徳島大学 / 教育研究者総覧 --- 山下理子

個人のホームページ

https://www.tokushima-u.ac.jp/med/health_science/course/keitai_kensa/pathological-analysis/

専門分野

○	臨床病理学 (Clinical Pathology)
○	医療教育 (Medical Education)

研究テーマ

○	骨髄病理学と臨床検査医学の相関 (骨髄膠様変性, CAR細胞, 臨床検査値)
○	病理解剖症例を用いた医学教育, CPC, Reversed CPC (ワークショップ (workshop), 臨床病理検討会(CPC), RCPC, 病理解剖)

著書・論文

著書:

1.	佐藤康晴, 竹内賢吾, 山下理子 : III. 自己免疫疾患関連 2 全身性エリテマトーデス関連リンパ節症. 非腫瘍性疾患病理アトラスリンパ組織, 文光堂, 東京, 2023年4月.

学術論文(審査論文):

1.	Batkhishig Munkhjargal, Kazuya Kondo, Shiho Soejima, Bilguun Tegshee, Michiko Yamashita, Naoya Kawakita, Hiroaki Toba and Hiromitsu Takizawa : DNA methylation and mRNA expression of ZNF577 as biomarkers for the detection and prognosis of lung adenocarcinoma., Oncology Reports, Vol.52, No.4, 2024. (要約) Despite advances in science and technology, lung cancer remains a major public health issue. The discovery of early diagnostic and prognostic markers is still needed to reduce the mortality rate of lung cancer, which is the highest among all cancer types. Aberrations in the DNA methylation system have an important role in human cancer and are promising for the development of early diagnostic and prognostic markers. The present study focused on zinc finger protein (ZNF)577, whose encoding gene was indicated to exhibit promoter hypermethylation together with 9 other genes in lung adenocarcinoma (LADC) in a previous study by our group. ZN577 is a member of the ZNG family and its functional role has so far remained elusive. LADC tissue samples surgically resected at Tokushima University Hospital (Tokushima, Japan) between April 1999 and November 2013 were collected. A total of 73 tumors and 27 paired tumor-adjacent normal tissues were examined for DNA methylation and mRNA expression of ZNF577. A total of 149 LADC tissue samples were collected and evaluated by immunohistochemistry (IHC) for the tissue expression of ZNF577. High methylation (n=27, P<0.0001) and low mRNA expression levels (n=27, P<0.031) of ZNF577 were identified in LADC tissues, and it was demonstrated that methylation levels were inversely correlated with mRNA expression levels (P=0.0116, ϱ=-0.2515). Among the LADC tissues, lepidic-patterned samples had lower methylation levels of ZNF577 than other pathological types. In addition, mRNA expression levels of ZNF577 were significantly higher in females, non-smokers and stage I samples. Overall survival [P<0.0001; area under curve (AUC)=0.8658] and disease-free survival (DFS; P<0.0004; AUC=0.7232) rates were significantly higher in the ZNF577 high mRNA expression group than in the ZNF577 low mRNA expression group. Among the 149 LADC samples examined by IHC, 105 were negative and 44 were positive for the tissue expression of ZNF577. Cox regression analysis showed poorer DFS (hazard ratio: 3.917; P=0.023) in patients with lower expression of ZNF577. In conclusion, higher methylation levels of ZNF577 were observed in LADC tissues than in normal lung tissue and low mRNA expression of ZNF577 was associated with unfavorable prognosis. (キーワード) Humans / DNA Methylation / 女性 (female) / 男性 (male) / Biomarkers, Tumor / Lung Neoplasms / Prognosis / Adenocarcinoma of Lung / Adenocarcinoma / Aged / Middle Aged / RNA, Messenger / Gene Expression Regulation, Neoplastic / Promoter Regions, Genetic / Adult / Aged, 80 and over (出版サイトへのリンク) ● Publication site (DOI): 10.3892/or.2024.8790 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39129302 ● Summary page in Scopus @ Elsevier: 2-s2.0-85201248740 (DOI: 10.3892/or.2024.8790, PubMed: 39129302, Elsevier: Scopus)
2.	厚美憲吾, 松本穣, 山下理子, 西村碧フィリーズ, 佐藤康晴, 坂東良美, 上原久典 : 免疫染色にてCD8陽性,CD25陰性を示した成人T細胞白血病リンパ腫の1例, 診断病理, Vol.41, No.4, 2024年. (キーワード) lymph node / adult T-cell leukemia/lymphoma (ATLL / 免疫組織化学 (immunohistochemistry) / CD8 / CD25
3.	Tamaki Ohtani, Hitoshi Ikushima, Yoshimi Bando, Michiko Yamashita, Kenmei Kuwahara, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi : Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT, The Journal of Medical Investigation : JMI, Vol.70, No.3,4, 361-368, 2023. (要約) This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023. (キーワード) Humans / Mice / Animals / Carcinoma, Non-Small-Cell Lung / Fluorodeoxyglucose F18 / Positron Emission Tomography Computed Tomography / Lung Neoplasms / Radiopharmaceuticals / Positron-Emission Tomography (徳島大学機関リポジトリ) ● Metadata: 118771 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.361 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940520 ● Search Scopus @ Elsevier (PMID): 37940520 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.361 (徳島大学機関リポジトリ: 118771, DOI: 10.2152/jmi.70.361, PubMed: 37940520)
4.	影治里穂, 飛田泰斗史, 原朋子, 山下理子, 坂本佳奈, 竹内賢吾 : 芽球性形質細胞様樹状細胞腫瘍の皮膚病変に対して放射線療法が有効であった一例, 日本臨床皮膚科医会雑誌, Vol.39, No.4, 562-566, 2022年. (キーワード) 芽球性形質細胞様樹状細胞腫瘍 / BPDCN / 放射線治療 (radiation therapy) (出版サイトへのリンク) ● Publication site (DOI): 10.3812/jocd.39.562 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390293500928209280 ● Search Scopus @ Elsevier (DOI): 10.3812/jocd.39.562 (DOI: 10.3812/jocd.39.562, CiNii: 1390293500928209280)
5.	Mayuko Shimizu, Yosuke Tsuchiyama, Yuki Morimoto, Minoru Matsumoto, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Takeshi Oya, Hirohisa Ogawa, Michiko Yamashita, Satoru Matsuda, Katsuhisa Omagari, Shu Taira and Koichi Tsuneyama : A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages, The American Journal of Pathology, Vol.192, No.1, 31-42, 2022. (要約) Various cells, such as macrophages and hepatic stellate cells, interact in the generation of fibrosis in nonalcoholic steatohepatitis (NASH), but the mechanism remains unclear. We employed a high-fat/cholesterol/cholate (HFCC) diet to generate a model of NASH-related fibrosis and investigate the pathogenesis of fibrosis. Two mouse strains differing in susceptibility to obesity, the susceptible strain C57BL/6J and the relatively resistant strain A/J, developed hepatic histologic features of NASH, including fat deposition, intralobular inflammation, hepatocyte ballooning, and fibrosis, after 9 weeks of HFCC diet feeding. The severity of hepatic inflammation and fibrosis was greater in A/J mice than in C57BL/6J mice. A/J mice fed the HFCC diet exhibited characteristic CD204-positive lipid-laden macrophage aggregation in hepatic parenchyma. Polarized light visualized the Maltese cross (namely, cholesterol crystals within the aggregated macrophages). Moreover, fibrosis developed in a ring shape from the periphery of the aggregated macrophages (ie, the starting point of fibrosis could be visualized histologically). Furthermore, matrix-assisted laser desorption/ionization mass spectrometry imaging analysis detected a molecule at m/z 772.462, which corresponds to the protonated ion of phosphatidylcholine [P-18:1 (11Z)/18:0] and phosphatidylethanolamine [18:0/20:2 (11Z, 14Z)], in aggregated macrophages adjacent to the fibrotic lesions. In conclusion, the present HFCC diet-fed A/J model provides an ideal tool to study fibrogenesis and enables novel insights into the pathophysiology of NASH-related fibrosis. (キーワード) Liver fibrosis / マクロファージ (macrophage) / animal model / コレステロール (cholesterol) / cholate (徳島大学機関リポジトリ) ● Metadata: 116411 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ajpath.2021.10.002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34710382 ● CiNii @ 国立情報学研究所 (CRID): 1360857593792147200 ● Search Scopus @ Elsevier (PMID): 34710382 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajpath.2021.10.002 (徳島大学機関リポジトリ: 116411, DOI: 10.1016/j.ajpath.2021.10.002, PubMed: 34710382, CiNii: 1360857593792147200)
6.	Tomoko Kobayashi, Mayuko Shimizu, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Yuki Morimoto, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Chunmei Cheng and Koichi Tsuneyama : Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet., Pathology, Research and Practice, Vol.225, No.153559, 2021. (要約) Although diabetes mellitus (DM) is a well-known risk factor for hepatocellular carcinoma (HCC), the underlying mechanisms have not yet to be defined. We previously reported that DIAR mice fed with standard murine diet developed type 1 diabetes and HCC at age of 16 weeks old with a neonatal streptozotocin treatment (n-STZ). Because DIAR mice did not manifest obesity nor develop steatohepatitis, hyperglycemia with streptozotocin trigger or streptozotocin alone might turn on the hepato-carcinogenesis. An insulin-recruitment to DIAR-nSTZ mice showed an increased frequency of HCC during the first 12 weeks of age, although the diabetic indications notably improved. To elucidate the role of hyperglycemia in hepato-carcinogenesis, we performed a head-to-head comparative study by using 4CS mice and DIAR mice with n-STZ treatment. Newborn 4CS mice and DIAR mice were divided into STZ treated group and control group. The blood glucose levels of DIAR-nSTZ mice increased at age of eight weeks, while that of 4CS-nSTZ mice were maintained in the normal range. At eight weeks old, three out of five DIAR-nSTZ mice (60%) and one out of ten 4CS-nSTZ mice (10%) developed multiple liver tumors. At age of 12 weeks old, all eight of DIAR-nSTZ mice (100%) and two of 10 4CS-nSTZ mice (20%) developed multiple liver tumors. At 16 weeks old, all animals of DIAR-nSTZ and 4CS-nSTZ mice occurred liver tumors. DIAR-nSTZ showed hyperglycemia and HCC, and 4CS-nSTZ developed HCC without hyperglycemia. These results were interpreted that the onset of HCC maybe not related to the presence or absence of hyperglycemia but nSTZ treatment. On the other hand, since the carcinogenesis of 4CS-nSTZ is delayed compared to DIAR-nSTZ, hyperglycemia may play a role in the progression of carcinogenesis. Histologically, the liver tumor appeared irregularly trabecular arrangements of hepatocytes with various degrees of nuclear atypia. By immunohistochemical analyses, all liver tumors showed positive staining of glutamine synthetase (GS), an established human HCC marker. The expression pattern of GS was divided into a strong diffuse pattern and weak patchy pattern, respectively. The liver tumor showing the weak GS-patchy pattern expressed biliary/stem markers, EpCAM, and SALL4, partially. Because 4CS-nSTZ mice did not show any metabolic complications such as gaining body weight or high blood glucose level, it is a unique animal model with a simple condition to investigate hepatic carcinogenesis by excluding other factors. (徳島大学機関リポジトリ) ● Metadata: 118286 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.prp.2021.153559 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34325313 ● Search Scopus @ Elsevier (PMID): 34325313 ● Search Scopus @ Elsevier (DOI): 10.1016/j.prp.2021.153559 (徳島大学機関リポジトリ: 118286, DOI: 10.1016/j.prp.2021.153559, PubMed: 34325313)
7.	Yuki Morimoto, Takeshi Oya, Mayuko Shimizu, Minoru Matsumoto, Hirohisa Ogawa, Tomoko Kobayashi, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Chunmei Cheng and Koichi Tsuneyama : Applying Probe Electrospray Ionization Mass Spectrometry to Cytological Diagnosis: A Preliminary Study by Using Cultured Lung Cancer Cells., Acta Cytologica, Vol.65, No.5, 430-439, 2021. (要約) PESI-MS presented a promising potential as a novel diagnostic modality for swiftly acquiring specific cytological information. (徳島大学機関リポジトリ) ● Metadata: 116345 (出版サイトへのリンク) ● Publication site (DOI): 10.1159/000516639 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34098551 ● Search Scopus @ Elsevier (PMID): 34098551 ● Search Scopus @ Elsevier (DOI): 10.1159/000516639 (徳島大学機関リポジトリ: 116345, DOI: 10.1159/000516639, PubMed: 34098551)
8.	Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Izawa-Ishizawa Yuki, Licht Miyamoto, Ishizawa Keisuke, Hiromichi Fujino, Toshiaki Tamaki, Ken-ichi Aihara and Koichiro Tsuchiya : Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity, Kidney International, Vol.99, No.4, 885-889, 2021. (要約) Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is currently available. Here, based on a repositioning analysis of the Food and Drug Administration Adverse Events Reporting System, we found that a previously developed drug, diphenhydramine, may provide a novel treatment for cisplatin-induced kidney toxicity. To confirm this, the actual efficacy of diphenhydramine was evaluated in in vitro and in vivo experiments. Diphenhydramine inhibited cisplatin-induced cell death in kidney proximal tubular cells. Mice administered cisplatin developed kidney injury with significant dysfunction (mean plasma creatinine: 0.43 vs 0.15 mg/dl) and showed augmented oxidative stress, increased apoptosis, elevated inflammatory cytokines, and MAPKs activation. However, most of these symptoms were suppressed by treatment with diphenhydramine. Furthermore, the concentration of cisplatin in the kidney was significantly attenuated in diphenhydramine-treated mice (mean platinum content: 70.0 vs 53.4 μg/g dry kidney weight). Importantly, diphenhydramine did not influence or interfere with the anti-tumor effect of cisplatin in any of the in vitro or in vivo experiments. In a selected cohort of 98 1:1 matched patients from a retrospective database of 1467 patients showed that patients with malignant cancer who had used diphenhydramine before cisplatin treatment exhibited significantly less acute kidney injury compared to ones who did not (6.1 % vs 22.4 %, respectively). Thus, diphenhydramine demonstrated efficacy as a novel preventive medicine against cisplatin-induced kidney toxicity. (徳島大学機関リポジトリ) ● Metadata: 115399 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.kint.2020.10.041 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33307103 ● Search Scopus @ Elsevier (PMID): 33307103 ● Search Scopus @ Elsevier (DOI): 10.1016/j.kint.2020.10.041 (徳島大学機関リポジトリ: 115399, DOI: 10.1016/j.kint.2020.10.041, PubMed: 33307103)
9.	Mayuko Shimizu, Katsuhisa Omagari, Michiko Yamashita and Koichi Tsuneyama : Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis., Bioscience, Biotechnology, and Biochemistry, Vol.85, No.4, 941-947, 2021. (要約) Nonalcoholic steatohepatitis (NASH) progresses to liver fibrosis and cirrhosis. Existing mouse models of NASH rarely develop diet-induced severe fibrosis. We aimed to establish a dietary model of NASH with rapid progression to fibrosis. Six-week-old male Tsumura-Suzuki obese diabetes (TSOD) mice (a model of spontaneous metabolic syndrome) and corresponding control Tsumura-Suzuki nonobese (TSNO) mice were fed a novel diet high in fat, cholesterol, and cholate (iHFC). Histologic steatohepatitis, including steatosis, inflammation, and fibrosis, were observed in both TSNO and TSOD iHFC diet-fed mice at 20 weeks of age. As compared with TSOD mice, TSNO mice developed much more severe fibrosis and reached stage 3 of bridging fibrosis within 14 weeks under the iHFC diet feeding. Perivenular/perisinusoidal pattern of fibrosis in TSNO mice resembled human NASH. Our model of NASH with advanced fibrosis by simple diet offers many advantages useful in studying the mechanism of liver fibrosis and preclinical drug testing. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/bbb/zbaa107 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33620426 ● Search Scopus @ Elsevier (PMID): 33620426 ● Search Scopus @ Elsevier (DOI): 10.1093/bbb/zbaa107 (DOI: 10.1093/bbb/zbaa107, PubMed: 33620426)
10.	山下理子, 中園雅彦, 春藤譲治, 黒田直人, 尾矢剛志 : 2002年以前に報告された日本人胃のHamartomatous inverted polyp (inverted hyperplastic polyp)の臨床病理学的所見の検討, 四国医学雑誌, Vol.76, No.1,2, 61-68, 2020年. (要約) Gastric hamartomatous inverted polyp (g-HIP) is rare gastric elevated lesion forming endophytic growth pattern which etiology remains unknown. G-HIP is said to be associated with gastric cancer and gastritis. We systematically reviewed Japanese g-HIP's clinicopathological features reported before2002. Japanese g-HIP amount to20lesions,18patients ; 7(38 9%)were males and 11(61 1%)were females. The mean age of patients was 60 2 years old. The mean size of the lesions was21 7millimeter. No of the polyp shape was Yamada type IV7, Yamada type I/flat elevation 6, Yamada type III 4 and Yamada II 3, respectively. The site of the lesions was Body11, Cardia3, Fornix3and Antrum1, respectively. In12described cases, accompanied lesion was Gastritis, Carcinoma, GCP, Hyperplastic polyp, GIST and remnant stomach due to ulcer. Of the submucosal shaped(Yamada type I/flat elevation)g-HIP,50% has GCP and62 5% has gastric cancer. The common feature of g-HIP was pyloric gland-like mucous gland proliferation and cystic dilatation in the H. pylori era of Japan. (キーワード) hamartomatous hyperplastic polyp / inverted hyperplastic polyp / stomach / gastritis cystica profunda / Helicobacter pylori (徳島大学機関リポジトリ) ● Metadata: 114857 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050865122805928320 (徳島大学機関リポジトリ: 114857, CiNii: 1050865122805928320)
11.	森理, 富林敦司, 江藤祥平, 松尾祐太, 常城宇生, 牧秀則, 山下理子 : 根治切除9年以上経過後に上縦隔リンパ節再発した食道癌の1例, 日本臨床外科学会雑誌, Vol.81, No.1, 54-59, 2020年. (出版サイトへのリンク) ● Publication site (DOI): 10.3919/jjsa.81.54 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390285300179534336 ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.81.54 (DOI: 10.3919/jjsa.81.54, CiNii: 1390285300179534336)
12.	山下理子, 後藤哲也, 勢井伸幸, 藤井義幸, 春川純一 : リンパ系腫瘍のGiemsa banding法が検査不能となる要因についての一施設検討, 臨床病理, Vol.67, No.10, 1011-1016, 2019年. (キーワード) lymphnodebiopsy(リンパ節生検) / Giemsabanding:G-band(G分染法) / lymphoma(リンパ腫) / extranodal(節外性) (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520853834480717696 (CiNii: 1520853834480717696)
13.	Yoshihiro Matsudate, Michiko Yamashita, Yoshiyuki Fujii and Yoshio Urano : Contact granulomatous hypersensitivity to indium in a patient with orofacial granulomatosis., Contact Dermatitis, Vol.81, No.4, 293-294, 2019. (キーワード) Dental Amalgam / Granulomatosis, Orofacial / Humans / Hypersensitivity, Delayed / Indium / Lip Diseases / Patch Tests (出版サイトへのリンク) ● Publication site (DOI): 10.1111/cod.13284 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30957231 ● Search Scopus @ Elsevier (PMID): 30957231 ● Search Scopus @ Elsevier (DOI): 10.1111/cod.13284 (DOI: 10.1111/cod.13284, PubMed: 30957231)
14.	大谷龍治, 山下理子, 陳博敏, 當別當洋平, 米田浩平, 泉智子, 宮島等, 安岡辰雄, 小倉理代, 弓場健一郎, 高橋健文, 細川忍, 岸宏一, 日浅芳一, 藤井義幸 : 頭痛と胸痛で発症し，下壁誘導に明瞭な J 波を伴った Brugada 症候群の 1 剖検例, 心電図, Vol.37, 23-30, 2017年. (キーワード) Brugada 症候群 / J 波 / 心静止 / 病理解剖 (徳島大学機関リポジトリ) ● Metadata: 119649 (徳島大学機関リポジトリ: 119649)
15.	後藤正和, 沖津宏, Yasuhiro Yuasa, Yuta Matsuo, Hiroshi Edagawa, Ryotaro Tani, Osamu Mori, Shunsuke Kuramoto, Atsushi Tomibayashi, 山下理子, Yoshiyuki Fujii : [A Case of Complete Pathological Response in a Patient with Locally Advanced Sigmoid Colon Cancer after FOLFOX IRI Chemotherapy]., 癌と化学療法, Vol.42, No.11, 1431-1434, 2015年. (要約) A 61-year-old man with advanced sigmoid colon cancer was admitted to our hospital. Abdominal computed tomography (CT) revealed locally advanced sigmoid colon cancer, with suspected invasion of the bladder and small intestine. The clinical stage of the disease was T4b, N1, M0, and Stage III a, with wild-type KRAS expression. A transverse colostomy was performed because of the presence of a bowel obstruction. The patient received 4 courses of Leucovorin, 5-fluorouracil, oxaliplatin, and irinotecan (FOLFOXIRI). The size of the tumor and lymph nodes decreased noticeably after chemotherapy and laparoscopic high anterior resection with lymph node dissection. During this phase, the pathological stage of the disease was ypT0, N0, and Stage 0(no viable carcinoma cells, Grade 3). This result suggested that preoperative FOLFOXIRI chemotherapy is a useful regimen for the treatment of locally advanced colon cancer. (キーワード) Antineoplastic Combined Chemotherapy Protocols / Biopsy / Combined Modality Therapy / Humans / Male / Middle Aged / Neoplasm Staging / Sigmoid Neoplasms / Tomography, X-Ray Computed (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26602406 ● Search Scopus @ Elsevier (PMID): 26602406 (PubMed: 26602406)
16.	Michiko Yamashita, Yoshiyuki Fujii, Keiji Ozaki, Yoshio Urano, Masami Iwasa, Shingen Nakamura, Shiroh Fujii, Masahiro Abe, Yasuharu Sato and Tadashi Yoshino : Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma., Diagnostic Pathology, Vol.10, 185, 2015. (要約) Malignant syphilis or lues maligna is a severe form of secondary syphilis that was commonly reported in the pre-antibiotic era, and has now reemerged with the advent of the human immunodeficiency virus (HIV) epidemic. However, the characteristic histopathological findings of malignant syphilis remain controversial. The aim of this case report was to clarify the clinical and histopathological findings of HIV-positive malignant secondary syphilis. A Japanese man in his forties complained of fever, skin lesions, headache, and myalgia without lymphadenopathy during the previous 4 weeks. The skin lesions manifested as erythematous, nonhealing, ulcerated papules scattered on his trunk, extremities, palm, and face. Although the skin lesions were suspected to be cutaneous T-cell lymphomas on histological analyses, they lacked T-cell receptor Jγ rearrangement; moreover, immunohistochemical analyses confirmed the presence of spirochetes. The patient was administered antibiotics and anti-retroviral therapy, which dramatically improved the symptoms. On the basis of these observations of the skin lesions, we finally diagnosed the patient with HIV-associated secondary syphilis that mimicked cutaneous T-cell lymphoma. The patient's systemic CD4+ lymphocyte count was very low, and the infiltrate was almost exclusively composed of CD8+ atypical lymphocytes; therefore, the condition was easily misdiagnosed as cutaneous lymphoma. Although the abundance of plasma cells is a good indicator of malignant syphilis on skin histological analyses, in some cases, the plasma cell count may be very low. Therefore, a diagnosis of malignant secondary syphilis should be considered before making a diagnosis of primary cutaneous peripheral T-cell lymphoma or lymphoma associated with HIV infection. (キーワード) AIDS-Related Opportunistic Infections / Anti-Bacterial Agents / Anti-HIV Agents / Biopsy / Coinfection / Diagnosis, Differential / HIV Infections / Humans / 免疫組織化学 (immunohistochemistry) / Lymphoma, T-Cell, Cutaneous / 男性 (male) / Predictive Value of Tests / 皮膚 (skin) / Skin Neoplasms / Syphilis / Syphilis, Cutaneous / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s13000-015-0419-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26449225 ● Summary page in Scopus @ Elsevier: 2-s2.0-84943540407 (DOI: 10.1186/s13000-015-0419-5, PubMed: 26449225, Elsevier: Scopus)
17.	谷口千尋, 松立吉弘, 櫻山ゆう子, 山下理子, 浦野芳夫 : 妊娠前期に発症したStevens-Johnson症候群の1例, 皮膚科の臨床, Vol.56, No.9, 1319-1323, 2014年. (キーワード) Stevens-Johnson症候群 / 妊婦 / アセトアミノフェン / 塩酸セフカペンピボキシル (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1521417754959986688 (CiNii: 1521417754959986688)
18.	中野誠一, 秋月裕則, 岩﨑英隆, 山下理子, 藤井義幸, 近藤英司, 雫治彦, 田村公一, 武田憲昭 : 感染を繰り返したlaryngocele例, 耳鼻咽喉科臨床, Vol.106, No.5, 439-445, 2013年. (要約) We report herein on a case of laryngocele with recurrent infection. A 48-year-old male complained of hoarseness and swelling of the left side of his neck. The endoscopic and CT scan examinations demonstrated the combined type of laryngocele that had expanded through the thyrohyoid membrane and had swollen up both medially and laterally in a dumbbell-like shape. To avoid the risk of laryngeal stenosis with the enlarged laryngocele infected by bacteria, in addition to intravenous infusion of an anti-bacterial drug, purulent discharge was drained from the infected laryngocele with a puncture needle. Because infection of the laryngocele was recurrent, it was surgically removed via an external neck approach under general anesthesia without any prophylactic tracheotomy. The laryngocele may be translated from a saccular cyst that had developed after the obstruction of communication between the laryngeal ventricle and the laryngeal saccule. (キーワード) laryngocele / saccular cyst / laryngeal ventricle / laryngeal saccule / laryngopyocele (出版サイトへのリンク) ● Publication site (DOI): 10.5631/jibirin.106.439 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204273025280 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878023452 (DOI: 10.5631/jibirin.106.439, CiNii: 1390001204273025280, Elsevier: Scopus)
19.	大住真敬, 松枝崇, 来島敦史, 大谷享史, 福村好晃, 藤井義幸, 山下理子, 宮恵子, 角谷佳昭 : 自己免疫性疾患が原因と考えられる若年巨大胸部大動脈瘤に対する手術経験, 心臓, Vol.43, No.12, 1577-1580, 2011年. (キーワード) SLE / 自己免疫性疾患 / 血管炎 / 胸部大動脈瘤 (出版サイトへのリンク) ● Publication site (DOI): 10.11281/shinzo.43.1577 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679026610176 ● Search Scopus @ Elsevier (DOI): 10.11281/shinzo.43.1577 (DOI: 10.11281/shinzo.43.1577, CiNii: 1390282679026610176)
20.	森川朋美, 岩佐美沙, 湊真子, 井形香織, 村澤恵美, 山下理子, 来島敦史, 福村好晃 : Staphylococcus lugdunensis による自己弁感染性心内膜炎の1症例, 医学検査, Vol.59, No.7, 847-851, 2010年. (キーワード) Staphylococcus lugdunensis / 感染性心内膜炎 / native valve endocarditis / CNS (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1572824501048452864 (CiNii: 1572824501048452864)
21.	Takeshi Iwasa, Anna Tani, Yuka Miyatani, Shirou Bekku, Michiko Yamashita, Kazuyo Nakanishi, Yoshiyuki Fujii and Hiroyasu Ino : Lymphangioma of the ovary accompanied by chylous ascites., The Journal of Obstetrics and Gynaecology Research, Vol.35, No.4, 812-815, 2009. (要約) Lymphangioma of the ovary is very rare, with only 17 cases reported to date. In this report, a 43-year-old woman with lymphangioma of the ovary accompanied by chylous ascites is described. Vaginal ultrasound showed a solid cystic tumor at the right ovary accompanied by ascites. The volume of ascites was changeable. Milky fluid obtained by Douglas pouch aspiration contained numerous mature lymphocytes. She underwent right salpingo-oophorectomy. Histological examination revealed that the excised tumor from the right ovary was consistent with benign lymphangioma. This is the first case report of lymphangioma of the ovary accompanied by chylous ascites. We should discriminate such cases from other malignant tumors in order to avoid overtreatment. (キーワード) Adult / Chylous Ascites / Female / Humans / Lymphangioma / Ovarian Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1447-0756.2009.01016.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19751350 ● CiNii @ 国立情報学研究所 (CRID): 1570854175897531520 ● Summary page in Scopus @ Elsevier: 2-s2.0-70049094210 (DOI: 10.1111/j.1447-0756.2009.01016.x, PubMed: 19751350, CiNii: 1570854175897531520, Elsevier: Scopus)
22.	Kazuhisa Katayama, 沖津宏, Suguru Kimura, Tomoko Hara, Keiji Ozaki, Tetsuya Goto, 山下理子, Yoshiyuki Fujii : S-1によりDIC から離脱し得た胃癌術後播種性骨髄癌症の1 例, 癌と化学療法, Vol.35, No.7, 1201-1204, 2008年. (要約) Bone marrow carcinosis due to gastric cancer with disseminated intravascular coagulation(DIC)occurs suddenly, progresses rapidly, and has a very poor prognosis. In addition, physical status tends to be bad at the time of the episode, and palliative care is generally selected as the treatment method. The case was a 70-year-old woman who underwent total gastrectomy for scirrhous stomach cancer five years previously. She recently noticed gingival hemorrhage, and was referred to our hospital by a nearby doctor. As a result of her examination, she was diagnosed with disseminated bone marrow carcinosis as a postoperative recurrence of gastric cancer that resulted in DIC. We transfused blood platelets and fresh frozen plasma into her, and controlled the bleeding tendency temporarily. She was started on oral administration of S-1 for improvement of DIC, and the therapy was successful without loss of QOL. It is easy to continue S-1 therapy as chemotherapy in the outpatient department, because it is a matter of internal medicine. (キーワード) Aged / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Biopsy / Bone Marrow Neoplasms / Disseminated Intravascular Coagulation / Drug Combinations / 女性 (female) / Gastrectomy / Humans / Oxonic Acid / Radionuclide Imaging / Stomach Neoplasms / Tegafur / Tomography, X-Ray Computed (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18633263 ● Search Scopus @ Elsevier (PMID): 18633263 (PubMed: 18633263)
23.	Michiko Yamashita, Toshiaki Sano, Zhi-Rong Qian, Kalman Kovacs and Eva Horvath : Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association., Endocrine Pathology, Vol.17, No.2, 155-164, 2006. (要約) Horvath et al. called relatively small ACTH-immunoreactive (ACTH-IR) cells observed in basophil invasion "proopiomelanocortin (POMC) cells," and these cells were supposed to be different from larger ACTH-IR cells in human adenohypophysis. To clarify the existence of "anterior POMC cells," we examined 21 autopsy cases taking note of follicular cells (FCs). We found that smaller ACTH-IR cells were clustered forming small areas without FC association, clustered small cell island (CSCI). CSCI was found in all the specimens we examined using immunohistochemical staining for ACTH and cytokeratin (AE1/AE3) in serial sections. ACTH-IR cells outside CSCI were of various sizes, mainly consisting of larger ACTH-IR cells that were diffusely scattered among other hormone-secreting cells and closely associated with FCs. By immunohistochemistry, ACTH-IR cells within CSCI and basophil invasion showed uniformly weak reactivity and common patterns for cytokeratins (CAM5.2 and 35 beta H11), carboxypeptidase D, and LeuM1, whereas those outside CSCI showed a great variety of immunoreactivity. The similarity in the immunoreactivity of ACTH-IR cells between CSCI and basophil invasion suggests that ACTH-IR cells in these two areas have common characteristics and ACTH-IR cells in CSCI are most likely "POMC cells." The clustered "anterior POMC cells" may be distinguishable by light microscopic immunohistochemistry. (キーワード) Adrenocorticotropic Hormone / Aged / Basophils / 女性 (female) / Humans / 免疫組織化学 (immunohistochemistry) / 男性 (male) / Middle Aged / Pituitary Gland, Anterior / Pro-Opiomelanocortin (出版サイトへのリンク) ● Publication site (DOI): 10.1385/EP:17:2:155 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17159248 ● Search Scopus @ Elsevier (PMID): 17159248 ● Search Scopus @ Elsevier (DOI): 10.1385/EP:17:2:155 (DOI: 10.1385/EP:17:2:155, PubMed: 17159248)
24.	Michiko Yamashita, Zhi-Rong Qian, Toshiaki Sano, Eva Horvath and Kalman Kovacs : immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis., Pathology International, Vol.55, No.5, 244-247, 2005. (要約) Non-hormone-secreting cells in human adenohypophysis have been designated as either follicular cells (FC) or folliculostellate cells (FSC). They have similarly long cytoplasmic processes, and the difference between FC and FSC remains unclear. An immunohistochemical study for S-100 protein, cytokeratin (CK, detected by AE1/AE3) and glial fibrillary acidic protein (GFAP) was performed in autopsy pituitaries. Double immunohistochemistry for S-100 protein and CK revealed that there were numerous coexpressed cells. The most frequent type ('CK-type cell') was cells weakly positive for S-100 protein in the nucleus and for CK-immunoreactivity in the cytoplasm. The next numerous type ('S-100 protein cell') was cells strongly positive for S-100 protein and weakly positive or negative for CK. The CK-type cells were frequently observed in the vicinity of follicular structures and in neighborhood of adrenocorticotropic hormone -immunoreactive cells, and were most likely the cells termed FC. They were often observed around necrotic areas. The S-100 protein cells were individually found in the circumference of endocrine cell nest, and seemed to be the so-called stellate cells. GFAP-positive cells were rare. It is implied that S-100 protein-positive FSC could be divided into at least two main subtypes: FC (CK-type cells) and stellate cells (S-100 protein cells). (キーワード) Adrenocorticotropic Hormone / Female / Glial Fibrillary Acidic Protein / Humans / Immunohistochemistry / Keratins / Male / Middle Aged / Pituitary Gland, Anterior / S100 Proteins (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1440-1827.2005.01820.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15871721 ● Search Scopus @ Elsevier (PMID): 15871721 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-1827.2005.01820.x (DOI: 10.1111/j.1440-1827.2005.01820.x, PubMed: 15871721)
25.	Ken-ichi Aihara, Hiroyuki Azuma, Masashi Akaike, Yasumasa Ikeda, Michiko Yamashita, Toshiki Sudo, Hideki Hayashi, Yoshihisa Yamada, Fuminari Endoh, Mitsunori Fujimura, Tomonori Yoshida, Hiroshi Yamaguchi, Shunji Hashizume, Midori Kato, Kimihiro Yoshimura, Yoko Yamamoto, Shigeaki Kato and Toshio Matsumoto : Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice, The Journal of Biological Chemistry, Vol.279, No.34, 35798-35802, 2004. (要約) Vitamin D metabolites influence the expression of various genes involved in calcium homeostasis, cell differentiation, and regulation of the immune system. Expression of these genes is mediated by the activation of the nuclear vitamin D receptor (VDR). Previous studies have shown that a hormonally active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, exerts anticoagulant effects in cultured monocytic cells. To clarify whether activation of VDR plays any antithrombotic actions in vivo, hemostatic/thrombogenic systems were examined in normocalcemic VDR knock-out (KO) mice on a high calcium diet and compared with wild type and hypocalcemic VDRKO mice that were fed a regular diet. Platelet aggregation was enhanced significantly in normocalcemic VDRKO mice compared with wild type and hypocalcemic VDRKO mice. Aortic endothelial nitric-oxide (NO) synthase expression and urinary NOx excretions were reduced in hypocalcemic VDRKO mice, but not in normocalcemic VDRKO mice. Northern blot and RT-PCR analyses revealed that the gene expression of antithrombin in the liver as well as that of thrombomodulin in the aorta, liver and kidney was down-regulated in hypo- and normocalcemic VDRKO mice. Whereas tissue factor mRNA expression in the liver and kidney was up-regulated in VDRKO mice regardless of plasma calcium level. Furthermore, VDRKO mice manifested an exacerbated multi-organ thrombus formation after exogenous lipopolysaccharide injection regardless of the calcemic conditions. These results demonstrate that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggest that the VDR system may play a physiological role in the maintenance of antithrombotic homeostasis. (キーワード) FILTRATION PRESSURE METHOD / TISSUE-FACTOR / 1,25-DIHYDROXYVITAMIN D-3 / ANTITHROMBIN DEFICIENCY / WHOLE-BLOOD / EXPRESSION / 細胞 (cells) / AGGREGATION / 阻害 (inhibition) / ALOPECIA (出版サイトへのリンク) ● Publication site (DOI): 10.1074/jbc.M404865200 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15205460 ● CiNii @ 国立情報学研究所 (CRID): 1362262945661168512 ● Summary page in Scopus @ Elsevier: 2-s2.0-4143096123 (DOI: 10.1074/jbc.M404865200, PubMed: 15205460, CiNii: 1362262945661168512, Elsevier: Scopus)
26.	Hideko Endo, Mitsuyoshi Hirokawa, Naozumi Ishimaru, Yasushi Tanaka, Michiko Yamashita, Mika Sakaki, Yoshio Hayashi and Toshiaki Sano : Unique cell membrane expression if topoisomerase-ll alpha as a useful diagnostic marker of liposarcoma, Pathology International, Vol.54, No.3, 145-150, 2004. (要約) Topoisomerase-II alpha (Topo-II alpha) is known as a cell cycle-related intranuclear marker. To the best of our knowledge, the expression of Topo-II alpha on extranuclear sites has not been reported. The aim of the present study was to determine the usefulness of Topo-II alpha immunostaining for detecting the lipoblasts that are essential to diagnosing liposarcoma. Surgical specimens, including benign lipomatous tumors (four cases), well-differentiated liposarcomas (three cases), myxoid liposarcomas (six cases), pleomorphic liposarcomas (two cases), dedifferentiated liposarcomas (two cases), myxoid malignant fibrous histiocytomas (six cases), and one case of mesenteric panniculitis, were studied. Samples were immunostained using antibodies for Topo-II alpha, S-100 protein and Ki-67. In addition, we used the western blot method to investigate immunohistochemical-affinity in adipocytes. Mature adipocytes and lipoblasts in all of the benign and malignant lipomatous tumors intensively expressed cell contours positivity for Topo-II alpha. Cytoplasm of the lipoblasts occasionally reacted to the antibody and highlighted intracytoplasmic small unilocular, multivacuolated, or bubble-like patterns. Western blot analysis confirmed a 70 kDa product reactive to Topo-II alpha in the cell membrane fragment of mature adipocytes. S-100 protein expressed adipocytes and lipoblasts, but the detection of lipoblasts was not as easy as in Topo-II alpha immunostaining. Immunoreactivity of Ki-67 was limited to the nuclei, and the nuclear labeling index of Ki-67 correlated with that of Topo-II alpha. The immunoreactivity of Topo-II alpha for lipoblasts was more sensitive and obvious than those of S-100 protein. Immunostaining using the antibody for Topo-II alpha seems to be useful in recognizing lipoblasts that have been overlooked in hematoxylin-eosin-stained preparations, and is a useful marker for diagnosing liposarcoma. (キーワード) adipocytes / lipoblasts / liposarcoma / malignant fibrous histiocytoma / S-100 protein / topoisomerase-ll alpha (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1440-1827.2003.01600.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14989736 ● Search Scopus @ Elsevier (PMID): 14989736 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1440-1827.2003.01600.x (DOI: 10.1111/j.1440-1827.2003.01600.x, PubMed: 14989736)
27.	Michiko Yamashita, Mitsuyoshi Hirokawa, Masahiko Nakasone, Hiroshi Kiyoku, Nobuya Sano, Masahiko Fujii, Takashi Koyama, Sadahiro Yoshida and Toshiaki Sano : Gastric inverted hyperplastic polyp. Report of four cases and relation to gastritis cystica profunda, APMIS, Vol.110, No.10, 717-723, 2002. (要約) Gastric inverted hyperplastic polyp (IHP) is a rare type of gastric polyp, and is characterized by downward growth of the hyperplastic mucosal components into the submucosa. To the best ofour knowledge, 16 gastric IHP cases have been described in the English literature, but the pathogenesis has not been established. We report the clinical and pathological findings of four gastric IHP cases. The lesions were mainly composed of hyperplastic foveolar-type glands with focal cystic dilatation. Pyloric type glands, endocrine cells, acinic cell metaplasia, and smooth muscle bundles were also seen as components of the polyp. Two cases (cases 1 and 4) coexisted with multifocal gastritis cystica profunda (GCP) and gastric adenocarcinoma. Case 4 furthermore exhibited an intermediate form between IHP and GCP. We suggest that IHP may be GCP associated with exaggeratedly hyperplastic and metaplastic changes. In case 4, the coexisting gastric carcinoma was mainly located in the submucosa, whilst the mucosal component was minimal. Five out of twenty reported gastric IHP cases, including our cases, coexisted with gastric adenocarcinoma. These facts would lead us to further investigate the relation between gastric IHP and carcinoma. (キーワード) Stomach / inverted / hyperplastic polyp / gastritis cystica profunda (出版サイトへのリンク) ● Publication site (DOI): 10.1034/j.1600-0463.2002.1101005.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12583438 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036819086 (DOI: 10.1034/j.1600-0463.2002.1101005.x, PubMed: 12583438, Elsevier: Scopus)
28.	山下理子, 廣川満良, 佐野壽昭, 蔭山武文 : 二次的変性を伴った側頭骨軟骨芽細胞腫の1例, 診断病理, Vol.19, No.1, 11-14, 2002年. (キーワード) chondroblastoma / temporal bone / S-100 protein / aneurysmal bone cyst / 変性 (degeneration)
29.	大西理子, 広川満良, 髙井チカ子, 山田順子, 三浦尚子, 古本博孝, 佐野壽昭 : Diff-Quik染色が診断に有用であった卵巣好酸性明細胞腺癌の1例, 診断病理, Vol.18, No.2, 159-161, 2001年. (キーワード) oxyphilic clear cell carcinoma / 卵巣 (ovary) / Diff-Quik stain / basement membrane / tigroid appearance
30.	若槻真吾, 廣川満良, 大西理子, 矢和田裕子, 広瀬隆則, 佐野壽昭 : 偽血管腔がみられなかった血管腫様悪性線維組織球腫の1例, 診断病理, Vol.18, No.2, 197-199, 2001年. (キーワード) soft tissue / angiomatoid malignant fibrous histiocytoma / pseudovascular space / desmin / CD99
31.	前田肇, 大西理子, 有岡一郎, 今脇節朗, 高沢有史, 山下洋一 : 左外側大腿回旋動脈瘤を伴う右破裂性大腿深動脈瘤の1例, 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery, Vol.5, No.4, 605-609, 1996年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570291226104925824 (CiNii: 1570291226104925824)

学術論文(紀要・その他):

1.	戸村美紀, 庄野仁志, 秋月裕則, 山下理子, 藤井義幸 : 当院で経験したアレルギー性真菌性鼻副鼻腔炎例, 徳島赤十字病院医学雑誌, Vol.25, No.1, 37-43, 2020年. (キーワード) アレルギー性真菌性副鼻腔炎 / 慢性副鼻腔炎 / 好酸球性副鼻腔炎 / allergic fungal rhinosinusitis / chronic sinusitis / eosinophilic sinusitis (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050003824755858688 (CiNii: 1050003824755858688)
2.	赤川洋子, 大塚秀樹, 大西範生, 谷勇人, 宇山直人, 武知克弥, 木下光博, 尾﨑享祐, 別宮浩文, 石橋直子, 原朋子, 尾崎敬治, 後藤哲也, 山下理子, 堀口英久 : ¹⁸ F-FDG-PET/CT検査が病期診断と治療効果判定に有用であった肺血管内リンパ腫の1症例, 徳島赤十字病院医学雑誌, Vol.24, No.1, 66-72, 2019年. (キーワード) ¹⁸ F-FDG-PET/CT / IVLBCL / 経気管支肺生検 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564288374020864 (CiNii: 1050564288374020864)
3.	渡邉俊介, 山下理子, 藤井義幸, 飛田泰斗史, 佐々木健介, 清家卓也 : 多彩な病理所見を呈し診断に苦慮したverrucous carcinoma の1例, 徳島赤十字病院医学雑誌, Vol.24, No.1, 73-76, 2019年. (キーワード) verrucous carcinoma / 好酸球浸潤 / 腫瘍関連組織好酸球増多 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282813397310848 (CiNii: 1050282813397310848)
4.	松崎紗弥, 山下理子, 藤井義幸, 髙嶋美佳, 石倉久嗣, 牛越賢治郎 : 正常妊娠後4年で発症した絨毛癌肺転移の1例, 徳島赤十字病院医学雑誌, Vol.23, No.1, 80-85, 2018年. (キーワード) 絨毛癌 / 肺転移 / hCG / total hCG / 正常妊娠 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050001338025101056 (CiNii: 1050001338025101056)
5.	岩佐紀子, 原朋子, 別宮浩文, 石橋直子, 尾崎敬治, 後藤哲也, 山下理子, 藤井義幸 : 関節リウマチに対するメトトレキサート治療中にサイトメガロウイルス胃潰瘍および血球貪食症候群を来した1例, 徳島赤十字病院医学雑誌, Vol.23, No.1, 67-73, 2018年. (キーワード) 関節リウマチ / サイトメガロウイルス胃潰瘍 / 血球貪食症候群 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282813001810816 (CiNii: 1050282813001810816)
6.	勢井伸幸, 渡辺光穂, 伊丹千尋, 多田遥香, 志水俊夫, 志水美沙, 庄野永恵, 上西知加子, 速水淳, 山下理子 : TAT(Turnaround Time)を考慮したCS‐2000i によるナノピアP-FDP・ナノピアDD 試薬の基礎検討, 徳島赤十字病院医学雑誌, Vol.22, No.1, 1-6, 2017年. (キーワード) TAT(Turnaround Time) / FDP / D ダイマー / 凝固検査検体取扱いに関するコンセンサス (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287978427520 (CiNii: 1050564287978427520)
7.	山下理子, 仁木寛, 浦野芳夫 : 検査部におけるISO9001をもとにした取り組み∼電子カルテ端末を利用した情報見える化・職員参画∼, 徳島赤十字病院医学雑誌, Vol.21, No.1, 109-120, 2016年. (キーワード) ISO15189 / ISO9001 / 臨床検査室 / 品質マネジメントシステム / 電子カルテ端末 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282813001716736 (CiNii: 1050282813001716736)
8.	多田遥香, 前田芳香, 上西知加子, 山下理子 : 市販鎮痛薬の長期服用により偽性高クロール血症を認めた1例, 徳島赤十字病院医学雑誌, Vol.20, No.1, 46-49, 2015年. (キーワード) 偽性高クロール血症 / ブロム / 中毒
9.	松田優子, 小野晃代, 中西一世, 畠山学, 増田有理, 藤井義幸, 山下理子 : HIV陰性 HHV‐8陰性患者の心嚢液に発生した原発性浸出液リンパ腫の1例, 徳島赤十字病院医学雑誌, Vol.20, No.1, 55-59, 2015年. (キーワード) PEL / HHV-8 / セルブロック
10.	久保田真理, 生越剛司, 渡邉力, 富本亜由美, 近藤理恵子, 谷口多嘉子, 七條光市, 高橋昭良, 中津忠則, 山下理子, 木村聡 : 治療中，posterior reversible encephalopathy syndrome(PRES)を合併した EB ウイルス関連血球貪食症候群の1例, 徳島赤十字病院医学雑誌, Vol.19, No.1, 99-102, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762952777344 (CiNii: 1050845762952777344)
11.	名護可容, 古本博孝, 祖川英至, 木内理世, 牛越賢治郎, 別宮史朗, 山下理子, 藤井義幸 : 子宮頸部癌肉腫の1症例, 徳島赤十字病院医学雑誌, Vol.19, No.1, 70-75, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762952774272 (CiNii: 1050845762952774272)
12.	松枝崇, 元木達夫, 来島敦史, 大谷享史, 福村好晃, 山下理子, 藤井義幸 : 局所的な大動脈解離による外傷性大動脈閉鎖不全症に対する1手術例, 徳島赤十字病院医学雑誌, Vol.19, No.1, 95-98, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287976065664 (CiNii: 1050564287976065664)
13.	山下雄太郎, 長江浩朗, 藤井義幸, 山下理子 : 切除術より20年後に再発した足部の筋血管周皮腫の1例, 徳島赤十字病院医学雑誌, Vol.19, No.1, 49-51, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287976062208 (CiNii: 1050564287976062208)
14.	住友弘幸, 沖津宏, 増田有理, 藏本俊輔, 松本大資, 富林敦司, 浜田陽子, 後藤正和, 湯浅康弘, 川中妙子, 石倉久嗣, 木村秀, 阪田章聖, 山下理子, 藤井義幸 : リンパ節転移を伴った Epstein-Barr virus 関連胃癌の1例, 徳島赤十字病院医学雑誌, Vol.19, No.1, 44-48, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282812999350400 (CiNii: 1050282812999350400)
15.	松本大資, 木村秀, 石倉久嗣, 松岡裕, 増田有理, 藏本俊輔, 富林敦司, 後藤正和, 浜田陽子, 湯浅康弘, 川中妙子, 沖津宏, 阪田章聖, 山下理子, 藤井義幸 : 長期間自然経過を追えた早期肺癌の1例, 徳島赤十字病院医学雑誌, Vol.19, No.1, 76-79, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050001338022642304 (CiNii: 1050001338022642304)
16.	村上尚嗣, 井上広基, 上田紗代, 中内佳奈子, 宮井優, 島田直, 金崎淑子, 新谷保実, 町田未央, 浦野芳夫, 山下理子, 藤井義幸 : 成人スティル病様の臨床経過を示し，破壊性甲状腺炎を合併した1例, 徳島赤十字病院医学雑誌, Vol.18, No.1, 79-83, 2013年. (キーワード) 成人スティル病 / 高フェリチン血症 / 破壊性甲状腺炎
17.	平井崇士, 浦野芳夫, 谷口千尋, 町田未央, 山下理子, 藤井義幸 : Vibrio vulnificus による壊死性筋膜炎の1剖検例, 徳島赤十字病院医学雑誌, Vol.18, No.1, 66-70, 2013年. (キーワード) 壊死性筋膜炎 / Vibrio vulnificus / アルコール性肝障害
18.	勢井伸幸, 松田優子, 妹尾彰之, 岩佐美沙, 西中和子, 森節子, 上西知加子, 仁木寛, 山下理子, 沖津宏 : D ダイマー偽高値の原因が患者血漿中のIgA と考えられた1症例, 徳島赤十字病院医学雑誌, Vol.18, No.1, 56-60, 2013年. (キーワード) D ダイマー / IgA / 非特異反応 / 偽高値
19.	山下雄太郎, 長江浩朗, 町田未央, 竹森千尋, 浦野芳夫, 山下理子, 藤井義幸 : アポクリン腺癌の1例, 徳島赤十字病院医学雑誌, Vol.18, No.1, 40-42, 2013年. (キーワード) アポクリン腺癌 / 腋窩 / 皮膚悪性腫瘍
20.	樫野千明, 山下理子, 藤井義幸, 沖津宏, 増田有理, 藏本俊輔, 松本大資, 松岡裕, 富林敦司, 浜田陽子, 湯浅康弘, 川中妙子, 石倉久嗣, 木村秀, 阪田章聖 : 病理解剖にて虫垂原発神経内分泌細胞癌・大細胞型と判明した1例, 徳島赤十字病院医学雑誌, Vol.18, No.1, 30-35, 2013年.
21.	大住真敬, 松枝崇, 元木達夫, 来島敦史, 大谷享史, 福村好晃, 藤井義幸, 山下理子 : 収縮性心膜炎に心膜嚢腫を合併した心不全症例に対する手術経験, 徳島赤十字病院医学雑誌, Vol.17, No.1, 128-131, 2012年. (キーワード) 収縮性心膜炎 / 心膜嚢腫 / 心膜剥皮術
22.	喜多健一郎, 沖津宏, 湯浅康弘, 古川尊子, 佐藤幸一, 山下理子, 沖津奈都 : 深達度sm でリンパ節転移を認めた直腸悪性黒色腫の1例, 徳島赤十字病院医学雑誌, Vol.17, No.1, 123-127, 2012年. (キーワード) 直腸悪性黒色 / 深達度sm / 腹腔鏡下腹会陰式直腸切断術 / リンパ節転移
23.	谷口千尋, 町田未央, 松立吉弘, 浦野芳夫, 木内慎一郎, 後藤田康夫, 沖津宏, 山下理子, 藤井義幸 : 内臓悪性腫瘍を合併した丘疹‐紅皮症(太藤)の2例, 徳島赤十字病院医学雑誌, Vol.17, No.1, 90-93, 2012年. (キーワード) 丘疹‐紅皮症 / 尿管癌 / 直腸癌 / 悪性腫瘍
24.	武市充生, 岩﨑英隆, 秋月裕則, 山下理子, 藤井義幸 : 急速に増大した舌下部神経鞘腫の1例, 徳島赤十字病院医学雑誌, Vol.17, No.1, 75-79, 2012年. (キーワード) 舌腫瘍 / 神経鞘腫 / 縫合補強材 / 吸収性ポリグリコール酸フェルト / ネオベール
25.	山下理子, 村澤恵美, 速水淳, 来島敦史, 木村秀, 藤井義幸 : 右下肢静脈血栓症で発症した平滑筋肉腫の1例, 徳島赤十字病院医学雑誌, Vol.17, No.1, 64-69, 2012年. (キーワード) 平滑筋肉腫 / 静脈血栓症 / 静脈エコー / 骨軟部腫瘍
26.	渡邉力, 生越剛司, 谷口多嘉子, 近藤梨恵子, 七條光市, 松下正民, 高橋昭良, 中津忠則, 岡博文, 三宅一, 尾﨑享祐, 山下理子, 後藤哲也, 原田みどり : 1st line で自家末梢血幹細胞移植を施行した頭蓋内胚細胞性腫瘍(Yolk sac tumor)の1例, 徳島赤十字病院医学雑誌, Vol.17, No.1, 33-38, 2012年. (キーワード) 脳胚細胞性腫瘍 / 卵黄嚢がん / 大量化学療法 / 自家末梢血幹細胞移植 / プラチナ製剤
27.	久保田真理, 沖津宏, 松本大資, 古川尊子, 木原歩美, 松岡裕, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, 吉岡一夫, 山下理子, 藤井義幸 : 幽門輪温存腹腔鏡下幽門側胃切除を行った極めてまれな胃間葉系腫瘍の1例, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 106-110, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762951894784 (CiNii: 1050845762951894784)
28.	平尾章博, 宮井優, 近藤絵里, 金崎淑子, 新谷保実, 宮恵子, 武市充生, 岩﨑英隆, 秋月裕則, 木内慎一郎, 上間健造, 山下理子, 藤井義幸, 藤野修 : 2型糖尿病発症から10年を経て発症したIgG4関連疾患の1例, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 82-87, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762951888256 (CiNii: 1050845762951888256)
29.	岡西大介, 沖津宏, 松本大資, 古川尊子, 松岡裕, 木原歩美, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, 山下理子, 藤井義幸 : 神経内分泌成分を含む横行結腸低分化腺癌の1例, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 35-40, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762951880704 (CiNii: 1050845762951880704)
30.	辻真一郎, 沖津宏, 松本大資, 古川尊子, 木原歩美, 松岡裕, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, 藤井義幸, 山下理子 : 術前化学療法が奏効したAFP産生胃癌の2例, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 99-105, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287975182720 (CiNii: 1050564287975182720)
31.	福田靖, 加藤道久, 藏本俊輔, 山本香, 中井香, 當別當庸子, 箕田直治, 郷律子, 山下理子, 藤井義幸, 神山有史 : 心原性心停止が原因と考えられた34歳女性の溺水例, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 88-92, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282812998468736 (CiNii: 1050282812998468736)
32.	辻岡卓也, 沖津宏, 松本大資, 古川尊子, 松岡裕, 木原歩美, 浜田陽子, 湯浅康弘, 石倉久嗣, 木村秀, 阪田章聖, 山下理子, 藤井義幸, 吉岡一夫 : 肺癌術後に発症し，鏡視下手術を行った下行結腸癌，AFP産生胃癌の異時性3重複癌の1例, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 93-98, 2011年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050001338021759104 (CiNii: 1050001338021759104)
33.	堤聡, 木村秀, 松本大資, 古川尊子, 松岡裕, 木原歩美, 浜田陽子, 湯浅康弘, 石倉久嗣, 沖津宏, 阪田章聖, 山下理子, 藤井義幸 : 診断に苦慮したリポイド肺炎の1例, 徳島赤十字病院医学雑誌, Vol.16, No.1, 124-127, 2011年. (キーワード) リポイド肺炎 / 泡沫状マクロファージ / 胸腔鏡下肺生検
34.	奈路田拓史, 笠井利則, 上間健造, 山下理子, 藤井義幸 : 巨大精巣癌の1例, 徳島赤十字病院医学雑誌, Vol.15, No.1, 95-99, 2010年. (キーワード) 巨大精巣癌 / 胚細胞腫瘍 / セミノーマ
35.	笹弥生, 尾崎敬治, 石橋直子, 原朋子, 後藤哲也, 藤井義幸, 山下理子 : 播種性トリコスポロン症を来した造血器腫瘍患者の2剖検例, 徳島赤十字病院医学雑誌, Vol.15, No.1, 65-69, 2010年. (キーワード) 播種性トリコスポロン症 / ミカファンギン / 造血器腫瘍 (hematological malignancy) / ブレークスルー感染
36.	岩佐美沙, 湊真子, 森川朋美, 加藤邦子, 浜井和子, 山下理子, 小野晃代, 中西一世, 廣瀬彬, 杉本真弓, 生越剛司, 渡邉力, 吉田哲也 : 日本海裂頭条虫症の2例, 徳島赤十字病院医学雑誌, Vol.15, No.1, 60-64, 2010年. (キーワード) 虫卵検査 / 日本海裂頭条虫 / 病理組織検査
37.	梅本多嘉子, 近藤梨恵子, 七條光市, 杉本真弓, 生越剛司, 渡邉力, 中津忠則, 吉田哲也, 岡博文, 三宅一, 城野良三, 山下理子, 藤井義幸 : 急性リンパ性白血病治療終了後から7年後に発症した anaplastic astrocytoma の1例, 徳島赤十字病院医学雑誌, Vol.15, No.1, 45-49, 2010年. (キーワード) anaplastic astrocytoma / ALL / 二次がん / 放射線照射 / temozolomide
38.	中内佳奈子, 野々木理子, 山本英司, 島田直, 後藤田康夫, 吉田智則, 佐藤幸一, 長田淳一, 中野誠一, 山下理子, 藤井義幸, 片岡孝一 : ミクリッツ病診断を契機に発見された自己免疫性膵炎の1症例中, 徳島赤十字病院医学雑誌, Vol.15, No.1, 55-59, 2010年. (キーワード) 自己免疫性膵炎 / IgG4関連疾患 / ミクリッツ病
39.	長江浩朗, 仙崎雄一, 藤井義幸, 山下理子 : 皮膚側と粘膜側からの前進皮弁による下口唇再建の経験, 徳島赤十字病院医学雑誌, Vol.14, No.1, 122-128, 2009年. (キーワード) 下口唇再建 / 前進皮弁 / V-Y advancement flap / 有棘細胞癌
40.	山下理子, 高見京子, 浜井和子, 中西一世, 藤井義幸, 別宮史朗, 猪野博保 : 卵巣リンパ管腫の破たんによると思われた乳び様腹水の1症例, 徳島赤十字病院医学雑誌, Vol.14, No.1, 101-104, 2009年. (キーワード) 卵巣 (ovary) / リンパ管腫 / 乳び腹水 / 細胞診
41.	浦野芳夫, 松田里恵, 齋藤聖子, 山下理子, 城野良三, 清水公博, 桝田勝仁 : 高齢者に発症した皮膚腺病の1例, 徳島赤十字病院医学雑誌, Vol.14, No.1, 66-69, 2009年. (キーワード) 皮膚結核 / リンパ節結核 / 抗結核剤
42.	奈路田拓史, 笠井利則, 上間健造, 湊拓也, 阪田章聖, 山下理子, 藤井義幸 : 腎摘後5日目に結腸穿孔を生じた黄色肉芽腫性腎盂腎炎の1例, 徳島赤十字病院医学雑誌, Vol.14, No.1, 56-61, 2009年. (キーワード) 黄色肉芽腫性腎盂腎炎 / 腎摘 / 結腸穿孔
43.	齋藤聖子, 松田里恵, 浦野芳夫, 山下理子, 藤井義幸, 福原耕作 : 皮膚ノカルジア症の1例, 徳島赤十字病院医学雑誌, Vol.13, No.1, 96-99, 2008年. (キーワード) ノカルジア / 限局型 / 菌塊
44.	田中麻美, 湊拓也, 山村陽子, 片山和久, 石倉久嗣, 一森敏弘, 石川正志, 沖津宏, 木村秀, 阪田章聖, 山下理子, 藤井義幸 : 非外傷性脾破裂にて発見された悪性リンパ腫の1例, 徳島赤十字病院医学雑誌, Vol.13, No.1, 91-95, 2008年. (キーワード) 脾破裂 / 悪性リンパ腫 / カテーテル塞栓術
45.	長尾紀昭, 山下理子, 近藤絵里, 原朋子, 尾崎敬治, 後藤哲也, 藤井義幸 : 膠芽腫との鑑別が困難であった脳原発悪性リンパ腫の1解剖例, 徳島赤十字病院医学雑誌, Vol.13, No.1, 43-48, 2008年. (キーワード) 脳原発悪性リンパ腫 / 膠芽腫 / びまん性大細胞型B 細胞リンパ腫
46.	松田里恵, 浦野芳夫, 笠井利則, 奈路田拓史, 上間健造, 山下理子 : アンピシリンによる acute generalized exanthematous pustulosis の1例, 徳島赤十字病院医学雑誌, Vol.12, No.1, 45-47, 2007年. (キーワード) acute generalized exanthematous pustulosis / アンピシリン/スルバクタム / 薬疹
47.	溝木智子, 日浅芳一, 宮崎晋一郎, 小倉理代, 宮島等, 尾原義和, 弓場健一郎, 鈴木直紀, 高橋健文, 細川忍, 岸宏一, 大谷龍治, 元木達夫, 吉田誉, 大谷亨史, 福村好晃, 山下理子, 藤井義幸 : 心不全を契機に発見された孤発性マルファン症候群の1例, 徳島赤十字病院医学雑誌, Vol.11, No.1, 85-90, 2006年.
48.	松田里恵, 七條光市, 浦野芳夫, 山下理子, 藤井義幸, 廣瀬政寛 : Premalignant fibroepithelial tumor の1例, 徳島赤十字病院医学雑誌, Vol.11, No.1, 82-84, 2006年. (キーワード) Premalignant Fibroepithelial Tumor / Pinkus / 腫瘍
49.	奈路田拓史, 笠井利則, 上間健造, 池山鎮夫, 谷勇人, 大西範生, 城野良三, 山下理子, 藤井義幸 : 腎盂自然破裂をきたした左尿管癌の1例, 徳島赤十字病院医学雑誌, Vol.11, No.1, 100-105, 2006年. (キーワード) 尿管癌 / 腎盂自然破裂 / 腎周囲出血
50.	大西理子, 榊美佳, 田中靖, 廣川満良, 佐野壽昭, 石橋広樹, 嵩原裕夫 : 【内分泌病理学最近の進歩2002】副腎髄質と傍神経節から同時発生した小児褐色細胞腫, ホルモンと臨床, Vol.50, No.suppl., 200-205, 2002年. (キーワード) 褐色細胞腫 / 小児 (infant) / X線CT / 副腎腫瘍 / 副腎髄質 / 傍神経節

学術レター:

1.	Yusaku Maeda, Shoichiro Takao, Shiori Morita, Shin Kondo, Michiko Yamashita, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, Mamiko Takahashi, Shiroh Fujii, Takeshi Harada, Hirokazu Miki, Masahiro Abe and Shingen Nakamura : Quality of skeletal muscles during allogeneic stem-cell transplantation: a pilot study, BMJ Supportive & Palliative Care, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.1136/spcare-2024-005070 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1136/spcare-2024-005070 (DOI: 10.1136/spcare-2024-005070)
2.	Yasutoshi Hida, Riho Nakano, Ryouga Yuasa, Kanna Maehama, Michiko Yamashita and Yoshio Urano : Erythema gyratum repens-like presentation of folliculotropic mycosis fungoides, Dermatology Online Journal, Vol.30, No.1, 22, 2024. (キーワード) erythema gyratum repens / folliculotropic / gamma chain / 免疫組織化学 (immunohistochemistry) / mycosis fungoides / mycosis fungoides / polymerase chain reaction / T cell receptor (出版サイトへのリンク) ● Publication site (DOI): 10.5070/D330163304 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.5070/D330163304 (DOI: 10.5070/D330163304)
3.	Yasutoshi Hida, Riho Kageji, Hirofumi Bekku, Shunsuke Watanabe, Takuya Seike and Michiko Yamashita : Cutaneous T-cell lymphoma developing during nivolumab treatment for metastatic melanoma., Dermatology Online Journal, Vol.28, No.1, 2022. (キーワード) Humans / Lymphoma, T-Cell, Cutaneous / Melanoma / Neoplasms, Second Primary / Nivolumab / Skin Neoplasms (徳島大学機関リポジトリ) ● Metadata: 117441 (出版サイトへのリンク) ● Publication site (DOI): 10.5070/D328157071 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35499424 ● Summary page in Scopus @ Elsevier: 2-s2.0-85129178701 (徳島大学機関リポジトリ: 117441, DOI: 10.5070/D328157071, PubMed: 35499424, Elsevier: Scopus)
4.	Takako Umemoto, Tsutomu Watanabe, Takeshi Ogose, Rieko Kondo, Tadanori Nakatsu, Akiyoshi Sakata, Michiko Yamashita and Tetsuya Gotho : Capillary leak syndrome: initial presentation in a patient with ALK+anaplastic large cell lymphoma associated with increased levels of serum cytokines., Leukemia & Lymphoma, Vol.52, No.6, 1139-1142, 2011. (キーワード) Adolescent / Anaplastic Lymphoma Kinase / Capillary Leak Syndrome / Cytokines / Granulocyte Colony-Stimulating Factor / Humans / Interferon-gamma / Interleukin-10 / Interleukin-6 / Lymphoma, Large-Cell, Anaplastic / Male / Receptor Protein-Tyrosine Kinases (出版サイトへのリンク) ● Publication site (DOI): 10.3109/10428194.2011.555893 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21463119 ● Search Scopus @ Elsevier (PMID): 21463119 ● Search Scopus @ Elsevier (DOI): 10.3109/10428194.2011.555893 (DOI: 10.3109/10428194.2011.555893, PubMed: 21463119)

総説・解説:

1.	市島諒二, 山下理子, 後藤田卓志 : 消化管症候群(第3版) II ―その他の消化管疾患を含めて― IV 虫垂虫垂内分泌細胞癌, 日本臨牀, Vol.10, 228-231, 2020年2月. (キーワード) 神経内分泌腫瘍 / 虫垂 / WHO分類
2.	常山幸一, 清水真祐子, 尾矢剛志, 松本穣, 小林智子, 小川博久, 西辻和親, 山下理子 : 肝臓病理所見のとり方とその解釈, 法医病理, Vol.25, No.1, 1-12, 2019年7月.
3.	山下理子 : 臨床検査専門医がコッソリ教える⋯検査のTips! 第15回．ホルマリン固定すればすべて診断できる?, レジデントノート, Vol.20, 569-571, 2018年6月.
4.	山下理子 : びょうり(顕微鏡)検査と，がんのおくすり．, 四国医学雑誌, Vol.74, No.1, 7-12, 2018年4月. (要約) The aging rate of the Tokushima prefecture is reaching globally top levels, while its cancer morbidity rate also rises. Malignant tumors can develop from almost any site in the body. Each tumor has unique, individual growth speeds. In pathological examination, a histological name is determined as ditailedly as possible to clarify the growth pattern and the treatment strategy of the tumor. Malignant tumors can be lethal, but according to one study they hardly require prolonged nursing care.Histological diagnosis requires the following procedures : tumor identification, surgical dissection, fixing, dehydration, paraffin embedding, thin sectioning, staining, sealing, labeling and microscopic observation. Formalin-fixed paraffin embedded blocks, which help in the indication of molecular targeted drugs are generated through these processes. Since many targeted therapies block the EGFR-RAS-MAPK pathway, it is potentially one of the main mechanisms of cancer growth.Our most urgent needs include appropriate explanations about variety and "draggability" of the cancers and cultivating patients' "will to live." To maintain the dignity of cancer patients, we must assemble a fully developed cancer team that includes active pathologists in each local community. (キーワード) 癌 (cancer) / pathology / formalin-fixed paraffin embedded block / FFPE / molecular targeted drugs (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050865122807063296 (CiNii: 1050865122807063296)
5.	山下理子, 藤井義幸, 後藤哲也 : なるほどわかった!日常診療のズバリ基本講座.∼研修医のためのCPC発表準備のポイント∼, レジデントノート, Vol.16, 721-728, 2014年6月.

国際会議:

1.	Hiroto Nishio, Yuko Narusawa, Kensaku Aki, Motoki Sugasaki, Takayuki Nakao, Takeshi Oya and Michiko Yamashita : Efficacy of Aether AIHema in Teaching Clinical Hematology to Undergraduate Medical Laboratory Science Students, ASCPaLM 2024, Seoul, Sep. 2024.
2.	Michiko Yamashita, Sarina Takeuchi, Mizuki Fujii, Hikaru Nishizoe, Mai Kanai, Yuko Matsuda, Nobuyuki Sei, Mitsuho Watanabe and Takahiko Kasai : Biochemical Markers Correlated to Gelationous Degeneration of Bone Marrow: An Autopsy Study, ANNALS OF LABORATORY MEDICINE, Vol.Supplement, No.42, S63, Seoul, Oct. 2022. (キーワード) 骨髄膠様変性 / 漿液性萎縮 / 骨髄 / 悪液質 / たんぱく質・エネルギー欠乏(症)

国内講演発表:

1.	村井純平, 中村信元, 辻誠士郎, 山下理子, 上原久典, 滝下誠 : 著明な腹水貯留と腎機能障害で発症し Fluid Overload-associated Large B cell lymphoma(FO-LBCL)と思われた1例, 第129回日本内科学会四国地方会,
2.	西尾碩人, 成澤裕子, 山下理子 : 成人T細胞性白血病の皮膚・リンパ節病変におけるCD3/7, CD7/25免疫二重染色の有用性の検討, 日本臨床検査医学会雑誌, 2024年11月.
3.	宮上侑子, 住田智志, 高山良政, 坂東良美, 上原久典, 山下理子 : T細胞受容体遺伝子再構成を示し，皮膚に再発した結節硬化型古典的ホジキンリンパ腫の一例, 日本リンパ網内系学会会誌, 2024年6月.
4.	蔭山武史, 紀本彩佳, 厚美憲吾, 柿本拓海, 小林智子, 山下理子, 坂東良美, 上原久典, 竹内賢吾 : 皮膚病変を生じた芽球性形質細胞様樹状細胞腫瘍の4例, 第113回日本病理学会総会, 2024年3月.
5.	藤丸良, 常松貴明, 常山幸一, 山下理子 : 重症低血糖を呈したIGF-2 産生肝細胞癌の1例, 日本病理学会会誌, 2024年3月.
6.	山下菜々美, 瀧井友梨恵, 大原菜摘, 成澤裕子, 小野晃代, 中西一世, 渡邉俊介, 笠井孝彦, 桑山泰治, 片㘴諒, 森河由里子, 坂東良美, 上原久典, 山下理子 : 原発不明癌の腹膜播種と考えらえた一例, 徳島臨床細胞学会学術集会抄録集, 2024年3月.
7.	大原菜摘, 山下由美子, 倍味歩実, 中村信元, 小川博久, 常山幸一, 山下理子 : Fluid overload large B cell lymphoma FO-LBCLとの鑑別を要した腹水plasmacytosisの1例, 四国医学雑誌, Vol.79, No.5-6, 277, 2024年3月.
8.	大原菜摘, 山下由美子, 倍味歩実, 中村信元, 小川博久, 常山幸一, 山下理子 : Fluid overload large B cell lymphoma FO-LBCLとの鑑別を要した腹水 plasmacytosisの1例, 第267回徳島医学会学術集会, 2023年8月.
9.	藤丸良, 山下理子, 常松貴明, 福田いずみ, 玉木克佳, 常山幸一 : 腫瘍随伴症状としての NICTH を伴う IGF-2 産生性肝細胞癌, 第267回徳島医学会学術集会, 2023年8月.
10.	厚美憲吾, 松本穣, 山下理子, 西村碧フィリーズ, 佐藤康晴, 坂東良美, 上原久典 : リンパ節病変, 第141回日本病理学会中国四国支部学術集会スライドカンファレンス, 2023年6月. (キーワード) 成人T細胞白血病
11.	桒原周爾, 勢井伸幸, 志水俊夫, 渡辺光穂, 西川真由, 速水淳, 山下理子 : i-densy を用いて髄液検体から MYD88L265P 遺伝子変異を検出した DLBCL の一例, 医学検査, 2023年5月.
12.	重清咲良, 米澤彩花, 宮上侑子, 松田優子, 小野晃代, 中西一世, 畠山学, 上田利和, 渡邉俊介, 笠井孝彦, 桒原周爾, 渡辺光穂, 勢井伸幸, 藤井義幸, 山下理子 : 遺伝子変異を検出しえた中枢神経系原発リンパ腫の一例, 徳島県臨床細胞学会学術集会抄録集, 2023年3月.
13.	梶野晃未, 生島仁史, 佐々木幹治, 大谷環樹, 山下理子, 芳賀昭弘 : 放射線治療効果を早期に検出できるRadiomics特徴量の探索, 日本放射線腫瘍学会第35回学術大会, 2022年11月.
14.	山下理子, 錦織亜沙美, 佐藤康晴, 渡邉俊介, 吉野正 : 抗 PD-1 抗体薬(オプジーボ)治療後に 2 つの異なる皮膚 CD8+T 細胞リンパ腫を発症した症例, 日本病理学会会誌, Vol.111, No.1, 86, 2022年4月.
15.	渡邉俊介, 富田満, 山下理子, 笠井孝彦, 藤井義幸 : 胃病変, 日本病理学会中国四国支部学術集会抄録集, 7, 2022年2月.
16.	勢井伸幸, 志水俊夫, 渡辺光穂, 西川真由, 桑原周爾, 速水淳, 山下理子 : 小児における急性骨髄性白血病，非特異型(FAB分類M6)の1症例, 日本検査血液学会雑誌, Vol.22, S34, 2021年9月.
17.	山下理子 : パネルディスカッション05 「臨床栄養における臨床検査値(体組成も含めて)の理解とRCPC(reversed clinico-pathological conference)の意義を考える」, 学会誌JSPEN, Vol.1, No.supplement, 2021年7月.
18.	山下理子, 常山幸一, 尾矢剛志 : 骨髄膠様変性時の造血微小環境について, 日本病理学会会誌, Vol.110, No.1, 355, 2021年4月.
19.	六車京香, 近藤和也, 副島志帆, Bilguun tegshee, 山下理子, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 : 胸腺上皮性腫瘍におけるMT1A遺伝子のDNAメチル化とmRNA発現, 第40回日本胸腺研究会, 2021年2月.
20.	渡邉俊介, 宮上侑子, 山下理子, 藤井義幸 : 軟部腫瘍, 第 133 回日本病理学会中国四国支部学術集会(スライドカンファレンス), 2020年11月.
21.	渡辺力, 高橋昭良, 七條光市, 岡田朝美, 松本苑美, 武知敦美, 高見容子, 藤野修司, 谷口多嘉子, 中津忠則, 山下理子 : 全身型若年性特発性関節炎の診断時における骨髄検査の意義, 日本小児科学会雑誌, Vol.124, No.11, 1664, 2020年11月.
22.	赤川洋子, 宇山直人, 武知克弥, 木下光博, 大西範生, 尾崎享祐, 谷勇人, 大塚秀樹, 石橋直子, 別宮浩文, 原朋子, 尾崎敬治, 後藤哲也, 山下理子 : 子宮原発びまん性大細胞型B細胞性リンパ腫の1例, Japanese Journal of Radiology, Vol.38, No.Suppl, 71, 2020年2月.
23.	湯浅康弘, 福田美月, 牧秀則, 藤本啓介, 竹内大平, 常城宇生, 松尾祐太, 森理, 江藤祥平, 藤原聡史, 富林敦司, 石倉久嗣, 山下理子, 藤井義幸 : 胃に穿通し瘻孔形成した横行結腸癌の一例, 日本消化管学会雑誌, Vol.4, No.Suppl, 321, 2020年1月.
24.	尾矢剛志, 松本穣, 香川典子, 山下理子, 小川博久, 常山幸一 : 小腸腫瘍の1例, 日本病理学会中国四国支部学術集会第130回スライドカンファレンス, 2019年10月.
25.	久保美和, 渡邉俊介, 山下理子, 尾矢剛志, 常山幸一 : 子宮頸部病変, 日本病理学会中国四国支部学術集会第128回スライドカンファレンス, 2019年2月.
26.	山下理子, 若槻真吾, 遠藤早希子, 佐竹宣法, 堀口英久, 小川博久, 常山幸一 : 「病理夏の学校in徳島」における，検査値解析を用いた全学年参加CPC, 日本病理学会会誌, Vol.106, No.1, 327, 2017年3月.
27.	町田未央, 谷口千尋, 杉野博崇, 長江浩朗, 山下理子, 山本忠正, 浦野芳夫 : 乳児に生じた隆起性皮膚繊維肉腫の1例, 第111回日本皮膚科学会総会, 2012年6月.
28.	香川聖子, 堀口英久, 山下理子, 藤井義幸, 坂下直実 : 心不全病態における糖質コルチコイド受容体発現の意義:剖検心を用いた人体病理学的研究, 第101回日本病理学会, 2012年4月.
29.	岩﨑英隆, 武市充生, 山下理子, 藤井義幸, 秋月裕則 : 頸部リンパ節に発生した胚中心進展性異形成の2症例, 第73回耳鼻咽喉科臨床学会, 2011年6月.
30.	湊拓也, 沖津宏, 田中麻美, 山村陽子, 片山和久, 木村秀, 坂田章聖, 山下理子, 藤井義幸, 丹黒章, 伊藤孝司, 伊崎俊介, 高野正志 : TS-1の術前2週投与により著効がえられた進行胃癌の2症例, 第80回日本胃癌学会総会, 2008年2月.
31.	湊拓也, 沖津宏, 田中麻美, 山村陽子, 片山和久, 木村秀, 坂田章聖, 山下理子, 藤井義幸, 丹黒章, 伊藤孝司, 伊崎俊介, 高野正志 : TS-1の術前2週投与によりほぼCRがえられた進行胃癌の1症例, 第82回中国四国外科学会総会, 2007年9月.
32.	Ken-ichi Aihara, Masashi Akaike, Hiroyuki Azuma, Toshio Matsumoto, Michiko Yamashita, Yoshimura Kimihiro and Imagawa Jun-ichi : Elevated blood pressure with a cardiovascular remodeling in mice lacking vitamin D receptor, 第66回日本循環器学会総会・学術集会, Apr. 2002.

その他・研究会:

1.	重清咲良, 米澤彩花, 髙尾正一郎, 成澤裕子, 山下理子 : Bz-X800 Analyzerを用いた骨髄脂肪細胞の定量的解析の試み, 徳島県臨床衛生検査技師会誌, 19, 2023年12月.
2.	米澤彩花, 重清咲良, 成澤裕子, 山下理子 : 骨髄外脂肪における膠様変性の検討, 徳島県臨床衛生検査技師会誌, 18, 2023年12月.
3.	藤井観月, 西添ひかる, 竹内紗里奈, 山下理子 : 骨髄線維化を伴った膠様変性とCAR細胞, 徳島県臨床検査技師会誌, 25, 2022年12月.
4.	西添ひかる, 藤井観月, 中村信元, 髙尾正一郎, 山下理子 : 血液疾患における筋肉量，脂肪量の検討, 徳島県臨床検査技師会誌, 24, 2022年12月.
5.	山下理子 : がんゲノム医療市中病院の立場から, 徳島大学大学院医歯薬研究部シンポジウム, 2021年12月.
6.	秦耕太, 湯浅凌雅, 竹内紗里奈, 山下理子, 尾矢剛志, 常山幸一, 清水真祐子 : 骨髄膠様変性時，臨床検査値と造血幹細胞ニッチはどう変化しているか, 徳島県臨床検査技師会誌, 28, 2021年12月.
7.	湯浅凌雅, 秦耕太, 竹内紗里奈, 山下理子, 住谷龍平, 上原久典, 坂東良美, 常山幸一 : 同種骨髄移植後の造血微小環境についての病理学的研究, 徳島県臨床検査技師会誌, 27, 2021年12月.
8.	竹内紗里奈, 小林由利恵, 山下理子, 尾矢剛志, 常山幸一 : 骨髄膠様変性における造血ニッチ形成細胞についての免疫組織化学的研究, 徳島県臨床検査技師会誌, 18, 2020年12月.
9.	小林由利恵, 竹内紗里奈, 山下理子, 常山幸一, 清水真祐子 : 骨髄膠様変性と相関する臨床検査値の統計学的研究, 徳島県臨床検査技師会誌, 19, 2020年12月.

報告書:

1.	石川正志, 松岡裕, 垣本歩美, 田中麻美, 湊拓也, 山村陽子, 石倉久嗣, 一森敏弘, 木村秀, 阪田章聖, 山下理子, 藤井義幸, 池山鎮夫, 谷勇人, 大西範夫, 城野良三 : 胆嚢十二指腸瘻を形成した胆石症例の検討, 臨床と研究, Vol.85, No.12, 1765-1768, 福岡, 2008年12月.
2.	岡村誠介, 木村哲夫, 矢野弘美, 井本佳孝, 梶雅子, 青木利佳, 佐藤康紀, 宮本弘志, 六車直樹, 伊東進, 山下理子, 佐野壽昭, 池本哲也, 藤井正彦, 三宅秀則 : 膵管内発育を主とし特異な形態を呈した膵腺房細胞癌の1例, 消化器画像, Vol.9, No.1, 41-46, 2007年1月.
3.	米田亜樹子, 佐野壽昭, 久元恵美子, 山下理子, 山田正三 : Folliculostellate cell(FSC)の極めて豊富な下垂体腺腫, 日本内分泌学会雑誌, Vol.81, No.2, 585-586, 2005年9月.
4.	廣川満良, 山下理子, 佐野壽昭, 加島健司 : Ki-67 labeling indexが高値を示す部分が多発性にみられた非浸潤性多形腺腫内癌の1例, 日本唾液腺学会抄録集, 36-37, 2004年12月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

レディオミクス画像解析に基づく新たな放射線治療戦略構築に資する研究 (研究課題/領域番号: 23K07158 )
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准教授 : 山下理子