Tokushima University / Educator and Researcher Directory --- Kagusa, Hiroshi

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Tokushima University ⟩ University Hospital ⟩ Central Clinical Facilities ⟩ Tokushima Community Medical Support Center ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Neurosurgery, Psychiatry and Anesthesiology ⟩ Neurosurgery ⟩

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Research

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Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Yoshitaka Kurashiki, Hiroshi Kagusa, Kenji Yagi, Tomoya Kinouchi, Manabu Sumiyoshi, Takeshi Miyamoto, Kenji Shimada, Keiko T Kitazato, Yoshihiro Uto and Yasushi Takagi : Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage, Journal of Cerebral Blood Flow and Metabolism, 2022. (Summary) Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment of various cell types to the ischemic area. Although anti-inflammatory M2-type macrophages are thought to exert protective effects against cerebral ischemia, little has been clarified regarding the significance of post-ischemic phase-dependent modulation of M2-type macrophages. To test our hypothesis that post-ischemic phase-dependent modulation of macrophages represents a potential therapy against ischemic brain damage, the effects on rats of an M2-type macrophage-specific activator, Gc-protein macrophage-activating factor (GcMAF), were compared with vehicle-treated control rats in the acute (day 0-6) or subacute (day 7-13) phase after ischemia induction. Acute-phase GcMAF treatment augmented both anti-inflammatory CD163 M2-type- and pro-inflammatory CD16 M1-type macrophages, resulting in no beneficial effects. Conversely, subacute-phase GcMAF injection increased only CD163 M2-type macrophages accompanied by elevated mRNA levels of arginase-1 and interleukin-4. M2-type macrophages co-localized with CD36 phagocytic cells led to clearance of the infarct area, which were abrogated by clodronate-liposomes. Expression of survival-related molecules on day 28 at the infarct border was augmented by GcMAF. These data provide new and important insights into the significance of M2-type macrophage-specific activation as post-ischemic phase-dependent therapy. (Link to Publication Site) ● Publication site (DOI): 10.1177/0271678X221147090 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36545833 ● Summary page in Scopus @ Elsevier: 2-s2.0-85145451559 (DOI: 10.1177/0271678X221147090, PubMed: 36545833, Elsevier: Scopus)
2.	Izumi Yamaguchi, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Yoshiteru Tada, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Hiroshi Kagusa, Yoko Yamamoto, Taku Matsuda, Keiko T. Kitazato, Yoshihiro Okayama and Yasushi Takagi : Chronic subdural hematoma associated with dural metastasis leads to early recurrence and death: A single-institute, retrospective cohort study, Journal of Clinical Neuroscience, Vol.94, 244-249, 2021. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jocn.2021.10.037 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2021.10.037 (DOI: 10.1016/j.jocn.2021.10.037)
3.	Yoshifumi Mizobuchi, Aki Shimada, Kohhei Nakajima, Hiroshi Kagusa and Yasushi Takagi : Reversible Hearing Impairment Due to Inferior Colliculi Compression by a Pineal Glial Cyst, NMC Case Report Journal, Vol.8, No.1, 79-84, 2021. (Link to Publication Site) ● Publication site (DOI): 10.2176/nmccrj.cr.2020-0123 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34012754 ● CiNii @ National Institute of Informatics (CRID): 1390850247501001984 ● Search Scopus @ Elsevier (PMID): 34012754 ● Search Scopus @ Elsevier (DOI): 10.2176/nmccrj.cr.2020-0123 (DOI: 10.2176/nmccrj.cr.2020-0123, PubMed: 34012754, CiNii: 1390850247501001984)
4.	Kenji Shono, Izumi Yamaguchi, Yoshifumi Mizobuchi, Hiroshi Kagusa, Akiko Sumi, Toshitaka Fujihara, Kohhei Nakajima, T Keiko Kitazato, Kazuhito Matsuzaki, Hideyuki Saya and Yasushi Takagi : Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma., Scientific Reports, Vol.10, No.1, 2020. (Summary) microglia. In GSCs, celecoxib inhibited Ccl2 and Cxcr3 expression in a nuclear factor-kappa B-dependent manner but not Ccr2 and CxcL10. Moreover, Ccl2 silencing resulted in decreased GSC viability. These results suggest that celecoxib-mediated regulation of the CCL2/CCR2 and CXCL10/ CXCR3 axes may partially contribute to glioma-specific antitumor effects. (Keyword) Animals / Antineoplastic Agents / Cell Line / Chemokine CCL2 / Chemokine CXCL10 / Disease Models, Animal / Down-Regulation / Glioma / Humans / Male / Mice / Mice, Inbred C57BL / Microglia / Receptors, CCR2 / Receptors, CXCR3 / Stem Cells / Tumor Microenvironment (Tokushima University Institutional Repository) ● Metadata: 117722 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-020-71857-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32943658 ● Search Scopus @ Elsevier (PMID): 32943658 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-71857-3 (Tokushima University Institutional Repository: 117722, DOI: 10.1038/s41598-020-71857-3, PubMed: 32943658)
5.	Hiroshi Kagusa, Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Yoshimi Bando and Yasushi Takagi : Metastatic tumor to the orbital cavity from a primary carcinoma of the uterine cervix : a case report., The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 355-357, 2019. (Summary) Metastatic tumors to the orbit of the eye, especially from primary carcinomas of the uterine cervix are very rare. A 64-year-old woman with a history of carcinoma of the uterine cervix presented with right eye pain and blepharoptosis for 2 weeks. Magnetic resonance imaging revealed a mass at the right orbital apex. Surgical extirpation was performed due to severe pain. Postoperative pathology demonstrated a poorly differentiated squamous cell carcinoma. The origin was ultimately considered to be the carcinoma of the uterine cervix. In conclusion, this report describes a rare case of a metastatic tumor at the orbital apex derived from the cervix of the uterus. J. Med. Invest. 66 : 355-357, August, 2019. (Tokushima University Institutional Repository) ● Metadata: 114169 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.66.355 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656305 ● Search Scopus @ Elsevier (PMID): 31656305 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.355 (Tokushima University Institutional Repository: 114169, DOI: 10.2152/jmi.66.355, PubMed: 31656305)

Proceeding of Domestic Conference:

1.	Izumi Yamaguchi, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Yoshiteru Tada, Takeshi Miyamoto, Shu Sogabe, Manabu Ishihara, Hiroshi Kagusa, 山本陽子, Taku Matsuda, 北里慶子 and Yasushi Takagi : 硬膜転移が慢性硬膜下血腫の転帰に及ぼす影響についての後視的検討, 第46回日本脳神経外傷学会, Feb. 2023.
2.	西尾進, Kenya Kusunose, 高橋寛典, Hiroshi Kagusa, 平田有紀奈, 森田沙瑛, 山口夏美, 鳥居裕太, 山尾雅美, Zheng Robert, 西條良仁, 山田なお, 林修司, 阿部美保, 武市脩, Hirotsugu Yamada and Masataka Sata : 急性脳梗塞患者の病型分類におけるB型ナトリウム利尿ペプチドと心エコー図指標の臨床的意義, 日本心エコー図学会第30回学術集会, May 2019.
3.	Yuki Yamamoto, Kazutaka Kuroda, Nobuaki Yamamoto, Hiroshi Kagusa, Masaaki Korai, Kenji Shimada, Yasuhisa Kanematsu, Yuishin Izumi and Yasushi Takagi : 頭癌治療中に内頚動脈閉塞を認めた1例, 第21回徳島脳血管障害カンファレンス, Mar. 2019.
4.	Susumu Nishio, Kenya Kusunose, Hiroshi Kagusa, Yukina Hirata, Yuta Torii, 天野里江, 山尾雅美, Yoshihito Saijoh, Mika Bando, Hirotsugu Yamada and Masataka Sata : 急性期脳卒中患者におけるB型ナトリウム利尿ペプチドの臨床的意義, 第66回日本心臓病学会学術集会, Sep. 2018.

Et cetera, Workshop:

1.	Taku Matsuda, Hiroshi Kagusa, 梅村公子, Nori Sato, Ryoma Morigaki, Hideo Mure, Yasuhisa Kanematsu, Yuki Matsumoto, Masafumi Harada, Shinsuke Katoh and Yasushi Takagi : ロボットスーツHALを用いた脳卒中急性期リハビリテーションの当院での取り組み, 第8回日本脳神経HAL研究会, Feb. 2020.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

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