徳島大学 / 教育研究者総覧 --- 原知也

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徳島大学 ⟩ 病院 ⟩ 先端医科医療開発研究プロジェクト ⟩
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著書・論文

学術論文(審査論文):

1.	Tomoya Hara and Masataka Sata : Current Real-World Status of Oral Anticoagulant Management in Japanese Patients, Circulation Journal, 2024. (要約) Anticoagulant therapy is a drug therapy that inhibits the formation of blood clots. Although anticoagulants are effective in preventing thromboembolism, they also carry the risk of bleeding, so they must be managed carefully, taking both efficacy and safety into account. Evidence regarding the effectiveness and safety of each anticoagulant has already accumulated through many large clinical trials and post-marketing surveillance. However, when making decisions in clinical practice, it is necessary to always take into consideration differences in patient populations between clinical trials and actual clinical practice, as well as differences in historical background. (For example, there are differences in antiplatelet drugs and coronary artery interventions that were mainly used in each era.) In this review we discuss the effectiveness and safety of currently used anticoagulants, focusing on different patient backgrounds and points to keep in mind regarding their proper use, based on the latest reports in Asian populations, especially Japanese people, over the past 1-2 years. (徳島大学機関リポジトリ) ● Metadata: 119653 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-24-0827 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39551528 ● Search Scopus @ Elsevier (PMID): 39551528 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-24-0827 (徳島大学機関リポジトリ: 119653, DOI: 10.1253/circj.CJ-24-0827, PubMed: 39551528)
2.	Shusuke Yagi, Muneyuki Kadota, Ryo Bando, Ryosuke Miyamoto, Hiroyuki Morino, Akiyoshi Kakutani, Yoshiaki Kubo, Takayuki Ise, Rie Ueno, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Daiju Fukuda and Masataka Sata : Pulmonary Arterial Hypertension in Neurofibromatosis Type 1: A Case with a Novel NF1 Gene Mutation, Internal Medicine, 2024. (要約) Neurofibromatosis type 1 (NF1) is an autosomal dominant multi-organ disease. The clinical manifestations include not only skin lesions and malignant tumors but also lung complications, including pulmonary arterial hypertension (PAH). However, the association between gene mutations in NF1 and the occurrence of PAH has not yet been elucidated. We herein report a case of isolated PAH in a 67-year-old woman with NF1, presumably caused by a novel heterozygous mutation, c.4485_4486delinsAT (p.Lys1496Ter), in the NF1 gene. (徳島大学機関リポジトリ) ● Metadata: 119521 (出版サイトへのリンク) ● Publication site (DOI): 10.2169/internalmedicine.3856-24 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38987187 ● Search Scopus @ Elsevier (PMID): 38987187 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.3856-24 (徳島大学機関リポジトリ: 119521, DOI: 10.2169/internalmedicine.3856-24, PubMed: 38987187)
3.	Uugantsetseg Munkhjargal, Daiju Fukuda, J Maeda, Tomoya Hara, S Okamoto, O Bavuu, Takayuki Yamamoto and Masataka Sata : LCZ696, an Angiotensin Receptor-Neprilysin Inhibitor, Ameliorates, Journal of Atherosclerosis and Thrombosis, Vol.31, No.9, 1333-1340, 2024. (徳島大学機関リポジトリ) ● Metadata: 119293 (出版サイトへのリンク) ● Publication site (DOI): 10.5551/jat.64468 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38616113 ● Search Scopus @ Elsevier (PMID): 38616113 ● Search Scopus @ Elsevier (DOI): 10.5551/jat.64468 (徳島大学機関リポジトリ: 119293, DOI: 10.5551/jat.64468, PubMed: 38616113)
4.	Munkhtsetseg Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Lipoprotein (a) is a risk factor of aortic valve calcification in patients with a risk of atherosclerosis, The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 450-456, 2023. (要約) Aortic valve calcification (AVC), which causes aortic stenosis (AS), is more common in elderly persons. Controlling for conventional risk variables did not, however, reduce the incidence of AS. Thus, residual risk factors of AS should be identified. We enrolled 513 patients who underwent coronary angiography with computed tomography because of suspicion of coronary artery disease (CAD) or ruling out of CAD before aortic valve replacement. Calcium volume was calculated with a commercially available application. Conventional and lipid-related risk factors including serum levels of Lp(a) were evaluated for all patients. Calcium volume and Lp(a) levels were significantly higher in patients who underwent aortic valve replacement than in those who did not. A single regression analysis showed that the calcium volume was positively associated with age and the Lp(a) levels and negatively associated with the estimated glomerular filtration rate. No statistical significance was observed for other risk factors, including oxidized low-density lipoprotein, omega-3 fatty acids levels. The multiple regression analysis revealed that age (P<0.001), female sex (P<0.05), Lp(a) (P<0.01), and hemoglobin A1c (P<0.01) were determinants of the calcium volume. The area under the curve in receiver operating characteristic analysis of Lp(a) for implementation of AVR was 0.65 at an Lp(a) cut-off level of 16 mg/dL. In conclusion, the serum Lp(a) level is a potent risk factor of AVC in patients with high risk of atherosclerosis. J. Med. Invest. 70 : 450-456, August, 2023. (キーワード) Humans / Female / Aged / Aortic Valve / Lipoprotein(a) / Calcium / Aortic Valve Stenosis / Atherosclerosis / Risk Factors / Coronary Artery Disease (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.70.450 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940531 ● Search Scopus @ Elsevier (PMID): 37940531 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.450 (DOI: 10.2152/jmi.70.450, PubMed: 37940531)
5.	Tomoya Hara, Daiju Fukuda, Byambasuren Ganbaatar, Phuong Tran Pham, Kunduziayi Aini, Arief Rahadian, Kumiko Suto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in apolipoprotein E-deficient mice, Heart and Vessels, Vol.38, No.11, 1386-1394, 2023. (要約) The Mediterranean diet, which is characterized by high consumption of olive oil, prevents cardiovascular disease. Meanwhile, olive mill wastewater (OMWW), which is obtained as a byproduct during olive oil production, contains various promising bioactive components such as water-soluble polyphenols. Hydroxytyrosol (HT), the major polyphenol in OMWW, has anti-oxidative and anti-inflammatory properties; however, the atheroprotective effects of OMWW and HT remain to be fully understood. Here, we investigated the effect of OMWW and HT on atherogenesis. Male 8-week-old apolipoprotein E-deficient mice were fed a western-type diet supplemented with OMWW (0.30%w/w) or HT (0.02%w/w) for 20 weeks. The control group was fed a non-supplemented diet. OMWW and HT attenuated the development of atherosclerosis in the aortic arch as determined by Sudan IV staining (P < 0.01, respectively) without alteration of body weight, plasma lipid levels, and blood pressure. OMWW and HT also decreased the production of oxidative stress (P < 0.01, respectively) and the expression of NADPH oxidase subunits (e.g., NOX2 and p22phox) and inflammatory molecules (e.g. IL-1β and MCP-1) in the aorta. The results of in vitro experiments demonstrated that HT inhibited the expression of these molecules that were stimulated with LPS in RAW264.7 cells, murine macrophage-like cells. OMWW and HT similarly attenuated atherogenesis. HT is a major component of water-soluble polyphenols in OMWW, and it inhibited inflammatory activation of macrophages. Therefore, our results suggest that the atheroprotective effects of OMWW are at least partially attributable to the anti-inflammatory effects of HT. (徳島大学機関リポジトリ) ● Metadata: 118456 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00380-023-02290-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37462755 ● Search Scopus @ Elsevier (PMID): 37462755 ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-023-02290-5 (徳島大学機関リポジトリ: 118456, DOI: 10.1007/s00380-023-02290-5, PubMed: 37462755)
6.	Shusuke Yagi, Tomoya Hara, Hirotsugu Yamada, Kenya Kusunose, Takayuki Ise and Masataka Sata : Intimal Sarcoma of the Pulmonary Artery as an Embolic Cause of Sudden Death, Circulation Journal, Vol.87, No.7, 1036, 2023. (徳島大学機関リポジトリ) ● Metadata: 118374 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-23-0029 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37245990 ● Search Scopus @ Elsevier (PMID): 37245990 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-23-0029 (徳島大学機関リポジトリ: 118374, DOI: 10.1253/circj.CJ-23-0029, PubMed: 37245990)
7.	Tomoya Hara, Masataka Sata and Daiju Fukuda : Emerging roles of Protease-Activated Receptors in Cardiometabolic Disorders, Journal of Cardiology, Vol.81, No.4, 337-346, 2023. (要約) Cardiometabolic disorders, including obesity-related insulin resistance and atherosclerosis, share sterile chronic inflammation as a major cause; however, the precise underlying mechanisms of chronic inflammation in cardiometabolic disorders are not fully understood. Accumulating evidence suggests that several coagulation proteases, including thrombin and activated factor X (FXa), play an important role not only in the coagulation cascade but also in the proinflammatory responses through protease-activated receptors (PARs) in many cell types. Four members of the PAR family have been cloned (PAR 1-4). For instance, thrombin activates PAR-1, PAR-3, and PAR-4. FXa activates both PAR-1 and PAR-2, while it has no effect on PAR-3 or PAR-4. Previous studies demonstrated that PAR-1 and PAR-2 activated by thrombin or FXa promote gene expression of inflammatory molecules mainly via the NF-κB and ERK1/2 pathways. In obese adipose tissue and atherosclerotic vascular tissue, various stresses increase the expression of tissue factor and procoagulant activity. Recent studies indicated that the activation of PARs in adipocytes and vascular cells by coagulation proteases promotes inflammation in these tissues, which leads to the development of cardiometabolic diseases. This review briefly summarizes the role of PARs and coagulation proteases in the pathogenesis of inflammatory diseases and describes recent findings (including ours) on the potential participation of this system in the development of cardiometabolic disorders. New insights into PARs may ensure a better understanding of cardiometabolic disorders and suggest new therapeutic options for these major health threats. (徳島大学機関リポジトリ) ● Metadata: 117567 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jjcc.2022.09.013 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36195252 ● Search Scopus @ Elsevier (PMID): 36195252 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jjcc.2022.09.013 (徳島大学機関リポジトリ: 117567, DOI: 10.1016/j.jjcc.2022.09.013, PubMed: 36195252)

国際会議:

1.	Tezuka Kazuki, Takeshi Soeki, Tomoko Takahashi, Tomomi Matsuura, Akihiro Tani, Ryo Bando, R Zheng, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Rie Ueno, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : Risk Factors For Intraoperative Instability In Sedated Patients Undergoing Pulmonary Vein Isolation Ablation, Sydney, Sep. 2024.
2.	Tomoko Takahashi, Takeshi Soeki, Tezuka Kazuki, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Yutaka Kawabata, Muneyuki Kadota, Rie Ueno, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : NAFLD score predicts the onset of atrial fibrillation, APHRS 2024, Sydney, Sep. 2024.
3.	Yoshihito Saijo, Hirotsugu Yamada, Robert Zheng, TOMONORI Takahashi, Yutaka Kawabata, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Differential echocardiographic profiles in immunoglobulin light chain and transthyretin amyloid cardiomyopathy: insights from speckle tracking analysis, ESC 2024, London, Aug. 2024.
4.	Kumiko Suto, Tomoya Hara, Sachiko Nishimoto, S Kaneyama, Masataka Sata and Daiju Fukuda : Macrophage-Specific DNaseII Deficiency Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice, AHA2023, Philadelphia, Nov. 2023.

国内講演発表:

1.	西條良仁, 山田博胤, Zheng Robert, 髙橋智紀, 坂東遼, 高橋智子, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 笹聡一郎, 滝沢宏光, 佐田政隆 : Mechanical circulatory supportを要した重症がん治療関連心機能障害の1例, 第124回日本循環器学会中国・四国合同地方会, 2024年6月.
2.	八木一成, 八木秀介, 西條良仁, 高橋智子, Zheng Robert, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 秦広樹, 菅野幹雄 : 心室中隔欠損症・感染性心内膜炎を合併した大動脈縮窄証による二次性高血圧症の一例, 第124回日本循環器学会中国・四国合同地方会, 2024年6月.
3.	Ryo Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, TOMONORI Takahashi, Hayato Orino, Issei Yagi, TOMONORI Takahashi, Zheng Robert, Yoshihito Saijyo, Tomoya Hara, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Predictors of Late Lumen Enlargement after Drug Coated Balloon Angioplasty for de Novo Coronary Lesions, 第88回日本循環器学会学術集会 JCS2024, Mar. 2024.
4.	Tomoya Hara, Daiju Fukuda and Masataka Sata : Activated Factor X/Protease-activated Receptor-2 Axis Plays a Pivotal Role in Vascular Inflammation and Atherosclerosis, 第88回日本循環器学会学術集会 JCS2024, Mar. 2024.
5.	Kumiko Suto, Tomoya Hara, Sachiko Nishimoto, S Kaneyama, Masataka Sata and Daiju Fukuda : Macrophage-Specific DNaseII Deficiency Stimulates Vascular Inflammation and Atherosclerosis, 第88回日本循環器学会学術集会 JCS2024, Mar. 2024.
6.	Yoshihito Saijyo, Hirotsugu Yamada, 長野絋平, 折野逸人, 八木一成, TAKAHASHI Tomoko, Zengu Robahto, BANDO Ryo, TOMONORI Takahashi, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Incremental Value of Relative Apical Sparing Index for Discrimination of Cardiac Amyloidosis Subtypes, 第88回日本循環器学会学術集会, Mar. 2024.
7.	M Tserensonom, Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Muneyuki Kadota, Tomoya Hara, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : High Serum lipoprotein (a) level is a risk factor of poor prognosis after transcatheter aortic valve implantation, 第88回日本循環器学会学術集会 JCS2024, Mar. 2024.
8.	八木一成, 西條良仁, 長野絋平, 折野逸人, 吉田直史, 髙橋智子, Robert Zheng, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 : ALおよびATTR心アミロイドーシス間のエコー図検査的特徴の相違に関する検討, 第123回日本循環器学会四国支部地方会, 2023年12月.
9.	Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, TOMONORI Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata : Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels, 第87回日本循環器学会学術集会, Mar. 2023.
10.	Yoshihito Saijyo, Yuichiro Okushi, Kenya Kusunose, Hirotsugu Yamada, Zengu Robahto, TOMONORI Takahashi, Hiromitsu Seno, Susumu Nishio, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Utility of Periodic Echocardiographic Surveillance for Early Detection of Cardiac Dysfunction from Chemotherapy in Breast Cancer Patients, 第87回日本循環器学会学術集会, Mar. 2023.
11.	Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, BANDO Ryo, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : The Impact of Coronary Plaque Progression Stage on Coronary Neovascularization Structures in Fresh Cadavers, 第87回日本循環器学会学術集会, Mar. 2023.
12.	松崎慶仁, 西條良仁, 伊勢孝之, 太田啓太, 折野逸人, 吉田知哉, 根岸佑典, 宮本亮太, 坂東遼, Rovert Zheng, 瀬野弘光, 高橋智紀, 上野理絵, 門田宗之, 原知也, 川端豊, 松浦朋美, 楠瀬賢也, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 : 急性A型大動脈解離をきたしたMarfan症候群の一例, 第265回徳島県医学学術集会, 2022年7月.
13.	根岸佑典, 門田宗之, 山口浩司, 山田博胤, 折野逸人, 太田啓太, 吉田知哉, 宮本亮太, 坂東遼, Robert Zheng, 瀬野弘光, 高橋智紀, 西條良仁, 上野理絵, 原知也, 川端豊, 松浦朋美, 伊勢孝之, 楠瀬賢也, 八木秀介, 添木武, 若槻哲三, 田蒔昌憲, 佐田政隆 : 腎動脈拡張術により心不全の著名な改善を認めたCardiac Disturbance syndrome の1例, 第265回徳島県医学学術集会, 2022年7月.
14.	八木秀介, 伊勢孝之, 門田宗之, 川端豊, 原知也, 上野理絵, 西條良仁, 松浦朋美, 楠瀬賢也, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆 : パンデミック下の臨床実習におけるオンライン医学教育の実際と問題点, 第265回徳島県医学学術集会, 2022年6月.

その他・研究会:

1.	相原弘幸, 坂東遼, 松本遼太, 曽我部公子, Zheng Robert, 髙橋智紀, 西條良仁, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 藤井志朗, 秦広樹, 佐田政隆 : 学生・研修医セッション1(冠動脈)血友病A患者における重症三枝病変に対する冠動脈バイパス術の一例, 第125回日本循環器学会四国地方会, 2024年12月.
2.	伊藤直司, 西條良仁, 手束一貴, 高橋智子, 谷彰浩, 坂東遼, ロバートゼング, 髙橋智紀, 門田宗之, 川端豊, 上野理絵, 原知也, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 松本遼太, 秦広樹, 佐田政隆 : ポスタ-セッション健康診断を契機に発見された巨大冠動脈瘤の一例, 第269回徳島医学会学術集会, 2024年7月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

DNase IIが血管の炎症と動脈硬化に与える影響の検討 (研究課題/領域番号: 23K15132 )
活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の解明 (研究課題/領域番号: 26860565 )
研究者番号（00644577）による検索