Tokushima University / Educator and Researcher Directory --- Matsuda, Hiroya

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Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Neurosurgery, Psychiatry and Anesthesiology ⟩ Psychiatry ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Neurosurgery, Psychiatry and Anesthesiology ⟩ Psychosomatic Medicine ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Yukiko Tomioka, Masahito Nakataki, Hidehiro Umehara, Tomohiro Yoshida, Hiroya Matsuda, Yui Matsumoto, Mariko Aoki, Yuri Yoshida, Yuichiroh Kamiyama, Tomohiko Nakayama, Naoki Yamada and Shusuke Numata : DNMT gene expression in peripheral leukocytes in schizophrenia and correlations with one-carbon metabolites: folate, total homocysteine, and vitamin B6., Frontiers in Psychiatry, 16, 2026. (Summary) Previous studies have identified alterations in one-carbon metabolism (OCM), including DNA methylation abnormalities, in individuals with schizophrenia. However, the precise etiology of this disorder remains unclear. In the present study, we examined variations in the expression of DNMT1 and DNMT3a-genes implicated in DNA methylation-using peripheral blood leukocytes from Japanese patients with chronic schizophrenia and healthy controls. Additionally, using our previously acquired data, we explored the association between OCM-related factors and DNMT expression levels.Expression levels of DNMT1 and DNMT3a in 215 patients with chronic schizophrenia and 210 healthy controls were quantified using real-time PCR. The Mann-Whitney U test was used to compare the differences between two independent groups. Furthermore, Spearman's correlation analysis was conducted to investigate the relationships between DNMT genes` expression levels and OCM-related metabolites (blood folate, vitamin B6, and total homocysteine).The expression levels of DNMT1 and DNMT3a in peripheral leukocytes were significantly elevated in patients with chronic schizophrenia compared with controls (p = 1.4 × 10-6 and 2.9 × 10-3, respectively). DNMT1 mRNA expression levels exhibited a weak negative correlation with folate exclusively in the aggregated cohort (N = 425) (ρ = -0.16, adjusted q = 5.0 × 10-3), and DNMT3a mRNA expression levels showed a weak negative correlation with vitamin B6 alone in the combined group (ρ = -0.12, adjusted q = 0.03).These findings suggest a potential correlation between nutritional status and elevated expression of DNMT1 and DNMT3a in schizophrenia. Our findings contribute to the understanding of the epigenetic mechanisms associated with schizophrenia and highlight the need for further investigation of the relationships among gene expression, nutritional status, and psychiatric manifestations. (Link to Publication Site) ● Publication site (DOI): 10.3389/fpsyt.2025.1715372 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41635517 ● Search Scopus @ Elsevier (PMID): 41635517 ● Search Scopus @ Elsevier (DOI): 10.3389/fpsyt.2025.1715372 (DOI: 10.3389/fpsyt.2025.1715372, PubMed: 41635517)
2.	Tomohiko Nakayama, Hidehiro Umehara, Kazuaki Mawatari, Yukiko Tomioka, Tomohiro Yoshida, Hiroya Matsuda, Yui Matsumoto, Masuda Rumiko, Kamishikiryo Toshiharu, Fuchikami Manabu, Masahito Nakataki, Akira Takahashi, Atsushi Tajima, Okada Go and Shusuke Numata : Alterations of Blood Plasma Metabolites, Including Kynurenine and Tryptophan, in Bipolar Disorder., Neuropsychiatric Disease and Treatment, 21, 1067-1073, 2025. (Link to Publication Site) ● Publication site (DOI): 10.2147/NDT.S508021 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-105006852907 (DOI: 10.2147/NDT.S508021, Elsevier: Scopus)

Proceeding of International Conference:

1.	Hidehiro Umehara, Kazuyuki Matsumoto, Tomohiko Nakayama, Hiroya Matsuda, Masahito Nakataki, Takaki Fukumori, Munenaga Koda, Kikuchi Keita, XIN KANG, Minoru Yoshida and Shusuke Numata : Deep Learning-Derived Multimodal Emotional Discordance During Anger Narratives and Its Association With Depression and Suicidal Ideation in Adolescents and Young Adults: The Moderating Role of Autistic Traits, 27th World Congress of IACAPAP 2026, Jul. 2026.

Proceeding of Domestic Conference:

1.	上山佑一郎, Hiroya Matsuda, Tomohiko Nakayama, Masahito Nakataki and Shusuke Numata : 修正型電気けいれん療法中に遷延する高振幅徐波を認めた2症例の検討, 【第65回中国・四国精神神経学会(2025.11.27-28 山口)】, Nov. 2025.
2.	Hiroya Matsuda, Masahito Nakataki, Junichi Iga, 長谷川尚美, 大井一高, 牧之段学, Yukiko Tomioka, 吉野祐太, 松本純弥, 中込和幸, 橋本亮太, Shu-ichi Ueno and Shusuke Numata : 精神疾患横断的血漿トリプトファンとキヌレニン濃度の検討, BPCNPNP2025合同年会, Nov. 2025.
3.	Tomohiro Inui, 一宮由貴, 三木幸代, 岡本恵, Hiroya Matsuda and Shusuke Numata : メサドンをadd-on法で導入し良好な疼痛コントロールを得た難治性がん疼痛の2例, 第30回日本緩和医療学会学術大会, Jul. 2025.
4.	吉田慧司, Hiroya Matsuda, Naoki Yamada, Masahito Nakataki and Shusuke Numata : 強迫性障害を合併したドゥ・ラ・トゥレット症候群の一例, 第64回中国・四国精神神経学会, Nov. 2024.
5.	Hidehiro Umehara, Tomoya Takeda, Tarishi Masuda, Hiroya Matsuda and Naoki Yamada : 猜疑心・敵意バイアスをターゲットとした青年期集団認知療法による内因性オキシトシンの変化., 第65回日本児童青年精神医学会, Oct. 2024.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Search by Researcher Number (01013127)