徳島大学 / 教育研究者総覧 --- 髙橋智紀

専門分野

研究テーマ

著書・論文

学術論文(審査論文):

1.	TOMONORI Takahashi, Tetsuzo Wakatsuki, Takayuki Ise and Masataka Sata : Spontaneous thrombosis of a giant aneurysm complicated with the coronary-to-pulmonary artery fistula: a case report, European Heart Journal. Case Reports, Vol.8, 2024. (要約) Background A coronary-to-pulmonary artery fistula (CPAF) with a giant aneurysm is a rare clinical occurrence. The rupture of an aneurysm leads to a fatal outcome, thus prompting the incorporation of prophylactic measures, which have encompassed surgical resections or endovascular embolization procedures. The indications for these treatment strategies are controversial, and little has been elucidated regarding the salient characteristics underpinning the selection of a therapeutic strategy. We report a case of a giant aneurysm associated with CPAFs that was thrombosed before interventional treatment. Case summary A 43-year-old woman, who had previously undergone a right adrenalectomy for primary aldosteronism, was referred for an abnormal heart silhouette on a chest X-ray, which had not been seen three years earlier. Contrast-enhanced computed tomography and coronary angiography (CAG) revealed a giant aneurysm on the anterior aspect of the heart associated with two CPAFs. Because of the risk of rupture of the aneurysm, surgical resection was recommended; however, the patient requested endovascular therapy. On the day of intervention, CAG showed spontaneous occlusion of the feeding vessel to the aneurysm, and the aneurysm showed minimal contrast agent, suggesting spontaneous thrombosis. Because of possible recanalization of the aneurysm, coil embolization was performed, without complications. The patient remained asymptomatic, and the aneurysm was completely embolized at the one-year follow-up. Discussion The case shows that minimally invasive endovascular treatment is feasible instead of surgical resection for giant aneurysms associated with CPAFs, depending on their morphological characteristics. This perspective may offer novel insights into treatment strategies for CPAF. (キーワード) Coronary-to-pulmonary artery fistulas / Coronary anomalies / Coronary anomalies / Case report (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjcr/ytae227 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1871709542841104768 ● Summary page in Scopus @ Elsevier: 2-s2.0-85192932221 (DOI: 10.1093/ehjcr/ytae227, CiNii: 1871709542841104768, Elsevier: Scopus)
2.	Yoshihito Saijyo, Kenya Kusunose, TOMONORI Takahashi, Hirotsugu Yamada, Masataka Sata, Kimi Sato, Noor Albakaa, Tomoko Ishizu, Yoshihiro Seo and JSE TAVI investigators : Impact of Transcatheter Aortic Valve Replacement on Cardiac Reverse Remodeling and Prognosis in Mixed Aortic Valve Disease, Journal of the American Heart Association, Vol.13, No.4, e033289, 2024. (要約) The management of mixed aortic valve disease (MAVD), defined as the concomitant presence of aortic stenosis (AS) and aortic regurgitation, remains a clinical challenging. The present study assessed the impact of transcatheter aortic valve replacement (TAVR) on cardiac geometry and prognosis in patients with MAVD. A retrospective multicenter TAVR registry was conducted, including patients who underwent TAVR for severe symptomatic AS between January 2015 and March 2019. Patients were subdivided into 2 groups according to concomitant presence of moderate or more severe aortic regurgitation as the MAVD group, and with mild or less severe aortic regurgitation as the isolated AS group. The primary outcome was a composite of cardiovascular death and rehospitalization due to cardiovascular causes. A total of 1742 patients (isolated AS, 1522 patients; MAVD, 220 patients) were included (84.0±5.2 years). Although MAVD exhibited significantly larger left ventricular volumes and higher left ventricular mass index at the TAVR procedure than isolated AS (respectively, <0.001), MAVD showed a greater improvement of left ventricular volumes and left ventricular mass index after TAVR (respectively, ≤0.001). During a median follow-up of 747 days, 301 patients achieved the primary event. The prognosis post-TAVR was comparable between the 2 groups (log-rank =0.65). Even after adjustment using propensity score matching to reduce the potential bias between the 2 groups, similar results were obtained for the entire cohort. Despite more advanced cardiac remodeling in MAVD at the time of TAVR compared with isolated AS, a greater improvement of cardiac reverse remodeling was found in MAVD, and the prognosis following TAVR was comparable between the 2 groups. (キーワード) Humans / Transcatheter Aortic Valve Replacement / Aortic Valve / Aortic Valve Insufficiency / Treatment Outcome / Risk Factors / Aortic Valve Stenosis / Prognosis / Retrospective Studies / Severity of Illness Index / Ventricular Function, Left (出版サイトへのリンク) ● Publication site (DOI): 10.1161/JAHA.123.033289 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38362873 ● Search Scopus @ Elsevier (PMID): 38362873 ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.123.033289 (DOI: 10.1161/JAHA.123.033289, PubMed: 38362873)
3.	N Yamaguchi, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose : Pulmonary Pressure-flow responses to exercise in heart failure treated with angiotensin receptor neprilysin inhibitor., International Journal of Cardiology, Vol.400, 131789, 2024. (要約) The role of the angiotensin receptor neprilysin inhibitor (ARNI) in cardiac function, particularly its impact on pulmonary circulation, remains underexplored. Recent studies have described abnormal mean pulmonary artery pressure (mPAP)-cardiac output (CO) responses as having the potential to assess the disease state. The aim of this study was to assess the effects of ARNI on pulmonary circulation in heart failure. We measured echocardiographic parameters post 6-min walk (6 MW) and compared the changes with baseline and follow-up. Our hypothesis was that pulmonary pressure-flow relationship of the pulmonary circulation obtained by 6 MW stress echocardiography would be improved with treatment. We prospectively enrolled 39 heart failure patients and conducted the 6 MW test indoors. Post-6 MW echocardiography measured echocardiographic variables, and CO was derived from electric cardiometry. Individualized ARNI doses were optimized, with follow-up echocardiographic evaluations after 1 year. Left ventricular (LV) volume were significantly reduced (160.7 ± 49.6 ml vs 136.0 ± 54.3 ml, P < 0.001), and LV ejection fraction was significantly improved (37.6 ± 11.3% vs 44.9 ± 11.5%, P < 0.001). Among the 31 patients who underwent 6 MW stress echocardiographic study at baseline and 1 year later, 6 MW distance increased after treatment (380 m vs 430 m, P = 0.003). The ΔmPAP/ΔCO by 6 MW stress decreased with treatment (6.9 mmHg/L/min vs 2.8 mmHg/L/min, P = 0.002). The left atrial volume index was associated with the response group receiving ARNI treatment for pulmonary circulation. Initiation of ARNI was associated with improvement of left ventricular size and LVEF. Additionally, the 6 MW distance increased and the ΔmPAP/ΔCO was improved to within normal range with treatment. (徳島大学機関リポジトリ) ● Metadata: 118925 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijcard.2024.131789 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38246422 ● Search Scopus @ Elsevier (PMID): 38246422 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2024.131789 (徳島大学機関リポジトリ: 118925, DOI: 10.1016/j.ijcard.2024.131789, PubMed: 38246422)
4.	Kenya Kusunose, T Tsuji, Yukina Hirata, TOMONORI Takahashi, Masataka Sata, K Sato, N Albakaa, T Ishizu, J Kotoku and Y Seo : Unsupervised cluster analysis reveals different phenotypes in patients after transcatheter aortic valve replacement, European Heart Journal Open, Vol.4, No.1, oead136, 2023. (要約) The aim of this study was to identify phenotypes with potential prognostic significance in aortic stenosis (AS) patients after transcatheter aortic valve replacement (TAVR) through a clustering approach. This multi-centre retrospective study included 1365 patients with severe AS who underwent TAVR between January 2015 and March 2019. Among demographics, laboratory, and echocardiography parameters, 20 variables were selected through dimension reduction and used for unsupervised clustering. Phenotypes and outcomes were compared between clusters. Patients were randomly divided into a derivation cohort ( = 1092: 80%) and a validation cohort ( = 273: 20%). Three clusters with markedly different features were identified. Cluster 1 was associated predominantly with elderly age, a high aortic valve gradient, and left ventricular (LV) hypertrophy; Cluster 2 consisted of preserved LV ejection fraction, larger aortic valve area, and high blood pressure; and Cluster 3 demonstrated tachycardia and low flow/low gradient AS. Adverse outcomes differed significantly among clusters during a median of 2.2 years of follow-up ( < 0.001). After adjustment for clinical and echocardiographic data in a Cox proportional hazards model, Cluster 3 (hazard ratio, 4.18; 95% confidence interval, 1.76-9.94; = 0.001) was associated with increased risk of adverse outcomes. In sequential Cox models, a model based on clinical data and echocardiographic variables ( = 18.4) was improved by Cluster 3 ( = 31.5; = 0.001) in the validation cohort. Unsupervised cluster analysis of patients after TAVR revealed three different groups for assessment of prognosis. This provides a new perspective in the categorization of patients after TAVR that considers comorbidities and extravalvular cardiac dysfunction. (徳島大学機関リポジトリ) ● Metadata: 118909 (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjopen/oead136 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38188937 ● Search Scopus @ Elsevier (PMID): 38188937 ● Search Scopus @ Elsevier (DOI): 10.1093/ehjopen/oead136 (徳島大学機関リポジトリ: 118909, DOI: 10.1093/ehjopen/oead136, PubMed: 38188937)
5.	TOMONORI Takahashi, H Iwano, K Shibayama, T Kitai, H Tanaka, Hirotsugu Yamada, Masataka Sata and Kenya Kusunose : The Clinical Utility of Noninvasive Forrester Classification in Acute Heart Failure from PREDICT Study, The American Journal of Cardiology, Vol.207, 75-81, 2023. (要約) The Forrester classification plays a crucial role in comprehending the underlying pathophysiology of heart failure (HF) and is employed to categorize the severity and predict the outcomes of patients with acute HF. Our objective was to assess the predictive value of the Forrester classification, based on noninvasive hemodynamic measurements obtained through Doppler echocardiography at admission, in forecasting the short-term prognosis posthospitalization of patients with acute HF. Patients were recruited for the Prospect trial to elucidate the utility of EchocarDIography-based Cardiac ouTput in acute heart failure (PREDICT) study, a multicenter, prospective study conducted in Japan. Participants were stratified into 4 profiles using cardiac index (CI) and early mitral filling velocity (E)/early-diastolic mitral annular velocity (e') ratio obtained from Doppler echocardiography upon admission (profile I: CI >2.2, E/e' ≤15, profile II: CI >2.2, E/e' >15, profile III: CI ≤2.2, E/e' ≤15, profile IV: CI ≤2.2, E/e' >15). The primary composite outcome of the study was all-cause mortality or worsening HF during the 14 days of hospitalization. Cox proportional hazards model analysis was employed to identify prognostic factors during the observation period. A total of 270 subjects, with a mean age of 74 ± 14 years and a male proportion of 60%, were enrolled in the study. During the 14-day period of hospitalization, 58 participants (22%) had a composite outcome. Patients with low CI (i.e., profiles III and IV) demonstrated an elevated risk of composite outcome after adjusting for confounding variables, as evidenced by the adjusted hazard ratios of 5.85 (95% confidence interval 1.17 to 29.09, p <0.01, vs profile III) and 6.50 (95% confidence interval 1.53 to 27.68, p <0.01, vs profile IV) in comparison with profile I, respectively. In conclusion, the Forrester classification, derived from noninvasive Doppler echocardiography at admission, may predict early deterioration in patients hospitalized with acute HF. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.amjcard.2023.08.119 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37734303 ● Search Scopus @ Elsevier (PMID): 37734303 ● Search Scopus @ Elsevier (DOI): 10.1016/j.amjcard.2023.08.119 (DOI: 10.1016/j.amjcard.2023.08.119, PubMed: 37734303)
6.	Sanae Morita, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Hirotsugu Yamada, Masataka Sata and Kenya Kusunose : Correlation between energy loss index and B-type natriuretic peptide: a vector flow mapping study, Journal of Echocardiography, Vol.22, No.1, 25-33, 2023. (要約) Vector Flow Mapping (VFM) and Energy Loss (EL) evaluation are emerging echocardiographic techniques that offer detailed insights into cardiac function. This study aimed to explore the relationship between EL parameters and B-type natriuretic peptide (BNP) levels, a well-established marker of heart failure severity. Our study prospectively enrolled 62 patients experiencing shortness of breath and suspected heart failure, who underwent echocardiography and had BNP levels measured between January 2018 and August 2020. Patients were stratified based on BNP levels, and their clinical and echocardiographic characteristics were evaluated. Univariate and multivariate regression analyses were performed to assess the correlation between BNP levels and various echocardiographic variables, including VFM parameters. Patients were stratified into two groups based on their BNP levels: BNP < 200 pg/ml (n = 53) and BNP 200 pg/ml (n = 9). Patients with BNP 200 pg/ml presented significantly different clinical and echocardiographic characteristics, such as older age, larger left ventricular mass and volume indices, higher pulmonary artery systolic pressure, higher E/e' ratio, and larger EL parameters. Multivariate regression analysis demonstrated the E/e' ratio and ELA (EL during Atrial contraction phase/A wave ratio as significant determinants of logBNP. Receiver operating characteristic curve analysis showed ELA/A > 36.0 J/m as a significant predictor of high BNP with 89% sensitivity and 85% specificity. ELA/A demonstrated an incremental diagnostic value over elevated left atrial pressure for predicting high BNP (C statistic = 0.98 vs 0.74, P = 0.006). This study provides novel insights into the potential utility of EL parameters as auxiliary indicators of cardiac load, thereby enhancing our understanding of heart failure. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-023-00623-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37707682 ● Summary page in Scopus @ Elsevier: 2-s2.0-85170841573 (DOI: 10.1007/s12574-023-00623-x, PubMed: 37707682, Elsevier: Scopus)
7.	Yuichiro Okushi, Yoshihito Saijyo, Hirotsugu Yamada, Hiroaki Toba, Robert Zheng, Hiromitsu Seno, TOMONORI Takahashi, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata and Kenya Kusunose : Effectiveness of surveillance by echocardiography for Cancer therapeutics-related cardiac dysfunction of patients with breast Cancer, Journal of Cardiology, Vol.82, No.6, 467-472, 2023. (要約) Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09-0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer. (徳島大学機関リポジトリ) ● Metadata: 118455 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jjcc.2023.07.002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37481235 ● Summary page in Scopus @ Elsevier: 2-s2.0-85166962366 (徳島大学機関リポジトリ: 118455, DOI: 10.1016/j.jjcc.2023.07.002, PubMed: 37481235, Elsevier: Scopus)
8.	TOMONORI Takahashi, Kenya Kusunose, S Hayashi, Robert Zheng, Natsumi Yamaguchi, Sae Morita, Yukina Hirata, Susumu Nishio, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Isoproterenol loading transesophageal echocardiography in atrial fibrillation, The International Journal of Cardiovascular Imaging, Vol.39, No.3, 511-518, 2023. (要約) In patients with sludge or severe spontaneous echo contrast (SEC) in the left atrial appendage (LAA), cases with isoproterenol loading transesophageal echocardiography (ISP-TEE) have been reported to identify the presence of thrombus in the LAA. This study aimed to assess the validity and hemodynamic changes of ISP-TEE in the LAA. We prospectively enrolled patients with atrial fibrillation (AF) who underwent ISP-TEE. The degree of sludge/SEC was categorized as being either absent (grade 0), mild SEC (grade 1), moderate SEC (grade 2), severe SEC or sludge (grade 3). The hemodynamic evaluation was performed by measuring LAA flow velocity, LAA tissue Doppler imaging (LAA-TDI) velocity, and pulmonary vein systolic forward flow velocity (PVS). In total, 35 patients (mean age 71 ± 7 years; 71% male) underwent ISP-TEE. Among 35 patients, 30 patients had grade 3 or 2 SEC, 5 patients had grade 1 SEC. After ISP loading, 23 patients (66% of all patients) showed improved sludge/SEC and one patient was diagnosed with thrombus in the LAA. There were 25 patients with grade 1 SEC, or no SEC (classified as Group1), 10 patients had residual sludge or grade 2 to 3 SEC (classified as Group2) after ISP administration. LAA flow, LAA-TDI, and PVS velocities were significantly higher in group 1 than in group 2 after ISP administration. There was no complication during the examination and after 24 h and 3 months. ISP infusion may be a potential tool to recognize LAA thrombus under the sludge/SEC during TEE in AF. (キーワード) Humans / Male / Middle Aged / Aged / Female / Atrial Fibrillation / Echocardiography, Transesophageal / Isoproterenol / Sewage / Atrial Appendage / Predictive Value of Tests / Thrombosis (徳島大学機関リポジトリ) ● Metadata: 118275 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10554-022-02749-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36357528 ● Search Scopus @ Elsevier (PMID): 36357528 ● Search Scopus @ Elsevier (DOI): 10.1007/s10554-022-02749-y (徳島大学機関リポジトリ: 118275, DOI: 10.1007/s10554-022-02749-y, PubMed: 36357528)

学術論文(紀要・その他):

1.	TOMONORI Takahashi, Tetsuzo Wakatsuki, Takayuki Ise and Masataka Sata : Spontaneous thrombosis of a giant aneurysm complicated with the coronary-to-pulmonary artery fistula: a case report, European Heart Journal. Case Reports, Vol.8, No.5, ytae227, 2024. (徳島大学機関リポジトリ) ● Metadata: 119332 (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjcr/ytae227 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38736999 ● Search Scopus @ Elsevier (PMID): 38736999 ● Search Scopus @ Elsevier (DOI): 10.1093/ehjcr/ytae227 (徳島大学機関リポジトリ: 119332, DOI: 10.1093/ehjcr/ytae227, PubMed: 38736999)

国際会議:

1.	TOMONORI Takahashi, Kenya Kusunose, S Kikuchi, N wahashi, Y Kinugasa, K Dohi, H Takase, K Inoue, T Okumura, S Kitada, Y Seo, Masataka Sata and N Ohte : Prognostic Utility of Non-invasive Left Atrial Stiffness Index in Patients with Heart Failure with Preserved Ejection Fraction: Insights from EASY-HFpEF study, Euro Echo 2024, Berlin, Dec. 2024.
2.	Natsumi Yamaguchi, TOMONORI Takahashi, Susumu Nishio, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : Elevated left atrial stiffness index is a poor prognostic factor in heart failure with preserved ejection fraction undergoing transcatheter aortic valve replacement, EUROECHO 2024, Dec. 2024.
3.	Tezuka Kazuki, Takeshi Soeki, Tomoko Takahashi, Tomomi Matsuura, Akihiro Tani, Ryo Bando, R Zheng, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Rie Ueno, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : Risk Factors For Intraoperative Instability In Sedated Patients Undergoing Pulmonary Vein Isolation Ablation, Sydney, Sep. 2024.
4.	Tomoko Takahashi, Takeshi Soeki, Tezuka Kazuki, TOMONORI Takahashi, Yoshihito Saijo, Tomoya Hara, Yutaka Kawabata, Muneyuki Kadota, Rie Ueno, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : NAFLD score predicts the onset of atrial fibrillation, APHRS 2024, Sydney, Sep. 2024.
5.	TOMONORI Takahashi, K Yamaji, S Kohsaka, H Ishii, Y Mori, Tetsuzo Wakatsuki, Koji Yamaguchi, D Nisioka, Kenya Kusunose, T Amano and Masataka Sata : Drug-Coated Balloon versus Drug-Eluting Stent for DeNovo Culprit Lesion in Acute Coronary Syndromes: A Report from Nationwide Registry in Japan, ESC 2024, London, Aug. 2024.
6.	Yoshihito Saijo, Hirotsugu Yamada, Robert Zheng, TOMONORI Takahashi, Yutaka Kawabata, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Differential echocardiographic profiles in immunoglobulin light chain and transthyretin amyloid cardiomyopathy: insights from speckle tracking analysis, ESC 2024, London, Aug. 2024.
7.	R Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, TOMONORI Takahashi, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Clinical outcome of DCB vs DES for de novo large coronary lesion in HBR patients, Euro PCR 2024, Paris, May 2024.
8.	Kohei Nagano, TOMONORI Takahashi, Tetsuzo Wakatsuki, Robert Zheng, Yoshihito Saijyo, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Long-Term Outcome of Stentless Coronary Intervention With Drug-Coated Balloon in Patients With High Bleeding Risk, AHA2023, Philadelphia, Nov. 2023.
9.	N Yamaguchi, Kenya Kusunose, Yukina Hirata, Susumu Nishio, TOMONORI Takahashi, Yoshihito Saijo, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Improved Pressure-Flow Relationship With Sacubitril/Valsartan: A 6-min Walk Stress Echocardiographic Study, AHA2023, Philadelphia, Nov. 2023.
10.	TOMONORI Takahashi, Tetsuzo Wakatsuki, Kenya Kusunose, Takayuki Ise and Masataka Sata : The aneurysm that vanished into thin air:Spontaneous thrombosis of a giant aneurysm complicated with the coronary to pulmonary artery fistula, ESC2023, Amsterdam, Aug. 2023.
11.	Ryou Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, TOMONORI Takahashi, Yoshihito Saijyo, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, S Yagi, Hirotsugu Yamada, T Soeki, M Akaike and Masataka Sata : Two-year outcomes of drug-coated balloon only strategy for de novo lesions in large coronary vessels, ESC2023, Amsterdam, Aug. 2023.
12.	Y Okushi, Kenya Kusunose, Hiromitsu Seno, TOMONORI Takahashi, Yoshihito Saijyo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : The Impact of Surveillance of Cancer Therapeutics-Related Cardiac Dysfunction by Periodic Echocardiography, ASE2022, Seattle, Jun. 2022.

国内講演発表:

1.	玉上大暉, 森西啓介, 平良竣也, 野田康裕, 林昌晃, 近田優介, 大藤純, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 : ローターブレーターのドライブシャフトシース破損の検証実験, 第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会 2024年9月7日(土)∼8日(日) 岡山, 2024年9月.
2.	野田康裕, 森西啓介, 平良竣也, 玉上大暉, 林昌晃, 近田優介, 大藤純, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 : Impella挿入患者の搬送に伴う人員と機器選定に苦慮した一例, 第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月.
3.	川端豊, 伊勢孝之, 坂東遼, ロバートゼング, 髙橋智紀, 上野理絵, 山口浩司, 若槻哲三, 佐田政隆 : 弓部大動脈に高度屈曲を有する外科的大動脈弁置換術後の人工弁機能不全に対して TF-TAVIを施行した1例, 第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月.
4.	坂東遼, 山口浩司, 髙橋智紀, 川端豊, 伊勢孝之, 若槻哲三, 佐田政隆 : 高出血リスク患者の急性冠症候群に対して薬剤塗布バルーンで治療を行い遠隔期に冠動脈瘤形成を認めた一例, 第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月.
5.	髙橋智紀, 若槻哲三, 髙橋智子, 坂東遼, ロバートゼング, 川端豊, 上野理絵, 伊勢孝之, 山口浩司, 佐田政隆 : 弁の石灰化と動脈蛇行の合併はTAVR術後の予後不良因子である:大動脈弁狭窄症患者のサブタイプ解析, 第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月.
6.	山口浩司, 若槻哲三, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 佐田政隆 : 高度石灰化病変に対して使用したDrug coated balloonが抜去困難・断裂した一例, 第30回日本心血管インターベンション治療学会(CVIT)中国四国地方会, 2024年9月.
7.	山口浩司, 若槻哲三, 坂東遼, 髙橋智紀, 川端豊, 伊勢孝之, 佐田政隆 : アブレーション後に生じた肺静脈厚土井狭窄病変に対する薬剤塗布バルーン有効2症例, 第32回日本心血管インターベンション治療学会; CVIT 2024, 2024年7月.
8.	S Kashima, TOMONORI Takahashi, K Nagano, R Bando, Yutaka Kawabata, Takayuki Ise, Koji Yamaguchi, Tetsuzo Wakatsuki and Masataka Sata : Association of High Lipoprotein(a) Levels with Adverse Outcomes in Patients with Stable Angina Undergoing Stentless PCI with Drug-coated balloon, 第32回日本心血管インターベンション治療学会; CVIT 2024, Jul. 2024.
9.	西條良仁, 山田博胤, Zheng Robert, 髙橋智紀, 坂東遼, 高橋智子, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 添木武, 若槻哲三, 笹聡一郎, 滝沢宏光, 佐田政隆 : Mechanical circulatory supportを要した重症がん治療関連心機能障害の1例, 第124回日本循環器学会中国・四国合同地方会, 2024年6月.
10.	八木一成, 八木秀介, 西條良仁, 高橋智子, Zheng Robert, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 山田博胤, 添木武, 若槻哲三, 佐田政隆, 秦広樹, 菅野幹雄 : 心室中隔欠損症・感染性心内膜炎を合併した大動脈縮窄証による二次性高血圧症の一例, 第124回日本循環器学会中国・四国合同地方会, 2024年6月.
11.	西條良仁, 山田博胤, Robert ZHENG, 髙橋智紀, 山口夏美, 平田有紀奈, 西尾進, 佐田政隆 : AL および TTR アミロイドーシスにおける心エコー所見の相違に関する検討, 第97回日本超音波医学会学術集会, 2024年5月.
12.	山口夏美, 西尾進, 髙橋智子, 野村侑香, 平田有紀奈, Robert ZHENG, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 : 左房内膜肉腫の 1 例, 第97回日本超音波医学会学術集会, 2024年5月.
13.	平田有紀奈, 野村侑香, 山口夏美, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆, 楠瀬賢也 : 心臓超音波検査における全自動解析システムによる精度と時間短縮の検証, 第35回日本心エコー図学会学術集会, 2024年4月.
14.	西條良仁, 楠瀬健也, 髙橋智紀, 山田博胤, 佐田政隆, 佐藤希美, Noor Albakaa, 石津智子, 瀬尾由広 : 経カテーテル的大動脈弁置換術における混合型」大動脈弁疾患の左室形状と予後への影響:多施設共同研究からの知見, 第35回日本心エコー図学会学術集会, 2024年4月.
15.	野村侑香, 平田有紀奈, 山口夏美, 森田沙瑛, 西尾進, Zheng Robert, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆, 楠瀬賢也 : 心臓超音波検査における全自動解析システムを用いた左室・左房ストレインの計測精度に関する検討, 第88回日本循環器学会学術集会, 2024年3月.
16.	Ryo Bando, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, TOMONORI Takahashi, Hayato Orino, Issei Yagi, TOMONORI Takahashi, Zheng Robert, Yoshihito Saijyo, Tomoya Hara, Muneyuki Kadota, Tomomi Matsuura, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Predictors of Late Lumen Enlargement after Drug Coated Balloon Angioplasty for de Novo Coronary Lesions, 第88回日本循環器学会学術集会 JCS2024, Mar. 2024.
17.	川端豊, 山口浩司, 若槻哲三, 髙橋智紀, 坂東遼, 西條良仁, 門田宗之, 松浦朋美, 伊勢孝之, 八木秀介, 添木武, 佐田政隆 : Microvasculature and Gene Expression in Pericoronary Adipose Tissue According to Coronary Plaque Progression Stage in Fresh Cadavers, 第88回日本循環器学会学術集会, 2024年3月.
18.	Yoshihito Saijyo, Hirotsugu Yamada, 長野絋平, 折野逸人, 八木一成, TAKAHASHI Tomoko, Zengu Robahto, BANDO Ryo, TOMONORI Takahashi, Tomoya Hara, Muneyuki Kadota, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Incremental Value of Relative Apical Sparing Index for Discrimination of Cardiac Amyloidosis Subtypes, 第88回日本循環器学会学術集会, Mar. 2024.
19.	平田有紀奈, 野村侑香, 山口夏美, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆, 楠瀬賢也 : 心臓超音波検査における全自動解析システムの可能性, 第88回日本循環器学会学術集会, 2024年3月.
20.	八木一成, 西條良仁, 長野絋平, 折野逸人, 吉田直史, 髙橋智子, Robert Zheng, 坂東遼, 髙橋智紀, 原知也, 門田宗之, 川端豊, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 佐田政隆 : ALおよびATTR心アミロイドーシス間のエコー図検査的特徴の相違に関する検討, 第123回日本循環器学会四国支部地方会, 2023年12月.
21.	髙橋智紀, 林修司, 山口夏美, 森田沙瑛, 平田有紀奈, 西尾進, Robert Zheng, 西條良仁, 山田博胤, 佐田政隆 : 3次元経食道超音波時代におけるランブル疣贅の頻度と形態評価, 第33回日本超音波産学会四国地方会学術集会, 2023年10月.
22.	平田有紀奈, 楠瀬賢也, 山口夏美, 森田沙瑛, 湯浅麻美, 松本力三, 西尾進, Robert Zheng, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 : 上腕動脈における血管柔軟性と性差・加齢との関係 ∼ViewWaveを用いた検討∼, 第71回日本心臓病学会学術集会，2023年9月8日(金)∼10日(日)，東京, 2023年9月.
23.	西尾進, 楠瀬賢也, 野村侑香, 山口夏美, 湯浅麻美, 松本力三, 平田有紀奈, Robahto Zengu, 髙橋智紀, 西條良仁, 山田博胤, 佐田政隆 : HFpEFに対する脈波増大指数の影響∼SphygmoCor-XCEL®を用いた検討∼, 第71回日本心臓病学会学術集会, 2023年9月.
24.	坂東遼, 山口浩司, 若槻哲三, 伊勢孝之, 川端豊, 髙橋智紀, Zheng Robert, 高橋智子, 吉田直史, 佐田政隆 : 薬剤塗布バルーン治療後に認めた遠隔期血管内腔拡大の長期観察, 第29回日本心血管インターヘンション治療学会(CVIT)中国四国地方会, 2023年9月.
25.	長野紘平, 髙橋智紀, 折野逸人, 大谷啓太, 根岸佑典, 八木一成, 吉田直史, ロバートゼング, 坂東遼, 川端豊, 伊勢孝之, 山口浩司, 若槻哲三, 佐田政隆 : 高血圧リスク患者に対する薬剤コーティングバルーンを用いたstentless PCI 治療の長期成績, 第29回日本心血管インターヘンション治療学会(CVIT)中国四国地方会, 2023年9月.
26.	Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, TOMONORI Takahashi, Takayuki Ise and Masataka Sata : Association of coronary plaque characteristics with vasa vasorum and local inflammation of epicardial adipose tissue in fresh cadavers, CVIT2023, Aug. 2023.
27.	Koji Yamaguchi, Tetsuzo Wakatsuki, Ryo Bando, TOMONORI Takahashi, Yutaka Kawabata, Takayuki Ise and Masataka Sata : Limitations of treatment for severely calcified lesions of renal arteries, CVIT2023, Aug. 2023.
28.	山口夏美, 西尾進, 平田有紀奈, 野村侑香, 森田沙瑛, 湯浅麻美, 松本力三, 髙橋智紀, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 : コロナウイルス感染後に左室心筋に高度の石灰化をきたした1例, 第48回日本超音波検査学会学術集会, 2023年6月.
29.	西尾進, 楠瀬賢也, 平田有紀奈, 山口夏美, Robert Zheng, 髙橋智紀, 瀬野弘光, 西條良仁, 山田博胤, 佐田政隆 : マルチモダリティによる心筋ストレイン評価, 第48回日本超音波検査学会学術集会, 2023年6月.
30.	山口夏美, 山田博胤, 門田宗之, 森田沙瑛, 平田有紀奈, 西尾進, 髙橋智紀, 西條良仁, 楠瀬賢也, 佐田政隆 : 心サルコイドーシスとの鑑別に苦慮した巨細胞性心筋炎の1 例, 第96回日本超音波医学会学術集会, 2023年5月.
31.	平田有紀奈, 山田博胤, 山口夏美, 森田沙瑛, 西尾進, 髙橋智紀, 西條良仁, 楠瀬賢也, 添木武, 佐田政隆 : マラソンと左房機能:スポーツ後の Cardiac fatigue とは, 96回日本超音波医学会学術集会, 2023年5月.
32.	髙橋智紀, 楠瀬賢也, 岩野弘幸, 柴山謙太郎, 北井豪, 田中秀和, 山田博胤, 佐田政隆 : 急性心不全における非侵襲的Forrester分類の臨床的有用性,, 第34回日本心エコー図学会学術集会, 2023年4月.
33.	髙橋智紀, 山田博胤, 和田靖明, 衣川尚知, 木村靖子, 野坂淳子, 井伊稚佳子, 米山里果, 内海郁恭, 楠瀬賢也, 佐田政隆 : 心不全ステージAの糖尿病患者における糖尿病性心筋症とその臨床背景および心エコー図指標に関する検討, 第37回日本心エコー図学会学術集会, 2023年4月.
34.	西條良仁, 楠瀬賢也, 山田博胤, Robert Zheng, 瀬野弘光, 髙橋智紀, 西尾進, 平田有紀奈, 森田沙瑛, 山口夏美, 佐田政隆 : 心房細動患者において心機能が左房憩室に与える影響の検討, 第37回日本心エコー図学会学術集会, 2023年4月.
35.	Zengu Robahto, Muneyuki Kadota, Keita Ohtani, Hayato Orino, Yusuke Negishi, Tomoko Takahashi, Ryo Bando, Hiromitsu Seno, TOMONORI Takahashi, Yoshihito Saijyo, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : A Case of Biopsy-Proven Giant Cell Myocarditis, 第37回日本心エコー図学会学術集会, Apr. 2023.
36.	西條良仁, 楠瀬賢也, 山田博胤, 瀬野弘光, 髙橋智紀, Robert Zheng, 西尾進, 平田有紀奈, 森田沙瑛, 山口夏美, 佐田政隆 : Mixed aortic valve diseaseにおいて中等度以上の大動脈弁膜症の併存が左室形態および予後に与える影響の検討, 第37回日本心エコー図学会学術集会, 2023年4月.
37.	山田博胤, 大櫛祐一郎, 楠瀬賢也, ゼングローバート, 髙橋智紀, 西條良仁, 西尾進, 平田有紀奈, 添木武, 佐田政隆 : 乳癌の薬物療法における心エコー図検査を用いた心毒性サーベイランスの有用性, 第37回日本心エコー図学会学術集会, 2023年4月.
38.	湯浅麻美, 西尾進, 山口夏美, 森田沙瑛, 松本力三, 平田有紀奈, 山尾雅美, Robert Zheng, 大櫛祐一郎, 瀬野弘光, 髙橋智紀, 西條良仁, 楠瀬賢也, 山田博胤, 佐田政隆 : ヘルスクロノスを用いた冠動脈狭窄検出の試み, 第8回日本血管不全学会学術集会, 2023年4月.
39.	西尾進, 楠瀬賢也, 平田有紀奈, 山口夏美, Robert Zheng, 髙橋智紀, 瀬野弘光, 西條良仁, 山田博胤, 佐田政隆 : 心エコー図検査における2Dストレイン計測の現状と課題, 第87回日本循環器学会学術集会, 2023年3月.
40.	Ryo Bando, Tetsuzo Wakatsuki, Koji Yamaguchi, Yutaka Kawabata, Ryota Miyamoto, Zengu Robahto, TOMONORI Takahashi, Yoshihito Saijyo, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Masashi Akaike and Masataka Sata : Two-year Outcomes of Drug-coated Balloon-only Strategy for De Novo Lesions in Large Coronary Vessels, 第87回日本循環器学会学術集会, Mar. 2023.
41.	Yoshihito Saijyo, Yuichiro Okushi, Kenya Kusunose, Hirotsugu Yamada, Zengu Robahto, TOMONORI Takahashi, Hiromitsu Seno, Susumu Nishio, Rie Ueno, Muneyuki Kadota, Tomoya Hara, Yutaka Kawabata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Utility of Periodic Echocardiographic Surveillance for Early Detection of Cardiac Dysfunction from Chemotherapy in Breast Cancer Patients, 第87回日本循環器学会学術集会, Mar. 2023.
42.	Takayuki Ise, Shusuke Yagi, Rie Ueno, Muneyuki Kadota, Keita Ohtani, Yusuke Negishi, Ryota Miyamoto, BANDO Ryo, Zengu Robahto, Hiromitsu Seno, TOMONORI Takahashi, Yutaka Kawabata, Yoshihito Saijyo, Tomomi Matsuura, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Novel Home-based Cardiac Telerehabilitation System Using a Wearable Device and a Web Application, 第87回日本循環器学会学術集会, Mar. 2023.
43.	Koji Yamaguchi, Tetsuzo Wakatsuki, TOMONORI Takahashi, Yutaka Kawabata, Takayuki Ise and Masataka Sata : The impact of polymer duration on local coagulative responses following drug-eluting stent implantation, 第30回日本心血管インターベンション治療学会学術集会, Jul. 2022.

その他・研究会:

1.	相原弘幸, 坂東遼, 松本遼太, 曽我部公子, Zheng Robert, 髙橋智紀, 西條良仁, 原知也, 門田宗之, 川端豊, 上野理絵, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 藤井志朗, 秦広樹, 佐田政隆 : 学生・研修医セッション1(冠動脈)血友病A患者における重症三枝病変に対する冠動脈バイパス術の一例, 第125回日本循環器学会四国地方会, 2024年12月.
2.	伊藤直司, 西條良仁, 手束一貴, 高橋智子, 谷彰浩, 坂東遼, ロバートゼング, 髙橋智紀, 門田宗之, 川端豊, 上野理絵, 原知也, 松浦朋美, 伊勢孝之, 山口浩司, 八木秀介, 山田博胤, 添木武, 若槻哲三, 松本遼太, 秦広樹, 佐田政隆 : ポスタ-セッション健康診断を契機に発見された巨大冠動脈瘤の一例, 第269回徳島医学会学術集会, 2024年7月.

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特任助教 : 髙橋智紀

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 髙橋 智紀

研究活動

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学術論文(審査論文):

学術論文(紀要・その他):

国際会議:

国内講演発表:

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

特任助教 : 髙橋智紀