骨欠損を炭酸アパタイト製骨補填材で即時再建した1例, 第66回日本口腔外科学会総会・学術大会, Nov. 2021.
35.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, MUKUMOTO Shuhei, Keiko Kudoh and 宮本洋二 : 嚢胞摘出後の骨欠損を炭酸アパタイト製骨補填材で即時再建した1例, 第43回日本バイオマテリアル学会, Nov. 2021.
36.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, 椋本修平, Natsumi Takamaru, Naito Kurio, Kumiko Kamada and Youji Miyamoto : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の開発, 第66回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2021.
37.	MUKUMOTO Shuhei, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランスグラニュール)の嚢胞摘出術への応用, 第49回(公社)日本口腔外科学会中国四国支部学術大会, Feb. 2021.
38.	Natsumi Takamaru, Naoyuki Fukuda, Kumiko Kamada, Kazuya Akita, Go Ohe, Naito Kurio and Youji Miyamoto : 早期口腔扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, 第65回日本口腔外科学会総会・学術大会, Nov. 2020.
39.	Naoyuki Fukuda, Keiko Kudoh, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Go Ohe, Naito Kurio and Youji Miyamoto : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの開発と顎骨再建への応用, 第65回日本口腔外科学会総会・学術大会, Nov. 2020.
40.	Naoyuki Fukuda, Kazuya Akita, 椋本修平, Natsumi Takamaru, Keiko Kudoh and Youji Miyamoto : 新規骨補填材としてのβ型リン酸三カルシウム顆粒セメントの開発と垂直的骨造成への応用, 第50回公益社団法人日本口腔インプラント学会記念学術大会, Sep. 2020.
41.	Natsumi Takamaru, Tetsuya Tamatani, 鎌田久美子, 秋田和也, Naito Kurio, Takayuki Nakagawa, Go Ohe and Youji Miyamoto : 舌扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, Nov. 2018.
42.	Yoshiko Yamamura, Tetsuya Tamatani, Keiko Kudoh, Kumiko Kamada, Takaharu Kudoh, Naito Kurio, Go Ohe, Natsumi Takamaru and Youji Miyamoto : 唾液腺の委縮により誘導される遺伝子およびマイクロRNA 発現の変化, 第63回日本口腔外科学会総会・学術大会, Nov. 2018.
43.	横田美保, Go Ohe, Tetsuya Tamatani, 秋田和也, 鎌田久美子, Natsumi Takamaru, Naito Kurio, 大塚邦紘, Yasusei Kudo and Youji Miyamoto : 当科におけるエナメル上皮腫の臨床統計学的検討, 第47回(公社)日本口腔外科学会中国四国支部学術集会, Jun. 2018.
44.	鎌田久美子, Naito Kurio, Keiko Kudoh, Takayuki Nakagawa, Go Ohe, 秋田和也, Naoyuki Fukuda, Natsumi Takamaru, Tetsuya Tamatani, Takamitsu Mano and Youji Miyamoto : 炭酸アパタイト顆粒(サイトランス○REAグラニュール)の上顎洞底挙上術への応用 -インプラント体同時埋入症例-, 第47回(公社)日本口腔外科学会中国四国支部学術集会, Jun. 2018.
45.	Natsumi Takamaru, Tetsuya Tamatani, Takamitsu Mano and Youji Miyamoto : 口腔扁平上皮癌におけるPD-L1発現と予後の検討, 第36回日本口腔腫瘍学会総会・学術大会, Jan. 2018.
46.	Keiko Kudoh, Takaharu Kudoh, Tetsuya Tamatani, Yoshiko Yamamura, Natsumi Takamaru, Go Ohe, Akira Takahashi, Kenji Fujisawa, 横田美保, 鎌田久美子 and Youji Miyamoto : 当科における口腔扁平苔癬症例の臨床的検討, 日本歯科人間ドック学会第20 回学術大会, Dec. 2017.
47.	鎌田久美子, Kenji Fujisawa, Keiko Kudoh, Takayuki Nakagawa, Go Ohe, Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Tetsuya Tamatani, Takamitsu Mano and Youji Miyamoto : 低結晶性炭酸アパタイト顆粒の上顎洞底挙上術への応用徳島大学病院におけるインプラント体同時埋入法の治験症例について, 日本顎顔面インプラント学会総会・学術大会, Dec. 2017.
48.	秋田和也, Kenji Fujisawa, Naoyuki Fukuda, Go Ohe, Natsumi Takamaru, 都留寛治, 石川邦夫 and Youji Miyamoto : 低結晶性炭酸アパタイト顆粒の顎骨再建への応用 –イヌ顎骨に埋植したインプラント体周囲における組織学的検討-, 日本口腔インプラント学会第37回中国・四国支部学術大会, Nov. 2017.
49.	Naoyuki Fukuda, 秋田和也, 鎌田久美子, Natsumi Takamaru, Takayuki Nakagawa, Go Ohe, Kenji Fujisawa and Youji Miyamoto : 硬化遅延材としてのクエン酸が自己硬化型β-TCP顆粒セメントに及ぼす影響, 日本口腔インプラント学会第37回中国・四国支部学術大会, Nov. 2017.
50.	Youji Miyamoto, 鎌田久美子, Yoshiko Yamamura, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Kenji Fujisawa and Takamitsu Mano : 頸部郭清術術後のリンパ漏・乳糜漏への対応, 第65回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2017.
51.	鎌田久美子, Natsumi Takamaru, Keiko Kudoh, Yoshiko Yamamura, Go Ohe, Tetsuya Tamatani, Takamitsu Mano and Youji Miyamoto : 特発性血小板減少性紫斑病を有する口底癌患者の治療経験, 第65回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2017.
52.	Yoshiko Yamamura, Tetsuya Tamatani, Takaharu Kudoh, 鎌田久美子, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Kenji Fujisawa, Takayuki Nakagawa, Naito Kurio, Takamitsu Mano and Youji Miyamoto : 放射線治療患者におけるピロカルピン塩酸塩を用いた口腔リンス法の有用性, 第16回中国四国口腔癌研究会, Nov. 2017.
53.	Natsumi Takamaru, Hirokazu Nagai, Kazuya Akita, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : 翼突下顎隙に生じた紡錐細胞脂肪腫の1例, 第62回日本口腔外科学会学術大会, Oct. 2017.
54.	Yoshiko Yamamura, Tetsuya Tamatani, Keiko Kudoh, Naoyuki Fukuda, Takayuki Nakagawa, Natsumi Takamaru, Go Ohe, Kenji Fujisawa and Youji Miyamoto : チタン上で培養したマウス骨芽細胞様細胞の硬組織分化にグルコース濃度が及ぼす影響, 第62回日本口腔外科学会学術大会, Oct. 2017.
55.	Go Ohe, Natsumi Takamaru, Takayuki Nakagawa, Tetsuya Tamatani, Kazuya Akita and Youji Miyamoto : 免疫チェックポイント阻害剤抗PD-L1抗体とOK-432の併用による口腔癌に対する抗腫瘍効果, 第62回日本口腔外科学会学術大会, Oct. 2017.
56.	Kenji Fujisawa, 秋田和也, Naoyuki Fukuda, Go Ohe, Natsumi Takamaru, 都留寛治, 石川邦夫 and Youji Miyamoto : 低結晶性炭酸アパタイト顆粒の骨再生への応用 –ウサギ大腿骨内における組織学的検討‐, 第47回日本口腔インプラント学会学術大会, Sep. 2017.
57.	横田美保, Keiko Kudoh, Tetsuya Tamatani, 鎌田久美子, Naoyuki Fukuda, Natsumi Takamaru, Yoshiko Yamamura, Takayuki Nakagawa, Go Ohe, Takaharu Kudoh, Akira Takahashi, Kenji Fujisawa, 鯨岡聡子, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : 当科における歯原性角化嚢胞の臨床的検討, 第46回日本口腔外科学会中国四国学術集会, May 2017.
58.	Kazuya Akita, Natsumi Takamaru, Tetsuya Tamatani, 鎌田久美子, Yoshiko Yamamura, Keiko Kudoh, Go Ohe, Kenji Fujisawa and Youji Miyamoto : 当科における手術拒否口腔癌症例の臨床的検討, 第46回日本口腔外科学会中国四国学術集会, May 2017.
59.	Akira Takahashi, Takaharu Kudoh, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Kenji Fujisawa, Chieko Sugawara and Youji Miyamoto : 咽頭扁桃結石に関するX線診断学的検討, 第71回NPO法人日本口腔科学会学術集会, Apr. 2017.
60.	Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Akira Takahashi, Kenji Fujisawa and Youji Miyamoto : 早期口腔扁平上皮癌患者におけるABCG2，ALDH1，Bmi-1，CD24およびCD44発見に関する検討, 第71回NPO法人日本口腔科学会学術集会, Apr. 2017.
61.	Yoshiko Yamamura, Kenji Fujisawa, Takaharu Kudoh, Keiko Kudoh, 秋田和也, 中村勇貴, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani and Youji Miyamoto : ピロカルピン塩酸塩(サラジェン)を用いた口腔リンス法の有効性と安全性の検討, 第14回日本口腔ケア学会総会・学術大会, Apr. 2017.
62.	Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 早期口腔扁平上皮癌患者におけるCD20の発現に関する検討, 第35回日本口腔腫瘍学会総会・学術大会, Jan. 2017.
63.	Keiko Kudoh, 鎌田久美子, 横田美保, Natsumi Takamaru, Yoshiko Yamamura, Go Ohe, Takaharu Kudoh, Akira Takahashi, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 当科における口腔がん検診の現況, 日本歯科人間ドック学会第19回学術大会, Dec. 2016.
64.	Yoshiko Yamamura, Tetsuya Tamatani, Go Ohe, Kenji Fujisawa, Natsumi Takamaru, Keiko Kudoh, Hirokazu Nagai and Youji Miyamoto : チタン上で培養したヒト骨髄間葉系幹細胞の遺伝子およびmicroRNA発現の解析, 第61回(公社)日本口腔外科学会総会・学術大会, Nov. 2016.
65.	Natsumi Takamaru, 鎌田久美子, Keiko Kudoh, Tetsuya Tamatani, Yoshiko Yamamura, Go Ohe, Hirokazu Nagai and Youji Miyamoto : 口腔内に発生したメトトレキサート関連リンパ増殖性疾患の2例, 第61回(公社)日本口腔外科学会総会・学術大会, Nov. 2016.
66.	Yoshiko Yamamura, Tetsuya Tamatani, Go Ohe, Kenji Fujisawa, Natsumi Takamaru, Keiko Kudoh, Hirokazu Nagai and Youji Miyamoto : チタンが培養ヒト骨髄間葉系幹細胞に及ぼす影響 –マイクロアレイによる解析-, 日本バイオマテリアル学会シンポジウム2016, Nov. 2016.
67.	Kamata Kumiko, Akira Takahashi, Go Ohe, Natsumi Takamaru, Kenji Fujisawa, Hirokazu Nagai, Susumu Abe and Youji Miyamoto : CT画像による副オトガイ孔の発現頻度に関する検討, 日本口腔インプラント学会中国・四国歯部学術大会, 33, Nov. 2016.
68.	Tetsuya Tamatani, Natsumi Takamaru, 鎌田久美子, 横田美保, Yoshiko Yamamura, Keiko Kudoh, Go Ohe, Takaharu Kudoh, Akira Takahashi, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 当科における早期口腔扁平上皮癌患者の臨床的検討, 第64回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2016.
69.	横田美保, Kenji Fujisawa, Yoshiko Yamamura, Tetsuya Tamatani, Natsumi Takamaru, Keiko Kudoh, Go Ohe, Hirokazu Nagai, 鯨岡聡子, Naozumi Ishimaru and Youji Miyamoto : 骨破壊を伴った顎放線菌症の2例, 第64回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2016.
70.	Akira Takahashi, 鎌田久美子, Yoshiko Yamamura, Natsumi Takamaru, Takaharu Kudoh, Keiko Kudoh, Go Ohe, Kenji Fujisawa, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 口腔扁平上皮癌の頸部リンパ節転移診断におけるFDG-PET検査の有用性, 第15回中国四国口腔癌研究会, Oct. 2016.
71.	Tetsuya Tamatani, Natsumi Takamaru, Hirokazu Nagai and Youji Miyamoto : 口腔扁平上皮癌におけるSOX2発現の臨床病理学的意義, 第75回日本癌学会学術大会総会, Oct. 2016.
72.	Kenji Fujisawa, Hirokazu Nagai, Natsumi Takamaru, 都留寛治, 石川邦夫 and Youji Miyamoto : 低結晶性炭酸アパタイトのインプラント領域への応用 –イヌ顎骨への印プラント体との同時埋植-, 第46回公益社団法人日本口腔インプラント学会学術大会, Sep. 2016.
73.	Kumiko Kamada, Keiko Kudoh, Tetsuya Tamatani, Natsumi Takamaru, Yoshiko Yamamura, Go Ohe, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 舌に発生したメトトレキサート関連リンパ増殖性疾患の1例, 第45回(公社)日本口腔外科学会中国四国支部学術大会, May 2016.
74.	Go Ohe, Kumiko Kamada, Natsumi Takamaru, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 頬粘膜に発生した基底細胞腺腫の1例, 第45回(公社)日本口腔外科学会中国四国支部学術大会, May 2016.
75.	Akira Takahashi, Takaharu Kudoh, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : 硬口蓋を基準とした後上歯槽動脈の走行に関する検討, 第70回NPO法人日本口腔科学会学術集会, Apr. 2016.
76.	Takaharu Kudoh, Tetsuya Tamatani, Kenji Fujisawa, Keiko Kudoh, Natsumi Takamaru, Hirokazu Nagai and Youji Miyamoto : 口腔癌に対する強度変調放射線治療に関する臨床的検討, 第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016.
77.	Kenji Fujisawa, Hirokazu Nagai, Natsumi Takamaru, Go Ohe, 都留寛治, 石川邦夫 and Youji Miyamoto : ゼラチン複合型炭酸アパタイトフォームの物理学的評価, 第37回日本バイオマテリアル学会大会, Nov. 2015.
78.	Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 舌扁桃結石に関するX線診断学的検討, 第63回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2015.
79.	Kenji Fujisawa, Go Ohe, Natsumi Takamaru, Tetsuya Tamatani, Yoshiko Yamamura, Keiko Kudoh, Hirokazu Nagai and Youji Miyamoto : 上顎洞底挙上術を併用したインプラントの予後に関する臨床的検討, 第63回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2015.
80.	Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Hirokazu Nagai and Youji Miyamoto : 口腔扁平上皮癌におけるCD44,ABCG2およびALDH1の発現に関する検討, 第60回公益社団法人日本口腔外科学会総会・学術大会, Oct. 2015.
81.	Hirokazu Nagai, Kenji Fujisawa, Go Ohe, Masako Fujioka-Kobayashi, Natsumi Takamaru, Takaharu Kudoh, Tetsuya Tamatani and Youji Miyamoto : 低結晶性炭酸アパタイトの骨再建への応用第1報イヌ歯槽骨欠損部への移植, 第60回公益社団法人日本口腔外科学会総会・学術大会, Oct. 2015.
82.	Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 静脈性血管奇形に対するNd:YAGレーザーを用いた光凝固療法, 第60回公益社団法人日本口腔外科学会総会・学術大会, Oct. 2015.
83.	Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Hirokazu Nagai and Youji Miyamoto : 口腔癌におけるBmi-1とCD24発現の臨床病理病理学的意義, 第74回日本癌学会学術総会, Oct. 2015.
84.	Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Keiko Kudoh, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 口蓋扁桃結石に関するX線診断学的検討 -パノラマX線写真における描出状況, 第69回日本口腔科学会学術集会, May 2015.
85.	鎌田久美子, Nobuyuki Kuribayashi, Natsumi Takamaru, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : 超選択的動注化学療法が奏功した頸部リンパ節転移を伴った下顎歯肉癌の1例, 第44回(公社)日本口腔外科学会中国四国支部学術集会, Apr. 2015.
86.	Keiko Kudoh, Tetsuya Tamatani, Natsumi Takamaru, 木内誠, Kumiko Kamada, Hirokazu Nagai, Kazumi Takaishi and Youji Miyamoto : 水酸化カルシウム系根管充填材料の根尖外溢出により下歯槽神経麻痺が生じた1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2014.
87.	Keiko Kudoh, Tetsuya Tamatani, Natsumi Takamaru, 木内誠, 鎌田久美子, Hirokazu Nagai, Kazumi Takaishi and Youji Miyamoto : 水酸化カルシウム系根管充填材料の根尖外溢出により下歯槽神経麻痺が生じた1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2014.
88.	Tetsuya Tamatani, Natsumi Takamaru, 木内誠, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai and Youji Miyamoto : 口腔癌におけるABCG2とALDH1A1発現の臨床病理学的意義, 第73回日本癌学会学術総会, Sep. 2014.
89.	Takaharu Kudoh, Kenji Fujisawa, Keiko Kudoh, Masako Fujioka-Kobayashi, Nobuyuki Kuribayashi, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Akira Takahashi, Tetsuya Tamatani, Hirokazu Nagai, Hitoshi Ikushima and Youji Miyamoto : 当科における強度変調放射線治療(IMRT)の経験, 第12回中国四国口腔癌研究会学術講演会, Nov. 2013.
90.	Keiji Murakami, Tsuneko Ono, Natsumi Takamaru, Katsuhiko Hirota and Yoichiro Miyake : 緑膿菌臨床分離株による抗菌薬抵抗性と病原因子との関連について, 第61回日本化学療法学会西日本支部総会, Nov. 2013.
91.	Tetsuya Tamatani, Natsumi Takamaru, Masako Fujioka-Kobayashi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 当科を受診した悪性リンパ腫の臨床的検討, 第58回(公社)日本口腔外科学会総会・学術大会, Oct. 2013.
92.	Natsumi Takamaru, 鎌田久美子, Hirokazu Nagai and Youji Miyamoto : 舌から喉頭蓋前間隙へ移動した迷入魚骨の1例, 第58回(公社)日本口腔外科学会総会・学術大会, Oct. 2013.
93.	Tetsuya Tamatani, Natsumi Takamaru, 木内誠, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai and Youji Miyamoto : The clinicopathological role of the nuclear expression of nuclear factor-B in human oral squamous cell carcinoma, 第72回日本癌学会学術大会総会, Oct. 2013.
94.	Masako Fujioka-Kobayashi, Nobuyuki Kuribayashi, Natsumi Takamaru, Keiko Kudoh, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 当科における過去8年間の下顎関節突起骨折の臨床的検討, 第15回口腔顎顔面外傷学会学術大会, Jul. 2013.
95.	Natsumi Takamaru, Hirokazu Nagai, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : 当科におけるビスフォスフォネート関連顎骨壊死(BRONJ)患者の臨床的検討, 第67回NPO法人日本口腔科学会学術集会, Jun. 2013.
96.	Natsumi Takamaru, Hirokazu Nagai, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : 当科におけるビスフォスフォネート関連顎骨壊死(BRONJ)患者の臨床的検討, 第67回NPO法人日本口腔科学会学術集会, May 2013.
97.	鎌田久美子, Keiko Kudoh, Masako Fujioka-Kobayashi, Nobuyuki Kuribayashi, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai, 安田勝裕, 横山正秋 and Youji Miyamoto : 徳島県における口腔がん検診と口腔がん啓発のための活動状況, 第42回(公社)日本口腔外科学会中四国支部学術集会, Apr. 2013.
98.	Masako Fujioka-Kobayashi, Natsumi Takamaru, Tetsuya Tamatani, Daisuke Uchida, Go Ohe, Hirokazu Nagai and Youji Miyamoto : ナビゲーションシステムを用いて腫瘍切除を行い，腸骨移植とインプラントで再建した骨形成線維腫の1例, 第42回(公社)日本口腔外科学会中四国支部学術集会, Apr. 2013.
99.	Keiji Murakami, Tsuneko Ono, Natsumi Takamaru, Katsuhiko Hirota and Yoichiro Miyake : 緑膿菌における付着及びバイオフィルム形成菌の抗菌薬抵抗性遺伝子のスクリーニング, 第60回日本化学療法学会西日本支部総会, Nov. 2012.
100.	Hirokazu Nagai, Kenji Fujisawa, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Go Ohe, Naozumi Ishimaru and Youji Miyamoto : 頬部に生じた粘液種の1例, 第57回公益社団法人日本口腔外科学会, Oct. 2012.
101.	Tetsuya Tamatani, Natsumi Takamaru, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai and Youji Miyamoto : 口腔扁平上皮癌におけるXIAPの発現に関する検討, 第57回公益社団法人日本口腔外科学会, Oct. 2012.
102.	鈴木悠, Go Ohe, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 抜歯後疼痛を対象としたセレコキシブの有効性および安全性の検討, 第60回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2012.
103.	Natsumi Takamaru, 鎌田久美子, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 口腔癌術後補助化学療法としてのS-1の短期成績, 第66回日本口腔科学会学術集会, May 2012.
104.	Go Ohe, 小出真理子, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 下顎枝垂直骨切り術のためのCTを用いた下顎枝形態の検討, 第66回日本口腔科学会学術集会, May 2012.
105.	原香苗, Hirokazu Nagai, Nobuyuki Kuribayashi, Takeshi Yamamoto, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : 当科における悪性リンパ腫の臨床的検討, 第41回(社)日本口腔外科学会中・四国地方会, Apr. 2012.
106.	佐藤裕子, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 当科におけるビスフォスフォネート関連顎骨壊死(BRONJ)患者の臨床的検討, 第41回(社)日本口腔外科学会中・四国地方会, Apr. 2012.
107.	Kenji Fujisawa, Go Ohe, Daisuke Uchida, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : ショートインプラントの生存率に関する臨床的検討, 第15回日本学顔面インプラント学会, Dec. 2011.
108.	Makoto Kinouchi, Kenji Fujisawa, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Hirokazu Nagai, Shinji Fujihara, Eiji Tanaka and Youji Miyamoto : 下顎枝矢状分割骨切り術と下顎枝垂直骨切り術の術後安定性に関する検討, 第59回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2011.
109.	小出真理子, Go Ohe, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 術前CTを用いた下顎枝の形態学的検討, 第59回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2011.
110.	鎌田久美子, Natsumi Takamaru, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : S-1による術後補助化学療法に関する検討, 第10回中四国口腔癌研究会学術講演会, Oct. 2011.
111.	Natsumi Takamaru, Hirokazu Nagai, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Naozumi Ishimaru and Youji Miyamoto : 下顎骨に発生した歯原性粘液腫の1例, 第 56回日本口腔外科学会総会・学術大会, Oct. 2011.
112.	佐藤裕子, Miwa Miyauchi, Daisuke Uchida, Natsumi Takamaru, Tetsuya Tamatani, Kenji Fujisawa, Hirokazu Nagai, Michiko Kubo, Chieko Sugawara, Akira Takahashi and Youji Miyamoto : 口腔扁平上皮癌の頸部リンパ節転移の診断におけるFDG-PET検査の有用性, 第40回(社)日本口腔外科学会中・四国地方会, May 2011.
113.	Kenji Fujisawa, Natsumi Takamaru, Keiko Kudoh, Go Ohe, Daisuke Uchida, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : インプラント治療に関連したと思われるビスフォスフォネート製剤による顎骨壊死の2例, Japanese Journal of Maxillo Facial Implants, Vol.9, No.3, 86, Sep. 2010.
114.	Natsumi Takamaru, Tetsuya Tamatani, Daisuke Uchida, Shinya Horiuchi, Hirokazu Nagai, Eiji Tanaka and Youji Miyamoto : 最近，頭を悩ませた臨床症例その5∼片側性下顎頭過成長を伴う顔面非対称症例の治療経験, 四国歯学会第36回例会, Mar. 2010.
115.	Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : 下顎頭の片側性過成長による顔面非対称症例の治療経験, Japanese Journal of Oral & Maxillofacial Surgery, Vol.56, No.Suppl., 151, 2010.
116.	Natsumi Takamaru, Tetsuya Tamatani, Daisuke Uchida, Shinya Horiuchi, Hirokazu Nagai, Eiji Tanaka and Youji Miyamoto : 最近，頭を悩ませた臨床症例(その5) 片側性下顎頭過成長を伴う顔面非対称症例の治療経験, Shikoku Dental Research, Vol.23, No.2, 142, 2010.
117.	Tetsuya Tamatani, Natsumi Takamaru, Daisuke Uchida, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : 口腔扁平上皮癌におけるsurvivinの発現に関する検討, The Japanese Journal of Tissue Culture Society for Dental Research, Vol.20, No.1, 59-60, 2010.

Et cetera, Workshop:

1.	尾上真奈美, Kazumi Takaishi, Keiko Kudoh, Natsumi Takamaru, 鎌田久美子, 大塚良, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Youji Miyamoto and Hiroshi Kitahata : 根管治療後に下歯槽神経感覚障害が生じた1例, 第32回中国·四国歯科麻酔研究会, Jul. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

骨補填材兼GBR用スペーサー機能をもつ炭酸アパタイト／魚コラーゲンシートの開発 (Project/Area Number: 23K09372 )
感染制御と骨再生を同時に可能とするハイブリッド型骨補填材による顎骨骨髄炎治療戦略 (Project/Area Number: 21K10095 )
3種類のサンプリングによるアレイ解析を用いた口腔癌のセツキシマブ耐性化機構の解明 (Project/Area Number: 18K09792 )
Elucidation of the expression and regulation mechanisms of Lubricin aiming at the development of a new treatment for osteoarthritis of the jaw (Project/Area Number: 18K09769 )
Identification of Metastasis-specific miRNAs and Establishment of Diagnostic Methods Focusing on Cancer Stem Cells and Blood of Patients with Oral Cancer Metastasis (Project/Area Number: 18K09745 )
Development of the bone regenerative medicine with the porous carbonate apatite made from calcium sulfate and bone marrow stem cell (Project/Area Number: 16K11752 )
The inducing differentiation of iPS cells and salivary gland regeneration that reproduces the epithelial-mesenchymal interaction in initiation stage (Project/Area Number: 16K11751 )
We investigate the essence of osseointegration and biointegration in the cell (Project/Area Number: 15K15741 )
the examination of microRNA related with lymph node metastasis (Project/Area Number: 15K11294 )
Novel immunotherapy with HDAC inhibitor and OK-432 targeting PD-1 (Project/Area Number: 15K11293 )
Challenge of leptin as new healing accelerant for wound healing and intractable stomatitis (Project/Area Number: 15K11253 )
Development of the anticancer drug sensitivity testing and elucidation of the resistance mechanism for oral cancer using new cultural method CTOS (Project/Area Number: 25463110 )
Development of combination therapy, targeting NF-kB and CXCR4-related miRNA in oral cancer (Project/Area Number: 25293411 )
Development of novel molecular therapy target at epigenetics against salivary gland cancer (Project/Area Number: 24593035 )
Analysis of the establishment and the resistance mechanism of the Docetaxel-resistant oral squamous cell carcinoma (Project/Area Number: 23792351 )
Development of combined therapy of oral cancer of which molecular target survivin and NF-・B (Project/Area Number: 21792006 )
Search by Researcher Number (40513031)

Associate Professor : Takamaru, Natsumi

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)