Tokushima University / Educator and Researcher Directory --- Iwawaki, Yuki

Field of Study

Subject of Study

Book / Paper

Book:

1.	Tetsuo Ichikawa, Takaharu Goto and Yuki Iwawaki : Part 5 力を診査，診断する．生体に危険な力を理解し，治療に生かす, Ishiyaku Publishers,Inc., Jan. 2024.
2.	Yuki Iwawaki and 市川哲雄 : らくらくお口のケア義歯ケア辞典第1章 1唾液と義歯, 2義歯装着による口腔内環境の変化, 4口腔内微生物, 2018.

Academic Paper (Judged Full Paper):

1.	Adityakrisna Putra Yoshi Wigianto, Megumi Watanabe, Yuki Iwawaki, Takaharu Goto, Tamaki Otsuki and Tetsuo Ichikawa : Antimicrobial Efficacy of a Portable UV-C-Based Coating Activation Device against Candida albicans Biofilm and SARS-CoV-2 as an Additional Feature: An In Vitro Study., Hygiene, Vol.4, No.1, 93-102, 2024. (Link to Publication Site) ● Publication site (DOI): 10.3390/hygiene4010006 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3390/hygiene4010006 (DOI: 10.3390/hygiene4010006)
2.	Adityakrisna Putra Yoshi Wigianto, Yuichi Ishida, Yuki Iwawaki, Takaharu Goto, Megumi Watanabe, Kazumitsu Sekine, Kenichi Hamada, Keiji Murakami, Hideki Fujii and Tetsuo Ichikawa : 2-methacryloyloxyethyl phosphorylcholine polymer treatment prevents Candida albicans biofilm formation on acrylic resin, Journal of Prosthodontic Research, Vol.67, No.3, 384-391, 2022. (Summary) We aimed to evaluate the effectiveness of photoreactive 2-methacryloyloxyethyl phosphorylcholine (MPC) in inhibiting Candida albicans biofilm formation on polymethyl methacrylate (PMMA) and assess its mechanism and need for re-application by evaluating its interaction with salivary mucin and durability during temperature changes. PMMA discs were used as specimens. The MPC coating was applied using the spray and cure technique for the treatment groups, whereas no coating was applied to the control. The MPC treatment (MT) groups were further differentiated based on the number of thermal cycles involved (0, 1000, 2500, and 5000). The optical density was measured to assess mucin adsorption (MA). Contact angle (CA) was calculated to evaluate surface hydrophilicity. The presence of MPC components on the PMMA surface was assessed using X-ray photoelectron spectroscopy (XPS). C. albicans biofilms were evaluated qualitatively (scanning electron microscope images) and quantitatively (colony-forming units (CFUs)). Statistical analysis was conducted using two-way analysis of variance and Tukey's multiple comparison test. MA rate and CA increased significantly in the MT groups, which exhibited significantly fewer CFUs and thinner biofilms than those of the control group. Based on the XPS, MA, and CFU evaluations, the durability and efficacy of the MPC coating were considered stable up to 2500 thermal cycles. Additionally, a significant interaction was observed between mucin concentration and MPC efficacy. The photoreactive MPC coating, which was resistant to temperature changes for approximately 3 months, effectively prevented C. albicans biofilm formation by modifying surface hydrophilicity and increasing mucin adsorption. (Keyword) Candida albicans / Acrylic Resins / Polymers / Polymethyl Methacrylate / Surface Properties / Biofilms / Mucins (Tokushima University Institutional Repository) ● Metadata: 119402 (Link to Publication Site) ● Publication site (DOI): 10.2186/jpr.JPR_D_22_00102 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36288959 ● Summary page in Scopus @ Elsevier: 2-s2.0-85166383313 (Tokushima University Institutional Repository: 119402, DOI: 10.2186/jpr.JPR_D_22_00102, PubMed: 36288959, Elsevier: Scopus)
3.	Wigianto Yoshi Putra Adityakrisna, Takaharu Goto, Yuki Iwawaki, Yuichi Ishida, Megumi Watanabe and Tetsuo Ichikawa : Treatment outcomes of implant-assisted removable partial denture with distal extension based on the Kennedy classification and attachment type: a systematic review, International Journal of Implant Dentistry, Vol.7, No.1, 111, 2021. (Summary) Implant-assisted removable partial dentures (IARPDs) have recently become popular, but little information is available on the treatment outcomes based on the Kennedy classification and attachment types. The objective of this review was to evaluate the treatment outcomes of IARPD delivered for distal extension edentulous areas based on the differences in the Kennedy classification and attachment type. English-language clinical studies on IARPD published between January 1980 and February 2020 were collected from MEDLINE (via PubMed), the Cochrane Library (via the Cochrane Central Register of Controlled Trials), Scopus online database, and manual searching. Two reviewers selected the articles based on pre-determined inclusion and exclusion criteria, followed by data extraction and analysis. Eighty-one studies were selected after evaluating the titles and abstracts of 2410 papers. Nineteen studies were finally included after the perusal of the full text. Fourteen studies focused on Class I, 4 studies investigated both Class I and II, and only 1 study was conducted on Kennedy's class II. Eight types of attachments were reported. The ball attachment was the most frequently used attachment, which was employed in 8 of the included studies. The implant survival rate ranged from 91 to 100%. The reported marginal bone loss ranged from 0.3 mm to 2.30 mm. The patient satisfaction was higher with IARPD than with conventional RPDs or that before treatment. The results of prosthetic complications were heterogeneous and inconclusive. IARPD exhibited favorable clinical outcomes when used as a replacement for distal extension edentulous areas. The comparison between the clinical outcomes of Kennedy's class I and II was inconclusive owing to the lack of studies focusing on Kennedy Class II alone. The stud attachment was the most commonly used type in IARPDs. Overall, the different attachment systems did not influence the implant survival rate and patient satisfaction. Further high-quality studies are needed to investigate the attachment systems used in IARPD. (Keyword) Dental Implants / Dental Prosthesis, Implant-Supported / Denture, Partial, Removable / Humans / Patient Satisfaction / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1186/s40729-021-00394-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34773513 ● Search Scopus @ Elsevier (PMID): 34773513 ● Search Scopus @ Elsevier (DOI): 10.1186/s40729-021-00394-z (DOI: 10.1186/s40729-021-00394-z, PubMed: 34773513)
4.	Keiko Fujimoto, Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto, Kan Nagao and Tetsuo Ichikawa : Objective Assessment of Poor Oral Hygiene Using the ATP Swab Test in the Elderly, Japanese Journal of Gerodontology, Vol.36, No.1, 44-52, 2021. (Summary) <p> Purpose:The purpose of this study was to evaluate the assessment of poor oral hygiene using the ATP swab test.</p><p> Method:A total of 102 consecutive elderly outpatients aged ≥65 years who visited for maintenance were enrolled between October 2019 and April 2020. The evaluation of poor oral hygiene included measurements of:Tongue Coating Index(TCI), number of bacteria by a rapid oral bacterial detection device(Bacterial Counter DU-AA01NP-H;Panasonic Health Care, Japan), and amount of ATP+AMP by the ATP swab test(Lumitester;Kikkoman, Japan). The specimens were a gargle solution rinsed with 10 mL of water for 5 seconds as soon as the patients came to the hospital or a cotton swab wiped on the tongue dorsum. The subjective assessment of hygiene of the oral mucosa and dentures was rated on a 5-point scale.</p><p> Results:In the assessment of tongue dorsum hygiene, the number of bacteria and the amount of ATP+AMP were significantly correlated with TCI. There was also a significant correlation between the number of bacteria and the amount of ATP+AMP.</p><p> Conclusion:The results of this study suggested that the ATP swab test might be used to objectively assess overall poor oral hygiene, including food residues.</p> (Keyword) elderly / poor oral hygiene / ATP swab test / bacterial counts / Tongue Coating Index (Link to Publication Site) ● Publication site (DOI): 10.11259/jsg.36.44 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390007282526004352 ● Search Scopus @ Elsevier (DOI): 10.11259/jsg.36.44 (DOI: 10.11259/jsg.36.44, CiNii: 1390007282526004352)
5.	Takaharu Goto, Takahiro Kishimoto, Yuki Iwawaki, Keiko Fujimoto, Yuichi Ishida, Megumi Watanabe, Kan Nagao and Tetsuo Ichikawa : Reliability of screening methods to diagnose oral dryness and evaluate saliva secretion, Dentistry Journal, Vol.8, No.3, 2020. (Tokushima University Institutional Repository) ● Metadata: 115896 (Link to Publication Site) ● Publication site (DOI): 10.3390/dj8030102 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85092017329 (Tokushima University Institutional Repository: 115896, DOI: 10.3390/dj8030102, Elsevier: Scopus)
6.	Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto, Norikazu Minami, Keiko Fujimoto and Tetsuo Ichikawa : アルコール含有義歯安定剤であるホームリライナーが呼気中アルコール濃度へ与える影響の評価, Annals of Japan Prosthodontic Society, Vol.11, No.4, 376-382, 2019. (Link to Publication Site) ● Publication site (DOI): 10.2186/ajps.11.376 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001277378697088 ● Search Scopus @ Elsevier (DOI): 10.2186/ajps.11.376 (DOI: 10.2186/ajps.11.376, CiNii: 1390001277378697088)
7.	Yuki Iwawaki, Takashi Matsuda, Kosuke Kurahashi, Tsuyoshi Honda, Takaharu Goto and Tetsuo Ichikawa : Effect of the temperature of water on ultrasonic denture cleaning, Journal of Oral Science, Vol.61, No.1, 140-145, 2019. (Summary) Denture plaque is a biofilm composed of various microorganisms aggregated with saliva. Various denture cleansers and cleaning apparatuses have been developed and studied. However, the optimum water temperature for denture cleaning is unknown. Therefore, the present study investigated the effects of water temperature during ultrasonic denture cleaning. In vitro, resin disks with artificial Candida albicans biofilm were pressed onto Candida GE media after ultrasonic cleaning with water at different temperatures for 5 min. The media were subsequently cultured at 37°C for 24 h. The colonies formed were observed and colony areas were quantified using ImageJ software (US National Institutes of Health, Bethesda, MD, USA). In situ, the bacterial count and degree of cleanliness on the tissue surface of maxillary dentures were measured before and after ultrasonic cleaning with water at different temperatures for 5 min. Changes in bacterial counts and cleanliness were calculated for each temperature. The ratio of the area occupied by bacterial colonies in vitro and reduction rates in situ after cleaning with warm water were markedly less than those observed after cleaning with cold water. Therefore, ultrasonic denture cleaning with warm water is more effective. (Keyword) Bacteria / Biofilms / Candida albicans / Colony Count, Microbial / Culture Media / Dentures / Disinfection / Hot Temperature / Ultrasonic Waves / Water (Link to Publication Site) ● Publication site (DOI): 10.2334/josnusd.17-0387 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30918210 ● Summary page in Scopus @ Elsevier: 2-s2.0-85063941566 (DOI: 10.2334/josnusd.17-0387, PubMed: 30918210, Elsevier: Scopus)
8.	Yuki Iwawaki, Muraoka Yuki, Higashiyama Hiroaki, Takahiro Kishimoto, Liu Lipei, Takaharu Goto and Tetsuo Ichikawa : Comparison between two assessment tests for oral hygiene: adenosine triphosphate + adenosine monophosphate swab test and bacteria number counting by dielectrophoretic impedance measurement, Dentistry Journal, Vol.7, No.1, 10, 2019. (Tokushima University Institutional Repository) ● Metadata: 115081 (Link to Publication Site) ● Publication site (DOI): 10.3390/dj7010010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30717111 ● Summary page in Scopus @ Elsevier: 2-s2.0-85064059150 (Tokushima University Institutional Repository: 115081, DOI: 10.3390/dj7010010, PubMed: 30717111, Elsevier: Scopus)
9.	Kohsuke Kurahashi, Yuki Iwawaki, Takashi Matsuda, Takaharu Goto, 石田雄一, Teruaki Ito and Tetsuo Ichikawa : Duplicate complete dentures made by general digital devices: Evaluation of material properties and clinical trial, Annals of Japan Prosthodontic Society, Vol.9, No.4, 357-364, 2017. (Summary) <p><b>Purpose:</b> The purpose of this study was to investigate the validity of the process of duplicating complete dentures using general digital devices through the following tests: cytotoxicity test of materials used, adhesion test of materials to a silicone impression material and a self-curing resin, and questionnaires to operators on duplicate dentures in clinical situations.</p><p><b>Methods: </b>The cell viability of mouse fibroblast-like cells in acrylonitrile- butadiene-styrene (ABS) and polylactic acid (PLA) were evaluated as a cytotoxicity test. The tensile strength between the silicone impression material/self-curing resin and ABS/PLA specimen was measured as adhesive strength using a universal testing machine. Six practitioners who used duplicate PLA complete dentures in 7 patients were asked to evaluate the duplicate denture using the original questionnaire.</p><p><b>Results:</b> The cytotoxicity test showed that the cell viabilities in ABS and PLA were similar to that in acrylic resin at the cell culture times of 24, 48 and 72 hours. The adhesion test showed that the adhesive strength between the ABS/PLA and silicone impression material was significantly lower than that between the conventional self-curing resin and silicone impression material. Although the adhesive strength between the PLA and self-curing resin was low, there was no significant difference between the ABS and self-curing resin. The results of the questionnaire showed that the duplicate denture made of PLA would be of similar value compared to the conventional duplicate denture made of acrylic resin.</p><p><b>Conclusions:</b> The present study suggests that the duplicate complete dentures made by our proposed digital process are clinically effective.</p> (Keyword) CAD/CAM / Duplicate denture / Complete denture / 3-dimensional printer / Digital dentistry (Tokushima University Institutional Repository) ● Metadata: 111854 (Link to Publication Site) ● Publication site (DOI): 10.2186/ajps.9.357 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205300772736 ● Search Scopus @ Elsevier (DOI): 10.2186/ajps.9.357 (Tokushima University Institutional Repository: 111854, DOI: 10.2186/ajps.9.357, CiNii: 1390001205300772736)
10.	Yuki Iwawaki, Noriko Mizusawa, Takeo Iwata, Nobuaki Higaki, Takaharu Goto, Megumi Watanabe, Yoritoki Tomotake, Tetsuo Ichikawa and Katsuhiko Yoshimoto : MiR-494-3p induced by compressive force inhibits cell proliferation in MC3T3-E1 cells., Journal of Bioscience and Bioengineering, Vol.120, No.4, 456-462, 2015. (Summary) Mechanical stimuli regulate fundamental cell processes such as proliferation, differentiation, and morphogenesis. We attempted to identify microRNA (miRNA) whose expression is changed during compressive treatment in MC3T3-E1, a pre-osteoblastic cell line. Microarray analysis followed by reverse transcription-quantitative polymerase chain reaction revealed that compressive force at 294 Pa for 24 h in MC3T3-E1 cells increased levels of miR-494-3p, miR-146a-5p, miR-210-3p, and miR-1247-3p. Among these miRNAs, miR-494-3p was found to inhibit cell proliferation in MC3T3-E1 cells. Furthermore, cells subjected to compressive force showed slower cell growth compared with control cells. Levels of mRNA for fibroblast growth factor receptor 2 (FGFR2) and Rho-associated coiled-coil kinase 1 (ROCK1), which were predicted to be targets of miR-494-3p, were decreased by compressive force or overexpression of miR-494-3p mimics in MC3T3-E1 cells. Furthermore, binding sites of miR-494-3p within 3'-untranslated regions of Fgfr2 and Rock1 were determined using luciferase reporter assay. In conclusion, compressive force affected expressions of several miRNAs including miR-494-3p in MC3T3-E1 cells. Compressive force might inhibit cell proliferation in osteoblasts by up-regulating miR-494-3p followed by FGFR2 and ROCK1 gene repressions. (Keyword) 3' Untranslated Regions / Cell Line / Cell Proliferation / Down-Regulation / Gene Expression Regulation / Humans / Luciferases / MicroRNAs / Oligonucleotide Array Sequence Analysis / Osteoblasts / RNA, Messenger / Receptor, Fibroblast Growth Factor, Type 2 / Reverse Transcriptase Polymerase Chain Reaction / Stress, Mechanical / Up-Regulation / rho-Associated Kinases (Tokushima University Institutional Repository) ● Metadata: 109479 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jbiosc.2015.02.006 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25795570 ● Summary page in Scopus @ Elsevier: 2-s2.0-84938332268 (Tokushima University Institutional Repository: 109479, DOI: 10.1016/j.jbiosc.2015.02.006, PubMed: 25795570, Elsevier: Scopus)
11.	Yoritoki Tomotake, Yuki Iwawaki, Takaharu Goto, 西中英伸 and Tetsuo Ichikawa : インプラント上部構造における前装材破折と主機能部位との関連について, Journal of Japanese Society of Oral Implantology, Vol.28, No.3, 326-333, 2015. (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.28.326 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205510925824 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.28.326 (DOI: 10.11237/jsoi.28.326, CiNii: 1390001205510925824)
12.	Tetsuo Ichikawa, Takaharu Goto, Yuki Iwawaki, 檜垣宣明 and Yoshihito Naitou : 補綴装置および歯の延命のために(Part 6) 力のコントロール力を受ける生体側の観点から, Annals of Japan Prosthodontic Society, Vol.7, No.4, 357-362, 2015. (Link to Publication Site) ● Publication site (DOI): 10.2186/ajps.7.357 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2186/ajps.7.357 (DOI: 10.2186/ajps.7.357)
13.	Hideki Suito, Yuki Iwawaki, Takaharu Goto, Yoritoki Tomotake and Tetsuo Ichikawa : Oral factors affecting titanium elution and corrosion: an in vitro study using simulated body fluid., PLoS ONE, Vol.8, No.6, e66052, 2013. (Summary) Ti, which is biocompatible and resistant to corrosion, is widely used for dental implants, particularly in patients allergic to other materials. However, numerous studies have reported on Ti allergy and the in vitro corrosion of Ti. This study investigated the conditions that promote the elution of Ti ions from Ti implants. Specimens of commercially pure Ti, pure nickel, a magnetic alloy, and a gold alloy were tested. Each specimen was immersed in a simulated body fluid (SBF) whose pH value was controlled (2.0, 3.0, 5.0, 7.4, and 9.0) using either hydrochloric or lactic acid. The parameters investigated were the following: duration of immersion, pH of the SBF, contact with a dissimilar metal, and mechanical stimulus. The amounts of Ti ions eluted were measured using a polarized Zeeman atomic absorption spectrophotometer. Eluted Ti ions were detected after 24 h (pH of 2.0 and 3.0) and after 48 h (pH of 9.0). However, even after 4 weeks, eluted Ti ions were not detected in SBF solutions with pH values of 5.0 and 7.4. Ti elution was affected by immersion time, pH, acid type, mechanical stimulus, and contact with a dissimilar metal. Elution of Ti ions in a Candida albicans culture medium was observed after 72 h. Elution of Ti ions in the SBF was influenced by its pH and by crevice corrosion. The results of this study elucidate the conditions that lead to the elution of Ti ions in humans, which results in implant corrosion and Ti allergy. (Keyword) Body Fluids / Candida albicans / Corrosion / Dental Alloys / Humans / Hydrogen-Ion Concentration / Ions / Solutions / Stress, Mechanical / titanium (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0066052 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23762461 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878805527 (DOI: 10.1371/journal.pone.0066052, PubMed: 23762461, Elsevier: Scopus)
14.	Yoshihito Naitou, Ashrin N. Meinar, Yuki Iwawaki, Toshiya Kashiwabara, Takaharu Goto, Teruaki Ito, Tetsuro Sakuma and Tetsuo Ichikawa : Recording of individual identification information on dental prostheses using fluorescent material and ultraviolet light, The International Journal of Prosthodontics, Vol.26, No.2, 172-174, 2013. (Summary) The placement of individual identification on a prosthesis is very important for forensic dentistry and traceability. This article describes the unique naming/labeling of dentures with information for individual identification using a method in which information is invisible under natural light but visible under ultraviolet light-emitting diode/black light exposure. The use of laser beam machining with this method will enable the recording of a large amount of information. (Keyword) Acrylic Resins / Composite Resins / Dental Materials / Denture Bases / Denture Design / Denture Identification Marking / Fluorescent Dyes / Forensic Dentistry / Humans / Image Processing, Computer-Assisted / Lasers / surface properties / Ultraviolet Rays (Link to Publication Site) ● Publication site (DOI): 10.11607/ijp.3350 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23476913 ● Summary page in Scopus @ Elsevier: 2-s2.0-84879189814 (DOI: 10.11607/ijp.3350, PubMed: 23476913, Elsevier: Scopus)
15.	水頭英樹, 後藤崇晴, Yuki Iwawaki, 友竹偉則 and 市川哲雄 : 磁性アタッチメントを用いたミニインプラントオーバーデンチャーにおける力学解析, Journal of Japanese Society of Oral Implantology, Vol.26, No.4, 660-667, 2013.

Review, Commentary:

1.	Keiko Fujimoto, Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto and Tetsuo Ichikawa : 高齢者の義歯を含む口腔衛生状態の評価 ―ATP 拭き取り検査による評価―, 日本義歯ケア学会誌, Vol.15, No.1, 1-8, Dec. 2023.
2.	Takahiro Kishimoto, Takaharu Goto, Takashi Matsuda, Yuki Iwawaki and Tetsuo Ichikawa : Application of artificial intelligence in the dental field: A literature review., Journal of Prosthodontic Research, Vol.66, No.1, 19-28, Jan. 2022. (Summary) Application of AI in the dental field has progressed; however, the criteria for evaluating the efficacy of AI have not been clarified. It is necessary to obtain better quality data for machine learning to achieve the effective diagnosis of lesions and suitable treatment planning. (Tokushima University Institutional Repository) ● Metadata: 117143 (Link to Publication Site) ● Publication site (DOI): 10.2186/jpr.JPR_D_20_00139 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33441504 ● Search Scopus @ Elsevier (PMID): 33441504 ● Search Scopus @ Elsevier (DOI): 10.2186/jpr.JPR_D_20_00139 (Tokushima University Institutional Repository: 117143, DOI: 10.2186/jpr.JPR_D_20_00139, PubMed: 33441504)
3.	Tetsuo Ichikawa, Megumi Watanabe, Yuichi Ishida and Yuki Iwawaki : インプラント治療に関わる高齢者の諸問題とその対応インプラント治療における多(他)職種との連携を見据えて, 日本歯科先端技術研究所学術会誌, Vol.27, No.1, 14-21, Feb. 2021. (Summary) 高齢，要介護を見据えてのインプラントの治療計画とその対応，超高齢化が進むなかでインプラント治療において考えるべきことについて概説した．インプラントの設計において，基本的にはケアがしやすく，修理がしやすい構造にすることが挙げられる．また，これまでは避けるべき治療方法，対応方法とされてきた方法，たとえば残存歯との連結や有床義歯の支台歯として使用することなども，終末期に向かうなかではその選択を否定できないか好ましい選択肢となる場合も想定される．インプラントの上部構造を患者の身体的，精神的，社会的状況に合わせ徐々に修正，対応して行くことが求められる． (Keyword) 加齢筋骨格系疾患歯科インプラント歯科補綴死亡性因子無歯顎-部分(治療,外科的療法) 高齢者歯科医療インプラント支持歯科補綴物 *多機関医療協力システム費用効果分析 BMI 自立生活アドバンスケア計画訪問歯科診療筋肉減少症歩行速度フレイル高齢化社会メインテナンス(歯科) ロコモティブシンドローム地域包括ケアシステムヒト高齢者(65∼79) 歯学
4.	Yuki Iwawaki and Tetsuo Ichikawa : 義歯安定剤中に含有されるアルコールの呼気検査へ影響, The Nippon Dental Review, Vol.78, No.10, 24-26, Sep. 2018.
5.	後藤崇晴, Yuki Iwawaki and 市川哲雄 : 力学的刺激に対する支持組織の負担様相: 受圧の要素の観点から., 歯界展望別冊「補綴装置および歯の延命のための最新治療指針」, 144-151, 2016.
6.	後藤崇晴, Yuki Iwawaki, 渡邉恵, 永尾寛 and 市川哲雄 : 補綴装置による個人認証システムに関する文献的考察, Journal of Oral Health and Biosciences, Vol.27, No.1, 63--69, 2015.

Proceeding of International Conference:

1.	Takaharu Goto, Tsukasa Hihara, Tagami Yoshihiro, Yuki Iwawaki, Kan Nagao and Tetsuo Ichikawa : Investigation with questionnaires on symptoms of physical frailty and eating behaviors, 11th Biennial Congress of Asian Academy of Prosthodontics, Kuala Lumpur, Malaysia, Sep. 2018.
2.	Takaharu Goto, Hihara Tsukasa, Kishimoto Takahiro, Takashi Matsuda, Yuki Iwawaki, Kan Nagao and Tetsuo Ichikawa : Investigation with questionnaires on symptoms of oral frailty and eating behaviors: Importance of chewing, Biennial Joint Congress of JPS-CPS-KAP, Wenzhou, China, Oct. 2017.
3.	Tetsuo Ichikawa, Higaki Nobuaki, Takaharu Goto, Kishimoto Takahiro, Yuki Iwawaki, Takashi Matsuda, Ishida Yuichi and Watanabe Megumi : A comparison of the occlusal force-sustaining ability of natural and dental implant patients during a sensory integration task, Biennial Joint Congress of JPS-CPS-KAP, Wenzhou, China, Oct. 2017.
4.	Higaki Nobuaki, Goto Takaharu, Yuki Iwawaki, Nagao Kan and Ichikawa Tetsuo : Brain function analysis on modulation ability of occlusal force and sensory integration: Evaluations using wearable near-infrared spectroscopy, The 16th Biennial Meeting of International College of Prosthodontists, 2015.
5.	Yuki Iwawaki, Mizusawa Noriko, Tomotake Yoritoki, Ichikawa Tetsuo and Yoshimoto Katsuhiko : Mechanical stress - responsive micro-RNA, The 3rd ASEAN plus and TOKUSHIMA Joint International Conference on ``Strategic Achievement of Oral Sciences and Promotion of Quality of Life'', 2014.
6.	Higaki Nobuaki, Goto Takaharu, Yuki Iwawaki, Nagao Kan and Ichikawa Tetsuo : Efficiency of oral stimulations on brain function activities: Evaluations using wearable near-infrared spectroscopy, The 15th Biennial Meeting of the International College of Prosthodontists, 2013.
7.	Yuki Iwawaki, Yoshihito Naitou, Li Jing, Kan Nagao and Tetsuo Ichikawa : The long-term change in properties of the anti-microbiological tissue conditioner containing Juncus powder, The 7th Biennial Meeting of AAP, Shanghai, Oct. 2011.

Proceeding of Domestic Conference:

1.	Yuki Iwawaki, 園井厚憲, 千葉厚子, 半田拓弥, 中津晋, Takaharu Goto, OKU Yuri, Keiko Fujimoto, Takahiro Kishimoto, Hideki Suito and Tetsuo Ichikawa : 泡沫状義歯洗浄剤OC441による義歯洗浄効果-主観的・客観的評価法による有効性の検討-, 日本義歯ケア学会第16回学術大会, Jan. 2024.
2.	Yuichi Ishida, 小西晴奈, Yuki Iwawaki, Yoritoki Tomotake and Tetsuo Ichikawa : Z世代と呼ばれる歯学部学生および研修歯科医に対する口腔インプラント治療に関するアンケート調査, 公益社団法人日本口腔インプラント学会, Sep. 2023.
3.	Yuki Iwawaki, 園井厚憲, 千葉厚子, 半田拓弥, 中津晋, Takaharu Goto, Keiko Fujimoto, Takahiro Kishimoto, Takashi Matsuda, Hideki Suito, HARUNA Konishi, Kan Nagao and Tetsuo Ichikawa : Efficacy of foam type denture cleanser OC441 on partial denture cleaning, 日本補綴歯科学会第132回学術大会, May 2023.
4.	Adityakrisna Yoshi Putra Wigianto, Takaharu Goto, Yuki Iwawaki and Tetsuo Ichikawa : Germicidal efficacy of portable UV-C light against Candida albicans biofilm on PMMA and SARS-CoV-2, 日本義歯ケア学会第15回学術大会, Jan. 2023.
5.	Norikazu Minami, Yuichi Ishida, Megumi Watanabe, Yuki Iwawaki and Tetsuo Ichikawa : インプラント治療後に顎欠損とインプラント体の破損・脱落が生じた患者に対し，ロケーターを用いた可撤式補綴装置で対応した症例, 日本口腔インプラント学会第42回中国四国支部学術大会, Nov. 2022.
6.	Norikazu Minami, Yuichi Ishida, Megumi Watanabe, Yuki Iwawaki and Tetsuo Ichikawa : --, 日本口腔インプラント学会第42回中国四国支部学術大会, Nov. 2022.
7.	Yuki Iwawaki, Norikazu Minami, Megumi Watanabe, Yoritoki Tomotake and Tetsuo Ichikawa : 表面処理されたチタン上における骨芽細胞様細胞のmicroRNA発現と細胞増殖への影響, 第52回公益社団法人日本口腔インプラント学会学術大会, Sep. 2022.
8.	Adityakrisna Yoshi Putra Wigianto, Yuki Iwawaki, Takaharu Goto, Yuichi Ishida and Tetsuo Ichikawa : カンジダのバイオフィルム形成を阻害する光反応型 MPC コーティング材の効果と耐久性, 令和4年度公益社団法人日本補綴歯科学会第131回記念学術大会, Jul. 2022.
9.	田上義弘, Keiko Fujimoto, Hideki Suito, Takahiro Kishimoto, Yuki Iwawaki, Takaharu Goto, Megumi Watanabe, Kan Nagao and Tetsuo Ichikawa : 舌超音波画像の輝度は，身体的フレイルと関係する, 一般社団法人日本老年歯科医学会第33回学術大会, Jun. 2022.
10.	田上義弘, 藤本けい子, 水頭英樹, 岸本卓大, Yuki Iwawaki, Takaharu Goto, 渡邉恵, Kan Nagao and Tetsuo Ichikawa : 舌超音波画像の輝度は身体的フレイルと関係する, 日本老年歯科医学会第33回学術大会, Jun. 2022.
11.	Adityakrisna Yoshi Putra Wigianto, Yuki Iwawaki, Takaharu Goto and Tetsuo Ichikawa : 義歯床用レジン上でのC.albicansのバイオフィルム形成に対するMPCコーティングの有効性, 日本義歯ケア学会第14回学術大会, Mar. 2022.
12.	Megumi Watanabe, Norikazu Minami, Yuki Iwawaki, Yuichi Ishida and Tetsuo Ichikawa : セマフォリン3Aはチタン上で骨芽細胞の分化を促進する, 第51回公益社団法人日本口腔インプラント学会記念学術大会, Vol.0, No.0, 00, Dec. 2021.
13.	Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto, Takashi Matsuda, Keiko Fujimoto, Kan Nagao, 吉村賢治, 江下義之, 矢納義高 and Tetsuo Ichikawa : イソデシルガラクトシド配合泡沫状製剤の高齢者における有効性の評価, 一般社団法人日本老年歯科医学会第31回学術大会, Nov. 2020.
14.	Keiko Fujimoto, Takaharu Goto, Takahiro Kishimoto, Yuki Iwawaki, 水頭英樹, Kan Nagao and Tetsuo Ichikawa : ルシフェラーゼアッセイによる口腔不潔の定量評価, 一般社団法人日本老年歯科医学会第31回学術大会, Nov. 2020.
15.	Keiko Fujimoto, Takaharu Goto, Yuki Iwawaki, Takahiro Kishimoto, 南憲一 and Tetsuo Ichikawa : ATPふき取り検査による口腔不潔の客観的評価, 日本義歯ケア学会第12回学術大会, Feb. 2020.
16.	Yuichi Ishida, Norikazu Minami, Yuki Iwawaki, Megumi Watanabe and Tetsuo Ichikawa : 木管楽器の演奏に配慮してインプラント治療を行った1症例, 四国歯学会第56回例会・徳島県歯科医学大会, Feb. 2020.
17.	Noriko Mizusawa, Yuki Iwawaki and Katsuhiko Yoshimoto : 唾液中に存在するマイクロRNAのプロファイリング, 四国歯学会第56回例会・徳島県歯科医学大会, Feb. 2020.
18.	Yuki Iwawaki, Takaharu Goto, Norikazu Minami, Yoritoki Tomotake and Tetsuo Ichikawa : 異なる表面性状を持つチタン上での骨芽細胞におけるmicroRNA発現の同定, 第49回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2019.
19.	Yoshihiro Tagami, Takaharu Goto, Keiko Fujimoto, Yuki Iwawaki, 石田雄一, Kan Nagao and Tetsuo Ichikawa : フレイル評価における音声評価の意義, 令和元年度公益社団法人日本補綴歯科学会中国四国支部学術大会, Sep. 2019.
20.	Takahiro Kishimoto, Takaharu Goto, Yuki Iwawaki, Keiko Fujimoto and Tetsuo Ichikawa : においセンサによる唾液流量推定法の検討, 平成31年度公益社団法人日本補綴歯科学会第128回学術大会, May 2019.
21.	Yuki Iwawaki, Keiko Fujimoto, Takahiro Kishimoto, Takaharu Goto and Tetsuo Ichikawa : 義歯安定剤が呼気中アルコール濃度へ与える影響の評価, 日本義歯ケア学会第11回学術大会, Feb. 2019.
22.	南憲一, Yuichi Ishida, Megumi Watanabe, Yuki Iwawaki and Tetsuo Ichikawa : 下顎無歯顎症例に対してデジタル複製義歯製作法を用いた磁性ミニインプラントオーバーデンチャーにより対応した1症例, 日本口腔インプラント学会第38回中国・四国支部学術大会, Nov. 2018.
23.	村岡佑紀, Takaharu Goto, Yuki Iwawaki, Takahiro Kishimoto and Tetsuo Ichikawa : 口腔内の清潔度と口腔機能との関連∼若年者と高齢者の比較∼, 四国歯学会第52回例会, Mar. 2018.
24.	Yuki Iwawaki, Takaharu Goto, 藤本けい子, Hideki Suito and Tetsuo Ichikawa : 高齢者における口腔機能と口腔内清浄度との関連, 日本義歯ケア学会第10回学術大会, Jan. 2018.
25.	Yuki Iwawaki, 倉橋浩輔, 檜垣宜明, Takashi Matsuda, Takaharu Goto and Tetsuo Ichikawa : 洗浄水の温度の違いによる義歯洗浄効果の検討, 日本義歯ケア学会第9回学術大会, Feb. 2017.
26.	檜垣宜明, Takaharu Goto, Yuki Iwawaki, 石田雄一, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : 咬合力維持における前頭前野の活動と感覚統合:インプラントと天然歯の比較, 第46回公益社団法人日本口腔インプラント学会・学術大会, Sep. 2016.
27.	Yuki Iwawaki, Takaharu Goto, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : マウス骨芽細胞におけるストレス誘導性microRNAの解析, 平成28年度公益社団法人日本補綴歯科学会九州支部,中国・四国支部合同学術大会, Sep. 2016.
28.	Takashi Matsuda, 倉橋宏輔, Yuki Iwawaki, Takaharu Goto, 柏原稔也, Kan Nagao, Tetsuo Ichikawa and 市場裕康 : デジタル技術を用いた全部床義歯治療の効率化:咬合圧印象用トレーによる印象採得の評価, 平成28年度公益社団法人日本補綴歯科学会第125回学術大会, Jul. 2016.
29.	Yuki Iwawaki, 檜垣宜明, Takaharu Goto, 渡邉恵, Yoritoki Tomotake and Tetsuo Ichikawa : microRNA -mirR-494-3p -, 平成27年度社団法人日本補綴歯科学会第124回学術大会, May 2015.
30.	Yuki Iwawaki, 檜垣宣明, 後藤崇晴, 渡邉恵, 友竹偉則 and 市川哲雄 : 圧縮力誘導性microRNAと機能の見当 -mirR-494-3pによる細胞増殖抑制—, 公益社団法人日本補綴歯科学会第124回学術大会, 2015.
31.	水澤典子, Yuki Iwawaki, 岩田武男 and 吉本勝彦 : ヒト顎下腺細胞株を用いた miRNA 標的遺伝子の解析, 第6回日本RNAi研究会・第1回細胞外小胞学会, 2014.
32.	小野信二, 岩田武男, 水澤典子, Yuki Iwawaki and 吉本勝彦 : ACTH 産生腺腫で低発現を認めた miR-551b の腺腫発症への関与, 第56回歯科基礎医学会学術大会・総会, 2014.
33.	Yuki Iwawaki, 水澤典子, 小野信二, 岩田武男 and 吉本勝彦 : メカニカルストレス応答性miR-494-3pによるFGFR2発現の抑制, 第56回歯科基礎医学会学術大会・総会, 2014.
34.	Yuki Iwawaki, 水澤典子, 水頭英樹, 後藤崇晴, 渡邉恵, 友竹偉則 and 市川哲雄 : メカニカルストレス応答性micro-RNA - miR-494-3pはFGFR2の発現を抑制する-, 公益社団法人日本補綴歯科学会第123回学術大会, 2014.
35.	Yuki Iwawaki, 後藤崇晴, 渡邉恵, 友竹偉則 and 市川哲雄 : メカニカルストレスに応答するmicroRNAの同定, 第43回公益社団法人日本口腔インプラント学会・学術大会, 2013.
36.	Yuki Iwawaki, 水澤典子, 岩田武男, 小野信二, 友竹偉則, 市川哲雄 and 吉本勝彦 : 機械的刺激応答性miRNAの同定, 第5回日本RNAi研究会, 2013.
37.	Yuki Iwawaki, 西中英伸, 後藤崇晴, 友竹偉則 and 市川哲雄 : インプラント上部構造における主機能部位と補綴学的問題の関連について, 第42回公益社団法人日本口腔インプラント学会・学術大会, 2012.
38.	Yuki Iwawaki, 石田雄一, 後藤崇晴, 友竹偉則 and 市川哲雄 : インプラント治療に対する認識-学生・研修医へのアンケート調査-, 第31回日本口腔インプラント学会中国四国支部総会学術大会, 2011.

Et cetera, Workshop:

1.	Yuki Iwawaki and Tetsuo Ichikawa : 萎縮した臼歯部顎堤への骨造成を伴う長い(標準長の)インプラントの代替療法としてのショートインプラントシステマティックレビューとRCTのメタアナリシス, the Quintessence, Vol.40, No.8, 213-229, Aug. 2021.
2.	Tetsuo Ichikawa, Yuki Iwawaki, Yuichi Ishida and Megumi Watanabe : 要介護高齢期を見据えた歯科インプラント治療, Dental Outlook, Vol.132, No.2, 249-277, Aug. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

骨質評価に関連するmicroRNAの同定 (Project/Area Number: 20K18575 )
Identification of microRNA related to osseointegration (Project/Area Number: 17K17174 )
Identification of microRNA related to periimplantitis (Project/Area Number: 15H06449 )
Search by Researcher Number (10754624)

Assistant Professor : Iwawaki, Yuki

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)