Tokushima University / Educator and Researcher Directory --- Tawara, Hiroaki

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Tokushima University ⟩ University Hospital ⟩ Central Clinical Facilities ⟩ Oral Health Management Center ⟩

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Academic Paper (Judged Full Paper):

1.	Hiroaki Tawara, Takaaki Tsunematsu, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells., Biochemical and Biophysical Research Communications, Vol.706, 149741, 2024. (Summary) The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production. (Keyword) Humans / Survivin / Centromere / Chromosomal Proteins, Non-Histone / Cell Cycle Proteins / Mitosis / Phosphorylation / Aurora Kinase B / Carcinoma, Squamous Cell / Lactates (Tokushima University Institutional Repository) ● Metadata: 119377 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbrc.2024.149741 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38471204 ● Search Scopus @ Elsevier (PMID): 38471204 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2024.149741 (Tokushima University Institutional Repository: 119377, DOI: 10.1016/j.bbrc.2024.149741, PubMed: 38471204)

Proceeding of Domestic Conference:

1.	Mami Sato-Fukuba, Hiroaki Tawara, Takaaki Tsunematsu and Keiko Aota : Association of salivary gland adipocytes and age-related inflammation, 徳島大学先端酵素学研究所シンポジウム, Aug. 2024.
2.	Hiroaki Tawara, Takaaki Tsunematsu, RUKA Nagao, MATSUZAWA Shigefumi, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : Borealin-Survivin複合体は頭頸部扁平上皮癌の分化を直接的に制御する, 第113回日本病理学会総会, Mar. 2024.
3.	Hiroaki Tawara, Takaaki Tsunematsu, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : 口腔扁平上皮癌におけるSurvivinの核内蓄積がもたらす新たな機能, 第59回日本口腔組織培養学会総会・学術大会, Nov. 2023.