徳島大学 / 教育研究者総覧 --- 上野義豊

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

1.	Raphaël Cinotti, Cesar Julio Mijangos, Paolo Pelosi, Matthias Haenggi, Mohan Gurjar, J Marcus Schultz, Callum Kaye, Agustin Daniel Godoy, Pablo Alvarez, Aikaterini Ioakeimidou, Yoshitoyo Ueno, Rafael Badenes, Ali Elbuzidi Abdurrahmaan Suei, Michaël Piagnerelli, Muhammed Elhadi, Tariq Syed Reza, Atef Mohammed Azab, Victoria McCredie, D Robert Stevens, Catherine Jean Digitale, Nicholas Fong and Karim Asehnoune : Extubation in neurocritical care patients: the ENIO international prospective study., Intensive Care Medicine, Vol.48, No.11, 1539-1550, 2022. (要約) ENIO (NCT03400904) is an international, prospective observational study, in 73 intensive care units (ICUs) in 18 countries from 2018 to 2020. Neurocritical care patients with a Glasgow Coma Score (GCS) ≤ 12, receiving IMV ≥ 24 h, undergoing extubation attempt or tracheostomy were included. The primary endpoint was extubation failure by day 5. An extubation success prediction score was created, with 2/3 of patients randomly allocated to the training cohort and 1/3 to the validation cohort. Secondary endpoints were the duration of IMV and in-ICU mortality. (キーワード) Humans / Airway Extubation / Prospective Studies / Respiration, Artificial / Tracheostomy / Intensive Care Units (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00134-022-06825-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36038713 ● Search Scopus @ Elsevier (PMID): 36038713 ● Search Scopus @ Elsevier (DOI): 10.1007/s00134-022-06825-8 (DOI: 10.1007/s00134-022-06825-8, PubMed: 36038713)
2.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 新井悠太, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 経肺圧を指標としたPEEP設定により，致死的低酸素血症から改善した神経芽細胞種に伴う腹部コンパートメント症候群の一乳児症例, 四国医学雑誌, Vol.2022;78, No.3,4, 115-120, 2022年. (要約) Background : Neuroblastoma is the most common extracranial solid tumor of childhood. Although the prognosis of neuroblastoma is relatively good, newborns less than two months of age with stage 4S neuroblastoma may present with aggressive hypoxia and restrictive respiratory impairment due to abdominal compartment syndrome. Case presentation : Two-month-old girl, height of 63 cm and body weight of 10 kg. She was diagnosed as neuroblastoma with Stage 4S. Because she was suffered from refractory hypoxemia and restrictive respiratory impairment due to abdominal compartment syndrome induced by multiple liver metastasis and massive ascites, she was transferred to our ICU. Her trachea was intubated and ventilated with assist/controlled mode, driving pressure 22 cmH2O, positive end-expiratory pressure(PEEP)8 cmH2O, fraction of inspiratory oxygen(FIO2)1.0, but tidal volume was obtained only 3.2 mL/kg and PaO2/FIO2 ratio of 55 mmHg. Therefore, we insert esophageal sensor and monitored esophageal pressure to performed transpulmonary pressure guided PEEP titration. When we changed PEEP from 8 to 15 cmH2O so that the end-expiratory transpulmonary pressure achieving 0 to 5 cmH2O, her oxygenation(PaO2/FIO2 ratio : 55 to 178 mmHg)and respiratory compliance(1.4 to 3.0 mL/cmH2O)were dramatically improved. Her respiratory condition was further stabilized by ascites puncture and radiotherapy, and the patient was extubated successfully on the 25th ICU day. Conclusions : Although pediatric neuroblastoma with stage 4S may induce severe respiratory efficiency, the responsiveness of treatment for neuroblastoma is promising. Multimodal treatments including optimal ventilator management such as transpulmonary pressure -guided PEEP titration contributes to improved patient's prognosis. (キーワード) Neuroblastoma / Abdominal compartment syndrome / Transpulmonary pressure (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050575882547923200 (CiNii: 1050575882547923200)
3.	Taiga Itagaki, Yusuke Akimoto, Yuki Nakano, Yoshitoyo Ueno, Manabu Ishihara, Natsuki Tane, Yumiko Tsunano and Jun Oto : Relationships between double cycling and inspiratory effort with diaphragm thickness during the early phase of mechanical ventilation: A prospective observational study., PLoS ONE, Vol.17, No.8, 2022. (要約) Double cycling on the third day of mechanical ventilation was associated with strong inspiratory efforts and, possibly, changes in diaphragm thickness. (キーワード) 成人 (adult) / Aged / Diaphragm / Humans / Positive-Pressure Respiration / Respiration, Artificial / Retrospective Studies / Ventilators, Mechanical (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0273173 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35976965 ● Search Scopus @ Elsevier (PMID): 35976965 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0273173 (DOI: 10.1371/journal.pone.0273173, PubMed: 35976965)
4.	Yoshitoyo Ueno, Saki Harada, Koji Sato, Kazuki Momota, Hiroki Sato, Yusuke Akimoto, Yuta Arai, Toshiyuki Nunomura, Manabu Ishihara, Natsuki Tane, Taiga Itagaki, Yasuhiko Nishioka and Jun Oto : Independent lung ventilation for the management of acute allograft rejection after single-lung transplantation for end-stage emphysema., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 323-327, 2022. (要約) Background : We herein report the use of independent lung ventilation (ILV) for managing acute allograft rejection after single-lung transplantation (SLT) for end-stage emphysema. Case presentation : A 54-year-old woman was transferred to our hospital with severe hypoxemia and respiratory distress due to unilateral lung disease with diffuse alveolar damage in the right donor lung associated with acute allograft rejection and with hyperinflation of the left native lung due to emphysema. She was unresponsive to immunosuppressive medications and conventional ventilation strategies, so different ventilator settings for each lung were required. A double-lumen endotracheal tube (DLT) was inserted, and ILV was initiated. The right lung was ventilated with high positive end-expiratory pressure (PEEP), intended for lung recruitment, and the left lung was ventilated with lung protective strategies using a low tidal volume and low levels of PEEP to avoid hyperinflation. Two days later, her lung function was dramatically improved, and the DLT was replaced with a single-lumen endotracheal tube. Gas exchange was maintained, and she was successfully weaned from mechanical ventilation on intensive-care unit day 15. Conclusions : ILV appears to be effective and safe for managing acute allograft rejection after SLT for emphysema. J. Med. Invest. 69 : 323-327, August, 2022. (キーワード) Allografts / Emphysema / Female / Humans / Lung / Lung Transplantation / Middle Aged / Pulmonary Emphysema / Respiration, Artificial (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.323 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244790 ● Search Scopus @ Elsevier (PMID): 36244790 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.323 (DOI: 10.2152/jmi.69.323, PubMed: 36244790)
5.	Yusuke Akimoto, Natsuki Bando, Hiroki Sato, Koji Sato, Kazuki Momota, Toshiyuki Nunomura, Yoshitoyo Ueno, Manabu Ishihara, Natsuki Tane, Taiga Itagaki and Jun Oto : Acquired laryngomalacia as a cause of post-extubation respiratory failure in patient with postoperative seizure and central pontine myelinolysis after craniotomy., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 316-319, 2022. (要約) Background : Laryngomalacia is a congenital abnormality of the larynx that commonly occurs in children and rarely in adults. We report the first case of acquired laryngomalacia mainly due to postoperative seizure and central pontine myelinolysis after scheduled craniotomy. Case presentation : A 69-year-old man was admitted to the hospital for elective craniotomy for craniopharyngioma. After the surgery, he developed refractory seizure and required intubation and mechanical ventilation in the intensive-care unit (ICU). After treatment for the seizure, he was extubated. However, immediately after extubation, he developed stridor and respiratory retraction. We performed fiberoptic laryngoscopy and confirmed that the epiglottis had collapsed into the posterior wall of the pharynx during inspiration, which was suspected to be laryngomalacia. He received invasive mechanical ventilation for two days following re-extubation. After the second extubation, he developed stridor again due to acquired laryngomalacia. Six days later, his respiratory condition had worsened, and he received re-intubation and tracheostomy. After ICU discharge, central pontine myelinolysis was diagnosed by magnetic resonance imaging. Conclusions : Adult-onset laryngomalacia is a rare cause of upper airway obstruction but should be considered as a cause of postoperative extubation failure. We should not delay performing fiberoptic laryngoscopy to evaluate this pathology and provide optimal treatment. J. Med. Invest. 69 : 316-319, August, 2022. (キーワード) Aged / Airway Extubation / Child / Craniotomy / Humans / Laryngomalacia / Laryngoscopy / Male / Myelinolysis, Central Pontine / Respiratory Insufficiency / Respiratory Sounds / Seizures (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.316 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244788 ● Search Scopus @ Elsevier (PMID): 36244788 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.316 (DOI: 10.2152/jmi.69.316, PubMed: 36244788)
6.	Yoshitoyo Ueno, Koji Sato, Kazuki Momota, Hiroki Sato, Yuki Nakano, Yusuke Akimoto, Toshiyuki Nunomura, Natsuki Tane, Taiga Itagaki and Jun Oto : The quality and quantity of sleep on dexmedetomidine during high-flow nasal cannula oxygen therapy in critically ill patients., The Journal of Medical Investigation : JMI, Vol.69, No.3.4, 266-272, 2022. (要約) Purpose : High-flow nasal cannula oxygen therapy (HFNC) is a new type of non-invasive respiratory support for acute respiratory failure patients. However, patients receiving HFNC often develop sleep disturbances. We therefore examined whether dexmedetomidine could preserve the sleep characteristics in patients who underwent HFNC. Patients and Methods : This was a pilot, randomized controlled study. We assigned critically ill patients treated with HFNC to receive dexmedetomidine (0.2 to 0.7 µg / kg / h, DEX group) or not (non-DEX group) at night (9:00 p.m. to 6:00 a.m.). Polysomnograms were monitored during the study period. The primary outcomes were total sleep time (TST), sleep efficiency and duration of stage 2 non-rapid eye movement (stage N2) sleep. Results : Of the 28 patients who underwent randomization, 24 were included in the final analysis (12 patients per group). Dexmedetomidine increased the TST (369 min vs. 119 min, p = 0.024) and sleep efficiency (68% vs. 22%, P = 0.024). The duration of stage N2 was increased in the DEX group compared with the non-DEX group, but this finding did not reach statistical significance. The incidences of respiratory depression and hemodynamic instability were similar between the two groups. Conclusions : In critically ill patients who underwent HFNC, dexmedetomidine may optimize the sleep quantity without any adverse events. J. Med. Invest. 69 : 266-272, August, 2022. (キーワード) Cannula / Critical Illness / Dexmedetomidine / Humans / Oxygen / Sleep (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.69.266 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244779 ● Search Scopus @ Elsevier (PMID): 36244779 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.69.266 (DOI: 10.2152/jmi.69.266, PubMed: 36244779)
7.	上野義豊, 大藤純 : 人工呼吸器のウィーニングと抜管, 救急·集中治療, Vol.33, No.4, 1232-1242, 2021年. (キーワード) 上野//義豊 / ウエノ//ヨシトヨ (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522543656133233152 (CiNii: 1522543656133233152)
8.	髙島拓也, 西川真理恵, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : ARDS に対する長期人工呼吸管理中に不動に伴う高 Calcium 血症を呈した 1例, 四国医学雑誌, Vol.76, No.5-6, 307-310, 2020年. (要約) Immobilization hypercalcemia is a rare complication in critically ill patients and causes weakness and gastrointestinal symptoms, symptoms that may lead to delayed rehabilitation and mobilization. A45-year-old woman developed ARDS and received prolonged mechanical ventilation. She received deep sedation to control excessive inspiratory effort and agitation until the 10th day. She developed hypercalcemia, which induced nausea and vomiting, on the fifth day. It was difficult to implement early physical rehabilitation and mobilization due to hypercalcemic symptoms. She was diagnosed with immobilization hypercalcemia and received alendronate sodium and elcatonin. The serum corrected calcium rapidly normalized and nausea disappeared after these drugs administration. After that, she underwent rehabilitation and was liberated from mechanical ventilation on the 63rd day. For the diagnosis of immobilization hypercalcemia, it is important to recognize risk factors such as long-term immobility, obesity, and an internal history of antiestrogens preparation. We should consider pharmacological intervention if it is difficult to implement early rehabilitation and mobilization due to symptoms of hypercalcemia. (キーワード) Immobilization / Hypercalcemia / Intensive care (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050005987795835136 (CiNii: 1050005987795835136)
9.	Nobuto Nakanishi, Jun Oto, Rie Tsutsumi, Tomoko Yamamoto, Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki, Hiroshi Sakaue and Masaji Nishimura : Effect of Electrical Muscle Stimulation on Upper and Lower Limb Muscles in Critically Ill Patients: A Two-Center Randomized Controlled Trial., Critical Care Medicine, Vol.48, No.11, e997-e1003, 2020. (要約) In critically ill patients, electrical muscle stimulation prevented upper and lower limb muscle atrophy and attenuated proteolysis and decreased the length of hospitalization. (キーワード) Aged / Amino Acids / Critical Illness / Electric Stimulation Therapy / Extremities / Female / Humans / Male / Muscle, Skeletal / Muscular Atrophy / Quadriceps Muscle / Single-Blind Method (徳島大学機関リポジトリ) ● Metadata: 115045 (出版サイトへのリンク) ● Publication site (DOI): 10.1097/CCM.0000000000004522 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32897665 ● Search Scopus @ Elsevier (PMID): 32897665 ● Search Scopus @ Elsevier (DOI): 10.1097/CCM.0000000000004522 (徳島大学機関リポジトリ: 115045, DOI: 10.1097/CCM.0000000000004522, PubMed: 32897665)
10.	Nobuto Nakanishi, Yasuhiro Suzuki, Manabu Ishihara, Yoshitoyo Ueno, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Effect of High-Flow Nasal Cannula on Sleep-disordered Breathing and Sleep Quality in Patients With Acute Stroke., Curēus, Vol.12, No.7, 2020. (要約) Introduction Sleep-disordered breathing (SDB) is common after stroke. Although the standard treatment of SDB is continuous positive airway pressure (CPAP) ventilation, the patient's intolerance and discomfort result in low adherence rates. Alternatively, high-flow nasal cannula (HFNC) may be useful as it reduces upper airway collapse with low level of positive pressure and well tolerability. The aim of this study was to investigate whether HFNC therapy reduces SDB and improves sleep quality with higher compliance rate. Methods We included acute stroke patients with SDB for the assessment of apnea-hypopnea index (AHI) >5/h using WatchPAT 200 (Itamar Medical Ltd, Caesarea, Israel). Patients who met inclusion criteria received HFNC therapy (40 L/min) with monitoring by WatchPAT. AHI, oxygen desaturation index (ODI), sleep efficiency, and rapid eye movement (REM) sleep were compared in patients with and without HFNC therapy. We also evaluated the patient's comfort of HFNC therapy (discomfort or not). Results Among 17 patients assessed for AHI, 12 received HFNC therapy. HFNC therapy was not adhered in two patients due to intolerance. Eight patients remained for final analysis. There were no differences in SDB and sleep quality with and without HFNC therapy as follows: HFNC therapy vs control; AHI 24.9 ± 20.1 vs 21.3 ± 15.0/h (p = 0.63), ODI 16.2 ± 16.5 vs 12.9 ± 12.3/h (p = 0.54), sleep efficiency 80.4 ± 12.9 vs 87.1 ± 6.2 (p = 0.28), percentage of REM sleep 19.4% ± 9.6% vs 27.6% ± 8.9% (p = 0.07). Two patients (17%) complained of discomfort among eight patients. Conclusion HFNC therapy did not improve SDB and sleep quality. Nonadherence and discomfort were observed in HFNC therapy. We need a large trial to confirm this result. (出版サイトへのリンク) ● Publication site (DOI): 10.7759/cureus.9303 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32832300 ● Search Scopus @ Elsevier (PMID): 32832300 ● Search Scopus @ Elsevier (DOI): 10.7759/cureus.9303 (DOI: 10.7759/cureus.9303, PubMed: 32832300)
11.	秋本雄祐, 上野義豊, 髙島拓也, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 側弯矯正固定術後の急性換気不全に対し気管支鏡による選択的気管支拡張術が奏功した1例, 日本集中治療医学会第4回中国・四国支部学術集会, 2020年.
12.	髙島拓也, 板垣大雅, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 大藤純 : 急性呼吸不全を合併した免疫不全患者に対する呼吸療法がICU転帰に与える影響∼NPPVとHFNCの比較∼, 四国医学雑誌, Vol.76, No.1-2, 55-60, 2020年. (要約) Background : Non-invasive positive pressure ventilation (NPPV) is highly recommended for immunocompromised patients with acute respiratory failure. In this population it remains uncertain, however, whether high flow nasal canula(HFNC)is as beneficial as NPPV. Methods : We retrospectively studied immunocompromised patients with acute respiratory failure admitted to our ICU from 2011 to 2018. The background and clinical outcomes of patients initially treated with HFNC and NPPV were compared. Results : Upon admission, 12 patients were treated with HFNC and 10 with NPPV. While the length of ICU stay was significantly shorter in HFNC group (HFNC4．6days vs. NPPV13．8days, p=0．02), no intergroup difference was seen in ICU mortality (16．7% vs.30．0%, p=0．46)or intubation rate(33．3% vs.50．0%, p=0．43). Conclusions : For immunocompromised patients with acute respiratory failure, HFNC may be an alternative to NPPV. Further prospective investigation is warranted. (キーワード) Acute respiratory failure / Immunocompromised patients / Noninvasive positive pressure ventilation / High flow nasal cannula (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050285299784995584 (CiNii: 1050285299784995584)
13.	秋本雄祐, 上野義豊, 髙島拓也, 中西信人, 田根なつ紀, 綱野祐美子, 石原学, 板垣大雅, 大藤純 : 当院ICUにおけるカルバペネム系抗菌薬の使用状況とde-escalationに関する検討．, 第47回日本集中治療医学会学術集会, 2020年.
14.	髙島拓也, 上野義豊, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 目標換気量の表示が人工呼吸患者の低一回換気量/肺保護換気の順守率に与える影響．, 第47回日本集中治療医学会学術集会, 2020年.
15.	板垣大雅, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 大藤純 : 人工呼吸開始後早期の患者-人工呼吸器非同調が横隔膜厚の変化に与える影響．, 第47回日本集中治療医学会学術集会, 2020年.
16.	Nobuto Nakanishi, Jun Oto, Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki and Masaji Nishimura : Change in diaphragm and intercostal muscle thickness in mechanically ventilated patients: A prospective observational ultrasougraphy study, Journal of Intensive Care, Vol.7, 56, 2020. (徳島大学機関リポジトリ) ● Metadata: 114542 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40560-019-0410-4 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1186/s40560-019-0410-4 (徳島大学機関リポジトリ: 114542, DOI: 10.1186/s40560-019-0410-4)
17.	Nobuto Nakanishi, Rie Tsutsumi, Yoshihiro Okayama, Takuya Takashima, Yoshitoyo Ueno, Taiga Itagaki, Yasuo Tsutsumi, Hiroshi Sakaue and Jun Oto : Monitoring of muscle mass in criticaly ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices, Journal of Intensive Care, Vol.7, 61, 2020. (要約) Skeletal muscle atrophy commonly occurs in critically ill patients, and decreased muscle mass is associated with worse clinical outcomes. Muscle mass can be assessed using various tools, including ultrasound and bioelectrical impedance analysis (BIA). However, the effectiveness of muscle mass monitoring is unclear in critically ill patients. This study was conducted to compare ultrasound and BIA for the monitoring of muscle mass in critically ill patients. We recruited adult patients who were expected to undergo mechanical ventilation for > 48 h and to remain in the intensive care unit (ICU) for > 5 days. On days 1, 3, 5, 7, and 10, muscle mass was evaluated using an ultrasound and two BIA devices (Bioscan: Malton International, England; Physion: Nippon Shooter, Japan). The influence of fluid balance was also evaluated between each measurement day. We analyzed 93 images in 21 patients. The age of the patients was 69 (interquartile range, IQR, 59-74) years, with 16 men and 5 women. The length of ICU stay was 11 days (IQR, 9-25 days). The muscle mass, monitored by ultrasound, decreased progressively by 9.2% (95% confidence interval (CI), 5.9-12.5%), 12.7% (95% CI, 9.3-16.1%), 18.2% (95% CI, 14.7-21.6%), and 21.8% (95% CI, 17.9-25.7%) on days 3, 5, 7, and 10 ( < 0.01), respectively, with no influence of fluid balance ( = 0.04, = 0.74). The muscle mass did not decrease significantly in both the BIA devices (Bioscan, = 0.14; Physion, = 0.60), and an influence of fluid balance was observed (Bioscan, = 0.37, < 0.01; Physion, = 0.51, < 0.01). The muscle mass assessment at one point between ultrasound and BIA was moderately correlated (Bioscan, = 0.51, < 0.01; Physion, = 0.37, < 0.01), but the change of muscle mass in the same patient did not correlate between these two devices (Bioscan, = - 0.05, = 0.69; Physion, = 0.23, = 0.07). Ultrasound is suitable for sequential monitoring of muscle atrophy in critically ill patients. Monitoring by BIA should be carefully interpreted owing to the influence of fluid change. UMIN000031316. Retrospectively registered on 15 February 2018. (キーワード) 超音波 (ultrasound) / Bioelectrical impedance analysis / 筋萎縮 (muscle atrophy) (徳島大学機関リポジトリ) ● Metadata: 114541 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40560-019-0416-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31890223 ● Summary page in Scopus @ Elsevier: 2-s2.0-85077117012 (徳島大学機関リポジトリ: 114541, DOI: 10.1186/s40560-019-0416-y, PubMed: 31890223, Elsevier: Scopus)
18.	Taiga Itagaki, Nobuto Nakanishi, Takuya Takashima, Yoshitoyo Ueno, Natsuki Tane, Yumiko Tsunano, Toshiyuki Nunomura and Jun Oto : Effect of controlled ventilation during assist-control ventilation on diaphragm thickness : a post hoc analysis of an observational study., The Journal of Medical Investigation : JMI, Vol.67, No.3.4, 332-337, 2020. (要約) Background : Since diaphragm passivity induces oxidative stress that leads to rapid atrophy of diaphragm, we investigated the effect of controlled ventilation on diaphragm thickness during assist-control ventilation (ACV). Methods : Previously, we measured end-expiratory diaphragm thickness (Tdiee) of patients mechanically ventilated for more than 48 hours on days 1, 3, 5 and 7 after the start of ventilation. We retrospectively investigated the proportion of controlled ventilation during the initial 48-hour ACV (CV48%). Patients were classified according to CV48% : Low group, less than 25% ; High group, higher than 25%. Results : Of 56 patients under pressure-control ACV, Tdiee increased more than 10% in 6 patients (11%), unchanged in 8 patients (14%) and decreased more than 10% in 42 patients (75%). During the first week of ventilation, Tdiee decreased in both groups : Low (difference, -7.4% ; 95% confidence interval [CI], -10.1% to -4.6% ; p < 0.001) and High group (difference, -5.2% ; 95% CI, -8.5% to -2.0% ; p = 0.049). Maximum Tdiee variation from baseline did not differ between Low (-15.8% ; interquartile range [IQR], -22.3 to -1.5) and High group (-16.7% ; IQR, -22.6 to -11.1, p = 0.676). Conclusions : During ACV, maximum variation in Tdiee was not associated with proportion of controlled ventilation higher than 25%. J. Med. Invest. 67 : 332-337, August, 2020. (徳島大学機関リポジトリ) ● Metadata: 115438 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.332 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148911 ● Summary page in Scopus @ Elsevier: 2-s2.0-85095587008 (徳島大学機関リポジトリ: 115438, DOI: 10.2152/jmi.67.332, PubMed: 33148911, Elsevier: Scopus)
19.	髙島拓也, 上野義豊, 石原学, 田根なつ紀, 中西信人, 綱野祐美子, 板垣大雅, 大藤純 : 高度肥満患者でのElectrical Impedance Tomographyと経肺圧を用いた適正PEEPの検討．, 第47回日本救急医学会総会, 2019年.
20.	田根なつ紀, 石原学, 髙島拓也, 上野義豊, 中西信人, 綱野祐美子, 板垣大雅, 大藤純 : 当院脳卒中センターにおける急性脳主幹動脈閉塞症例での病院前皮質症状評価の検討．, 第47回日本救急医学会総会, 2019年.
21.	綱野祐美子, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 板垣大雅, 大藤純 : ステロイドパルス療法により未診断の重症筋無力症の初期増悪から呼吸不全をきたした一症例, 日本救急医学会雑誌, 2019年.
22.	Takuya Takashima, Nobuto Nakanishi, Yoshitoyo Ueno, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Changes of diaphragm function before and after withdrawal of high flow nasal cannula in patients with acute respiratory failure., The 32nd Annual Congress of European Society of Intensive Care Medicine, Berlin, Germany, 2019.
23.	Taiga Itagaki, Nobuto Nakanishi, Yoshitoyo Ueno and Jun Oto : Effect of controlled ventilation on diaphragm atrophy during assist-control ventilation: a post hoc analysis., 6th SG-ANZICS Intensive Care Forum, Singapore, 2019.
24.	Yoshitoyo Ueno, Takuya Takashima, Nobuto Nakanishi, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Timing of tracheostomy in acute stroke patients., 6th SG-ANZICS Intensive Care Forum, Singapore, 2019.
25.	Taiga Itagaki, Yoshitoyo Ueno, Nobuto Nakanishi and Jun Oto : Reverse triggering induced by endotracheal tube leak in lightly sedated ARDS patient., Journal of Intensive Care, Vol.6, 2018. (要約) Reverse triggering is respiratory entrainment triggered by the ventilator especially seen among heavily sedated patients. We confirmed reverse triggering induced by auto-triggering in lightly sedated patient through an esophageal pressure monitoring. The reverse triggering frequently caused breath stacking with increased tidal volume. Physicians should be aware, even at an optimal level of sedation, that reverse triggering can develop, possibly caused by auto-triggering. (徳島大学機関リポジトリ) ● Metadata: 115520 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s40560-018-0314-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30065843 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050655300 (徳島大学機関リポジトリ: 115520, DOI: 10.1186/s40560-018-0314-8, PubMed: 30065843, Elsevier: Scopus)

学術論文(紀要・その他):

1.	上野義豊, 大藤純 : 人工呼吸に付随する諸問題:鎮痛鎮静薬, --- 呼吸管理2020-21 ガイドライン，スタンダード，論点そして私見 ---, 救急·集中治療, Vol.2020, No.32(1,2), 271-278, 2020年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669554881304064 (CiNii: 1523669554881304064)

国際会議:

1.	Yoshitoyo Ueno and Jun Oto : Effects of nocturnal dexmedetomidine on sleep quality in critically ill patients equipped with high flow nasal cannula., The 30th Annual Congress of European Society of Intensive Care Medicine, Paris, France (October 20), Oct. 2018.
2.	Yoshitoyo Ueno, Emiko Nakataki, Taiga Itagaki, Jun Oto and Masaji Nishimura : Relationship between neurologic values and extubation failure in stroke patients., The 37th KSCCM Annual Congress and Asian Critical Care Conference 2018, Seoul, Korea (April 27-28), Apr. 2018.
3.	Yoshitoyo Ueno, Takuya Takashima, Nobuto Nakanishi, Natsuki Tane, Yumiko Tsunano, Taiga Itagaki and Jun Oto : Timing of tracheostomy in acute stroke patients., 6th SG-ANZICS Intensive Care Forum, Singapore(April 20-22), Singapore, Apr. 2018.
4.	Taiga Itagaki, Nobuto Nakanishi, Yoshitoyo Ueno and Jun Oto : Effect of controlled ventilation on diaphragm atrophy during assist-control ventilation: a post hoc analysis., 6th SG-ANZICS Intensive Care Forum, Singapore(April 20-22), Apr. 2018.

国内講演発表:

1.	百田和貴, 板東夏生, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 非侵襲的陽圧換気中に縦隔気腫を来したCOVID-19肺炎の一症例．, 第50回日本集中治療医学会学術集会, 2023年3月.
2.	秋本雄祐, 板東夏生, 佐藤功志, 佐藤裕紀, 百田和貴, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 予定開頭手術後の橋中心髄鞘崩壊症が原因と考えられた成人喉頭軟化症の一症例．, 第50回日本集中治療医学会学術集会, 2023年3月.
3.	板東夏生, 上野義豊, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 電気インピーダンス・トモグラフィにて閉塞性無気肺を疑い，早期介入に至った重症COVID-19症例．, 第50回日本集中治療医学会学術集会, 2023年3月.
4.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 気管切開後25年間無症候性に経過した声門下狭窄が気管挿管を機に増悪し，術後抜管困難となった一症例, 第50回日本集中治療医学会学術集会, 2023年3月.
5.	上野義豊, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 末期肺気腫に対する片肺移植後の急性拒絶反応に対し，分離肺換気が奏功した一症例, 第50回日本集中治療医学会学術集会, 2023年3月.
6.	上野義豊, 佐藤裕紀, 百田和貴, 佐藤功志, 秋本雄祐, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : 開心術後患者における乳酸値ピークアウトまでの時間と術後経過との関連, 第50回日本集中治療医学会学術集会, 2023年3月.
7.	佐藤功志, 上野義豊, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 石原学, 田根なつ紀, 板垣大雅, 大藤純 : VA-ECMO, 第50回日本集中治療医学会学術集会, 2023年3月.
8.	上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : パネルディスカッション9:シームレスICU∼診療の一貫性や質の担保をどうするか(1)「当院集中治療室で実践する週交代の診療責任者の配置:治療の一貫性・質の向上を目指した取り組み」, 第50回日本集中治療医学会学術集会, 2023年3月.
9.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 布村俊幸, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 高位気管切開既往患者に生じた声門下狭窄および気管軟化症により術後抜管困難となった一症例, 第6回徳島外科学会, 2023年2月.
10.	板東夏生, 宮本憲哉, 百田和貴, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : セツキシマブ投与後のインフュージョンリアクションから心停止に至るも後遺症なく救命できた一症例, 第6回徳島外科学会, 2023年2月.
11.	上野義豊 : Lecture「末期肺気腫に対する片肺移植後，遠隔期の急性拒絶反応に対し，分離肺換気が奏功した一症例」, 第6回ER ICU ASSISTセミナー, 2023年2月.
12.	秋本雄祐, 板東夏生, 佐藤功志, 佐藤裕紀, 百田和貴, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : くも膜下出血後のたこつぼ心筋症および神経原性肺水腫に対してバゾプレシンを用いて循環管理を行った1例．, 第50回日本救急医学会総会・学術集会, 2022年10月.
13.	百田和貴, 板東夏生, 佐藤功志, 佐藤裕紀, 秋本雄祐, 布村俊幸, 石原学, 上野義豊, 田根なつ紀, 板垣大雅, 大藤純 : 重篤な循環不全を呈した重症レジオネラ肺炎に対しVA-ECMO導入により救命した1例．, 第50回日本救急医学会総会・学術集会, 2022年10月.
14.	石原学, 黒田一駿, 山本雄貴, 上野義豊, 田根なつ紀, 綱野祐美子, 板垣大雅, 高木康志, 大藤純 : 重症COVID-19感染後に発症した，脳葉型出血の1例．, 第49回日本集中治療医学会学術集会, 2022年3月.
15.	上野義豊, 秋本雄祐, 中野勇希, 石原学, 佐藤功志, 佐藤裕紀, 百田和貴, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 重症COVID-19患者の転院および救急搬送における問題点の検討．, 第49回日本救急医学会総会・学術集会, 2021年11月.
16.	中野勇希, 佐藤功志, 佐藤裕紀, 百田和貴, 秋本雄祐, 上野義豊, 石原学, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 腹部コンパートメント症候群による呼吸不全をきたした小児神経芽腫Stage 4Sの一症例．, 第49回日本救急医学会総会・学術集会, 2021年11月.
17.	上野義豊, 秋本雄祐, 中野勇希, 石原学, 荒瀬美晴, 百田和貴, 佐藤功志, 佐藤裕紀, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 重症COVID-19患者の転院および救急搬送における問題点の検討．, 第1回南四国・集中治療医学フォーラム, 2021年11月.
18.	板垣大雅, 秋本雄祐, 中野勇希, 上野義豊, 石原学, 田根なつ紀, 綱野祐美子, 大藤純 : 人工呼吸開始後早期のdouble cyclingが横隔膜厚の変化に与える影響．, 第43回日本呼吸療法医学会学術集会, 2021年7月.
19.	中西信人, 堤理恵, 上野義豊, 田根なつ紀, 綱野祐美子, 板垣大雅 : 「筋萎縮ゼロプロジェクト:PICS予防のための取り組み」, 日本集中治療医学会雑誌, 2021年2月.
20.	髙島拓也, 上野義豊, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 目標換気量の表示が人工呼吸患者の低一回換気量/肺保護換気の順守率に与える影響, 日本集中治療医学会雑誌, 2021年2月.
21.	秋本雄祐, 中西信人, 中野勇気, 髙島拓也, 上野義豊, 田根なつ紀, 綱野祐美子, 石原学, 板垣大雅, 大藤純 : 本邦ICUにおける心臓血管外科術後患者の疫学調査 -JIPADデータ解析-(優秀演題), 日本集中治療医学会雑誌, 2021年2月.
22.	秋本雄祐, 上野義豊, 髙島拓也, 石原学, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : 側弯矯正固定術後の急性換気不全に対し気管支鏡による選択的気管支拡張術が奏功した1例, 日本集中治療医学会第4回中国・四国支部学術集会, 2020年7月.
23.	石原学, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 綱野祐美子, 板垣大雅, 大藤純 : NIHSS5点以下の軽症脳主幹動脈閉塞症例の予後因子, 第47回日本救急医学会総会, 2019年10月.
24.	綱野祐美子, 髙島拓也, 上野義豊, 中西信人, 田根なつ紀, 板垣大雅, 大藤純 : ステロイドパルス療法により未診断の重症筋無力症の初期増悪から呼吸不全をきたした一症例, 第47回日本救急医学会総会, 2019年10月.
25.	上野義豊, 大藤純 : High Flow Nasal Cannula 装着中の患者におけるデクスメデトミジンの効果．, 日本集中治療医学会雑誌, 2019年3月.
26.	板垣大雅, 上野義豊, 中西信人, 奥田菜緒, 中瀧恵実子, 大藤純 : チューブリークに起因したリバーストリガを認めたARDS症例．, 日本集中治療医学会雑誌, 2019年3月.
27.	板垣大雅, 上野義豊, 中西信人, 奥田菜緒, 中瀧恵実子, 大藤純 : チューブリークに起因したリバーストリガを認めたARDS症例, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O7-2], 2019年2月.
28.	大藤純, 上野義豊, 中西信人, 髙島拓也, 板垣大雅 : 重症患者における血漿中オレキシン濃度と急性脳機能障害との関連, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O16-4], 2019年2月.
29.	西川真理恵, 髙島拓也, 鈴木康大, 上野義豊, 中西信人, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : ウイルス性気管支肺炎によりair leak syndromeを呈し2度のVenovenous ECMOを要した小児の一例, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O53-4], 2019年2月.
30.	髙島拓也, 板垣大雅, 鈴木康大, 上野義豊, 中西信人, 西川真理恵, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 大藤純 : 免疫不全患者の急性呼吸不全における呼吸療法 HFNCとNPPVの比較, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O83-2], 2019年2月.
31.	髙島拓也, 中西信人, 鈴木康大, 上野義豊, 西川真理恵, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : High Flow Nasal Cannulaの横隔膜機能に対する効果, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O83-3], 2019年2月.
32.	白神壮洋, 中西信人, 野寺裕之, 上野義豊, 板垣大雅, 中瀧恵実子, 大藤純 : ICU患者における上下肢筋萎縮の定性的評価超音波画像のテクスチャ解析, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [O129-2], 2019年2月.
33.	田根なつ紀, 髙島拓也, 鈴木康大, 上野義豊, 中西信人, 西川真理恵, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : 小児人工呼吸患者の鎮痛・鎮静レベルの評価 COMFORT-Bスケールの使用経験, 日本集中治療医学会雑誌, Vol.26, No.Suppl., [P53-4], 2019年2月.
34.	田根なつ紀, 髙島拓也, 鈴木康大, 上野義豊, 中西信人, 西川真理恵, 綱野祐美子, 奥田菜緒, 中瀧恵実子, 板垣大雅, 大藤純 : 気管チューブの固定により屈曲し内腔の狭窄を起こした一症例, 日本救急医学会雑誌, Vol.29, No.10, 572, 2018年10月.
35.	板垣大雅, 上野義豊, 中西信人, 西川真理恵, 田根なつ紀, 奥田菜緒, 中瀧恵実子, 大藤純 : RAM cannulaTMを用いた新生児非侵襲的人工換気の経験, , 2018年8月.
36.	上野義豊, 板垣大雅, 大藤純, 西村匡司 : ヨード含有の軟膏使用によりアナフィラキシーショックに至った一例, 第34回日本救急医学会中国四国地方会学術集会(5月11∼12日,広島市), 2018年5月.
37.	上野義豊, 大藤純 : High Flow Nasal Cannula 装着中の患者におけるデクスメデトミジンの効果, 日本集中治療医学会雑誌, 2018年3月.
38.	上野義豊, 大藤純, 西村匡司 : High flow nasal cannula装着中の患者における睡眠動態の検討．, 第45回日本集中治療医学会学術集会, 2018年2月.
39.	上野義豊, 小野寺睦雄, 大藤純, 西村匡司 : 気管挿管中の脳血管障害患者における神経学的重症度および人工呼吸期間と抜管の成否との関係．, 日本集中治療医学会第2回中国・四国支部学術集会, 2018年1月.

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助教 : 上野義豊

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専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

国際会議:

国内講演発表:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 上野 義豊

研究活動

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

学術論文(紀要・その他):

国際会議:

国内講演発表:

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

助教 : 上野義豊