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Tokushima UniversityInstitute of Advanced Medical Sciences基幹研究部門 (Files for researchmap) [PDF manual] [Auto-propagate to researchmap]

Research

Field of Study

Biophysics

Subject of Study

Unraveling molecular mechanism of cellular homeostasis

Book / Paper

Academic Paper (Judged Full Paper):

1. Saori Yoshimura, Ryuki Shimada, Koji Kikuchi, Soichiro Kawagoe, Hironori Abe, Sakie Iisaka, Sayoko Fujimura, Kei-Ichiro Yasunaga, Shingo Usuki, Naoki Tani, Takashi Ohba, Eiji Kondoh, Tomohide Saio, Kimi Araki and Kei-Ichiro Ishiguro :
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions.,
Nature Communications, Vol.15, No.1, 3330, 2024.
(DOI: 10.1038/s41467-024-47601-0,   PubMed: 38684656)
2. Takahiro Muraoka, Masaki Okumura and Tomohide Saio :
Enzymatic and synthetic regulation of polypeptide folding.,
Chemical Science, Vol.15, No.7, 2282-2299, 2024.
(DOI: 10.1039/d3sc05781j,   PubMed: 38362427)
3. Honoka Kawamukai, Shumpei Takishita, Kazumi Shimizu, Daisuke Kohda, Koichiro Ishimori and Tomohide Saio :
Conformational Distribution of a Multidomain Protein Measured by Single-Pair Small-Angle X-ray Scattering.,
The Journal of Physical Chemistry Letters, Vol.15, No.3, 744-750, 2024.
(DOI: 10.1021/acs.jpclett.3c02600,   PubMed: 38221741,   Elsevier: Scopus)
4. Sachiho Taniguchi, Yuji Ono, Yukako Doi, Shogo Taniguchi, Yuta Matsuura, Ayuka Iwasaki, Noriaki Hirata, Ryosuke Fukuda, Keitaro Inoue, Miho Yamaguchi, Anju Tashiro, Daichi Egami, Shunsuke Aoki, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Hiroyuki Kumeta, Tomohide Saio and Tsukasa Okiyoneda :
Identification of α-Tocopherol succinate as an RFFL-substrate interaction inhibitor inducing peripheral CFTR stabilization and apoptosis,
Biochemical Pharmacology, Vol.215, 115730, 2023.
(DOI: 10.1016/j.bcp.2023.115730,   PubMed: 37543348,   Elsevier: Scopus)
5. Soichiro Kawagoe, Munehiro Kumashiro, Takuya Mabuchi, Hiroyuki Kumeta, Koichiro Ishimori and Tomohide Saio :
Heat-Induced Conformational Transition Mechanism of Heat Shock Factor 1 Investigated by Tryptophan Probe.,
Biochemistry, Vol.61, No.24, 2897-2908, 2022.
(DOI: 10.1021/acs.biochem.2c00492,   PubMed: 36485006)
6. Masato Miyake, Mitsuaki Sobajima, Kiyoe Kurahashi, Akira Shigenaga, Masaya Denda, Akira Otaka, Tomohide Saio, Naoki Sakane, Hidetaka Kosako and Seiichi Oyadomari :
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells.,
Cell Chemical Biology, Vol.29, No.6, 996-1009.e9, 2022.
(Tokushima University Institutional Repository: 116761,   DOI: 10.1016/j.chembiol.2022.01.002,   PubMed: 35143772)
7. Motonori Matsusaki, Rina Okada, Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Mai Watabe, Hiroshi Yamaguchi, Tomohide Saio, Young-Ho Lee, Kenji Inaba and Masaki Okumura :
Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding,
Biology, Vol.10, No.11, 1112, 2021.
(Tokushima University Institutional Repository: 116440,   DOI: 10.3390/biology10111112,   CiNii: 1050571547625565952,   Elsevier: Scopus)
8. Haojie Zhu, Motonori Matsusaki, Taiga Sugawara, Koichiro Ishimori and Tomohide Saio :
Zinc-Dependent Oligomerization of Thermus thermophilus Trigger Factor Chaperone,
Biology, Vol.10, No.11, 1106, 2021.
(Tokushima University Institutional Repository: 117166,   DOI: 10.3390/biology10111106,   PubMed: 34827099)
9. Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi, Riko Nagata, Masaya Matsubayashi, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Naritaka Morikawa, Naohiko Iguchi, Takao Kiriyama, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Takashi Oda, Noriyuki Kodera, Sachiko Toma-Fukai, Mamoru Sato, Hideki Taguchi, Shushi Nagamori, Osami Shoji, Koichiro Ishimori, Hiroyoshi Matsumura, Kazuma Sugie, Tomohide Saio, Takuya Yoshizawa and Eiichiro Mori :
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers,
Nature Communications, Vol.12, No.1, 5301, 2021.
(Tokushima University Institutional Repository: 117572,   DOI: 10.1038/s41467-021-25560-0,   PubMed: 34489423,   Elsevier: Scopus)
10. Hiroshi Nakagawa, Tomohide Saio, Michihiro Nagao, Rintaro Inoue, Masaaki Sugiyama, Satoshi Ajito, Taiki Tominaga and Yukinobu Kawakita :
Conformational dynamics of a multidomain protein by neutron scattering and computational analysis.,
Biophysical Journal, Vol.120, No.16, 3341-3354, 2021.
(DOI: 10.1016/j.bpj.2021.07.001,   PubMed: 34242590)
11. Tomohide Saio, Soya Hiramatsu, Mizue Asada, Hiroshi Nakagawa, Kazumi Shimizu, Hiroyuki Kumeta, Toshikazu Nakamura and Koichiro Ishimori :
electron paramagnetic resonance.,
Biophysical Journal, Vol.120, No.15, 2943-2951, 2021.
(DOI: 10.1016/j.bpj.2021.06.033,   PubMed: 34242587)
12. Masahiro Mimura, Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio, Kentaro Shiraki and Ryoji Kurita :
Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation.,
Journal of the American Chemical Society, Vol.143, No.26, 9849-9857, 2021.
(DOI: 10.1021/jacs.1c03447,   PubMed: 34152774)
13. Masaki Okumura, Shingo Kanemura, Motonori Matsusaki, Misaki Kinoshita, Tomohide Saio, Dai Ito, Chihiro Hirayama, Hiroyuki Kumeta, Mai Watabe, Yuta Amagai, Young-Ho Lee, Shuji Akiyama and Kenji Inaba :
A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization.,
Structure, Vol.29, No.12, 1357-1370.E6, 2021.
(DOI: 10.1016/j.str.2021.03.016,   PubMed: 33857433)
14. Aya Okuda, Rintaro Inoue, Ken Morishima, Tomohide Saio, Yasuhiro Yunoki, Maho Yagi-Utsumi, Hirokazu Yagi, Masahiro Shimizu, Nobuhiro Sato, Reiko Urade, Koichi Kato and Masaaki Sugiyama :
Deuteration Aiming for Neutron Scattering.,
Biophysics and Physicobiology, Vol.18, 16-27, 2021.
(DOI: 10.2142/biophysico.bppb-v18.003,   PubMed: 33954079)
15. Kamran Rizzolo, Hsiung Angela Yeou Yu, Adedeji Ologbenla, Rang Sa Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Wen Yi Zhang, Mona Teng, Marta Haniszewski, Noha Miah, Sadhna Phanse, Zoran Minic, Sukyeong Lee, Diaz Julio Caballero, Mohan Babu, F Francis T Tsai, Tomohide Saio and A Walid Houry :
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex.,
Nature Communications, Vol.12, No.1, 2021.
(Tokushima University Institutional Repository: 116608,   DOI: 10.1038/s41467-020-20553-x,   PubMed: 33436616)
16. Rintaro Inoue, Takashi Oda, Hiroshi Nakagawa, Taiki Tominaga, Tomohide Saio, Yukinobu Kawakita, Masahiro Shimizu, Aya Okuda, Ken Morishima, Nobuhiro Sato, Reiko Urade, Mamoru Sato and Masaaki Sugiyama :
Dynamics of proteins with different molecular structures under solution condition.,
Scientific Reports, Vol.10, No.1, 2020.
(Tokushima University Institutional Repository: 116638,   DOI: 10.1038/s41598-020-78311-4,   PubMed: 33303822)
17. Yuya Taguchi, Tomohide Saio and Daisuke Kohda :
Distance Distribution between Two Iodine Atoms Derived from Small-Angle X-ray Scattering Interferometry for Analyzing a Conformational Ensemble of Heavy Atom-Labeled Small Molecules.,
The Journal of Physical Chemistry Letters, Vol.11, No.14, 5451-5456, 2020.
(DOI: 10.1021/acs.jpclett.0c01107,   PubMed: 32558579)
18. Masaki Okumura, Kentaro Noi, Shingo Kanemura, Misaki Kinoshita, Tomohide Saio, Yuichi Inoue, Takaaki Hikima, Shuji Akiyama, Teru Ogura and Kenji Inaba :
Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding.,
Nature Chemical Biology, Vol.15, No.5, 499-509, 2019.
(DOI: 10.1038/s41589-019-0268-8,   PubMed: 30992562)
19. Soichiro Kawagoe, Hiroshi Nakagawa, Hiroyuki Kumeta, Koichiro Ishimori and Tomohide Saio :
Structural insight into proline cis/ trans isomerization of unfolded proteins catalyzed by the trigger factor chaperone,
The Journal of Biological Chemistry, Vol.293, No.39, 15095-15106, 2018.
(DOI: 10.1074/jbc.RA118.003579,   PubMed: 30093407)
20. Tomohide Saio, Soichiro Kawagoe, Koichiro Ishimori and G Charalampos Kalodimos :
Oligomerization of a molecular chaperone modulates its activity.,
eLife, Vol.7, e35731, 2018.
(DOI: 10.7554/eLife.35731,   PubMed: 29714686,   Elsevier: Scopus)
21. Wataru Sato, Takeshi Uchida, Tomohide Saio and Koichiro Ishimori :
Polyethylene glycol promotes autoxidation of cytochrome c.,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1862, No.6, 1339-1349, 2018.
(DOI: 10.1016/j.bbagen.2018.03.010,   PubMed: 29540304)

Academic Paper (Unrefereed Paper):

1. Takahiro Muraoka, Tomohide Saio and Masaki Okumura :
Biophysical elucidation of neural network and chemical regeneration of neural tissue.,
Biophysics and Physicobiology, Vol.19, 2022.
(Tokushima University Institutional Repository: 118277,   DOI: 10.2142/biophysico.bppb-v19.0024,   PubMed: 36071879)

Review, Commentary:

1. Soichiro Kawagoe, Koichiro Ishimori and Tomohide Saio :
Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding.,
International Journal of Molecular Sciences, Vol.23, No.5, Feb. 2022.
(Tokushima University Institutional Repository: 118276,   DOI: 10.3390/ijms23052485,   PubMed: 35269628,   Elsevier: Scopus)
2. Soichiro Kawagoe, Mori Eiichiro and Tomohide Saio :
Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones,
Thermal Medicine, Vol.37, No.2, 31-44, Aug. 2021.
(DOI: 10.3191/thermalmed.37.31,   CiNii: 1390570408616681984)
3. Takuya Yoshizawa, Ryu-Suke Nozawa, Z Tony Jia, Tomohide Saio and Eiichiro Mori :
Biological phase separation: cell biology meets biophysics.,
Biophysical Reviews, Vol.12, No.2, 519-539, Mar. 2020.
(DOI: 10.1007/s12551-020-00680-x,   PubMed: 32189162)
4. Masaaki Sugiyama, Rintaro Inoue, Hiroshi Nakagawa and Tomohide Saio :
Solution Neutron Scattering,
hamon, Vol.30, No.1, 16-25, 2020.
(DOI: 10.5611/hamon.30.1_16,   CiNii: 1390851165527349120)
5. 小田 隆 and Tomohide Saio :
検出技術 : 天然変性タンパク質の構造生物学 (特集 相分離生物学 : 相分離メガネのススメ),
Seibutsu-kogaku Kaishi, Vol.98, No.5, 232-235, 2020.
(CiNii: 1520853833284793216)
6. Tomohide Saio and Koichiro Ishimori :
Accelerating structural life science by paramagnetic lanthanide probe methods.,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1864, No.2, 129332, Mar. 2019.
(DOI: 10.1016/j.bbagen.2019.03.018,   PubMed: 30928492)

Proceeding of International Conference:

1. Tomohide Saio :
Depicting chaperone-mediated protein folding at residue-resolution,
International Symposium on Multifaceted Protein Dynamics, Fukuoka, Sep. 2024.
2. Tomohide Saio :
Mechanistic insight into concerted action of a chaperone complex.,
The 8th International Symposium on Drug Discovery and Design by NMR, Yokohama, Aug. 2024.
3. Tomohide Saio :
Visualizing conformational changes of a multidomain protein enzyme using paramagnetic probes,
International Society of Magnetic Resonance (ISMAR) 2023, Brisbane, Aug. 2024.
4. Munehiro Kumashiro, Welegedara Adarshi, Otting Gottfried and Tomohide Saio :
Real-Time, Site-Specific Observation of Chaperone-Mediated Protein Folding using Noncanonical Amino Acid Labeling,
International Union for Pure and Applied Biophysics (IUPAB) 2024, Kyoto, Jun. 2024.
5. Tomohide Saio :
Mechanistic insight into concerted action of a chaperone complex,
The 7th bilateralTaiwan-Japan NMR Symposium, Higashihiroshima, Feb. 2024.
6. Tomohide Saio :
Integrative Structural Study on a Multidomain Protein Enzyme Utilizing Paramagnetic Lanthanide Ion,
Asia-Pacific Nuclear Magnetic Resonance (APNMR) 2023, Taipei, Sep. 2023.
7. Tomohide Saio :
Conformational distribution of a multi-domain protein enzyme investigated by paramagnetic NMR and ESR,
3rd India-Japan NMR WORK SHOP, Online, Feb. 2023.
8. Tomohide Saio :
NMR investigation of the regulators in protein folding and assembly,
ZOOMinar on Molecular Bases of Proteinopathies, Online, Feb. 2023.
9. Tomohide Saio :
Structural and kinetic views of regulators for protein folding and assembly,
International Symposium: Protein Folding, Aggregation, Misfolding Disease, and Disease Crosstalk, Online, Sep. 2022.
10. Tomohide Saio :
Conformational Variation of a Multi-Domain Protein Enzyme Investigated by Paramagnetic Lanthanide Probe,
ISMAR-APNMR2021, Aug. 2021.
11. Tomohide Saio, Hiroshi Nakagawa, Soya Hiramatsu, Mizue Asada, Honoka Kawamukai, Toshikazu Nakamura and Koichiro Ishimori :
Application of a lanthanide tag for evaluation of conformational states of a multidomain protein,
IUCr 2021 - XXV General Assembly and Congress of the International Union of Crystallography, Aug. 2021.
12. Tomohide Saio :
Mechanistic insights into a molecular chaperone in protein folding and degradation,
2021 virtual Cold Spring Harbor Asia Conference, Mar. 2021.
13. Tomohide Saio :
NMR investigation of molecular chaperones manipulating protein folding,
Pacifichem 2021, 2021.
14. Tomohide Saio :
Structural and kinetic insights into a molecular chaperone for protein folding, translocation, and degradation,
Pacifichem 2021, 2021.
15. Kawamukai Honoka, Ishimori Koichiro and Tomohide Saio :
ALS-associated factor PRn inhibit the function of KapB2,
The 16th International Symposium of the Institute Network for Biomedical Sciences & KEY FORUM 2021 International Symposium, 2021.
16. Tomohide Saio :
Mechanistic insight into chaperone-mediated protein homeostasis,
The 16th International Symposium of the Institute Network for Biomedical Sciences & KEY FORUM 2021 International Symposium, 2021.
17. Tomohide Saio :
On and off between molecular chaperones and clients: Appropriate distance and timing for protein folding,
21st Hokudai-RIES International Symposium, Dec. 2020.

Proceeding of Domestic Conference:

1. 金村 進吾, 橋本 里菜, Motonori Matsusaki, 馬渕 拓哉, 渡部 マイ, Tomohide Saio, 高山 和雄, 李 映昊 and 奥村 正樹 :
Understanding the mechanism by which extracellular oxidoreductases inhibit viral infection,
第24回日本蛋白質科学会年会, Jun. 2024.
2. 渡部 マイ, 金村 進吾, 鈴木 琴乃, 坂 和範, Motonori Matsusaki, 稲葉 謙次, 中林 孝和, 李 映昊, Tomohide Saio and 奥村 正樹 :
Effects of ROS/RNS on the droplet formation of the ER-resident enzyme,
第24回日本蛋白質科学会年会, Jun. 2024.
3. 武井 梓穂, 宇賀 神魁, Soichiro Kawagoe, Tomohide Saio, 松田 正, 前仲 勝実, 姚 閔 and 尾瀬 農之 :
乳がん特異的キナーゼとアダプター蛋白質が形成する分子集合と酵素活性の相関を検証する,
第24回日本蛋白質科学会年会, Jun. 2024.
4. 森 圭太, Tomohide Saio and 村岡 貴博 :
Metal-binding Disulfide Compounds for Inhibition of Protein Aggregation and Promotion of Oxidative Folding,
第24回日本蛋白質科学会年会, Jun. 2024.
5. 熊代 宗弘, 久米田 博之, Welegedara Adarshi, Qianzhu Haocheng, Abdelkader Elwy, Huber Thomas, Otting Gottfried and Tomohide Saio :
Residue-Level Characterization of Chaperone-Mediated Protein Folding using NMR Relaxation Dispersion and Unnatural Amino Acid Fluorescence,
第24回日本蛋白質科学会年会, Jun. 2024.
6. Motonori Matsusaki and Tomohide Saio :
PAGEを基盤とした抗原抗体反応における会合状態分布の解析,
第24回日本蛋白質科学会年会, Jun. 2024.
7. Soichiro Kawagoe, 久米田 博之 and Tomohide Saio :
Heat shock factor-1のストレス応答性液-液相分離の構造基盤,
第24回日本蛋白質科学会年会, Jun. 2024.
8. 熊代 宗弘 and Tomohide Saio :
Mechanism of Chaperone-Assisted Protein Folding: Insight from a Variety of Time-Resolved Biophysical Methods,
第15回日本生物物理学会 中国四国支部大会, May 2024.
9. Tomohide Saio :
動的タンパク質複合体の 構造・キネティクスの理解,
日本薬学会第144年会, Mar. 2024.
10. Motonori Matsusaki, Takeshi Yokoyama, Atsushi Tsugita, Shingo Kanemura, Michiko Tajiri, Satoko Akashi, Kentaro Noi, Tomohide Saio, Kenji Inaba and Masaki Okumura :
小胞体ストレスセンサーIRE1による活性酸素種の直接的感知と分子シャペロンによるその制御,
日本農芸化学会2024年度大会, Mar. 2024.
11. 鈴木 洸希, 野尻 涼矢, Tomohide Saio and 村岡 貴博 :
速度論の観点から理解する シャペロンによるフォールディング制御メカニズム,
日本化学会 第104春季年会, Mar. 2024.
12. Tomohide Saio :
相分離シャペロンの機能阻害メカニズム,
第46回 日本分子生物学会年会, Dec. 2023.
13. Soichiro Kawagoe, 馬渕 拓哉, 久米田 博之, Motonori Matsusaki, 熊代 宗弘, 石森 浩一郎 and Tomohide Saio :
Molecular mechanisms of multiple interactions regulating stress sensor assembly,
第61回日本生物物理学会年会, Nov. 2023.
14. 服部 良一, 熊代 宗弘, 高 麗王, 姜 泰成, 久米田 博之, Motonori Matsusaki and Tomohide Saio :
神経変性疾患関連変異によるプロリン異性化酵素PPIAのダイナミクス変調,
第 62回 NMR討論会, Nov. 2023.
15. 朱 浩傑, Soichiro Kawagoe, 久米田 博之, 石森 浩一郎 and Tomohide Saio :
タンパク質アンフォールディングを担う シャペロン複合体の構造解析,
第 62回 NMR討論会, Nov. 2023.
16. Tomohide Saio :
液-液相分離制御と神経変性疾患の動的構造基盤,
第96回 日本生化学会大会, Nov. 2023.
17. Motonori Matsusaki, Takeshi Yokoyama, Atsushi Tsugita, Shingo Kanemura, Michiko Tajiri, Satoko Akashi, Kentaro Noi, Tomohide Saio, Kenji Inaba and Masaki Okumura :
小胞体ストレスセンサーIRE1 によるストレス感知と越膜シグナル変換の分子機構,
第96回日本生化学会, Nov. 2023.
18. Motonori Matsusaki, Takeshi Yokoyama, Atsushi Tsugita, Shingo Kanemura, Michiko Tajiri, Satoko Akashi, Kentaro Noi, Tomohide Saio, Kenji Inaba and Masaki Okumura :
小胞体ストレスセンサーIRE1の多量体形成ポテンシャルとストレス感知,
第23回日本蛋白質科学会年会, Jul. 2023.
19. Tomohide Saio, 川向 ほの香, 加藤 胡都菜, Motonori Matsusaki, 久米田 博之 and 石森 浩一郎 :
Pro-Argポリジペプチドの毒性発現メカニズムの解明,
第23回蛋白質科学会, Vol.-, No.-, -, Jul. 2023.
20. Tomohide Saio :
多様な結合様式を介した環境応答性相分離と相転移,
第23回蛋白質科学会年会, Vol.-, No.-, -, Jul. 2023.
21. Soichiro Kawagoe, 馬渕 拓哉, 久米田 博之, 熊代 宗弘, 石森 浩一郎 and Tomohide Saio :
局所構造形成と連動したheat shock factor-1の会合状態変化,
第23回日本蛋白質科学会年会, Jul. 2023.
22. Tomohide Saio :
ランタノイドタグを用いた蛋白質の動的構造解析,
日本化学会第103春季年会(2023), Mar. 2023.
23. Tomohide Saio :
常磁性プローブを用いたマルチドメインタンパク質の構造解析,
蛋白研セミナー 基礎から学ぶ最新NMR解析法 第6回ワークショップ 統合型構造生物学研究, Mar. 2023.
24. Tomohide Saio :
Structural insight into regulation and dysregulation of protein assembly and folding,
The 1st IMEG Meeting of The Research Center for High Depth Omics, Jan. 2023.
25. Tomohide Saio :
シャペロンから解き明かすタンパク質フォールディングと集合の分子メカニズム,
第18回Organelle zone seminar, Dec. 2022.
26. Tomohide Saio :
相分離制御と制御破綻の分子メカニズム,
2022 年度 日本分光学会NMR分光部会 集中講義, Oct. 2022.
27. Tomohide Saio :
分子から理解する相分離制御と破綻,
第 74 回 日本細胞生物学会年会, Jun. 2022.
28. Soichiro Kawagoe, Motonori Matsusaki, 石森 浩一郎 and Tomohide Saio :
高次多量体形成が駆動するheat shock factor-1液滴の酸化的相転移,
第 22 回日本蛋白質科学会年会, Jun. 2022.
29. KAWAMUKAI Honoka, 石森 浩一郎 and Tomohide Saio :
核輸送因子Kapβ2のFUSに対する液-液相分離制御におけるPro-Argポリジペプチドによる阻害機構の解明,
第 22 回日本蛋白質科学会年会, Jun. 2022.
30. Tomohide Saio :
シャペロンにおけるキネティクス-活性相関,
第 22 回日本蛋白質科学会年会, Jun. 2022.
31. Tomohide Saio :
シャペロンによるタンパク質集合とフォールディングの制御機構,
千里ライフサイエンスセミナーV1 相分離がもたらす医療・創薬の新展開, May 2022.
32. Tomohide Saio :
NMRを中核とした統合的解析でタンパク質の動きを捉える,
蛋白研フロンティアセミナー, Apr. 2022.
33. Tomohide Saio :
タンパク質液滴の形成・制御・破綻の分子メカニズム,
日本化学会第102春季年会, Mar. 2022.
34. Motonori Matsusaki, Takeshi Yokoyama, Atsushi Tsugita, Shingo Kanemura, Michiko Tajiri, Satoko Akashi, Tomohide Saio, Kenji Inaba and Masaki Okumura :
小胞体ストレスセンサーの会合状態分布を介した応答制御機構の研究,
日本農芸化学会2022年度大会, Mar. 2022.
35. 太田 帆香, Soichiroh Kawagoe, Motonori Matsusaki, 久米田 博之, 石森 浩一郎 and Tomohide Saio :
新規光応答性シャペロンの創製とそれを利用した液-液相分離の制御,
2021年度 生物物理学会 北海道支部-東北支部合同例会, Mar. 2022.
36. 岡田 莉奈, 金村 進吾, 黒井 邦巧, Motonori Matsusaki, Tomohide Saio, 山口 宏, 伊藤 大, 李 映昊, 中林 孝和, 稲葉 謙次 and 奥村 正樹 :
酸化還元制御によるヒトガレクチン1の構造機能調節の理解(Understanding the role of redox-regulated galectin-1 function),
第44回 日本分子生物学会年会, Dec. 2021.
37. Soichiroh Kawagoe, Motonori Matsusaki, 石森 浩一郎 and Tomohide Saio :
ストレス応答を制御する転写因子Heat shock factor1の酸化還元依存的な相転移,
第44回 日本分子生物学会年会, Dec. 2021.
38. Tomohide Saio :
多量体形成を介したシャペロンの機能制御,
第44回 日本分子生物学会年会, Dec. 2021.
39. Tomohide Saio :
速度論の観点から理解するシャペロンによるフォールディング制御メカニズム,
学術変革B「遅延制御超分子化学」 キックオフシンポジウム, Nov. 2021.
40. Tomohide Saio :
Large-scale conformational distribution of a multi-domain protein enzyme investigated by NMR and EPR,
第59回日本生物物理学会年会, Nov. 2021.
41. Tomohide Saio :
常磁性金属と分子シャペロン,
2020年度 日本分光学会NMR分光部会 集中講義, Oct. 2020.
42. Tomohide Saio and 石森 浩一郎 :
Exploiting paramagnetic metal ions for protein structural study in solution,
The 58th Annual Meeting of the BSJ, Sep. 2020.
43. Tomohide Saio :
Understanding molecular mechanism of chaperone-mediated proteostasis in the cell,
第93回日本生化学会大会, Sep. 2020.

Et cetera, Workshop:

1. Tomohide Saio :
シャペロンによるフォールディングと分子集合の 制御メカニズム,
日本薬学会 構造活性相関部会 構造活性フォーラム2023, Aug. 2024.
2. Tomohide Saio :
生命を駆動する動的分子認識の理解,
徳島大学医光融合研究シンポジウム, Mar. 2024.
3. Tomohide Saio :
生命を駆動する動的相互作用の機序解明,
奈良県立医科大学 V-iCliniX講座 最終成果報告会, Feb. 2024.
4. Tomohide Saio :
シャペロンから解き明かすタンパク質フォールディングと 集合の制御メカニズム,
R022 量子構造生物学委員会 第 11 回研究会, Nov. 2023.
5. Tomohide Saio :
生命を駆動する弱い相互作用の探究,
第18回 オールスター最先端セミナー, Nov. 2023.
6. Tomohide Saio :
生体分子の弱い相互作用をNMRで可視化する,
東京大学 「産学連携研究会」, Sep. 2023.
7. Tomohide Saio :
シャペロンによるフォールディングとタンパク質集合の制御メカニズム,
日本薬学会構造活性相関部会 構造活性フォーラム2023, Vol.-, No.-, -, Aug. 2023.
8. Tomohide Saio :
NMR investigation of the regulators in protein folding and assembly,
International symposium on Kinetics-driven supramolecular chemistry, Vol.-, No.-, -, Jul. 2023.
9. Tomohide Saio :
シャペロンによるタンパク質集合とフォールディングの制御機構,
千里ライフサイエンスセミナー, Vol.-, No.-, -, May 2023.
10. Tomohide Saio :
NMRを中核とした統合的解析でタンパク質の動きを捉える,
蛋白研フロンティアセミナー, Vol.-, No.-, -, Apr. 2023.
11. Tomohide Saio, 宮ノ入 洋平, 中川 敦史, 八木 宏昌, 木川 隆則, 矢吹 孝, 松田 夏子, 竹内 恒, 小橋川 敬博, 坂倉 正義 and 幸福 裕 :
蛋白研セミナー 基礎から学ぶ最新 NMR 解析法 – NMR試料の調製,
次世代NMRワーキンググループ, Dec. 2021.
12. Tomohide Saio :
シャペロンによる分子集合制御,
第5回LLPS研究会, Sep. 2021.

Patent:

1. 奥村 正樹, 稲葉 謙次, Motonori Matsusaki, 金村 進吾 and Tomohide Saio : 液滴およびその製造方法, 2022-502960 (Jun. 2021), (Dec. 2022), 7194403.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Molecular dissection of plant specialized metabolism machineries (Project/Area Number: 23H05470 )
  • Stratification of Protein Aggregation States based on Pattern Recognition for Screening Factors Controlling Phase Separation (Project/Area Number: 23K26688 )
  • 光技術と構造生物学の融合による過渡構造解析 (Project/Area Number: 22K18361 )
  • Mechanism of chaperone activity modulation through promiscuous recognitions (Project/Area Number: 23K23824 )
  • Unraveling the mechanism of kinetic regulation in biomolecular folding (Project/Area Number: 21H05094 )
  • Organization of kinetics-driven supramolecular chemistry (Project/Area Number: 21H05093 )
  • Structural basis for recognition and regulation of protein folding intermediate by molecular chaperones in the endoplasmic reticulum (Project/Area Number: 20KK0156 )
  • Regulatory mechanism of biological phase separation (Project/Area Number: 20H03199 )
  • 相分離を介したシグナル伝達制御の構造基盤 (Project/Area Number: 19H04945 )
  • Structural basis for chaperone network mediated by semi-specific recognitions (Project/Area Number: 19K06504 )
  • Neutron Structural Biology for New Generation (Project/Area Number: 18H05229 )
  • NMRを主体としたタンパク質構造推移解析のための複合手法の開発と応用 (Project/Area Number: 17H05867 )
  • 分子シャペロンの基質選択と活性発現における動的構造基盤 (Project/Area Number: 17H05657 )
  • Dynamic Structural Characterization of Electron Transfer Complex in Respiratory Chain of Mitochondria and Its Electron Transfer Regulation Mechanism (Project/Area Number: 16H04173 )
  • NMRを主体としたタンパク質構造推移解析のための複合手法の開発と応用 (Project/Area Number: 15H01624 )
  • Analysis of respiratory electron transport chain using the paramagnetic probes (Project/Area Number: 15K20829 )
  • Functional and Structural Characterization of Electron Transfer Reactions in Mitochondria Respiratory Chain Utilizing Nanodisc (Project/Area Number: 25288072 )
  • Search by Researcher Number (80740802)