Tokushima University / Educator and Researcher Directory --- Tawara, Hiroaki

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Tokushima University ⟩ University Hospital ⟩ 先端歯科医療開発研究プロジェクト ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Oral and Maxillofacial Surgery ⟩ Oral and Maxilofacial Surgery ⟩
Tokushima University ⟩ Research Clusters ⟩ Research Clusters ⟩ 2602008 健康から疾患への連続性を統合するデータ駆動・補助型医学研究と次世代DX人材育成の拠点形成 ⟩
Tokushima University ⟩ Faculty of Dentistry ⟩ Course in Dentistry ⟩ Clinical Dentistry for Oral Health and Surgery ⟩ Oral Surgery ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Kohei Naniwa, Hiroaki Tawara, 松崎史子, 金川裕子, Shinji Ono, NISHIDA Mari, 芳地浩彰, 大山博行, Mami Sato-Fukuba, Kohichi Kani, Makoto Fukui, Yukihiro Momota and Keiko Aota : 整形外科インプラント手術における周術期口腔機能管理の有効性の検討, Oral Care, 20, 1, 13-17, 2025. (Tokushima University Institutional Repository) ● Metadata: 2014032 (Tokushima University Institutional Repository: 2014032)
2.	Hiroaki Tawara, Takaaki Tsunematsu, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells., Biochemical and Biophysical Research Communications, 706, 149741, 2024. (Summary) The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production. (Keyword) Humans / Survivin / Centromere / Chromosomal Proteins, Non-Histone / Cell Cycle Proteins / Mitosis / Phosphorylation / Aurora Kinase B / Carcinoma, Squamous Cell / Lactates (Tokushima University Institutional Repository) ● Metadata: 2012071 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbrc.2024.149741 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38471204 ● Summary page in Scopus @ Elsevier: 2-s2.0-85187375126 (Tokushima University Institutional Repository: 2012071, DOI: 10.1016/j.bbrc.2024.149741, PubMed: 38471204, Elsevier: Scopus)

Proceeding of International Conference:

1.	Keiko Aota, Hiroaki Tawara, Mari Nishida, Shinji Ono, Hiroaki Hochi, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Daisuke Hinode and Fumihiko Tsushima : Effect of Perioperative Oral Management on Postoperative Pneumonia: A 16-Year Longitudinal and Department-Specific Analysis, The 6th Annual Meeting of the International Society of Oral Care, Matsumoto, May 2026.

Proceeding of Domestic Conference:

1.	Mami Sato-Fukuba, Ruka Nagao, 松澤鎮史, Risa Morioka, Hiroaki Tawara and Takaaki Tsunematsu : Molecular pathological analysis of salivary gland tumors with organoid models, 2026年若手支援技術講習会, Sep. 2026.
2.	Mami Sato-Fukuba, Ruka Nagao, Kohichi Kani, 松澤鎮史, Risa Morioka, Hiroaki Tawara and Takaaki Tsunematsu : 下顎骨病変, 日本病理学会中国四国支部学術集会(第150回スライドカンファレンス), Jul. 2026.
3.	Keiko Aota, Kohei Naniwa, Hiroaki Tawara, Mari Nishida, Shinji Ono, Hiroaki Hochi, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Daisuke Hinode and Fumihiko Tsushima : 周術期等口腔機能管理の導入拡充が全身麻酔術後肺炎に及ぼす影響:経年変化と診療科別比較による検討, 第23回日本口腔ケア学会総会学術大会, May 2026.
4.	Hiroaki Hochi, Keiko Aota, Mari Nishida, 大山博行, Hiroaki Tawara, Mami Sato-Fukuba, Kohei Naniwa, Kohichi Kani, Yukihiro Momota and Fumihiko Tsushima : 口腔症状を契機に診断に至った多発性内分泌腫瘍症2B型(MEN2B)の1例, 第70回日本口腔外科学会総会・学術大会, Nov. 2025.
5.	高岡由実, Kohei Naniwa, Mami Sato-Fukuba, Mari Nishida, 大山博行, Hiroaki Hochi, Hiroaki Tawara, Kohichi Kani, Yukihiro Momota and Keiko Aota : 唾液腺実質障害を伴わない口腔乾燥症の臨床的特徴と関連因子の検討, 第72回日本口腔科学会中国四国部会, Oct. 2025.
6.	Kohei Naniwa, 芳地浩彰, 大山博行, 西田真理, Hiroaki Tawara, Mami Sato-Fukuba, Kohichi Kani, Yukihiro Momota and Keiko Aota : 下顎歯肉に転移した肺腺癌の1例, 第53回日本口腔外科学会中四国支部学術集会, Jun. 2025.
7.	Hiroaki Tawara, Kohei Naniwa, Hiroko Kanagawa, 松崎史子, 富永賢, Makoto Fukui, Susumu Abe, Naoya Kitamura and Keiko Aota : 全身麻酔時の口腔内偶発症予防におけるマウスプロテクタの有効性に関する観察研究, 第22回口腔ケア学会, Apr. 2025.
8.	Takaaki Tsunematsu, Hiroaki Tawara, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : HPV陽性癌における新規ユビキチン化酵素複合体の機能解析, 第114回日本病理学会総会, Apr. 2025.
9.	Hiroaki Tawara, Takaaki Tsunematsu, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : 頭頚部扁平上皮癌の分化を決定づける転写因子ネットワークの解明, 第114回日本病理学会総会, Apr. 2025.
10.	Mami Sato-Fukuba, Kohei Naniwa, Hiroaki Tawara, Kohichi Kani, Yukihiro Momota, Takaaki Tsunematsu and Keiko Aota : シェーグレン症候群の唾液腺組織における脂肪浸潤の意義の探索, ダイバーシティ推進研究交流発表会2024, Mar. 2025.
11.	Hiroaki Tawara, Takaaki Tsunematsu, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : 頭頸部扁平上皮癌の分化を決定づける転写因子ネットワークの解明, 第47回日本分子生物学学会年会, Nov. 2024.
12.	Hiroaki Tawara, Takaaki Tsunematsu, Shigefumi Matsuzawa, Ruka Nagao, Kohei Naniwa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : 頭頸部扁平上皮癌の分化を決定づける転写ネットワークの解明, 第60回日本口腔組織培養学会総会・学術大会, Nov. 2024.
13.	Takaaki Tsunematsu, Naoya Kitamura, Hiroaki Tawara, Aya Ushio and Naozumi Ishimaru : HPV 陽性癌における新規脱ユビキチン化酵素複合体の機能解析, 第60回日本口腔口腔組織培養学会・学術集会, Nov. 2024.
14.	Hiroaki Tawara, Takaaki Tsunematsu, Ruka Nagao, Shigefumi Matsuzawa, Mami Sato-Fukuba, Kunihiro Otsuka and Keiko Aota : 転写因子TCF12による扁平上皮癌の分化制御機構の解明, 2024年度徳島大学先端酵素学研究所シンポジウム, Aug. 2024.
15.	Mami Sato-Fukuba, Hiroaki Tawara, Takaaki Tsunematsu and Keiko Aota : Association of salivary gland adipocytes and age-related inflammation, 徳島大学先端酵素学研究所シンポジウム, Aug. 2024.
16.	芳地浩彰, Kohichi Kani, 西田真理, 大山博行, Hiroaki Tawara, Mami Sato-Fukuba, Kohei Naniwa, Yukihiro Momota and Keiko Aota : 含歯性嚢胞の術後出血により判明した後天性凝固因子ⅩⅢ因子欠乏症の1例, 第53回日本口腔外科学会中国四国支部学術集会, Jun. 2024.
17.	Shigefumi Matsuzawa, Aya Ushio, Ruka Nagao, Kunihiro Otsuka, Hiroaki Tawara, Takaaki Tsunematsu and Naozumi Ishimaru : The relationship between autophagy in the neonatal thymus and Sjogren syndrome, 第113回日本病理学会総会, Mar. 2024.
18.	Hiroaki Tawara, Takaaki Tsunematsu, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : Borealin-Survivin複合体は頭頸部扁平上皮癌の分化を直接的に制御する, 第113回日本病理学会総会, Mar. 2024.
19.	Hiroaki Tawara, Takaaki Tsunematsu, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : 口腔扁平上皮癌におけるSurvivinの核内蓄積がもたらす新たな機能, 第59回日本口腔組織培養学会総会・学術大会, Nov. 2023.

Et cetera, Workshop:

1.	Kohei Naniwa, Hiroaki Tawara, 高岡由実, Mari Nishida, 金川裕子, Hiroaki Hochi, 大山博行, Mami Sato-Fukuba, Kohichi Kani, Yukihiro Momota, Makoto Fukui, Keizo Wada, Koichi Sairyo and Keiko Aota : 整形外科インプラント手術における周術期等口腔機能管理の有効性の検討, 第270回徳島医学会学術集会, Jul. 2025.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

頭頚部扁平上皮癌における新規Borealin-Survivin複合体による自然免疫抑制機構の解明 (Project/Area Number: 25K20247 )
Search by Researcher Number (41000061)