Tokushima University / Educator and Researcher Directory --- Yoshinaga, Kaoru

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1.	Ryoko Shioyasono, Atsushi Shioyasono, Ayami Ito, Kaoru Yoshinaga, Soichiro Kinjo, Keiichiro Watanabe, Masahiro Hiasa, Natsumi Takamaru and Eiji Tanaka : A patient with unilateral posterior crossbite treated with modified unilateral surgically-assisted rapid maxillary expansion., AJO-DO Clinical Companion, Vol.3, No.2, 149-162, 2023. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.xaor.2023.02.001 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.xaor.2023.02.001 (DOI: 10.1016/j.xaor.2023.02.001)
2.	Ryoko Shioyasono, Kaoru Yoshinaga, Atsushi Shioyasono, Ayami Ito, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka : Nonsurgical orthodontic treatment for a patient with Sotos syndrome., American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO), Vol.163, No.3, 426-442, 2023. (Summary) Sotos syndrome is a genetic disorder characterized by overgrowth in childhood, specific facial manifestations, advanced bone age, and mental retardation. The purpose of this article is to describe the nonsurgical orthodontic treatment of a 10-year-old boy with a skeletal mandibular protrusion, unilateral posterior crossbite, and Sotos syndrome. After maxillary lateral expansion, the skeletal Class III relationship with an anterior crossbite improved because of mandibular clockwise rotation, whereas the facemask had a marginal effect. After growth at 16 years, he had a skeletal Class I relationship, and thus, conventional orthodontic treatment with preadjusted edgewise appliances was initiated. After 41 months of multibracket treatment, acceptable occlusion with a functional Class I relationship was obtained. One year postretention, few changes in occlusion and facial features were observed. Our results demonstrate that considering the maxillofacial vertical growth during the peripubertal period associated with Sotos syndrome, more attention should be paid to the early orthopedic treatment with the facemask and/or chincap. (Keyword) male / Humans / children / Malocclusion, Angle Class III / Sotos Syndrome / Cephalometry / Malocclusion / Mandible / Palatal Expansion Technique / Extraoral Traction Appliances / Maxilla (Tokushima University Institutional Repository) ● Metadata: 118746 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ajodo.2021.11.021 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36437146 ● CiNii @ National Institute of Informatics (CRID): 1050298278494326144 ● Summary page in Scopus @ Elsevier: 2-s2.0-85142425693 (Tokushima University Institutional Repository: 118746, DOI: 10.1016/j.ajodo.2021.11.021, PubMed: 36437146, CiNii: 1050298278494326144, Elsevier: Scopus)
3.	Kaoru Yoshinaga, Akihiro Yasue, Silvia Naomi Mitsui Akagi, Yoshiyuki Minegishi, Seiichi Oyadomari, Issei Imoto and Eiji Tanaka : Double Mutations on Tooth Development., Genes, Vol.14, No.2, 2023. (Summary) and that the interaction between the two genes functions in conjunction with other ligands to control the spatial patterning and development of teeth. (Keyword) Animals / Humans / knockout mice / cell proliferation and differentiation / Mutation / Nerve Tissue Proteins / Odontogenesis / Phenotype / Proto-Oncogene Proteins / Tooth / Wnt Proteins (Tokushima University Institutional Repository) ● Metadata: 118370 (Link to Publication Site) ● Publication site (DOI): 10.3390/genes14020340 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36833267 ● Search Scopus @ Elsevier (PMID): 36833267 ● Search Scopus @ Elsevier (DOI): 10.3390/genes14020340 (Tokushima University Institutional Repository: 118370, DOI: 10.3390/genes14020340, PubMed: 36833267)
4.	Kaoru Yoshinaga, 塩屋園玲子, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka : 歯科矯正用アンカースクリューの導入に伴う治療方針の変化(第一報) 抜歯・非抜歯および抜歯部位の判定に関する検討, The Journal of Chu-Shikoku Orthodontic Society, Vol.33, No.1, 19-28, 2021. (Summary) 【目的】近年，歯科矯正用アンカースクリュー(以降アンカーと明記する)の普及により，臼歯の固定や移動が容易に行えるようになり，抜歯，非抜歯，抜歯部位の選択についても変化が起きている．今回，アンカーの導入前後での治療方針の変化について，とくに臼歯抜歯の適応に関する調査を行ったので報告する．【方法】徳島大学病院矯正歯科を受診した初診時年齢12歳以上の患者を対象とし，2002年以前にマルチブラケット治療の診断を受けた100名(Pre群)と2008年以降に診断を受けた100名(Post群)を無作為に抽出した．先天性疾患および歯牙欠損症例，顎変形症は除外した．診断内容における臼歯抜歯(第三大臼歯は除く)の有無，抜歯部位等に関する比較検討を行った．【結果および考察】Pre群とPost群の間で抜歯症例数および抜歯部位に違いは認められなかった．一方，skeletal Class IIの症例はPre群では上顎片顎小臼歯抜歯によるカムフラージュ治療が多かったのに対し，Post群ではその割合は減少していた．また，skeletal Class IIIの症例ではアンカーを用いた非抜歯治療の割合が増加していた．High mandibular plane angle caseにおいてはアンカーの使用により，上顎第一大臼歯の挺出防止ならびに圧下が可能となり上下顎第一小臼歯を抜去する割合が増えた．【結論】アンカー導入で，臼歯の移動や挺出の防止および圧下が可能となり抜歯部位の選択基準に変化が生じたと考えられた．(著者抄録) (Keyword) 下顎骨上顎骨小臼歯(外科的療法) 抜歯不正咬合-アングルI級(治療) 不正咬合-アングルII級(治療) 不正咬合-アングルIII級(治療) 治療成績歯科矯正用固定源埋込みヒト歯学
5.	Susumu Abe, Miyagi Akane, Kaoru Yoshinaga, Yoshizo Matsuka, Fumihiro Matsumoto, Uyama Emi, Yoshitaka Suzuki, Masamitsu Ohshima, Kazuo Okura and Eiji Tanaka : Immediate Effect of Masticatory Muscle Activity with Transcutaneous Electrical Nerve Stimulation in Muscle Pain of Temporomandibular Disorders Patients, Journal of Clinical Medicine, Vol.9, No.10, 3330, 2020. (Summary) Transcutaneous electrical nerve stimulation (TENS) is a non-invasive treatment modality for acute and chronic pain. However, little information for muscle activity is available on the immediate effects of TENS in masticatory muscle pain related to temporomandibular disorders (TMDs). The present study aimed to evaluate the immediate effects of TENS treatment on TMD-related muscle pain. Thirty-six patients with TMD-related muscle pain and 39 healthy subjects served as TMD and control groups, respectively. For objective evaluations, maximum mouth opening, and maximum bite force were measured before and after TENS. The pain intensity was assessed according to a 100-mm visual analog scale (VAS). TENS was applied to painful muscles for 20 min with frequencies of 100-200 Hz. The treatment outcome was evaluated using Global Rating of Change (GRC) scales. In the TMD group, VAS values significantly decreased after TENS. Although there was significant increase in the maximum mouth opening after TENS for only TMD group, the maximum bite force of both groups was significantly greater after TENS. According to GRC scales, one patient with TMD-related muscle pain expressed negative feelings after TENS. Conclusively, TENS treatment might quickly relieve pain in masticatory muscles and improve masticatory functions in patients with TMD-related muscle pain. (Link to Publication Site) ● Publication site (DOI): 10.3390/jcm9103330 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33081336 ● Search Scopus @ Elsevier (PMID): 33081336 ● Search Scopus @ Elsevier (DOI): 10.3390/jcm9103330 (DOI: 10.3390/jcm9103330, PubMed: 33081336)

Proceeding of International Conference:

1.	Kaoru Yoshinaga, Akihiro Yasue, Seiichi Oyadomari and Eiji Tanaka : In vivo elucidation of the effect on the number of teeth caused by double mutant of WNT10A and WNT10B., 9th IOC, Yokohama, Oct. 2020.

Proceeding of Domestic Conference:

1.	Kazuhide Mineda, Kaoru Yoshinaga, Keiichiro Watanabe, Hiroyuki Yamasaki, MIMA Shunsuke, Yoshiro Abe, Eiji Tanaka and Ichiro Hashimoto : ファーラー法による口蓋形成の術直前後と3か月後のにおける硬口蓋の形態評価, 第41回日本頭蓋顎顔面外科学会学術集会, Nov. 2023.
2.	Kaoru Yoshinaga, Akihiro Yasue and Eiji Tanaka : Wnt10aおよびWnt10bのダブル変異が歯の発生に及ぼす影響, 第82回日本矯正歯科学会学術大会抄録集, 156, Nov. 2023.
3.	KINJO Soichiro, 塩屋園玲子, Kaoru Yoshinaga, Emiko Nakaue, Keiichiro Watanabe, Masahiro Hiasa and Eiji Tanaka : 上顎骨前方部延長術を行った口唇口蓋裂患者2症例の術後評価, The Journal of Chu-Shikoku Orthodontic Society, Vol.35, No.1, 114-115, Aug. 2023. (Keyword) 顎の奇形(外科的療法) / 歯科矯正治療 / statistics / 病院歯科診療部門 / 顎矯正手術 / ヒト; 男; 女; 歯学
4.	Keiichiro Watanabe, Kaoru Yoshinaga, KIMU Suha, HANAWA Shigeki, TANAKA Mariko, Hiroyuki Yamasaki, Kazuhide Mineda, Shinya Horiuchi, Ichiro Hashimoto and Eiji Tanaka : 中間顎誘導型NAMの早期装着により,短期間で中間顎の整位を行った両側性唇顎口蓋裂の3, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 133, May 2023. (Keyword) 唇顎口蓋裂(治療) / 術前顎矯正治療 / statistics / ヒト; 新生児; 男; 女; 歯学
5.	WADA Ryohei, Keiichiro Watanabe, Kaoru Yoshinaga, KIMU Suha, HANAWA Shigeki, TANAKA Mariko, Yuki Sakamoto, Aki Shimada, Eiji Kondou, Takamasa Kitamura, Hiroyuki Yamasaki, Kazuhide Mineda, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における過去10年間の口唇裂・口蓋裂患者に関する臨床統計調査, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 200, May 2023. (Keyword) 口蓋裂 / statistics / 大学病院 / ヒト; 男; 女; 歯学
6.	Eiji Kondou, Yuki Sakamoto, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, 山崎裕行, Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討, 第47回日本口蓋裂学会, May 2023.
7.	坂本幸, Eiji Kondou, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, 山崎裕行, Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の新生児聴覚スクリーニング結果と滲出性中耳炎罹患率, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 153, Apr. 2023. (Keyword) 口蓋裂(合併症) 新生児スクリーニング中耳炎-滲出性(診断,合併症) 発生率大学病院聴覚検査ヒト乳児(1∼23ヶ月) 幼児(2∼5) 男女歯学
8.	Eiji Kondou, 坂本幸, Aki Shimada, Kaoru Yoshinaga, Takamasa Kitamura, 山崎裕行, Kazuhide Mineda, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口蓋裂児の滲出性中耳炎と鼓膜チューブ留置術の検討, Journal fo Japanese Cleft Palate Association, Vol.48, No.2, 154, Apr. 2023. (Keyword) 口蓋裂(合併症) 中耳炎-滲出性(外科的療法,合併症) *中耳換気大学病院結果再現性ヒト乳児(1∼23ヶ月) 幼児(2∼5) 小児(6∼12) 青年期(13∼18) 男女歯学
9.	Akihiko Iwasa, Yoshiki Higa, Emiko Nakaue, Kaoru Yoshinaga, Sou Shimizu, Yuta Matsuki, Kotaro Tanimoto, Keiichiro Watanabe, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka : 特発性下顎頭吸収を呈する矯正患者の下顎頭の形態学的特徴, 第81回日本矯正歯科学会学術大会, Oct. 2022.
10.	Emiko Nakaue, Keiichiro Watanabe, Hirofumi Tenshin, Kaoru Yoshinaga, Yuta Matsuki, Masahiro Hiasa, Shinya Horiuchi and Eiji Tanaka : Identification of key determinant for predicting feasible mandibular molars distalization, The Journal of Chu-Shikoku Orthodontic Society, Jul. 2022.
11.	KIMU Suha, Keiichiro Watanabe, Kaoru Yoshinaga, Hirofumi Tenshin, Emiko Nakaue, Yoshiki Higa, 坂本幸, 近藤英司, Aki Shimada, Kazuhide Mineda, Soushi Ishida, Aya Miyazaki, Takamasa Kitamura, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : 徳島大学病院における口唇口蓋裂センター設立前後での患者動向の変化金秀河(徳島大学大学院口腔科学教育部口腔顎顔面矯正学分野), 渡邉佳一郎, 吉永薫, 天眞寛文, 中上絵美子, 比嘉佳基, 坂本幸, 近藤英司, 島田亜紀, 峯田一秀, 石田創士, 宮嵜彩, 北村尚正, 日浅雅博, 堀内信也, 岩崎智憲, 橋本一郎, 田中栄二日本口蓋裂学会雑誌(0386-5185)47巻2号 Page135(2022.04), Journal fo Japanese Cleft Palate Association, Vol.47, No.2, 135, May 2022.
12.	Keiichiro Watanabe, Hirofumi Tenshin, Kaoru Yoshinaga, Emiko Nakaue, 坂本幸, Eiji Kondou, Aki Shimada, Kazuhide Mineda, Soushi Ishida, Masahiro Hiasa, Shinya Horiuchi, Tomonori Iwasaki, Ichiro Hashimoto and Eiji Tanaka : Pre-epiglottic baton plateによる保存的治療で重度気道閉塞の改善がみられたPierre Robin Sequenceの1例, Journal fo Japanese Cleft Palate Association, Vol.47, No.2, 116, Apr. 2022. (Keyword) Pierre Robin症候群(合併症) 気道閉塞(合併症,診断,予後) 呼吸障害(病因,予後) *保存的療法哺乳障害(病因,予後) ヒト新生児男歯学
13.	Keiichiro Watanabe, Hirofumi Tenshin, Kazuhide Mineda, Soushi Ishida, Kaoru Yoshinaga, Emiko Nakaue, Yoshiki Higa, Aya Miyazaki, Takamasa Kitamura, 坂本幸, Eiji Kondou, Aki Shimada, Masahiro Hiasa, Shinya Horiuchi, Ichiro Hashimoto and Eiji Tanaka : 当院における口腔内スキャナーを活用した哺乳床早期装着のための取り組み, Journal fo Japanese Cleft Palate Association, Vol.46, No.2, 123, Apr. 2021. (Keyword) 口蓋裂口唇裂歯科用機器母乳栄養ヒト乳児(1∼23ヶ月) 歯学
14.	Kaoru Yoshinaga, 塩屋園玲子, Ayami Itoh, Yuta Matsuki, Kotaro Tanimoto, Keiichiro Watanabe and Eiji Tanaka : ソトス症候群に起因する交叉咬合を伴う骨格性下顎前突, 第63回中・四国矯正歯科学会大会, Jul. 2020.