Tokushima University / Educator and Researcher Directory --- Kitamura, Takamasa

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1.	Anrizandy Narwidina, Aya Miyazaki, Kokoro Iwata, Rika Kurogoushi, Asuna Sugimoto, Yasusei Kudo, Keita Kawarabayashi, Yoshihito Yamakawa, Yuki Akazawa, Takamasa Kitamura, Hiroshi Nakagawa, Kimiko Ueda Yamaguchi, Tomokazu Hasegawa, Keigo Yoshizaki, Satoshi Fukumoto, Akihito Yamamoto, Naozumi Ishimaru, Tomonori Iwasaki and Tsutomu Iwamoto : Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression., Biochemical and Biophysical Research Communications, Vol.650, 47-54, 2023. (Summary) Iroquois homeobox (Irx) genes are TALE-class homeobox genes that are evolutionarily conserved across species and have multiple critical cellular functions in fundamental tissue development processes. Previous studies have shown that Irxs genes are expressed during tooth development. However, the precise roles of genes in teeth remain unclear. Here, we demonstrated for the first time that Irx3 is an essential molecule for the proliferation and differentiation of odontoblasts. Using cDNA synthesized from postnatal day 1 (P1) tooth germs, we examined the expression of all Irx genes (Irx1-Irx6) by RT-PCR and found that all genes except Irx4 were expressed in the tooth tissue. Irx1-Irx3 a were expressed in the dental epithelial cell line M3H1 cells, while Irx3 and Irx5 were expressed in the dental mesenchymal cell line mDP cells. Only Irx3 was expressed in both undifferentiated cell lines. Immunostaining also revealed the presence of IRX3 in the dental epithelial cells and mesenchymal condensation. Inhibition of endogenous Irx3 by siRNA blocks the proliferation and differentiation of mDP cells. Wnt3a, Wnt5a, and Bmp4 are factors involved in odontoblast differentiation and were highly expressed in mDP cells by quantitative PCR analysis. Interestingly, the expression of Wnt5a (but not Wnt3a or Bmp4) was suppressed by Irx3 siRNA. These results suggest that Irx3 plays an essential role in part through the regulation of Wnt5a expression during odontoblast proliferation and differentiation. (Keyword) Homeodomain Proteins / Transcription Factors / Odontoblasts / Genes, Homeobox / cell differentiation / cell proliferation and differentiation (Tokushima University Institutional Repository) ● Metadata: 118052 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbrc.2023.02.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36773339 ● Search Scopus @ Elsevier (PMID): 36773339 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2023.02.004 (Tokushima University Institutional Repository: 118052, DOI: 10.1016/j.bbrc.2023.02.004, PubMed: 36773339)
2.	Rika Kurogoushi, Kokoro Iwata, Hiroshi Nakagawa, Tomokazu Hasegawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Yuki Akazawa, Asuna Sugimoto, Keita Kawarabayashi, Aya Miyazaki, Rie Niji, 藤島史帆, Tomonori Iwasaki and Tsutomu Iwamoto : 当科における5年間の障害児・有病児の初診時実態調査, The Japanese Journal of Pediatric Dentistry, Vol.60, No.1, 20-27, 2022. (Summary) 障害児や有病児への理解の深まりから社会環境や福祉制度の整備が進みつつあるが，障害や全身疾患をもつ児が地域において疾病予防も含めた歯科医療を受けられる環境がいまだ十分にあるとは言えず，実情に応じた環境整備が求められる．そこで，今回，平成25年度から平成29年度に当科を受診した児のうち障害児・有病児の5年間の初診時実態調査を行い，過去に当科で行った調査と比較し，近年の変化を検討した．初診患者1,301名のうち，障害児・有病児の割合は49 (Keyword) う蝕先天奇形口蓋裂口唇裂障害者歯科医療発達障害染色体異常小児歯科医療慢性疾患患者歯科医療病院歯科診療部門紹介と相談年齢因子徳島県実態調査地域差ヒト小児(6∼12) 男女歯学
3.	Rika Kurogoushi, Tomokazu Hasegawa, Yuki Akazawa, Kokoro Iwata, Asuna Sugimoto, Kimiko Ueda Yamaguchi, Aya Miyazaki, Anrizandy Narwidina, Keita Kawarabayashi, Takamasa Kitamura, Hiroshi Nakagawa, Tomonori Iwasaki and Tsutomu Iwamoto : Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells, Experimental and Therapeutic Medicine, Vol.22, No.6, 1356, 2021. (Summary) The regulation of the mesenchymal stem cell (MSC) programming mechanism promises great success in regenerative medicine. Tissue regeneration has been associated not only with the differentiation of MSCs, but also with the microenvironment of the stem cell niche that involves various cytokines and immune cells in the tissue regeneration site. In the present study, fibroblast growth factor 2 (FGF2), the principal growth factor for tooth development, dental pulp homeostasis and dentin repair, was reported to affect the expression of cytokines in human dental pulp-derived MSCs. FGF2 significantly inhibited the expression of chemokine C-C motif ligand 11 (CCL11) in a time- and dose-dependent manner in the SDP11 human dental pulp-derived MSC line. This inhibition was diminished following treatment with the AZD4547 FGF receptor (FGFR) inhibitor, indicating that FGF2 negatively regulated the expression of CCL11 in SDP11 cells. Furthermore, FGF2 activated the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNK) in SDP11 cells. The mechanism of the FGFR-downstream signaling pathway was then studied using the SB203580, U0126 and SP600125 inhibitors for p38 MAPK, ERK1/2, and JNK, respectively. Interestingly, only treatment with SP600125 blocked the FGF2-mediated suppression of CCL11. The present results suggested that FGF2 regulated the expression of cytokines and suppressed the expression of CCL11 via the JNK signaling pathway in human dental pulp-derived MSCs. The present findings could provide important insights into the association of FGF2 and CCL11 in dental tissue regeneration therapy. (Tokushima University Institutional Repository) ● Metadata: 117039 (Link to Publication Site) ● Publication site (DOI): 10.3892/etm.2021.10791 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34659502 ● Search Scopus @ Elsevier (PMID): 34659502 ● Search Scopus @ Elsevier (DOI): 10.3892/etm.2021.10791 (Tokushima University Institutional Repository: 117039, DOI: 10.3892/etm.2021.10791, PubMed: 34659502)
4.	船山ひろみ, 齊藤桂子, 森川和政, 仲野和彦, 飯沼光生, 清水武彦, 下村淳子[黒木], 馬場篤子, 内川喜盛, 島田幸恵, 齊藤正人, 倉重圭史, 福田敦史, 八若保孝, 島村和宏, 早崎治明, 大島邦子, 関本恒夫, 大須賀直人, 星野倫範, 新谷誠康, 辻野啓一郎, 苅部洋行, Tetsuo Shirakawa, Tsutomu Iwamoto, 宮新美智世, 船津敬弘, 木本茂成, 浅里仁, 守安克也, 長谷川信乃, 大川玲奈, 有田憲司, 原田京子, 香西克之, 岩本優子, 仲野道代, 平野慶子, Takamasa Kitamura, 牧憲司, 山座治義, 尾崎正雄, 藤原卓, 山崎要一, 村上大輔 and 朝田芳信 : A Questionnaire Survey on the Guideline for Pediatric Dentistry in the National Dentistry Examination, The Japanese Journal of Pediatric Dentistry, Vol.59, No.2, 80-94, 2021. (Keyword) 歯科医師国家試験 / 出題基準 / アンケート調査 / National Dentistry Examination / Guideline / Questionnaire Survey (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.59.2_80 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390855511130808192 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.59.2_80 (DOI: 10.11411/jspd.59.2_80, CiNii: 1390855511130808192)
5.	岩田こころ, Rika Kurogoushi, Asuna Sugimoto, 藤島史帆, Yuki Akazawa, Keita Kawarabayashi, Aya Miyazaki, Takamasa Kitamura, Rie Niji, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto : Survey of the Actual State of New Patients at the Pediatric Dentistry Department of Tokushima University Hospital between 1989 and 2018, The Japanese Journal of Pediatric Dentistry, Vol.59, No.1, 8-13, 2021. (Summary) <p>The Heisei Era ended at the end of April 2019 and the Reiwa Era began.</p><p>For about 30 years in the Heisei era after the Showa era, the environment surrounding children changed rapidly, including the economic downturn, the acceleration of late marriage and declining birthrate, and progress in information and communication technology. As a result, individual households have diversified and a large polarization has become apparent. As pediatric dentists, we need to deal with and support children with all kinds of problems. Therefore, to clarify the transition of the first-visit patients in our clinic, we categorized the 30 years from 1989 to 2018 by five-year groups: early (1989-1993), middle (1997-2001) and late (2013-2018) stages, with a total of 5,892 patients, and then investigated and analyzed their properties. As a result, the number of new patients decreased from 2,477 in the early stage to 1,301 in the late stage. The male-female ratio was approximately 1:1 in each period. As for age, school age was the highest at about 40%, and there was no significant change in the age composition in each period. The most common chief complaint during each period was tooth decay, but it decreased from 44% in the early stage to 27% in the late stage. The proportion of children who brought a letter of referral increased from 23% in the early stage to 83% in the late stage, and the proportion of children with disabilities and illness increased from 13.8% in the early stage to 33% in the late stage. Compared to the early days, the chief complaints have diversified, and it has become clear that the functional differentiation of general dental clinics and university hospitals is progressing. Furthermore, it was suggested that the importance of medical and dental cooperation will increase in the future.</p> (Keyword) 実態調査 / 初診患者 / 平成 / 小児歯科 / Survey of actual state / New patients / Heisei / Pediatric dentistry (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.59.1_8 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390854139452228096 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.59.1_8 (DOI: 10.11411/jspd.59.1_8, CiNii: 1390854139452228096)
6.	Aya Miyazaki, Asuna Sugimoto, Keigo Yoshizaki, Keita Kawarabayashi, Kokoro Iwata, Rika Kurogohshi, Takamasa Kitamura, Kunihiro Otsuka, Tomokazu Hasegawa, Yuki Akazawa, Satoshi Fukumoto, Naozumi Ishimaru and Tsutomu Iwamoto : Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1, Scientific Reports, Vol.9, No.1, 14762, 2019. (Summary) Signal transmission from the mechanical forces to the various intracellular activities is a fundamental process during tissue development. Despite their critical role, the mechanism of mechanical forces in the biological process is poorly understood. In this study, we demonstrated that in the response to hydrostatic pressure (HP), the piezo type mechanosensitive ion channel component 1 (PIEZO1) is a primary mechanosensing receptor for odontoblast differentiation through coordination of the WNT expression and ciliogenesis. In stem cells from human exfoliated deciduous teeth (SHED), HP significantly promoted calcium deposition as well as the expression of odontogenic marker genes, PANX3 and DSPP, and WNT related-genes including WNT5b and WNT16, whereas HP inhibited cell proliferation and enhanced primary cilia expression. WNT signaling inhibitor XAV939 and primary cilia inhibitor chloral hydrate blocked the HP-induced calcium deposition. The PIEZO1 activator Yoda1 inhibited cell proliferation but induced ciliogenesis and WNT16 expression. Interestingly, HP and Yoda1 promoted nuclear translocation of RUNX2, whereas siRNA-mediated silencing of PIEZO1 decreased HP-induced nuclear translocation of RUNX2. Taken together, these results suggest that PIEZO1 functions as a mechanotransducer that connects HP signal to the intracellular signalings during odontoblast differentiation. (Tokushima University Institutional Repository) ● Metadata: 114667 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-019-51381-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31611621 ● Search Scopus @ Elsevier (PMID): 31611621 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-51381-9 (Tokushima University Institutional Repository: 114667, DOI: 10.1038/s41598-019-51381-9, PubMed: 31611621)
7.	Kimiko Ueda Yamaguchi, Yuki Akazawa, Kawarabayashi Keita, Asuna Sugimoto, Hiroshi Nakagawa, miyazaki aya, Weih Falk, Kurogoushi Rika, Iwata Kokoro, Takamasa Kitamura, Yamada Aya, Tomokazu Hasegawa, Fukumoto Satoshi and Tsutomu Iwamoto : Combination of ions promotes cell migration via extracellular signalregulated kinase 1/2 signaling pathway in human gingival fibroblasts., Molecular Medicine Reports, Vol.19, No.6, 5039-5045, 2019. (Summary) Wound healing is a dynamic process that involves highly coordinated cellular events, including proliferation and migration. Oral gingival fibroblasts serve a central role in maintaining oral mucosa homeostasis, and their functions include the coordination of physiological tissue repair. Recently, surface pre-reacted glass-ionomer (S-PRG) fillers have been widely applied in the field of dental materials for the prevention of dental caries, due to an excellent ability to release fluoride (F). In addition to F, S-PRG fillers are known to release several types of ions, including aluminum (Al), boron (B), sodium (Na), silicon (Si) and strontium (Sr). However, the influence of these ions on gingival fibroblasts remains unknown. The aim of the present study was to examine the effect of various concentrations of an S-PRG filler eluate on the growth and migration of gingival fibroblasts. The human gingival fibroblast cell line HGF-1 was treated with various dilutions of an eluent solution of S-PRG, which contained 32.0 ppm Al, 1,488.6 ppm B, 505.0 ppm Na, 12.9 ppm Si, 156.5 ppm Sr and 136.5 ppm F. Treatment with eluate at a dilution of 1:10,000 was observed to significantly promote the migration of HGF-1 cells. In addition, the current study evaluated the mechanism underlying the mediated cell migration by the S-PRG solution and revealed that it activated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not of p38. Furthermore, treatment with a MEK inhibitor blocked the cell migration induced by the solution. Taken together, these results suggest that S-PRG fillers can stimulate HGF-1 cell migration via the ERK1/2 signaling pathway, indicating that a dental material containing this type of filler is useful for oral mucosa homeostasis and wound healing. (Tokushima University Institutional Repository) ● Metadata: 113289 (Link to Publication Site) ● Publication site (DOI): 10.3892/mmr.2019.10141 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31059063 ● Summary page in Scopus @ Elsevier: 2-s2.0-85066160258 (Tokushima University Institutional Repository: 113289, DOI: 10.3892/mmr.2019.10141, PubMed: 31059063, Elsevier: Scopus)
8.	Takamasa Kitamura, Asuna Sugimoto, Keita Kawarabayashi and Tsutomu Iwamoto : Additional Maxillary Primary Central Incisor Root Causing Disturbance of Permanent Tooth Eruption:Case Report, The Japanese Journal of Pediatric Dentistry, Vol.56, No.1, 81-86, 2018. (Summary) <p>Teeth with a supernumerary root, such as a double, additional, extra, or accessory root, or multiple roots, are a deviation from the general form. A supernumerary root can occur in nearly all types of permanent teeth, while it is extremely rare in deciduous teeth. In Japan, there are only a few clinical reports of such an occurrence in maxillary and mandible primary canines, or maxillary second and mandibular primary molars, while clinical reports of a maxillary primary central incisor with a supernumerary root are available. Here, we report a case of a maxillary primary central incisor with an additional root that caused disturbance of permanent tooth eruption.</p><p></p> (Keyword) Maxillary primary central incisor / Additional root / Supernumerary root / Delayed eruption / Case report (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.56.1_81 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390564238077375616 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.56.1_81 (DOI: 10.11411/jspd.56.1_81, CiNii: 1390564238077375616)
9.	Keita Kawarabayashi, Asuna Sugimoto, Yuki Akazawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Aya Miyazaki and Tsutomu Iwamoto : Association Between Dental Caries and Lifestyle in Children, The Japanese Journal of Pediatric Dentistry, Vol.56, No.1, 26-32, 2018. (Summary) <p>The prevalence of dental caries is low in younger children, while rapid progression occurs in adolescence. The purpose of this study was to clarify the association of prevalence of dental caries in children and daily lifestyle habits. A total of 100 children (57 boys, 43 girls, average age 4 years 6 months) who visited our department were enrolled and divided into the caries and non-caries group. Each parent or guardian was asked regarding the daily lifestyle of the child, including nutrition and oral health. We found that "maternal employment", "bedtime", and "frequent snacks" were correlated with dental caries prevalence. There was no significant differences in regard to "living with grandparents","presence of brothers and/or sisters", "wake-up time", and "knowledge of dental health". Furthermore, we found that all children with caries ate excessively during meals, excluding snacks. Dental health promotion contributes to specifically target dental caries, while establishment of healthy lifestyle habits in children, particularly healthy habits for eating, is important.</p><p></p> (Keyword) 齲蝕罹患，生活習慣，自律支援 (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.56.1_26 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845713054285568 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.56.1_26 (DOI: 10.11411/jspd.56.1_26, CiNii: 1390845713054285568)
10.	Asuna Sugimoto, Yuki Akazawa, Keita Kawarabayashi, Aya Miyazaki, Kimiko Ueda Yamaguchi, Takamasa Kitamura and Tsutomu Iwamoto : A study on the effect of Oral Myofunctional Therapy (MFT) in children, The Japanese Journal of Pediatric Dentistry, Vol.56, No.1, 1-11, 2018. (Summary) <p>Oral myofunctional therapy (MFT) is a specialized training technique taught to patients for selftreatment of a variety of oral muscle functional disorders and habit patterns that disrupt normal oral and dental development. Although various training methods have been proposed, there are few reports on the effects of training in individual subjects. The purpose of this study was to clarify the effects of various MFT methods in 20 children (15 boys, 5 girls : average age 7 years 7 months) who underwent training at our hospital. The results revealed that the percentage of children with poor lip seal improved from 55% to 33%,while tongue thrust during swallowing and articulating improved from 100% to 50% and 95% to 60% respectively. We also found that "Water Slurp Swallow" training significantly contributed to improved tongue thrust during swallowing. However, even though the subjects were able to master the training methods, they failed to obtain correct oral functions, thus new training methods as well as the timing for starting training must be considered. Oral function is regarded as important throughout life, with childhood a crucial stage for establishing a healthy foundation. Our results also showed that 20% of the child subjects had oral functional difficulties without morphological problems, indicating that both morphological and functional problems should be evaluated. MFT is an effective method for support of oral function and development.</p><p></p> (Keyword) 口腔筋機能療法 / MFT / infant (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.56.1_1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390564238077774720 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.56.1_1 (DOI: 10.11411/jspd.56.1_1, CiNii: 1390564238077774720)
11.	Asuna Sugimoto, Aya Miyazaki, Keita Kawarabayashi, Masayuki Shono, Yuki Akazawa, Tomokazu Hasegawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Yoshizaki keigo, Fukumoto Satoshi and Tsutomu Iwamoto : Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells, Scientific Reports, Vol.7, No.1, 17696, 2017. (Summary) The extracellular environment regulates the dynamic behaviors of cells. However, the effects of hydrostatic pressure (HP) on cell fate determination of mesenchymal stem cells (MSCs) are not clearly understood. Here, we established a cell culture chamber to control HP. Using this system, we found that the promotion of osteogenic differentiation by HP is depend on bone morphogenetic protein 2 (BMP2) expression regulated by Piezo type mechanosensitive ion channel component 1 (PIEZO1) in MSCs. The PIEZO1 was expressed and induced after HP loading in primary MSCs and MSC lines, UE7T-13 and SDP11. HP and Yoda1, an activator of PIEZO1, promoted BMP2 expression and osteoblast differentiation, whereas inhibits adipocyte differentiation. Conversely, PIEZO1 inhibition reduced osteoblast differentiation and BMP2 expression. Furthermore, Blocking of BMP2 function by noggin inhibits HP induced osteogenic maker genes expression. In addition, in an in vivo model of medaka with HP loading, HP promoted caudal fin ray development whereas inhibition of piezo1 using GsMTx4 suppressed its development. Thus, our results suggested that PIEZO1 is responsible for HP and could functions as a factor for cell fate determination of MSCs by regulating BMP2 expression. (Tokushima University Institutional Repository) ● Metadata: 112396 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-017-18089-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29255201 ● Summary page in Scopus @ Elsevier: 2-s2.0-85038567061 (Tokushima University Institutional Repository: 112396, DOI: 10.1038/s41598-017-18089-0, PubMed: 29255201, Elsevier: Scopus)
12.	Aimi Yamamoto, Hiroshi Nakagawa, Yukiko Kori, Takamasa Kitamura, Asuna Sugimoto and Tsutomu Iwamoto : Disaster Prevention for Children and Adults with Disabilities, The Japanese Journal of Pediatric Dentistry, Vol.53, No.3, 373-382, 2015. (Keyword) 災害医療 / 災害時要援護者 / 歯科医療支援 / 防災意識 (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.53.3_373 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205519929088 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.53.3_373 (DOI: 10.11411/jspd.53.3_373, CiNii: 1390001205519929088)
13.	Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Kimiko Ueda Yamaguchi, Asuna Sugimoto, Takamasa Kitamura, Hiroshi Nakagawa, Akira Ishisaki and Tsutomu Iwamoto : Recruitment of mesenchymal stem cells by stromal cell-derived factor 1 in pulp cells from deciduous teeth, International Journal of Molecular Medicine, Vol.36, 442-448, 2015. (Summary) Dental pulp cells (DPCs), including dental pulp (DP) stem cells, play a role in dentine repair under certain conditions caused by bacterial infections associated with caries, tooth fracture and injury. Mesenchymal stem cells (MSCs) have also been shown to be involved in this process of repair. However, the mechanisms through which MSCs are recruited to the DP have not yet been elucidated. Therefore, the aim of the present in vitro study was to investigate whether stromal cell-derived factor 1 (SDF1)-C-X-C chemokine receptor type 4 (CXCR4) signaling is involved in tissue repair in the DP of deciduous teeth. A single-cell clone from DPCs (SDP11) and UE7T-13 cells were used as pulp cells and MSCs, respectively. The MG-63 and HuO9 cells, two osteosarcoma cell lines, were used as positive control cells. Reverse transcription polymerase chain reaction (RT-PCR) revealed that all cell lines (SDP11, UE7T-13 MG-63 and HuO9) were positive for both SDF1 and CXCR4 mRNA expression. Moreover, immunocytochemical analysis indicated that SDF1 and CXCR4 proteins were expressed in the SDP11 and UE7T-13 cells. SDF1 was also detected in the cell lysates (CLs) and conditioned medium (CM) collected from the SDP11 and UE7T-13 cells, and AMD3100, a specific antagonist of CXCR4, inhibited the migration of the UE7T-13 cells; this migration was induced by treatment with CM, which was collected from the SDP11 cells. In addition, real-time PCR showed that the expression of SDF1 in the SDP11 cells was inhibited by treatment with 20 ng/ml fibroblast growth factor (FGF)-2, and exposure to AZD4547, an inhibitor of the FGF receptor, blocked this inhibition. Collectively, these data suggest that SDF1 produced by DP plays an important role in homeostasis, repair and regeneration via the recruitment of MSCs. (Link to Publication Site) ● Publication site (DOI): 10.3892/ijmm.2015.2247 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26082290 ● Summary page in Scopus @ Elsevier: 2-s2.0-84934271560 (DOI: 10.3892/ijmm.2015.2247, PubMed: 26082290, Elsevier: Scopus)
14.	Tomokazu Hasegawa, Yuki Akazawa, Takamasa Kitamura, Asuna Sugimoto, Kimiko Ueda Yamaguchi and Tsutomu Iwamoto : Dental findings and management in a child with hypomelanosis of Ito, Pediatric Dental Journal, Vol.24, No.3, 173-177, 2014. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.pdj.2014.08.002 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84938485288 (DOI: 10.1016/j.pdj.2014.08.002, Elsevier: Scopus)
15.	Tomokazu Hasegawa, Yuki Akazawa, Hirokazu Nagai, Takamasa Kitamura, Naozumi Ishimaru, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Yukiko Kori, Aimi Yamamoto and Tsutomu Iwamoto : Capillary Hemangioma on Palate of Infant:Case Report, The Japanese Journal of Pediatric Dentistry, Vol.52, No.3, 448-453, 2014. (Summary) A hemangioma frequently occurs on the tongue, lip, buccal mucosa, and gingiva in the oral region,though it relatively rarely seen on the palate. We report a case of capillary hemangioma found on the palate of a 2-year-10-month-old boy. He was referred to our department with the chief complaint of a tumor on the palate and a hemangioma was noted on the palatal side of the upper deciduous incisors.We performed surgical resection and the mass was extirpated. The postoperative course was uneventful. Although there was no evidence of recurrence at 6 months after surgery, careful follow-up examinations will be necessary until the upper permanent incisors erupt. (Keyword) 血管腫 / 口蓋 / 幼児期 (Link to Publication Site) ● Publication site (DOI): 10.11411/jspd.52.3_448 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680495239168 ● Search Scopus @ Elsevier (DOI): 10.11411/jspd.52.3_448 (DOI: 10.11411/jspd.52.3_448, CiNii: 1390282680495239168)
16.	Yuki Akazawa, Takamasa Kitamura, Yuri Fujihara, Yoshitaka Yoshimura, Masato Mitome and Tomokazu Hasegawa : Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus., International Journal of Molecular Medicine, Vol.31, No.2, 307-314, 2012. (Summary) In this study, we examined the effect of forced mastication on neurogenesis in the hippocampal dentate gyrus (DG) of adult mice. Six-week-old mice were subjected to either a hard or normal diet for 13 weeks. They received a daily injection of bromodeoxyuridine (BrdU) for 12 consecutive days beginning at 14 weeks of age. The number of BrdU-positive cells in the DG was counted 1 day after and 5 weeks after the final BrdU injection. The number of BrdU-positive cells 1 day after injection did not differ between the 2 diet groups. However, the number of BrdU-positive cells in the group fed the hard diet was significantly increased 5 weeks after BrdU injection compared to the group fed the normal diet. The results of the Morris water maze test showed that mice fed a hard diet required significantly less time to reach the platform than the control mice when tested at 10 days. Moreover, mice in the group fed the hard diet spent significantly more time in the former platform area than the group fed the normal diet, indicating that hard diet feeding improved spatial memory compared to normal diet feeding. Real-time PCR analysis showed that the expression of glutamate receptor 1 mRNA was significantly increased in the group fed the hard diet compared with the group fed the normal diet. These results suggest that mastication increases the survival of adult neural stem cells in the hippocampal DG. (Keyword) Adult Stem Cells / Animals / Cell Proliferation / Cell Survival / Dentate Gyrus / Diet / Eating / Gene Expression Regulation, Developmental / Intercellular Signaling Peptides and Proteins / Mastication / Mice / Mice, Inbred C57BL / Nerve Growth Factors / Neural Stem Cells / Neurogenesis / RNA, Messenger (Link to Publication Site) ● Publication site (DOI): 10.3892/ijmm.2012.1217 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23254518 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873182824 (DOI: 10.3892/ijmm.2012.1217, PubMed: 23254518, Elsevier: Scopus)
17.	Yuri Fujihara, 赤澤友基, Takamasa Kitamura, Tomokazu Hasegawa and Masato Mitome : Many Congenital Missing Teeth in a Case of Bloch-Sulzberger Syndrome, Journal of the Japanese Society for Disability and Oral Health, Vol.33, No.1, 74-79, 2012. (Keyword) Bloch-Sulzberger syndrome / Congenital missing teeth / Infant denture (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573387450569474944 (CiNii: 1573387450569474944)

Review, Commentary:

1.	Kazumi Takaishi, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Ohtuka Ryo, Yuki Akazawa, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Kohichi Kani, Keiko Aota, Yukihiro Momota, Yoshiko Yamamura, Keiko Kudoh, Go Ohe, Tetsuya Tamatani, Youji Miyamoto, Masayuki Azuma, Tsutomu Iwamoto and Hiroshi Kitahata : Dental Treatment under General Anesthesia in Tokushima University Hospital - Safety Management of Disabled Patients with Special Needs during Dental Treatment-, Journal of Oral Health and Biosciences, Vol.31, No.1, 62-67, Jul. 2018. (Summary) We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs. (Keyword) 全身麻酔 / 障害者 / 日帰り全身麻酔 / 歯科治療 (Tokushima University Institutional Repository) ● Metadata: 111940 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.31.1_62 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390845712973457920 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_62 (Tokushima University Institutional Repository: 111940, DOI: 10.20738/johb.31.1_62, CiNii: 1390845712973457920)
2.	Tsutomu Iwamoto, Asuna Sugimoto, Takamasa Kitamura, Yuki Akazawa and Tomokazu Hasegawa : The role of extracellular ATP-mediated purinergic signaling in bone, cartilage, and tooth tissue, Journal of Oral Biosciences, Vol.56, No.4, 131-135, Jul. 2014. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.job.2014.07.003 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84927910794 (DOI: 10.1016/j.job.2014.07.003, Elsevier: Scopus)

Proceeding of Domestic Conference:

1.	Eiji Kondou, Yuki Sakamoto, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, 山崎裕行 (名), Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討, 第47回日本口蓋裂学会, May 2023.
2.	Yuki Sakamoto, Eiji Kondou, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, Hiroyuki Yamasaki, Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討, 第47回日本口蓋裂学会, May 2023.
3.	坂本幸, Eiji Kondou, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, 山崎裕行, Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の新生児聴覚スクリーニング結果と滲出性中耳炎罹患率, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 153, Apr. 2023. (Keyword) 口蓋裂(合併症) 新生児スクリーニング中耳炎-滲出性(診断,合併症) 発生率大学病院聴覚検査ヒト乳児(1∼23ヶ月) 幼児(2∼5) 男女歯学
4.	Eiji Kondou, 坂本幸, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, 山崎裕行, Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 154, Apr. 2023. (Keyword) 口蓋裂(合併症) 中耳炎-滲出性(外科的療法,合併症) *中耳換気大学病院結果再現性ヒト乳児(1∼23ヶ月) 幼児(2∼5) 小児(6∼12) 青年期(13∼18) 男女歯学
5.	和田涼平, Keiichiro Watanabe, Kaoru Yoshinaga, 金秀河, 花輪茂己, 田中茉里子, 坂本幸, Aki Shimada, Eiji Kondou, Takamasa Kitamura, 山崎裕行, Kazuhide Mineda, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における過去10年間の口唇裂・口蓋裂患者に関する臨床統計調査, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 200, Apr. 2023. (Keyword) 口蓋裂口唇裂統計大学病院ヒト男女歯学
6.	Kimiko Ueda Yamaguchi, Yuki Akazawa, Keita Kawarabayashi, Aya Miyazaki, Takamasa Kitamura, Tomokazu Hasegawa, Hiroshi Nakagawa and Tomonori Iwasaki : 当院小児摂食嚥下外来における初診時調査, The Japanese Journal of Pediatric Dentistry, Vol.61, 53-54, Feb. 2023.
7.	KIMU Suha, Keiichiro Watanabe, Kaoru Yoshinaga, Hirofumi Tenshin, Emiko Nakaue, Yoshiki Higa, 坂本幸, 近藤英司, Aki Shimada, Kazuhide Mineda, Soushi Ishida, Aya Miyazaki, Takamasa Kitamura, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口唇口蓋裂センター設立前後での患者動向の変化金秀河(徳島大学大学院口腔科学教育部口腔顎顔面矯正学分野), 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩崎智憲, 橋本一郎, 田中栄二日本口蓋裂学会雑誌(0386-5185)47巻2号 Page135(2022.04), Journal fo Japanese Cleft Palate Association, Vol.47, No.2, 135, May 2022.
8.	MAEO Kei, Takamasa Kitamura, KOHIRA Wakana, 石井瞳, 嘉ノ海龍三 and Tomonori Iwasaki : 低位舌と上顎歯列形態ならびに鼻腔通気状態との関連流体力学的研究, The Japanese Journal of Pediatric Dentistry, Vol.60, No.2, 103, Mar. 2022.
9.	Asuna Sugimoto, Takamasa Kitamura, MAEO Kei, Tomonori Iwasaki and Tsutomu Iwamoto : 心停止の既往がある先天性QT延長症候群の児に対し口腔内管理を行った1例, The Japanese Journal of Pediatric Dentistry, Vol.60, No.2, 205, Mar. 2022.
10.	Takamasa Kitamura, KOHIRA Wakana, MAEO Kei, 岩本勉 and Tomonori Iwasaki : 幼児期の骨破壊性病変が及ぼす顎口腔発育への影響, The Japanese Journal of Pediatric Dentistry, Vol.60, No.2, 202, Mar. 2022.
11.	Rie Niji, Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura and Tomonori Iwasaki : Streptococcus mutans定着時期に低濃度フッ素化合物を応用した小児の5歳時の齲蝕罹患状況, The Japanese Journal of Pediatric Dentistry, Vol.60, No.2, 55-56, Feb. 2022. (Keyword) Streptococcus mutans う蝕(予防,予後) *フッ素(治療的利用) ヒト乳児(1∼23ヶ月) 幼児(2∼5) 歯学
12.	Tomonori Iwasaki, Kei Maeo, Wakana Kohira, Takamasa Kitamura, Keita Kawarabayashi, Aya Miyazaki, Yuki Akazawa, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa and Tomokazu Hasegawa : 小児閉塞性睡眠時無呼吸への対応と展望, 徳島県小児保健協会総会並びに第62回講演会, 3, Sep. 2021.
13.	Keiichiro Watanabe, Hirofumi Tenshin, Kazuhide Mineda, Soushi Ishida, Kaoru Yoshinaga, Emiko Nakaue, Yoshiki Higa, Aya Miyazaki, Takamasa Kitamura, 坂本幸, Eiji Kondou, Aki Shimada, Masahiro Hiasa, Shinya Horiuchi, Ichiro Hashimoto and Eiji Tanaka : 当院における口腔内スキャナーを活用した哺乳床早期装着のための取り組み, Journal fo Japanese Cleft Palate Association, Vol.46, No.2, 123, Apr. 2021. (Keyword) 口蓋裂口唇裂歯科用機器母乳栄養ヒト乳児(1∼23ヶ月) 歯学
14.	Rika Kurogoushi, Kokoro Iwata, Takamasa Kitamura and Tsutomu Iwamoto : 口蓋へのマダニの刺咬が疑われた1例, The Japanese Journal of Pediatric Dentistry, Vol.58, 169, May 2020.
15.	Takamasa Kitamura, Rika Kurogoushi, Kokoro Iwata and Tsutomu Iwamoto : 萌出中の永久歯歯肉溝にシャープペンシルの芯が迷入した1例, The Japanese Journal of Pediatric Dentistry, Vol.58, 170, May 2020.
16.	Yuki Akazawa, Kokoro Iwata, Rika Kurogohshi, Keita Kawarabayashi, Aya Miyazaki, 藤島史帆, Hiroki Mori, Asuna Sugimoto, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto : 本院小児歯科の初診患者の動向と主訴の変遷について, 徳島県歯科医学大会, 29, Feb. 2020.
17.	Asuna Sugimoto, Aya Miyazaki, Keita Kawarabayashi, Kokoro Iwata, Rika Kurogohshi, Yuki Akazawa, Tomokazu Hasegawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Hiroshi Nakagawa and Tsutomu Iwamoto : 象牙芽細胞におけるピエゾ型イオンチャネル1(PIEZO1)の発現とその役割, 第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
18.	黒厚子璃佳, Asuna Sugimoto, Kokoro Iwata, Aya Miyazaki, Keita Kawarabayashi, 藤島史帆, Yuki Akazawa, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Rie Niji, Tomokazu Hasegawa, Hiroshi Nakagawa and Tsutomu Iwamoto : 当科における5年間の障害児の初診時実態調査, 第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
19.	Kokoro Iwata, Asuna Sugimoto, Rika Kurogohshi, Keita Kawarabayashi, Aya Miyazaki, 藤島史帆, Takamasa Kitamura, Yuki Akazawa, Rie Niji, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto : 当科における初診患者の実態調査~平成における30年間の変遷~, 第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
20.	Asuna Sugimoto, Yuki Akazawa, Keita Kawarabayashi, Aya Miyazaki, Kimiko Ueda Yamaguchi, Takamasa Kitamura and Tsutomu Iwamoto : 当科における口腔筋機能療法(MFT)の効果と有用性について, The Japanese Journal of Pediatric Dentistry, Vol.56, No.1, 155, Nov. 2017.
21.	Keita Kawarabayashi, Yuki Akazawa, Asuna Sugimoto, Kimiko Ueda Yamaguchi, Takamasa Kitamura and Tsutomu Iwamoto : 齲蝕罹患と生活習慣の相関とその解決課題, The Japanese Journal of Pediatric Dentistry, Vol.56, No.1, 158, Nov. 2017.
22.	Hiroshi Nakagawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Aya Miyazaki and Tsutomu Iwamoto : Development of the new molecular target therapy for wound healing of oral mucosa : p-HPPH promotes cell migration in human gingival fibroblasts, Journal of the Japanese Society for Disability and Oral Health, Vol.38, No.3, 288, Oct. 2017.
23.	宮嵜彩, Asuna Sugimoto, 井上秀人, Takamasa Kitamura, Kimiko Ueda Yamaguchi, 河原林啓太, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto : 当科における10年間の口唇口蓋裂児の実態調査, 第55回日本小児歯科学会大会, Vol.55, No.2, 183, May 2017.
24.	宮嵜彩, 杉本明日菜, 井上秀人, Takamasa Kitamura, 上田公子, 河原林啓太, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto : 当科における10年間の口唇口蓋裂児の実態調査, The Japanese Journal of Pediatric Dentistry, Vol.55, No.2, 183, 2017.
25.	杉本明日菜, Takamasa Kitamura, Kimiko Ueda Yamaguchi, 河原林啓太, 宮嵜彩 and Tsutomu Iwamoto : 歯牙腫により上顎右側乳中切歯の萌出障害をきたした1歳6か月児の1例, The Japanese Journal of Pediatric Dentistry, Vol.55, No.1, 142-143, Nov. 2016.
26.	Takamasa Kitamura, 杉本明日菜, 河原林啓太 and Tsutomu Iwamoto : 2根管性上顎乳中切歯の存在により後継永久歯の萌出遅延がみられた1例, The Japanese Journal of Pediatric Dentistry, Vol.54, No.1, 139, Oct. 2015.
27.	Rie Niji, Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura, Tomokazu Hasegawa, 杉本明日菜 and Tsutomu Iwamoto : 歯の萌出時期に低濃度フッ素化合物を使用した小児の齲蝕罹患状況, The Japanese Journal of Pediatric Dentistry, Vol.54, No.1, 144, Oct. 2015.
28.	Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura, 杉本明日菜, Tomokazu Hasegawa, Hiroshi Nakagawa and Tsutomu Iwamoto : ヒト歯肉線維芽細胞におけるS-PRGフィラー抽出液による細胞遊走の促進, The Japanese Journal of Pediatric Dentistry, Vol.54, No.1, 145, Oct. 2015.
29.	Kimiko Ueda Yamaguchi, 益富由佳子, Rie Niji, Takamasa Kitamura, Aimi Yamamoto, Yuki Akazawa, 杉本明日菜, 白石真紀, Hiroshi Nakagawa, Tomokazu Hasegawa, Yukiko Kori and Tsutomu Iwamoto : Clinical survey of traumatic dental injuries in children at our outpatient clinic, The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 272, May 2015.
30.	Aimi Yamamoto, Hiroshi Nakagawa, Yukiko Kori, Takamasa Kitamura, 杉本明日菜 and Tsutomu Iwamoto : 小児および障碍児・者への防災意識に関する研究, The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 330, May 2015.
31.	Tomokazu Hasegawa, Yuki Akazawa, 吉村善隆, 帖佐直幸, 浅川剛吉, 杉本明日菜, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, 白石真紀, 石崎明 and Tsutomu Iwamoto : 乳歯歯根膜由来細胞のSDF-1αを介した歯周組織恒常性に関わる細胞間相互作用, The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 222, 2015.
32.	Takamasa Kitamura, Hiroshi Nakagawa, 杉本明日菜, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto : 含歯性嚢胞の間葉系結合組織層が骨吸収に与える影響, 歯基礎誌抄録, 141, 2014.
33.	Hiroshi Nakagawa, Aimi Yamamoto, Yuki Akazawa, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto : p-HPPHを分子標的としたフェニトインによる歯肉増殖症に対する新規治療薬の開発, Journal of the Japanese Society for Disability and Oral Health, Vol.35, No.3, 478, 2014.
34.	Takamasa Kitamura, Yukiko Kori, 赤澤友基, Tomokazu Hasegawa and Tsutomu Iwamoto : 鼻腔底に近接した上顎正中埋伏過剰歯由来の含歯性嚢胞の1例, The Japanese Journal of Pediatric Dentistry, Vol.52, No.2, 306, 2014.
35.	赤澤友基, Tomokazu Hasegawa, 久保-藤原百合, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa and Tsutomu Iwamoto : 当科にて長期的口腔内管理を行った伊藤白斑の1例, The Japanese Journal of Pediatric Dentistry, Vol.52, No.2, 354, 2014.
36.	Tomokazu Hasegawa, 赤澤友基, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa and Tsutomu Iwamoto : 幼児期の小児の口蓋に発生した血管腫の1例, The Japanese Journal of Pediatric Dentistry, Vol.52, No.2, 355, 2014.
37.	Tomokazu Hasegawa, 久保-藤原百合, 赤澤友基, Takamasa Kitamura, Kimiko Ueda Yamaguchi and Tsutomu Iwamoto : 当科において口腔内管理を行ってきた滑脳症を伴った伊藤白斑の1症例, 小児歯誌, Vol.52, No.1, 184-185, 2014.
38.	Kimiko Ueda Yamaguchi, Yukiko Kori, Aimi Yamamoto, 赤澤友基, Takamasa Kitamura, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto : 過剰歯摘出によって歯の位置異常が改善した症例についての検討, 第31回日本小児歯科学会北日本地方会大会, Vol.52, No.1, 122-123, Oct. 2013.
39.	Hiroshi Nakagawa, Aimi Yamamoto, Yukiko Kori, Kimiko Ueda Yamaguchi, 赤澤友基, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto : The longitudinal changes in the results of psychological tests applied to a patient with dental phobia, Journal of the Japanese Society for Disability and Oral Health, Vol.34, No.3, 375, Oct. 2013.
40.	Hiroshi Nakagawa, Aimi Yamamoto, Yukiko Kori, Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto : 歯科治療恐怖症患者に応用した心理検査結果の経時的変化について, Journal of the Japanese Society for Disability and Oral Health, Vol.34, No.3, 375, Sep. 2013.
41.	赤澤友基, 帖佐直行, 吉村善隆, Takamasa Kitamura, Yuri Fujihara, 浅川剛吉, 石崎明 and Tomokazu Hasegawa : Establishment of immortalized dental pulp cell lines derived from human deciduous teeth, The Japanese Journal of Pediatric Dentistry, Vol.51, No.2, 303, Apr. 2013. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572261551063864576 (CiNii: 1572261551063864576)
42.	Hiroshi Nakagawa, Aimi Yamamoto, Yukiko Kori, 赤澤友基, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto : 歯科治療恐怖症患者に応用した心理検査結果の経時的変化について, Journal of the Japanese Society for Disability and Oral Health, Vol.34, No.3, 375, 2013.
43.	Tomokazu Hasegawa, 赤澤友基, 帖佐直行, 吉村善隆, Takamasa Kitamura, Yuri Fujihara, 浅川剛吉 and 石崎明 : ヒト乳歯歯髄細胞株におけるFGF-2によるSDF-1α発現調節機構の解析, 小児歯誌, Vol.51, No.2, 164, 2013.
44.	赤澤友基, Yukiko Kori, Rie Niji, Kimiko Ueda Yamaguchi, Aimi Yamamoto, Tomokazu Hasegawa, Takamasa Kitamura and Yuri Fujihara : 集合性歯牙腫が上顎乳前歯の萌出障害を起こした1症例, 第31回日本小児歯科学会中四国地方会大会及び総会, Vol.51, No.1, 115, Nov. 2012.
45.	Tomokazu Hasegawa, 帖佐直幸, Yuri Fujihara, Takamasa Kitamura, 浅川剛吉, 赤澤友基, 吉村善隆, 石崎明 and Masato Mitome : 乳歯歯根膜はSDF-1αにより間葉系幹細胞の遊走をコントロールし，歯周組織の再生・恒常性に関与している, 小児歯誌, Vol.50, No.2, 240, May 2012.
46.	Yuri Fujihara, Tomokazu Hasegawa, 赤澤友基, Takamasa Kitamura and Masato Mitome : 色素失調症により多数歯欠損がみられた症例, 小児歯誌, Vol.50, No.1, 120, 2012.

Products:

1.	KOHIRA Wakana, Takamasa Kitamura, MAEO Kei, 石井瞳, 嘉ノ海龍三 and Tomonori Iwasaki : 上顎急速拡大にLip Training・MFTを併用することで鼻腔通気障害は改善するか? 鼻粘膜肥厚症例に対して, The Japanese Journal of Pediatric Dentistry, Vol.60, No.2, 125, Mar. 2022.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

小児OSAの歯科的治療は漏斗胸を改善するか？－流体力学的研究－ (Project/Area Number: 23K09416 )
小児鼻腔通気障害に対する歯科的治療法の開拓と治療効果の検討 (Project/Area Number: 22K10274 )
超遠心法による分画抽出血清のプロテオーム解析を利用した新規硬組織形成誘導法の開発 (Project/Area Number: 21K10162 )
Development of a novel therapeutic approach targeting gingipain for regression phenomenon in Down syndrome (Project/Area Number: 20K10204 )
Development of a new method for inducing hard tissue formation using the fraction of serum extracted by the ultracentrifugation. (Project/Area Number: 18K09834 )
Development of the new molecular target therapy for wound healing of oral mucosa (Project/Area Number: 16K11805 )
Elucidation of matrix vesicles secretion mechanism and application to calcification (Project/Area Number: 15K11368 )
Toward the cell therapy for central nerve system disease with stem cells from human exfoliated deciduous teeth (Project/Area Number: 26861791 )
Development of the new molecular target therapy for phenytoin-induced gingival overgrowth using the antagonist of TRPA1 channel (Project/Area Number: 25463180 )
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Assistant Professor : Kitamura, Takamasa

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)