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Tokushima UniversityGraduate School of Biomedical Sciences医学域先端臨床医学教育研究プロジェクト
Tokushima UniversityGraduate School of Biomedical Sciences医学域Medical ScienceSurgeryDepartment of Neurosurgery
Tokushima UniversityResearch ClustersResearch Clusters (Prioritized)1903001 次世代型「脳関門創薬」拠点形成:ヒト血液脳関門物流システム解明に基づく脳関門突破型抗体・核酸医薬の開発
Tokushima UniversityUniversity HospitalClinical DivisionDepartment of Neurosurgery, Psychiatry and AnesthesiologyNeurosurgery
Tokushima UniversityFaculty of MedicineSchool of MedicineCourse of Integrated Brain SciencesNeurosurgery
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Academic Paper (Judged Full Paper):

1. Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi :
Seizure types associated with negative arterial spin labeling and positive diffusion-weighted imaging on peri-ictal magnetic resonance imaging,
Journal of the Neurological Sciences, Vol.436, 1-8, 2022.
(DOI: 10.1016/j.jns.2022.120223,   PubMed: 35279594,   Elsevier: Scopus)
2. Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Mai Azumi and Yasushi Takagi :
Development of a Navigation-guided Fence-post Catheter for Brain Tumor Resection,
The Journal of Medical Investigation : JMI, Vol.69, No.1,2, 117-119, 2022.
(Tokushima University Institutional Repository: 117022,   DOI: 10.2152/jmi.69.117,   PubMed: 35466132,   Elsevier: Scopus)
3. Kenji Shono, Yoshifumi Mizobuchi, Izumi Yamaguchi, Kohhei Nakajima, Yuri Fujiwara, Toshitaka Fujihara, Keiko Kitazato, Kazuhito Matsuzaki, Yoshihiro Uto, Oltea Sampetrean, Hideyuki Saya and Yasushi Takagi :
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.,
Scientific Reports, Vol.11, No.1, 2021.
(Tokushima University Institutional Repository: 116448,   DOI: 10.1038/s41598-021-93896-0,   PubMed: 34301977)
4. Kenji Shimada, Yoko Yamamoto, Takeshi Miyamoto, Shu Sogabe, Toshitaka Fujihara, Kohhei Nakajima, Yoshifumi Mizobuchi, Yasuhisa Kanematsu and Yasushi Takagi :
Efficacy of Intra-arterial Indocyanine Green Videoangiography in Hemangioblastoma Surgery: A Case Report.,
NMC Case Report Journal, Vol.8, No.1, 295-300, 2021.
(DOI: 10.2176/nmccrj.cr.2020-0281,   PubMed: 35079478)
5. Kohhei Nakajima, Yoshifumi Mizobuchi, Toshitaka Fujihara, Mai Azumi and Yasushi Takagi :
Continued-Maintenance Therapy with High-dose Methotrexate Improves Overall Survival of Patients with Primary Central Nervous System Lymphoma.,
The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 286-291, 2021.
(Tokushima University Institutional Repository: 116496,   DOI: 10.2152/jmi.68.286,   PubMed: 34759146)
6. Kenji Shono, Izumi Yamaguchi, Yoshifumi Mizobuchi, Hiroshi Kagusa, Akiko Sumi, Toshitaka Fujihara, Kohhei Nakajima, T Keiko Kitazato, Kazuhito Matsuzaki, Hideyuki Saya and Yasushi Takagi :
Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma.,
Scientific Reports, Vol.10, No.1, 2020.
(Tokushima University Institutional Repository: 117722,   DOI: 10.1038/s41598-020-71857-3,   PubMed: 32943658)
7. Hiroshi Kagusa, Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Yoshimi Bando and Yasushi Takagi :
Metastatic tumor to the orbital cavity from a primary carcinoma of the uterine cervix : a case report.,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 355-357, 2019.
(Tokushima University Institutional Repository: 114169,   DOI: 10.2152/jmi.66.355,   PubMed: 31656305)
8. Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Kazuhito Matsuzaki, Hideo Mure, Shinji Nagahiro and Yasushi Takagi :
The risk of hemorrhage in stereotactic biopsy for brain tumors.,
The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 314-318, 2019.
(Tokushima University Institutional Repository: 114088,   DOI: 10.2152/jmi.66.314,   PubMed: 31656296)
9. Toshitaka Fujihara, Yoshifumi Mizobuchi, Kohhei Nakajima, Teruyoshi Kageji, Kazuhito Matsuzaki, KT Kitazato, Ryotaro Otsuka, Keijiro Hara, Hideo Mure, Toshiyuki Okazaki, Kazuyuki Kuwayama, Shinji Nagahiro and Yasushi Takagi :
Down-regulation of MDR1 by Ad-DKK3 via Akt/NFB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model,
Journal of Neuro-Oncology, Vol.139, No.2, 323-332, 2018.
(Tokushima University Institutional Repository: 112895,   DOI: 10.1007/s11060-018-2894-5,   PubMed: 29779087,   Elsevier: Scopus)
10. Aya Sato, Yoshifumi Mizobuchi, Kohhei Nakajima, Kenji Shono, Toshitaka Fujihara, Teruyoshi Kageji, Keiko Kitazato, Kazuhito Matsuzaki, Hideo Mure, Kazuyuki Kuwayama, Akiko Sumi, Hideyuki Saya, Oltea Sampetrean and Shinji Nagahiro :
Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.,
Journal of Neuro-Oncology, Vol.132, No.2, 231-238, 2017.
(Tokushima University Institutional Repository: 115523,   DOI: 10.1007/s11060-017-2380-5,   PubMed: 28283800)

Proceeding of International Conference:

1. Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Nobuaki Yamamoto, Hiroki Yamazaki, Yuishin Izumi, Masafumi Harada, Yasuhisa Kanematsu and Yasushi Takagi :
Peri-ictal normal arterial spin labeling imaging in patients with seizures,
13 回アジア・オセアニアてんかん学会(13th AOEC), Jun. 2021.
2. Kenji Shono, Izumi Yamaguchi, Toshitaka Fujihara, Keiko Kitazato, Kohhei Nakajima, Yoshifumi Mizobuchi, Hideo Mure, Kohhei Nakajima, Junichiro Satomi, Shinji Nagahiro and Yasushi Takagi :
Celecoxib inhibits proliferation and induces apoptosis in glioma stem cells and an animal model of glioblastoma.,
22ND ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE SOCIETY FOR NEURO-ONCOLOGY, San Francisco, Nov. 2017.
3. Junichiro Satomi, Yasuhisa Kanematsu, Masaaki Korai, Yuki Yamamoto, Nobuaki Yamamoto, Yoshifumi Mizobuchi, Hideo Mure, Yoshiteru Tada, Kohhei Nakajima, Toshiyuki Okazaki and Toshitaka Fujihara :
Acute stroke management using image sharing on smart phones and tablet devices,
14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.

Proceeding of Domestic Conference:

1. Yoshiteru Tada, Masahito Nakataki, Tatsuo Mori, Toshitaka Fujihara, Aya Gohji, Hiroki Yamazaki, 泉 千恵, 高尾 里沙, 多田 雅美, 阿部 修司, Kenji Mori and Yasushi Takagi :
地方におけるてんかん支援拠点病院の役割,
第10回全国てんかんセンター協議会, Feb. 2023.
2. Toshitaka Fujihara, Yoshiteru Tada and Yasushi Takagi :
てんかん外科へのアクセス困難な地域における診療支援,
第10回全国てんかんセンター協議会, Feb. 2023.
3. Yoshiteru Tada, Toshitaka Fujihara, 板東 康司, 山本 陽子 and Yasushi Takagi :
Five cases of vagus nerve stimulation for drug-resistant status epilepticus,
第46回日本てんかん外科学会, Jan. 2023.
4. Toshitaka Fujihara, Yoshiteru Tada, 板東 康司 and Yasushi Takagi :
An effective case of posterior quadrantectomy for drug resistant epilepsy after brain tumor surgery,
第46回 日本てんかん外科学会, Jan. 2023.
5. Mai Azumi, Toshitaka Fujihara, Keijiro Hara, Kohhei Nakajima, Yoshifumi Mizobuchi and Yasushi Takagi :
Examination about the predictors of outcome at discharge in postoperative brain tumor patients admitted to the intensive care units,
日本脳神経外科学会第81回学術総会, Sep. 2022.
6. Yoshiteru Tada, Toshitaka Fujihara, Kenji Shimada, Yasuhisa Kanematsu and Yasushi Takagi :
Seizure types associated with finding of arterial spin labeling and diffusion-weighted imaging,
第55回日本てんかん学会学術集会, Sep. 2022.
7. Keijiro Hara, Yoshifumi Mizobuchi, Mai Azumi, Shu Sogabe, Toshitaka Fujihara, Kohhei Nakajima and Yasushi Takagi :
Hyper vascularityを呈した松果体部腫瘍の1例,
Apr. 2022.
8. 平野 愛子, 北村 愛里, 重根 裕代, 川原 みゆき, Toshitaka Fujihara, Yoshiteru Tada, Kenji Mori and Yasushi Takagi :
長時間ビデオ脳波モニタリング実施時の発作時観察力向上のための取り組み∼発作観察時のビデオ作成 発作時対応のシミュレーションの実施∼.,
, Mar. 2022.
9. 高尾 里沙, 多田 雅美, 安部 修司, Masahito Nakataki, Tatsuo Mori, Toshitaka Fujihara, Yoshiteru Tada, Hiroki Yamazaki and Kenji Mori :
てんかん相談における徳島県の現状の把握と今後の課題.,
第9回 全国てんかんセンター協議会総会 鹿児島大会, Mar. 2022.
10. Yoshiteru Tada, Masahito Nakataki, Tatsuo Mori, Toshitaka Fujihara, Aya Gohji, Hiroki Yamazaki, 高尾 里沙, 泉 千恵, 多田 雅美, 安部 修司 and Kenji Mori :
今後の徳島県におけるてんかん地域診療連携整備事業の展望について,
第9回全国てんかんセンター協議会総会, Mar. 2022.
11. Yasuhisa Kanematsu, Toshitaka Fujihara, Kenji Shimada, Yoshiteru Tada and Yasushi Takagi :
外傷性内頚動脈海綿静脈洞瘻による静脈環流障害から非けいれん性てんかん重積をきたした一例,
第45回日本脳神経外傷学会, Feb. 2022.
12. Toshitaka Fujihara, Yoshiteru Tada, 片桐 匡弥, 香川 幸太, 飯田 幸治 and Yasushi Takagi :
比較的長時間持続する両側口角のけいれんを主とする薬剤抵抗性てんかんに対し迷走神経刺激療法を施行した1例,
第16回 日本てんかん学会 中国・四国地方会, Feb. 2022.
13. Toshitaka Fujihara, Yoshiteru Tada and Yasushi Takagi :
Vegas nerve stimulation revision at pulse generator re-implantation; a case report,
The 45th Annual Meeting of Epilepsy Surgery Society of Japan, Jan. 2022.
14. Yoshiteru Tada, Toshitaka Fujihara, Yoshihiro Tsuruo, 飯田 幸治 and Yasushi Takagi :
Surgical training for hemispherectomy using fresh frozen cadavers,
第45回日本てんかん外科学会, Jan. 2022.
15. Toshitaka Fujihara, Yoshiteru Tada, Yoshifumi Mizobuchi, Kohhei Nakajima, Keijiro Hara, Mai Azumi and Yasushi Takagi :
Epilepsy and perioperative seizure management in surgical cases of supratentorial meningioma,
日本脳神経外科学会 第80回学術総会, Oct. 2021.
16. Yoshiteru Tada, Toshitaka Fujihara, Yoshihiro Tsuruo and Yasushi Takagi :
Surgical training for epilepsy surgery using fresh frozen cadavers,
NMC Case Report Journal, Oct. 2021.
17. Kohhei Nakajima, Yoshifumi Mizobuchi, Toshitaka Fujihara, Mai Azumi and Yasushi Takagi :
中枢神経原発悪性リンパ腫に対する大量メトトレキサート維持療法の意義,
NMC Case Report Journal, Oct. 2021.
18. Mai Azumi, Takeshi Miyamoto, Toshitaka Fujihara, Kohhei Nakajima, Keijiro Hara, Yoshifumi Mizobuchi and Yasushi Takagi :
特発性頭蓋内圧亢進様の症状のみで発症した小児脳腫瘍の1例,
第35回中国四国脳腫瘍研究会, Sep. 2021.
19. Yoshiteru Tada, Toshitaka Fujihara, Yoshihiro Tsuruo, 飯田 幸治 and Yasushi Takagi :
Surgical training for hemispherectomy using fresh frozen cadavers,
第54回日本てんかん学会学術集会, Sep. 2021.
20. Yoshiteru Tada, Toshitaka Fujihara, Yuichi Satoh, 飯田 幸治 and Yasushi Takagi :
2期的に半球離断術を施行した成人片側巨脳症の1例,
第15回日本てんかん学会中国・四国地方会, Feb. 2021.
21. Toshitaka Fujihara, Yoshiteru Tada, Kenji Shimada, Yasuhisa Kanematsu and Yasushi Takagi :
内頚動脈海綿静脈洞瘻に急性症候発作重積を合併した1例,
第14回日本てんかん学会中国・四国地方会, Feb. 2020.
22. Toshitaka Fujihara, Yoshiteru Tada, Mai Azumi and Yasushi Takagi :
海馬からのてんかん性放電が乏しかった海馬硬化症の1例,
第7回全国てんかんセンター協議会広島大会, Feb. 2020.
23. Yoshiteru Tada, Yoshihiro Touda, Masahito Nakataki, Toshitaka Fujihara, 森 達夫, Aya Gohji, 飯田 幸治, Kenji Mori and Yasushi Takagi :
徳島県におけるてんかん地域診療連携整備事業の活動状況,
第7回全国てんかんセンター協議会広島大会, Feb. 2020.
24. Yoshiteru Tada, Toshitaka Fujihara, 香川 幸太, 片桐 匡弥, 瀬山 剛, 飯田 幸治 and Yasushi Takagi :
遠隔てんかん症例検討会による薬剤抵抗性側頭葉てんかん治療方針の決定について,
第43回日本てんかん外科学会, Jan. 2020.
25. Toshitaka Fujihara, Yoshiteru Tada, Yasuhisa Kanematsu and Yasushi Takagi :
Wadatestにて言語優位半球を同定できなかった薬剤抵抗性側頭葉てんかんの一例,
第43回日本てんかん外科学会, Jan. 2020.
26. Masahito Nakataki, Hiroaki Edo, Yoshiteru Tada, Yoshihiro Touda, Toshitaka Fujihara, Tatsuo Mori, Aya Gohji, Kenji Mori and Tetsuro Ohmori :
てんかん発作や精神症状と関連しない生活の質,
第53回日本てんかん学会学術集会, Nov. 2019.
27. Toshitaka Fujihara, Yoshiteru Tada, Yoshifumi Mizobuchi, Kohhei Nakajima, Mai Azumi and Yasushi Takagi :
脳腫瘍手術における周術期抗てんかん薬使用と術後発作抑制効果についての検討,
第53回日本てんかん学会学術集会, Oct. 2019.
28. Yoshiteru Tada, Yoshihiro Touda, Masahito Nakataki, Toshitaka Fujihara, Tatsuo Mori, Aya Gohji, 飯田 幸治, Kenji Mori and Yasushi Takagi :
徳島県におけるてんかん地域診療連携整備事業の紹介,
第53回日本てんかん学会学術集会, Oct. 2019.
29. Hiroshi Kagusa, Yoshifumi Mizobuchi, Toshitaka Fujihara, Kohhei Nakajima and Yasushi Takagi :
眼窩内に転移した子宮頚癌の1例,
日本脳神経外科学会第78回学術集会, Oct. 2019.
30. Kohhei Nakajima, Toshitaka Fujihara, Yoshifumi Mizobuchi and Yasushi Takagi :
当院における転移性脳腫瘍に対する術後放射線療法の検討,
日本脳神経外科学会第78回学術集会, Oct. 2019.
31. Yoshiteru Tada, Toshitaka Fujihara, Kohhei Nakajima, Mai Azumi and Yasushi Takagi :
高齢発症てんかんの臨床的特徴,
日本脳神経外科学会第78回学術集会, Oct. 2019.
32. Toshitaka Fujihara, Yoshifumi Mizobuchi, Kohhei Nakajima, Mai Azumi, Yoshiteru Tada and Yasushi Takagi :
Perioperative prophylactic antiepileptic drug use and postoperative seizure in brain tumor surgery,
Neurologia Medico-Chirurgica, Oct. 2019.
33. Kohhei Nakajima, Toshitaka Fujihara, Yoshifumi Mizobuchi and Yasushi Takagi :
中枢神経原発性悪性リンパ腫に対する大量メトトレキサート維持療法の治療成績,
第36回日本脳腫瘍学会学術集会, Dec. 2018.
34. Kohhei Nakajima, Toshitaka Fujihara, Yoshifumi Mizobuchi and Yasushi Takagi :
穿刺様頭痛で発見された中枢神経アスペルギルス症の1例,
第46回日本頭痛学会総会, Nov. 2018.
35. Yoshiteru Tada, Toshitaka Fujihara, Kohhei Nakajima, Kenji Mori and Yasushi Takagi :
高齢発症てんかんの臨床的特徴,新規抗てんかん薬の効果,
日本脳神経外科学会第77回学術総会, Oct. 2018.
36. Toshitaka Fujihara, Yoshifumi Mizobuchi, Kohhei Nakajima, Toshiyuki Okazaki, Hideo Mure and Yasushi Takagi :
膠芽腫におけるDKK3遺伝子導入による薬剤排泄ポンプの発現抑制の意義,
日本脳神経外科学会第77回学術総会, Oct. 2018.
37. 鹿草 宏, Yoshifumi Mizobuchi, Toshitaka Fujihara, Kohhei Nakajima and Yasushi Takagi :
慢性硬膜下血腫の手術方法の検討,
日本脳神経外科学会第77回学術総会, Oct. 2018.
38. Kohhei Nakajima, Toshitaka Fujihara, Yoshifumi Mizobuchi and Yasushi Takagi :
当院における中枢神経原発悪性リンパ腫に対する大量メトトレキサート維持療法の治療成績,
日本脳神経外科学会第77回学術総会, Oct. 2018.
39. Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Shinji Nagahiro and Yasushi Takagi :
顔面痙攣に対する手術手技 "shelter method" の有効性と長期予後,
日本脳神経外科学会第77回学術総会, Oct. 2018.
40. Shoichi Hatada, 小山 広士, Toshitaka Fujihara, Kohhei Nakajima, Yoshifumi Mizobuchi and Yasushi Takagi :
短期間で出血を繰り返した多発脳病変の1例,
第32回中国四国脳腫瘍研究会, Sep. 2018.
41. Yoshiteru Tada, Toshitaka Fujihara, Aya Gohji, Tatsuo Mori, Yoshihiro Touda, Kenji Mori, 飯田 幸治, Junichiro Satomi and Yasushi Takagi :
術前精査中にバルブロ酸の追加が著効したrolandic crtical dysplasiaに1例,
第41回日本てんかん外科学会, Jan. 2018.
42. Toshitaka Fujihara, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Masafumi Harada, Junichiro Satomi and Shinji Nagahiro :
非痙攣性てんかん重積診断におけるArterial Spin Labeling法の有用性,
第51回日本てんかん学会年次学術集会, Nov. 2017.
43. Toshitaka Fujihara, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Masafumi Harada, Junichiro Satomi and Shinji Nagahiro :
当院で経験した非痙攣性てんかん重積症例の検討,
日本脳神経外科学会 第76回学術総会, Oct. 2017.
44. Toshitaka Fujihara, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, 飯田 幸治 and Shinji Nagahiro :
同側の未破裂中大脳動脈瘤を合併した左海馬硬化症による難治性内側側頭葉てんかんの一例,
第11回てんかん学会中国・四国地方会, Feb. 2017.

Et cetera, Workshop:

1. Tatsuya Haboshi, Yoshiteru Tada, Toshitaka Fujihara, 亘 雄也, Kohhei Nakajima and Yasushi Takagi :
前方脳梁離断術を施行した成人難治性てんかんの2例,
第43回徳島脳神経外科談話会, Dec. 2017.
2. Toshitaka Fujihara, Yoshiteru Tada and Shinji Nagahiro :
当院で経験した非痙攣性てんかん重積症例の検討,
第4回徳島脳神経疾患談話会, Mar. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)