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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 歯学域 ⟩ Oral Science ⟩ Clinical Dentistry ⟩ Department of Stomatognathic Function and Occlusal Reconstruction ⟩
Tokushima University ⟩ Faculty of Dentistry ⟩ Course in Dentistry ⟩ Clinical Dentistry for Oral Health and Function ⟩ Fixed Prosthodontics ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of General Dentistry ⟩ Fixed Prosthodontics ⟩ 		(Files for researchmap) [PDF manual] [Auto-propagate to researchmap]

Research

Field of Study

○ Prosthodontics

Subject of Study

○ Elucidation of the receptor mechanism of masticatory muscle pain in muscle pain model rats and formation of a basis for the development of therapeutic methods. (咬筋痛, 線維筋痛症, グリア細胞, inflammatory cytokine, ミノサイクリン, レセルピン)

Book / Paper

Academic Paper (Judged Full Paper):

1. Yoshitaka Suzuki, Kazuo Okura, Toyoko Tajima, Junhel Dalanon, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka :
Essence of diagnosis and management of sleep bruxism,
Journal of Oral Health and Biosciences, Vol.36, No.2, 22-29, 2024.
(Tokushima University Institutional Repository: 119296,   DOI: 10.20738/johb.36.2_22,   CiNii: 1390862555421219200)
2. S Raman, Daisuke Ikutame, Kazuo Okura and Yoshizo Matsuka :
Targeted therapy for orofacial pain: A novel perspective for precision medicine,
Journal of Personalized Medicine, Vol.13, No.3, 565, 2023.
(Tokushima University Institutional Repository: 118082,   DOI: 10.3390/jpm13030565,   PubMed: 36983746)
3. S Raman, Arief Waskitho, R Raju, Takuma Iwasa, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka :
Analgesic effect of tranilast in an animal model of neuropathic pain and its role in the regulation of tetrahydrobiopterin synthesis,
International Journal of Molecular Sciences, Vol.23, No.11, 5878, 2022.
(Tokushima University Institutional Repository: 118650,   DOI: 10.3390/ijms23115878)
4. Arief Waskitho, Yumiko Yamamoto, S Raman, Fumiya Kano, Huijiao Yan, R Raju, S Afroz, Tsuyoshi Morita, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima, Akihito Yamamoto, Otto Baba and Yoshizo Matsuka :
Peripherally Administered Botulinum Toxin Type A Localizes Bilaterally in Trigeminal Ganglia of Animal Model,
Toxins, Vol.13, No.10, 704, 2021.
(Tokushima University Institutional Repository: 116383,   DOI: 10.3390/toxins13100704)
5. Daisuke Ikutame, Kentaro Urata, Tatsuki Oto, Shintaro Fujiwara, Toshimitsu Iinuma, Ikuko Shibuta, Yoshinori Hayashi, Suzuro Hitomi, Koichi Iwata and Masamichi Shinoda :
Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity.,
International Journal of Molecular Sciences, Vol.21, No.21, 2020.
(DOI: 10.3390/ijms21217871,   PubMed: 33114176)
6. Masamichi Shinoda, Satoshi Fujita, Shiori Sugawara, Sayaka Asano, Ryo Koyama, Shintaro Fujiwara, Kumi Soma, Takaaki Tamagawa, Tomoyuki Matsui, Daisuke Ikutame, Masatoshi Ando, Ayaka Osada, Yuki Kimura, Kazutaka Kobayashi, Takamitsu Yamamoto, Kuniko Kusama-Eguchi, Masayuki Kobayashi, Yoshinori Hayashi and Koichi Iwata :
Suppression of Superficial Microglial Activation by Spinal Cord Stimulation Attenuates Neuropathic Pain Following Sciatic Nerve Injury in Rats.,
International Journal of Molecular Sciences, Vol.21, No.7, 2020.
(DOI: 10.3390/ijms21072390,   PubMed: 32235682)
7. K Urata, M Shinoda, Daisuke Ikutame, T Iinuma and K Iwata :
Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain.,
Oral Diseases, Vol.24, No.6, 1093-1100, 2018.
(DOI: 10.1111/odi.12853,   PubMed: 29505690)

Academic Paper (Unrefereed Paper):

1. Yoshizo Matsuka, 山本 由弥子, Raman Swarna, Daisuke Ikutame, Takuma Iwasa and Kazuo Okura :
Botulinum Toxin Mechanisms for Orofacial Pain,
Japanese Journal of Orofacial Pain, Vol.16, No.1, 21-24, 2024.
(DOI: 10.11264/jjop.16.21,   CiNii: 1390581401102954496)

Proceeding of International Conference:

1. Lutfi Perdana, R Raju, Jaime Fabillar, Dara Arini, S Raman, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka :
Investigating the antinociceptive mechanism of ril-10: a novel therapeutic target for orofacial pain,
Asian Academy of Orofacial Pain and Temporomandibular Disorders, Taipei, Nov. 2024.
2. Perdana P Lutfi, Masamitsu Ohshima, Daisuke Ikutame and Yoshizo Matsuka :
The potent effect of IL-10 induced β-endorphin on alleviating trigeminal neuropathic pain,
Asian Academy of Prosthodontics, Chiba, Jul. 2024.

Proceeding of Domestic Conference:

1. 谷脇 竜弥, Maki Hosoki, Masamitsu Ohshima, Kazuo Okura, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Mayu Miyagi, 伸幸 板東, OZAWA Aya, 吉原 靖智, 新開 瑞希, 柴垣 あかり, 青木 映璃, Kouhei Kamoi and Yoshizo Matsuka :
徳島大学における補綴学実習の評価と改善,
大学教育カンファレンスin徳島, Dec. 2024.
2. (名) Lutfi, Raman Swarna, (名) Jaime, (名) Dara, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka :
β-endorphin induced by rIL-10 serves as a potential target for alleviating trigeminal neuropathic pain,
The 49th Okayama Brain Research Seminar, Sep. 2024.
3. Kazuyuki Koike, Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, 吉原 靖智, 谷脇 竜弥, Masamitsu Ohshima and Yoshizo Matsuka :
掌蹠膿疱症性骨関節炎における歯科金属除去の重要性:症例報告と考察,
日本補綴学会中国四国支部学術大会, Aug. 2024.
4. Daisuke Ikutame, 谷脇 竜弥 and Yoshizo Matsuka :
咀嚼障害と筋痛を主訴とする患者へ適切な義歯を装着し症状の改善をみた症例,
Journal of the Japanese Society for the Temporomandibular Joint, Jul. 2024.
5. 谷脇 竜弥, Maki Hosoki, Mayu Miyagi, 伸幸 板東, Masamitsu Ohshima, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Aya OZAWA, 青木 映璃, 吉原 靖智, Kazuo Okura, 新開 瑞希, 柴垣 あかり and Yoshizo Matsuka :
クラウンブリッジ補綴学模型実習の改善:アンケート調査に基づく分析,
The Journal of the Japan Prosthodontic Society, Jul. 2024.
6. 横井 美有希, 安部 倉仁, 森田 晃司, 土井 一矢, Maki Hosoki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, 中川 晋輔, 秋山 謙太郎, 縄稚 久美子, 黒崎 陽子, Yoshizo Matsuka, 窪木 拓男 and 津賀 一弘 :
最後方大臼歯へのPEEKクラウンの臨床応用についての6ヶ月間の評価,
The Journal of the Japan Prosthodontic Society, Jul. 2024.
7. Putra Lutfi Perdana, Swarna Lakshmi Raman, Fabillar Jr. Jaime Moreno, Arini Sari Dara, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka :
Pain-relief mechanism of IL-10 in the trigeminal ganglia: insights into trigeminal neuropathic pain management,
Brain Science cluster minirtreat, Feb. 2024.
8. Daisuke Ikutame, Kazuo Okura and Yoshizo Matsuka :
咀嚼筋痛モデルラットを用いた咀嚼筋痛受容機構の解明,
Japanese Journal of Orofacial Pain, Nov. 2023.
9. Miho Inoue, Masamitsu Ohshima, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka :
口腔顔面痛はアロマテラピーで軽減する∼口腔顔面痛モデル動物での評価∼,
The Journal of the Japan Prosthodontic Society, May 2023.
10. Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸 板東, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, SHINKAI Mizuki and Yoshizo Matsuka :
デジタル化に対応したクラウンブリッジ補綴学実習の検討,
The Journal of the Japan Prosthodontic Society, May 2023.
11. 蓮池 真由子, Miho Inoue, RAMAN SWARNA LAKSHMI, Jaime M.Fabillar, Lutfi P.Perdana, Mayu Miyagi, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka :
口腔顔面痛モデル動物を用いた精油嗅覚刺激の疼痛抑制効果∼ベルガモット，ラベンダーの検討∼,
Shikoku Dental Research, Mar. 2023.
12. Jr.M.Fabillar Jaime, Raman Swarna, P.Perdana Lutfi, Daisuke Ikutame, Kazuo Okura, Masamitsu Ohshima and Yoshizo Matsuka :
Bilateral transport of neuronal tracer after unilateral administration,
徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
13. Miho Inoue, RAMAN SWARNA LAKSHMI, FABILLAR JR. JAIME MORENO, 蓮池 真由子, PERDANA LUTFI PUTRA, 井上 正久, Daisuke Ikutame, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka :
精油成分による口腔顔面痛モデル動物の痛み軽減とメカニズム,
徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
14. Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸 板東, C. Riquelme, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, 新開 みずき and Yoshizo Matsuka :
デジタル化が進む歯科診療の現状紹介と歯科補綴学実習における学習内容の検討,
大学教育カンファレンスin徳島, Dec. 2022.
15. Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Maki Hosoki, Daisuke Ikutame, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka :
アクティブラーニングの学修効果 ―オンライン授業と通常授業，TBL授業の比較―,
The Journal of Japanese Dental Education Association, Jul. 2022.
16. Maki Hosoki, Kazuo Okura, Miho Inoue, Yoshitaka Suzuki, Daisuke Ikutame, Susumu Abe, Fumiaki Kawano and Yoshizo Matsuka :
2021年度歯科補綴学実習の評価,
The Journal of Japanese Dental Education Association, Jul. 2022.
17. Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, Toyoko Tajima, Yasutomo Yoshihara, Aya OZAWA, SHINKAI Mizuki and Yoshizo Matsuka :
歯科補綴学におけるアクティブラーニングの学修効果 反転授業とTBL，通常授業の比較,
The Journal of the Japan Prosthodontic Society, Jul. 2022.
18. Raman Swarna Lakshmi, Waskitho Arief, Kazuo Okura, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka :
Evaluation of tetrahydrobiopterin pathway in orofacial pain model,
Feb. 2022.
19. Waskitho Arief, Yumiko Yamamoto, Raman Swarna Lakshmi, Fumiya Kano, Huijiao Yan, Kazuo Okura, Daisuke Ikutame, Masamitsu Ohshima, Otto Baba, Akihito Yamamoto and Yoshizo Matsuka :
Bilateral botulinum toxin type A effect on orofacial neuropathic pain of animal model,
徳島大学脳科学クラスターミニリトリート, Feb. 2022.
20. Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Miho Inoue, Daisuke Ikutame, Yasutomo Yoshihara, SHINKAI Mizuki, OZAWA Aya and Yoshizo Matsuka :
歯科補綴学授業におけるアクティブラーニングの学修効果―オンライン授業と通常授業，TBL授業の比較―,
大学教育カンファレンス in 徳島, Jan. 2022.
21. Maki Hosoki, Yasufumi Nishikawa, Daisuke Ikutame, Masamitsu Ohshima, Miho Inoue, Aya OZAWA, SHINKAI Mizuki, RAMAN SWARNA LAKSHMI, CHAVAN PARIMAL RAVINDRA, Yasutomo Yoshihara, Kazuo Okura, Yoshitaka Suzuki and Yoshizo Matsuka :
COVID-19対策が日常となった2021年度歯科補綴学実習の評価,
大学教育カンファレンス in 徳島, Jan. 2022.

Et cetera, Workshop:

1. Lutfi P. Perdana, Swarnalakshmi Raman, Jaime Jr. Fabillar, Dara S. Arini, Masamitsu Ohshima, Daisuke Ikutame, Keiko Miyoshi and Yoshizo Matsuka :
Antinociceptive mechanism of IL-10 in trigeminal ganglia of trigeminal neuropathic pain model,
Feb. 2024.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 筋痛モデルラットによる咀嚼筋痛受容機構解明ならびに治療法開発の基盤形成 (Project/Area Number: 23K16069 )
  • BH4 pathway and formation of a foundation for novel therapies for orofacial pain (Project/Area Number: 23K24539 )
  • Analysis of molecular mechanisms of organ size and morphogenesis for dental regenerative medicine (Project/Area Number: 22K10079 )
  • Elucidation of the receptor mechanism of masticatory muscle pain in muscle pain model rats and formation of a basis for the development of therapeutic methods. (Project/Area Number: 21K21042 )
  • Search by Researcher Number (10910218)