Tokushima University / Educator and Researcher Directory --- Ohshima, Masamitsu

Field of Study

Subject of Study

Book / Paper

Book:

1.	武尾真, 池田悦子, 仲川雅人, 小川美帆, Masamitsu Ohshima and 辻孝 : 幹細胞の自己組織化による器官再生とその展望, 株式会社エヌ・ティ・エス, Aug. 2020.

Academic Paper (Judged Full Paper):

1.	Maki Hosoki, Mayu Miyagi, Kazuo Okura, Miho Inoue, Masamitsu Ohshima, Yoshitaka Suzuki, A Ozawa, A Shibagaki, Tatsuya Taniwaki, Kouhei Kamoi, Noriyuki Bando, Yasutomo Yoshihara, M Shinkai, Toyoko Tajima, Fabillar Moreno Jaime and Yoshizo Matsuka : Proposals and evaluations for the enhancement of CAD/CAM education, Journal of Prosthodontic Research, 2024.
2.	Yoshitaka Suzuki, Kazuo Okura, Toyoko Tajima, Junhel Dalanon, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : Essence of diagnosis and management of sleep bruxism, Journal of Oral Health and Biosciences, Vol.36, No.2, 22-29, 2024. (Keyword) Sleep Bruxism / Occlusal appliance / Diagnosis / Management (Tokushima University Institutional Repository) ● Metadata: 119296 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.36.2_22 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390862555421219200 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.36.2_22 (Tokushima University Institutional Repository: 119296, DOI: 10.20738/johb.36.2_22, CiNii: 1390862555421219200)
3.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Toyoko Tajima, Mayu Miyagi, S Raman, R Raju and Yoshizo Matsuka : Identification of microRNA signatures in peripheral blood of young women as potential biomarkers for metal allergy, Biomedicines, Vol.11, No.2, 277, 2023. (Summary) MicroRNA (miRNA) is a short (19-24 nucleotide) endogenous non-protein RNA that exists in the body and controls the translation process from genes to proteins. It has become useful as a diagnostic tool and a potential treatment target in cancer research. To explore the function of miRNA in contact dermatitis, female participants with a positive metal allergy diagnosis ( = 3) were enrolled along with additional female participants with no medical history of metal allergy ( = 3). A patch test was performed on each participant. Peripheral blood was collected from all the participants before the patch test and at days 3 and 7 after starting the patch test. After total RNA was obtained from peripheral blood leukocytes and cDNA was generated, microarray analysis was performed to analyze the large-scale circulating miRNA profile. Real-time polymerase chain reaction (RT-PCR) was then used to clarify the overall target miRNA expression. Downregulation of hsa-let-7d-5p, hsa-miR-24-3p, hsa-miR-23b-3p, hsa-miR-26b-5p, and hsa-miR-150-5p was found on day 7. Certain miRNAs were confirmed using RT-PCR. These peripheral blood miRNAs could be diagnostic biomarkers for metal allergies. (Tokushima University Institutional Repository) ● Metadata: 117923 (Link to Publication Site) ● Publication site (DOI): 10.3390/biomedicines11020277 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36830814 ● Search Scopus @ Elsevier (PMID): 36830814 ● Search Scopus @ Elsevier (DOI): 10.3390/biomedicines11020277 (Tokushima University Institutional Repository: 117923, DOI: 10.3390/biomedicines11020277, PubMed: 36830814)
4.	S Raman, Arief Waskitho, R Raju, Takuma Iwasa, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Analgesic effect of tranilast in an animal model of neuropathic pain and its role in the regulation of tetrahydrobiopterin synthesis, International Journal of Molecular Sciences, Vol.23, No.11, 5878, 2022. (Tokushima University Institutional Repository) ● Metadata: 118650 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms23115878 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3390/ijms23115878 (Tokushima University Institutional Repository: 118650, DOI: 10.3390/ijms23115878)
5.	Arief Waskitho, Yumiko Yamamoto, S Raman, Fumiya Kano, Huijiao Yan, R Raju, S Afroz, Tsuyoshi Morita, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima, Akihito Yamamoto, Otto Baba and Yoshizo Matsuka : Peripherally Administered Botulinum Toxin Type A Localizes Bilaterally in Trigeminal Ganglia of Animal Model, Toxins, Vol.13, No.10, 704, 2021. (Tokushima University Institutional Repository) ● Metadata: 116383 (Link to Publication Site) ● Publication site (DOI): 10.3390/toxins13100704 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3390/toxins13100704 (Tokushima University Institutional Repository: 116383, DOI: 10.3390/toxins13100704)
6.	Masamitsu Ohshima : A case of fixed prosthodontic treatment through tooth preservation with occlusal traumatic symptoms, Annals of Japan Prosthodontic Society, Vol.13, No.4, 353-356, 2021. (Summary) <p><b>Patient:</b> A 64-year-old female patient complained of masticatory dysfunction caused by mobility of a maxillary right fixed bridge. The maxillary right canine with occlusal traumatic symptoms had been diagnosed by her previous dentist as indicated for extraction, but it was fixed with a provisional bridge to determine whether the tooth could recover. After this traumatic tooth was allowed to recover, the fabricated fixed bridge was finally attached after a follow-up observation by temporary cementation.</p><p><b>Discussion:</b> There are no clear criteria for tooth preservation of occlusal traumatic teeth depending on bone resorption or tooth mobility. Therefore, it is important to plan a step-by-step prosthodontic treatment in which the availability of abutment teeth is determined after the acute traumatic symptoms have resolved.</p><p><b>Conclusion: </b>A careful and step-by-step prosthodontic treatment for an occlusal traumatic tooth resulted in tooth preservation, restoration of masticatory function, and improvement of patient satisfaction.</p> (Keyword) 歯の保存 / 固定性補綴装置 / 咬合性外傷 / Tooth preservation / Fixed prosthesis / Occlusal trauma (Link to Publication Site) ● Publication site (DOI): 10.2186/ajps.13.353 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390571395580475776 ● Search Scopus @ Elsevier (DOI): 10.2186/ajps.13.353 (DOI: 10.2186/ajps.13.353, CiNii: 1390571395580475776)
7.	Huijiao Yan, Masamitsu Ohshima, Raju Raju, S Raman, Kazumitsu Sekine, Arief Waskitho, Miho Inoue, Masahisa Inoue, Otto Baba, Tsuyoshi Morita, Mayu Miyagi and Yoshizo Matsuka : Dentin-pulp complex tissue regeneration via three-dimensional cell sheet layering, Tissue Engineering. Part C, Methods, Vol.27, No.10, 559-570, 2021. (Summary) The dentin-pulp complex is a unique structure in teeth that contains both hard and soft tissues. Generally, deep caries and trauma cause damage to the dentin-pulp complex, and if left untreated, this damage will progress to irreversible pulpitis. The aim of this study was to fabricate a layered cell sheet composed of rat dental pulp (DP) cells and odontogenic differentiation of pulp (OD) cells and to investigate the ability to regenerate the dentin-pulp complex in a scaffold tooth. We fabricated two single cell sheets composed of DP cells (DP cell sheet) or OD cells (OD cell sheet) and a layered cell sheet made by layering both cells. The characteristics of the fabricated cell sheets were analyzed using light microscopy, scanning electron microscope (SEM), hematoxylin-eosin (HE) staining, and immunohistochemistry (IHC). Furthermore, the cell sheets were transplanted into the subrenal capsule of immunocompromised mice for 8 weeks. After this, the regenerative capacity to form dentin-like tissue was evaluated using micro-computed tomography (micro-CT), HE staining, and IHC. The findings of SEM and IHC confirmed that layered cell sheets fabricated by stacking OD cells and DP cells maintained their cytological characteristics. Micro-CT of layered cell sheet transplants revealed a mineralized capping of the access cavity in the crown area, similar to that of natural dentin. In contrast, the OD cell sheet group demonstrated the formation of irregular fragments of mineralized tissue in the pulp cavity, and the DP cell sheet did not develop any hard tissue. Moreover, bone volume/tissue volume (BV/TV) showed a significant increase in hard tissue formation in the layered cell sheet group compared with that in the single cell sheet group ( < 0.05). HE staining also showed a combination of soft and hard tissue formation in the layered cell sheet group. Furthermore, IHC confirmed that the dentin-like tissue generated from the layered cell sheet expressed characteristic markers of dentin but not bone equivalent to that of a natural tooth. In conclusion, this study demonstrates the feasibility of regenerating dentin-pulp complex using a bioengineered tissue designed to simulate the anatomical structure. Impact statement The dentin-pulp complex can be destroyed by deep caries and trauma, which may cause pulpitis and progress to irreversible pulpitis, apical periodontitis, and even tooth loss. Current treatments cannot maintain pulp health, and teeth can become brittle. We developed a three-dimensional (3D) layered cell sheet using dental pulp cells and odontogenic differentiation of pulp cells for dentin-pulp complex regeneration. Our layered cell sheet enables the regeneration of an organized 3D dentin-pulp-like structure comparable with that of natural teeth. This layered cell sheet technology may contribute to dentin-pulp complex regeneration and provide a novel method for complex tissue engineering. (Tokushima University Institutional Repository) ● Metadata: 117029 (Link to Publication Site) ● Publication site (DOI): 10.1089/ten.TEC.2021.0171 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34583551 ● Search Scopus @ Elsevier (PMID): 34583551 ● Search Scopus @ Elsevier (DOI): 10.1089/ten.TEC.2021.0171 (Tokushima University Institutional Repository: 117029, DOI: 10.1089/ten.TEC.2021.0171, PubMed: 34583551)
8.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa, Junhel Dalanon, Raju Resmi, Omar Maningo Rodis and Yoshizo Matsuka : Longitudinal comparison between flipped classroom and team-based learning in a prosthodontic class, Journal of Oral Health and Biosciences, Vol.34, No.1, 1-10, 2021. (Summary) Active learning is a concept that allows students to study and learn actively by themselves to get knowledge. There are several methods of active learning, including flipped classroom (FC) and team-based learning (TBL). In FC, students are required to study before classes. In TBL, students also study before class, take individual readiness assurance test (iRAT) and team readiness assurance test (tRAT), then discuss group assignment projects (GAPs) during class. The purpose of this study was to compare the effectiveness between FC and TBL.<br> The effectiveness of FC and TBL was assessed from the results of the term-end examinations, questionnaires and practice examinations. To check the difficulty of the term-end examinations, control dentists took the same examinations and we calculated the equating score with item response theory.<br> Statistical analysis showed that the correct answer rate in term-end examinations was significantly different in comparison with the time of the trial, and for the participants (students and dentists). The term-end examination score of FC and TBL did not show a statistical difference. The student questionnaire showed that TBL had higher scores than FC on various factors such as student positive attitude, preparation, ingenuity of teacher and achieving the class goals. The crown & bridge score from the practice examination of 6<sup>th</sup>-year students who had FC + TBL were constantly higher than the Japanese national average score. The identification index of FC and TBL did not show the statistical difference and there was no statistical difference on item response theory between FC and TBL. (Keyword) Flipped classroom / Team-based learning / Prosthodontics (Tokushima University Institutional Repository) ● Metadata: 116284 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.34.1_1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390852259674142080 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.34.1_1 (Tokushima University Institutional Repository: 116284, DOI: 10.20738/johb.34.1_1, CiNii: 1390852259674142080)
9.	Hiroo Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Risk factors for tooth loss in patients with 25 remaining teeth undergoing mid-long-term, International Journal of Environmental Research and Public Health, Vol.18, No.13, 7174, 2021. (Tokushima University Institutional Repository) ● Metadata: 116124 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijerph18137174 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85109198478 (Tokushima University Institutional Repository: 116124, DOI: 10.3390/ijerph18137174, Elsevier: Scopus)
10.	Jun Ishikawa, Makoto Takeo, Ayako Iwadate, Junko Koya, Miho Kihira, Masamitsu Ohshima, Yuki Suzuki, Kazushi Taniguchi, Ayaka Kobayashi and Takashi Tsuji : Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration, Communications Biology, Vol.4, No.1, 409, 2021. (Summary) Organogenesis and regeneration are fundamental for developmental progress and are associated with morphogenesis, size control and functional properties for whole-body homeostasis. The liver plays an essential role in maintaining homeostasis of the entire body through various functions, including metabolic functions, detoxification, and production of bile, via the three-dimensional spatial arrangement of hepatic lobules and has high regenerative capacity. The regeneration occurs as hypertrophy, which strictly controls the size and lobule structure. In this study, we established a three-dimensional sinusoidal network analysis method and determined valuable parameters after partial hepatectomy by comparison to the static phase of the liver. We found that mechanical homeostasis, which is crucial for organ morphogenesis and functions in various phenomena, plays essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks. Mechanical homeostasis plays critical roles in the initiation and termination of organogenesis, tissue repair and organ regeneration in coordination with cytokine networks. (Keyword) Animals / Capillaries / Cell Proliferation / Cells, Cultured / Cytokines / Endothelial Cells / Extracellular Signal-Regulated MAP Kinases / Hepatectomy / Hepatocytes / Homeostasis / Human Umbilical Vein Endothelial Cells / Humans / Liver / Liver Circulation / Liver Regeneration / Male / Mechanotransduction, Cellular / Mice, Inbred C57BL / Rats, Wistar / Receptors, G-Protein-Coupled (Tokushima University Institutional Repository) ● Metadata: 117439 (Link to Publication Site) ● Publication site (DOI): 10.1038/s42003-021-01936-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33828226 ● Search Scopus @ Elsevier (PMID): 33828226 ● Search Scopus @ Elsevier (DOI): 10.1038/s42003-021-01936-2 (Tokushima University Institutional Repository: 117439, DOI: 10.1038/s42003-021-01936-2, PubMed: 33828226)
11.	Yoshizo Matsuka, Masamitsu Ohshima, Kazuo Okura, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi and Miho Inoue : インドネシアの歯学部における学部教育, The Journal of Japan Association of Oral Rehabilitation, Vol.33, No.1, 53-57, 2020. (Keyword) Undergraduate student education / dental school / Indonesia (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572359516377600 (CiNii: 1520572359516377600)
12.	Susumu Abe, Miyagi Akane, Kaoru Yoshinaga, Yoshizo Matsuka, Fumihiro Matsumoto, Uyama Emi, Yoshitaka Suzuki, Masamitsu Ohshima, Kazuo Okura and Eiji Tanaka : Immediate Effect of Masticatory Muscle Activity with Transcutaneous Electrical Nerve Stimulation in Muscle Pain of Temporomandibular Disorders Patients, Journal of Clinical Medicine, Vol.9, No.10, 3330, 2020. (Summary) Transcutaneous electrical nerve stimulation (TENS) is a non-invasive treatment modality for acute and chronic pain. However, little information for muscle activity is available on the immediate effects of TENS in masticatory muscle pain related to temporomandibular disorders (TMDs). The present study aimed to evaluate the immediate effects of TENS treatment on TMD-related muscle pain. Thirty-six patients with TMD-related muscle pain and 39 healthy subjects served as TMD and control groups, respectively. For objective evaluations, maximum mouth opening, and maximum bite force were measured before and after TENS. The pain intensity was assessed according to a 100-mm visual analog scale (VAS). TENS was applied to painful muscles for 20 min with frequencies of 100-200 Hz. The treatment outcome was evaluated using Global Rating of Change (GRC) scales. In the TMD group, VAS values significantly decreased after TENS. Although there was significant increase in the maximum mouth opening after TENS for only TMD group, the maximum bite force of both groups was significantly greater after TENS. According to GRC scales, one patient with TMD-related muscle pain expressed negative feelings after TENS. Conclusively, TENS treatment might quickly relieve pain in masticatory muscles and improve masticatory functions in patients with TMD-related muscle pain. (Link to Publication Site) ● Publication site (DOI): 10.3390/jcm9103330 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33081336 ● Search Scopus @ Elsevier (PMID): 33081336 ● Search Scopus @ Elsevier (DOI): 10.3390/jcm9103330 (DOI: 10.3390/jcm9103330, PubMed: 33081336)
13.	H Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Risk factors for tooth loss in patients undergoing mid long-term maintenance: A retrospective study, International Journal of Environmental Research and Public Health, Vol.17, No.17, E6258, 2020. (Summary) In this retrospective study, we identified risk factors for tooth loss in patients undergoing mid-long-term maintenance therapy. We surveyed 674 maintenance patients for ≥5 years after active treatment who visited a dental clinic between January 2015 and December 2016. Of these, 265 were men (mean age 54.6 ± 8.0 years old) and 409 were women (mean age 54.0 ± 7.9 years old). Study variables included patient compliance, sex, number of teeth lost, cause of tooth loss (dental caries, periodontal disease, root fracture, others, vital or non-vital teeth), age at start of maintenance, number of remaining teeth at start of maintenance, smoking, use of salivary secretion inhibitors, presence of diabetes mellitus, condition of periodontal bone loss, and use of a removable denture. Most lost teeth were non-vital teeth (91.7% of all cases) and the most common cause of tooth loss was tooth fracture (62.1% of all cases). A statistically significant risk factors for tooth loss was number of remaining teeth at the start of maintenance ( = 0.003). (Tokushima University Institutional Repository) ● Metadata: 115160 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijerph17176258 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32867387 ● Search Scopus @ Elsevier (PMID): 32867387 ● Search Scopus @ Elsevier (DOI): 10.3390/ijerph17176258 (Tokushima University Institutional Repository: 115160, DOI: 10.3390/ijerph17176258, PubMed: 32867387)
14.	S Afroz, Rieko Arakaki, Takuma Iwasa, Arief Waskitho, Masamitsu Ohshima and Yoshizo Matsuka : Role of CGRP in neuroimmune interaction via NFkB signalling genes in glial cells of trigeminal ganglia, International Journal of Molecular Sciences, Vol.21, No.17, 6005, 2020. (Summary) Activation of the trigeminal system causes the release of various neuropeptides, cytokines, and other immune mediators. Calcitonin gene-related peptide (CGRP), which is a potent algogenic mediator, is expressed in the peripheral sensory neurons of trigeminal ganglion (TG). It affects the inflammatory responses and pain sensitivity by modulating the activity of glial cells. The primary aim of this study was to use array analysis to investigate the effect of CGRP on the glial cells of TG in regulating nuclear factor kappa B (NF-κB) signaling genes and to further check if CGRP in the TG can affect neuron-glia activation in the spinal trigeminal nucleus caudalis. The glial cells of TG were stimulated with CGRP or Minocycline (Min) + CGRP. The effect on various genes involved in NF-κB signaling pathway was analyzed compared to no treatment control condition using a PCR array analysis. CGRP, Min + CGRP or saline was directly injected inside the TG and the effect on gene expression of , and and protein expression of cleaved Caspase3 (cleav Casp3) in the TG, and c-Fos and glial fibrillary acidic protein (GFAP) in the spinal section containing trigeminal nucleus caudalis was analyzed. Results showed that CGRP stimulation resulted in the modulation of several genes involved in the interleukin 1 signaling pathway and some genes of the tumor necrosis factor pathway. Minocycline pre-treatment resulted in the modulation of several genes in the glial cells, including anti-inflammatory genes, and neuronal activation markers. A mild increase in cleav Casp3 expression in TG and c-Fos and GFAP in the spinal trigeminal nucleus of CGRP injected animals was observed. These data provide evidence that glial cells can participate in neuroimmune interaction due to CGRP in the TG via NF-κB signaling pathway. (Tokushima University Institutional Repository) ● Metadata: 115116 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms21176005 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32825453 ● Summary page in Scopus @ Elsevier: 2-s2.0-85089699772 (Tokushima University Institutional Repository: 115116, DOI: 10.3390/ijms21176005, PubMed: 32825453, Elsevier: Scopus)
15.	Resmi Raju, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Arief Waskitho, Otto Baba, Masahisa Inoue and Yoshizo Matsuka : Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet, Scientific Reports, Vol.10, No.1, 1656, 2020. (Summary) Periodontal tissue is a distinctive tissue structure composed three-dimensionally of cementum, periodontal ligament (PDL) and alveolar bone. Severe periodontal diseases cause fundamental problems for oral function and general health, and conventional dental treatments are insufficient for healing to healthy periodontal tissue. Cell sheet technology has been used in many tissue regenerations, including periodontal tissue, to transplant appropriate stem/progenitor cells for tissue regeneration of a target site as a uniform tissue. However, it is still difficult to construct a three-dimensional structure of complex tissue composed of multiple types of cells, and the transplantation of a single cell sheet cannot sufficiently regenerate a large-scale tissue injury. Here, we fabricated a three-dimensional complex cell sheet composed of a bone-ligament structure by layering PDL cells and osteoblast-like cells on a temperature responsive culture dish. Following ectopic and orthotopic transplantation, only the complex cell sheet group was demonstrated to anatomically regenerate the bone-ligament structure along with the functional connection of PDL-like fibers to the tooth root and alveolar bone. This study represents successful three-dimensional tissue regeneration of a large-scale tissue injury using a bioengineered tissue designed to simulate the anatomical structure. (Tokushima University Institutional Repository) ● Metadata: 114213 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-020-58222-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32015383 ● Search Scopus @ Elsevier (PMID): 32015383 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-58222-0 (Tokushima University Institutional Repository: 114213, DOI: 10.1038/s41598-020-58222-0, PubMed: 32015383)
16.	Yoshizo Matsuka, S Afroz, Junhel Dalanon, Takuma Iwasa, Arief Waskitho and Masamitsu Ohshima : The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion, Neuroscience and Biobehavioral Reviews, Vol.108, 393-399, 2020. (Summary) Neuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotransmitters or the other modulators such as inflammatory substances produced by the ganglion cells, because of an injury, are responsible for the cross-excitation between neurons and neuron-glial interaction, thus affecting chemical transmission. This chemical transmission is considered mainly responsible for the chronicity and the persistent nature of neuropathic pain. This review examines the pain signalling due to neurotransmitter or cytokine release within the sensory ganglia. The specific areas focused on include: 1) the role of neurotransmitters released from the somata of sensory neurons in pain, 2) neuron-glia interaction and 3) role of cytokines in neuromodulation and pain. (Tokushima University Institutional Repository) ● Metadata: 114079 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neubiorev.2019.11.019 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31785264 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076002926 (Tokushima University Institutional Repository: 114079, DOI: 10.1016/j.neubiorev.2019.11.019, PubMed: 31785264, Elsevier: Scopus)
17.	Mahmoud Farahat, Gulsan A.S. Kazi, Hiroaki Taketa, Emilio S. Hara, Masamitsu Ohshima, Takuo Kuboki and Takuya Matsumoto : Fibronectin-induced ductal formation in salivary gland self-organization model, Developmental Dynamics, Vol.248, No.9, 813-825, 2019. (Summary) Recent advances in tissue regeneration approaches including 3D organoids, were based on various 3D organogenesis models. However, 3D models are generally technique-sensitive and time-consuming. Thus, we utilized an existing model of submandibular salivary gland (SMG) to modify a simple and highly reproducible in vitro 3D culture model of primary SMG cells self-organization into a well-developed cell spheroid inside Matrigel substrate. We used this model to observe the collective multicellular behavior during spheroid formation. Further, we applied various quantitative approaches including real-time live imaging and immune histochemical image analysis to dissect the cellular dynamics during tissue patterning. On a time-scale of hours, we observed marked size and shape transformations in the developed 3D spheroid which resulted in a spatially-controlled growth differential from the canter to the periphery of the formed aggregates. Moreover, we investigated the effect of fibronectin (FN) on SMG cells self-organization using our simplified culture model. Interestingly, we discovered a novel role of FN in inducing duct-like elongation during initial stages of SMG bud formation. This in vitro model provides an excellent tool for analyzing the intercellular dynamics during early SMG tissue development as well as revealing a novel role of FN in SMG ductal expansion. (Keyword) Animals / Cell Culture Techniques / Cells, Cultured / collagen / Drug Combinations / Fibronectins / Laminin / Mice / Organogenesis / Proteoglycans / Salivary Ducts / salivary glands / Spheroids, Cellular / Submandibular Gland (Link to Publication Site) ● Publication site (DOI): 10.1002/dvdy.78 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31237723 ● Summary page in Scopus @ Elsevier: 2-s2.0-85069903335 (DOI: 10.1002/dvdy.78, PubMed: 31237723, Elsevier: Scopus)
18.	Takuma Iwasa, S Afroz, Miho Inoue, Rieko Arakaki, Masamitsu Ohshima, R Raju, Arief Waskitho, Inoue Masahisa, Otto Baba and Yoshizo Matsuka : IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain, Neuroscience Letters, Vol.703, 132-138, 2019. (Tokushima University Institutional Repository) ● Metadata: 113686 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2019.03.031 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2019.03.031 (Tokushima University Institutional Repository: 113686, DOI: 10.1016/j.neulet.2019.03.031)
19.	Mio Naritani, Miho Inoue, Resmi Raju, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka : Analysis of Bone Marrow-derived Mesenchymal Stem Cell Kinetics after Short-term Stimulation with Tumor Necrosis Factor-α (TNF-α), Journal of Hard Tissue Biology, Vol.28, No.2, 99-108, 2019. (Tokushima University Institutional Repository) ● Metadata: 113372 (Link to Publication Site) ● Publication site (DOI): 10.2485/jhtb.28.99 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85065527448 (Tokushima University Institutional Repository: 113372, DOI: 10.2485/jhtb.28.99, Elsevier: Scopus)
20.	Rika Hayama, Yukari Kanemitsu, Chisato Goda, Susumu Abe, Kazuo Okura, Shaista Afroz, Nami Goto, Resmi Raju, Junhel Dalanon, Masamitsu Ohshima, Omar Maningo Rodis, Yoshihiro Okayama, Fumiaki Kawano and Yoshizo Matsuka : Quality of life and job satisfaction among female dentists in Japan, Journal of Oral Health and Biosciences, Vol.31, No.2, 79-86, 2019. (Tokushima University Institutional Repository) ● Metadata: 113013 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.31.2_79 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390564238075555456 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.2_79 (Tokushima University Institutional Repository: 113013, DOI: 10.20738/johb.31.2_79, CiNii: 1390564238075555456)
21.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka : CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception, International Journal of Molecular Sciences, Vol.20, No.3, 711, 2019. (Summary) Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG) secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) modulates pain transmission through neuron-glia signaling, contributing to various orofacial pain conditions. The present study aimed to investigate the role of satellite glial cells (SGC) in TG in causing cytokine-related orofacial nociception in response to IG administration of CGRP. For that purpose, CGRP alone (10 μL of 10 M), Minocycline (5 μL containing 10 μg) followed by CGRP with one hour gap (Min + CGRP) were administered directly inside the TG in independent experiments. Rats were evaluated for thermal hyperalgesia at 6 and 24 h post-injection using an operant orofacial pain assessment device (OPAD) at three temperatures (37, 45 and 10 °C). Quantitative real-time PCR was performed to evaluate the mRNA expression of IL-1β, IL-6, TNF-α, IL-1 receptor antagonist (IL-1RA), sodium channel 1.7 (NaV 1.7, for assessment of neuronal activation) and glial fibrillary acidic protein (GFAP, a marker of glial activation). The cytokines released in culture media from purified glial cells were evaluated using antibody cytokine array. IG CGRP caused heat hyperalgesia between 6-24 h (paired- test, < 0.05). Between 1 to 6 h the mRNA and protein expressions of GFAP was increased in parallel with an increase in the mRNA expression of pro-inflammatory cytokines IL-1β and anti-inflammatory cytokine IL-1RA and NaV1.7 (one-way ANOVA followed by Dunnett's post hoc test, < 0.05). To investigate whether glial inhibition is useful to prevent nociception symptoms, Minocycline (glial inhibitor) was administered IG 1 h before CGRP injection. Minocycline reversed CGRP-induced thermal nociception, glial activity, and down-regulated IL-1β and IL-6 cytokines significantly at 6 h (-test, < 0.05). Purified glial cells in culture showed an increase in release of 20 cytokines after stimulation with CGRP. Our findings demonstrate that SGCs in the sensory ganglia contribute to the occurrence of pain via cytokine expression and that glial inhibition can effectively control the development of nociception. (Tokushima University Institutional Repository) ● Metadata: 113687 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms20030711 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30736422 ● Summary page in Scopus @ Elsevier: 2-s2.0-85061270594 (Tokushima University Institutional Repository: 113687, DOI: 10.3390/ijms20030711, PubMed: 30736422, Elsevier: Scopus)
22.	Oyanagi Toshihito, Takeshita Nobuo, Hara Mamiko, Ikeda Etsuko, Chida Toko, Seki Daisuke, Yoshida Michiko, Seiryu Masahiro, Takano Ikuko, Kimura Seiji, Masamitsu Ohshima, Tsuji Takashi and Takano-Yamamoto Teruko : Insulin-like growth factor 1 modulates bioengineered tooth morphogenesis, Scientific Reports, Vol.9, No.1, 368, 2019. (Summary) Regenerative therapy to replace missing teeth is a critical area of research. Functional bioengineered teeth have been produced by the organ germ method using mouse tooth germ cells. However, these bioengineered teeth are significantly smaller in size and exhibit an abnormal crown shape when compared with natural teeth. The proper sizes and shapes of teeth contribute to their normal function. Therefore, a method is needed to control the morphology of bioengineered teeth. Here, we investigated whether insulin-like growth factor 1 (IGF1) can regulate the sizes and shapes of bioengineered teeth, and assessed underlying mechanisms of such regulation. IGF1 treatment significantly increased the size of bioengineered tooth germs, while preserving normal tooth histology. IGF1-treated bioengineered teeth, which were developed from bioengineered tooth germs in subrenal capsules and jawbones, showed increased sizes and cusp numbers. IGF1 increased the number of fibroblast growth factor (Fgf4)-expressing enamel knots in bioengineered tooth germs and enhanced the proliferation and differentiation of dental epithelial and mesenchymal cells. This study is the first to reveal that IGF1 increases the sizes and cusp numbers of bioengineered teeth via the induction of enamel knot formation, as well as the proliferation and differentiation of dental epithelial and mesenchymal cells. (Tokushima University Institutional Repository) ● Metadata: 114950 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-018-36863-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30675004 ● Summary page in Scopus @ Elsevier: 2-s2.0-85060395304 (Tokushima University Institutional Repository: 114950, DOI: 10.1038/s41598-018-36863-6, PubMed: 30675004, Elsevier: Scopus)
23.	Miho Inoue, Mio Naritani, R Raju, Mayu Miyagi, Masamitsu Ohshima, Inoue Masahisa and Yoshizo Matsuka : Effect of short-term Tumour Necrosis Factor-alpha (TNF-α) -stimulation on the growth and differentiation of MC3T3-E1 osteoblast-like cells, Journal of Hard Tissue Biology, Vol.27, No.3, 213-218, 2018. (Tokushima University Institutional Repository) ● Metadata: 113362 (Link to Publication Site) ● Publication site (DOI): 10.2485/jhtb.27.213 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85049948297 (Tokushima University Institutional Repository: 113362, DOI: 10.2485/jhtb.27.213, Elsevier: Scopus)
24.	Gantumur Chimeddulam, Keisuke Nishigawa, Yoshihito Naitou, Junhel Dalanon, S Afroz, Rika Hayama, Masamitsu Ohshima, Yoritoki Tomotake, Tetsuo Ichikawa and Yoshizo Matsuka : Radiographic investigation of the marginal bone loss on dental implants, a retrospective cohort study, Journal of Oral Health and Biosciences, Vol.31, No.1, 13-24, 2018. (Summary) <b>Background:</b> During functional loading, the design of the dental implant may have an effect on the response of marginal bone.<br><b>Objectives:</b> The purpose of this study was to report the prevalence of peri-implantitis, and to compare radiographic parameters around Brånemark and Replace Select dental implants and evaluate whether disparities in the morphologic features of these two indistinct implant systems, particularly their abutment-implant attachment, had an influence on the health of surrounding tissues and marginal bone loss (MBL).<br><b>Materials and Methods:</b> Collection of data was done at the Department of Fixed Prosthodontics, the Department of Maxillo-Facial Prosthodontics, and Oral Implant Center of Tokushima University Hospital, in Tokushima, Japan; between March 2003 and followed until January 2017. Patients who have been treated with the Replace Select internal type implant and the Brånemark variety were selected as cohort. Marginal bone level measurements were evaluated via periapical and panoramic radiographs taken at regular follow-up visit. These dimensions were calculated, starting from the orientation mark at the implant abutment interface to the bottommost perceived contact area of marginal bone with the aforementioned implant system. The change in the level of bone was estimated by calculating the variation involving an initial reference value and the follow-up values.<br><b>Results:</b> An average loss of bone at 0.65 ± 1.51 mm (range 0.36 to 7.89 mm) in the Replace Select group was observed, while in the Brånemark group 0.7 ± 1.32 mm (range 0.62 to 8.64 mm) was observed. Spearman rank correlation exhibited a statistically significant positive correlation between progress of bone loss around implant body and interval from implantation in the Brånemark group, whereas in the Replace Select group it was not significant. The Brånemark group exhibited significant (P = 0.0269) negative correlation of MBL and its diameters, whereas the Replace Select group did not exhibit such correlation.<br><b>Conclusion:</b> Within the limits of this study, it can be concluded that deviations in the morphologic attributes of these two diverse implant systems had an influence on the health of surrounding tissues and MBL. The Brånemark implants showed a significant increase in MBL (> 1.8mm) as the time of placement elapses. This marked MBL was greater in females than males, in posterior than in anterior, and in the narrow platform implants than the regular platform implants or the wide platform implants. On the other hand, results suggested that this bone loss was greater in the mandible than the maxilla, in single-unit implant crowns than multiple implant restorations in the Replace Select group. (Keyword) dental implant / marginal bone loss / retrospective cohort study / implant design (Tokushima University Institutional Repository) ● Metadata: 111932 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.31.1_13 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282763020251776 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_13 (Tokushima University Institutional Repository: 111932, DOI: 10.20738/johb.31.1_13, CiNii: 1390282763020251776)
25.	Yoshizo Matsuka, 玉置勝司, Rika Hayama, Susumu Abe, 宮城麻友, Eriko Horikawa, Mio Naritani, 野田千織, Masamitsu Ohshima and Fumiaki Kawano : 咬合違和感の診断と対処法, Annals of Japan Prosthodontic Society, Vol.10, No.2, 129-133, 2018. (Link to Publication Site) ● Publication site (DOI): 10.2186/ajps.10.129 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205299655552 ● Search Scopus @ Elsevier (DOI): 10.2186/ajps.10.129 (DOI: 10.2186/ajps.10.129, CiNii: 1390001205299655552)
26.	Masamitsu Ohshima, Ogawa Miho and Tsuji Takashi : Regeneration of complex oral organs using 3D cell organization technology, Current Opinion in Cell Biology, Vol.49, 84-90, 2017. (Summary) The development of organoid techniques for regenerative therapy has progressed remarkably with the use of tissue-derived stem cells and pluripotent stem cells based on stem cell biology and tissue engineering technology. To realize whole-organ replacement therapy as next-generation regenerative medicine, it is expected that fully functional bioengineered organs can be reconstructed using an in vitro three-dimensional (3D) bioengineered organ germ and organoids by stem cell manipulation and self-organization. In this mini-review, we focused on substantial advances of 3D bioengineering technologies for the regeneration of complex oral organs with the reconstruction of 3D bioengineered organ germ using organ-inductive potential embryo-derived epithelial and mesenchymal cells. These bioengineering technologies have the potential for realization of future organ replacement therapy. (Keyword) Biomedical Engineering / Humans / Organoids / Regeneration / Regenerative Medicine / Tissue Engineering (Tokushima University Institutional Repository) ● Metadata: 115079 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ceb.2017.12.011 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29289879 ● Summary page in Scopus @ Elsevier: 2-s2.0-85039699426 (Tokushima University Institutional Repository: 115079, DOI: 10.1016/j.ceb.2017.12.011, PubMed: 29289879, Elsevier: Scopus)
27.	Mitsuaki Ono, Masamitsu Ohshima, Miho Ogawa, Wataru Sonoyama, Emilio Satoshi Hara, Yasutaka Oida, Shigehiko Shinkawa, Ryu Nakajima, Atsushi Mine, Satoru Hayano, Satoshi Fukumoto, Shohei Kasugai, Akira Yamaguchi, Takashi Tsuji and Takuo Kuboki : Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model., Scientific Reports, Vol.7, 44522, 2017. (Summary) Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after autologous transplantation and achieved physiological function equivalent to that of a natural tooth. This study represents a substantial advancement in whole-organ replacement therapy through the transplantation of bioengineered organ germ as a practical model for future clinical regenerative medicine. (Tokushima University Institutional Repository) ● Metadata: 112433 (Link to Publication Site) ● Publication site (DOI): 10.1038/srep44522 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28300208 ● Summary page in Scopus @ Elsevier: 2-s2.0-85015453645 (Tokushima University Institutional Repository: 112433, DOI: 10.1038/srep44522, PubMed: 28300208, Elsevier: Scopus)
28.	Kunimichi Niibe, Fumio Suehiro, Masamitsu Ohshima, Masahiro Nishimura, Takuo Kuboki and Hiroshi Egusa : Challenges for stem cell-based "regenerative prosthodontics"., Journal of Prosthodontic Research, Vol.61, No.1, 3-5, 2016. (Keyword) Alveolar Ridge Augmentation / Bone Marrow Cells / Bone Regeneration / Humans / Prosthodontics / Regenerative Medicine / Stem Cells (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jpor.2016.09.001 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27720168 ● Summary page in Scopus @ Elsevier: 2-s2.0-85000978514 (DOI: 10.1016/j.jpor.2016.09.001, PubMed: 27720168, Elsevier: Scopus)

Review, Commentary:

1.	Tetsuo Ichikawa, 小野高裕, 會田英紀, 飯沼利光, 尾澤昌悟, 中島純子, 松田謙一, 水口一, 長谷川陽子, 大川周治, 藤澤政紀, 西村正宏, 鬼原英道, 丸尾勝一郎, 峯篤史, 佐藤雅介, 村上小夏, 馬場一美, Yoshizo Matsuka, 玉置勝司, Kazuo Okura, 西山暁 and Masamitsu Ohshima : リラインとリベースの臨床指針2023, The Journal of the Japan Prosthodontic Society, 1-43, Mar. 2023.
2.	Tetsuo Ichikawa, 小野高裕, 會田英紀, 飯沼利光, 尾澤昌悟, 中島純子, 松田謙一, 水口一, 長谷川陽子, 大川周治, 藤澤政紀, 西村正宏, 鬼原英道, 丸尾勝一郎, 峯篤史, 佐藤雅介, 村上小夏, 石井智浩, 佐藤佑介, 西尾健介, 西山雄一郎, 吉岡文, 吉田和弘, 渡辺崇文, 馬場一美, Yoshizo Matsuka, 玉置勝司, Kazuo Okura, 西山暁, Masamitsu Ohshima, 河相安彦, 水口俊介, 武部純, 鱒見進一, 村田比呂司, 大久保力廣 and 横山文典 : 軟質リライン材によるリラインのガイドイン2023, The Journal of the Japan Prosthodontic Society, 1-69, Mar. 2023.
3.	鮎川保則, 會田英紀, 秋山謙太郎, Masamitsu Ohshima, 佐藤洋平, 廣安一彦, 古屋純一, 山田陽一, 澤瀬隆 and 窪木拓男 : Development of Evidence-based Difficulty Assessment Tool in Implant Dentistry, Journal of Japanese Society of Oral Implantology, Vol.35, No.2, 83-91, Jun. 2022. (Keyword) 口腔インプラント (Link to Publication Site) ● Publication site (DOI): 10.11237/jsoi.35.83 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390574334767271680 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.35.83 (DOI: 10.11237/jsoi.35.83, CiNii: 1390574334767271680)
4.	Masamitsu Ohshima and 辻孝 : 歯根膜を有する次世代型バイオハイブリッドインプラントの開発, Orthopeadics and Traumatology, Vol.63, No.10, 1409-1416, Sep. 2020. (Keyword) Dental implant / Periodontal tissue / Bio-hybrid artificial organ (Link to Publication Site) ● Publication site (DOI): 10.18888/se.0000001462 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390567172575104000 ● Search Scopus @ Elsevier (DOI): 10.18888/se.0000001462 (DOI: 10.18888/se.0000001462, CiNii: 1390567172575104000)
5.	Masamitsu Ohshima and 辻孝 : 次世代器官再生医療, 歯科再生医学, 294-307, Apr. 2019.
6.	Masamitsu Ohshima : 歯科補綴学の立場から, 新春座談会山中教授と若手研究者が語る!幹細胞,iPS細胞の歯科学への応用と未来, Vol.38, No.1, 30-41, Jan. 2019.
7.	Masamitsu Ohshima and 辻孝 : 歯・歯周組織を包括的に再生可能な歯科再生医療の技術開発, 大阪口腔インプラント研究会会報, No.32, 14-19, Mar. 2018.
8.	辻孝 and Masamitsu Ohshima : 歯根膜付きインプラントの臨床応用はいつ実現するのか⁉, クインテッセンス・デンタルインプラントロジー, Vol.25, No.1, 64-73, Jan. 2018.
9.	Masamitsu Ohshima and Takashi Tsuji : Functional ectodermal organ regeneration based on epithelial and mesenchymal interactions, Regenerative Engineering and Developmental Biology, Vol.1, No.1, 433-462, Sep. 2017. (Link to Publication Site) ● Publication site (DOI): 10.1201/9781315120188 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85053591737 (DOI: 10.1201/9781315120188, Elsevier: Scopus)
10.	Masamitsu Ohshima, 大野充昭, 辻孝 and 窪木拓男 : 歯科再生医療の実現に向けた大型動物モデルにおける機能的な歯の再生, 月刊BIO INDUSTRY, Vol.34, No.9, 1-11, Sep. 2017.
11.	窪木拓男, Masamitsu Ohshima and 大野充昭 : 高度な硬軟両組織マネージメントと補綴歯科治療のコラボレーション, 日本歯科補綴学会雑誌, Vol.9, No.2, 132-136, May 2017.
12.	Masamitsu Ohshima and Tsuji Takashi : Functional Tooth Regeneration, Organ Regeneration Based on Developmental Biology, Vol.1, No.1, 73-95, Apr. 2017. (Link to Publication Site) ● Publication site (DOI): 10.1007/978-981-10-3768-9_5 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85028871300 (DOI: 10.1007/978-981-10-3768-9_5, Elsevier: Scopus)

Proceeding of International Conference:

1.	Lutfi Perdana, R Raju, Jaime Fabillar, Dara Arini, S Raman, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka : Investigating the antinociceptive mechanism of ril-10: a novel therapeutic target for orofacial pain, Asian Academy of Orofacial Pain and Temporomandibular Disorders, Taipei, Nov. 2024.
2.	Perdana P Lutfi, Masamitsu Ohshima, Daisuke Ikutame and Yoshizo Matsuka : The potent effect of IL-10 induced β-endorphin on alleviating trigeminal neuropathic pain, Asian Academy of Prosthodontics, Chiba, Jul. 2024.
3.	R Swarna, Arief Waskitho, Masamitsu Ohshima and Yoshizo Matsuka : Tetrahydrobiopterin pathway: A therapeutic target for neuropathic pain model, International Association for Dental Research Japanese Devision, Online, Oct. 2021.
4.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka : CGRP induced glial-cytokine expression, NFkB signaling and orofacial nociception, International Association for Dental Research, Washington, D.C., Mar. 2020.
5.	R Raju, Masamitsu Ohshima, Tsuyoshi Morita, Huijiao Yan, Miho Inoue, Otto Baba, Masahisa Inoue and Yoshizo Matsuka : A double-layered complex cell sheet can regenerate the periodontal tissue in a mice model, Dentisphere, Surabayai, Nov. 2019.
6.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Otto Baba, Y Okayama and Yoshizo Matsuka : Orofacial pain due to glial expressed cytokines in trigeminal ganglion, Dentisphere, Surabayai, Nov. 2019.
7.	Arief Waskitho, Yumiko Yamamoto, Tsuyoshi Morita, Huijiao Yan, R Raju, Masamitsu Ohshima, Junhel Dalanon, Otto Baba and Yoshizo Matsuka : Bilateral effects of unilateral administration of botulinum toxin A in chemotherapy induced neuropathy, Dentisphere, Surabayai, Nov. 2019.
8.	S Afroz, Rieko Arakaki, Takuma Iwasa, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Otto Baba, Yoshihiro Okayama and Yoshizo Matsuka : Orofacial nociception due to glial expressed cytokines in trigeminal ganglia, International Association for Dental Research, Vancouver, Jun. 2019.
9.	Yoshizo Matsuka, Afroz Shaista, Dalanon Junhel, Iwasa Takuma and Masamitsu Ohshima : Neurotransmitters in orofacial pain transmission mechanisms, Philippine Dental Association, Cebu, May 2018.
10.	Yoshizo Matsuka, Afroz Shaista, Dalanon Junhel, Iwasa Takuma and Masamitsu Ohshima : Neurotransmitters in orofacial pain transmission mechanisms, Asia Pacific Dental Congress, Manila, May 2018.
11.	Masamitsu Ohshima : Functional tooth regenerative technology asa a future bioengineered organ replacement therapy., Taiwan Orthodontic Society (TOS) Annual Meeting, Taipei, Sep. 2017.

Proceeding of Domestic Conference:

1.	谷脇竜弥, Maki Hosoki, Masamitsu Ohshima, Kazuo Okura, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Mayu Miyagi, 伸幸板東, OZAWA Aya, 吉原靖智, 新開瑞希, 柴垣あかり, 青木映璃, Kouhei Kamoi and Yoshizo Matsuka : 徳島大学における補綴学実習の評価と改善, 大学教育カンファレンスin徳島, Dec. 2024.
2.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Masamitsu Ohshima, Mariko Niki, Yoshiaki Kubo and Yoshizo Matsuka : ピアスの金属成分分析と金属アレルギー発症リスクについて, 日本アレルギー学会, Oct. 2024.
3.	(名) Lutfi, Raman Swarna, (名) Jaime, (名) Dara, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka : β-endorphin induced by rIL-10 serves as a potential target for alleviating trigeminal neuropathic pain, The 49th Okayama Brain Research Seminar, Sep. 2024.
4.	(名) Jaime, Raman Swarna, (名) Lutfi, Masamitsu Ohshima, Kazuo Okura and Yoshizo Matsuka : Bilateral transport of neuronal tracer after unilateral administration, The 49th Okayama Brain Research Seminar, Sep. 2024.
5.	Kazuyuki Koike, Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, 吉原靖智, 谷脇竜弥, Masamitsu Ohshima and Yoshizo Matsuka : 掌蹠膿疱症性骨関節炎における歯科金属除去の重要性:症例報告と考察, 日本補綴学会中国四国支部学術大会, Aug. 2024.
6.	谷脇竜弥, Maki Hosoki, Mayu Miyagi, 伸幸板東, Masamitsu Ohshima, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Aya OZAWA, 青木映璃, 吉原靖智, Kazuo Okura, 新開瑞希, 柴垣あかり and Yoshizo Matsuka : クラウンブリッジ補綴学模型実習の改善:アンケート調査に基づく分析, The Journal of the Japan Prosthodontic Society, Jul. 2024.
7.	Masamitsu Ohshima : 歯周組織の解剖学的構造と生理機能を有する次世代型バイオインプラントの開発, 日本再生医療学会, Mar. 2024.
8.	Putra Lutfi Perdana, Swarna Lakshmi Raman, Fabillar Jr. Jaime Moreno, Arini Sari Dara, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka : Pain-relief mechanism of IL-10 in the trigeminal ganglia: insights into trigeminal neuropathic pain management, Brain Science cluster minirtreat, Feb. 2024.
9.	Eri Aoki, Yoshitaka Suzuki, Mizuki Shinkai, Aya Ozawa, Akari Shibagaki, Tatsuya Taniwaki, Yasutomo Yoshihara, Kazuo Okura, Miho Inoue, 池田隆志, Masamitsu Ohshima and Yoshizo Matsuka : 睡眠体位療法による睡眠時ブラキシズムへの効果の検討, 日本補綴学会中国四国支部学術大会, Sep. 2023.
10.	Masamitsu Ohshima, Miho Inoue, Mayu Miyagi and Yoshizo Matsuka : 複合組織の立体構築による歯の組織再生技術の開発, 公益社団法人日本補綴歯科学会令和5年度中国四国支部学術大会, Sep. 2023.
11.	Kaho Yumoto, Yoshitaka Suzuki, Kouhei Kamoi, Kazuo Okura, Aya Ozawa, SHINKAI Mizuki, TANIWAKI Tatsuya, Toshinori Okawa, Daisuke Takegawa, Masamitsu Ohshima and Yoshizo Matsuka : デジタルワークフローを用いたミュージックスプリント内面のデザインに関する予備検討, The Journal of the Japan Prosthodontic Society, May 2023.
12.	Aya Ozawa, Yoshitaka Suzuki, Toyoko Tajima, Toshinori Okawa, Kouhei Kamoi, Kazuo Okura, 谷脇竜弥, Miho Inoue, 吉原靖智, Masamitsu Ohshima, Susumu Abe and Yoshizo Matsuka : 睡眠時ブラキシズム患者の適応したアプライアンスの変形を長期間観察した症例, The Journal of the Japan Prosthodontic Society, May 2023.
13.	Yasutomo Yoshihara, TANIWAKI Tatsuya, Yoshitaka Suzuki, Kazuo Okura, Shuji Shigemoto, Toyoko Tajima, Susumu Abe, Masamitsu Ohshima, 小川匠, Eiichi Bando, Fumiaki Kawano and Yoshizo Matsuka : 睡眠時ブラキシズムと意識下における側方滑走運動の水平面顎運動軌跡の比較, The Journal of the Japan Prosthodontic Society, May 2023.
14.	Miho Inoue, Masamitsu Ohshima, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : 口腔顔面痛はアロマテラピーで軽減する∼口腔顔面痛モデル動物での評価∼, The Journal of the Japan Prosthodontic Society, May 2023.
15.	Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸板東, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, SHINKAI Mizuki and Yoshizo Matsuka : デジタル化に対応したクラウンブリッジ補綴学実習の検討, The Journal of the Japan Prosthodontic Society, May 2023.
16.	Masamitsu Ohshima : 歯・歯周組織の包括的再生技術の開発と実用化に向けた展開, 第77回日本口腔科学会学術集会, May 2023.
17.	蓮池真由子, Miho Inoue, RAMAN SWARNA LAKSHMI, Jaime M.Fabillar, Lutfi P.Perdana, Mayu Miyagi, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka : 口腔顔面痛モデル動物を用いた精油嗅覚刺激の疼痛抑制効果∼ベルガモット，ラベンダーの検討∼, Shikoku Dental Research, Mar. 2023.
18.	Jr.M.Fabillar Jaime, Raman Swarna, P.Perdana Lutfi, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : Bilateral transport of neuronal tracer after unilateral administration, 徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
19.	Miho Inoue, RAMAN SWARNA LAKSHMI, FABILLAR JR. JAIME MORENO, 蓮池真由子, PERDANA LUTFI PUTRA, 井上正久, Daisuke Ikutame, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka : 精油成分による口腔顔面痛モデル動物の痛み軽減とメカニズム, 徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
20.	Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸板東, C. Riquelme, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, 新開みずき and Yoshizo Matsuka : デジタル化が進む歯科診療の現状紹介と歯科補綴学実習における学習内容の検討, 大学教育カンファレンスin徳島, Dec. 2022.
21.	Masamitsu Ohshima : 歯周組織の生物学的結合を介した次世代バイオハイブリッドインプラントの開発, 第52回日本口腔インプラント学会学術大会・シンポジウム10, Sep. 2022.
22.	SHINKAI Mizuki, Yoshitaka Suzuki, Kazuo Okura, 加藤隆史, Mayu Miyagi, SHIBAGAKI Akari, Masamitsu Ohshima and Yoshizo Matsuka : 睡眠時ブラキシズムと睡眠嚥下の関連:系統的レビュー, 日本補綴歯科学会中四国支部学術大会, Aug. 2022.
23.	Toyoko Tajima, Maki Hosoki, Miho Inoue, Aya Ozawa, Mizuki Shinkai, Mayu Miyagi, Mio Naritani, Masamitsu Ohshima, 杉尾隆夫, 山本伊一郎 and Yoshizo Matsuka : 徳島大学病院における歯科用金属アレルギー患者の臨床統計学的検討, The Journal of the Japan Prosthodontic Society, Jul. 2022.
24.	SHINKAI Mizuki, Maki Hosoki, Yoshitaka Suzuki, Toyoko Tajima, Miho Inoue, OZAWA Aya, Yasutomo Yoshihara, Masamitsu Ohshima, 織田英正, 本田常晴 and Yoshizo Matsuka : レジンアレルギーのリスクと歯科治療における対応, The Journal of the Japan Prosthodontic Society, Jul. 2022.
25.	Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, Toyoko Tajima, Yasutomo Yoshihara, Aya OZAWA, SHINKAI Mizuki and Yoshizo Matsuka : 歯科補綴学におけるアクティブラーニングの学修効果反転授業とTBL，通常授業の比較, The Journal of the Japan Prosthodontic Society, Jul. 2022.
26.	Masamitsu Ohshima : 顎口腔領域と連携機能する生物学的な再生補綴歯科技術の開発, 第131回日本補綴歯科学会学術大会・イブニングセッション4, Jul. 2022.
27.	Raman Swarna Lakshmi, Waskitho Arief, Kazuo Okura, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka : Evaluation of tetrahydrobiopterin pathway in orofacial pain model, Feb. 2022.
28.	Waskitho Arief, Yumiko Yamamoto, Raman Swarna Lakshmi, Fumiya Kano, Huijiao Yan, Kazuo Okura, Daisuke Ikutame, Masamitsu Ohshima, Otto Baba, Akihito Yamamoto and Yoshizo Matsuka : Bilateral botulinum toxin type A effect on orofacial neuropathic pain of animal model, 徳島大学脳科学クラスターミニリトリート, Feb. 2022.
29.	Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Yasutomo Yoshihara, SHINKAI Mizuki, OZAWA Aya and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―オンライン授業と通常授業，TBL授業の比較―, 大学教育カンファレンス in 徳島, Jan. 2022.
30.	Maki Hosoki, Yasufumi Nishikawa, Daisuke Ikutame, Masamitsu Ohshima, Miho Inoue, Aya OZAWA, SHINKAI Mizuki, RAMAN SWARNA LAKSHMI, CHAVAN PARIMAL RAVINDRA, Yasutomo Yoshihara, Kazuo Okura, Yoshitaka Suzuki and Yoshizo Matsuka : COVID-19対策が日常となった2021年度歯科補綴学実習の評価, 大学教育カンファレンス in 徳島, Jan. 2022.
31.	Masamitsu Ohshima, Raju Resmi, Yan Huijiao and Yoshizo Matsuka : 細胞シート工学技術を利用した複合組織の三次元構築による歯・歯周組織の包括的再生, 細胞シート工学フォーラム, Nov. 2021.
32.	Maki Hosoki, Yuehui Zhang, Toyoko Tajima, Miho Inoue, 井上正久, Masamitsu Ohshima, Mayu Miyagi and Yoshizo Matsuka : モデルマウスによるチタンアレルギーの検討, Journal of the Japanese Association for Dental Science, Sep. 2021.
33.	Yasutomo Yoshihara, Yoshitaka Suzuki, Kazuo Okura, Shuji Shigemoto, Susumu Abe, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Eiichi Bando and Yoshizo Matsuka : 顎運動を伴うRMMAの三次元顎運動解析を行った症例, The Journal of the Japan Prosthodontic Society, Jun. 2021.
34.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷美緒, Miho Inoue and Yoshizo Matsuka : 金属アレルギー患者群と健常者群における特異的マイクロRNAの同定, The Journal of the Japan Prosthodontic Society, Jun. 2021.
35.	Masamitsu Ohshima, Raju Resmi, Yan Huijiao, Miho Inoue and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織立体形成による歯周組織再生技術の開発, 第20回日本再生医療学会総会, Mar. 2021.
36.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Maningo Rodis, Junhel Dalanon, Raju Resmi and Yoshizo Matsuka : 補綴学授業における反転授業とTBLの学修効果に関する比較, Shikoku Dental Research, Feb. 2021.
37.	Masamitsu Ohshima, Raju Resmi, Yan Huijiao, Miho Inoue and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織立体形成による歯周組織再生技術の開発, 日本再生医療学会, Feb. 2021.
38.	Maki Hosoki, Kazuo Okura, Masamitsu Ohshima, Yasufumi Nishikawa, Raju Resmi, OZAWA Aya, SHINKAI Mizuki, Arief Waskitho, RAMAN SWARNA LAKSHMI, CHAVAN PARIMAL RAVINDRA, Miho Inoue, Yoshitaka Suzuki, 吉原靖智 and Yoshizo Matsuka : 歯科補綴学実習における新型コロナウイルス感染症対策について, 大学教育カンファレンス in 徳島, Jan. 2021.
39.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Miho Inoue, Yasutomo Yoshihara and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―オンライン授業とTBL授業の比較―, 大学教育カンファレンス in 徳島, Jan. 2021.
40.	Yan Huijiao, Raju Resmi, Masamitsu Ohshima and Yoshizo Matsuka : 3-dimentional pulp-dentin tissue regeneration by composite cell sheet technology, 徳島大学発生・再生・遺伝クラスターミニリトリート, Dec. 2020.
41.	Masamitsu Ohshima, Raju Resmi, Miho Inoue, Mayu Miyagi and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織形成による三次元組織再生技術の開発, 公益社団法人日本補綴歯科学会第129回学術大会, Jun. 2020.
42.	Takuma Iwasa, Miho Inoue, Raju Resmi, Masamitsu Ohshima and Yoshizo Matsuka : IL-10は神経障害性疼痛を抑制する, The Journal of the Japan Prosthodontic Society, Jun. 2020.
43.	Masamitsu Ohshima : 生物学的な歯周組織再生とその応用による次世代バイオインプラント技術の開発, 第19回日本再生医療学会総会・シンポジウム31, May 2020.
44.	Maki Hosoki, Zhang Yuehui, Masamitsu Ohshima, Miho Inoue, Mio Naritani, Mayu Miyagi and Yoshizo Matsuka : 血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明, Journal of the Japanese Association for Dental Science, Vol.39, 58, Mar. 2020.
45.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Marianito, Takuma Iwasa and Yoshizo Matsuka : 補綴学授業におけるアクティブラーニングによる学修効果-反転授業とTBLの長期比較-, 徳島県歯科医学大会, Feb. 2020.
46.	Takuma Iwasa, Afroz Shaista, Miho Inoue, Rieko Arakaki, Masamitsu Ohshima, Raju Resmi, Arief Waskitho, 井上正久, Otto Baba and Yoshizo Matsuka : 痛みに対するサイトカイン療法の開発に向けて, 徳島県歯科医学大会, Feb. 2020.
47.	Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月皆人, 吉原靖智, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Waskitho Arief, Ofuchi R.S., Masamitsu Ohshima, Yoshitaka Suzuki, 成谷美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka : 歯科補綴学(Ⅱ)実習における実習書改定後の検討, 大学教育カンファレンスin徳島, Dec. 2019.
48.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―反転授業とTBL，通常授業の比較―, 大学教育カンファレンスin徳島, Dec. 2019.
49.	Waskitho Arief, Yamamoto Yumiko, Tsuyoshi Morita, Yan Huijiao, Raju Resmi, Masamitsu Ohshima, Dalanon Junhel, Otto Baba and Yoshizo Matsuka : Orofacial neuropathic pain rat models induced by chemotherapy drugs, Tokushima University Bioscience Retreat, Sep. 2019.
50.	Raju Resmi, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Otto Baba, Inoue Masahisa and Yoshizo Matsuka : Development of a multilayered complex cell sheet to regenerate periodontal tissue, Tokushima University Bioscience Retreat, Sep. 2019.
51.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷美緒, Miho Inoue and Yoshizo Matsuka : 金属アレルギー患者群と健常者群における特異的マイクロRNAの同定, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2019.
52.	成谷美緒, Maki Hosoki, Mayu Miyagi, Masamitsu Ohshima, Miho Inoue, 岩浅匠真 and Yoshizo Matsuka : 金属アレルギー患者に対する血管内治療の術前評価, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2019.
53.	Maki Hosoki, Yuehui Zhang, Masamitsu Ohshima, Miho Inoue, 成谷美緒, Mayu Miyagi and Yoshizo Matsuka : 血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明, 歯科医学を中心とした総合的な研究を推進する集い, Aug. 2019.
54.	Raju Resmi, Masamitsu Ohshima, Miho Inoue, Tsuyoshi Morita, Yan Huijiao, Otto Baba, 井上正久 and Yoshizo Matsuka : 骨芽細胞と歯根膜細胞との立体形成複合細胞シートによる歯周組織再生の確立, 硬組織再生生物学会, Aug. 2019.
55.	Miho Inoue, Raju Resmi, Takuma Iwasa, 秋山謙太郎, Masamitsu Ohshima, 窪木拓男 and Yoshizo Matsuka : 抗Dickkopf1 (DKK-1) 抗体による骨分化能メカニズムの解明, The Journal of the Japan Prosthodontic Society, May 2019.
56.	Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月皆人, Yasutomo Yoshihara, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Arief Waskitho, Rodrigo Shigeru Ofuchi, Masamitsu Ohshima, Yoshitaka Suzuki, 成谷美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka : 歯科補綴学(Ⅱ)実習における実習書改定後の検討in徳島, 大学教育カンファレンス, Dec. 2018.
57.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 岩浅匠真, Junhel Dalanon and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果-反転授業とTBLの比較-, 大学教育カンファレンスin徳島, Dec. 2018.
58.	Maki Hosoki, Mayu Miyagi, Miho Inoue, Kazuo Okura, Masamitsu Ohshima, Raju Resmi, 岩浅匠真, 成谷美緒, Zhang Yuehui, Yan Huijiao, Arief Waskitho, Junhel Dalanon, Yoshitaka Suzuki, 吉原靖智 and Yoshizo Matsuka : 歯科補綴学実習における実習書の改訂とその効果の検討, 大学教育カンファレンスin徳島, Dec. 2018.
59.	Masamitsu Ohshima : 生理的な歯周組織構造を有する次世代バイオハイブリッドインプラントの開発, 第22回公益社団法人日本顎顔面インプラント学会総会・学術大会, Dec. 2018.
60.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, Mio Naritani and Yoshizo Matsuka : 金属アレルギーに関する特異的遺伝子の検討, 日本補綴歯科学会関西支部学術大会, Dec. 2018.
61.	Masamitsu Ohshima : 歯周組織の構造・機能を包括的に再生するバイオハイブリッドインプラントの開発, 第60回歯科基礎医学会学術大会アップデートシンポジウム, Sep. 2018.
62.	Haruka Matsuda, Yoshitaka Suzuki, Kouhei Kamoi, Toshinori Okawa, Yasutomo Yoshihara, Kazuo Okura, Masamitsu Ohshima, Susumu Abe, 池田隆志, Eiji Yamauchi, Fumiaki Kawano and Yoshizo Matsuka : レジンブロックの三次元計測方法の違いによる寸法精度の比較, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2018.
63.	川原博雄, Miho Inoue, Masamitsu Ohshima, Kazuo Okura, Maki Hosoki, Toyoko Tajima and Yoshizo Matsuka : 一般歯科診療所での長期メインテナンス患者における歯の喪失原因の評価, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2018.
64.	Raju Resmi, Miho Inoue, 宮城麻友, 秋山謙太郎, Masamitsu Ohshima, 井上正久 and Yoshizo Matsuka : 抗Dickkopf1 (DKK-1) 抗体による骨髄細胞の骨分化能への影響, 硬組織再生生物学会, Aug. 2018.
65.	Miho Inoue, Raju Resmi, Masamitsu Ohshima, 梶本昇, 都留寛治, 石川邦夫, 井上正久 and Yoshizo Matsuka : Tumor necrosis factor (TNF)-α処理炭酸アパタイトおよびハイドロキシアパタイトが骨形成におよぼす影響, 硬組織再生生物学会, Aug. 2018.
66.	岩浅匠真, Afroz Shaista, Casinilo Junhel Dalanon, Masamitsu Ohshima, Kazuo Okura, Miho Inoue and Yoshizo Matsuka : 三叉神経痛モデルラットにおける炎症性サイトカインの変動解析, 日本顎関節学会・日本口腔顔面痛学会・日本歯科心身医学会, Jul. 2018.
67.	松田はるか, Yoshitaka Suzuki, Kouhei Kamoi, Toshinori Okawa, 吉原靖智, Soh Yasuda, Kazuo Okura, Masamitsu Ohshima, Susumu Abe, 富永賢, Fumiaki Kawano and Yoshizo Matsuka : レジン片の3次元測定方法による寸法精度の比較, Shikoku Dental Research, Jul. 2018.
68.	Gantumur Chimeddulam, Keisuke Nishigawa, Yoshihito Naitou, Junhel Dalanon, Afroz Shaista, 葉山莉香, Masamitsu Ohshima, Yoritoki Tomotake, Tetsuo Ichikawa and Yoshizo Matsuka : インプラントシステムの違いによるインプラント周囲骨吸収に関する長期放射線学的検討, The Journal of the Japan Prosthodontic Society, Jun. 2018.
69.	Yasutomo Yoshihara, Yoshitaka Suzuki, Keisuke Nishigawa, 宮城麻友, Kazuo Okura, Susumu Abe, Maki Hosoki, Masamitsu Ohshima, Fumiaki Kawano and Yoshizo Matsuka : 徳島大学歯学部学生における咬耗に関連した行動因子による咬合接触の変化, The Journal of the Japan Prosthodontic Society, Jun. 2018.
70.	Kouhei Kamoi, Yoshitaka Suzuki, Kazuo Okura, 宮城麻友, Miho Inoue, Masamitsu Ohshima, Yuji Shimizu and Yoshizo Matsuka : ナイトガードの咬耗面を3次元画像解析装置にて定量評価した症例, Shikoku Dental Research, Mar. 2018.
71.	Masamitsu Ohshima : 歯の生理機能を包括的に再生可能な次世代バイオハイブリッドインプラントの開発, 日本歯科理工学会近畿・中四国地方会, Jan. 2018.
72.	Kazuo Okura, Keisuke Nishigawa, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, 宮城麻友, Miho Inoue, Takuma Iwasa, Rika Hayama and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの効果 ―反転授業とTBLの比較―, 教育カンファレンスin徳島, Dec. 2017.
73.	Masamitsu Ohshima : 顎口腔領域と連携機能する生物学的な歯の再生治療の技術開発, 第9回日本メタルフリー歯科学会学術大会, Nov. 2017.
74.	S Afroz, Iwasa Takuma, Masamitsu Ohshima, Rieko Arakaki, Miho Inoue, Naozumi Ishimaru and Yoshizo Matsuka : Cytokine released by satellite glial cells and pain transmission in sensory ganglions, Japan Association for Dental Research, Nov. 2017.
75.	Hiroh Kawahara, Miho Inoue, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka : 長期的メインテナンス患者における歯の喪失に関する後ろ向き調査, The Journal of Japan Association of Oral Rehabilitation, Nov. 2017.
76.	Takuma Iwasa, S. Afroz, Mio Naritani, 宮城麻友, Miho Inoue, Masamitsu Ohshima and Yoshizo Matsuka : 神経障害性痛モデルラットに対するボツリヌス毒素の効果, 日本ボツリヌス治療学会, Sep. 2017.
77.	Masamitsu Ohshima : 歯・歯周組織を包括的に再生可能な歯科再生医療の技術開発, 第127回大阪口腔インプラント研究会, Sep. 2017.
78.	野田千織, Rika Hayama, Susumu Abe, Kazuo Okura, 本田常晴, 杉尾隆夫, Fumiaki Kawano, Masamitsu Ohshima and Yoshizo Matsuka : 女性歯科医師の幸福度調査, 日本補綴歯科学会中国・四国支部学術大会, Aug. 2017.
79.	Raju Resmi, Miho Inoue, Mio Naritani, 宮城麻友, 織田英正, 友永泰弘, Masamitsu Ohshima and Yoshizo Matsuka : 骨髄由来間葉系細胞におけるTNF-α短期刺激による細胞動態の解析, 日本補綴歯科学会中国四国支部学術大会, Aug. 2017.
80.	Miho Inoue, Mio Naritani, R. Raju, 宮城麻友, Y. Zhang, Masamitsu Ohshima, 井上正久 and Yoshizo Matsuka : 骨髄細胞，骨芽細胞様細胞におけるTNF-α短期間刺激による細胞挙動の解析, 日本硬組織再生生物学会, Aug. 2017.
81.	Takuma Iwasa, Masamitsu Ohshima, Kazuo Okura, Miho Inoue, S. Afroz and Yoshizo Matsuka : 口腔顎顔面痛モデル三叉神経節におけるサイトカイン動態, Japanese Journal of Orofacial Pain, Jul. 2017.
82.	Daiki Teruya, Miho Inoue, Mio Naritani, R. Raju, 宮城麻友, Masamitsu Ohshima and Yoshizo Matsuka : 骨髄細胞，骨芽細胞様細胞におけるTNF-α短期刺激による細胞学的・組織学的検討, The Journal of the Japan Prosthodontic Society, Jul. 2017.
83.	Masamitsu Ohshima : 歯科再生医療の実現に向けた器官再生技術の開発, 第51回四国歯学会例会, Jun. 2017.
84.	Daiki Teruya, Miho Inoue, Mio Naritani, R. Raju, 宮城麻友, Masamitsu Ohshima and Yoshizo Matsuka : TNF-α短期刺激による骨髄細胞の細胞学的検討, Shikoku Dental Research, Jun. 2017.
85.	Masamitsu Ohshima : 未来の歯科再生医療の実現に向けた器官再生技術の開発, スタディグループ日曜会第300回例会, Mar. 2017.

Et cetera, Workshop:

1.	Lutfi P. Perdana, Swarnalakshmi Raman, Jaime Jr. Fabillar, Dara S. Arini, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka : Antinociceptive mechanism of IL-10 in trigeminal ganglia of trigeminal neuropathic pain model, Feb. 2024.
2.	Raju Resmi, Masamitsu Ohshima, Tsuyoshi Morita, Yan Huijiao, Miho Inoue, Otto Baba, Inoue Masahisa and Yoshizo Matsuka : Three-dimensional periodontal tissue regeneration using a bone-ligament complex cell sheet, 発生・再生・遺伝クラスターミニリトリート, Feb. 2020.
3.	Dalanon Junhel, Sachiko Chikahisa, Noriyuki Shimizu, Waskitho Arief, Chavan Parimal, Lakshmi Swarna, Hiroyoshi Sei, Masamitsu Ohshima and Yoshizo Matsuka : The effect of predictable chronic mild stress on sleep quality and nociception, 徳島大学脳科学クラスターミニリトリート, Feb. 2020.
4.	Waskitho Arief, Yumiko Yamamoto, Tsuyoshi Morita, Yan Huijiao, Raju Resmi, Masamitsu Ohshima, Dalanon Junhel, Laksmi Swarna, Chavan P., Otto Baba and Yoshizo Matsuka : Botulinum toxin A administration in chemotherapy-induced neuropathic pain rat model, 徳島大学脳科学クラスターミニリトリート, Feb. 2020.
5.	Masamitsu Ohshima : 器官発生メカニズムに立脚した三次元的細胞操作技術による器官再生技術の開発, 第3回口腔医科学フロンティア研究会, Mar. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

唾液中miRNAの探索による金属アレルギーの病態解明と新たな検査法の確立 (Project/Area Number: 24K13027 )
BH4 pathway and formation of a foundation for novel therapies for orofacial pain (Project/Area Number: 23K24539 )
Analysis of molecular mechanisms of organ size and morphogenesis for dental regenerative medicine (Project/Area Number: 22K10079 )
Elucidate of mechanism of orofacial pain through pain reduction using essential oils in neuropathic pain animal model (Project/Area Number: 22K10060 )
microRNAを用いた金属アレルギーによる口腔扁平苔癬の新規診断マーカーの確立 (Project/Area Number: 21K10022 )
Establishment of the new diagnosis biomarkers for metal allergy by analyzing peripheral blood miRNA expression (Project/Area Number: 20K10038 )
Development of a bio-artificial tooth root based on the mechanism for periodontal tissue formation and maturation by using occlusal stress. (Project/Area Number: 19K10208 )
Neuron-glia signal processing for orofacial pain management development (Project/Area Number: 18H02992 )
Understanding of periodontal disease and peri-implantitis with stem cell disfunction (Project/Area Number: 17H04392 )
Search of master regulator of odontoblastogenesis using iPS interference (Project/Area Number: 16K15802 )
The development of bone regeneration therapy based on the clarification of mechanism of BMP-2 induced bone formation and resorption (Project/Area Number: 16H05524 )
Maintenance of undifferentiated state of mesenchymal stem cells using amino acids for the regulation of stem cell aging (Project/Area Number: 15K15708 )
Identification of master genes for regulating developmental time in regenerated organs (Project/Area Number: 15K15707 )
Guided control of keratinized epithelial mucosa as a next generation periodontal soft tissue regeneration (Project/Area Number: 15H05026 )
Development of tissue regeneration therapy using host stem cell homing (Project/Area Number: 26713053 )
Therapeutic effect of human dental pulp stem cell on Experimental autoimmune encephalomyelitis. (Project/Area Number: 26670837 )
Development of tooth regeneration technology based on the clarification of mechanism of tooth development. (Project/Area Number: 26253088 )
Establishment of the splitting tooth germ method for realization of tooth germ transplantation therapy. (Project/Area Number: 25670835 )
Development of technologies for next-generation regenerative therapies (Project/Area Number: 25242041 )
Human dental pulp stem cell ameliorate Experimental autoimmune encephalomyelitis. (Project/Area Number: 24890135 )
A development of the comprehensive tooth regenerative therapy by the bioengineered tooth unit transplantation. (Project/Area Number: 22791941 )
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Associate Professor : Ohshima, Masamitsu

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)