徳島大学 / 教育研究者総覧 --- 髙橋智紀

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徳島大学 ⟩ 病院 ⟩ 診療科 ⟩ 内科 ⟩ 循環器内科 ⟩

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学術論文(審査論文):

1.	Sanae Morita, Yukina Hirata, Susumu Nishio, Tomonori Takahashi, Yoshihito Saijo, Hirotsugu Yamada, Masataka Sata and Kenya Kusunose : Correlation between energy loss index and B-type natriuretic peptide: a vector flow mapping study, Journal of Echocardiography, 2023. (要約) Vector Flow Mapping (VFM) and Energy Loss (EL) evaluation are emerging echocardiographic techniques that offer detailed insights into cardiac function. This study aimed to explore the relationship between EL parameters and B-type natriuretic peptide (BNP) levels, a well-established marker of heart failure severity. Our study prospectively enrolled 62 patients experiencing shortness of breath and suspected heart failure, who underwent echocardiography and had BNP levels measured between January 2018 and August 2020. Patients were stratified based on BNP levels, and their clinical and echocardiographic characteristics were evaluated. Univariate and multivariate regression analyses were performed to assess the correlation between BNP levels and various echocardiographic variables, including VFM parameters. Patients were stratified into two groups based on their BNP levels: BNP < 200 pg/ml (n = 53) and BNP ≥ 200 pg/ml (n = 9). Patients with BNP ≥ 200 pg/ml presented significantly different clinical and echocardiographic characteristics, such as older age, larger left ventricular mass and volume indices, higher pulmonary artery systolic pressure, higher E/e' ratio, and larger EL parameters. Multivariate regression analysis demonstrated the E/e' ratio and ELA (EL during Atrial contraction phase/A wave ratio as significant determinants of logBNP. Receiver operating characteristic curve analysis showed ELA/A > 36.0 J/m as a significant predictor of high BNP with 89% sensitivity and 85% specificity. ELA/A demonstrated an incremental diagnostic value over elevated left atrial pressure for predicting high BNP (C statistic = 0.98 vs 0.74, P = 0.006). This study provides novel insights into the potential utility of EL parameters as auxiliary indicators of cardiac load, thereby enhancing our understanding of heart failure. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-023-00623-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37707682 ● Summary page in Scopus @ Elsevier: 2-s2.0-85170841573 (DOI: 10.1007/s12574-023-00623-x, PubMed: 37707682, Elsevier: Scopus)
2.	Yuichiro Okushi, Yoshihito Saijyo, Hirotsugu Yamada, Hiroaki Toba, Robert Zheng, Hiromitsu Seno, Tomonori Takahashi, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose : Effectiveness of surveillance by echocardiography for Cancer therapeutics-related cardiac dysfunction of patients with breast Cancer, Journal of Cardiology, Vol.S0914-5087, No.23, 00162-00164, 2023. (要約) Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jjcc.2023.07.002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37481235 ● Summary page in Scopus @ Elsevier: 2-s2.0-85166962366 (DOI: 10.1016/j.jjcc.2023.07.002, PubMed: 37481235, Elsevier: Scopus)
3.	Tomonori Takahashi, Kenya Kusunose, S Hayashi, Robert Zheng, Natsumi Yamaguchi, Sae Morita, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Isoproterenol loading transesophageal echocardiography in atrial fibrillation, The International Journal of Cardiovascular Imaging, Vol.39, No.3, 511-518, 2023. (要約) In patients with sludge or severe spontaneous echo contrast (SEC) in the left atrial appendage (LAA), cases with isoproterenol loading transesophageal echocardiography (ISP-TEE) have been reported to identify the presence of thrombus in the LAA. This study aimed to assess the validity and hemodynamic changes of ISP-TEE in the LAA. We prospectively enrolled patients with atrial fibrillation (AF) who underwent ISP-TEE. The degree of sludge/SEC was categorized as being either absent (grade 0), mild SEC (grade 1), moderate SEC (grade 2), severe SEC or sludge (grade 3). The hemodynamic evaluation was performed by measuring LAA flow velocity, LAA tissue Doppler imaging (LAA-TDI) velocity, and pulmonary vein systolic forward flow velocity (PVS). In total, 35 patients (mean age 71 ± 7 years; 71% male) underwent ISP-TEE. Among 35 patients, 30 patients had grade 3 or 2 SEC, 5 patients had grade 1 SEC. After ISP loading, 23 patients (66% of all patients) showed improved sludge/SEC and one patient was diagnosed with thrombus in the LAA. There were 25 patients with grade 1 SEC, or no SEC (classified as Group1), 10 patients had residual sludge or grade 2 to 3 SEC (classified as Group2) after ISP administration. LAA flow, LAA-TDI, and PVS velocities were significantly higher in group 1 than in group 2 after ISP administration. There was no complication during the examination and after 24 h and 3 months. ISP infusion may be a potential tool to recognize LAA thrombus under the sludge/SEC during TEE in AF. (キーワード) Humans / Male / Middle Aged / Aged / Female / Atrial Fibrillation / Echocardiography, Transesophageal / Isoproterenol / Sewage / Atrial Appendage / Predictive Value of Tests / Thrombosis (徳島大学機関リポジトリ) ● Metadata: 118275 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10554-022-02749-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36357528 ● Search Scopus @ Elsevier (PMID): 36357528 ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-022-02749-y (徳島大学機関リポジトリ: 118275, DOI: 10.1007/s10554-022-02749-y, PubMed: 36357528)

国際会議:

1.	Tomonori Takahashi, Tetsuzo Wakatsuki, Kenya Kusunose, Takayuki Ise and Masataka Sata : The aneurysm that vanished into thin air:Spontaneous thrombosis of a giant aneurysm complicated with the coronary to pulmonary artery fistula, ESC2023, Amsterdam, Aug. 2023.
2.	Ryou Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Tomonori Takahashi, Yoshihito Saijyo, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, S Yagi, Hirotsugu Yamada, T Soeki, M Akaike and Masataka Sata : Two-year outcomes of drug-coated balloon only strategy for de novo lesions in large coronary vessels, ESC2023, Amsterdam, Aug. 2023.
3.	Y Okushi, Kenya Kusunose, Hiromitsu Seno, Tomonori Takahashi, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : The Impact of Surveillance of Cancer Therapeutics-Related Cardiac Dysfunction by Periodic Echocardiography, ASE2022, Seattle, Jun. 2022.

国内講演発表:

1.	平田有紀奈, 楠瀬賢也, 山口夏美, 森田沙瑛, 湯浅麻美, 松本力三, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 : 上腕動脈における血管柔軟性と性差・加齢との関係 ∼ViewWaveを用いた検討∼, 第71回日本心臓病学会学術集会，2023年9月8日(金)∼10日(日)，東京, 2023年9月.
2.	西尾進, 楠瀬賢也, 野村侑香, 山口夏美, 湯浅麻美, 松本力三, 平田有紀奈, Robahto Zengu, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 : HFpEFに対する脈波増大指数の影響∼SphygmoCor-XCEL®を用いた検討∼, 第71回日本心臓病学会学術集会, 2023年9月.
3.	坂東遼, 山口浩司, 若槻哲三, 伊勢孝之, 川端豊, 髙橋智紀, Zheng Robert, 高橋智子, 吉田直史, 佐田政隆 : 薬剤塗布バルーン治療後に認めた遠隔期血管内腔拡大の長期観察, 第29回日本心血管インターヘンション治療学会(CVIT)中国四国地方会, 2023年9月.
4.	長野紘平, 髙橋智紀, 折野逸人, 大谷啓太, 根岸佑典, 八木一成, 吉田直史, ロバートゼング, 坂東遼, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 : 高血圧リスク患者に対する薬剤コーティングバルーンを用いたstentless PCI 治療の長期成績, 第29回日本心血管インターヘンション治療学会(CVIT)中国四国地方会, 2023年9月.
5.	Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Tomonori Takahashi, Takayuki Ise and Masataka Sata : Association of coronary plaque characteristics with vasa vasorum and local inflammation of epicardial adipose tissue in fresh cadavers, CVIT2023, Aug. 2023.
6.	Koji Yamaguchi, Tetsuzo Wakatsuki, Ryo Bando, Tomonori Takahashi, Yutaka Kawabata, Takayuki Ise and Masataka Sata : Limitations of treatment for severely calcified lesions of renal arteries, CVIT2023, Aug. 2023.
7.	湯浅麻美, 西尾進, 山口夏美, 森田沙瑛, 松本力三, 平田有紀奈, 山尾雅美, Robert Zheng, 大櫛祐一郎, 瀬野弘光, 髙橋智紀, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 : ヘルスクロノスを用いた冠動脈狭窄検出の試み, 第8回日本血管不全学会学術集会, 2023年4月.
8.	西尾進, 楠瀬賢也, 平田有紀奈, 山口夏美, Robert Zheng, 髙橋智紀, 瀬野弘光, 西條良仁, 山田博胤, 佐田政隆 : 心エコー図検査における2Dストレイン計測の現状と課題, 第87回日本循環器学会学術集会, 2023年3月.
9.	BANDO Ryo, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, Tomonori Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata : Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels, 第87回日本循環器学会学術集会, Mar. 2023.
10.	Yoshihito Saijyo, Yuichiro Okushi, Kenya Kusunose, Hirotsugu Yamada, Zengu Robahto, Tomonori Takahashi, Hiromitsu Seno, Susumu Nishio, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Utility of Periodic Echocardiographic Surveillance for Early Detection of Cardiac Dysfunction from Chemotherapy in Breast Cancer Patients, 第87回日本循環器学会学術集会, Mar. 2023.
11.	Takayuki Ise, Shusuke Yagi, Rie Ueno, Muneyuki Kadota, Keita Ohtani, Yusuke Negishi, Ryota Miyamoto, BANDO Ryo, Zengu Robahto, Hiromitsu Seno, Tomonori Takahashi, Yutaka Kawabata, Yoshihito Saijyo, Tomomi Matsuura, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Novel Home-based Cardiac Telerehabilitation System Using a Wearable Device and a Web Application, 第87回日本循環器学会学術集会, Mar. 2023.
12.	Koji Yamaguchi, Tetsuzo Wakatsuki, Tomonori Takahashi, Yutaka Kawabata, Takayuki Ise and Masataka Sata : The impact of polymer duration on local coagulative responses following drug-eluting stent implantation, 第30回日本心血管インターベンション治療学会学術集会, Jul. 2022.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

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