Tokushima University / Educator and Researcher Directory --- Takegawa, Daisuke

Personal Web Page

https://researchmap.jp/d-takegawa (researchmap)

Field of Study

○	Life sciences [Conservative dentistry and endodontics]

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Yoko Asahi, Katsuaki Naito, Hikaru Kanda, Kazuaki Niwano, Daisuke Takegawa, Hiromichi Yumoto, Yoichiro Noiri and Mikako Hayashi : Clinical investigation of the inhibitory effects of tooth-coating materials on initial active root caries: a pilot randomized controlled trial, Medicina, Vol.60, No.1, 150, 2024. (Summary) : Caredyne ZIF-C is a novel, capsule-mixed zinc-containing prototype glass ionomer cement (GIC). Zinc ions are reported to inhibit root dentin demineralization, dentin collagen degradation, bacterial growth, acid production, and in vitro bacterial biofilm formation. However, the effectiveness of GICs against initial root caries lesions is unclear. Therefore, this study aimed to evaluate the efficacy of GICs, especially the new zinc-containing Caredyne ZIF-C GIC, as tooth-coating materials in patients with initial active root caries. : A total of 58 lesions in 47 older adults (age > 65 years) were randomly allocated to one of the following three groups: Caredyne ZIF-C, Fuji VII (a conventional GIC), and sodium fluoride (NaF). All the lesions were treated with the assigned materials without removing the infected dentin, and the rates of dental plaque attachment and coating material fall-out were evaluated after 3, 6, and 12 months. The failure rate was defined as the number of teeth that needed restoration due to caries progression. : The plaque attachment rates tended to be lower in the material-coated root surfaces than in the healthy exposed root surfaces after 3, 6, and 12 months, although the differences among the three groups were not significant. Moreover, the coating material fall-out rate tended to be lower in the Caredyne ZIF-C group than in the Fuji VII group. There was no significant difference in the failure rate among the three groups at the 12 months mark. : Though this pilot study offers a new direction for suppressing the progression of initial active root caries by controlling plaque attachment using GICs including Caredyne ZIF-C, clinical studies with a larger sample size are needed. (Keyword) Humans / Aged / Root Caries / Pilot Projects / Dental Caries / Health Status / Zinc (Link to Publication Site) ● Publication site (DOI): 10.3390/medicina60010150 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38256410 ● Search Scopus @ Elsevier (PMID): 38256410 ● Search Scopus @ Elsevier (DOI): 10.3390/medicina60010150 (DOI: 10.3390/medicina60010150, PubMed: 38256410)
2.	Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa, MIEDA Katsuhiro and Keiichi Hosaka : Caffeic Acid Phenethyl Ester Induces Vascular Endothelial Growth Factor Production and Inhibits CXCL10 Production in Human Dental Pulp Cells, Current Issues in Molecular Biology, Vol.44, No.11, 5691-5699, 2022. (Summary) The survival rate of root non-vital teeth is lower than that of vital teeth. Therefore, to preserve the dental pulp is very important. The vascular endothelial growth factor (VEGF) is the most potent angiogenic factor involved in the vitality of dental pulp including reparative dentin formation. Caffeic acid phenethyl ester (CAPE) is a physiologically active substance of propolis and has some bioactivities such as anti-inflammatory effects. However, there are no reports on the effects of CAPE on dental pulp inflammation. In this study, we investigated the effects of CAPE on VEGF and inflammatory cytokine production in human dental pulp cells (HDPCs) to apply CAPE to an ideal dental pulp protective agent. We found that CAPE induced VEGF production from HDPCs. Moreover, CAPE induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases (ERK), and stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) in HDPCs. Furthermore, CAPE inhibited C-X-C motif chemokine ligand 10 (CXCL10) production in Pam3CSK4- and tumor necrosis factor-alpha (TNF-α)-stimulated HDPCs. In conclusion, these results suggest that CAPE might be useful as a novel biological material for vital pulp therapy by exerting the effects of VEGF production and anti-inflammatory activities. (Keyword) anti-inflammatory effect / caffeic acid phenethyl ester / dental pulp cells / pulpitis / vascular endothelial growth factor / vital pulp therapy (Tokushima University Institutional Repository) ● Metadata: 117775 (Link to Publication Site) ● Publication site (DOI): 10.3390/cimb44110385 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36421669 ● Search Scopus @ Elsevier (PMID): 36421669 ● Search Scopus @ Elsevier (DOI): 10.3390/cimb44110385 (Tokushima University Institutional Repository: 117775, DOI: 10.3390/cimb44110385, PubMed: 36421669)
3.	Hitomi Kuramoto, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Tadashi Nakanishi, Daisuke Takegawa, Ayako Washio, Chiaki Kitamura and Takashi Matsuo : Caffeic acid phenethyl ester (CAPE) induces VEGF expression and production in rat odontoblastic cells, BioMed Research International, Vol.Article ID 5390720, 2019. (Summary) Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-B) transcription factor activation, and furthermore, the specific inhibitor of NF-B significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy. (Tokushima University Institutional Repository) ● Metadata: 114566 (Link to Publication Site) ● Publication site (DOI): 10.1155/2019/5390720 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31930126 ● Summary page in Scopus @ Elsevier: 2-s2.0-85077441042 (Tokushima University Institutional Repository: 114566, DOI: 10.1155/2019/5390720, PubMed: 31930126, Elsevier: Scopus)
4.	Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Hitomi Kuramoto, 鷲尾絢子, Tadashi Nakanishi, Daisuke Takegawa, 北村知昭 and Takashi Matsuo : Anti-inflammatory Effects of Catechin on Rat Odontoblastic Cells (KN-3), The Japanese Journal of Conservative Dentistry, Vol.60, No.5, 235-244, 2017. (Link to Publication Site) ● Publication site (DOI): 10.11471/shikahozon.60.235 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680498132224 ● Search Scopus @ Elsevier (DOI): 10.11471/shikahozon.60.235 (DOI: 10.11471/shikahozon.60.235, CiNii: 1390282680498132224)
5.	Yuki Hosokawa, Kouji Hirao, Hiromichi Yumoto, Ayako Washio, Tadashi Nakanishi, Daisuke Takegawa, Chiaki Kitamura and Takashi Matsuo : Functional roles of NOD1 in odontoblasts on dental pulp innate immunity, BioMed Research International, Vol.2016, 9325436, 2016. (Summary) Caries-related pathogens are first recognized by odontoblasts and induce inflammatory events that develop to pulpitis. Generally, initial sensing of microbial pathogens is mediated by pattern recognition receptors, such as Toll-like receptor and nucleotide-binding oligomerization domain (NOD); however, little is known about NODs in odontoblasts. In this study, the levels of NODs expressed in rat odontoblastic cell line, KN-3, were assessed by flow cytometry and the levels of chemokines in NOD-specific ligand-stimulated KN-3 cells were analyzed by real-time PCR and ELISA. The signal transduction pathway activated with NOD-specific ligand was assessed by blocking assay with specific inhibitors and reporter assay. In KN-3 cells, the expression level of NOD1 was stronger than that of NOD2 and the production of chemokines, such as CINC-1, CINC-2, CCL20, and MCP-1, was upregulated by stimulation with NOD1-specific ligand, but not with NOD2-specific ligand. CINC-2 and CCL20 production by stimulation with NOD1-specific ligand was reduced by p38 MAPK and AP-1 signaling inhibitors. Furthermore, the reporter assay demonstrated AP-1 activation in NOD1-specific ligand-stimulated KN-3 cells. These findings indicated that NOD1 expressed in odontoblasts functions to upregulate the chemokines expression via p38-AP-1 signaling pathway and suggested that NOD1 may play important roles in the initiation and progression of pulpitis. (Keyword) Animals / Cell Line / cytokinesis / Dental Pulp / innate immunity / Inflammation Mediators / Nod1 Signaling Adaptor Protein / Odontoblasts / Rats (Tokushima University Institutional Repository) ● Metadata: 112386 (Link to Publication Site) ● Publication site (DOI): 10.1155/2016/9325436 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27747243 ● Summary page in Scopus @ Elsevier: 2-s2.0-84991669747 (Tokushima University Institutional Repository: 112386, DOI: 10.1155/2016/9325436, PubMed: 27747243, Elsevier: Scopus)
6.	Yoshiko Yamamura, Hiromitsu Takizawa, Fumihiro Matsumoto, Yukihiro Momota, Keiko Aota, Daisuke Takegawa, 近藤智香, 山ノ井朋子, Hideyuki Takano, Kohichi Kani, 十川悠香, Fumiaki Kawano, Takashi Matsuo, Shoji Sakiyama and Masayuki Azuma : Effects of perioperative oral management in thoracoscopic lung lobectomy : Retrospective study, Oral Care, Vol.10, No.1, 106-110, 2016. (Keyword) 胸腔鏡下肺葉切除術 / 周術期口腔機能管理 / 術後合併症 / thoracoscopic lung lobectomy / Perioperative oral management / postoperative complications (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522262181026542720 (CiNii: 1522262181026542720)
7.	Tadashi Nakanishi, Kayo Mukai, Yoshitaka Hosokawa, Daisuke Takegawa and Takashi Matsuo : Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells, International Endodontic Journal, Vol.48, No.3, 277-282, 2015. (Summary) To investigate the effect of catechins on vascular endothelial growth factor (VEGF) production and cyclooxygenase-2 (COX-2) expression in human dental pulp cells (HDPC) stimulated with bacteria-derived factors or pro-inflammatory cytokines. Morphologically fibroblastic cells established from explant cultures of healthy human dental pulp tissues were used as HDPC. HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1β (IL-1β) or tumour necrosis factor-α (TNF-α). VEGF production was examined by enzyme-linked immunosorbent assay, and COX-2 expression was assessed by immunoblot. EGCG and ECG significantly reduced LPS- or PG-mediated VEGF production in the HDPC in a dose-dependent manner. EGCG also prevented IL-1β-mediated VEGF production. Although TNF-α did not enhance VEGF production in the dental pulp cells, treatment of 20 μg mL(-1) of EGCG decreased the level of VEGF. In addition, the catechins attenuated COX-2 expression induced by LPS and IL-1β. The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1β were diminished by the treatment of EGCG and ECG. These findings suggest that the catechins may be beneficial as an anti-inflammatory tool of the treatment for pulpal inflammation. (Keyword) catechin / cyclooxygenase-2 / dental pulp / vascular endothelial growth factor (Link to Publication Site) ● Publication site (DOI): 10.1111/iej.12312 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24847951 ● Search Scopus @ Elsevier (PMID): 24847951 ● Search Scopus @ Elsevier (DOI): 10.1111/iej.12312 (DOI: 10.1111/iej.12312, PubMed: 24847951)
8.	Keiko Aota, Yoshiko Yamamura, 山ノ井朋子, Daisuke Takegawa, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Fumihiro Matsumoto, Chieko Sugawara, Masami Yoshioka, Fumiaki Kawano, Takashi Matsuo and Masayuki Azuma : Current Status and Problems Regarding the Perioperative Oral Function Management in the Tokushima University Hospital, Journal of Oral Health and Biosciences, Vol.28, No.1, 29-36, 2015. (Summary) It has been shown that oral hygiene affects the onset of perioperative complications. The usefulness of perioperative oral function management aiming at the outbreak decrease in treatment complications and an early discharge was recognized. As a result, perioperative oral function management fee was founded at revision of medical service fees in Fiscal year 2012. In this clinical study, we evaluated the implementation of perioperative oral function management in Tokushima University Hospital. We examined 781 patients, including 563 patients for surgery and 218 patients for chemotherapy and radiotherapy. The mean age of patients was 58.8 ± 12.4 years old. The implementation rate of perioperative oral function management was 9.7% in the patients of surgery, and 17.4% in those of chemotherapy and radiotherapy. The highly required medical department was neurosurgery in the patients of surgery, and hematology in those of chemotherapy and radiotherapy. The mean number of tooth present was 21.3 ± 7.1 in the patients of surgery, and 19.8 ± 7.2 in those chemotherapy and radiotherapy. The rate of dental treatment was required in 40.5% of total patients who received surgery, and in 51.4% of patients who received chemotherapy and radiotherapy.The rate of patients who received denture treatment attained to 11.9% of the whole patients receiving surgery, and 13.3% of patients receiving chemotherapy and radiotherapy. It was revealed that there were many patients required potential demands in perioperative oral function management, and that there were many patients who need dental or denture treatment. We would like to develop perioperative oral function management by the interprofessional collaboration in health and social care.7月発行だが，6月号である． (Keyword) 徳島大学病院 / 周術期口腔機能管理 / チーム医療 (Tokushima University Institutional Repository) ● Metadata: 109866 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050020697877562496 (Tokushima University Institutional Repository: 109866, CiNii: 1050020697877562496)
9.	Yoshiko Yamamura, Keiko Aota, Daisuke Takegawa, 十川悠香, 近藤智香, 山ノ井朋子, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Yukihiro Momota, Junichiro Satomi, Fumiaki Kawano, Takashi Matsuo, Shinji Nagahiro and Masayuki Azuma : 徳島大学病院脳卒中センターにおける口腔管理の意義について, Journal of Oral Health and Biosciences, Vol.9, No.1, 37-41, 2015.
10.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, Yamanoi Tomoko, Kondo Chika, Shigemasa Tomioka and Masayuki Azuma : High-Wattage Pulsed Irradiation of Linearly Polarized Near-Infrared Light to Stellate Ganglion Area for Burning Mouth Syndrome, Case Reports in Dentistry, 2014. (Summary) The purpose of this study was to apply high-wattage pulsed irradiation of linearly polarized near-infrared light to the stellate ganglion area for burning mouth syndrome (BMS) and to assess the efficacy of the stellate ganglion area irradiation (SGR) on BMS using differential time-/frequency-domain parameters (D parameters). Three patients with BMS received high-wattage pulsed SGR; the response to SGR was evaluated by visual analogue scale (VAS) representing the intensity of glossalgia and D parameters used in heart rate variability analysis. High-wattage pulsed SGR significantly decreased the mean value of VAS in all cases without any adverse event such as thermal injury. D parameters mostly correlated with clinical condition of BMS. High-wattage pulsed SGR was safe and effective for the treatment of BMS; D parameters are useful for assessing efficacy of SGR on BMS. (Link to Publication Site) ● Publication site (DOI): 10.1155/2014/171657 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25386367 ● Search Scopus @ Elsevier (PMID): 25386367 ● Search Scopus @ Elsevier (DOI): 10.1155/2014/171657 (DOI: 10.1155/2014/171657, PubMed: 25386367)
11.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Modulatory roles of interferon-γ through indoleamine 2, 3-dioxygenase induction in innate immune response of dental pulp cells., Journal of Endodontics, Vol.40, No.9, 1382-1387, 2014. (Summary) Marked infiltration of inflammatory cells such as activated T cells producing interferon-γ (IFN-γ) is observed in severe pulpitis. However, the roles of IFN-γ in the innate immune response of dental pulp have not been reported. Indoleamine 2, 3-dioxygenase (IDO) is a regulator of immune responses, and the IDO expression is induced by IFN-γ in many cells whose expression in dental pulp is unknown. The purpose of this study was to determine the role of IFN-γ in the immune response through microbial pattern recognition receptors (PRRs) such as Toll-like receptors or nucleotide-binding oligomerization domain-like receptors on the production of proinflammatory cytokines such as CXCL10 and interleukin (IL)-6 and the expression of IDO in cultured human dental pulp cells (HDPCs). HDPCs were established from explant cultures of healthy pulp tissues. CXCL10 and IL-6 production was determined using enzyme-linked immunosorbent assay. Confirmation of IDO localization in dental pulp tissues was examined using immunohistochemistry. IDO expression in HDPCs was analyzed by immunoblot. IFN-γ significantly up-regulated CXCL10 and IL-6 production in the HDPCs stimulated with ligands for PRRs in a concentration-dependent manner. The expression of IDO was detected in inflamed pulp tissue. In addition, IFN-γ in combination with the PRR ligands enhanced IDO expression in HDPCs compared with IFN-γ alone. Moreover, CXCL10 production in IFN-γ-stimulated HDPCs was inhibited by an IDO inhibitor. This study showed the synergistic effects by IFN-γ on cytokine production and IDO expression in HDPCs, suggesting that IFN-γ may modulate the innate immune response of dental pulp. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.joen.2014.03.018 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25146019 ● Summary page in Scopus @ Elsevier: 2-s2.0-85027943562 (DOI: 10.1016/j.joen.2014.03.018, PubMed: 25146019, Elsevier: Scopus)
12.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, 山ノ井朋子, 近藤智香 and Masayuki Azuma : 一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-, 日本歯科人間ドック学会誌, Vol.9, 18-23, 2014.

Review, Commentary:

1.	Daisuke Takegawa, Kazuhide Yonekura, Hitomi Kuramoto, Yumika Ida, Yuki Hosokawa, Ikuko Hosokawa, Yoshitaka Hosokawa, Toshiyuki Suge, Tadashi Nakanishi and Keiichi Hosaka : Clinical Key Points of Class II Direct Composite Restoration, Journal of Oral Health and Biosciences, Vol.36, No.1, 8-12, Sep. 2023. (Keyword) dental care (Tokushima University Institutional Repository) ● Metadata: 118637 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.36.1_8 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390016062665364224 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.1_8 (Tokushima University Institutional Repository: 118637, DOI: 10.20738/johb.36.1_8, CiNii: 1390016062665364224)
2.	Daisuke Takegawa, Kouhei Kamoi and Keiichi Hosaka : デジタル技術を融合した次世代CR修復 : クオリティの高い修復を効率化するDigitally-guided Composite Injection Technique(11)バイレイヤー(2層)クリアインデックスを用いた下顎正中離開の修復, The Nippon Dental Review, Vol.82, No.11, 10-13, Nov. 2022. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520575444014801664 (CiNii: 1520575444014801664)
3.	Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi and Takashi Matsuo : The Roles of Odontoblasts in Dental Pulp Innate Immunity, Japanese Dental Science Review, Vol.54, No.3, 105-117, Aug. 2018. (Summary) Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial pathogens, especially pathogen-associated molecular patterns (PAMPs) shared by microorganisms, are mediated by pattern recognition receptors (PRRs), such as Toll-like receptor and the nucleotide-binding oligomerization domain (NOD). The innate immune responses in odontoblasts initiated by sensing oral pathogens provide host protective events, such as inflammatory reactions, to produce a variety of pro-inflammatory mediators, including chemokines and cytokines. These attract various inflammatory cells and cause antibacterial reactions, such as the production of defensins, to kill microorganisms in the proximal region of the odontoblast layer. This review focuses on innate immunity, especially cellular and molecular mechanisms regarding the sensing of PAMPs from oral pathogens by PRRs, in odontoblasts and provides information for future studies for the development of novel therapeutic strategies, including diagnosis and treatment, to prevent exceeding dental pulp inflammation and preserve the dental pulp tissues. (Tokushima University Institutional Repository) ● Metadata: 112960 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jdsr.2018.03.001 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30128058 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044379499 (Tokushima University Institutional Repository: 112960, DOI: 10.1016/j.jdsr.2018.03.001, PubMed: 30128058, Elsevier: Scopus)
4.	Takashi Matsuo, Kazumi Ozaki, Tadashi Nakanishi, Hiromichi Yumoto, Kanako Takahashi, Kouji Hirao and Daisuke Takegawa : Pulp pathosis and its diagnosis, The Journal of Japan Endodontic Association, Vol.34, No.2, 67-76, May 2013. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680166022016 (CiNii: 1390282680166022016)

Proceeding of International Conference:

1.	Yuki Hosokawa, Hiromichi Yumoto, Kouji Hirao, Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : Anti-inflammatory effects of polyphenols on rat odontoblastic cells, 95th General Session & Exhibition of the International Association for Dental Research (San Francisco), Mar. 2017.
2.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa and Takashi Matsuo : Interferon-gamma modulates the innate immune response in odontoblast-like cells, 95th General session and exhibition of the IADR, Mar. 2017.
3.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa and Takashi Matsuo : Effect of interleukin-17A on CCL20 production from odontoblast-like cells, 95th General session and exhibition of the IADR, Mar. 2017.
4.	Tadashi Nakanishi, Daisuke Takegawa, Hiromichi Yumoto, Kouji Hirao and Takashi Matsuo : Interleukin-17 Regulates Inflammatory Mediator Expression in IL-1beta-stimulated Dental Pulp Cells, 93th General Session & Exhibition of the International Association for Dental Research, Boston (USA), Mar. 2015.
5.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Prostaglandin F2a Regulates Cytokine Expression in Dental Pulp Cells, 91th General Session & Exhibition of the IADR, Seattle, USA, Mar. 2013.
6.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : Interferon-g modulates the innate immune response of dental pulp cells, 91th General Session & Exhibition of the IADR, Seattle, USA, Mar. 2013.

Proceeding of Domestic Conference:

1.	朝日陽子, 内藤克昭, 神田ひかる, 庭野和明, Daisuke Takegawa, Hiromichi Yumoto, 野杁由一郎 and 林美加子 : 初期活動性根面う蝕患者におけるケアダインZIF-Cのバイオフィルム抑制効果に関する臨床評価, 日本歯科保存学会 2023年度秋季学術大会(第159回), Nov. 2023.
2.	Kaho Yumoto, Daisuke Takegawa, Yoshitaka Suzuki, Kouhei Kamoi, Kazuo Okura, Aya Ozawa, SHIBAGAKI Akari, 富永賢, Keiichi Hosaka and Yoshizo Matsuka : デジタル技術を用いて製作したミュージックスプリントの内面適合性に関する検討(第一報), 日本演奏芸術医学研究会, Jul. 2023.
3.	Kaho Yumoto, Yoshitaka Suzuki, Daisuke Takegawa, Toshinori Okawa, Kouhei Kamoi, Aya Ozawa, SHIBAGAKI Akari, SHINKAI Mizuki, TANIWAKI Tatsuya, 富永賢, Keiichi Hosaka and Yoshizo Matsuka : デジタル技術を利用したミュージックスプリントの内面適合性に関する評価法の検討, Shikoku Dental Research, Jul. 2023.
4.	MIEDA Katsuhiro, Tadashi Nakanishi, Hitomi Kuramoto, Yoshitaka Hosokawa, Ikuko Hosokawa, Daisuke Takegawa and Keiichi Hosaka : Sudachitinがヒト歯髄細胞の炎症メディエーター発現に与える影響, 日本歯科保存学会 2023年度春季学術大会(第158回), Jun. 2023.
5.	Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa, MIEDA Katsuhiro and Keiichi Hosaka : Caffeic acid phenethyl ester (CAPE) がマウス骨芽細胞様細胞の組織修復関連因子発現に与える影響, 日本歯科保存学会 2023年度春季学術大会(第158回), Jun. 2023.
6.	Kaho Yumoto, Yoshitaka Suzuki, Kouhei Kamoi, Kazuo Okura, Aya Ozawa, SHINKAI Mizuki, TANIWAKI Tatsuya, Toshinori Okawa, Daisuke Takegawa, Masamitsu Ohshima and Yoshizo Matsuka : デジタルワークフローを用いたミュージックスプリント内面のデザインに関する予備検討, The Journal of the Japan Prosthodontic Society, May 2023.
7.	三枝克啓, Tadashi Nakanishi, Hitomi Kuramoto, Daisuke Takegawa and Keiichi Hosaka : Interleukin-22 がヒト歯髄細胞の炎症性メディエーター発現に及ぼす影響, 第4回象牙質歯髄治療学会学術大会, May 2023.
8.	Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa, Yuki Hosokawa, Katsuhiro Mieda and Keiichi Hosaka : The effects of Caffeic acid phenethyl ester (CAPE) on VEGF production in dental pulp cells, 日本歯科保存学会2021年度秋季学術大会(第155回), Oct. 2021.
9.	Hitomi Kuramoto, Kouji Hirao, Yuki Hosokawa, Daisuke Takegawa, Hiromichi Yumoto and Tadashi Nakanishi : ラット象牙芽細胞(KN-3)におけるVEGFの石灰化誘導作用, 日本歯科保存学会 2019年度秋季学術大会(第151回) (福岡), Nov. 2019.
10.	Daisuke Takegawa, Tadashi Nakanishi, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Hitomi Kuramoto and Takashi Matsuo : Effects of interferon-γ on innate host responses in cultured odontoblast-like cells stimulated with NOD ligands, 第150回日本歯科保存学会 2019年度春季学術大会, Jun. 2019.
11.	Hitomi Kuramoto, Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : Caffeic Acid Phenetyl Ester (CAPE)の象牙芽細胞と骨芽細胞におけるVEGF産生誘導機序の解析, 第148回日本歯科保存学会春季学術大会, Jun. 2018.
12.	Hitomi Kuramoto, Hiromichi Yumoto, Kouji Hirao, 細川由樹, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : Caffeic Acid Phenethyl Ester (CAPE)のラット象牙芽細胞(KN-3)におけるVEGF産生に与える影響, 日本歯科保存学会2017年度春季学術大会(第146回), Jun. 2017.
13.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, 細川由樹 and Takashi Matsuo : Interleukin-17がラット象牙芽細胞様細胞(KN-3)のCCL20産生に及ぼす影響, 日本歯科保存学会 2015年度秋季学術大会(第143回), Nov. 2015.
14.	細川由樹, Hiromichi Yumoto, Kouji Hirao, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : 象牙芽細胞が有するMincleを介した視細胞認識機構とその歯髄炎症反応における役割, 日本歯科保存学会 2015年度秋季学術大会(第143回), Nov. 2015.
15.	Keiko Aota, 山ノ井朋子, 近藤智香, Hideyuki Takano, Daisuke Takegawa, Yoshiko Yamamura, Kohichi Kani, Yukihiro Momota, Fumihiro Matsumoto and Masayuki Azuma : 進行期肺がん患者の口腔管理∼ゾレドロン酸，デノスマブ投与前の歯科治療を考える∼, 第12回口腔ケア学会総会, Jun. 2015.
16.	Kouji Hirao, Hiromichi Yumoto, 細川由樹, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : ラット象牙芽細胞(KN-3)の自然免疫反応におけるシグナル伝達経路の解析, 日本歯科保存学会2015年度春季学術大会(第142回), Jun. 2015.
17.	細川由樹, Hiromichi Yumoto, Kouji Hirao, Tadashi Nakanishi, Daisuke Takegawa and Takashi Matsuo : ラット象牙芽細胞(KN-3)に対するカテキンとカフェイン酸の抗炎症作用, 日本歯科保存学会2015年度春季学術大会(第142回), Jun. 2015.
18.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, 山ノ井朋子, 近藤智香 and Masayuki Azuma : 新規口腔ケア製品「ペプチサルシリーズ」の使用感に関する調査, 第12回日本口腔ケア学会, Jun. 2015.
19.	Keiko Aota, Yoshiko Yamamura, 山ノ井朋子, 近藤智香, Daisuke Takegawa, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, 松本文博 and Masayuki Azuma : Sjögren 症候群唾液腺における IP-10 の役割, 第51回日本口腔組織培養学会学術大会, Nov. 2014.
20.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto and Takashi Matsuo : Interleukin-17がヒト歯髄線維芽細胞の炎症メディエーター発現に及ぼす影響, 日本歯科保存学会2014年度秋季学術大会(第141回), Oct. 2014.
21.	Yoshiko Yamamura, Hiromitsu Takizawa, Fumihiro Matsumoto, Yukihiro Momota, Keiko Aota, Daisuke Takegawa, Kohichi Kani, Hideyuki Takano, 山ノ井朋子, 近藤智香, 金川裕子, 高瀬奈緒, Yuka Sogawa and Masayuki Azuma : 肺癌患者における周術期口腔機能管理の有用性について-術後合併症の観点より-, 第62回NPO法人日本口腔科学会中国・四国地方部会, Oct. 2014.
22.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Yoshiko Yamamura, Daisuke Takegawa, 山ノ井朋子, 近藤智香, 金川裕子 and Masayuki Azuma : 徳島大学病院口腔内科組織改編前後の患者動向について, 第24回日本口腔内科学会, Sep. 2014.
23.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Yoshiko Yamamura, Daisuke Takegawa, 山ノ井朋子, 近藤智香, 金川裕子 and Masayuki Azuma : 徳島大学病院口腔内科発足前後の患者動向について, 第45回四国歯学会例会・第33回四国歯学会総会, Jun. 2014.
24.	Kouji Hirao, Hiromichi Yumoto, Tadashi Nakanishi, Chihiro Shinohara, Kanako Takahashi, Daisuke Takegawa, 細川由樹 and Takashi Matsuo : ラット象牙芽細胞様細胞(KN3)における細菌関連病原因子刺激に対する自然免疫反応の解析, 日本歯科保存学会2014年度春季学術大会(第140回), Jun. 2014.
25.	Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, Kanako Takahashi and Takashi Matsuo : prostaglandin F2aは歯髄細胞における炎症性メディエーター発現を調節する, 第136回日本歯科保存学会春季学術大会, Jun. 2012.

Et cetera, Workshop:

1.	Junichiro Satomi, Yoshiko Yamamura, Keiko Aota, Daisuke Takegawa, Fumihiro Matsumoto, Yuka Sogawa and Masayuki Azuma : 徳島大学病院脳卒中センターにおける口腔管理の意義について, 第17回徳島脳卒中研究会, Feb. 2015.
2.	Kohichi Kani, Yukihiro Momota, Hideyuki Takano, Keiko Aota, Fumihiro Matsumoto, Yoshiko Yamamura, Daisuke Takegawa, 山ノ井朋子, 近藤智香, 金川裕子 and Masayuki Azuma : がん治療における周術期口腔機能管理の現状と課題, 徳島大学病院Cancer Board, Sep. 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

デジタル技術を活用したミュージックスプリントの革新：木管楽器奏者の口腔問題対策 (Project/Area Number: 24K03557 )
Elucidation of odontoblasts calcification and innate immune response in early pulpitis (Project/Area Number: 17K11709 )
Educidation of the innate immune response of odontoblasts against bacteria-derived factor in the pathogenesis of pulpitis (Project/Area Number: 15K20406 )
Elucidation of the innate immune response of dental pulp cells against bacteria-derived factor in the pathogenesis of pulpitis (Project/Area Number: 25861802 )
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Assistant Professor : Takegawa, Daisuke

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)