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Research Activity

Field of Study

Dentistry

Subject of Study

root resorption, regenerative medicine

Book / Paper

Book:

1. Tomokazu Hasegawa, 田中 光郎, 帖佐 直幸, 浅川 剛吉 and 角田 初恵 :
乳歯および永久歯歯根膜由来間葉系幹細胞による血管新生誘導および歯周組織再生法の開発,
Apr. 2013.
2. Tomokazu Hasegawa :
乳歯由来不死化歯根膜細胞株の樹立,
Oct. 2011.

Academic Paper (Judged Full Paper):

1. Aya Miyazaki, Asuna Sugimoto, Yoshizaki Keigo, Keita Kawarabayashi, Kokoro Iwata, Rika Kurogohshi, Takamasa Kitamura, Kunihiro Otsuka, Tomokazu Hasegawa, Yuki Akazawa, Fukumoto Satoshi, Naozumi Ishimaru and Tsutomu Iwamoto :
Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1,
Scientific Reports, Vol.9, 14762, 2019.
(DOI: 10.1038/s41598-019-51381-9)
2. Kimiko Ueda Yamaguchi, Yuki Akazawa, Kawarabayashi Keita, Asuna Sugimoto, Hiroshi Nakagawa, miyazaki aya, Weih Falk, Kurogoushi Rika, Iwata Kokoro, Takamasa Kitamura, Yamada Aya, Tomokazu Hasegawa, Fukumoto Satoshi and Tsutomu Iwamoto :
Combination of ions promotes cell migration via extracellular signalregulated kinase 1/2 signaling pathway in human gingival fibroblasts.,
Molecular Medicine Reports, Vol.19, No.6, 5039-5045, 2019.
(Tokushima University Institutional Repository: 113289,   DOI: 10.3892/mmr.2019.10141,   PubMed: 31059063,   Elsevier: Scopus)
3. Kifune Takashi, Ito Hisanori, Ishiyama Misa, Iwasa Satoko, Takei Hiroki, Tomokazu Hasegawa, Asano Masatake and Tetsuo Shirakawa :
Hypoxia-induced up-regulation of angiogenic factors in immortalized human periodontal ligament fibroblasts,
Journal of Oral Science, Vol.60, No.4, 519-525, 2018.
(DOI: 10.2334/josnusd.17-0441,   PubMed: 30587686,   Elsevier: Scopus)
4. Ito Hisanori, Kifune Takashi, Ishiyama Misa, Iwasa Satoko, Takei Hiroki, Tomokazu Hasegawa, Asano Masatake and Shirakawa Tetsuo :
Effect of hypoxia on the expression of CCAAT/enhancer-binding protein β and receptor activator of NF-κB ligand in periodontal ligament cells,
Journal of Oral Science, Vol.60, No.4, 544-551, 2018.
(DOI: 10.2334/josnusd.17-0436,   PubMed: 30587688,   Elsevier: Scopus)
5. Asuna Sugimoto, Aya Miyazaki, Keita Kawarabayashi, Masayuki Shono, Yuki Akazawa, Tomokazu Hasegawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Yoshizaki keigo, Fukumoto Satoshi and Tsutomu Iwamoto :
Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells,
Scientific Reports, Vol.7, No.1, 17696, 2017.
(Tokushima University Institutional Repository: 112396,   DOI: 10.1038/s41598-017-18089-0,   PubMed: 29255201,   Elsevier: Scopus)
6. Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Mino Matsuno, Hajime Minamikawa, Yoshiaki Deyama and Kuniaki Suzuki :
How much medium do you use for cell culture? Medium volume influences mineralization and osteoclastogenesis in vitro,
Molecular Medicine Reports, Vol.16, No.1, 429-434, 2017.
(DOI: 10.3892/mmr.2017.6611,   PubMed: 28535008)
7. Nan Ma, Di Yang, Hirohiko Okamura, Jumpei Teramachi, Tomokazu Hasegawa, Lihong Qiu and Tatsuji Haneji :
Involvement of interleukin23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis,
Molecular Medicine Reports, Vol.15, No.2, 559-566, 2017.
(DOI: 10.3892/mmr.2016.6041,   PubMed: 28000855)
8. Masaaki Ikeda, Yoshitaka Yoshimura, Takashi Kikuiri, Mino Matsuo, Tomokazu Hasegawa, Kumu Fukushima, Takako Hayakawa, Hajime Minamikawa, Kuniaki Suzuki and Junichiro Iida :
Release from optimal compressive force suppresses osteoclast differentiation,
Molecular Medicine Reports, Vol.14, No.5, 4699-4705, 2016.
(DOI: 10.3892/mmr.2016.5801,   PubMed: 27748817)
9. Takako Hayakawa, Yoshitaka Yoshimura, Takashi Kikuiri, Mino Matsuno, Tomokazu Hasegawa, Kumu Fukushima, Kenjiro Shibata, Yoshiaki Deyama, Kuniaki Suzuki and Junichiro Iida :
Optimal compressive force accelerates osteoclastogenesis in RAW264.7 cells,
Molecular Medicine Reports, Vol.12, No.4, 5879-5885, 2015.
(DOI: 10.3892/mmr.2015.4141,   PubMed: 26238100,   Elsevier: Scopus)
10. Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Kimiko Ueda Yamaguchi, Asuna Sugimoto, Takamasa Kitamura, Hiroshi Nakagawa, Akira Ishisaki and Tsutomu Iwamoto :
Recruitment of mesenchymal stem cells by stromal cell-derived factor 1 in pulp cells from deciduous teeth,
International Journal of Molecular Medicine, Vol.36, 442-448, 2015.
(DOI: 10.3892/ijmm.2015.2247,   PubMed: 26082290,   Elsevier: Scopus)
11. Tomokazu Hasegawa, Yuki Akazawa, Takamasa Kitamura, Asuna Sugimoto, Kimiko Ueda Yamaguchi and Tsutomu Iwamoto :
Dental findings and management in a child with hypomelanosis of Ito,
Pediatric Dental Journal, Vol.24, No.3, 173-177, 2014.
(DOI: 10.1016/j.pdj.2014.08.002,   Elsevier: Scopus)
12. Emiko Aomatsu, Noriko Takahashi, Shunsuke Sawada, Naoto Okubo, Tomokazu Hasegawa, Masayuki Taira, Hiroyuki Miura, Akira Ishisaki and Naoyuki Chosa :
Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells,
Scientific Reports, Vol.4, 3652, 2014.
(DOI: 10.1038/srep03652,   PubMed: 24413464,   Elsevier: Scopus)
13. Tomokazu Hasegawa, Yuki Akazawa, Hirokazu Nagai, Takamasa Kitamura, Naozumi Ishimaru, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Yukiko Kori, Aimi Yamamoto and Tsutomu Iwamoto :
Capillary Hemangioma on Palate of Infant:Case Report,
The Japanese Journal of Pediatric Dentistry, Vol.52, No.3, 448-453, 2014.
(DOI: 10.11411/jspd.52.3_448,   CiNii: 130005084435)
14. Yuki Akazawa, Takamasa Kitamura, Yuri Fujihara, Masato Mitome and Tomokazu Hasegawa :
Forced mastication increase survival of neural stem cell in the hippocampal dentate gyrus,
International Journal of Molecular Medicine, Vol.31, 307-314, 2012.
15. Yuki Akazawa, Takamasa Kitamura, Yuri Fujihara, Yoshitaka Yoshimura, Masato Mitome and Tomokazu Hasegawa :
Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus.,
International Journal of Molecular Medicine, Vol.31, No.2, 307-314, 2012.
(DOI: 10.3892/ijmm.2012.1217,   PubMed: 23254518)
16. Mariko Yoshida, Naoto Okubo, Naoyuki Chosa, Tomokazu Hasegawa, Miho Ibi, Masaharu Kamo, Seiko Kyakumoto and Akira Ishisaki :
TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals.,
International Journal of Biological Sciences, Vol.8, No.7, 1062-1074, 2012.
(DOI: 10.7150/ijbs.4488,   PubMed: 22949889)
17. Tomokazu Hasegawa, Naoyuki Chosa, Takeyoshi Asakawa, Yoshitaka Yoshimura, Yuri Fujihara, Takamasa Kitamura, Mitsuro Tanaka, Akira Ishisaki and Masato Mitome :
Differential effects of TGF-β1 and FGF-2 on SDF-1α expression in human periodontal ligament cells derived from deciduous teeth in vitro.,
International Journal of Molecular Medicine, Vol.30, No.1, 35-40, 2012.
(DOI: 10.3892/ijmm.2012.957,   PubMed: 22469823)
18. Keigo Abe, Yoshitaka Yoshimura, Yoshiaki Deyama, Tkashi Kikuiri, Tomokazu Hasegawa, Kanchu Tei, Hisashi shinoda, Kuniaki Suzuki and Yoshimasa Kitagawa :
Effects of bisphosphonates on osteoclastogenesis in RAW264.7 cells.,
International Journal of Molecular Medicine, Vol.29, No.6, 1007-1015, 2012.
(DOI: 10.3892/ijmm.2012.952,   PubMed: 22447156)
19. Yuri Fujihara, 赤澤 友基, Takamasa Kitamura, Tomokazu Hasegawa and Masato Mitome :
色素失調症により多数歯欠損が認められた症例,
障害者歯科学雑誌, Vol.33, No.1, 74-79, 2012.
(CiNii: 10030300445)
20. Takeyoshi Asakawa, Naoyuki Chosa, Yoshitaka Yoshimura, Asami Asakawa, Mitsuro Tanaka, Akira Ishisaki, Masato Mitome and Tomokazu Hasegawa :
Fibroblast growth factor 2 inhibits the expression of stromal cell-derived factor 1 in periodontal ligament cells derived from human permanent teeth in vitro.,
International Journal of Molecular Medicine, Vol.29, No.4, 569-573, 2012.
(DOI: 10.3892/ijmm.2011.869,   PubMed: 22200847)
21. Mayumi Nomura, Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Yumi Taniguchi, Yoshiaki Deyama, Ken-ichi Koshiro, Hidehiko Sano, Kuniaki Suzuki and Nobuo Inoue :
Platinum nanoparticles suppress osteoclastogenesis through scavenging of ROS productions in RAW264.7 cells.,
Journal of Pharmacological Sciences, Vol.117, No.4, 243-252, 2011.
(DOI: 10.1254/jphs.11099FP,   PubMed: 22083043)
22. Takashi Kikuiri, Yoshitaka Yoshimura, Futoshi Tabata, Tomokazu Hasegawa, Jun Nishihira and Tetsuo Shirakawa :
Stage-dependent suppression of the formation of dentin-resorbing multinuclear cells with migration inhibitory factor in vitro.,
Experimental and Therapeutic Medicine, Vol.3, No.1, 37-43, 2011.
(DOI: 10.3892/etm.2011.362,   PubMed: 22969841)
23. Noriko Takahashi, Naoyuki Chosa, Tomokazu Hasegawa, Soko Nishihira, Naoto Okubo, Mamoru Takahashi, Yoshiki Sugiyama, Mitsuro Tanaka and Akira Ishisaki :
Dental pulp cells derived from permanent teeth express higher levels of R-cadherin than do deciduous teeth: implications of the correlation between R-cadherin expression and restriction of multipotency in mesenchymal stem cells.,
Archives of Oral Biology, Vol.57, No.1, 44-51, 2011.
(DOI: 10.1016/j.archoralbio.2011.07.013,   PubMed: 21851926)
24. Kenjiro Shibata, Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Yumi Taniguchi, Yoshiaki Deyama, Kuniaki Suzuki and Junichiro Iida :
Effect of the release from mechanical stress on osteoclastogenesis in RAW264.7 cells.,
International Journal of Molecular Medicine, Vol.28, No.1, 73-79, 2011.
(DOI: 10.3892/ijmm.2011.675,   PubMed: 21491081)

Academic Paper (Unrefereed Paper):

1. Takeyoshi Asakawa, Naoyuki Chosa, Tomokazu Hasegawa, Asami Asakawa, Akira Isisaki and Mituro Tanaka :
Regulation of SDF-1 expression in periodontal ligament cells derived from human permanent teeth,
Interface oral health science 2011, 107-109, 2012.
(DOI: 10.1007/978-4-431-54070-0_22,   Elsevier: Scopus)
2. Tomokazu Hasegawa, Naoyuki Chosa, Takeyoshi Asakawa, Yoshitaka Yoshimura, Akira Ishisaki and Mitsuro Tanaka :
Eatablishment of periodontal ligament cell line derived from human deciduous teeth,
Interface oral health science 2011, 114-116, 2012.

Review, Commentary:

1. Kimiko Ueda Yamaguchi, Keita Kawarabayashi, Aya Miyazaki, Rika Kurogohshi, Kokoro Iwata, Asuna Sugimoto, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
Prevention of Sports-related Dental Injuries in Children,
Journal of Oral Health and Biosciences, Vol.31, No.1, 68-72, Jul. 2018.
(Tokushima University Institutional Repository: 111941,   DOI: 10.20738/johb.31.1_68,   CiNii: 130007402944)
2. Tsutomu Iwamoto, Asuna Sugimoto, Takamasa Kitamura, Yuki Akazawa and Tomokazu Hasegawa :
The role of extracellular ATP-mediated purinergic signaling in bone, cartilage, and tooth tissue,
Journal of Oral Biosciences, Vol.56, No.4, 131-135, Jul. 2014.
(DOI: 10.1016/j.job.2014.07.003,   Elsevier: Scopus)
3. Tomokazu Hasegawa :
乳歯歯根膜細胞による再生医学研究の可能性の検討,
小児歯科学雑誌, Vol.50, No.1, 7-14, Jan. 2012.

Proceeding of International Conference:

1. Takeyoshi Asakawa, Yoichi Miyamoto, Kentaro Yoshimura, Kiyoto Sasa, Yoko Manome, Ryutaro Kamijo, Tomokazu Hasegawa, Naoyuki Chosa, Akira Ishizaki, Masumi Ookawa, Tomomi Sugiyama, Masayasu Shige and Yukie Shimada :
Establish of expression on differentiation periodontal ligament cells derived from human teeth-Cooparative analysis that SDF-1 regulation of expression on periodontal ligament cells derived from Down syndrome teeth,
116, 2017.
2. Kimiko Ueda Yamaguchi, Asuna Sugimoto, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
Multi-ion solution promotes cell migration through ERK signaling pathway and CXCR4 expression in human gingival of fibroblasts,
10th Biennial Conferrence of the Pediatric Dentistry Association of Asia, Vol.54, No.2, 346, Tokyo, May 2016.
3. Takeyoshi Asakawa, Yoichi Miyamoto, Kentaro Yoshimura, Sasa Kiyoto, Tomokazu Hasegawa, Naoyuki Chosa, Akira Ishizaki, Miki Kadena, Yoko Manome, Miku Kuritani, Ryutaro Kamijo and Takahiro Funatsu :
Establishing and SDF-1 regulation of expression on periodontal ligament cells derived from human teeth,
The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 354, May 2016.
4. Takeyoshi Asakawa, Naoyuki Chosa, Tomokazu Hasegawa, Asami Asakawa, Akira Ishisaki and Mitsuro Tanaka :
Regulation of SDF-1 expression in periodontal ligament cells derived from human permanent teeth.,
Interface oral health science 2011, 107-109, 2012.
5. Tomokazu Hasegawa, Naoyuki Chosa, Takeyoshi Asakawa, Yoshimura Yoshitaka, Akira Ishisaki and Mitsuro Tanaka :
Eatablishment of periodontal ligament cell line derived from human deciduous teeth.,
Interface oral health science 2011, 114-116, 2012.

Proceeding of Domestic Conference:

1. 浅川 剛吉, 久木野 真純, Tomokazu Hasegawa, 浅川 麻美, 吉村 健太郎, 笹 清人, 松島 瞳, 新田 雅一, 永田 夏琳, 若月 宏之, 杉山 智美, 島田 幸恵, 上條 竜太郎 and 船津 多敬弘 :
ダウン症候群永久歯歯根膜由来細胞のマイクロアレイ比較解析,
The Japanese Journal of Pediatric Dentistry, Vol.58, No.2, 237, 2019.
2. Asuna Sugimoto, Aya Miyazaki, Keita Kawarabayashi, Kokoro Iwata, Rika Kurogohshi, Yuki Akazawa, Tomokazu Hasegawa, Kimiko Ueda Yamaguchi, Takamasa Kitamura, Hiroshi Nakagawa and Tsutomu Iwamoto :
象牙芽細胞におけるピエゾ型イオンチャネル1(PIEZO1)の発現とその役割,
第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
3. 黒厚子 璃佳, Asuna Sugimoto, Kokoro Iwata, Aya Miyazaki, Keita Kawarabayashi, 藤島 史帆, Yuki Akazawa, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Rie Niji, Tomokazu Hasegawa, Hiroshi Nakagawa and Tsutomu Iwamoto :
当科における5年間の障害児の初診時実態調査,
第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
4. Kokoro Iwata, Asuna Sugimoto, Rika Kurogohshi, Keita Kawarabayashi, Aya Miyazaki, 藤島 史帆, Takamasa Kitamura, Yuki Akazawa, Rie Niji, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
当科における初診患者の実態調査~平成における30年間の変遷~,
第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
5. Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
外傷により両側顎関節完全脱臼を呈した5歳男児の1例,
第37回日本小児歯科学会中四国地方会大会, Nov. 2018.
6. Rika Kurogohshi, Tomokazu Hasegawa, Yuki Akazawa, Asuna Sugimoto, Keita Kawarabayashi, Kimiko Ueda Yamaguchi and Tsutomu Iwamoto :
乳歯歯髄細胞におけるExotaxin-1の発現調節機構の解析,
The Japanese Journal of Pediatric Dentistry, Vol.56, No.2, 215, May 2018.
7. 浅川 剛吉, 大川 真澄, 永田 夏琳, Tomokazu Hasegawa, 宮本 洋一, 吉村 健太, 笹 清人, 馬目 瑤子, 杉山 智美, 上條 竜太郎 and 島田 幸恵 :
Down症候群乳歯歯根膜由来細胞のDYRK1A発現解析,
The Japanese Journal of Pediatric Dentistry, Vol.56, No.2, 211, May 2018.
8. 黒厚子 璃佳, Yuki Akazawa, Tomokazu Hasegawa, Asuna Sugimoto, Kimiko Ueda Yamaguchi and Tsutomu Iwamoto :
乳歯歯髄細胞におけるケモカインCCL11の発現解析,
The Japanese Journal of Pediatric Dentistry, Vol.56, No.1, 154, Nov. 2017.
9. 宮嵜 彩, Asuna Sugimoto, 井上 秀人, Takamasa Kitamura, Kimiko Ueda Yamaguchi, 河原林 啓太, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
当科における10年間の口唇口蓋裂児の実態調査,
第55回日本小児歯科学会大会, Vol.55, No.2, 183, May 2017.
10. 林 光一, 村澤 瑛里子, Tomokazu Hasegawa and Tsutomu Iwamoto :
ヒト乳歯歯髄細胞によるSDF-1αの発現はTGF-βを介してFGF-2により負に制御されている,
Journal of Oral Health and Biosciences, Mar. 2017.
11. 杉本 明日菜, Yuki Akazawa, Tomokazu Hasegawa, 宮嵜 彩, 河原林 啓太 and Tsutomu Iwamoto :
PIEZO1は歯髄細胞の分化運命決定に関与し,象牙芽細胞への分化を促進させる,
The Japanese Journal of Pediatric Dentistry, Vol.55, No.2, 290, 2017.
12. 木舩 崇, 伊藤 寿典, 石山 未紗, 武井 浩樹, Tomokazu Hasegawa and Tetsuo Shirakawa :
低酸素暴露が株化歯根膜細胞の血管新生因子産生に及ぼす影響,
The Japanese Journal of Pediatric Dentistry, Vol.55, No.2, 287, 2017.
13. 宮嵜 彩, 杉本 明日菜, 井上 秀人, Takamasa Kitamura, 上田 公子, 河原林 啓太, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
当科における10年間の口唇口蓋裂児の実態調査,
The Japanese Journal of Pediatric Dentistry, Vol.55, No.2, 183, 2017.
14. Yuki Akazawa, Tomokazu Hasegawa, 帖佐 直幸, 吉村 善隆, 浅川 剛吉, 杉本 明日菜, 河原林 啓太, 宮嵜 彩, 石崎 明 and Tsutomu Iwamoto :
ヒト乳歯歯髄細胞のSDF-1発現調節機構におけるALK5の関与について,
The Japanese Journal of Pediatric Dentistry, Vol.55, No.2, 291, 2017.
15. Yuki Akazawa, 上田 公子, Tomokazu Hasegawa and Tsutomu Iwamoto :
低位下顎左側第二乳臼歯の再萌出を認めた1例,
The Japanese Journal of Pediatric Dentistry, Vol.55, No.1, 141-142, 2017.
16. Yuki Akazawa, Kimiko Ueda Yamaguchi, Tomokazu Hasegawa and Tsutomu Iwamoto :
低位下顎左側第二乳臼歯の再萌出を認めた1例,
The Japanese Journal of Pediatric Dentistry, Vol.55, No.1, 141-142, Nov. 2016.
17. Rie Niji, Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura, Tomokazu Hasegawa, 杉本 明日菜 and Tsutomu Iwamoto :
歯の萌出時期に低濃度フッ素化合物を使用した小児の齲蝕罹患状況,
The Japanese Journal of Pediatric Dentistry, Vol.54, No.1, 144, Oct. 2015.
18. Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura, 杉本 明日菜, Tomokazu Hasegawa, Hiroshi Nakagawa and Tsutomu Iwamoto :
ヒト歯肉線維芽細胞におけるS-PRGフィラー抽出液による細胞遊走の促進,
The Japanese Journal of Pediatric Dentistry, Vol.54, No.1, 145, Oct. 2015.
19. Kimiko Ueda Yamaguchi, 益富 由佳子, Rie Niji, Takamasa Kitamura, Aimi Yamamoto, Yuki Akazawa, 杉本 明日菜, 白石 真紀, Hiroshi Nakagawa, Tomokazu Hasegawa, Yukiko Kori and Tsutomu Iwamoto :
Clinical survey of traumatic dental injuries in children at our outpatient clinic,
The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 272, May 2015.
20. 浅川 剛吉, 宮本 洋一, 吉村 健太郎, Tomokazu Hasegawa, 帖佐 直幸, 石崎 明, 山下 一恵, 嘉手納 未季, 馬目 瑤子, 栗谷 未来, 上條 竜太郎 and 船津 敬弘 :
ヒトDown症候群歯根膜由来細胞におけるSDF-1α発現解析,
The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 265, 2015.
21. Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
象牙質修復に関わる間葉系幹細胞の乳歯歯髄細胞由来SDF-1αによる制御,
The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 221, 2015.
22. Tomokazu Hasegawa, Yuki Akazawa, 吉村 善隆, 帖佐 直幸, 浅川 剛吉, 杉本 明日菜, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa, 白石 真紀, 石崎 明 and Tsutomu Iwamoto :
乳歯歯根膜由来細胞のSDF-1αを介した歯周組織恒常性に関わる細胞間相互作用,
The Japanese Journal of Pediatric Dentistry, Vol.53, No.2, 222, 2015.
23. 幸江 真杉, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
先天性気管狭窄症に対する口腔内衛生管理の1例,
The Japanese Journal of Pediatric Dentistry, Vol.53, No.1, 168, 2015.
24. 浅川 剛吉, 宮本 洋一, 吉村 健太郎, Tomokazu Hasegawa, 山下 一恵, 嘉手納 美季, 馬目 瑤子, 栗谷 未来, 上条 竜太郎 and 船津 敬弘 :
ヒトDown症乳歯歯根膜細胞のSDF-1発現調節の解析,
Journal of the Japanese Society for Disability and Oral Health, Vol.35, No.3, 278, 2014.
25. 吉村 善隆, 早川 貴子, Tomokazu Hasegawa, 出山 義昭, 鈴木 邦明 and 飯田 順一郎 :
至適圧縮力は破骨細胞分化を促進する,
歯基礎誌抄録, 189, 2014.
26. Takamasa Kitamura, Hiroshi Nakagawa, 杉本 明日菜, Yuki Akazawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
含歯性嚢胞の間葉系結合組織層が骨吸収に与える影響,
歯基礎誌抄録, 141, 2014.
27. Hiroshi Nakagawa, Aimi Yamamoto, Yuki Akazawa, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto :
p-HPPHを分子標的としたフェニトインによる歯肉増殖症に対する新規治療薬の開発,
Journal of the Japanese Society for Disability and Oral Health, Vol.35, No.3, 478, 2014.
28. Takamasa Kitamura, Yukiko Kori, 赤澤 友基, Tomokazu Hasegawa and Tsutomu Iwamoto :
鼻腔底に近接した上顎正中埋伏過剰歯由来の含歯性嚢胞の1例,
The Japanese Journal of Pediatric Dentistry, Vol.52, No.2, 306, 2014.
29. 赤澤 友基, Tomokazu Hasegawa, 久保-藤原 百合, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa and Tsutomu Iwamoto :
当科にて長期的口腔内管理を行った伊藤白斑の1例,
The Japanese Journal of Pediatric Dentistry, Vol.52, No.2, 354, 2014.
30. Tomokazu Hasegawa, 赤澤 友基, Takamasa Kitamura, Kimiko Ueda Yamaguchi, Hiroshi Nakagawa and Tsutomu Iwamoto :
幼児期の小児の口蓋に発生した血管腫の1例,
The Japanese Journal of Pediatric Dentistry, Vol.52, No.2, 355, 2014.
31. Tomokazu Hasegawa, 赤澤 友基, Hiroshi Nakagawa, 上田 公子 and Tsutomu Iwamoto :
乳歯歯髄細胞による細胞走化性因子の調節機構,
The Japanese Journal of Pediatric Dentistry, Vol.52, No.1, 125-126, 2014.
32. Tomokazu Hasegawa, 久保-藤原 百合, 赤澤 友基, Takamasa Kitamura, Kimiko Ueda Yamaguchi and Tsutomu Iwamoto :
当科において口腔内管理を行ってきた滑脳症を伴った伊藤白斑の1症例,
小児歯誌, Vol.52, No.1, 184-185, 2014.
33. Kimiko Ueda Yamaguchi, Aimi Yamamoto, Yukiko Kori, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
上顎中切歯の萌出遅延を起こした集合性歯牙腫の1症例,
第32回日本小児歯科学会中四国地方会大会, Vol.52, No.1, 180-181, Nov. 2013.
34. Kimiko Ueda Yamaguchi, Yukiko Kori, Aimi Yamamoto, 赤澤 友基, Takamasa Kitamura, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
過剰歯摘出によって歯の位置異常が改善した症例についての検討,
第31回日本小児歯科学会北日本地方会大会, Vol.52, No.1, 122-123, Oct. 2013.
35. Hiroshi Nakagawa, Aimi Yamamoto, Yukiko Kori, Kimiko Ueda Yamaguchi, 赤澤 友基, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto :
The longitudinal changes in the results of psychological tests applied to a patient with dental phobia,
Journal of the Japanese Society for Disability and Oral Health, Vol.34, No.3, 375, Oct. 2013.
36. Tomokazu Hasegawa, Yuki Akazawa, 帖佐 直幸, 吉村 善隆, 浅川 剛吉, 石崎 明 and Tsutomu Iwamoto :
ヒト乳歯歯髄細胞におけるSDF-1の発現調節機構,
第55回歯科基礎医学会学術大会, Sep. 2013.
37. Yuki Akazawa, Tomokazu Hasegawa, 帖佐 直幸, 吉村 善隆, 浅川 剛吉, 石崎 明 and Tsutomu Iwamoto :
ヒト乳歯歯髄細胞由来の不死化細胞は骨および脂肪細胞への分化能を持つ,
第55回歯科基礎医学会学術大会, Sep. 2013.
38. Hiroshi Nakagawa, Aimi Yamamoto, Yukiko Kori, Kimiko Ueda Yamaguchi, Yuki Akazawa, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto :
歯科治療恐怖症患者に応用した心理検査結果の経時的変化について,
Journal of the Japanese Society for Disability and Oral Health, Vol.34, No.3, 375, Sep. 2013.
39. 赤澤 友基, 帖佐 直行, 吉村 善隆, Takamasa Kitamura, Yuri Fujihara, 浅川 剛吉, 石崎 明 and Tomokazu Hasegawa :
Establishment of immortalized dental pulp cell lines derived from human deciduous teeth,
小児歯誌, Vol.51, No.2, 303, Apr. 2013.
(CiNii: 10031169155)
40. 上田 公子, Aimi Yamamoto, Yukiko Kori, Hiroshi Nakagawa, Tomokazu Hasegawa and Tsutomu Iwamoto :
上顎中切歯の萌出遅延を起こした集合性歯牙腫の1症例,
The Japanese Journal of Pediatric Dentistry, Vol.52, No.1, 180-181, 2013.
41. 吉村 善隆, 亀山 純香, 菊入 崇, Tomokazu Hasegawa, 出山 義昭, 鈴木 邦明 and 飯田 順一郎 :
機械的刺激はDC-STAMPの発現抑制によりRAW264.7細胞の破骨細胞分化誘導を抑制する,
歯基礎誌抄録, 205, 2013.
42. 横田 潤, 帖佐 直幸, 高橋 典子, 衣斐 美歩, 客本 斉子, 加茂 政晴, Tomokazu Hasegawa, 近藤 尚知 and 石崎 明 :
複数サイトカインによる同時刺激は間葉系幹細胞の骨分化誘導能を促進する,
歯基礎誌抄録, 189, 2013.
43. 青松 恵美子, 帖佐 直幸, 衣斐 美歩, 客本 斉子, 加茂 政晴, Tomokazu Hasegawa, 佐藤 和郎, 三浦 廣行 and 石崎 明 :
間葉系幹細胞が分泌するSCRG1は骨分化を抑制する,
歯基礎誌抄録, 188, 2013.
44. 赤澤 友基, Tomokazu Hasegawa, 帖佐 直幸, 吉村 善隆, 浅川 剛吉, 石崎 明 and Tsutomu Iwamoto :
ヒト乳歯歯髄組織由来の不死化細胞は骨および脂肪細胞への分化能を持つ,
歯科基礎誌抄録, 188, 2013.
45. Tomokazu Hasegawa, 赤澤 友基, 帖佐 直幸, 吉村 善隆, 浅川 剛吉, 石崎 明 and Tsutomu Iwamoto :
ヒト乳歯歯髄細胞におけるSDF-1の発現調節機構,
歯科基礎誌抄録, 192, 2013.
46. Hiroshi Nakagawa, Aimi Yamamoto, Yukiko Kori, 赤澤 友基, Takamasa Kitamura, Tomokazu Hasegawa and Tsutomu Iwamoto :
歯科治療恐怖症患者に応用した心理検査結果の経時的変化について,
Journal of the Japanese Society for Disability and Oral Health, Vol.34, No.3, 375, 2013.
47. Tomokazu Hasegawa, 赤澤 友基, 帖佐 直行, 吉村 善隆, Takamasa Kitamura, Yuri Fujihara, 浅川 剛吉 and 石崎 明 :
ヒト乳歯歯髄細胞株におけるFGF-2によるSDF-1α発現調節機構の解析,
小児歯誌, Vol.51, No.2, 164, 2013.
48. 赤澤 友基, Yukiko Kori, Rie Niji, Kimiko Ueda Yamaguchi, Aimi Yamamoto, Tomokazu Hasegawa, Takamasa Kitamura and Yuri Fujihara :
集合性歯牙腫が上顎乳前歯の萌出障害を起こした1症例,
第31回日本小児歯科学会 中四国地方会大会及び総会, Vol.51, No.1, 115, Nov. 2012.
49. Tomokazu Hasegawa, 帖佐 直幸, Yuri Fujihara, Takamasa Kitamura, 浅川 剛吉, 赤澤 友基, 吉村 善隆, 石崎 明 and Masato Mitome :
乳歯歯根膜はSDF-1αにより間葉系幹細胞の遊走をコントロールし,歯周組織の再生・恒常性に関与している,
小児歯誌, Vol.50, No.2, 240, May 2012.
50. Yuri Fujihara, Tomokazu Hasegawa, 赤澤 友基, Takamasa Kitamura and Masato Mitome :
色素失調症により多数歯欠損がみられた症例,
小児歯誌, Vol.50, No.1, 120, 2012.
51. Tomokazu Hasegawa :
乳歯歯根膜細胞による再生医学研究の可能性の検討,
小児歯科学雑誌, Vol.49, No.41, 51, Jan. 2011.
52. 吉田 茉莉子, 大久保 直登, 帖佐 直幸, Tomokazu Hasegawa, 高橋 典子, 衣斐 美歩, 客本 斉子, 加茂 政晴 and 石崎 明 :
歯周靭帯由来細胞の血管構成細胞分化におけるTGF-βの関与について,
歯基礎誌, Vol.53, 139, 2011.
53. 高橋 美香子, 大久保 直登, 帖佐 直幸, 高橋 典子, Tomokazu Hasegawa, 客本 斉子, 加茂 政晴, 水城 春美 and 石崎 明 :
歯周靭帯由来線維芽細胞の増殖と平滑筋分化はFGFで誘導されるERKシグナルにより制御される,
歯基礎誌, Vol.35, 182, 2011.
54. 浅川 剛吉, 帖佐 直幸, Tomokazu Hasegawa, 浅川 麻美, 石崎 明 and 田中 光郎 :
ヒト永久歯歯根膜細胞におけるSDF-1発現調節の解析,
The Japanese Journal of Pediatric Dentistry, Vol.49, No.4, 367, 2011.
55. Tomokazu Hasegawa, 帖佐 直幸, 浅川 剛吉, 浅川 麻美, 吉村 善隆, 石崎 明 and 田中 光郎 :
ヒト乳歯歯根膜細胞におけるFGF-2およびTGF-β1によるSDF-1発現への影響,
小児歯誌, Vol.49, No.4, 368, 2011.
56. 福本 敏, 吉崎 恵悟, 山田 亜矢, 山本 晋也, Tsutomu Iwamoto, 湯浅 健司, Tomokazu Hasegawa, 福本 恵美子 and 野中 和明 :
エナメル芽細胞の分化機構とその制御,
第30回分子生物学会,第80回生化学会合同年会ワークショップ「歯の発生・再生の分子メカニズム」, Dec. 2007.
57. 新垣 真紀子, 山田 亜矢, 湯浅 健司, 野中 和明, Tomokazu Hasegawa, 岡 暁子, Tsutomu Iwamoto and 福本 敏 :
下顎第二乳臼歯の完全埋伏や萠出異常を認めた症例,
第25回日本小児歯科学会九州地方会大会, Nov. 2007.
58. 福本 敏, 自見 英治郎, 福島 秀文, Tsutomu Iwamoto, 山田 亜矢, 湯浅 健司, Tomokazu Hasegawa, 福本 恵美子, 山口 登 and 野中 和明 :
歯冠幅径を規定する分子シグナルの同定,
第45回日本小児歯科 学会大会, Jul. 2007.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Cell fate determination of mesenchymal stem cells by extracellular mechanical stress (Project/Area Number: 17H04414 )
  • 歯根膜組織の再生・恒常性維持マシナリーに関与する新機能の探索および応用法の開発 (Project/Area Number: 16K11804 )
  • 骨髄間質細胞由来因子による歯周組織再生療法の開発-Down症歯根膜細胞の解析ー (Project/Area Number: 16K11812 )
  • Elucidation of matrix vesicles secretion mechanism and application to calcification (Project/Area Number: 15K11368 )
  • role of preodontoblast in tooth development (Project/Area Number: 26293435 )
  • Study of periodontal ligament tissue function about maintaining homeostasis and regeneration in periodontal tissues, and development of new regeneration therapy in periodontal tissues. (Project/Area Number: 25463182 )
  • Establishment of periodontal ligament (PDL) cells derived from deciduous teeth and periodontal tissue regeneration with PDL cells. (Project/Area Number: 22592296 )
  • Analysis of pathological and/or unphysiological root resorption mechanism focused on the two types of osteoclasts (Project/Area Number: 22592274 )
  • Analysis of periodontal ligament cells derived from permanent teeth and primary teeth on tooth root resorption. (Project/Area Number: 18592239 )
  • The analysis of the network transcription regulation by the IKK・r in the tooth differentiation and development. (Project/Area Number: 17592125 )
  • RNAi-induced change in the expression of estrogen receptor α in the median preoptic nuclei of mother rats and its effects on the behavior of their offsprings. (Project/Area Number: 17390555 )
  • 修復材料の溶出成分が小児歯周組織の免疫反応に与える影響の解析 (Project/Area Number: 13877349 )
  • 乳歯歯根吸収に関与する遺伝子の同定およびその制御機構の分子生物学的解析 (Project/Area Number: 12771265 )
  • Analysis of genetic risk factors in periodontal diseses ― Effect of cellular aging on damage of cells ― (Project/Area Number: 12557178 )
  • A search for the mechanism of the stretch-induced activation of human periodontal ligament cells (Project/Area Number: 12470455 )
  • Interaction of osteoclasts and cancer cells in the process of bone invation of oral cancer (Project/Area Number: 12470432 )
  • Analysis of pathological root resorption of deciduous teeth and establishment for the treatment (Project/Area Number: 11470445 )
  • 乳歯歯根吸収に関する遺伝子の同定と吸収制御メカニズムの解明 (Project/Area Number: 10771188 )
  • Search for the bioactive molecules implicated in the regulation of human periodontal ligament cell functions (Project/Area Number: 09470464 )
  • Establishment of Human Fibroblasts deribed from Dental Pulp Tissues of Primary Teeth and Permanent Teeth, and Development of Systems of Cytotoxicity Tests for Dental Materials (Project/Area Number: 08672378 )
  • Search by Researcher Number (50274668)