Tokushima University / Educator and Researcher Directory --- Kagawa, Tomohiro

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Tokushima University ⟩ University Hospital ⟩ Central Clinical Facilities ⟩ Department of Community and Obstetrics and Gynecology ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Pediatrics,Obstetrics and Gynecology ⟩ Obstetrics snd Gynecology ⟩
Tokushima University ⟩ Faculty of Medicine ⟩ School of Medicine ⟩ Course of Human Development ⟩ Obstetrics and Gynecology ⟩

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Research

Field of Study

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Book / Paper

Academic Paper (Judged Full Paper):

1.	Akiko Abe, Masao Yuasa, Yoshie Imai, Tomohiro Kagawa, Ayuka Mineda, Masato Nishimura, Chisato Tonoiso, Akiko Kubo, Takashi Kawanaka, Hitoshi Ikushima and Takeshi Iwasa : Extreme leanness, lower skeletal muscle quality, and loss of muscle mass during treatment are predictors of poor prognosis in cervical cancer treated with concurrent chemoradiation therapy, International Journal of Clinical Oncology, Vol.27, No.5, 983-991, 2022. (Summary) Human papillomavirus vaccination is not widespread in Japan, and the low screening rates result in many cases of locally advanced cervical cancer. We investigated the prognostic significance of sarcopenia in patients with cervical cancer to guide healthcare policies to improve treatment outcomes. This retrospective study included 83 patients with cervical cancer without distant metastasis who underwent primary concurrent chemoradiotherapy between 2013 and 2018. We analyzed the indicators of physical condition and muscle quantity using the SYNAPSE VINCENT software. Muscle mass and the relationship between treatment toxicity and prognosis were evaluated. The patients' median age was 60 (range 33-80) years. Cancer stage distribution was as follows: cT2b or higher, 84.3%; N1, 65.1%; and MA, 27.7%. The overall sarcopenia (skeletal muscle index [SMI] < 38.5) rate was 30.1%, and the rate was 33.9 and 22.2% in patients aged < 64 and ≥ 65 years, respectively. No correlation was observed between clinical stage and musculoskeletal indices. Treatment resulted in decreased body weight and SMI; after treatment, the sarcopenia rate increased to 37.3%. A higher intramuscular adipose tissue content (IMAC) reduced the number of chemotherapy cycles needed. Treatment-associated SMI decreases of ≥ 7% indicated poor prognosis, with significant differences in progression-free survival and overall survival (p = 0.013 and p = 0.012, respectively). Patients who were very lean (body mass index < 18.5 kg/m) before treatment had a poor prognosis (p = 0.016 and p < 0.001). Our findings emphasize the importance of assessing original nutritional status and maintaining muscle mass and quality during the treatment of patients with cervical cancer. (Keyword) Adult / Aged / Aged, 80 and over / Chemoradiotherapy / Female / Humans / Middle Aged / Muscle, Skeletal / Papillomavirus Infections / Papillomavirus Vaccines / Prognosis / Retrospective Studies / Sarcopenia / Thinness / Uterine Cervical Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1007/s10147-022-02140-w (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35212828 ● Summary page in Scopus @ Elsevier: 2-s2.0-85125283470 (DOI: 10.1007/s10147-022-02140-w, PubMed: 35212828, Elsevier: Scopus)
2.	Shuhei Kamada, Yuri Yamamoto, Hidenori Aoki, Kou Tamura, Asuka Takeda, Saki Minato, Rie Masaki, Rie Yanagihara, Noriko Hayashi, Yuya Yano, Junki Imaizumi, Tomohiro Kagawa, Atsuko Yoshida, Takako Kawakita, Minoru Irahara and Takeshi Iwasa : A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes., Reproductive Medicine and Biology, Vol.21, No.1, e12416, 2021. (Summary) Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models. We tried to produce an improved rat model of PCOS, and the reproductive, metabolic, and behavioral phenotypes of the model rats were evaluated. Female rats were implanted with silicon tubes containing oil-dissolved dihydrotestosterone (Oil-DHT) as a new PCOS model. Their phenotypes were compared with those of conventional PCOS model rats (DHT), into which tubes containing crystalline DHT were implanted, and non-DHT-treated rats (control). Both the Oil-DHT and DHT rats showed greater body weight gain, food intake, and fat depot weight than the control rats. Furthermore, these groups showed fewer estrous stages and increased numbers of cystic follicles. The DHT rats exhibited lower ovarian and uterine weights than the control rats, whereas no such changes were observed in the Oil-DHT rats. The Oil-DHT and DHT rats showed less locomotor activity in the light phase than the control rats. Our proposed PCOS model reproduced both the reproductive and metabolic phenotypes of PCOS and may have potential for PCOS research. (Tokushima University Institutional Repository) ● Metadata: 117712 (Link to Publication Site) ● Publication site (DOI): 10.1002/rmb2.12416 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34934399 ● Search Scopus @ Elsevier (PMID): 34934399 ● Search Scopus @ Elsevier (DOI): 10.1002/rmb2.12416 (Tokushima University Institutional Repository: 117712, DOI: 10.1002/rmb2.12416, PubMed: 34934399)
3.	Ayuka Mineda, Masato Nishimura, Tomohiro Kagawa, Eri Takiguchi, Takako Kawakita, Akiko Abe and Minoru Irahara : Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway., Experimental and Therapeutic Medicine, Vol.17, No.3, 2242-2246, 2019. (Summary) Resveratrol, a natural product and peroxisome proliferator-activated receptor (PPAR) agonist, has been reported to exert anti-cancer effects in several tumor models. A previous study by our group reported that prostaglandin J2, a PPARγ ligand, inhibited cell proliferation in a uterine sarcoma cell line. The aim of the present study was to investigate the role of the Wnt signaling pathway in resveratrol-induced apoptosis and inhibition of cell proliferation in the MES-SA human uterine sarcoma cell line. A WST-1 assay demonstrated that resveratrol inhibited cell proliferation in the MES-SA cell line, and flow cytometry revealed that the number of apoptotic cells increased in a resveratrol dose-dependent manner. The mechanisms underlying these effects of resveratrol were speculated to involve the expression of β-catenin and its target gene, c-myc, which were examined using western blot analysis. The results revealed a dose-dependent downregulation of this β-catenin and c-myc. This effect was blunted by a pharmacological inhibitor of glycogen synthase kinase 3β. Therefore, it is likely that resveratrol inhibited the cell proliferation and increased the number of apoptotic cells, at least partially, via the Wnt signaling pathway. The present results suggest that resveratrol is a potential candidate for the treatment of uterine sarcoma. (Tokushima University Institutional Repository) ● Metadata: 113338 (Link to Publication Site) ● Publication site (DOI): 10.3892/etm.2019.7209 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30867708 ● Search Scopus @ Elsevier (PMID): 30867708 ● Search Scopus @ Elsevier (DOI): 10.3892/etm.2019.7209 (Tokushima University Institutional Repository: 113338, DOI: 10.3892/etm.2019.7209, PubMed: 30867708)

Academic Paper (Unrefereed Paper):

1.	篠原文香, Ayuka Mineda, 乾宏彰, Tomohiro Kagawa, 阿部彰子, 西條康代, Masato Nishimura, Minoru Irahara and Takeshi Iwasa : 術前に卵巣原発胚細胞性腫瘍を疑ったが, 傍卵巣の平滑筋肉腫であった一例, Modern Trends in Obstetrics & Gynecology, Vol.70, No.1, 227-231, 2021. (Keyword) 骨盤内腫瘍 / 平滑筋肉腫 / 画像評価 / 栄養血管 / pelvic tumor / leiomyosarcoma / image evaluation / feeding blood vessels / コツバンナイシュヨウ / ヘイカツキンニクシュ / ガゾウヒョウカ / エイヨウケッカン (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520290885604307712 (CiNii: 1520290885604307712)
2.	Akiko Abe, Tomohiro Kagawa, 祖川英至, Ayuka Mineda and Masato Nishimura : Mismatch repair deficiency in young patients of reproductive age with endometrial cancer and atypical endometrial hyperplasia, Journal of Hereditary Tumors, Vol.20, No.3, 146-150, 2020. (Summary) <p>MPA therapy is widely administered to patients with early-stage endometrial cancer and atypical endometrial hyperplasia (AEH) who desire a fertility-preserving treatment modality. We examined the relationship between MMR protein expression and the effects of MPA therapy, risk of relapse, prognosis, and familial history in 21 patients. We observed MMR deficiency in 7 patients (MLH1: 4, PMS2: 5, MSH2: 2, and MSH6: 2). All patients with lymph node metastasis or who died had MLH1 deficiency. In 13 of 21 patients, we performed MPA therapy for fertility preservation and confirmed MMR deficiency in 2. After the initial treatment, ovarian cancer developed in 2 patients, one of whom had Peutz-Jeghers syndrome. Due to the small sample size of this study, we found no significant association between MMR deficiency and the effects of MPA therapy or the risk of relapse. Many young patients with endometrial tumors may have inherited diseases, although not necessarily with MMR deficiency. Therefore, clinical assessment considering their past history and family history should be performed prior to each treatment. Our findings will serve as a catalyst for future studies with larger sample sizes.</p> (Keyword) endometrial cancer / mismatch repair deficiency / hereditary tumor (Link to Publication Site) ● Publication site (DOI): 10.18976/jsht.20.3_146 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390286981364673792 ● Search Scopus @ Elsevier (DOI): 10.18976/jsht.20.3_146 (DOI: 10.18976/jsht.20.3_146, CiNii: 1390286981364673792)
3.	Tomohiro Kagawa, Akiko Abe, Hiroaki Inui, Ayuka Mineda and Masato Nishimura : 嚢胞状帝王切開瘢痕部が着床部結節から成っていた一例, Modern Trends in Obstetrics & Gynecology, Vol.69, No.1, 5-9, 2020. (Keyword) cesarean scar syndrome / intermediate trophoblast / placental site nodule (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572359820341376 (CiNii: 1520572359820341376)

Review, Commentary:

1.	Aya Shirakawa, Kanako Yoshida, 村山美咲, Junki Imaizumi, Tomohiro Kagawa, Takako Kawakita, Takeshi Katou and Takeshi Iwasa : 腹腔鏡下手術を契機に発見した腹膜黒色色素沈着の一例, Japanese Journal of Gynecologic and Obstetric Endoscopy, Vol.38, No.2, 157-161, Aug. 2022. (Tokushima University Institutional Repository) ● Metadata: 118525 (Tokushima University Institutional Repository: 118525)

Proceeding of International Conference:

1.	Akiko Abe, Akira Kuwahara, Tomohiro Kagawa, Ayuka Mineda and Masato Nishimura : A survey of germline mutations with epithelial ovarian cancer in Japanese patients., ESGO Annual Meeting 2019, Greece, Nov. 2019.

Proceeding of Domestic Conference:

1.	Asami Yuasa, Susumu Nishio, Sae Morita, MATSUMOTO Rikizo, Yukina Hirata, Tomohiro Kagawa, Hirohisa Ogawa, Yoshimi Bando and Masataka Sata : 深部静脈血栓症を契機に発見された子宮内膜症性嚢胞を伴う卵巣甲状腺腫の1例, 第33回日本超音波産学会四国地方会学術集会, Oct. 2023.
2.	Asami Yuasa, Susumu Nishio, Sae Morita, MATSUMOTO Rikizo, Yukina Hirata, Tomohiro Kagawa, Hirohisa Ogawa, Yoshimi Bando and Masataka Sata : 深部静脈血栓症を契機に発見された子宮内膜症性嚢胞を伴う卵巣甲状腺腫の1例, 第33回日本超音波産学会四国地方会学術集会, Oct. 2023.
3.	Kanako Yoshida, Takeshi Katou, 武田明日香, Ryosuke Arakaki, 今泉絢貴, Tomohiro Kagawa, Ayuka Mineda, 河北貴子, Yuri Yamamoto, 苛原稔 and Takeshi Iwasa : ワークショップ:効率よくTLH上達を目指すための当科での取り組み, 第62回日本産婦人科内視鏡学会, Sep. 2022.
4.	前田崇彰, Masato Nishimura, 祖川英至, Atsuko Yoshida, 米谷直人, Takako Kawakita, Tomohiro Kagawa, Akiko Abe, Takashi Kaji and Minoru Irahara : 胎盤病理検査を契機に診断・治療に至った子宮体癌の1例, 第72回日本産科婦人科学会学術集会, Apr. 2020.
5.	Takeshi Iwasa, Toshiya Matsuzaki, Akiko Abe, 柳原理江, Yuri Yamamoto, Tomohiro Kagawa, Ayuka Mineda, Masato Nishimura, Akira Kuwahara and Minoru Irahara : 子宮内膜異型増殖症・初期子宮体癌患者に対する黄体ホルモン療法の治療成績，妊娠成績および周産期予後, 第72回中国四国日本産科婦人科学会学術講演会, Sep. 2019.
6.	Tomohiro Kagawa, Akiko Abe, Ayuka Mineda and Masato Nishimura : 嚢胞状帝王切開瘢痕部が着床部結節からなっていた一例, 第72回中国四国日本産科婦人科学会学術講演会, Sep. 2019.
7.	Akiko Abe, Issei Imoto, Tomohiro Kagawa, Ayuka Mineda, Masato Nishimura and Minoru Irahara : 上皮性卵巣癌に対する遺伝学的検査への意識調査とHRD遺伝子変異の検討, 第61回日本婦人科腫瘍学会, Jul. 2019.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

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