徳島大学 / 教育研究者総覧 --- 俵宏彰

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徳島大学 ⟩ 病院 ⟩ 中央診療施設等 ⟩ 口腔管理センター ⟩

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著書・論文

学術論文(審査論文):

1.	Hiroaki Tawara, Takaaki Tsunematsu, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio and Naozumi Ishimaru : The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells., Biochemical and Biophysical Research Communications, Vol.706, 149741, 2024. (要約) The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production. (キーワード) Humans / Survivin / Centromere / Chromosomal Proteins, Non-Histone / Cell Cycle Proteins / Mitosis / Phosphorylation / Aurora Kinase B / Carcinoma, Squamous Cell / Lactates (徳島大学機関リポジトリ) ● Metadata: 2012071 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbrc.2024.149741 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38471204 ● Search Scopus @ Elsevier (PMID): 38471204 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2024.149741 (徳島大学機関リポジトリ: 2012071, DOI: 10.1016/j.bbrc.2024.149741, PubMed: 38471204)

国内講演発表:

1.	福場真美, 浪花耕平, 俵宏彰, 可児耕一, 桃田幸弘, 常松貴明, 青田桂子 : シェーグレン症候群の唾液腺組織における脂肪浸潤の意義の探索, ダイバーシティ推進研究交流発表会2024, 2025年3月.
2.	常松貴明, 北村直也, 俵宏彰, 牛尾綾, 石丸直澄 : HPV 陽性癌における新規脱ユビキチン化酵素複合体の機能解析, 第60回日本口腔口腔組織培養学会・学術集会, 2024年11月.
3.	福場真美, 俵宏彰, 常松貴明, 青田桂子 : Association of salivary gland adipocytes and age-related inflammation, 徳島大学先端酵素学研究所シンポジウム, 2024年8月.
4.	俵宏彰, 常松貴明, 永尾瑠佳, 松澤鎮史, 大塚邦紘, 牛尾綾, 石丸直澄 : Borealin-Survivin複合体は頭頸部扁平上皮癌の分化を直接的に制御する, 第113回日本病理学会総会, 2024年3月.
5.	俵宏彰, 常松貴明, 大塚邦紘, 牛尾綾, 石丸直澄 : 口腔扁平上皮癌におけるSurvivinの核内蓄積がもたらす新たな機能, 第59回日本口腔組織培養学会総会・学術大会, 2023年11月.