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Tokushima UniversityGraduate School of Biomedical Sciences医学域Medical SciencePhysiological Sciences遺伝情報医学
Tokushima UniversityFaculty of MedicineSchool of MedicineCourse of Molecular Medicine遺伝情報医学分野
Tokushima UniversityGraduate School of MedicineMedicineMolecular Medicine
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Research

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Field of Study

Genetics

Subject of Study

遺伝性疾患の原因遺伝子検索と病態解明 (genetics, neurodegeneration, genome editing, genetic engineering, gene therapy)

Book / Paper

Academic Paper (Judged Full Paper):

1. Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hiroyuki Morino, Yui Tada, Mai Kikumoto, Tatsuo Miyamoto, Natsuko Silvia Akutsu, Yukiko Matsuda, Shinya Matsuura, Masahiro Nakamori, Ayumi Nishiyama, Rumiko Izumi, Tetsuya Niihori, Masashi Ogasawara, Nobuyuki Eura, Tamaki Kato, Mamoru Yokomura, Yoshiaki Nakayama, Hidefumi Ito, Masataka Nakamura, Kayoko Saito, Yuichi Riku, Yasushi Iwasaki, Hirofumi Maruyama, Yoko Aoki, Ichizo Nishino, Yuishin Izumi, Masashi Aoki and Hideshi Kawakami :
CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis.,
American Journal of Human Genetics, Vol.110, No.7, 1086-1097, 2023.
(DOI: 10.1016/j.ajhg.2023.05.014,   PubMed: 37339631,   Elsevier: Scopus)
2. Shotaro Haji, Ryosuke Miyamoto, Hiroyuki Morino, Yusuke Osaki, Seijiro Tsuji, Ichizo Nishino, Masahiro Abe and Yuishin Izumi :
Autosomal Recessive Spinocerebellar Ataxia Type 9 With a Response to Phosphate Repletion: A Case Report.,
Neurology. Genetics, Vol.9, No.3, 2023.
(DOI: 10.1212/NXG.0000000000200070,   PubMed: 37529414)
3. Shotaro Haji, Koji Fujita, Ryosuke Oki, Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino, Seiichi Nagano, Naoki Atsuta, Yuki Kanazawa, Yuki Matsumoto, Atsuko Arisawa, Hisashi Kawai, Yasutaka Sato, Satoshi Sakaguchi, Kenta Yagi, Tatsuto Hamatani, Tatsuo Kagimura, Hiroaki Yanagawa, Hideki Mochizuki, Manabu Doyu, Gen Sobue, Masafumi Harada and Yuishin Izumi :
An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study,
JMIR Research Protocols, Vol.12, e42032, 2023.
(Tokushima University Institutional Repository: 118866,   DOI: 10.2196/42032,   PubMed: 36716091,   Elsevier: Scopus)
4. Hidetada Yamada, Shuichiro Neshige, Hiroyuki Morino and Hirofumi Maruyama :
Extubation failure due to atypical parkinsonism with negligible motor and variable non-motor symptoms associated with a variant of DCTN1.,
Internal and Emergency Medicine, 2022.
(DOI: 10.1007/s11739-022-03105-7,   PubMed: 36504048)
5. Hidetada Yamada, Masahiro Nakamori, Junichiro Kuga, Akemi Hironaka, Takamichi Sugimoto, Hiroki Ueno, Tomohiko Ohshita, Hiroyuki Morino and Hirofumi Maruyama :
Nerve Ultrasonography for the Diagnosis and Evaluation of Neuralgic Amyotrophy: A Case Report.,
Internal Medicine, 2022.
(DOI: 10.2169/internalmedicine.0005-22,   PubMed: 36351573)
6. Takashi Kurashige, Hiroyuki Morino, Hiroki Ueno, Tomomi Murao, Tomoaki Watanabe, Takao Hinoi, Ichizo Nishino, Tsuyoshi Torii and Hirofumi Maruyama :
Gastrointestinal cancer occurs as extramuscular manifestation in FSHD1 patients.,
Journal of Human Genetics, 2022.
(Tokushima University Institutional Repository: 118058,   DOI: 10.1038/s10038-022-01095-0,   PubMed: 36336708)
7. Takashi Kurashige, Hiroyuki Morino, Tomomi Murao, Yuishin Izumi, Tomohito Sugiura, Kazuya Kuraoka, Hideshi Kawakami, Tsuyoshi Torii and Hirofumi Maruyama :
TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis.,
JAMA Neurology, Vol.79, No.7, 693-701, 2022.
(DOI: 10.1001/jamaneurol.2022.1113,   PubMed: 35604654)
8. Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki Morino and Hirofumi Maruyama :
Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process,
Frontiers in Molecular Neuroscience, Vol.15, 2022.
(Tokushima University Institutional Repository: 117735,   DOI: 10.3389/fnmol.2022.804702,   Elsevier: Scopus)
9. Kenichi Ishikawa, Mutsuko Araki, Yoshito Nagano, Atsuko Motoda, Takeo Shishido, Takashi Kurashige, Tetsuya Takahashi, Hiroyuki Morino, Hideshi Kawakami, Masayasu Matsumoto and Hirofumi Maruyama :
Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions.,
Differentiation; Research in Biological Diversity, Vol.123, 1-8, 2021.
(DOI: 10.1016/j.diff.2021.11.004,   PubMed: 34844057)
10. Megumi Toko, Tomohiko Ohshita, Takashi Kurashige, Hiroyuki Morino, Kodai Kume, Hiroshi Yamashita, Gen Sobue, Yasushi Iwasaki, Jun Sone, Hideshi Kawakami and Hirofumi Maruyama :
FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report.,
BMC Neurology, Vol.21, No.1, 2021.
(DOI: 10.1186/s12883-021-02425-z,   PubMed: 34641814)
11. Mai Kikumoto, Tomohisa Nezu, Yuji Shiga, Atsuko Motoda, Megumi Toko, Takashi Kurashige, Hiroki Ueno, Tetsuya Takahashi, Hiroyuki Morino, Jun Sone, Yasushi Iwasaki, Gen Sobue and Hirofumi Maruyama :
Case of Neuronal Intranuclear Inclusion Disease With Dynamic Perfusion Changes Lacking Typical Signs on Diffusion-Weighted Imaging.,
Neurology. Genetics, Vol.7, No.4, 2021.
(DOI: 10.1212/NXG.0000000000000601,   PubMed: 34131587)
12. Hidetada Yamada, Shuichiro Neshige, Takeo Shishido, Hiroki Ueno, Tomohiko Ohshita, Hiroyuki Morino and Hirofumi Maruyama :
Efficacy of Lacosamide in a Patient with Refractory Generalized Epilepsy Based on Video Electroencephalography.,
Internal Medicine, Vol.60, No.22, 3621-3624, 2021.
(DOI: 10.2169/internalmedicine.7295-21,   PubMed: 34053987)
13. Tomoyasu Matsubara, Yuishin Izumi, Masaya Oda, Masatoshi Takahashi, Hirofumi Maruyama, Ryosuke Miyamoto, Chigusa Watanabe, Yoshiro Tachiyama, Hiroyuki Morino, Hideshi Kawakami, Yuko Saito and Shigeo Murayama :
An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP-43 proteinopathy,
Neuropathology, Vol.41, No.2, 118-126, 2021.
(DOI: 10.1111/neup.12710,   PubMed: 33415820)
14. Hiroyuki Naito, Tomohisa Nezu, Naohisa Hosomi, Daisuke Kuzume, Shiro Aoki, Yuko Morimoto, Takeshi Yoshida, Teppei Kamimura, Yuji Shiga, Naoto Kinoshita, Hiroki Ueno, Hiroyuki Morino and Hirofumi Maruyama :
Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle-Brachial Index.,
Journal of Atherosclerosis and Thrombosis, Vol.29, No.5, 719-730, 2021.
(DOI: 10.5551/jat.62795,   PubMed: 33790143)
15. Y Kanaya, K Kume, Hiroyuki Morino, R Ohsawa, T Kurashige, M Kamada, T Torii, Yuishin Izumi, H Maruyama and H Kawakami :
Analysis of genetic risk factors in Japanese patients with Parkinson's disease,
Journal of Human Genetics, Vol.66, No.10, 957-964, 2021.
(DOI: 10.1038/s10038-021-00910-4,   PubMed: 33742109,   Elsevier: Scopus)
16. Shuichiro Neshige, Shiro Aoki, Takeo Shishido, Hiroyuki Morino, Koji Iida and Hirofumi Maruyama :
Socio-economic impact on epilepsy outside of the nation-wide COVID-19 pandemic area.,
Epilepsy & Behavior : E&B, Vol.117, 2021.
(DOI: 10.1016/j.yebeh.2021.107886,   PubMed: 33714184)

Review, Commentary:

1. Hiroyuki Morino and 丸山 博文 :
遺伝性ALSオーバービュー,
Clinical Neuroscience, Vol.41, No.3, 330-333, Mar. 2023.

Proceeding of Domestic Conference:

1. Sawaka Yukishige, Hiroaki Inoue, Tomohiro Inui, Souichiro Sasa, Mariko Aoyama, Kazumasa Okumura, Hiroyuki Morino, 吉田 友紀子, 宮本 容子 and Hiromitsu Takizawa :
BRCA遺伝学的検査の結果inconclusiveとなった3例,
第29回日本遺伝性腫瘍学会学術集会, Jun. 2023.
2. YAMAUCHI Shoma, Ryosuke Miyamoto, MUTO Kohei, Yuki Kuwano, KEYOUMU NAZERE, Kensei Nishida, TACHIBANA Konoka, Yuishin Izumi and Hiroyuki Morino :
Search for Pathogenic Variant of ALS by Prioritization based on Phenotype,
第64回日本神経学会学術大会, Jun. 2023.
3. 橘 このか, Ryosuke Miyamoto, Hiroyuki Morino, 福本 竜也, 松本 真一, 目崎 高広, 星野 恭子, Koutaro Asanuma, Takashi Sakamoto, Ryuji Kaji, Yuishin Izumi and Consortium Dystonia Japan :
Genetical and clinical features in a cohort of Japanese patients with dystonia,
第64回日本神経学会学術大会, May 2023.
4. Aya Gohji, Hiroyuki Morino, Asami Okada, Tatsuo Mori, Ken-ichi Suga, Yumiko Kotani, 瀬山 理惠, 内山 由理 and 松本 直通 :
Coffin-siris syndrome with persistent open anterior fontanelle in a boy arising from a novel de novo ARID2 variant,
日本人類遺伝学会第67回大会, Dec. 2022.
5. HANADA Kenta, Yusuke Osaki, Ryosuke Miyamoto, Shotaro Haji, Hiroyuki Morino and Yuishin Izumi :
新規のMORC2変異を認めたCharcot-Marie-Tooth病2Z型の1例,
第112回日本神経学会中国・四国地方会, Dec. 2022.
6. HANADA Kenta, Yusuke Osaki, Ryosuke Miyamoto, Shotaro Haji, Hiroyuki Morino and Yuishin Izumi :
MORC2新規変異を認めたCharcot-Marie-Tooth病2Z型の1例,
第33回日本末梢神経学会学術集会, Sep. 2022.
7. 倉重 毅志, Hiroyuki Morino, 村尾 智美, Yuishin Izumi, 杉浦 智仁, 倉岡 和矢, 川上 秀史, 鳥居 剛 and 丸山 博文 :
ALS患者の筋内神経束でのTDP-43凝集,
第8回日本筋学会学術集会, Aug. 2022.
8. 武藤 浩平, Ryosuke Miyamoto, 沖 良祐, Yoshimichi Miyazaki, 藤井 大樹, 二宮 伸介, 秋山 倫之, Ryuji Kaji, Hiroyuki Morino and Yuishin Izumi :
Geniospasm4,
第63回日本神経学会学術大会, May 2022.
9. MUTO Kohei, Ryosuke Miyamoto, Ryosuke Oki, Yoshimichi Miyazaki, 藤井 大樹, 二宮 伸介, 秋山 倫之, Ryuji Kaji, Hiroyuki Morino and Yuishin Izumi :
本邦におけるGeniospasmの4家系,
第63回日本神経学会学術大会, May 2022.
10. Yusuke Osaki, Ryosuke Miyamoto, Hiroyuki Morino and Yuishin Izumi :
Distal hereditary motor neuropathyを呈したMARS新規変異を有する1家系,
第63回日本神経学会学術大会, May 2022.
11. Yuki Kuwano, Kensei Nishida and Hiroyuki Morino :
m6A RNA methylation of TRA2B4 suppresses cellular senescence of colon cancer,
第44回日本分子生物学会年会, Dec. 2021.
12. Takashi Kurashige, Hiroyuki Morino, Hiroki Ueno, Tomomi Murao, Tomoaki Watanabe, Takao Hinoi, Ichizo Nishino, Tsuyoshi Torii and Hirofumi Maruyama :
Gastrointestinal cancer occurs as extramuscular manifestation in FSHD1 patients,
日本人類遺伝学会第66回大会, Oct. 2021.
13. 原 直之, Hiroyuki Morino, 松田 由喜子, 佐藤 健一, 橋本 浩一, 丸山 博文 and 川上 秀史 :
Zonisamide can ameliorate the conduction of the mutant CaV3.1 that causes spinocerebellar ataxia,
第62回日本神経学会学術大会, May 2021.
14. 松田 由喜子, Hiroyuki Morino, 外丸 祐介, 倉重 毅志, 丸山 博文 and 川上 秀史 :
Transcriptomic analysis using model mice of spinocerebellar ataxia 42,
第62回日本神経学会学術大会, May 2021.

Et cetera, Workshop:

1. Hiroyuki Morino :
遺伝的要因から考えるパーキンソン病の発症機序と治療戦略,
第42回症例から学ぶ神経内科 in 広島, Feb. 2022.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Elucidation of alpha-synuclein aggregation mechanism in Parkinson's disease and application to novel therapeutic strategies (Project/Area Number: 23K06828 )
  • Necroptosisを介したALSの運動神経変性の病態機序と新規治療の探索 (Project/Area Number: 23H02827 )
  • 新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発 (Project/Area Number: 22H02950 )
  • A new oligonucleotide treatment with CRISPR/Cas13 using model mice of spinocerebellar ataxia (Project/Area Number: 19K07994 )
  • Identification of TDP-43 related genes using gene trap (Project/Area Number: 16K15481 )
  • Evaluation of involvement in neurodegeneration by collapse of mitochondrial DNA maintenance mechanism using iPS cells (Project/Area Number: 15K15083 )
  • Study of cerebellum disturbance by genetic approaches (Project/Area Number: 26242085 )
  • Elucidation of the molecular mechanism caused by the neurotoxicity of OPTN mutations in ALS (Project/Area Number: 23591246 )
  • Novel Genes of Autosomal Recessive Spinocerebellar Degeneration (Project/Area Number: 19390241 )
  • Search by Researcher Number (10397953)